locus-tag	class	description
IG197_RS00015	COG1862	Preprotein translocase
IG197_RS00045	COG0519	Catalyzes the synthesis of GMP from XMP
IG197_RS00050	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IG197_RS00095	COG0544	peptidyl-prolyl cis-trans isomerase activity
IG197_RS00100	COG2003	Belongs to the UPF0758 family
IG197_RS00105	COG0024	Methionine aminopeptidase
IG197_RS00115	COG2824	Alkylphosphonate utilization operon protein PhnA
IG197_RS00125	COG1609	Transcriptional regulator
IG197_RS00135	COG1175	transmembrane transport
IG197_RS00140	COG0395	ABC-type sugar transport system, permease component
IG197_RS00155	COG3842	ATPase activity
IG197_RS00175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG197_RS00180	COG1116	anion transmembrane transporter activity
IG197_RS00185	COG4149	molybdate abc transporter
IG197_RS00195	COG2197	response regulator
IG197_RS00220	COG3243	poly(R)-hydroxyalkanoic acid synthase
IG197_RS00230	COG0436	Aminotransferase
IG197_RS00240	COG1494	fructose-1,6-bisphosphatase
IG197_RS00245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IG197_RS00250	COG1752	Esterase of the alpha-beta hydrolase superfamily
IG197_RS00255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IG197_RS00260	COG0302	gtp cyclohydrolase
IG197_RS00270	COG0583	DNA-binding transcription factor activity
IG197_RS00275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IG197_RS00285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IG197_RS00300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG197_RS00305	COG2301	Belongs to the HpcH HpaI aldolase family
IG197_RS00320	COG0187	DNA topoisomerase II activity
IG197_RS00335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG197_RS00335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IG197_RS00340	COG0509	glycine decarboxylation via glycine cleavage system
IG197_RS00345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS00355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG197_RS00370	COG1671	Belongs to the UPF0178 family
IG197_RS00380	COG2153	protein acetylation
IG197_RS00385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IG197_RS00395	COG4941	Belongs to the sigma-70 factor family
IG197_RS00400	COG3795	YCII-related domain
IG197_RS00415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IG197_RS00430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG197_RS00430	COG0475	glutathione-regulated potassium exporter activity
IG197_RS00445	COG3768	UPF0283 membrane protein
IG197_RS00450	COG3106	COG3106 Predicted ATPase
IG197_RS00485	COG0513	Belongs to the DEAD box helicase family
IG197_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS00505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IG197_RS00510	COG2897	thiosulfate sulfurtransferase activity
IG197_RS00525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IG197_RS00540	COG0686	Belongs to the AlaDH PNT family
IG197_RS00545	COG1522	sequence-specific DNA binding
IG197_RS00550	COG0737	Belongs to the 5'-nucleotidase family
IG197_RS00560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG197_RS00570	COG4957	zinc ion binding
IG197_RS00575	COG1530	ribonuclease E activity
IG197_RS00580	COG0860	N-Acetylmuramoyl-L-alanine amidase
IG197_RS00585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IG197_RS00610	COG2885	chlorophyll binding
IG197_RS00615	COG0513	Belongs to the DEAD box helicase family
IG197_RS00620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IG197_RS00630	COG3706	GGDEF domain
IG197_RS00650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IG197_RS00660	COG1414	Transcriptional regulator
IG197_RS00665	COG3960	tartronate-semialdehyde synthase activity
IG197_RS00670	COG3622	Belongs to the hyi family
IG197_RS00675	COG2084	Dehydrogenase
IG197_RS00690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG197_RS00705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG197_RS00730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IG197_RS00740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IG197_RS00745	COG0081	regulation of translation
IG197_RS00750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IG197_RS00755	COG0222	ribosome binding
IG197_RS00760	COG0085	RNA polymerase activity
IG197_RS00765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IG197_RS00775	COG0531	amino acid
IG197_RS00785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IG197_RS00790	COG0049	tRNA binding
IG197_RS00795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG197_RS00800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IG197_RS00805	COG0051	transcription antitermination factor activity, RNA binding
IG197_RS00810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IG197_RS00815	COG0088	Forms part of the polypeptide exit tunnel
IG197_RS00820	COG0089	rRNA binding
IG197_RS00825	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IG197_RS00830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IG197_RS00835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IG197_RS00840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IG197_RS00845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IG197_RS00850	COG0255	Belongs to the universal ribosomal protein uL29 family
IG197_RS00855	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IG197_RS00860	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IG197_RS00865	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IG197_RS00870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IG197_RS00875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IG197_RS00880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IG197_RS00885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IG197_RS00890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IG197_RS00895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IG197_RS00900	COG1841	ribosomal large subunit assembly
IG197_RS00905	COG0200	Binds to the 23S rRNA
IG197_RS00915	COG0563	adenylate kinase activity
IG197_RS00920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IG197_RS00925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IG197_RS00930	COG0202	RNA polymerase activity
IG197_RS00935	COG0203	ribosomal protein L17
IG197_RS00945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IG197_RS00950	COG0640	Transcriptional regulator
IG197_RS00980	COG0321	lipoyl(octanoyl) transferase activity
IG197_RS00980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IG197_RS00985	COG0084	hydrolase, TatD family'
IG197_RS01000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IG197_RS01005	COG1686	Belongs to the peptidase S11 family
IG197_RS01040	COG3706	GGDEF domain
IG197_RS01050	COG0708	Exodeoxyribonuclease III
IG197_RS01065	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IG197_RS01080	COG0583	DNA-binding transcription factor activity
IG197_RS01085	COG0601	transmembrane transport
IG197_RS01090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS01095	COG0444	Belongs to the ABC transporter superfamily
IG197_RS01100	COG4608	Belongs to the ABC transporter superfamily
IG197_RS01105	COG4166	transmembrane transport
IG197_RS01265	COG0739	heme binding
IG197_RS01275	COG0861	Integral membrane protein TerC family
IG197_RS01280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG197_RS01285	COG2814	Major facilitator Superfamily
IG197_RS01320	COG1024	Enoyl-CoA hydratase
IG197_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS01340	COG1960	acyl-CoA dehydrogenase activity
IG197_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS01370	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS01390	COG0183	Belongs to the thiolase family
IG197_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS01405	COG1960	acyl-CoA dehydrogenase activity
IG197_RS01420	COG1024	Enoyl-CoA hydratase
IG197_RS01420	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG197_RS01425	COG0604	alcohol dehydrogenase
IG197_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS01435	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS01485	COG0657	acetylesterase activity
IG197_RS01495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG197_RS01500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG197_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS01525	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IG197_RS01530	COG0183	Belongs to the thiolase family
IG197_RS01535	COG1960	acyl-CoA dehydrogenase activity
IG197_RS01540	COG1960	acyl-CoA dehydrogenase activity
IG197_RS01545	COG1024	Enoyl-CoA hydratase
IG197_RS01550	COG0667	Aldo Keto reductase
IG197_RS01555	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IG197_RS01595	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS01605	COG3845	ABC transporter
IG197_RS01615	COG1183	phosphatidylcholine synthase activity
IG197_RS01620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG197_RS01625	COG0679	Auxin Efflux Carrier
IG197_RS01640	COG4166	transmembrane transport
IG197_RS01655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IG197_RS01660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IG197_RS01665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IG197_RS01675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IG197_RS01680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG197_RS01685	COG0785	Cytochrome C biogenesis protein
IG197_RS01715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IG197_RS01930	COG4974	Belongs to the 'phage' integrase family
IG197_RS01955	COG0861	Integral membrane protein TerC family
IG197_RS01980	COG2308	Evidence 4 Homologs of previously reported genes of
IG197_RS01995	COG0488	(ABC) transporter
IG197_RS02010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IG197_RS02015	COG0343	queuine tRNA-ribosyltransferase activity
IG197_RS02020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IG197_RS02040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IG197_RS02050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IG197_RS02055	COG2095	MarC family integral membrane protein
IG197_RS02070	COG0629	single-stranded DNA binding
IG197_RS02080	COG2188	Transcriptional regulator
IG197_RS02085	COG1940	carbohydrate kinase activity
IG197_RS02090	COG0395	ABC-type sugar transport system, permease component
IG197_RS02115	COG1794	racemase activity, acting on amino acids and derivatives
IG197_RS02120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IG197_RS02125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG197_RS02140	COG1309	transcriptional regulator
IG197_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS02150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IG197_RS02150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IG197_RS02155	COG0347	Belongs to the P(II) protein family
IG197_RS02160	COG0174	glutamine synthetase
IG197_RS02180	COG0346	lactoylglutathione lyase activity
IG197_RS02190	COG0174	glutamine synthetase
IG197_RS02200	COG0697	spore germination
IG197_RS02205	COG0546	phosphoglycolate phosphatase activity
IG197_RS02215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IG197_RS02220	COG3956	TIGRFAM MazG family protein
IG197_RS02225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IG197_RS02230	COG1923	regulation of RNA biosynthetic process
IG197_RS02235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IG197_RS02240	COG0569	domain protein
IG197_RS02245	COG2204	response regulator
IG197_RS02250	COG5000	phosphorelay sensor kinase activity
IG197_RS02255	COG2204	response regulator
IG197_RS02260	COG3852	Histidine kinase
IG197_RS02270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IG197_RS02270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IG197_RS02275	COG1546	Belongs to the CinA family
IG197_RS02275	COG1058	Belongs to the CinA family
IG197_RS02285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IG197_RS02295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG197_RS02300	COG1214	PFAM Peptidase M22, glycoprotease
IG197_RS02300	COG0456	acetyltransferase
IG197_RS02310	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS02315	COG0022	dehydrogenase e1 component
IG197_RS02315	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS02320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IG197_RS02325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IG197_RS02330	COG0148	phosphopyruvate hydratase activity
IG197_RS02350	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IG197_RS02365	COG0504	CTP synthase activity
IG197_RS02380	COG0149	triose-phosphate isomerase activity
IG197_RS02390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IG197_RS02395	COG0134	indole-3-glycerol-phosphate synthase activity
IG197_RS02400	COG0315	cyclic pyranopterin monophosphate synthase activity
IG197_RS02405	COG0303	'Molybdopterin
IG197_RS02410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IG197_RS02420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG197_RS02425	COG0372	Belongs to the citrate synthase family
IG197_RS02430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG197_RS02440	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG197_RS02445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG197_RS02450	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IG197_RS02455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG197_RS02460	COG0750	zinc metalloprotease
IG197_RS02470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IG197_RS02475	COG0233	cytoplasmic translational termination
IG197_RS02480	COG0528	UMP kinase activity
IG197_RS02485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IG197_RS02490	COG0052	Belongs to the universal ribosomal protein uS2 family
IG197_RS02525	COG0537	adenosine 5'-monophosphoramidase activity
IG197_RS02550	COG3706	GGDEF domain
IG197_RS02560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IG197_RS02570	COG1686	Belongs to the peptidase S11 family
IG197_RS02575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IG197_RS02590	COG1760	l-serine dehydratase
IG197_RS02605	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IG197_RS02610	COG0154	amidase activity
IG197_RS02615	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IG197_RS02630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IG197_RS02635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IG197_RS02645	COG1960	acyl-CoA dehydrogenase activity
IG197_RS02650	COG0540	Belongs to the ATCase OTCase family
IG197_RS02655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG197_RS02660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IG197_RS02665	COG0758	DNA mediated transformation
IG197_RS02670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IG197_RS02675	COG0557	exoribonuclease II activity
IG197_RS02695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IG197_RS02705	COG0784	Response regulator, receiver
IG197_RS02720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IG197_RS02725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IG197_RS02730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IG197_RS02740	COG0492	ferredoxin-NADP+ reductase activity
IG197_RS02745	COG0633	Ferredoxin
IG197_RS02760	COG3218	ABC-type transport auxiliary lipoprotein component
IG197_RS02760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IG197_RS02770	COG1127	ABC transporter
IG197_RS02780	COG4948	Mandelate Racemase Muconate Lactonizing
IG197_RS02795	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS02800	COG0280	phosphate acetyltransferase
IG197_RS02800	COG0281	malic enzyme
IG197_RS02810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG197_RS02815	COG5265	(ABC) transporter
IG197_RS02820	COG0640	Transcriptional regulator
IG197_RS02830	COG0740	serine-type endopeptidase activity
IG197_RS02870	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IG197_RS02875	COG3384	dioxygenase
IG197_RS02905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IG197_RS02910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IG197_RS02915	COG0047	phosphoribosylformylglycinamidine synthase activity
IG197_RS02930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG197_RS02935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IG197_RS02950	COG2226	methyltransferase
IG197_RS02960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IG197_RS02965	COG2814	Major facilitator Superfamily
IG197_RS02970	COG0037	tRNA processing
IG197_RS02975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IG197_RS02985	COG1733	regulation of RNA biosynthetic process
IG197_RS02990	COG0702	epimerase
IG197_RS03000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IG197_RS03015	COG0538	isocitrate dehydrogenase activity
IG197_RS03030	COG0346	lactoylglutathione lyase activity
IG197_RS03035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IG197_RS03040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IG197_RS03050	COG2313	pseudouridylate synthase activity
IG197_RS03065	COG0316	Belongs to the HesB IscA family
IG197_RS03070	COG2151	metal-sulfur cluster biosynthetic enzyme
IG197_RS03075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IG197_RS03080	COG0719	Fe-S assembly protein
IG197_RS03085	COG0396	ATPase activity
IG197_RS03095	COG0719	Fe-S assembly protein
IG197_RS03105	COG2945	thiolester hydrolase activity
IG197_RS03140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IG197_RS03150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IG197_RS03155	COG0739	heme binding
IG197_RS03185	COG0583	DNA-binding transcription factor activity
IG197_RS03190	COG0747	negative chemotaxis
IG197_RS03195	COG0601	transmembrane transport
IG197_RS03205	COG0444	Belongs to the ABC transporter superfamily
IG197_RS03210	COG4608	Belongs to the ABC transporter superfamily
IG197_RS03215	COG3608	succinylglutamate desuccinylase aspartoacylase
IG197_RS03230	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IG197_RS03250	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG197_RS03270	COG1917	Cupin 2, conserved barrel domain protein
IG197_RS03275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG197_RS03285	COG0583	DNA-binding transcription factor activity
IG197_RS03305	COG0583	DNA-binding transcription factor activity
IG197_RS03335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IG197_RS03345	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IG197_RS03350	COG0156	8-amino-7-oxononanoate synthase activity
IG197_RS03360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG197_RS03365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG197_RS03380	COG4608	Belongs to the ABC transporter superfamily
IG197_RS03385	COG0444	Belongs to the ABC transporter superfamily
IG197_RS03390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS03395	COG0601	transmembrane transport
IG197_RS03400	COG1396	sequence-specific DNA binding
IG197_RS03405	COG0747	negative chemotaxis
IG197_RS03420	COG0776	regulation of translation
IG197_RS03430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IG197_RS03435	COG0740	serine-type endopeptidase activity
IG197_RS03480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IG197_RS03485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IG197_RS03495	COG0584	glycerophosphoryl diester phosphodiesterase
IG197_RS03500	COG0010	Belongs to the arginase family
IG197_RS03515	COG1612	heme a metabolic process
IG197_RS03545	COG0297	glycogen (starch) synthase activity
IG197_RS03580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IG197_RS03595	COG0776	regulation of translation
IG197_RS03600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG197_RS03605	COG0416	fatty acid biosynthetic process
IG197_RS03620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG197_RS03625	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IG197_RS03640	COG1174	glycine betaine transport
IG197_RS03645	COG1125	glycine betaine transport
IG197_RS03650	COG1174	glycine betaine transport
IG197_RS03655	COG1732	Glycine betaine
IG197_RS03660	COG2814	Major facilitator Superfamily
IG197_RS03665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG197_RS03670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IG197_RS03680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IG197_RS03680	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IG197_RS03685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IG197_RS03690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG197_RS03700	COG2989	Protein conserved in bacteria
IG197_RS03720	COG0113	porphobilinogen synthase activity
IG197_RS03730	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IG197_RS03740	COG0628	permease
IG197_RS03745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IG197_RS03755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IG197_RS03770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IG197_RS03795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IG197_RS03835	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS03840	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG197_RS03845	COG3845	ABC transporter
IG197_RS03885	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS03890	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG197_RS03895	COG3845	ABC transporter
IG197_RS03905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS03915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IG197_RS03940	COG0730	response to heat
IG197_RS03955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG197_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS03970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IG197_RS03975	COG1349	DNA-binding transcription factor activity
IG197_RS03990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IG197_RS03995	COG0583	DNA-binding transcription factor activity
IG197_RS04005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS04015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG197_RS04020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IG197_RS04025	COG2188	Transcriptional regulator
IG197_RS04050	COG0583	DNA-binding transcription factor activity
IG197_RS04055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IG197_RS04075	COG1846	Transcriptional regulator
IG197_RS04075	COG1940	carbohydrate kinase activity
IG197_RS04080	COG1653	transport
IG197_RS04105	COG3842	ATPase activity
IG197_RS04110	COG2252	PERMEase
IG197_RS04125	COG3842	ATPase activity
IG197_RS04135	COG0395	ABC-type sugar transport system, permease component
IG197_RS04150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IG197_RS04160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG197_RS04165	COG1132	(ABC) transporter
IG197_RS04170	COG3459	Glycosyltransferase 36 associated
IG197_RS04185	COG3314	Sporulation integral membrane protein YlbJ
IG197_RS04190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IG197_RS04200	COG2986	histidine ammonia-lyase
IG197_RS04205	COG1228	amidohydrolase
IG197_RS04225	COG0251	oxidation-reduction process
IG197_RS04230	COG1121	(ABC) transporter
IG197_RS04235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IG197_RS04240	COG0803	Belongs to the bacterial solute-binding protein 9 family
IG197_RS04250	COG0523	cobalamin synthesis protein
IG197_RS04280	COG1234	tRNA 3'-trailer cleavage
IG197_RS04290	COG1063	alcohol dehydrogenase
IG197_RS04305	COG4948	Mandelate Racemase Muconate Lactonizing
IG197_RS04315	COG1960	acyl-CoA dehydrogenase activity
IG197_RS04325	COG1902	pentaerythritol trinitrate reductase activity
IG197_RS04325	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS04330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IG197_RS04345	COG5598	trimethylamine methyltransferase
IG197_RS04350	COG0583	DNA-binding transcription factor activity
IG197_RS04355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IG197_RS04375	COG1663	tetraacyldisaccharide 4'-kinase activity
IG197_RS04380	COG1519	Transferase
IG197_RS04395	COG0483	inositol monophosphate 1-phosphatase activity
IG197_RS04400	COG0312	modulator of DNA gyrase
IG197_RS04415	COG0612	Peptidase, M16
IG197_RS04420	COG0612	Peptidase, M16
IG197_RS04425	COG0742	ribosomal rna small subunit methyltransferase
IG197_RS04430	COG1187	pseudouridine synthase activity
IG197_RS04435	COG0590	tRNA wobble adenosine to inosine editing
IG197_RS04445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IG197_RS04460	COG0196	riboflavin kinase activity
IG197_RS04475	COG2814	Major facilitator Superfamily
IG197_RS04485	COG1846	Transcriptional regulator
IG197_RS04490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IG197_RS04490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IG197_RS04500	COG0459	protein refolding
IG197_RS04505	COG1349	DNA-binding transcription factor activity
IG197_RS04530	COG3237	CsbD-like
IG197_RS04545	COG0114	fumarate hydratase activity
IG197_RS04550	COG2259	Doxx family
IG197_RS04560	COG0248	Ppx GppA phosphatase
IG197_RS04565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IG197_RS04575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG197_RS04585	COG1126	abc transporter atp-binding protein
IG197_RS04590	COG0765	amino acid transport
IG197_RS04595	COG4597	amino acid ABC transporter
IG197_RS04600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS04655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IG197_RS04835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG197_RS04845	COG0747	negative chemotaxis
IG197_RS04850	COG0601	transmembrane transport
IG197_RS04855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS04860	COG0444	Belongs to the ABC transporter superfamily
IG197_RS04885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IG197_RS04895	COG5425	PFAM Usg family protein
IG197_RS04905	COG0071	Belongs to the small heat shock protein (HSP20) family
IG197_RS04910	COG0071	Belongs to the small heat shock protein (HSP20) family
IG197_RS04920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IG197_RS04930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IG197_RS04970	COG0375	protein maturation
IG197_RS04975	COG0010	Belongs to the arginase family
IG197_RS04990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS05035	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS05045	COG0702	epimerase
IG197_RS05055	COG2186	Transcriptional regulator
IG197_RS05070	COG2186	Transcriptional regulator
IG197_RS05075	COG1136	(ABC) transporter
IG197_RS05135	COG3265	gluconokinase activity
IG197_RS05140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG197_RS05150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG197_RS05155	COG2084	Dehydrogenase
IG197_RS05200	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IG197_RS05250	COG0444	Belongs to the ABC transporter superfamily
IG197_RS05255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG197_RS05270	COG0747	negative chemotaxis
IG197_RS05275	COG2186	Transcriptional regulator
IG197_RS05290	COG1473	amidohydrolase
IG197_RS05300	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
IG197_RS05310	COG3474	cytochrome
IG197_RS05440	COG0210	DNA helicase
IG197_RS05470	COG0640	Transcriptional regulator
IG197_RS05475	COG0798	PFAM Bile acid sodium symporter
IG197_RS05485	COG0431	NADPH-dependent FMN reductase
IG197_RS05510	COG0753	catalase activity
IG197_RS05550	COG1278	Cold shock
IG197_RS05560	COG3685	Protein conserved in bacteria
IG197_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS05620	COG2827	Endonuclease containing a URI domain
IG197_RS05660	COG2827	Endonuclease containing a URI domain
IG197_RS05665	COG2205	protein histidine kinase activity
IG197_RS05665	COG2198	Histidine kinase
IG197_RS05665	COG0784	Response regulator, receiver
IG197_RS05670	COG2197	response regulator
IG197_RS05690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS05745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IG197_RS05750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IG197_RS05760	COG0384	phenazine biosynthesis protein PhzF
IG197_RS05765	COG3436	PFAM IS66 Orf2 family protein
IG197_RS05840	COG0583	DNA-binding transcription factor activity
IG197_RS05845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS05850	COG0765	amino acid transport
IG197_RS05860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IG197_RS05870	COG0243	molybdopterin cofactor binding
IG197_RS05875	COG0488	(ABC) transporter
IG197_RS05880	COG2211	Major facilitator Superfamily
IG197_RS05900	COG0105	UTP biosynthetic process
IG197_RS05915	COG0314	molybdopterin synthase activity
IG197_RS05930	COG0322	excinuclease ABC activity
IG197_RS05985	COG0625	glutathione transferase activity
IG197_RS06000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IG197_RS06025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IG197_RS06050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IG197_RS06055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IG197_RS06060	COG0194	GDP metabolic process
IG197_RS06065	COG1561	YicC-like family, N-terminal region
IG197_RS06070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IG197_RS06075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IG197_RS06080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG197_RS06090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IG197_RS06095	COG1368	sulfuric ester hydrolase activity
IG197_RS06100	COG0360	Binds together with S18 to 16S ribosomal RNA
IG197_RS06110	COG0359	binds to the 23S rRNA
IG197_RS06115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IG197_RS06120	COG1742	UPF0060 membrane protein
IG197_RS06125	COG3468	outer membrane autotransporter barrel domain protein
IG197_RS06130	COG0305	Participates in initiation and elongation during chromosome replication
IG197_RS06145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IG197_RS06155	COG4221	oxidoreductase activity
IG197_RS06160	COG3273	potassium ion transport
IG197_RS06160	COG0471	metal ion transport
IG197_RS06190	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS06190	COG0204	Acyl-transferase
IG197_RS06200	COG0688	phosphatidylethanolamine metabolic process
IG197_RS06205	COG5265	(ABC) transporter
IG197_RS06215	COG1652	LysM domain
IG197_RS06230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG197_RS06260	COG2852	Protein conserved in bacteria
IG197_RS06265	COG0215	cysteine-tRNA ligase activity
IG197_RS06305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG197_RS06315	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IG197_RS06345	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS06355	COG0640	Transcriptional regulator
IG197_RS06390	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
IG197_RS06420	COG1381	Involved in DNA repair and RecF pathway recombination
IG197_RS06425	COG0477	Major facilitator Superfamily
IG197_RS06445	COG2814	Major facilitator Superfamily
IG197_RS06465	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS06495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG197_RS06510	COG1280	lysine exporter protein (LysE YggA)
IG197_RS06530	COG2814	Major facilitator Superfamily
IG197_RS06555	COG0300	oxidoreductase activity
IG197_RS06600	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS06610	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS06615	COG1177	transmembrane transport
IG197_RS06620	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS06625	COG3842	ATPase activity
IG197_RS06630	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS06645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IG197_RS06650	COG0571	ribonuclease III activity
IG197_RS06655	COG0681	Belongs to the peptidase S26 family
IG197_RS06660	COG0736	holo-[acyl-carrier-protein] synthase activity
IG197_RS06665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IG197_RS06675	COG1758	RNA polymerase activity
IG197_RS06695	COG2827	Endonuclease containing a URI domain
IG197_RS06700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IG197_RS06705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG197_RS06710	COG0741	lytic transglycosylase activity
IG197_RS06740	COG4974	Belongs to the 'phage' integrase family
IG197_RS06755	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IG197_RS06760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG197_RS06770	COG1960	acyl-CoA dehydrogenase activity
IG197_RS06790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG197_RS06795	COG4770	biotin carboxylase activity
IG197_RS06805	COG0450	alkyl hydroperoxide reductase
IG197_RS06825	COG0625	glutathione transferase activity
IG197_RS06835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IG197_RS06865	COG1573	uracil-dna glycosylase
IG197_RS06880	COG0438	transferase activity, transferring glycosyl groups
IG197_RS06895	COG0308	aminopeptidase N
IG197_RS06900	COG2205	protein histidine kinase activity
IG197_RS06900	COG2202	Pas domain
IG197_RS06905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG197_RS06915	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IG197_RS06920	COG2205	protein histidine kinase activity
IG197_RS06925	COG0745	RESPONSE REGULATOR receiver
IG197_RS06930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG197_RS06935	COG3088	subunit of a heme lyase
IG197_RS06940	COG1138	Cytochrome C-type biogenesis protein
IG197_RS06945	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IG197_RS06950	COG4235	cytochrome complex assembly
IG197_RS06980	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IG197_RS07015	COG2205	protein histidine kinase activity
IG197_RS07025	COG2166	iron-sulfur cluster assembly
IG197_RS07030	COG4957	zinc ion binding
IG197_RS07035	COG1320	monovalent cation:proton antiporter activity
IG197_RS07040	COG2212	antiporter activity
IG197_RS07045	COG1863	multisubunit Na H antiporter MnhE subunit
IG197_RS07050	COG0651	ATP synthesis coupled electron transport
IG197_RS07055	COG1006	Multisubunit Na H antiporter MnhC subunit
IG197_RS07060	COG2111	Na H antiporter
IG197_RS07065	COG2111	Na H antiporter
IG197_RS07065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IG197_RS07080	COG2010	Cytochrome c
IG197_RS07085	COG3909	cytochrome
IG197_RS07090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IG197_RS07095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IG197_RS07115	COG0433	COG0433 Predicted ATPase
IG197_RS07120	COG2336	PFAM SpoVT AbrB
IG197_RS07125	COG3654	unkown
IG197_RS07130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG197_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS07145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IG197_RS07150	COG1309	transcriptional regulator
IG197_RS07155	COG3119	arylsulfatase activity
IG197_RS07165	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IG197_RS07170	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS07180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG197_RS07205	COG4172	Belongs to the ABC transporter superfamily
IG197_RS07210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS07215	COG0601	transmembrane transport
IG197_RS07225	COG0366	Alpha amylase catalytic
IG197_RS07230	COG1523	belongs to the glycosyl hydrolase 13 family
IG197_RS07235	COG0033	Phosphoglucomutase
IG197_RS07240	COG0297	glycogen (starch) synthase activity
IG197_RS07245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IG197_RS07250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IG197_RS07255	COG0058	SHG alpha-glucan phosphorylase activity
IG197_RS07275	COG1940	carbohydrate kinase activity
IG197_RS07295	COG1218	3'(2'),5'-bisphosphate nucleotidase
IG197_RS07305	COG0175	sulfate reduction
IG197_RS07345	COG3685	Protein conserved in bacteria
IG197_RS07375	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS07390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG197_RS07390	COG0574	Belongs to the PEP-utilizing enzyme family
IG197_RS07405	COG0583	DNA-binding transcription factor activity
IG197_RS07410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IG197_RS07415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG197_RS07425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG197_RS07425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG197_RS07435	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS07450	COG0183	Belongs to the thiolase family
IG197_RS07460	COG0454	-acetyltransferase
IG197_RS07465	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IG197_RS07475	COG4172	Belongs to the ABC transporter superfamily
IG197_RS07480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS07490	COG0747	negative chemotaxis
IG197_RS07495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IG197_RS07500	COG2971	BadF BadG BcrA BcrD
IG197_RS07505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG197_RS07510	COG1737	Transcriptional regulator
IG197_RS07515	COG0243	molybdopterin cofactor binding
IG197_RS07525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG197_RS07535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG197_RS07540	COG3707	response regulator
IG197_RS07545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG197_RS07550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG197_RS07565	COG1196	nuclear chromosome segregation
IG197_RS07580	COG1194	a g-specific adenine glycosylase
IG197_RS07585	COG1011	Hydrolase
IG197_RS07590	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IG197_RS07595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG197_RS07615	COG0583	DNA-binding transcription factor activity
IG197_RS07620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG197_RS07635	COG0612	Peptidase, M16
IG197_RS07640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IG197_RS07650	COG1678	Uncharacterized ACR, COG1678
IG197_RS07660	COG0678	peroxiredoxin activity
IG197_RS07665	COG0328	RNA-DNA hybrid ribonuclease activity
IG197_RS07670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IG197_RS07675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IG197_RS07680	COG3346	SURF1 family
IG197_RS07700	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IG197_RS07710	COG0109	protoheme IX farnesyltransferase activity
IG197_RS07715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG197_RS07720	COG1565	acr, cog1565
IG197_RS07720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IG197_RS07730	COG0312	modulator of DNA gyrase
IG197_RS07735	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IG197_RS07740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IG197_RS07750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IG197_RS07755	COG1741	Belongs to the pirin family
IG197_RS07770	COG1733	regulation of RNA biosynthetic process
IG197_RS07775	COG1722	exodeoxyribonuclease VII activity
IG197_RS07780	COG0123	including yeast histone deacetylase and acetoin utilization protein
IG197_RS07785	COG1309	transcriptional regulator
IG197_RS07805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IG197_RS07805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IG197_RS07810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IG197_RS07820	COG0406	alpha-ribazole phosphatase activity
IG197_RS07825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IG197_RS07830	COG0484	heat shock protein binding
IG197_RS07840	COG0259	pyridoxamine-phosphate oxidase activity
IG197_RS07850	COG1024	Enoyl-CoA hydratase
IG197_RS07855	COG1960	acyl-CoA dehydrogenase activity
IG197_RS07870	COG0151	Belongs to the GarS family
IG197_RS07890	COG0009	L-threonylcarbamoyladenylate synthase
IG197_RS07905	COG0751	glycine-tRNA ligase activity
IG197_RS07915	COG0752	glycyl-tRNA synthetase alpha subunit
IG197_RS07925	COG0142	geranyltranstransferase activity
IG197_RS07950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IG197_RS07955	COG0521	Mo-molybdopterin cofactor biosynthetic process
IG197_RS07970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IG197_RS07980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IG197_RS07985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IG197_RS07990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG197_RS07995	COG0356	it plays a direct role in the translocation of protons across the membrane
IG197_RS08010	COG1160	GTP binding
IG197_RS08025	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IG197_RS08030	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IG197_RS08040	COG0583	DNA-binding transcription factor activity
IG197_RS08045	COG1393	Belongs to the ArsC family
IG197_RS08050	COG0251	oxidation-reduction process
IG197_RS08060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG197_RS08080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG197_RS08090	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS08105	COG0494	nUDIX hydrolase
IG197_RS08110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS08125	COG0657	acetylesterase activity
IG197_RS08135	COG0583	DNA-binding transcription factor activity
IG197_RS08140	COG0242	peptide deformylase activity
IG197_RS08160	COG4608	Belongs to the ABC transporter superfamily
IG197_RS08170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS08175	COG0601	transmembrane transport
IG197_RS08220	COG0840	transmembrane signaling receptor activity
IG197_RS08225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG197_RS08235	COG3386	PFAM SMP-30 Gluconolaconase
IG197_RS08240	COG0800	Aldolase
IG197_RS08245	COG3734	2-keto-3-deoxy-galactonokinase
IG197_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS08255	COG2017	converts alpha-aldose to the beta-anomer
IG197_RS08265	COG1129	ABC transporter
IG197_RS08275	COG2186	Transcriptional regulator
IG197_RS08280	COG4948	Mandelate Racemase Muconate Lactonizing
IG197_RS08300	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG197_RS08305	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS08310	COG3845	ABC transporter
IG197_RS08315	COG0583	DNA-binding transcription factor activity
IG197_RS08325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IG197_RS08330	COG0163	prenyltransferase activity
IG197_RS08350	COG0523	cobalamin synthesis protein
IG197_RS08355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG197_RS08370	COG2233	PERMEase
IG197_RS08375	COG0583	DNA-binding transcription factor activity
IG197_RS08390	COG0431	NADPH-dependent FMN reductase
IG197_RS08445	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IG197_RS08450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG197_RS08450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IG197_RS08455	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IG197_RS08460	COG0583	DNA-binding transcription factor activity
IG197_RS08465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IG197_RS08470	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IG197_RS08475	COG0124	histidyl-tRNA synthetase
IG197_RS08490	COG2818	Glycosylase
IG197_RS08495	COG1376	ErfK ybiS ycfS ynhG family protein
IG197_RS08500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IG197_RS08505	COG1388	LysM domain
IG197_RS08505	COG1376	ErfK ybiS ycfS ynhG family protein
IG197_RS08515	COG0247	lactate metabolic process
IG197_RS08530	COG2852	Protein conserved in bacteria
IG197_RS08540	COG0277	FAD linked oxidase domain protein
IG197_RS08550	COG2186	Transcriptional regulator
IG197_RS08555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IG197_RS08620	COG0583	DNA-binding transcription factor activity
IG197_RS08625	COG1570	exodeoxyribonuclease VII activity
IG197_RS08635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG197_RS08640	COG1178	ABC-type Fe3 transport system permease component
IG197_RS08645	COG1840	ABC-type Fe3 transport system, periplasmic component
IG197_RS08650	COG2205	protein histidine kinase activity
IG197_RS08655	COG5490	Phasin protein
IG197_RS08680	COG1177	transmembrane transport
IG197_RS08685	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS08690	COG3842	ATPase activity
IG197_RS08705	COG0431	NADPH-dependent FMN reductase
IG197_RS08710	COG2814	Major facilitator Superfamily
IG197_RS08720	COG3300	MHYT domain
IG197_RS08720	COG5001	Diguanylate cyclase
IG197_RS08730	COG2224	Isocitrate lyase
IG197_RS08750	COG0174	glutamine synthetase
IG197_RS08755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS08765	COG0642	Histidine kinase
IG197_RS08770	COG0745	RESPONSE REGULATOR receiver
IG197_RS08785	COG3794	PFAM blue (type 1) copper domain protein
IG197_RS08810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IG197_RS08815	COG0363	glucosamine-6-phosphate deaminase activity
IG197_RS08820	COG0129	dihydroxy-acid dehydratase activity
IG197_RS08830	COG0488	(ABC) transporter
IG197_RS08845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IG197_RS08900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IG197_RS08905	COG4149	molybdate abc transporter
IG197_RS08910	COG0725	ABC transporter, periplasmic molybdate-binding protein
IG197_RS08915	COG0730	response to heat
IG197_RS08920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IG197_RS08925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IG197_RS08935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG197_RS09040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IG197_RS09050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IG197_RS09055	COG5328	Belongs to the UPF0262 family
IG197_RS09065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IG197_RS09070	COG0424	maF-like protein
IG197_RS09075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IG197_RS09085	COG5001	Diguanylate cyclase
IG197_RS09085	COG3300	MHYT domain
IG197_RS09095	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS09100	COG2186	Transcriptional regulator
IG197_RS09130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IG197_RS09135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS09165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG197_RS09175	COG0251	oxidation-reduction process
IG197_RS09185	COG0765	amino acid transport
IG197_RS09190	COG0765	amino acid transport
IG197_RS09210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IG197_RS09215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG197_RS09220	COG1120	ATPase activity
IG197_RS09225	COG3585	molybdate ion transport
IG197_RS09240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS09245	COG4215	(ABC) transporter
IG197_RS09250	COG0765	amino acid transport
IG197_RS09255	COG3457	Alanine racemase
IG197_RS09260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS09270	COG0156	8-amino-7-oxononanoate synthase activity
IG197_RS09275	COG0436	Aminotransferase
IG197_RS09280	COG1970	mechanosensitive ion channel activity
IG197_RS09285	COG0784	Response regulator, receiver
IG197_RS09285	COG2205	protein histidine kinase activity
IG197_RS09285	COG2198	Histidine kinase
IG197_RS09305	COG0167	dihydroorotate dehydrogenase activity
IG197_RS09315	COG0123	including yeast histone deacetylase and acetoin utilization protein
IG197_RS09325	COG5001	Diguanylate cyclase
IG197_RS09335	COG0463	Glycosyl transferase, family 2
IG197_RS09350	COG0717	Belongs to the dCTP deaminase family
IG197_RS09360	COG2967	ApaG domain
IG197_RS09370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG197_RS09375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IG197_RS09385	COG0598	Magnesium transport protein CorA
IG197_RS09390	COG0704	Plays a role in the regulation of phosphate uptake
IG197_RS09400	COG0640	Transcriptional regulator
IG197_RS09405	COG5002	protein histidine kinase activity
IG197_RS09410	COG2326	polyphosphate kinase activity
IG197_RS09415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS09425	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IG197_RS09455	COG1024	Enoyl-CoA hydratase
IG197_RS09455	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG197_RS09460	COG0183	Belongs to the thiolase family
IG197_RS09465	COG1960	acyl-CoA dehydrogenase activity
IG197_RS09470	COG1960	acyl-CoA dehydrogenase activity
IG197_RS09480	COG0730	response to heat
IG197_RS09490	COG0789	Transcriptional regulator
IG197_RS09500	COG1201	RNA secondary structure unwinding
IG197_RS09520	COG1793	dna ligase
IG197_RS09630	COG3422	double-strand break repair
IG197_RS09645	COG0444	Belongs to the ABC transporter superfamily
IG197_RS09650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS09660	COG0747	negative chemotaxis
IG197_RS09665	COG4608	Belongs to the ABC transporter superfamily
IG197_RS09670	COG0444	Belongs to the ABC transporter superfamily
IG197_RS09675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS09680	COG0601	transmembrane transport
IG197_RS09685	COG0747	negative chemotaxis
IG197_RS09695	COG0546	phosphoglycolate phosphatase activity
IG197_RS09700	COG0024	Methionine aminopeptidase
IG197_RS09725	COG2226	methyltransferase
IG197_RS09730	COG0129	dihydroxy-acid dehydratase activity
IG197_RS09800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG197_RS09805	COG0166	Belongs to the GPI family
IG197_RS09820	COG0489	protein tyrosine kinase activity
IG197_RS09845	COG0583	DNA-binding transcription factor activity
IG197_RS09860	COG3383	formate dehydrogenase (NAD+) activity
IG197_RS09865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IG197_RS09875	COG2197	response regulator
IG197_RS09910	COG5002	protein histidine kinase activity
IG197_RS09915	COG1349	DNA-binding transcription factor activity
IG197_RS09925	COG4175	Glycine betaine
IG197_RS09925	COG0517	IMP dehydrogenase activity
IG197_RS09930	COG4176	ABC-type proline glycine betaine transport system permease component
IG197_RS09945	COG2340	Cysteine-rich secretory protein family
IG197_RS09950	COG0697	spore germination
IG197_RS09960	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS09965	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS09970	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG197_RS09975	COG3845	ABC transporter
IG197_RS09985	COG1132	(ABC) transporter
IG197_RS09990	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS09995	COG0288	reversible hydration of carbon dioxide
IG197_RS10035	COG2433	Pfam Transposase IS66
IG197_RS10040	COG3436	PFAM IS66 Orf2 family protein
IG197_RS10045	COG2963	transposase activity
IG197_RS10070	COG0069	glutamate synthase activity
IG197_RS10075	COG2218	PFAM glutamate synthase alpha subunit domain protein
IG197_RS10080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IG197_RS10090	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IG197_RS10090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS10105	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS10120	COG0583	DNA-binding transcription factor activity
IG197_RS10135	COG2948	multi-organism process
IG197_RS10145	COG3701	Conjugal transfer protein
IG197_RS10150	COG3846	protein secretion by the type IV secretion system
IG197_RS10165	COG3451	type IV secretory pathway VirB4
IG197_RS10180	COG4962	Type ii secretion system protein e
IG197_RS10205	COG0741	lytic transglycosylase activity
IG197_RS10235	COG1192	Involved in chromosome partitioning
IG197_RS10285	COG5489	Protein of unknown function (DUF736)
IG197_RS10335	COG2255	four-way junction helicase activity
IG197_RS10355	COG5002	protein histidine kinase activity
IG197_RS10360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IG197_RS10365	COG0594	ribonuclease P activity
IG197_RS10370	COG0706	membrane insertase activity
IG197_RS10380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IG197_RS10390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG197_RS10395	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IG197_RS10410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IG197_RS10425	COG3186	Phenylalanine-4-hydroxylase
IG197_RS10435	COG0477	Major facilitator Superfamily
IG197_RS10440	COG3706	GGDEF domain
IG197_RS10460	COG2171	N-acyltransferase activity
IG197_RS10470	COG3152	Membrane
IG197_RS10490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG197_RS10510	COG0101	tRNA pseudouridine synthase activity
IG197_RS10520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IG197_RS10525	COG0242	peptide deformylase activity
IG197_RS10560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG197_RS10570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IG197_RS10575	COG3409	Peptidoglycan-binding domain 1 protein
IG197_RS10575	COG3773	Cell wall hydrolase
IG197_RS10585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IG197_RS10590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IG197_RS10610	COG2816	NAD+ diphosphatase activity
IG197_RS10615	COG2226	methyltransferase
IG197_RS10620	COG0077	Prephenate dehydratase
IG197_RS10620	COG1605	Chorismate mutase
IG197_RS10625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IG197_RS10630	COG3474	cytochrome
IG197_RS10635	COG4166	transmembrane transport
IG197_RS10640	COG4166	transmembrane transport
IG197_RS10645	COG4174	ABC transporter (Permease)
IG197_RS10650	COG4239	(ABC) transporter, permease
IG197_RS10655	COG4172	Belongs to the ABC transporter superfamily
IG197_RS10665	COG0791	NLP P60 protein
IG197_RS10675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IG197_RS10710	COG4964	Belongs to the GSP D family
IG197_RS10745	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IG197_RS10750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IG197_RS10755	COG1024	Enoyl-CoA hydratase
IG197_RS10760	COG0268	Binds directly to 16S ribosomal RNA
IG197_RS10765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IG197_RS10775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IG197_RS10800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG197_RS10810	COG0735	belongs to the Fur family
IG197_RS10815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IG197_RS10825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IG197_RS10830	COG5001	Diguanylate cyclase
IG197_RS10830	COG3300	MHYT domain
IG197_RS10835	COG2813	Specifically methylates the guanine in position
IG197_RS10840	COG1185	polyribonucleotide nucleotidyltransferase activity
IG197_RS10845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IG197_RS10850	COG0598	Magnesium transport protein CorA
IG197_RS10855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IG197_RS10860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IG197_RS10865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IG197_RS10880	COG0779	Required for maturation of 30S ribosomal subunits
IG197_RS10920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IG197_RS10925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IG197_RS10930	COG1396	sequence-specific DNA binding
IG197_RS10935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IG197_RS10940	COG1253	flavin adenine dinucleotide binding
IG197_RS10945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IG197_RS10950	COG1702	phosphate starvation-inducible protein PhoH
IG197_RS10955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG197_RS10975	COG1214	PFAM Peptidase M22, glycoprotease
IG197_RS10980	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG197_RS11010	COG0481	GTPase activity
IG197_RS11030	COG3220	belongs to the UPF0276 family
IG197_RS11070	COG0671	phosphoesterase, PA-phosphatase related
IG197_RS11080	COG0659	secondary active sulfate transmembrane transporter activity
IG197_RS11085	COG0443	Heat shock 70 kDa protein
IG197_RS11095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IG197_RS11105	COG3795	YCII-related domain
IG197_RS11120	COG0640	Transcriptional regulator
IG197_RS11155	COG0842	Transport permease protein
IG197_RS11160	COG1131	(ABC) transporter
IG197_RS11175	COG2954	triphosphatase activity
IG197_RS11195	COG1420	regulation of RNA biosynthetic process
IG197_RS11200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IG197_RS11210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IG197_RS11215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IG197_RS11235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IG197_RS11240	COG0792	nuclease activity
IG197_RS11250	COG1254	Belongs to the acylphosphatase family
IG197_RS11255	COG2124	cytochrome p450
IG197_RS11285	COG0745	RESPONSE REGULATOR receiver
IG197_RS11290	COG2205	protein histidine kinase activity
IG197_RS11295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IG197_RS11300	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IG197_RS11305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IG197_RS11320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IG197_RS11330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IG197_RS11335	COG2226	methyltransferase
IG197_RS11340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IG197_RS11345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IG197_RS11365	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IG197_RS11380	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS11390	COG3845	ABC transporter
IG197_RS11395	COG2900	Belongs to the SlyX family
IG197_RS11405	COG1744	ABC transporter substrate-binding protein PnrA-like
IG197_RS11410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG197_RS11555	COG1475	DNA binding
IG197_RS11710	COG0577	efflux transmembrane transporter activity
IG197_RS11710	COG1136	(ABC) transporter
IG197_RS11735	COG1278	Cold shock
IG197_RS11775	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS11805	COG0251	oxidation-reduction process
IG197_RS11820	COG0662	Cupin 2, conserved barrel domain protein
IG197_RS11830	COG0848	biopolymer transport protein
IG197_RS11880	COG1082	Xylose isomerase domain protein TIM barrel
IG197_RS11885	COG4607	ABC-type enterochelin transport system periplasmic component
IG197_RS11890	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG197_RS11895	COG4605	iron ion homeostasis
IG197_RS11900	COG4604	ABC transporter, ATP-binding protein
IG197_RS11905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IG197_RS11910	COG4638	Rieske (2fe-2S)
IG197_RS11935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IG197_RS11935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IG197_RS11945	COG4771	TonB-dependent receptor
IG197_RS11950	COG4178	(ABC) transporter
IG197_RS11970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IG197_RS11975	COG0459	protein refolding
IG197_RS12015	COG0395	ABC-type sugar transport system, permease component
IG197_RS12020	COG1175	transmembrane transport
IG197_RS12035	COG1765	OsmC-like protein
IG197_RS12040	COG2766	serine protein kinase
IG197_RS12045	COG2718	Belongs to the UPF0229 family
IG197_RS12050	COG2719	SpoVR family
IG197_RS12055	COG3142	Participates in the control of copper homeostasis
IG197_RS12060	COG1940	carbohydrate kinase activity
IG197_RS12070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS12075	COG1446	asparaginase
IG197_RS12085	COG0765	amino acid transport
IG197_RS12090	COG0765	amino acid transport
IG197_RS12125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IG197_RS12160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG197_RS12165	COG1280	lysine exporter protein (LysE YggA)
IG197_RS12170	COG1957	nucleoside hydrolase
IG197_RS12185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG197_RS12190	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IG197_RS12195	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IG197_RS12200	COG1137	ATPase activity
IG197_RS12205	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IG197_RS12215	COG0616	signal peptide processing
IG197_RS12220	COG0776	regulation of translation
IG197_RS12230	COG2423	ornithine cyclodeaminase activity
IG197_RS12245	COG3547	Transposase (IS116 IS110 IS902 family)
IG197_RS12250	COG2378	regulation of single-species biofilm formation
IG197_RS12255	COG0116	Belongs to the methyltransferase superfamily
IG197_RS12255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IG197_RS12260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IG197_RS12265	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IG197_RS12275	COG5002	protein histidine kinase activity
IG197_RS12275	COG2205	protein histidine kinase activity
IG197_RS12275	COG0784	Response regulator, receiver
IG197_RS12300	COG1252	NADH dehydrogenase
IG197_RS12305	COG2860	membrane
IG197_RS12310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IG197_RS12325	COG0175	sulfate reduction
IG197_RS12330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IG197_RS12340	COG1648	precorrin-2 dehydrogenase activity
IG197_RS12340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IG197_RS12350	COG4651	solute:proton antiporter activity
IG197_RS12350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IG197_RS12375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IG197_RS12400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IG197_RS12405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG197_RS12410	COG1942	4-Oxalocrotonate Tautomerase
IG197_RS12425	COG1733	regulation of RNA biosynthetic process
IG197_RS12435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IG197_RS12435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IG197_RS12450	COG0667	Aldo Keto reductase
IG197_RS12455	COG0673	inositol 2-dehydrogenase activity
IG197_RS12470	COG0395	ABC-type sugar transport system, permease component
IG197_RS12475	COG1175	transmembrane transport
IG197_RS12490	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IG197_RS12505	COG1121	(ABC) transporter
IG197_RS12510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IG197_RS12515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IG197_RS12520	COG3842	ATPase activity
IG197_RS12525	COG0366	Alpha amylase catalytic
IG197_RS12530	COG0395	ABC-type sugar transport system, permease component
IG197_RS12535	COG1175	transmembrane transport
IG197_RS12540	COG1653	transport
IG197_RS12545	COG1609	Transcriptional regulator
IG197_RS12550	COG1802	Transcriptional regulator
IG197_RS12555	COG2272	Belongs to the type-B carboxylesterase lipase family
IG197_RS12560	COG0543	2 iron, 2 sulfur cluster binding
IG197_RS12560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IG197_RS12575	COG1595	DNA-templated transcription, initiation
IG197_RS12585	COG1404	Belongs to the peptidase S8 family
IG197_RS12605	COG3811	Belongs to the UPF0386 family
IG197_RS12625	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS12660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS12670	COG0154	amidase activity
IG197_RS12675	COG0747	negative chemotaxis
IG197_RS12680	COG0601	transmembrane transport
IG197_RS12685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS12710	COG0625	glutathione transferase activity
IG197_RS12800	COG1072	(Pantothenic acid kinase))
IG197_RS12805	COG0625	glutathione transferase activity
IG197_RS12820	COG0829	nickel cation binding
IG197_RS12830	COG3813	Protein conserved in bacteria
IG197_RS12840	COG0832	Belongs to the urease beta subunit family
IG197_RS12865	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IG197_RS12870	COG0830	nickel cation binding
IG197_RS12880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IG197_RS12890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG197_RS12905	COG0534	Mate efflux family protein
IG197_RS12920	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS12925	COG3842	ATPase activity
IG197_RS12935	COG0765	amino acid transport
IG197_RS12940	COG0765	amino acid transport
IG197_RS12955	COG0583	DNA-binding transcription factor activity
IG197_RS12960	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IG197_RS12985	COG1129	ABC transporter
IG197_RS13000	COG1335	isochorismatase
IG197_RS13030	COG1846	Transcriptional regulator
IG197_RS13035	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS13040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IG197_RS13065	COG0673	inositol 2-dehydrogenase activity
IG197_RS13070	COG0395	ABC-type sugar transport system, permease component
IG197_RS13085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IG197_RS13090	COG2971	BadF BadG BcrA BcrD
IG197_RS13095	COG2188	Transcriptional regulator
IG197_RS13100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IG197_RS13105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IG197_RS13130	COG1879	ABC-type sugar transport system periplasmic component
IG197_RS13140	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS13150	COG1609	Transcriptional regulator
IG197_RS13160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG197_RS13170	COG4941	Belongs to the sigma-70 factor family
IG197_RS13175	COG3795	YCII-related domain
IG197_RS13180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IG197_RS13230	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IG197_RS13235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IG197_RS13240	COG4335	DNA alkylation repair
IG197_RS13260	COG0121	glutamine amidotransferase
IG197_RS13270	COG1522	sequence-specific DNA binding
IG197_RS13275	COG0756	dUTP diphosphatase activity
IG197_RS13280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG197_RS13285	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IG197_RS13295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG197_RS13300	COG0281	malic enzyme
IG197_RS13300	COG0280	phosphate acetyltransferase
IG197_RS13305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IG197_RS13340	COG0596	Alpha beta hydrolase
IG197_RS13350	COG2207	Transcriptional regulator
IG197_RS13350	COG0662	Cupin 2, conserved barrel domain protein
IG197_RS13385	COG5001	Diguanylate cyclase
IG197_RS13385	COG5002	protein histidine kinase activity
IG197_RS13395	COG0656	L-ascorbic acid biosynthetic process
IG197_RS13415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IG197_RS13420	COG0728	peptidoglycan biosynthetic process
IG197_RS13435	COG0463	Glycosyl transferase, family 2
IG197_RS13435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IG197_RS13440	COG0180	Tryptophanyl-tRNA synthetase
IG197_RS13450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IG197_RS13455	COG1376	ErfK ybiS ycfS ynhG family protein
IG197_RS13465	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IG197_RS13475	COG1643	Atp-dependent helicase
IG197_RS13485	COG0673	inositol 2-dehydrogenase activity
IG197_RS13490	COG1737	Transcriptional regulator
IG197_RS13495	COG0129	dihydroxy-acid dehydratase activity
IG197_RS13510	COG0626	cystathionine gamma-synthase activity
IG197_RS13515	COG1846	Transcriptional regulator
IG197_RS13520	COG0697	spore germination
IG197_RS13540	COG3842	ATPase activity
IG197_RS13560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG197_RS13580	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS13590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG197_RS13595	COG1802	Transcriptional regulator
IG197_RS13600	COG0579	oxidoreductase
IG197_RS13610	COG1522	sequence-specific DNA binding
IG197_RS13615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IG197_RS13625	COG2186	Transcriptional regulator
IG197_RS13630	COG0626	cystathionine gamma-synthase activity
IG197_RS13645	COG0395	ABC-type sugar transport system, permease component
IG197_RS13650	COG3842	ATPase activity
IG197_RS13655	COG0840	transmembrane signaling receptor activity
IG197_RS13665	COG0745	RESPONSE REGULATOR receiver
IG197_RS13675	COG0835	chemotaxis
IG197_RS13680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IG197_RS13690	COG0745	RESPONSE REGULATOR receiver
IG197_RS13695	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IG197_RS13780	COG0156	8-amino-7-oxononanoate synthase activity
IG197_RS13785	COG1063	alcohol dehydrogenase
IG197_RS13795	COG4608	Belongs to the ABC transporter superfamily
IG197_RS13805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS13810	COG0601	transmembrane transport
IG197_RS13825	COG2186	Transcriptional regulator
IG197_RS13840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG197_RS13845	COG0346	lactoylglutathione lyase activity
IG197_RS13850	COG0346	lactoylglutathione lyase activity
IG197_RS13860	COG2124	cytochrome p450
IG197_RS13885	COG1846	Transcriptional regulator
IG197_RS13890	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG197_RS13905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS13940	COG0436	Aminotransferase
IG197_RS13955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG197_RS13965	COG1473	amidohydrolase
IG197_RS13975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IG197_RS13985	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS13990	COG3842	ATPase activity
IG197_RS13995	COG1177	transmembrane transport
IG197_RS14000	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS14025	COG0156	8-amino-7-oxononanoate synthase activity
IG197_RS14035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS14040	COG0601	transmembrane transport
IG197_RS14060	COG4172	Belongs to the ABC transporter superfamily
IG197_RS14080	COG0747	negative chemotaxis
IG197_RS14085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG197_RS14110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IG197_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS14120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IG197_RS14125	COG0539	negative regulation of cytoplasmic translation
IG197_RS14145	COG1309	transcriptional regulator
IG197_RS14155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS14160	COG4215	(ABC) transporter
IG197_RS14170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IG197_RS14200	COG1968	undecaprenyl-diphosphatase activity
IG197_RS14210	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IG197_RS14220	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IG197_RS14225	COG1803	Methylglyoxal synthase
IG197_RS14230	COG0837	glucose binding
IG197_RS14235	COG1132	(ABC) transporter
IG197_RS14240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IG197_RS14245	COG0588	phosphoglycerate mutase activity
IG197_RS14295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IG197_RS14305	COG3386	PFAM SMP-30 Gluconolaconase
IG197_RS14310	COG0800	Aldolase
IG197_RS14315	COG3734	2-keto-3-deoxy-galactonokinase
IG197_RS14320	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS14325	COG5001	Diguanylate cyclase
IG197_RS14335	COG1309	transcriptional regulator
IG197_RS14340	COG0189	ligase activity
IG197_RS14355	COG5002	protein histidine kinase activity
IG197_RS14355	COG5001	Diguanylate cyclase
IG197_RS14355	COG3447	MASE1 domain protein
IG197_RS14380	COG0284	orotidine-5'-phosphate decarboxylase activity
IG197_RS14390	COG3963	phosphatidate phosphatase activity
IG197_RS14395	COG0484	heat shock protein binding
IG197_RS14405	COG0443	Heat shock 70 kDa protein
IG197_RS14430	COG3038	cytochrome b561
IG197_RS14440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IG197_RS14440	COG0072	phenylalanine-tRNA ligase activity
IG197_RS14450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IG197_RS14455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IG197_RS14460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IG197_RS14470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IG197_RS14480	COG3135	benzoate transporter
IG197_RS14495	COG0583	DNA-binding transcription factor activity
IG197_RS14500	COG0135	phosphoribosylanthranilate isomerase activity
IG197_RS14505	COG0133	tryptophan synthase activity
IG197_RS14510	COG0159	tryptophan synthase activity
IG197_RS14515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IG197_RS14530	COG1074	ATP-dependent DNA helicase activity
IG197_RS14540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IG197_RS14545	COG3178	'Phosphotransferase
IG197_RS14550	COG2205	protein histidine kinase activity
IG197_RS14555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IG197_RS14560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG197_RS14565	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG197_RS14565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IG197_RS14575	COG2205	protein histidine kinase activity
IG197_RS14580	COG0745	RESPONSE REGULATOR receiver
IG197_RS14585	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IG197_RS14595	COG1652	LysM domain
IG197_RS14605	COG1072	(Pantothenic acid kinase))
IG197_RS14610	COG0140	phosphoribosyl-ATP diphosphatase activity
IG197_RS14620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IG197_RS14630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IG197_RS14640	COG0131	Imidazoleglycerol-phosphate dehydratase
IG197_RS14645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IG197_RS14665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IG197_RS14675	COG3800	Transcriptional regulator
IG197_RS14675	COG1396	sequence-specific DNA binding
IG197_RS14695	COG3030	protein affecting phage T7 exclusion by the F plasmid
IG197_RS14700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IG197_RS14710	COG0237	dephospho-CoA kinase activity
IG197_RS14715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IG197_RS14720	COG0424	maF-like protein
IG197_RS14725	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IG197_RS14730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IG197_RS14735	COG1981	membrane
IG197_RS14740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IG197_RS14745	COG1331	Highly conserved protein containing a thioredoxin domain
IG197_RS14750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IG197_RS14755	COG0445	tRNA wobble uridine modification
IG197_RS14830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IG197_RS14840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG197_RS14840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IG197_RS14845	COG4770	biotin carboxylase activity
IG197_RS14850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IG197_RS14860	COG1396	sequence-specific DNA binding
IG197_RS14860	COG3800	Transcriptional regulator
IG197_RS14870	COG2183	response to ionizing radiation
IG197_RS14875	COG0137	argininosuccinate synthase activity
IG197_RS14905	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IG197_RS14910	COG1605	Chorismate mutase
IG197_RS14910	COG0287	Prephenate dehydrogenase
IG197_RS14915	COG0228	four-way junction DNA binding
IG197_RS14920	COG5001	Diguanylate cyclase
IG197_RS14920	COG3300	MHYT domain
IG197_RS14930	COG3781	membrane
IG197_RS14945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IG197_RS14960	COG4178	(ABC) transporter
IG197_RS14970	COG0473	3-isopropylmalate dehydrogenase activity
IG197_RS14980	COG0251	oxidation-reduction process
IG197_RS14990	COG0066	3-isopropylmalate dehydratase activity
IG197_RS15000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IG197_RS15005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG197_RS15010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG197_RS15015	COG1120	ATPase activity
IG197_RS15020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IG197_RS15030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG197_RS15035	COG0525	valine-tRNA ligase activity
IG197_RS15040	COG0765	amino acid transport
IG197_RS15045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS15060	COG2814	Major facilitator Superfamily
IG197_RS15090	COG1595	DNA-templated transcription, initiation
IG197_RS15125	COG2195	Cleaves the N-terminal amino acid of tripeptides
IG197_RS15140	COG2301	Belongs to the HpcH HpaI aldolase family
IG197_RS15165	COG0587	DNA-directed DNA polymerase activity
IG197_RS15170	COG2835	tetraacyldisaccharide 4'-kinase activity
IG197_RS15175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IG197_RS15180	COG3118	belongs to the thioredoxin family
IG197_RS15200	COG0010	Belongs to the arginase family
IG197_RS15205	COG0436	Aminotransferase
IG197_RS15220	COG0477	Major facilitator Superfamily
IG197_RS15230	COG0463	Glycosyl transferase, family 2
IG197_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS15245	COG4948	Mandelate Racemase Muconate Lactonizing
IG197_RS15250	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG197_RS15260	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS15265	COG1129	ABC transporter
IG197_RS15275	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS15285	COG4154	Belongs to the RbsD FucU family
IG197_RS15290	COG4608	Belongs to the ABC transporter superfamily
IG197_RS15295	COG0444	Belongs to the ABC transporter superfamily
IG197_RS15300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS15305	COG0601	transmembrane transport
IG197_RS15310	COG0747	negative chemotaxis
IG197_RS15320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IG197_RS15335	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IG197_RS15355	COG3339	Conserved Protein
IG197_RS15360	COG2154	pterin-4-alpha-carbinolamine dehydratase
IG197_RS15365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IG197_RS15380	COG1136	(ABC) transporter
IG197_RS15385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IG197_RS15390	COG0670	Belongs to the BI1 family
IG197_RS15400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG197_RS15405	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS15425	COG2372	response to copper ion
IG197_RS15425	COG1276	copper resistance
IG197_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS15445	COG3300	MHYT domain
IG197_RS15445	COG5001	Diguanylate cyclase
IG197_RS15480	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IG197_RS15490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IG197_RS15495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IG197_RS15500	COG0552	protein localization to endoplasmic reticulum
IG197_RS15505	COG2917	probably involved in intracellular septation
IG197_RS15515	COG0431	NADPH-dependent FMN reductase
IG197_RS15530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG197_RS15540	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IG197_RS15545	COG4133	protoheme IX ABC transporter activity
IG197_RS15550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IG197_RS15560	COG0039	L-malate dehydrogenase activity
IG197_RS15565	COG0045	succinate-CoA ligase (ADP-forming) activity
IG197_RS15575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IG197_RS15585	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS15600	COG1280	lysine exporter protein (LysE YggA)
IG197_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS15635	COG4974	Belongs to the 'phage' integrase family
IG197_RS15640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IG197_RS15645	COG0336	Belongs to the RNA methyltransferase TrmD family
IG197_RS15655	COG0335	large ribosomal subunit rRNA binding
IG197_RS15660	COG0456	acetyltransferase
IG197_RS15680	COG0765	amino acid transport
IG197_RS15715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IG197_RS15730	COG2009	succinate dehydrogenase
IG197_RS15760	COG3132	Protein of unknown function, DUF480
IG197_RS15780	COG1764	response to oxidative stress
IG197_RS15785	COG3795	YCII-related domain
IG197_RS15790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG197_RS15795	COG1946	Acyl-CoA thioesterase
IG197_RS15800	COG0347	Belongs to the P(II) protein family
IG197_RS15805	COG0004	ammonium transporteR
IG197_RS15825	COG2261	transglycosylase associated protein
IG197_RS15825	COG1674	ftsk spoiiie
IG197_RS15830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IG197_RS15845	COG0745	RESPONSE REGULATOR receiver
IG197_RS15860	COG0583	DNA-binding transcription factor activity
IG197_RS15865	COG2264	protein methyltransferase activity
IG197_RS15880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IG197_RS15885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IG197_RS15890	COG0181	hydroxymethylbilane synthase activity
IG197_RS15915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IG197_RS15940	COG3307	-O-antigen
IG197_RS15945	COG1596	polysaccharide export
IG197_RS15960	COG1215	transferase activity, transferring glycosyl groups
IG197_RS15970	COG2273	Hydrolase Family 16
IG197_RS15985	COG0438	transferase activity, transferring glycosyl groups
IG197_RS16000	COG0438	transferase activity, transferring glycosyl groups
IG197_RS16005	COG1215	transferase activity, transferring glycosyl groups
IG197_RS16010	COG1215	transferase activity, transferring glycosyl groups
IG197_RS16015	COG1215	transferase activity, transferring glycosyl groups
IG197_RS16020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IG197_RS16025	COG0489	protein tyrosine kinase activity
IG197_RS16025	COG3206	protein involved in exopolysaccharide biosynthesis
IG197_RS16030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IG197_RS16040	COG3920	Histidine kinase
IG197_RS16045	COG2755	lipolytic protein G-D-S-L family
IG197_RS16045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG197_RS16055	COG3239	Fatty acid desaturase
IG197_RS16070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG197_RS16075	COG0747	negative chemotaxis
IG197_RS16080	COG0601	transmembrane transport
IG197_RS16085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS16090	COG4172	Belongs to the ABC transporter superfamily
IG197_RS16105	COG3284	Transcriptional regulator
IG197_RS16130	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS16140	COG3119	arylsulfatase activity
IG197_RS16160	COG1940	carbohydrate kinase activity
IG197_RS16165	COG0730	response to heat
IG197_RS16170	COG1879	ABC-type sugar transport system periplasmic component
IG197_RS16175	COG1802	Transcriptional regulator
IG197_RS16180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG197_RS16195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG197_RS16205	COG0778	Nitroreductase
IG197_RS16215	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG197_RS16230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS16245	COG2972	Histidine kinase
IG197_RS16245	COG0840	transmembrane signaling receptor activity
IG197_RS16255	COG0601	transmembrane transport
IG197_RS16260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS16270	COG1228	amidohydrolase
IG197_RS16275	COG0444	Belongs to the ABC transporter superfamily
IG197_RS16280	COG4608	Belongs to the ABC transporter superfamily
IG197_RS16285	COG1802	Transcriptional regulator
IG197_RS16290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG197_RS16300	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS16305	COG0747	negative chemotaxis
IG197_RS16310	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS16315	COG0583	DNA-binding transcription factor activity
IG197_RS16320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS16325	COG0765	amino acid transport
IG197_RS16335	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS16350	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS16410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG197_RS16415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG197_RS16425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IG197_RS16440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG197_RS16445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG197_RS16475	COG0832	Belongs to the urease beta subunit family
IG197_RS16480	COG0804	urea catabolic process
IG197_RS16490	COG0830	nickel cation binding
IG197_RS16495	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IG197_RS16500	COG0829	nickel cation binding
IG197_RS16530	COG2197	response regulator
IG197_RS16540	COG0457	Tetratricopeptide repeat
IG197_RS16540	COG3710	Transcriptional regulator
IG197_RS16570	COG0583	DNA-binding transcription factor activity
IG197_RS16590	COG0583	DNA-binding transcription factor activity
IG197_RS16620	COG5001	Diguanylate cyclase
IG197_RS16630	COG4957	zinc ion binding
IG197_RS16635	COG2199	diguanylate cyclase activity
IG197_RS16665	COG0010	Belongs to the arginase family
IG197_RS16695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG197_RS16710	COG0765	amino acid transport
IG197_RS16720	COG0281	malic enzyme
IG197_RS16720	COG0280	phosphate acetyltransferase
IG197_RS16735	COG3842	ATPase activity
IG197_RS16745	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS16785	COG5410	chromosome segregation
IG197_RS16800	COG1525	nuclease
IG197_RS16850	COG4957	zinc ion binding
IG197_RS16885	COG1872	DUF167
IG197_RS16895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IG197_RS16915	COG1704	LemA family
IG197_RS16940	COG2814	Major facilitator Superfamily
IG197_RS16945	COG1846	Transcriptional regulator
IG197_RS16950	COG0339	signal peptide processing
IG197_RS16960	COG1217	gtp-binding protein TYPA
IG197_RS16980	COG2270	Major facilitator Superfamily
IG197_RS16985	COG0138	bifunctional purine biosynthesis protein purh
IG197_RS16995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IG197_RS16995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IG197_RS17000	COG0501	Belongs to the peptidase M48B family
IG197_RS17025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG197_RS17030	COG0789	Transcriptional regulator
IG197_RS17040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG197_RS17045	COG5425	PFAM Usg family protein
IG197_RS17055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IG197_RS17060	COG0495	leucyl-tRNA aminoacylation
IG197_RS17070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IG197_RS17080	COG1522	sequence-specific DNA binding
IG197_RS17085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IG197_RS17105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IG197_RS17115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IG197_RS17120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IG197_RS17125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IG197_RS17130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG197_RS17135	COG0590	tRNA wobble adenosine to inosine editing
IG197_RS17150	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IG197_RS17155	COG1088	dTDP-glucose 4,6-dehydratase activity
IG197_RS17160	COG1091	dTDP-4-dehydrorhamnose reductase activity
IG197_RS17170	COG3754	Rhamnan synthesis protein F
IG197_RS17195	COG3743	rRNA binding
IG197_RS17195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IG197_RS17200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IG197_RS17215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IG197_RS17220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IG197_RS17225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IG197_RS17230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IG197_RS17245	COG0799	negative regulation of ribosome biogenesis
IG197_RS17250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IG197_RS17260	COG0793	Belongs to the peptidase S41A family
IG197_RS17270	COG0494	nUDIX hydrolase
IG197_RS17275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG197_RS17285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS17310	COG3655	Transcriptional regulator
IG197_RS17335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG197_RS17340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS17385	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IG197_RS17395	COG2223	nitrite transmembrane transporter activity
IG197_RS17400	COG0583	DNA-binding transcription factor activity
IG197_RS17420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IG197_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS17445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IG197_RS17450	COG0741	lytic transglycosylase activity
IG197_RS17455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IG197_RS17475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IG197_RS17480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IG197_RS17495	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IG197_RS17500	COG0183	Belongs to the thiolase family
IG197_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS17510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IG197_RS17525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IG197_RS17530	COG1329	Transcriptional regulator
IG197_RS17545	COG1126	abc transporter atp-binding protein
IG197_RS17550	COG0765	amino acid transport
IG197_RS17555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS17560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IG197_RS17570	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IG197_RS17590	COG0488	(ABC) transporter
IG197_RS17605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IG197_RS17615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IG197_RS17620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IG197_RS17645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IG197_RS17665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IG197_RS17670	COG0037	tRNA processing
IG197_RS17680	COG2885	chlorophyll binding
IG197_RS17695	COG0848	biopolymer transport protein
IG197_RS17705	COG0824	Thioesterase
IG197_RS17710	COG2226	methyltransferase
IG197_RS17720	COG1408	metallophosphoesterase
IG197_RS17730	COG2255	four-way junction helicase activity
IG197_RS17755	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IG197_RS17775	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS17795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IG197_RS17800	COG0483	inositol monophosphate 1-phosphatase activity
IG197_RS17805	COG1272	protein, Hemolysin III
IG197_RS17850	COG0778	Nitroreductase
IG197_RS17855	COG1132	(ABC) transporter
IG197_RS17860	COG0254	rRNA binding
IG197_RS17870	COG0702	epimerase
IG197_RS17880	COG1181	Belongs to the D-alanine--D-alanine ligase family
IG197_RS17890	COG0217	transcriptional regulatory protein
IG197_RS17910	COG1733	regulation of RNA biosynthetic process
IG197_RS17930	COG0305	Participates in initiation and elongation during chromosome replication
IG197_RS17935	COG0861	Integral membrane protein TerC family
IG197_RS17940	COG1692	metallophosphoesterase
IG197_RS17945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IG197_RS17980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG197_RS18000	COG0583	DNA-binding transcription factor activity
IG197_RS18005	COG0431	NADPH-dependent FMN reductase
IG197_RS18010	COG3750	Belongs to the UPF0335 family
IG197_RS18030	COG0469	pyruvate kinase activity
IG197_RS18035	COG2267	carboxylic ester hydrolase activity
IG197_RS18040	COG0457	Tetratricopeptide repeat
IG197_RS18045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IG197_RS18050	COG3755	Protein conserved in bacteria
IG197_RS18055	COG1733	regulation of RNA biosynthetic process
IG197_RS18070	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IG197_RS18090	COG0640	Transcriptional regulator
IG197_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS18105	COG0604	alcohol dehydrogenase
IG197_RS18105	COG3321	synthase
IG197_RS18110	COG2226	methyltransferase
IG197_RS18120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS18130	COG0145	ligase activity
IG197_RS18135	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
IG197_RS18165	COG1042	CoA-binding domain protein
IG197_RS18165	COG0045	succinate-CoA ligase (ADP-forming) activity
IG197_RS18165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IG197_RS18175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG197_RS18180	COG0697	spore germination
IG197_RS18195	COG0183	Belongs to the thiolase family
IG197_RS18215	COG4191	Histidine kinase
IG197_RS18240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG197_RS18330	COG2268	Band 7 protein
IG197_RS18385	COG3685	Protein conserved in bacteria
IG197_RS18430	COG3588	fructose-bisphosphate aldolase
IG197_RS18440	COG0126	phosphoglycerate kinase activity
IG197_RS18480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IG197_RS18485	COG0564	pseudouridine synthase activity
IG197_RS18495	COG0346	lactoylglutathione lyase activity
IG197_RS18570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IG197_RS18575	COG0573	inorganic phosphate transmembrane transporter activity
IG197_RS18585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IG197_RS18590	COG0704	Plays a role in the regulation of phosphate uptake
IG197_RS18595	COG0745	RESPONSE REGULATOR receiver
IG197_RS18605	COG4213	ABC transporter substrate-binding protein
IG197_RS18610	COG4214	carbohydrate transport
IG197_RS18635	COG3920	Histidine kinase
IG197_RS18635	COG2202	Pas domain
IG197_RS18645	COG0784	Response regulator, receiver
IG197_RS18660	COG0784	Response regulator, receiver
IG197_RS18665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG197_RS18670	COG0628	permease
IG197_RS18705	COG0346	lactoylglutathione lyase activity
IG197_RS18710	COG0400	carboxylic ester hydrolase activity
IG197_RS18730	COG2203	Gaf domain
IG197_RS18730	COG2200	EAL domain
IG197_RS18730	COG2199	diguanylate cyclase activity
IG197_RS18735	COG0745	RESPONSE REGULATOR receiver
IG197_RS18740	COG0745	RESPONSE REGULATOR receiver
IG197_RS18755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG197_RS18760	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IG197_RS18765	COG3833	ABC-type maltose transport systems, permease component
IG197_RS18770	COG3842	ATPase activity
IG197_RS18795	COG0483	inositol monophosphate 1-phosphatase activity
IG197_RS18810	COG1609	Transcriptional regulator
IG197_RS18820	COG1840	ABC-type Fe3 transport system, periplasmic component
IG197_RS18830	COG3842	ATPase activity
IG197_RS18835	COG1238	metal cluster binding
IG197_RS18845	COG2132	Multicopper oxidase
IG197_RS18880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IG197_RS18885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IG197_RS18895	COG1845	cytochrome c oxidase, subunit III
IG197_RS18910	COG0406	alpha-ribazole phosphatase activity
IG197_RS18915	COG3842	ATPase activity
IG197_RS18920	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IG197_RS18940	COG1737	Transcriptional regulator
IG197_RS18950	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS18965	COG0395	ABC-type sugar transport system, permease component
IG197_RS18975	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS18980	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG197_RS18985	COG3845	ABC transporter
IG197_RS18995	COG2186	Transcriptional regulator
IG197_RS19015	COG0625	glutathione transferase activity
IG197_RS19020	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IG197_RS19025	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IG197_RS19030	COG0352	thiamine-phosphate diphosphorylase activity
IG197_RS19030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IG197_RS19030	COG0351	phosphomethylpyrimidine kinase
IG197_RS19040	COG2022	thiamine diphosphate biosynthetic process
IG197_RS19055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IG197_RS19080	COG0356	it plays a direct role in the translocation of protons across the membrane
IG197_RS19095	COG1473	amidohydrolase
IG197_RS19100	COG1686	Belongs to the peptidase S11 family
IG197_RS19105	COG0523	cobalamin synthesis protein
IG197_RS19110	COG0425	Belongs to the sulfur carrier protein TusA family
IG197_RS19120	COG0825	malonyl-CoA metabolic process
IG197_RS19135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IG197_RS19140	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IG197_RS19145	COG4536	flavin adenine dinucleotide binding
IG197_RS19200	COG1522	sequence-specific DNA binding
IG197_RS19225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IG197_RS19230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IG197_RS19250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG197_RS19255	COG2226	methyltransferase
IG197_RS19270	COG1597	lipid kinase activity
IG197_RS19275	COG4178	(ABC) transporter
IG197_RS19280	COG2814	Major facilitator Superfamily
IG197_RS19285	COG0583	DNA-binding transcription factor activity
IG197_RS19305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS19310	COG1309	transcriptional regulator
IG197_RS19340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IG197_RS19345	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS19365	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IG197_RS19370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG197_RS19375	COG0287	Prephenate dehydrogenase
IG197_RS19415	COG2884	Cell division ATP-binding protein ftsE
IG197_RS19425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IG197_RS19440	COG0583	DNA-binding transcription factor activity
IG197_RS19455	COG0019	diaminopimelate decarboxylase activity
IG197_RS19465	COG0165	Argininosuccinate lyase
IG197_RS19470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IG197_RS19475	COG1653	transport
IG197_RS19480	COG1175	transmembrane transport
IG197_RS19485	COG0395	ABC-type sugar transport system, permease component
IG197_RS19490	COG3842	ATPase activity
IG197_RS19500	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG197_RS19505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IG197_RS19510	COG2086	electron transfer activity
IG197_RS19530	COG0300	oxidoreductase activity
IG197_RS19540	COG0697	spore germination
IG197_RS19550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IG197_RS19570	COG1238	metal cluster binding
IG197_RS19605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG197_RS19625	COG2239	Acts as a magnesium transporter
IG197_RS19630	COG0653	protein targeting
IG197_RS19635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IG197_RS19655	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IG197_RS19660	COG0456	acetyltransferase
IG197_RS19665	COG0494	nUDIX hydrolase
IG197_RS19680	COG2226	methyltransferase
IG197_RS19685	COG1040	competence protein
IG197_RS19695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG197_RS19720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG197_RS19725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG197_RS19730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG197_RS19735	COG0527	aspartate kinase activity
IG197_RS19745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IG197_RS19750	COG2890	protein-(glutamine-N5) methyltransferase activity
IG197_RS19760	COG0542	response to heat
IG197_RS19770	COG1376	ErfK ybiS ycfS ynhG family protein
IG197_RS19800	COG0625	glutathione transferase activity
IG197_RS19805	COG0477	Major facilitator Superfamily
IG197_RS19810	COG0739	heme binding
IG197_RS19810	COG0741	lytic transglycosylase activity
IG197_RS19810	COG1196	nuclear chromosome segregation
IG197_RS19900	COG4964	Belongs to the GSP D family
IG197_RS19925	COG1376	ErfK ybiS ycfS ynhG family protein
IG197_RS19950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IG197_RS19950	COG2755	lipolytic protein G-D-S-L family
IG197_RS20000	COG4957	zinc ion binding
IG197_RS20040	COG0464	growth
IG197_RS20060	COG4176	ABC-type proline glycine betaine transport system permease component
IG197_RS20065	COG4175	Glycine betaine
IG197_RS20065	COG3448	diguanylate cyclase activity
IG197_RS20075	COG0745	RESPONSE REGULATOR receiver
IG197_RS20080	COG2205	protein histidine kinase activity
IG197_RS20090	COG0745	RESPONSE REGULATOR receiver
IG197_RS20100	COG1879	ABC-type sugar transport system periplasmic component
IG197_RS20105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS20110	COG3842	ATPase activity
IG197_RS20130	COG1070	Carbohydrate kinase
IG197_RS20140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IG197_RS20145	COG0667	Aldo Keto reductase
IG197_RS20155	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS20160	COG1129	ABC transporter
IG197_RS20180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS20190	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IG197_RS20230	COG0463	Glycosyl transferase, family 2
IG197_RS20235	COG1215	transferase activity, transferring glycosyl groups
IG197_RS20250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG197_RS20255	COG1120	ATPase activity
IG197_RS20260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG197_RS20275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG197_RS20280	COG0205	6-phosphofructokinase activity
IG197_RS20285	COG1388	LysM domain
IG197_RS20285	COG1376	ErfK ybiS ycfS ynhG family protein
IG197_RS20290	COG1280	lysine exporter protein (LysE YggA)
IG197_RS20300	COG1070	Carbohydrate kinase
IG197_RS20310	COG2115	Belongs to the xylose isomerase family
IG197_RS20330	COG4977	sequence-specific DNA binding
IG197_RS20335	COG3246	L-lysine catabolic process to acetate
IG197_RS20340	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG197_RS20345	COG1960	acyl-CoA dehydrogenase activity
IG197_RS20360	COG0657	acetylesterase activity
IG197_RS20370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS20395	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IG197_RS20400	COG3257	ureidoglycine aminohydrolase activity
IG197_RS20410	COG2351	hydroxyisourate hydrolase activity
IG197_RS20420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IG197_RS20430	COG0783	Belongs to the Dps family
IG197_RS20445	COG0583	DNA-binding transcription factor activity
IG197_RS20455	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS20460	COG4702	Belongs to the UPF0303 family
IG197_RS20480	COG0174	glutamine synthetase
IG197_RS20485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IG197_RS20510	COG0523	cobalamin synthesis protein
IG197_RS20520	COG1846	Transcriptional regulator
IG197_RS20535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG197_RS20550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IG197_RS20555	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IG197_RS20560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IG197_RS20570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IG197_RS20570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IG197_RS20600	COG5001	Diguanylate cyclase
IG197_RS20640	COG1280	lysine exporter protein (LysE YggA)
IG197_RS20650	COG2249	NAD(P)H dehydrogenase (quinone) activity
IG197_RS20660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IG197_RS20680	COG2223	nitrite transmembrane transporter activity
IG197_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS20705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS20720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS20720	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS20810	COG3842	ATPase activity
IG197_RS20815	COG0583	DNA-binding transcription factor activity
IG197_RS20820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IG197_RS20825	COG3842	ATPase activity
IG197_RS20830	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS20835	COG1177	transmembrane transport
IG197_RS20840	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS20855	COG1609	Transcriptional regulator
IG197_RS20870	COG1024	Enoyl-CoA hydratase
IG197_RS20875	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS20880	COG1653	transport
IG197_RS20890	COG0395	ABC-type sugar transport system, permease component
IG197_RS20895	COG3842	ATPase activity
IG197_RS20905	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS20915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IG197_RS20920	COG3774	pathogenesis
IG197_RS20925	COG4608	Belongs to the ABC transporter superfamily
IG197_RS20930	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS20935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS20945	COG0747	negative chemotaxis
IG197_RS20950	COG0444	Belongs to the ABC transporter superfamily
IG197_RS20980	COG2072	flavoprotein involved in K transport
IG197_RS21010	COG0071	Belongs to the small heat shock protein (HSP20) family
IG197_RS21020	COG0070	glutamate synthase
IG197_RS21020	COG0069	glutamate synthase activity
IG197_RS21020	COG0067	glutamate synthase
IG197_RS21035	COG2951	lytic endotransglycosylase activity
IG197_RS21040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IG197_RS21045	COG0778	Nitroreductase
IG197_RS21070	COG1585	Membrane protein implicated in regulation of membrane protease activity
IG197_RS21075	COG0330	HflC and HflK could
IG197_RS21080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS21080	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IG197_RS21085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IG197_RS21090	COG0737	Belongs to the 5'-nucleotidase family
IG197_RS21100	COG3775	system Galactitol-specific IIC component
IG197_RS21115	COG5310	Homospermidine synthase
IG197_RS21145	COG2204	response regulator
IG197_RS21150	COG3108	Peptidase M15
IG197_RS21155	COG0800	Aldolase
IG197_RS21165	COG1054	Belongs to the UPF0176 family
IG197_RS21175	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS21235	COG0583	DNA-binding transcription factor activity
IG197_RS21240	COG0154	amidase activity
IG197_RS21290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG197_RS21295	COG2814	Major facilitator Superfamily
IG197_RS21305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IG197_RS21310	COG5443	negative regulation of bacterial-type flagellum assembly
IG197_RS21315	COG5442	Flagellar protein FlaF
IG197_RS21330	COG1749	Flagellar hook protein flgE
IG197_RS21370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IG197_RS21375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IG197_RS21380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IG197_RS21385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IG197_RS21390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IG197_RS21395	COG1338	Plays a role in the flagellum-specific transport system
IG197_RS21405	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IG197_RS21415	COG1706	bacterial-type flagellum-dependent cell motility
IG197_RS21420	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
IG197_RS21425	COG4786	Flagellar basal body rod
IG197_RS21430	COG1677	Flagellar hook-basal body complex protein FliE
IG197_RS21435	COG1558	bacterial-type flagellum-dependent cell motility
IG197_RS21440	COG1815	bacterial-type flagellum-dependent cell motility
IG197_RS21450	COG1157	protein secretion by the type III secretion system
IG197_RS21455	COG4786	Flagellar basal body rod
IG197_RS21465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IG197_RS21475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IG197_RS21480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IG197_RS21485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IG197_RS21500	COG2771	luxR family
IG197_RS21515	COG1309	transcriptional regulator
IG197_RS21535	COG3842	ATPase activity
IG197_RS21545	COG1177	transmembrane transport
IG197_RS21575	COG4213	ABC transporter substrate-binding protein
IG197_RS21580	COG1129	ABC transporter
IG197_RS21585	COG4214	carbohydrate transport
IG197_RS21635	COG1129	ABC transporter
IG197_RS21640	COG4211	Belongs to the binding-protein-dependent transport system permease family
IG197_RS21645	COG0673	inositol 2-dehydrogenase activity
IG197_RS21650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG197_RS21655	COG3962	Belongs to the TPP enzyme family
IG197_RS21660	COG1082	Xylose isomerase domain protein TIM barrel
IG197_RS21670	COG3718	enzyme involved in inositol metabolism
IG197_RS21675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IG197_RS21705	COG2197	response regulator
IG197_RS21725	COG0747	negative chemotaxis
IG197_RS21750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG197_RS21755	COG0747	negative chemotaxis
IG197_RS21770	COG3454	Phosphonate metabolism
IG197_RS21775	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IG197_RS21780	COG3639	organic phosphonate transmembrane transporter activity
IG197_RS21795	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IG197_RS21805	COG1733	regulation of RNA biosynthetic process
IG197_RS21835	COG4778	phosphonate C-P lyase system protein PhnL
IG197_RS21840	COG4107	phosphonate C-P lyase system protein PhnK
IG197_RS21845	COG3627	carbon phosphorus lyase activity
IG197_RS21850	COG3626	phosphonate metabolism
IG197_RS21855	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IG197_RS21860	COG3624	Phosphonate C-P lyase system protein PhnG
IG197_RS21865	COG2188	Transcriptional regulator
IG197_RS21880	COG1177	transmembrane transport
IG197_RS21890	COG2072	flavoprotein involved in K transport
IG197_RS21905	COG3620	sequence-specific DNA binding
IG197_RS21935	COG0583	DNA-binding transcription factor activity
IG197_RS21940	COG3842	ATPase activity
IG197_RS21950	COG1175	transmembrane transport
IG197_RS21990	COG0482	sulfurtransferase activity
IG197_RS22005	COG0604	alcohol dehydrogenase
IG197_RS22010	COG1733	regulation of RNA biosynthetic process
IG197_RS22025	COG2201	protein-glutamate methylesterase activity
IG197_RS22070	COG0435	Glutathione S-transferase
IG197_RS22075	COG0494	nUDIX hydrolase
IG197_RS22090	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS22090	COG0596	Alpha beta hydrolase
IG197_RS22100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IG197_RS22110	COG3180	Ammonia monooxygenase
IG197_RS22155	COG0512	Glutamine amidotransferase of anthranilate synthase
IG197_RS22155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IG197_RS22160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG197_RS22170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IG197_RS22175	COG2814	Major facilitator Superfamily
IG197_RS22180	COG0583	DNA-binding transcription factor activity
IG197_RS22185	COG4993	Dehydrogenase
IG197_RS22195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IG197_RS22215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IG197_RS22250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IG197_RS22285	COG1435	thymidine kinase activity
IG197_RS22295	COG4176	ABC-type proline glycine betaine transport system permease component
IG197_RS22300	COG4175	Glycine betaine
IG197_RS22300	COG3448	diguanylate cyclase activity
IG197_RS22320	COG5507	3-demethylubiquinone-9 3-methyltransferase
IG197_RS22325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IG197_RS22350	COG1278	Cold shock
IG197_RS22375	COG0714	Associated with various cellular activities
IG197_RS22385	COG0494	nUDIX hydrolase
IG197_RS22390	COG0617	tRNA 3'-terminal CCA addition
IG197_RS22410	COG0408	coproporphyrinogen oxidase activity
IG197_RS22440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IG197_RS22450	COG1132	(ABC) transporter
IG197_RS22455	COG1132	(ABC) transporter
IG197_RS22460	COG1132	(ABC) transporter
IG197_RS22465	COG0456	acetyltransferase
IG197_RS22465	COG0454	-acetyltransferase
IG197_RS22485	COG2857	Cytochrome c1
IG197_RS22485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IG197_RS22490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IG197_RS22520	COG0012	GTP binding
IG197_RS22525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IG197_RS22530	COG0193	aminoacyl-tRNA hydrolase activity
IG197_RS22535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IG197_RS22555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IG197_RS22570	COG1496	oxidoreductase activity
IG197_RS22580	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IG197_RS22595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IG197_RS22605	COG1464	Belongs to the NlpA lipoprotein family
IG197_RS22610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IG197_RS22615	COG2011	ABC-type metal ion transport system permease component
IG197_RS22620	COG2205	protein histidine kinase activity
IG197_RS22630	COG0745	RESPONSE REGULATOR receiver
IG197_RS22635	COG1846	Transcriptional regulator
IG197_RS22640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IG197_RS22650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG197_RS22660	COG1278	Cold shock
IG197_RS22670	COG1278	Cold shock
IG197_RS22685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG197_RS22695	COG0583	DNA-binding transcription factor activity
IG197_RS22705	COG1819	glycosyl
IG197_RS22710	COG1309	transcriptional regulator
IG197_RS22715	COG1794	racemase activity, acting on amino acids and derivatives
IG197_RS22725	COG3791	Glutathione-dependent formaldehyde-activating
IG197_RS22735	COG0726	polysaccharide deacetylase
IG197_RS22755	COG1396	sequence-specific DNA binding
IG197_RS22785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG197_RS22795	COG1522	sequence-specific DNA binding
IG197_RS22810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG197_RS22830	COG0583	DNA-binding transcription factor activity
IG197_RS22840	COG0556	nucleotide-excision repair
IG197_RS22850	COG0438	transferase activity, transferring glycosyl groups
IG197_RS22880	COG1597	lipid kinase activity
IG197_RS22890	COG2084	Dehydrogenase
IG197_RS22895	COG4948	Mandelate Racemase Muconate Lactonizing
IG197_RS22920	COG1253	flavin adenine dinucleotide binding
IG197_RS22965	COG0583	DNA-binding transcription factor activity
IG197_RS22975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IG197_RS22985	COG2133	pyrroloquinoline quinone binding
IG197_RS22990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG197_RS23005	COG3306	glycosyltransferase involved in LPS biosynthesis
IG197_RS23010	COG3306	glycosyltransferase involved in LPS biosynthesis
IG197_RS23020	COG1522	sequence-specific DNA binding
IG197_RS23025	COG0492	ferredoxin-NADP+ reductase activity
IG197_RS23030	COG0583	DNA-binding transcription factor activity
IG197_RS23035	COG0640	Transcriptional regulator
IG197_RS23060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IG197_RS23065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IG197_RS23080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG197_RS23090	COG0477	Major facilitator Superfamily
IG197_RS23130	COG0436	Aminotransferase
IG197_RS23150	COG1278	Cold shock
IG197_RS23160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IG197_RS23185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IG197_RS23195	COG2130	NADP-dependent
IG197_RS23205	COG3591	Belongs to the peptidase S1B family
IG197_RS23205	COG1864	DNA RNA non-specific endonuclease
IG197_RS23220	COG2814	Major facilitator Superfamily
IG197_RS23230	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS23240	COG2321	neutral zinc metallopeptidase
IG197_RS23245	COG4989	oxidoreductase activity
IG197_RS23280	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS23280	COG0596	Alpha beta hydrolase
IG197_RS23285	COG0505	Belongs to the CarA family
IG197_RS23300	COG1473	amidohydrolase
IG197_RS23310	COG0358	DNA primase activity
IG197_RS23315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IG197_RS23335	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IG197_RS23350	COG0372	Belongs to the citrate synthase family
IG197_RS23355	COG0372	Belongs to the citrate synthase family
IG197_RS23395	COG1280	lysine exporter protein (LysE YggA)
IG197_RS23440	COG0488	(ABC) transporter
IG197_RS23455	COG1522	sequence-specific DNA binding
IG197_RS23465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG197_RS23470	COG0583	DNA-binding transcription factor activity
IG197_RS23475	COG1309	transcriptional regulator
IG197_RS23495	COG2862	Uncharacterized protein family, UPF0114
IG197_RS23505	COG2983	Belongs to the UPF0260 family
IG197_RS23515	COG2968	Membrane
IG197_RS23530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IG197_RS23600	COG2948	multi-organism process
IG197_RS23615	COG3846	protein secretion by the type IV secretion system
IG197_RS23630	COG3451	type IV secretory pathway VirB4
IG197_RS23640	COG3838	Conjugal transfer protein Trbc
IG197_RS23645	COG4962	Type ii secretion system protein e
IG197_RS23670	COG3436	PFAM IS66 Orf2 family protein
IG197_RS23675	COG2433	Pfam Transposase IS66
IG197_RS23680	COG0741	lytic transglycosylase activity
IG197_RS23720	COG3608	succinylglutamate desuccinylase aspartoacylase
IG197_RS23725	COG1126	abc transporter atp-binding protein
IG197_RS23730	COG0765	amino acid transport
IG197_RS23735	COG0765	amino acid transport
IG197_RS23740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS23755	COG4957	zinc ion binding
IG197_RS23760	COG1216	Glycosyl transferase, family 2
IG197_RS23760	COG0463	Glycosyl transferase, family 2
IG197_RS23770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG197_RS23785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IG197_RS23790	COG0210	DNA helicase
IG197_RS23810	COG1476	TRANSCRIPTIONal
IG197_RS23815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IG197_RS23825	COG2197	response regulator
IG197_RS23830	COG3916	Acyl-homoserine-lactone synthase
IG197_RS23860	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS23860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS23870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS23880	COG0069	glutamate synthase activity
IG197_RS23885	COG2218	PFAM glutamate synthase alpha subunit domain protein
IG197_RS23890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IG197_RS23910	COG0154	amidase activity
IG197_RS23950	COG2186	Transcriptional regulator
IG197_RS23955	COG4266	Belongs to the allantoicase family
IG197_RS23975	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS23985	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IG197_RS23990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG197_RS24000	COG0830	nickel cation binding
IG197_RS24005	COG0831	urea catabolic process
IG197_RS24005	COG0832	Belongs to the urease beta subunit family
IG197_RS24010	COG0804	urea catabolic process
IG197_RS24015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IG197_RS24020	COG0829	nickel cation binding
IG197_RS24045	COG2132	Multicopper oxidase
IG197_RS24090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IG197_RS24110	COG2814	Major facilitator Superfamily
IG197_RS24120	COG4608	Belongs to the ABC transporter superfamily
IG197_RS24125	COG0444	Belongs to the ABC transporter superfamily
IG197_RS24130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS24135	COG0601	transmembrane transport
IG197_RS24140	COG0747	negative chemotaxis
IG197_RS24155	COG1473	amidohydrolase
IG197_RS24160	COG1473	amidohydrolase
IG197_RS24165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS24170	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS24180	COG5383	Protein conserved in bacteria
IG197_RS24190	COG1737	Transcriptional regulator
IG197_RS24190	COG0837	glucose binding
IG197_RS24200	COG0601	transmembrane transport
IG197_RS24205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS24210	COG0444	Belongs to the ABC transporter superfamily
IG197_RS24250	COG0463	Glycosyl transferase, family 2
IG197_RS24310	COG0367	asparagine synthase
IG197_RS24320	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS24325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IG197_RS24360	COG1902	pentaerythritol trinitrate reductase activity
IG197_RS24380	COG0673	inositol 2-dehydrogenase activity
IG197_RS24395	COG0589	response to stress
IG197_RS24400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS24405	COG4597	amino acid ABC transporter
IG197_RS24410	COG0765	amino acid transport
IG197_RS24425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IG197_RS24430	COG4208	sulfate ABC transporter
IG197_RS24435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IG197_RS24440	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IG197_RS24450	COG4953	penicillin-binding protein 1C
IG197_RS24460	COG0729	surface antigen
IG197_RS24470	COG4166	transmembrane transport
IG197_RS24475	COG0601	transmembrane transport
IG197_RS24480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS24490	COG0493	'glutamate synthase
IG197_RS24515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IG197_RS24530	COG1309	transcriptional regulator
IG197_RS24535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG197_RS24570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS24575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS24600	COG0028	Belongs to the TPP enzyme family
IG197_RS24605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG197_RS24610	COG2267	carboxylic ester hydrolase activity
IG197_RS24615	COG1131	(ABC) transporter
IG197_RS24620	COG0842	Transport permease protein
IG197_RS24645	COG4106	trans-aconitate 2-methyltransferase activity
IG197_RS24660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IG197_RS24665	COG1522	sequence-specific DNA binding
IG197_RS24675	COG1720	tRNA m6t6A37 methyltransferase activity
IG197_RS24700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IG197_RS24735	COG0697	spore germination
IG197_RS24740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IG197_RS24760	COG0626	cystathionine gamma-synthase activity
IG197_RS24765	COG2001	Belongs to the MraZ family
IG197_RS24770	COG0275	rRNA processing
IG197_RS24785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IG197_RS24795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IG197_RS24800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IG197_RS24810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IG197_RS24815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IG197_RS24820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IG197_RS24825	COG1181	Belongs to the D-alanine--D-alanine ligase family
IG197_RS24830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IG197_RS24835	COG0849	cell division
IG197_RS24840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IG197_RS24850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IG197_RS24880	COG0006	proline dipeptidase activity
IG197_RS24885	COG2264	protein methyltransferase activity
IG197_RS24890	COG1999	signal sequence binding
IG197_RS24925	COG5002	protein histidine kinase activity
IG197_RS24930	COG0745	RESPONSE REGULATOR receiver
IG197_RS24945	COG0210	DNA helicase
IG197_RS24970	COG0277	FAD linked oxidase domain protein
IG197_RS25015	COG2814	Major facilitator Superfamily
IG197_RS25020	COG3706	GGDEF domain
IG197_RS25045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IG197_RS25060	COG0330	HflC and HflK could
IG197_RS25065	COG0330	HflC and HflK could
IG197_RS25075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IG197_RS25085	COG3830	Belongs to the UPF0237 family
IG197_RS25085	COG0560	Phosphoserine phosphatase
IG197_RS25090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IG197_RS25100	COG2267	carboxylic ester hydrolase activity
IG197_RS25110	COG1132	(ABC) transporter
IG197_RS25115	COG0028	Belongs to the TPP enzyme family
IG197_RS25120	COG0440	acetolactate synthase activity
IG197_RS25170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IG197_RS25190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IG197_RS25195	COG3158	transport of potassium into the cell
IG197_RS25200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IG197_RS25220	COG0583	DNA-binding transcription factor activity
IG197_RS25225	COG1309	transcriptional regulator
IG197_RS25230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IG197_RS25260	COG0577	efflux transmembrane transporter activity
IG197_RS25260	COG1136	(ABC) transporter
IG197_RS25265	COG1136	(ABC) transporter
IG197_RS25265	COG0577	efflux transmembrane transporter activity
IG197_RS25275	COG0384	phenazine biosynthesis protein PhzF
IG197_RS25295	COG0628	permease
IG197_RS25315	COG1959	2 iron, 2 sulfur cluster binding
IG197_RS25320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IG197_RS25325	COG4208	sulfate ABC transporter
IG197_RS25335	COG4150	thiosulfate binding
IG197_RS25340	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IG197_RS25345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IG197_RS25350	COG1797	cobyrinic acid a,c-diamide synthase activity
IG197_RS25355	COG1648	precorrin-2 dehydrogenase activity
IG197_RS25355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IG197_RS25360	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IG197_RS25420	COG3214	Protein conserved in bacteria
IG197_RS25425	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG197_RS25430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG197_RS25435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG197_RS25440	COG0649	NAD binding
IG197_RS25445	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IG197_RS25450	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IG197_RS25455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IG197_RS25455	COG3743	rRNA binding
IG197_RS25465	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IG197_RS25470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IG197_RS25480	COG0713	ATP synthesis coupled electron transport
IG197_RS25495	COG1007	ATP synthesis coupled electron transport
IG197_RS25510	COG0346	lactoylglutathione lyase activity
IG197_RS25520	COG0442	prolyl-tRNA aminoacylation
IG197_RS25530	COG1136	(ABC) transporter
IG197_RS25535	COG0442	prolyl-tRNA aminoacylation
IG197_RS25545	COG0321	lipoyl(octanoyl) transferase activity
IG197_RS25570	COG0789	Transcriptional regulator
IG197_RS25575	COG2239	Acts as a magnesium transporter
IG197_RS25655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG197_RS25685	COG0583	DNA-binding transcription factor activity
IG197_RS25705	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS25705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS25715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS25720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IG197_RS25720	COG3264	Mechanosensitive ion channel
IG197_RS25745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG197_RS25810	COG0583	DNA-binding transcription factor activity
IG197_RS25835	COG0646	methionine synthase
IG197_RS25835	COG1410	methionine synthase
IG197_RS25855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IG197_RS25860	COG3932	Exopolysaccharide synthesis, ExoD
IG197_RS25880	COG5012	cobalamin binding
IG197_RS25885	COG5598	trimethylamine methyltransferase
IG197_RS25895	COG2186	Transcriptional regulator
IG197_RS25900	COG2807	transmembrane transport
IG197_RS25910	COG2081	HI0933 family
IG197_RS25925	COG2304	oxidoreductase activity
IG197_RS25945	COG0646	methionine synthase
IG197_RS25945	COG1410	methionine synthase
IG197_RS25975	COG0006	proline dipeptidase activity
IG197_RS25985	COG5598	trimethylamine methyltransferase
IG197_RS26020	COG1960	acyl-CoA dehydrogenase activity
IG197_RS26030	COG1492	cobalamin metabolic process
IG197_RS26055	COG4172	Belongs to the ABC transporter superfamily
IG197_RS26060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS26065	COG0601	transmembrane transport
IG197_RS26070	COG0747	negative chemotaxis
IG197_RS26075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG197_RS26100	COG0243	molybdopterin cofactor binding
IG197_RS26105	COG0437	4 iron, 4 sulfur cluster binding
IG197_RS26110	COG3302	dmso reductase anchor subunit
IG197_RS26115	COG1560	Kdo2-lipid A biosynthetic process
IG197_RS26125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IG197_RS26135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IG197_RS26165	COG1522	sequence-specific DNA binding
IG197_RS26195	COG1629	transport
IG197_RS26205	COG3720	iron ion transport
IG197_RS26215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG197_RS26220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IG197_RS26225	COG1959	2 iron, 2 sulfur cluster binding
IG197_RS26235	COG2733	membrane
IG197_RS26285	COG2832	Protein of unknown function (DUF454)
IG197_RS26290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IG197_RS26295	COG2205	protein histidine kinase activity
IG197_RS26340	COG2205	protein histidine kinase activity
IG197_RS26345	COG1525	nuclease
IG197_RS26350	COG0625	glutathione transferase activity
IG197_RS26355	COG1573	uracil-dna glycosylase
IG197_RS26360	COG1522	sequence-specific DNA binding
IG197_RS26370	COG2084	Dehydrogenase
IG197_RS26390	COG1763	Mo-molybdopterin cofactor biosynthetic process
IG197_RS26395	COG0746	molybdenum cofactor guanylyltransferase activity
IG197_RS26415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IG197_RS26435	COG1846	Transcriptional regulator
IG197_RS26440	COG0596	Alpha beta hydrolase
IG197_RS26460	COG2989	Protein conserved in bacteria
IG197_RS26480	COG0546	phosphoglycolate phosphatase activity
IG197_RS26485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IG197_RS26500	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IG197_RS26505	COG2199	diguanylate cyclase activity
IG197_RS26510	COG2514	catechol 2,3-dioxygenase activity
IG197_RS26525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IG197_RS26550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG197_RS26570	COG3608	succinylglutamate desuccinylase aspartoacylase
IG197_RS26570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IG197_RS26575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IG197_RS26610	COG0596	Alpha beta hydrolase
IG197_RS26610	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS26645	COG0583	DNA-binding transcription factor activity
IG197_RS26650	COG2855	membrane
IG197_RS26680	COG0850	regulation of cytokinetic process
IG197_RS26685	COG2894	cell division
IG197_RS26690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IG197_RS26700	COG2267	carboxylic ester hydrolase activity
IG197_RS26735	COG1607	acyl-coa hydrolase
IG197_RS26740	COG0251	oxidation-reduction process
IG197_RS26760	COG0071	Belongs to the small heat shock protein (HSP20) family
IG197_RS26810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IG197_RS26810	COG0045	succinate-CoA ligase (ADP-forming) activity
IG197_RS26810	COG1042	CoA-binding domain protein
IG197_RS26820	COG0459	protein refolding
IG197_RS26835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IG197_RS26840	COG2235	arginine
IG197_RS26870	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG197_RS26905	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IG197_RS26940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG197_RS26975	COG2205	protein histidine kinase activity
IG197_RS26980	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS27005	COG0586	Pfam SNARE associated Golgi protein
IG197_RS27020	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IG197_RS27030	COG1136	(ABC) transporter
IG197_RS27045	COG5622	Protein required for attachment to host cells
IG197_RS27050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IG197_RS27060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IG197_RS27070	COG1546	Belongs to the CinA family
IG197_RS27070	COG1058	Belongs to the CinA family
IG197_RS27080	COG0596	Alpha beta hydrolase
IG197_RS27105	COG2267	carboxylic ester hydrolase activity
IG197_RS27130	COG4191	Histidine kinase
IG197_RS27135	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IG197_RS27145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IG197_RS27150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG197_RS27165	COG1278	Cold shock
IG197_RS27185	COG1024	Enoyl-CoA hydratase
IG197_RS27230	COG0516	GMP reductase activity
IG197_RS27230	COG0517	IMP dehydrogenase activity
IG197_RS27235	COG3811	Belongs to the UPF0386 family
IG197_RS27245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IG197_RS27255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IG197_RS27260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IG197_RS27285	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IG197_RS27290	COG0439	Biotin carboxylase
IG197_RS27295	COG0511	ligase activity, forming carbon-carbon bonds
IG197_RS27300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IG197_RS27315	COG0436	Aminotransferase
IG197_RS27340	COG2066	Belongs to the glutaminase family
IG197_RS27360	COG4974	Belongs to the 'phage' integrase family
IG197_RS27465	COG2963	transposase activity
IG197_RS27470	COG3436	PFAM IS66 Orf2 family protein
IG197_RS27475	COG4372	Transposase
IG197_RS27810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG197_RS27825	COG0525	valine-tRNA ligase activity
IG197_RS27840	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IG197_RS27845	COG0708	Exodeoxyribonuclease III
IG197_RS27855	COG2233	PERMEase
IG197_RS27875	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IG197_RS27880	COG0018	arginyl-trna synthetase
IG197_RS27895	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IG197_RS27900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IG197_RS27905	COG3842	ATPase activity
IG197_RS27910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG197_RS27915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IG197_RS27920	COG0805	protein transport
IG197_RS27925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IG197_RS27930	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IG197_RS27935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IG197_RS27965	COG1120	ATPase activity
IG197_RS27970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IG197_RS27995	COG3483	tryptophan 2,3-dioxygenase activity
IG197_RS28015	COG0411	ABC transporter
IG197_RS28035	COG4120	Belongs to the binding-protein-dependent transport system permease family
IG197_RS28050	COG1802	Transcriptional regulator
IG197_RS28055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG197_RS28070	COG1335	isochorismatase
IG197_RS28085	COG1024	Enoyl-CoA hydratase
IG197_RS28090	COG1960	acyl-CoA dehydrogenase activity
IG197_RS28105	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG197_RS28105	COG1024	Enoyl-CoA hydratase
IG197_RS28110	COG0183	Belongs to the thiolase family
IG197_RS28115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IG197_RS28125	COG0165	Argininosuccinate lyase
IG197_RS28130	COG0395	ABC-type sugar transport system, permease component
IG197_RS28135	COG1175	transmembrane transport
IG197_RS28140	COG2182	Extracellular solute-binding protein
IG197_RS28145	COG1940	carbohydrate kinase activity
IG197_RS28170	COG3395	kinase activity
IG197_RS28175	COG4608	Belongs to the ABC transporter superfamily
IG197_RS28180	COG0444	Belongs to the ABC transporter superfamily
IG197_RS28185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS28195	COG0747	negative chemotaxis
IG197_RS28200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IG197_RS28205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IG197_RS28215	COG1454	alcohol dehydrogenase
IG197_RS28220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG197_RS28220	COG3453	Protein conserved in bacteria
IG197_RS28230	COG1522	sequence-specific DNA binding
IG197_RS28235	COG0406	alpha-ribazole phosphatase activity
IG197_RS28240	COG3842	ATPase activity
IG197_RS28245	COG4149	molybdate abc transporter
IG197_RS28260	COG4191	Histidine kinase
IG197_RS28265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IG197_RS28270	COG1802	Transcriptional regulator
IG197_RS28275	COG3938	Belongs to the proline racemase family
IG197_RS28280	COG1476	TRANSCRIPTIONal
IG197_RS28285	COG0747	negative chemotaxis
IG197_RS28290	COG0601	transmembrane transport
IG197_RS28295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS28300	COG0444	Belongs to the ABC transporter superfamily
IG197_RS28305	COG4608	Belongs to the ABC transporter superfamily
IG197_RS28310	COG0006	proline dipeptidase activity
IG197_RS28315	COG1879	ABC-type sugar transport system periplasmic component
IG197_RS28320	COG1129	ABC transporter
IG197_RS28325	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS28330	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS28345	COG0251	oxidation-reduction process
IG197_RS28350	COG3608	succinylglutamate desuccinylase aspartoacylase
IG197_RS28375	COG1846	Transcriptional regulator
IG197_RS28395	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG197_RS28400	COG3971	2-oxopent-4-enoate hydratase activity
IG197_RS28410	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS28420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS28425	COG0601	transmembrane transport
IG197_RS28435	COG2186	Transcriptional regulator
IG197_RS28465	COG2159	amidohydrolase
IG197_RS28470	COG3384	dioxygenase
IG197_RS28480	COG0473	3-isopropylmalate dehydrogenase activity
IG197_RS28480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG197_RS28485	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG197_RS28495	COG1448	Aminotransferase
IG197_RS28500	COG0028	Belongs to the TPP enzyme family
IG197_RS28535	COG1022	Amp-dependent synthetase and ligase
IG197_RS28585	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IG197_RS28590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS28600	COG0523	cobalamin synthesis protein
IG197_RS28615	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS28625	COG1942	4-Oxalocrotonate Tautomerase
IG197_RS28640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IG197_RS28655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG197_RS28665	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS28675	COG4948	Mandelate Racemase Muconate Lactonizing
IG197_RS28685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG197_RS28690	COG4521	taurine ABC transporter
IG197_RS28695	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IG197_RS28700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS28715	COG0028	Belongs to the TPP enzyme family
IG197_RS28720	COG2855	membrane
IG197_RS28740	COG0829	nickel cation binding
IG197_RS28745	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IG197_RS28750	COG0804	urea catabolic process
IG197_RS28755	COG0831	urea catabolic process
IG197_RS28755	COG0832	Belongs to the urease beta subunit family
IG197_RS28760	COG0830	nickel cation binding
IG197_RS28770	COG1126	abc transporter atp-binding protein
IG197_RS28805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG197_RS28840	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG197_RS28850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG197_RS28855	COG0720	synthase
IG197_RS28865	COG5001	Diguanylate cyclase
IG197_RS28880	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IG197_RS28895	COG1921	L-seryl-tRNASec selenium transferase activity
IG197_RS28910	COG3964	amidohydrolase
IG197_RS28920	COG0601	transmembrane transport
IG197_RS28925	COG0747	negative chemotaxis
IG197_RS28940	COG1177	transmembrane transport
IG197_RS28955	COG1840	ABC-type Fe3 transport system, periplasmic component
IG197_RS28960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IG197_RS28970	COG0583	DNA-binding transcription factor activity
IG197_RS28975	COG1129	ABC transporter
IG197_RS28985	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS29000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG197_RS29005	COG1940	carbohydrate kinase activity
IG197_RS29020	COG4175	Glycine betaine
IG197_RS29020	COG0517	IMP dehydrogenase activity
IG197_RS29025	COG4176	ABC-type proline glycine betaine transport system permease component
IG197_RS29035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IG197_RS29055	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS29060	COG0583	DNA-binding transcription factor activity
IG197_RS29070	COG3806	Anti-sigma factor
IG197_RS29075	COG1595	DNA-templated transcription, initiation
IG197_RS29090	COG0300	oxidoreductase activity
IG197_RS29120	COG2188	Transcriptional regulator
IG197_RS29130	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IG197_RS29130	COG1940	carbohydrate kinase activity
IG197_RS29140	COG1175	transmembrane transport
IG197_RS29145	COG0395	ABC-type sugar transport system, permease component
IG197_RS29155	COG0235	Class ii aldolase
IG197_RS29160	COG3254	rhamnose metabolic process
IG197_RS29165	COG4952	isomerase
IG197_RS29175	COG1070	Carbohydrate kinase
IG197_RS29190	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS29195	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS29200	COG1129	ABC transporter
IG197_RS29215	COG3347	Dehydrogenase
IG197_RS29215	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS29230	COG0500	methyltransferase
IG197_RS29240	COG1414	Transcriptional regulator
IG197_RS29245	COG1475	DNA binding
IG197_RS29250	COG1192	Involved in chromosome partitioning
IG197_RS29255	COG3831	ATPase activity
IG197_RS29265	COG0277	FAD linked oxidase domain protein
IG197_RS29275	COG0604	alcohol dehydrogenase
IG197_RS29280	COG1024	Enoyl-CoA hydratase
IG197_RS29285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IG197_RS29300	COG3842	ATPase activity
IG197_RS29305	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS29310	COG4208	sulfate ABC transporter
IG197_RS29320	COG0765	amino acid transport
IG197_RS29385	COG1674	ftsk spoiiie
IG197_RS29390	COG5001	Diguanylate cyclase
IG197_RS29440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IG197_RS29445	COG2826	transposase and inactivated derivatives, IS30 family
IG197_RS29465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IG197_RS29470	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IG197_RS29475	COG3842	ATPase activity
IG197_RS29500	COG2390	Transcriptional regulator
IG197_RS29510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IG197_RS29520	COG3732	PTS system glucitol sorbitol-specific
IG197_RS29540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IG197_RS29550	COG1177	transmembrane transport
IG197_RS29560	COG3842	ATPase activity
IG197_RS29575	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS29580	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS29580	COG0022	dehydrogenase e1 component
IG197_RS29585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IG197_RS29595	COG3608	succinylglutamate desuccinylase aspartoacylase
IG197_RS29600	COG1126	abc transporter atp-binding protein
IG197_RS29605	COG0765	amino acid transport
IG197_RS29610	COG0765	amino acid transport
IG197_RS29615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS29635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IG197_RS29755	COG0739	heme binding
IG197_RS29755	COG0741	lytic transglycosylase activity
IG197_RS29755	COG1196	nuclear chromosome segregation
IG197_RS29765	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS29775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IG197_RS29795	COG1013	pyruvate-flavodoxin oxidoreductase activity
IG197_RS29815	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS29845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IG197_RS29850	COG4608	Belongs to the ABC transporter superfamily
IG197_RS29855	COG0444	Belongs to the ABC transporter superfamily
IG197_RS29870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS29875	COG0667	Aldo Keto reductase
IG197_RS29880	COG0747	negative chemotaxis
IG197_RS29885	COG1414	Transcriptional regulator
IG197_RS29900	COG1349	DNA-binding transcription factor activity
IG197_RS29930	COG3795	YCII-related domain
IG197_RS29950	COG0583	DNA-binding transcription factor activity
IG197_RS29960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IG197_RS29970	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS29995	COG3842	ATPase activity
IG197_RS30005	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS30025	COG1840	ABC-type Fe3 transport system, periplasmic component
IG197_RS30030	COG3842	ATPase activity
IG197_RS30040	COG0625	glutathione transferase activity
IG197_RS30050	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IG197_RS30060	COG1522	sequence-specific DNA binding
IG197_RS30075	COG1216	Glycosyl transferase, family 2
IG197_RS30075	COG0463	Glycosyl transferase, family 2
IG197_RS30085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IG197_RS30115	COG0531	amino acid
IG197_RS30170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG197_RS30175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IG197_RS30190	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS30190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS30200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS30210	COG0069	glutamate synthase activity
IG197_RS30215	COG2218	PFAM glutamate synthase alpha subunit domain protein
IG197_RS30220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IG197_RS30250	COG2379	hydroxypyruvate reductase
IG197_RS30255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG197_RS30260	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IG197_RS30265	COG0045	succinate-CoA ligase (ADP-forming) activity
IG197_RS30285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS30290	COG1957	nucleoside hydrolase
IG197_RS30300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IG197_RS30365	COG1271	oxidase subunit
IG197_RS30370	COG1294	oxidase, subunit
IG197_RS30385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IG197_RS30390	COG2986	histidine ammonia-lyase
IG197_RS30395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IG197_RS30405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IG197_RS30425	COG3831	ATPase activity
IG197_RS30430	COG4227	nucleotidyltransferase activity
IG197_RS30435	COG5489	Protein of unknown function (DUF736)
IG197_RS30455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IG197_RS30480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IG197_RS30485	COG4959	Type IV secretory pathway protease TraF
IG197_RS30505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IG197_RS30575	COG3701	Conjugal transfer protein
IG197_RS30580	COG3846	protein secretion by the type IV secretion system
IG197_RS30590	COG5314	conjugation
IG197_RS30595	COG3451	type IV secretory pathway VirB4
IG197_RS30600	COG5268	conjugation
IG197_RS30605	COG3838	Conjugal transfer protein Trbc
IG197_RS30610	COG4962	Type ii secretion system protein e
IG197_RS30615	COG3916	Acyl-homoserine-lactone synthase
IG197_RS30625	COG3177	Filamentation induced by cAMP protein fic
IG197_RS30635	COG1192	Involved in chromosome partitioning
IG197_RS30640	COG1475	DNA binding
IG197_RS30645	COG0640	Transcriptional regulator
IG197_RS30655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG197_RS30685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG197_RS30715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IG197_RS30755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IG197_RS30765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IG197_RS30770	COG3842	ATPase activity
IG197_RS30775	COG1653	transport
IG197_RS30780	COG1175	transmembrane transport
IG197_RS30785	COG0395	ABC-type sugar transport system, permease component
IG197_RS30805	COG0277	FAD linked oxidase domain protein
IG197_RS30810	COG0625	glutathione transferase activity
IG197_RS30815	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS30820	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS30830	COG1454	alcohol dehydrogenase
IG197_RS30840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IG197_RS30845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IG197_RS30950	COG1475	DNA binding
IG197_RS30960	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS30960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS30970	COG4638	Rieske (2fe-2S)
IG197_RS31005	COG0583	DNA-binding transcription factor activity
IG197_RS31010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS31015	COG0765	amino acid transport
IG197_RS31020	COG1126	abc transporter atp-binding protein
IG197_RS31035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IG197_RS31040	COG0626	cystathionine gamma-synthase activity
IG197_RS31050	COG4372	Transposase
IG197_RS31055	COG3436	PFAM IS66 Orf2 family protein
IG197_RS31060	COG2963	transposase activity
IG197_RS31100	COG5001	Diguanylate cyclase
IG197_RS31110	COG4957	zinc ion binding
IG197_RS31115	COG2199	diguanylate cyclase activity
IG197_RS31140	COG0459	protein refolding
IG197_RS31170	COG1802	Transcriptional regulator
IG197_RS31175	COG0747	negative chemotaxis
IG197_RS31180	COG0601	transmembrane transport
IG197_RS31185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS31190	COG4172	Belongs to the ABC transporter superfamily
IG197_RS31195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IG197_RS31200	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS31215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS31225	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IG197_RS31260	COG0831	urea catabolic process
IG197_RS31260	COG0832	Belongs to the urease beta subunit family
IG197_RS31265	COG0804	urea catabolic process
IG197_RS31270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IG197_RS31275	COG0829	nickel cation binding
IG197_RS31285	COG0830	nickel cation binding
IG197_RS31315	COG1484	DNA-dependent DNA replication
IG197_RS31325	COG1396	sequence-specific DNA binding
IG197_RS31325	COG3800	Transcriptional regulator
IG197_RS31335	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IG197_RS31340	COG3791	Glutathione-dependent formaldehyde-activating
IG197_RS31385	COG3831	ATPase activity
IG197_RS31390	COG3505	Type IV secretory pathway VirD4
IG197_RS31405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IG197_RS31410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IG197_RS31430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS31435	COG0765	amino acid transport
IG197_RS31440	COG0765	amino acid transport
IG197_RS31445	COG1126	abc transporter atp-binding protein
IG197_RS31450	COG3608	succinylglutamate desuccinylase aspartoacylase
IG197_RS31455	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS31470	COG3916	Acyl-homoserine-lactone synthase
IG197_RS31475	COG2197	response regulator
IG197_RS31485	COG5001	Diguanylate cyclase
IG197_RS31490	COG0602	queuosine metabolic process
IG197_RS31500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IG197_RS31515	COG2771	luxR family
IG197_RS31520	COG1192	Involved in chromosome partitioning
IG197_RS31525	COG1475	DNA binding
IG197_RS31530	COG1414	Transcriptional regulator
IG197_RS31560	COG0582	viral genome integration into host DNA
IG197_RS31565	COG4974	Belongs to the 'phage' integrase family
IG197_RS31580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IG197_RS31585	COG2086	electron transfer activity
IG197_RS31590	COG2301	Belongs to the HpcH HpaI aldolase family
IG197_RS31595	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IG197_RS31610	COG2079	MmgE PrpD family protein
IG197_RS31635	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS31640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IG197_RS31645	COG1024	Enoyl-CoA hydratase
IG197_RS31650	COG1250	3-hydroxyacyl-CoA dehydrogenase
IG197_RS31660	COG3246	L-lysine catabolic process to acetate
IG197_RS31675	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS31680	COG1177	transmembrane transport
IG197_RS31685	COG1960	acyl-CoA dehydrogenase activity
IG197_RS31695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG197_RS31700	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS31715	COG0745	RESPONSE REGULATOR receiver
IG197_RS31735	COG4977	sequence-specific DNA binding
IG197_RS31745	COG1473	amidohydrolase
IG197_RS31750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IG197_RS31755	COG1522	sequence-specific DNA binding
IG197_RS31770	COG0765	amino acid transport
IG197_RS31775	COG0765	amino acid transport
IG197_RS31780	COG1126	abc transporter atp-binding protein
IG197_RS31790	COG0006	proline dipeptidase activity
IG197_RS31800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS31805	COG4311	Sarcosine oxidase, delta subunit
IG197_RS31820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG197_RS31825	COG3344	reverse transcriptase
IG197_RS31835	COG4644	lycopene metabolic process
IG197_RS31840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG197_RS31845	COG1376	ErfK ybiS ycfS ynhG family protein
IG197_RS31860	COG2184	nucleotidyltransferase activity
IG197_RS32010	COG3328	transposase activity
IG197_RS32030	COG0590	tRNA wobble adenosine to inosine editing
IG197_RS32035	COG3328	transposase activity
IG197_RS32060	COG0519	Catalyzes the synthesis of GMP from XMP
IG197_RS32060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IG197_RS32150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG197_RS32220	COG0789	Transcriptional regulator
IG197_RS32240	COG3436	PFAM IS66 Orf2 family protein
IG197_RS32270	COG1141	Ferredoxin
IG197_RS32355	COG3831	ATPase activity
IG197_RS32370	COG5489	Protein of unknown function (DUF736)
IG197_RS32385	COG5489	Protein of unknown function (DUF736)
IG197_RS32425	COG1475	DNA binding
IG197_RS32485	COG0210	DNA helicase
IG197_RS32510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IG197_RS32560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IG197_RS32580	COG1959	2 iron, 2 sulfur cluster binding
IG197_RS32595	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IG197_RS32600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG197_RS32605	COG0640	Transcriptional regulator
IG197_RS32610	COG1475	DNA binding
IG197_RS32615	COG1192	Involved in chromosome partitioning
IG197_RS32625	COG4962	Type ii secretion system protein e
IG197_RS32645	COG5314	conjugation
IG197_RS32655	COG3846	protein secretion by the type IV secretion system
IG197_RS32660	COG3701	Conjugal transfer protein
IG197_RS32700	COG0251	oxidation-reduction process
IG197_RS32705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IG197_RS32710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IG197_RS32715	COG1522	sequence-specific DNA binding
IG197_RS32720	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IG197_RS32730	COG1012	belongs to the aldehyde dehydrogenase family
IG197_RS32750	COG1917	Cupin 2, conserved barrel domain protein
IG197_RS32760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IG197_RS32765	COG0840	transmembrane signaling receptor activity
IG197_RS32770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IG197_RS32810	COG3436	PFAM IS66 Orf2 family protein
IG197_RS32815	COG2433	Pfam Transposase IS66
IG197_RS32835	COG1141	Ferredoxin
IG197_RS32855	COG0492	ferredoxin-NADP+ reductase activity
IG197_RS32920	COG3831	ATPase activity
IG197_RS32930	COG5489	Protein of unknown function (DUF736)
IG197_RS33140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IG197_RS33150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IG197_RS33175	COG3093	addiction module antidote protein HigA
IG197_RS33240	COG3436	PFAM IS66 Orf2 family protein
IG197_RS33285	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG197_RS33295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG197_RS33335	COG0640	Transcriptional regulator
IG197_RS33345	COG2226	methyltransferase
IG197_RS33370	COG3177	Filamentation induced by cAMP protein fic
IG197_RS33375	COG3177	Filamentation induced by cAMP protein fic
IG197_RS33395	COG4521	taurine ABC transporter
IG197_RS33410	COG1845	cytochrome c oxidase, subunit III
IG197_RS33425	COG3256	nitric oxide reductase
IG197_RS33430	COG0714	Associated with various cellular activities
IG197_RS33445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IG197_RS33475	COG1959	2 iron, 2 sulfur cluster binding
IG197_RS33480	COG4459	periplasmic nitrate reductase
IG197_RS33505	COG3005	denitrification pathway
IG197_RS33540	COG3794	PFAM blue (type 1) copper domain protein
IG197_RS33600	COG2151	metal-sulfur cluster biosynthetic enzyme
IG197_RS33630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IG197_RS33635	COG0521	Mo-molybdopterin cofactor biosynthetic process
IG197_RS33645	COG0826	peptidase U32
IG197_RS33655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IG197_RS33665	COG2832	Protein of unknown function (DUF454)
IG197_RS33680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IG197_RS33720	COG2010	Cytochrome c
IG197_RS33735	COG3278	Belongs to the heme-copper respiratory oxidase family
IG197_RS33745	COG1959	2 iron, 2 sulfur cluster binding
IG197_RS33750	COG2826	transposase and inactivated derivatives, IS30 family
IG197_RS33755	COG2801	Transposase and inactivated derivatives
IG197_RS33810	COG3831	ATPase activity
IG197_RS33815	COG5489	Protein of unknown function (DUF736)
IG197_RS33845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IG197_RS33850	COG0508	dehydrogenase complex catalyzes the overall conversion of
IG197_RS33855	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IG197_RS33860	COG1522	sequence-specific DNA binding
IG197_RS33865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IG197_RS33880	COG1172	Belongs to the binding-protein-dependent transport system permease family
IG197_RS33885	COG1129	ABC transporter
IG197_RS33895	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG197_RS33915	COG4717	serine-type aminopeptidase activity
IG197_RS33920	COG0420	3'-5' exonuclease activity
IG197_RS33925	COG3550	peptidyl-serine autophosphorylation
IG197_RS33950	COG0583	DNA-binding transcription factor activity
IG197_RS33970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IG197_RS33980	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS33990	COG3845	ABC transporter
IG197_RS34010	COG1414	Transcriptional regulator
IG197_RS34035	COG0559	Belongs to the binding-protein-dependent transport system permease family
IG197_RS34040	COG0683	leucine binding
IG197_RS34055	COG0626	cystathionine gamma-synthase activity
IG197_RS34105	COG1228	amidohydrolase
IG197_RS34125	COG3842	ATPase activity
IG197_RS34130	COG1177	transmembrane transport
IG197_RS34135	COG1176	ABC-type spermidine putrescine transport system, permease component I
IG197_RS34145	COG0583	DNA-binding transcription factor activity
IG197_RS34155	COG1760	l-serine dehydratase
IG197_RS34160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IG197_RS34170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IG197_RS34170	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS34235	COG1414	Transcriptional regulator
IG197_RS34240	COG1475	DNA binding
IG197_RS34245	COG1192	Involved in chromosome partitioning
IG197_RS34255	COG4962	Type ii secretion system protein e
IG197_RS34260	COG3838	Conjugal transfer protein Trbc
IG197_RS34265	COG5268	conjugation
IG197_RS34270	COG3451	type IV secretory pathway VirB4
IG197_RS34275	COG5314	conjugation
IG197_RS34285	COG3846	protein secretion by the type IV secretion system
IG197_RS34290	COG3701	Conjugal transfer protein
IG197_RS34325	COG1295	ribonuclease BN
IG197_RS34340	COG0189	ligase activity
IG197_RS34355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IG197_RS34375	COG3916	Acyl-homoserine-lactone synthase
IG197_RS34405	COG0601	transmembrane transport
IG197_RS34410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IG197_RS34415	COG0444	Belongs to the ABC transporter superfamily
IG197_RS34430	COG0006	proline dipeptidase activity
IG197_RS34465	COG1136	(ABC) transporter
IG197_RS34505	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS34515	COG0154	amidase activity
IG197_RS34525	COG1902	pentaerythritol trinitrate reductase activity
IG197_RS34575	COG1960	acyl-CoA dehydrogenase activity
IG197_RS34580	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS34600	COG0747	negative chemotaxis
IG197_RS34610	COG0601	transmembrane transport
IG197_RS34615	COG0444	Belongs to the ABC transporter superfamily
IG197_RS34630	COG0179	Fumarylacetoacetate (FAA) hydrolase
IG197_RS34640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IG197_RS34675	COG2986	histidine ammonia-lyase
IG197_RS34680	COG3608	succinylglutamate desuccinylase aspartoacylase
IG197_RS34685	COG1126	abc transporter atp-binding protein
IG197_RS34690	COG0765	amino acid transport
IG197_RS34695	COG0765	amino acid transport
IG197_RS34700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IG197_RS34715	COG4957	zinc ion binding
IG197_RS34765	COG1959	2 iron, 2 sulfur cluster binding
IG197_RS34840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IG197_RS34885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IG197_RS34900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG197_RS34910	COG1028	Short-chain dehydrogenase reductase Sdr
IG197_RS34915	COG0318	PFAM AMP-dependent synthetase and ligase
IG197_RS34920	COG1454	alcohol dehydrogenase
IG197_RS34945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IG197_RS34970	COG0446	pyridine nucleotide-disulphide oxidoreductase
IG197_RS34970	COG1902	pentaerythritol trinitrate reductase activity
IG197_RS34975	COG4948	Mandelate Racemase Muconate Lactonizing
IG197_RS34980	COG5012	cobalamin binding
IG197_RS34985	COG0747	negative chemotaxis
IG197_RS34990	COG5598	trimethylamine methyltransferase
IG197_RS34995	COG0583	DNA-binding transcription factor activity
IG197_RS35000	COG3474	cytochrome
IG197_RS35020	COG3041	Addiction module toxin RelE StbE family
IG197_RS35025	COG3077	Addiction module antitoxin, RelB DinJ family
IG197_RS35040	COG3077	Addiction module antitoxin, RelB DinJ family
IG197_RS35055	COG3077	Addiction module antitoxin, RelB DinJ family
IG197_RS35190	COG0590	tRNA wobble adenosine to inosine editing
IG197_RS35225	COG2252	PERMEase
IG197_RS35250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IG197_RS35280	COG0789	Transcriptional regulator
IG197_RS35320	COG0789	Transcriptional regulator
IG197_RS35350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IG197_RS35355	COG1304	FMN binding
IG197_RS35365	COG0549	Belongs to the carbamate kinase family
IG197_RS35370	COG0402	S-adenosylhomocysteine deaminase activity
IG197_RS35375	COG1744	ABC transporter substrate-binding protein PnrA-like
IG197_RS35380	COG3845	ABC transporter
IG197_RS35385	COG4603	Belongs to the binding-protein-dependent transport system permease family
IG197_RS35390	COG1079	Belongs to the binding-protein-dependent transport system permease family
IG197_RS35465	COG3451	type IV secretory pathway VirB4
IG197_RS35470	COG5268	conjugation
IG197_RS35475	COG3838	Conjugal transfer protein Trbc
IG197_RS35480	COG4962	Type ii secretion system protein e
IG197_RS35500	COG0789	Transcriptional regulator
IG197_RS35505	COG2608	mercury ion transmembrane transporter activity
IG197_RS35510	COG2608	mercury ion transmembrane transporter activity
IG197_RS35520	COG0789	Transcriptional regulator
IG197_RS35575	COG0549	Belongs to the carbamate kinase family
IG197_RS35590	COG2233	PERMEase
IG197_RS35610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IG197_RS35630	COG1116	anion transmembrane transporter activity
IG197_RS35630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IG197_RS35635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IG197_RS35645	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IG197_RS35660	COG3547	Transposase (IS116 IS110 IS902 family)
IG197_RS35665	COG3039	Transposase
IG197_RS35695	COG3041	Addiction module toxin RelE StbE family
IG197_RS35700	COG3077	Addiction module antitoxin, RelB DinJ family
IG197_RS35715	COG3077	Addiction module antitoxin, RelB DinJ family
IG197_RS35725	COG3041	Addiction module toxin RelE StbE family
IG197_RS35730	COG3077	Addiction module antitoxin, RelB DinJ family
IG197_RS35835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IG197_RS35865	COG0590	tRNA wobble adenosine to inosine editing
IG197_RS35900	COG2252	PERMEase
IG197_RS35910	COG2252	PERMEase
IG197_RS35980	COG5268	conjugation
IG197_RS35990	COG4962	Type ii secretion system protein e
IG197_RS36015	COG2608	mercury ion transmembrane transporter activity