locus-tag	class	description
AMICO_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMICO_RS00010	COG0592	DNA-directed DNA polymerase activity
AMICO_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMICO_RS00035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AMICO_RS00040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMICO_RS00045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AMICO_RS00050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMICO_RS00055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMICO_RS00060	COG2171	N-acyltransferase activity
AMICO_RS00080	COG0489	protein tyrosine kinase activity
AMICO_RS00095	COG0735	belongs to the Fur family
AMICO_RS00110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AMICO_RS00130	COG1830	Aldolase
AMICO_RS00135	COG2084	Dehydrogenase
AMICO_RS00155	COG4176	ABC-type proline glycine betaine transport system permease component
AMICO_RS00180	COG0483	inositol monophosphate 1-phosphatase activity
AMICO_RS00185	COG1283	sodium-dependent phosphate transmembrane transporter activity
AMICO_RS00200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMICO_RS00205	COG0581	inorganic phosphate transmembrane transporter activity
AMICO_RS00210	COG0573	inorganic phosphate transmembrane transporter activity
AMICO_RS00225	COG0765	amino acid transport
AMICO_RS00230	COG1126	abc transporter atp-binding protein
AMICO_RS00265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMICO_RS00270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AMICO_RS00285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMICO_RS00290	COG2217	Heavy metal translocating P-type atpase
AMICO_RS00310	COG1122	ATPase activity
AMICO_RS00320	COG0310	cobalt ion transport
AMICO_RS00325	COG0310	cobalt ion transport
AMICO_RS00335	COG0384	phenazine biosynthesis protein PhzF
AMICO_RS00340	COG0765	amino acid transport
AMICO_RS00345	COG1126	abc transporter atp-binding protein
AMICO_RS00350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMICO_RS00360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMICO_RS00365	COG3901	Regulator of nitric oxide reductase transcription
AMICO_RS00365	COG0348	domain, Protein
AMICO_RS00375	COG1760	l-serine dehydratase
AMICO_RS00380	COG1760	l-serine dehydratase
AMICO_RS00390	COG0442	prolyl-tRNA aminoacylation
AMICO_RS00400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AMICO_RS00405	COG3924	membrane
AMICO_RS00410	COG4145	pantothenate transmembrane transporter activity
AMICO_RS00415	COG1414	Transcriptional regulator
AMICO_RS00420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMICO_RS00425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AMICO_RS00430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS00440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS00440	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS00445	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AMICO_RS00450	COG0778	Nitroreductase
AMICO_RS00455	COG0167	dihydroorotate dehydrogenase activity
AMICO_RS00465	COG1045	serine acetyltransferase
AMICO_RS00470	COG0473	3-isopropylmalate dehydrogenase activity
AMICO_RS00475	COG0066	3-isopropylmalate dehydratase activity
AMICO_RS00480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMICO_RS00485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMICO_RS00500	COG4656	Part of a membrane complex involved in electron transport
AMICO_RS00505	COG4658	electron transport chain
AMICO_RS00510	COG4659	FMN binding
AMICO_RS00515	COG4660	Part of a membrane complex involved in electron transport
AMICO_RS00520	COG4657	Part of a membrane complex involved in electron transport
AMICO_RS00525	COG2878	Part of a membrane complex involved in electron transport
AMICO_RS00525	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMICO_RS00540	COG1477	protein flavinylation
AMICO_RS00545	COG1115	amino acid carrier protein
AMICO_RS00550	COG1615	UPF0182 protein
AMICO_RS00565	COG3681	Belongs to the UPF0597 family
AMICO_RS00570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AMICO_RS00575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMICO_RS00605	COG1203	CRISPR-associated helicase, Cas3
AMICO_RS00625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS00645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AMICO_RS00655	COG0281	malic enzyme
AMICO_RS00700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMICO_RS00705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMICO_RS00720	COG0425	Belongs to the sulfur carrier protein TusA family
AMICO_RS00720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMICO_RS00735	COG4187	Peptidase family M20/M25/M40
AMICO_RS00750	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMICO_RS00780	COG1959	2 iron, 2 sulfur cluster binding
AMICO_RS00790	COG0822	iron-sulfur transferase activity
AMICO_RS00800	COG2818	Glycosylase
AMICO_RS00805	COG2414	aldehyde ferredoxin oxidoreductase
AMICO_RS00820	COG4953	penicillin-binding protein 1C
AMICO_RS00830	COG0542	response to heat
AMICO_RS00840	COG3290	protein histidine kinase activity
AMICO_RS00845	COG4565	transcriptional regulatory protein
AMICO_RS00885	COG1254	Belongs to the acylphosphatase family
AMICO_RS00895	COG1509	lysine 2,3-aminomutase activity
AMICO_RS00905	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMICO_RS00910	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMICO_RS00920	COG1659	Linocin_M18 bacteriocin protein
AMICO_RS00940	COG1164	Oligoendopeptidase f
AMICO_RS00945	COG0583	DNA-binding transcription factor activity
AMICO_RS00950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMICO_RS00955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMICO_RS00975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS00975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS00980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMICO_RS00995	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMICO_RS01000	COG3835	regulator
AMICO_RS01010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS01020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS01020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS01025	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMICO_RS01030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMICO_RS01050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMICO_RS01055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS01090	COG0745	RESPONSE REGULATOR receiver
AMICO_RS01095	COG3875	lactate racemase activity
AMICO_RS01100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMICO_RS01105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMICO_RS01110	COG0019	diaminopimelate decarboxylase activity
AMICO_RS01115	COG1757	Na H antiporter
AMICO_RS01120	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AMICO_RS01130	COG0297	glycogen (starch) synthase activity
AMICO_RS01135	COG0058	SHG alpha-glucan phosphorylase activity
AMICO_RS01140	COG1640	4-alpha-glucanotransferase
AMICO_RS01145	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMICO_RS01160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMICO_RS01165	COG1811	Na channel or pump
AMICO_RS01170	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMICO_RS01175	COG4603	Belongs to the binding-protein-dependent transport system permease family
AMICO_RS01180	COG3845	ABC transporter
AMICO_RS01190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AMICO_RS01205	COG0438	transferase activity, transferring glycosyl groups
AMICO_RS01210	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AMICO_RS01220	COG0778	Nitroreductase
AMICO_RS01220	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AMICO_RS01225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMICO_RS01230	COG0688	phosphatidylethanolamine metabolic process
AMICO_RS01235	COG1183	phosphatidylcholine synthase activity
AMICO_RS01240	COG0352	thiamine-phosphate diphosphorylase activity
AMICO_RS01240	COG0351	phosphomethylpyrimidine kinase
AMICO_RS01245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AMICO_RS01250	COG0352	thiamine-phosphate diphosphorylase activity
AMICO_RS01260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMICO_RS01265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMICO_RS01270	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AMICO_RS01275	COG3859	Proton-coupled thiamine transporter YuaJ
AMICO_RS01295	COG0346	lactoylglutathione lyase activity
AMICO_RS01300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMICO_RS01310	COG4770	biotin carboxylase activity
AMICO_RS01315	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AMICO_RS01325	COG1489	DNA binding
AMICO_RS01345	COG0038	chloride channel
AMICO_RS01350	COG1301	dicarboxylic acid transport
AMICO_RS01360	COG0442	prolyl-tRNA aminoacylation
AMICO_RS01365	COG0248	Ppx GppA phosphatase
AMICO_RS01365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMICO_RS01370	COG1283	sodium-dependent phosphate transmembrane transporter activity
AMICO_RS01375	COG0704	Plays a role in the regulation of phosphate uptake
AMICO_RS01380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMICO_RS01415	COG0460	homoserine dehydrogenase
AMICO_RS01425	COG0613	PHP domain protein
AMICO_RS01430	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AMICO_RS01440	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMICO_RS01450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMICO_RS01455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMICO_RS01470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMICO_RS01475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AMICO_RS01480	COG2239	Acts as a magnesium transporter
AMICO_RS01535	COG2197	response regulator
AMICO_RS01550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMICO_RS01555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMICO_RS01570	COG0250	Participates in transcription elongation, termination and antitermination
AMICO_RS01575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AMICO_RS01580	COG0081	regulation of translation
AMICO_RS01585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AMICO_RS01590	COG0222	ribosome binding
AMICO_RS01595	COG1515	deoxyribonuclease V activity
AMICO_RS01635	COG4895	conserved protein (DUF2196)
AMICO_RS01665	COG2962	Rard protein
AMICO_RS01680	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMICO_RS01690	COG4206	TonB-dependent receptor
AMICO_RS01700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMICO_RS01705	COG1120	ATPase activity
AMICO_RS01720	COG0811	peptide transport
AMICO_RS01725	COG0733	neurotransmitter:sodium symporter activity
AMICO_RS01730	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AMICO_RS01745	COG0837	glucose binding
AMICO_RS01760	COG0488	(ABC) transporter
AMICO_RS01765	COG2271	Major facilitator Superfamily
AMICO_RS01770	COG1278	Cold shock
AMICO_RS01780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMICO_RS01795	COG0697	spore germination
AMICO_RS01800	COG3835	regulator
AMICO_RS01805	COG1609	Transcriptional regulator
AMICO_RS01810	COG1129	ABC transporter
AMICO_RS01830	COG0778	Nitroreductase
AMICO_RS01830	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AMICO_RS01835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AMICO_RS01840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMICO_RS01850	COG1196	nuclear chromosome segregation
AMICO_RS01850	COG0741	lytic transglycosylase activity
AMICO_RS01850	COG0739	heme binding
AMICO_RS01855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMICO_RS01860	COG0436	Aminotransferase
AMICO_RS01865	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AMICO_RS01870	COG3481	metal-dependent phosphohydrolase, HD sub domain
AMICO_RS01875	COG0564	pseudouridine synthase activity
AMICO_RS01885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMICO_RS01890	COG0017	Asparaginyl-tRNA synthetase
AMICO_RS01895	COG0318	PFAM AMP-dependent synthetase and ligase
AMICO_RS01900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMICO_RS01900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMICO_RS01915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMICO_RS01925	COG1802	Transcriptional regulator
AMICO_RS01935	COG2738	Putative neutral zinc metallopeptidase
AMICO_RS01955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AMICO_RS01965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMICO_RS01970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AMICO_RS01975	COG1058	Belongs to the CinA family
AMICO_RS01975	COG1546	Belongs to the CinA family
AMICO_RS01980	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AMICO_RS02005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMICO_RS02020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMICO_RS02025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AMICO_RS02030	COG2033	superoxide reductase activity
AMICO_RS02045	COG0426	domain, Protein
AMICO_RS02060	COG0252	asparaginase activity
AMICO_RS02065	COG2270	Major facilitator Superfamily
AMICO_RS02090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AMICO_RS02100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMICO_RS02105	COG1560	Kdo2-lipid A biosynthetic process
AMICO_RS02115	COG0765	amino acid transport
AMICO_RS02125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMICO_RS02145	COG2186	Transcriptional regulator
AMICO_RS02150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMICO_RS02165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMICO_RS02195	COG2205	protein histidine kinase activity
AMICO_RS02200	COG2116	formate transmembrane transporter activity
AMICO_RS02220	COG2096	Adenosyltransferase
AMICO_RS02225	COG1414	Transcriptional regulator
AMICO_RS02235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMICO_RS02245	COG2358	TRAP transporter, solute receptor (TAXI family
AMICO_RS02280	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AMICO_RS02285	COG0732	type I restriction modification DNA specificity domain
AMICO_RS02290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AMICO_RS02300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMICO_RS02310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMICO_RS02315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS02325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS02335	COG0626	cystathionine gamma-synthase activity
AMICO_RS02340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMICO_RS02360	COG0601	transmembrane transport
AMICO_RS02365	COG0747	negative chemotaxis
AMICO_RS02385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMICO_RS02410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AMICO_RS02415	COG0668	transmembrane transport
AMICO_RS02460	COG1136	(ABC) transporter
AMICO_RS02465	COG0577	efflux transmembrane transporter activity
AMICO_RS02465	COG1136	(ABC) transporter
AMICO_RS02475	COG0460	homoserine dehydrogenase
AMICO_RS02485	COG1278	Cold shock
AMICO_RS02495	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AMICO_RS02500	COG1984	allophanate hydrolase subunit 2
AMICO_RS02505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AMICO_RS02510	COG4336	lyase activity
AMICO_RS02565	COG1802	Transcriptional regulator
AMICO_RS02585	COG0045	succinate-CoA ligase (ADP-forming) activity
AMICO_RS02590	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AMICO_RS02600	COG0436	Aminotransferase
AMICO_RS02605	COG0460	homoserine dehydrogenase
AMICO_RS02625	COG0251	oxidation-reduction process
AMICO_RS02630	COG2855	membrane
AMICO_RS02635	COG0583	DNA-binding transcription factor activity
AMICO_RS02640	COG0133	tryptophan synthase activity
AMICO_RS02645	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AMICO_RS02650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMICO_RS02670	COG2183	response to ionizing radiation
AMICO_RS02680	COG2359	stage V sporulation protein S
AMICO_RS02685	COG0124	histidyl-tRNA synthetase
AMICO_RS02690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMICO_RS02695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMICO_RS02715	COG0583	DNA-binding transcription factor activity
AMICO_RS02720	COG0442	prolyl-tRNA aminoacylation
AMICO_RS02750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AMICO_RS02755	COG0228	four-way junction DNA binding
AMICO_RS02760	COG1837	Belongs to the UPF0109 family
AMICO_RS02770	COG4752	Belongs to the RNA methyltransferase TrmD family
AMICO_RS02770	COG0336	Belongs to the RNA methyltransferase TrmD family
AMICO_RS02775	COG0335	large ribosomal subunit rRNA binding
AMICO_RS02790	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AMICO_RS02805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AMICO_RS02810	COG4463	regulation of RNA biosynthetic process
AMICO_RS02815	COG0542	response to heat
AMICO_RS02855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMICO_RS02870	COG0733	neurotransmitter:sodium symporter activity
AMICO_RS02880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMICO_RS02885	COG0083	homoserine kinase activity
AMICO_RS02900	COG1137	ATPase activity
AMICO_RS02920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMICO_RS02925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMICO_RS02930	COG0459	protein refolding
AMICO_RS02935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMICO_RS02935	COG0519	Catalyzes the synthesis of GMP from XMP
AMICO_RS02940	COG0628	permease
AMICO_RS02950	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMICO_RS02955	COG0358	DNA primase activity
AMICO_RS02960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AMICO_RS02965	COG0148	phosphopyruvate hydratase activity
AMICO_RS02970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AMICO_RS02980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMICO_RS02985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMICO_RS02990	COG0535	radical SAM domain protein
AMICO_RS03000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AMICO_RS03000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AMICO_RS03010	COG1490	D-aminoacyl-tRNA deacylase activity
AMICO_RS03015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMICO_RS03020	COG2003	Belongs to the UPF0758 family
AMICO_RS03025	COG1077	Cell shape determining protein MreB Mrl
AMICO_RS03040	COG0768	penicillin binding
AMICO_RS03045	COG0850	regulation of cytokinetic process
AMICO_RS03050	COG2894	cell division
AMICO_RS03055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AMICO_RS03060	COG0772	Belongs to the SEDS family
AMICO_RS03075	COG1530	ribonuclease E activity
AMICO_RS03085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AMICO_RS03090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AMICO_RS03095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMICO_RS03095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMICO_RS03100	COG0084	hydrolase, TatD family'
AMICO_RS03105	COG0343	queuine tRNA-ribosyltransferase activity
AMICO_RS03110	COG0009	L-threonylcarbamoyladenylate synthase
AMICO_RS03120	COG0085	RNA polymerase activity
AMICO_RS03125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMICO_RS03135	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMICO_RS03145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMICO_RS03150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AMICO_RS03155	COG0051	transcription antitermination factor activity, RNA binding
AMICO_RS03160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMICO_RS03165	COG0088	Forms part of the polypeptide exit tunnel
AMICO_RS03175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMICO_RS03180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMICO_RS03190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMICO_RS03195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AMICO_RS03200	COG0255	Belongs to the universal ribosomal protein uL29 family
AMICO_RS03205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMICO_RS03210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMICO_RS03215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMICO_RS03220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMICO_RS03225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMICO_RS03230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMICO_RS03235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMICO_RS03240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMICO_RS03245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMICO_RS03250	COG1841	ribosomal large subunit assembly
AMICO_RS03260	COG0201	protein transport
AMICO_RS03280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMICO_RS03285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMICO_RS03290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMICO_RS03295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMICO_RS03300	COG0202	RNA polymerase activity
AMICO_RS03305	COG0203	ribosomal protein L17
AMICO_RS03310	COG1122	ATPase activity
AMICO_RS03320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AMICO_RS03325	COG0101	tRNA pseudouridine synthase activity
AMICO_RS03330	COG1077	Cell shape determining protein MreB Mrl
AMICO_RS03350	COG0454	-acetyltransferase
AMICO_RS03400	COG0140	phosphoribosyl-ATP diphosphatase activity
AMICO_RS03400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMICO_RS03405	COG0107	imidazoleglycerol-phosphate synthase activity
AMICO_RS03410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMICO_RS03420	COG0131	Imidazoleglycerol-phosphate dehydratase
AMICO_RS03425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMICO_RS03430	COG0124	histidyl-tRNA synthetase
AMICO_RS03435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMICO_RS03440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AMICO_RS03450	COG0330	HflC and HflK could
AMICO_RS03455	COG0495	leucyl-tRNA aminoacylation
AMICO_RS03465	COG0268	Binds directly to 16S ribosomal RNA
AMICO_RS03470	COG1199	ATP-dependent helicase activity
AMICO_RS03475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AMICO_RS03485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMICO_RS03490	COG0706	membrane insertase activity
AMICO_RS03495	COG1847	R3H domain protein
AMICO_RS03515	COG0745	RESPONSE REGULATOR receiver
AMICO_RS03520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMICO_RS03525	COG1185	polyribonucleotide nucleotidyltransferase activity
AMICO_RS03530	COG0756	dUTP diphosphatase activity
AMICO_RS03535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AMICO_RS03540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AMICO_RS03550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMICO_RS03555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AMICO_RS03560	COG0569	domain protein
AMICO_RS03565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMICO_RS03570	COG0072	phenylalanine-tRNA ligase activity
AMICO_RS03570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMICO_RS03590	COG1193	negative regulation of DNA recombination
AMICO_RS03605	COG1414	Transcriptional regulator
AMICO_RS03620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMICO_RS03625	COG2358	TRAP transporter, solute receptor (TAXI family
AMICO_RS03635	COG0254	rRNA binding
AMICO_RS03640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AMICO_RS03645	COG3872	metal-dependent enzyme
AMICO_RS03650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMICO_RS03655	COG2890	protein-(glutamine-N5) methyltransferase activity
AMICO_RS03660	COG0492	ferredoxin-NADP+ reductase activity
AMICO_RS03700	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AMICO_RS03720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMICO_RS03725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMICO_RS03730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMICO_RS03740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMICO_RS03755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMICO_RS03765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AMICO_RS03770	COG0193	aminoacyl-tRNA hydrolase activity
AMICO_RS03775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AMICO_RS03780	COG3956	TIGRFAM MazG family protein
AMICO_RS03790	COG1702	phosphate starvation-inducible protein PhoH
AMICO_RS03805	COG4536	flavin adenine dinucleotide binding
AMICO_RS03810	COG0295	cytidine deaminase activity
AMICO_RS03815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMICO_RS03825	COG0752	glycyl-tRNA synthetase alpha subunit
AMICO_RS03830	COG0751	glycine-tRNA ligase activity
AMICO_RS03840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AMICO_RS03845	COG0574	Belongs to the PEP-utilizing enzyme family
AMICO_RS03845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMICO_RS03885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AMICO_RS03960	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AMICO_RS03965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMICO_RS03970	COG0556	nucleotide-excision repair
AMICO_RS03975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMICO_RS03980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMICO_RS03985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMICO_RS03995	COG0601	transmembrane transport
AMICO_RS04000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMICO_RS04005	COG0444	Belongs to the ABC transporter superfamily
AMICO_RS04010	COG4608	Belongs to the ABC transporter superfamily
AMICO_RS04025	COG0736	holo-[acyl-carrier-protein] synthase activity
AMICO_RS04030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AMICO_RS04030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AMICO_RS04035	COG0802	atpase or kinase
AMICO_RS04040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMICO_RS04050	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMICO_RS04050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMICO_RS04055	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMICO_RS04075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMICO_RS04090	COG1269	ATP hydrolysis coupled proton transport
AMICO_RS04095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMICO_RS04100	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
AMICO_RS04115	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AMICO_RS04130	COG2001	Belongs to the MraZ family
AMICO_RS04135	COG0275	rRNA processing
AMICO_RS04150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMICO_RS04155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AMICO_RS04160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMICO_RS04165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMICO_RS04175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMICO_RS04180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMICO_RS04185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMICO_RS04200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AMICO_RS04220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMICO_RS04235	COG1660	Displays ATPase and GTPase activities
AMICO_RS04240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AMICO_RS04245	COG1481	regulation of sporulation
AMICO_RS04255	COG0126	phosphoglycerate kinase activity
AMICO_RS04285	COG0799	negative regulation of ribosome biogenesis
AMICO_RS04290	COG1316	TRANSCRIPTIONal
AMICO_RS04295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMICO_RS04300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMICO_RS04305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMICO_RS04315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMICO_RS04320	COG0497	DNA recombination
AMICO_RS04325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMICO_RS04330	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AMICO_RS04335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMICO_RS04345	COG1722	exodeoxyribonuclease VII activity
AMICO_RS04350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMICO_RS04365	COG0312	modulator of DNA gyrase
AMICO_RS04375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AMICO_RS04385	COG2078	PFAM AMMECR1 domain protein
AMICO_RS04385	COG3885	ferrous iron binding
AMICO_RS04390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMICO_RS04395	COG2247	cell wall binding repeat
AMICO_RS04395	COG2385	sporulation resulting in formation of a cellular spore
AMICO_RS04405	COG2255	four-way junction helicase activity
AMICO_RS04410	COG0632	four-way junction helicase activity
AMICO_RS04415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMICO_RS04420	COG0217	transcriptional regulatory protein
AMICO_RS04425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AMICO_RS04440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMICO_RS04445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMICO_RS04450	COG0750	zinc metalloprotease
AMICO_RS04455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMICO_RS04460	COG0575	Belongs to the CDS family
AMICO_RS04465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMICO_RS04470	COG1573	uracil-dna glycosylase
AMICO_RS04485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMICO_RS04490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AMICO_RS04495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMICO_RS04500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AMICO_RS04505	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AMICO_RS04520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMICO_RS04530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMICO_RS04530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMICO_RS04535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMICO_RS04535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMICO_RS04555	COG0285	dihydrofolate synthase activity
AMICO_RS04560	COG0525	valine-tRNA ligase activity
AMICO_RS04565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AMICO_RS04570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMICO_RS04575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMICO_RS04580	COG0740	serine-type endopeptidase activity
AMICO_RS04585	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMICO_RS04600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMICO_RS04620	COG1704	LemA family
AMICO_RS04635	COG3842	ATPase activity
AMICO_RS04645	COG1840	ABC-type Fe3 transport system, periplasmic component
AMICO_RS04660	COG1760	l-serine dehydratase
AMICO_RS04670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMICO_RS04680	COG3681	Belongs to the UPF0597 family
AMICO_RS04685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS04685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS04725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS04740	COG4249	Peptidase C14 caspase catalytic subunit p20
AMICO_RS04800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AMICO_RS04805	COG1408	metallophosphoesterase
AMICO_RS04885	COG4948	Mandelate Racemase Muconate Lactonizing
AMICO_RS04915	COG0564	pseudouridine synthase activity
AMICO_RS04950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMICO_RS04955	COG0196	riboflavin kinase activity
AMICO_RS04960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMICO_RS04965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMICO_RS04970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMICO_RS04980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMICO_RS04990	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AMICO_RS04995	COG0195	Participates in both transcription termination and antitermination
AMICO_RS05000	COG0779	Required for maturation of 30S ribosomal subunits
AMICO_RS05005	COG0516	GMP reductase activity
AMICO_RS05005	COG0517	IMP dehydrogenase activity
AMICO_RS05010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMICO_RS05015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMICO_RS05015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMICO_RS05020	COG4956	integral membrane protein (PIN domain superfamily)
AMICO_RS05025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMICO_RS05030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMICO_RS05035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AMICO_RS05040	COG1394	ATPase activity, coupled to movement of substances
AMICO_RS05045	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AMICO_RS05050	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AMICO_RS05075	COG1269	ATP hydrolysis coupled proton transport
AMICO_RS05085	COG0517	IMP dehydrogenase activity
AMICO_RS05085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMICO_RS05085	COG0617	tRNA 3'-terminal CCA addition
AMICO_RS05090	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AMICO_RS05095	COG1473	amidohydrolase
AMICO_RS05100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMICO_RS05110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMICO_RS05110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMICO_RS05120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMICO_RS05120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMICO_RS05125	COG0322	excinuclease ABC activity
AMICO_RS05130	COG0215	cysteine-tRNA ligase activity
AMICO_RS05150	COG0500	methyltransferase
AMICO_RS05160	COG1592	Rubrerythrin
AMICO_RS05175	COG0739	heme binding
AMICO_RS05185	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AMICO_RS05190	COG4974	Belongs to the 'phage' integrase family
AMICO_RS05195	COG0494	nUDIX hydrolase
AMICO_RS05210	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMICO_RS05225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMICO_RS05235	COG0539	negative regulation of cytoplasmic translation
AMICO_RS05240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMICO_RS05245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMICO_RS05250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AMICO_RS05255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AMICO_RS05260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AMICO_RS05265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMICO_RS05270	COG0402	S-adenosylhomocysteine deaminase activity
AMICO_RS05275	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AMICO_RS05280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMICO_RS05285	COG1570	exodeoxyribonuclease VII activity
AMICO_RS05290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMICO_RS05310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMICO_RS05315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMICO_RS05320	COG4496	protein, YerC YecD
AMICO_RS05330	COG1067	ATP-dependent peptidase activity
AMICO_RS05335	COG0482	sulfurtransferase activity
AMICO_RS05340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMICO_RS05350	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AMICO_RS05360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMICO_RS05370	COG0552	protein localization to endoplasmic reticulum
AMICO_RS05375	COG1774	PSP1 C-terminal conserved region
AMICO_RS05380	COG0470	DNA polymerase III
AMICO_RS05385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMICO_RS05390	COG0750	zinc metalloprotease
AMICO_RS05395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMICO_RS05400	COG0709	Synthesizes selenophosphate from selenide and ATP
AMICO_RS05405	COG2814	Major facilitator Superfamily
AMICO_RS05415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AMICO_RS05420	COG0571	ribonuclease III activity
AMICO_RS05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AMICO_RS05430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMICO_RS05440	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMICO_RS05445	COG2070	2-Nitropropane dioxygenase
AMICO_RS05450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMICO_RS05455	COG0416	fatty acid biosynthetic process
AMICO_RS05460	COG2030	dehydratase
AMICO_RS05465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMICO_RS05475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMICO_RS05480	COG1323	Belongs to the UPF0348 family
AMICO_RS05485	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMICO_RS05490	COG0742	ribosomal rna small subunit methyltransferase
AMICO_RS05495	COG1720	tRNA m6t6A37 methyltransferase activity
AMICO_RS05500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMICO_RS05505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMICO_RS05505	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMICO_RS05505	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMICO_RS05505	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMICO_RS05515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMICO_RS05525	COG1160	GTP binding
AMICO_RS05530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AMICO_RS05535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AMICO_RS05545	COG0194	GDP metabolic process
AMICO_RS05550	COG2052	Domain of unknown function (DUF370)
AMICO_RS05555	COG1561	YicC-like family, N-terminal region
AMICO_RS05560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMICO_RS05565	COG0204	Acyl-transferase
AMICO_RS05565	COG0318	PFAM AMP-dependent synthetase and ligase
AMICO_RS05570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AMICO_RS05575	COG1187	pseudouridine synthase activity
AMICO_RS05580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMICO_RS05590	COG0180	Tryptophanyl-tRNA synthetase
AMICO_RS05595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMICO_RS05735	COG0582	viral genome integration into host DNA
AMICO_RS05765	COG1484	DNA-dependent DNA replication
AMICO_RS05775	COG0756	dUTP diphosphatase activity
AMICO_RS05835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMICO_RS05855	COG0582	viral genome integration into host DNA
AMICO_RS05865	COG1141	Ferredoxin
AMICO_RS05870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMICO_RS05875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMICO_RS05890	COG1921	L-seryl-tRNASec selenium transferase activity
AMICO_RS05910	COG0481	GTPase activity
AMICO_RS05915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMICO_RS05920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMICO_RS05925	COG0047	phosphoribosylformylglycinamidine synthase activity
AMICO_RS05935	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AMICO_RS05940	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMICO_RS05945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AMICO_RS05950	COG0138	bifunctional purine biosynthesis protein purh
AMICO_RS05955	COG0151	Belongs to the GarS family
AMICO_RS05960	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AMICO_RS05975	COG0137	argininosuccinate synthase activity
AMICO_RS05980	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AMICO_RS05985	COG1994	Peptidase M50
AMICO_RS05990	COG0617	tRNA 3'-terminal CCA addition
AMICO_RS05990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMICO_RS05990	COG3620	sequence-specific DNA binding
AMICO_RS06000	COG0210	DNA helicase
AMICO_RS06005	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AMICO_RS06015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AMICO_RS06025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMICO_RS06030	COG2252	PERMEase
AMICO_RS06035	COG0233	cytoplasmic translational termination
AMICO_RS06040	COG0528	UMP kinase activity
AMICO_RS06045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMICO_RS06050	COG0052	Belongs to the universal ribosomal protein uS2 family
AMICO_RS06055	COG1937	Protein conserved in bacteria
AMICO_RS06065	COG1881	PFAM PEBP family protein
AMICO_RS06075	COG2195	Cleaves the N-terminal amino acid of tripeptides
AMICO_RS06080	COG2239	Acts as a magnesium transporter
AMICO_RS06110	COG2201	protein-glutamate methylesterase activity
AMICO_RS06135	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMICO_RS06150	COG2197	response regulator
AMICO_RS06155	COG2203	Gaf domain
AMICO_RS06155	COG4585	Histidine kinase
AMICO_RS06160	COG0183	Belongs to the thiolase family
AMICO_RS06165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMICO_RS06170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMICO_RS06185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMICO_RS06195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AMICO_RS06235	COG2235	arginine
AMICO_RS06250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMICO_RS06255	COG3949	Membrane
AMICO_RS06265	COG1592	Rubrerythrin
AMICO_RS06270	COG0590	tRNA wobble adenosine to inosine editing
AMICO_RS06290	COG0003	Pfam Anion-transporting ATPase
AMICO_RS06310	COG1362	aminopeptidase activity
AMICO_RS06315	COG2379	hydroxypyruvate reductase
AMICO_RS06360	COG1335	isochorismatase
AMICO_RS06365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMICO_RS06370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMICO_RS06375	COG2423	ornithine cyclodeaminase activity
AMICO_RS06405	COG0494	nUDIX hydrolase
AMICO_RS06420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMICO_RS06420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AMICO_RS06430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMICO_RS06435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMICO_RS06440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMICO_RS06445	COG3261	NADH dehydrogenase
AMICO_RS06445	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AMICO_RS06450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMICO_RS06450	COG0649	NAD binding
AMICO_RS06455	COG3260	NADH ubiquinone oxidoreductase 20
AMICO_RS06465	COG0651	ATP synthesis coupled electron transport
AMICO_RS06480	COG2111	Na H antiporter
AMICO_RS06480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AMICO_RS06490	COG1320	monovalent cation:proton antiporter activity
AMICO_RS06495	COG2212	antiporter activity
AMICO_RS06500	COG1863	multisubunit Na H antiporter MnhE subunit
AMICO_RS06525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMICO_RS06530	COG0598	Magnesium transport protein CorA
AMICO_RS06560	COG0569	domain protein
AMICO_RS06580	COG1253	flavin adenine dinucleotide binding
AMICO_RS06595	COG1346	cytolysis
AMICO_RS06600	COG1380	Effector of murein hydrolase LrgA
AMICO_RS06605	COG0251	oxidation-reduction process
AMICO_RS06625	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMICO_RS06630	COG0473	3-isopropylmalate dehydrogenase activity
AMICO_RS06635	COG1802	Transcriptional regulator
AMICO_RS06640	COG1454	alcohol dehydrogenase
AMICO_RS06645	COG3875	lactate racemase activity
AMICO_RS06650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS06650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS06655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS06660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS06670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMICO_RS06675	COG2186	Transcriptional regulator
AMICO_RS06690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMICO_RS06695	COG1144	Oxidoreductase
AMICO_RS06700	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMICO_RS06705	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMICO_RS06730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS06745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMICO_RS06750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AMICO_RS06790	COG0426	domain, Protein
AMICO_RS06795	COG3189	MarR family transcriptional regulator
AMICO_RS06800	COG3093	addiction module antidote protein HigA
AMICO_RS06820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMICO_RS06825	COG2814	Major facilitator Superfamily
AMICO_RS06830	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AMICO_RS06835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS06845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS06865	COG1309	transcriptional regulator
AMICO_RS06880	COG1136	(ABC) transporter
AMICO_RS06885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMICO_RS06900	COG1335	isochorismatase
AMICO_RS06925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMICO_RS06945	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMICO_RS06950	COG2197	response regulator
AMICO_RS06955	COG0037	tRNA processing
AMICO_RS06960	COG0719	Fe-S assembly protein
AMICO_RS06965	COG0396	ATPase activity
AMICO_RS06970	COG0166	Belongs to the GPI family
AMICO_RS06980	COG0543	2 iron, 2 sulfur cluster binding
AMICO_RS06995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMICO_RS07000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMICO_RS07005	COG0154	amidase activity
AMICO_RS07010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMICO_RS07015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMICO_RS07020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMICO_RS07030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMICO_RS07035	COG2333	competence protein COMEC
AMICO_RS07035	COG0658	competence protein
AMICO_RS07055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AMICO_RS07060	COG1773	rubredoxin
AMICO_RS07065	COG0006	proline dipeptidase activity
AMICO_RS07070	COG0709	Synthesizes selenophosphate from selenide and ATP
AMICO_RS07075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AMICO_RS07080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AMICO_RS07085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMICO_RS07090	COG1115	amino acid carrier protein
AMICO_RS07110	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AMICO_RS07140	COG0733	neurotransmitter:sodium symporter activity
AMICO_RS07150	COG0409	Hydrogenase expression formation protein
AMICO_RS07160	COG1692	metallophosphoesterase
AMICO_RS07165	COG1418	mRNA catabolic process
AMICO_RS07175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AMICO_RS07180	COG3599	regulation of cell shape
AMICO_RS07190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AMICO_RS07200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMICO_RS07205	COG1469	GTP cyclohydrolase I activity
AMICO_RS07210	COG0720	synthase
AMICO_RS07225	COG0305	Participates in initiation and elongation during chromosome replication
AMICO_RS07230	COG0359	binds to the 23S rRNA
AMICO_RS07240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMICO_RS07245	COG0629	single-stranded DNA binding
AMICO_RS07250	COG0360	Binds together with S18 to 16S ribosomal RNA
AMICO_RS07260	COG0018	arginyl-trna synthetase
AMICO_RS07270	COG0653	protein targeting
AMICO_RS07275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMICO_RS07280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AMICO_RS07310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMICO_RS07325	COG0537	adenosine 5'-monophosphoramidase activity
AMICO_RS07330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMICO_RS07340	COG0484	heat shock protein binding
AMICO_RS07350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMICO_RS07355	COG1420	regulation of RNA biosynthetic process
AMICO_RS07365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMICO_RS07370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AMICO_RS07385	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMICO_RS07400	COG1966	Carbon starvation protein
AMICO_RS07415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AMICO_RS07420	COG2861	carbohydrate metabolic process
AMICO_RS07425	COG0793	Belongs to the peptidase S41A family
AMICO_RS07430	COG0739	heme binding
AMICO_RS07435	COG2177	Part of the ABC transporter FtsEX involved in
AMICO_RS07440	COG2884	Cell division ATP-binding protein ftsE
AMICO_RS07445	COG3958	Transketolase
AMICO_RS07450	COG3959	Transketolase, thiamine diphosphate binding domain
AMICO_RS07465	COG0424	maF-like protein
AMICO_RS07475	COG1968	undecaprenyl-diphosphatase activity
AMICO_RS07480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AMICO_RS07485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMICO_RS07490	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMICO_RS07515	COG0504	CTP synthase activity
AMICO_RS07525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AMICO_RS07550	COG0205	6-phosphofructokinase activity
AMICO_RS07565	COG0497	DNA recombination
AMICO_RS07575	COG0859	PFAM glycosyl transferase family 9
AMICO_RS07580	COG0438	transferase activity, transferring glycosyl groups
AMICO_RS07585	COG0438	transferase activity, transferring glycosyl groups
AMICO_RS07595	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AMICO_RS07605	COG1519	Transferase
AMICO_RS07615	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AMICO_RS07620	COG1663	tetraacyldisaccharide 4'-kinase activity
AMICO_RS07625	COG1132	(ABC) transporter
AMICO_RS07635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMICO_RS07640	COG3494	Protein of unknown function (DUF1009)
AMICO_RS07650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AMICO_RS07655	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMICO_RS07660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AMICO_RS07665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AMICO_RS07670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AMICO_RS07690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMICO_RS07695	COG0406	alpha-ribazole phosphatase activity
AMICO_RS07720	COG0165	Argininosuccinate lyase
AMICO_RS07730	COG1185	polyribonucleotide nucleotidyltransferase activity
AMICO_RS07735	COG2201	protein-glutamate methylesterase activity
AMICO_RS07745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AMICO_RS07750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AMICO_RS07765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMICO_RS07785	COG0792	nuclease activity
AMICO_RS07790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMICO_RS07795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AMICO_RS07800	COG0681	Belongs to the peptidase S26 family
AMICO_RS07820	COG0824	Thioesterase
AMICO_RS07835	COG2239	Acts as a magnesium transporter
AMICO_RS07840	COG2423	ornithine cyclodeaminase activity
AMICO_RS07850	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AMICO_RS07855	COG3404	Formiminotransferase-cyclodeaminase
AMICO_RS07865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS07870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS07875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS07880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMICO_RS07890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMICO_RS07895	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AMICO_RS07910	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AMICO_RS07915	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
AMICO_RS07930	COG3259	Nickel-dependent hydrogenase
AMICO_RS07935	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AMICO_RS07940	COG3383	formate dehydrogenase (NAD+) activity
AMICO_RS07960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AMICO_RS07965	COG4662	Binding-protein-dependent transport system inner membrane component
AMICO_RS07970	COG2998	abc-type tungstate transport system, permease component
AMICO_RS08000	COG3845	ABC transporter
AMICO_RS08005	COG4603	Belongs to the binding-protein-dependent transport system permease family
AMICO_RS08015	COG1744	ABC transporter substrate-binding protein PnrA-like
AMICO_RS08020	COG0737	Belongs to the 5'-nucleotidase family
AMICO_RS08025	COG1573	uracil-dna glycosylase
AMICO_RS08050	COG1840	ABC-type Fe3 transport system, periplasmic component
AMICO_RS08055	COG0095	Lipoate-protein ligase
AMICO_RS08070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMICO_RS08075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMICO_RS08080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMICO_RS08085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMICO_RS08090	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMICO_RS08095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS08095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS08105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS08115	COG0022	dehydrogenase e1 component
AMICO_RS08120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMICO_RS08130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMICO_RS08145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AMICO_RS08150	COG0284	orotidine-5'-phosphate decarboxylase activity
AMICO_RS08155	COG0167	dihydroorotate dehydrogenase activity
AMICO_RS08160	COG0543	2 iron, 2 sulfur cluster binding
AMICO_RS08165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMICO_RS08170	COG0540	Belongs to the ATCase OTCase family
AMICO_RS08175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AMICO_RS08180	COG0436	Aminotransferase
AMICO_RS08185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMICO_RS08190	COG1414	Transcriptional regulator
AMICO_RS08205	COG0697	spore germination
AMICO_RS08210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMICO_RS08220	COG0318	PFAM AMP-dependent synthetase and ligase
AMICO_RS08235	COG1691	(AIR) carboxylase
AMICO_RS08245	COG1473	amidohydrolase
AMICO_RS08270	COG1217	gtp-binding protein TYPA
AMICO_RS08280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMICO_RS08305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMICO_RS08355	COG1331	Highly conserved protein containing a thioredoxin domain
AMICO_RS08365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AMICO_RS08375	COG0460	homoserine dehydrogenase
AMICO_RS08390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AMICO_RS08400	COG0187	DNA topoisomerase II activity
AMICO_RS08410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMICO_RS08425	COG1802	Transcriptional regulator
AMICO_RS08435	COG1473	amidohydrolase
AMICO_RS08445	COG0747	negative chemotaxis
AMICO_RS08455	COG4608	Belongs to the ABC transporter superfamily
AMICO_RS08460	COG0444	Belongs to the ABC transporter superfamily
AMICO_RS08465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMICO_RS08475	COG0617	tRNA 3'-terminal CCA addition
AMICO_RS08480	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AMICO_RS08485	COG3875	lactate racemase activity
AMICO_RS08490	COG0800	Aldolase
AMICO_RS08495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMICO_RS08500	COG2011	ABC-type metal ion transport system permease component
AMICO_RS08510	COG4948	Mandelate Racemase Muconate Lactonizing
AMICO_RS08525	COG1414	Transcriptional regulator
AMICO_RS08540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS08545	COG2721	sulfolactate sulfo-lyase activity
AMICO_RS08550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AMICO_RS08555	COG0573	inorganic phosphate transmembrane transporter activity
AMICO_RS08560	COG0581	inorganic phosphate transmembrane transporter activity
AMICO_RS08565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMICO_RS08575	COG0745	RESPONSE REGULATOR receiver
AMICO_RS08580	COG5002	protein histidine kinase activity
AMICO_RS08595	COG1408	metallophosphoesterase
AMICO_RS08600	COG1414	Transcriptional regulator
AMICO_RS08610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS08610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS08615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS08635	COG2364	Membrane
AMICO_RS08640	COG0405	Gamma-glutamyltransferase
AMICO_RS08650	COG1785	Belongs to the alkaline phosphatase family
AMICO_RS08665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS08675	COG0066	3-isopropylmalate dehydratase activity
AMICO_RS08730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMICO_RS08740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AMICO_RS08745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AMICO_RS08775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMICO_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
AMICO_RS08825	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AMICO_RS08900	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS08900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS08905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS08910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS08915	COG0436	Aminotransferase
AMICO_RS08935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMICO_RS08940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMICO_RS08965	COG3123	guanosine phosphorylase activity
AMICO_RS08975	COG0628	permease
AMICO_RS08980	COG1921	L-seryl-tRNASec selenium transferase activity
AMICO_RS08985	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AMICO_RS08990	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMICO_RS08995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMICO_RS09010	COG2358	TRAP transporter, solute receptor (TAXI family
AMICO_RS09025	COG1278	Cold shock
AMICO_RS09035	COG1970	mechanosensitive ion channel activity
AMICO_RS09045	COG0601	transmembrane transport
AMICO_RS09050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMICO_RS09075	COG1091	dTDP-4-dehydrorhamnose reductase activity
AMICO_RS09085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMICO_RS09090	COG0156	8-amino-7-oxononanoate synthase activity
AMICO_RS09110	COG0281	malic enzyme
AMICO_RS09115	COG0318	PFAM AMP-dependent synthetase and ligase
AMICO_RS09120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMICO_RS09120	COG0519	Catalyzes the synthesis of GMP from XMP
AMICO_RS09125	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AMICO_RS09135	COG1473	amidohydrolase
AMICO_RS09160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMICO_RS09165	COG0443	Heat shock 70 kDa protein
AMICO_RS09190	COG2358	TRAP transporter, solute receptor (TAXI family
AMICO_RS09205	COG0420	3'-5' exonuclease activity
AMICO_RS09230	COG1827	regulation of RNA biosynthetic process
AMICO_RS09255	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AMICO_RS09280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AMICO_RS09295	COG1047	Peptidyl-prolyl cis-trans
AMICO_RS09300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMICO_RS09310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMICO_RS09315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS09315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS09320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS09320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS09325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS09340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMICO_RS09345	COG1414	Transcriptional regulator
AMICO_RS09350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AMICO_RS09360	COG3426	butyrate kinase activity
AMICO_RS09365	COG0280	phosphate acetyltransferase
AMICO_RS09370	COG0280	phosphate acetyltransferase
AMICO_RS09375	COG3426	butyrate kinase activity
AMICO_RS09405	COG1739	Uncharacterized protein family UPF0029
AMICO_RS09415	COG1475	DNA binding
AMICO_RS09420	COG1192	Involved in chromosome partitioning
AMICO_RS09425	COG0357	Ribosomal RNA small subunit methyltransferase G
AMICO_RS09430	COG1525	nuclease
AMICO_RS09455	COG1473	amidohydrolase
AMICO_RS09460	COG1473	amidohydrolase
AMICO_RS09465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMICO_RS09470	COG1121	(ABC) transporter
AMICO_RS09475	COG0803	Belongs to the bacterial solute-binding protein 9 family
AMICO_RS09515	COG4585	Histidine kinase
AMICO_RS09525	COG2414	aldehyde ferredoxin oxidoreductase
AMICO_RS09540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMICO_RS09545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AMICO_RS09550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS09555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AMICO_RS09555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AMICO_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
AMICO_RS09570	COG0667	Aldo Keto reductase
AMICO_RS09580	COG1228	amidohydrolase
AMICO_RS09585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMICO_RS09590	COG1840	ABC-type Fe3 transport system, periplasmic component
AMICO_RS09595	COG1178	ABC-type Fe3 transport system permease component
AMICO_RS09600	COG3842	ATPase activity
AMICO_RS09605	COG1924	4 iron, 4 sulfur cluster binding
AMICO_RS09635	COG2217	Heavy metal translocating P-type atpase
AMICO_RS09655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMICO_RS09660	COG1473	amidohydrolase
AMICO_RS09665	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AMICO_RS09670	COG2195	Cleaves the N-terminal amino acid of tripeptides
AMICO_RS09680	COG2986	histidine ammonia-lyase
AMICO_RS09685	COG1151	hydroxylamine reductase activity
AMICO_RS09695	COG1959	2 iron, 2 sulfur cluster binding
AMICO_RS09700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMICO_RS09745	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMICO_RS09750	COG1196	nuclear chromosome segregation
AMICO_RS09750	COG3264	Mechanosensitive ion channel
AMICO_RS09755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMICO_RS09760	COG1309	transcriptional regulator
AMICO_RS09775	COG1609	Transcriptional regulator
AMICO_RS09785	COG0671	phosphoesterase, PA-phosphatase related
AMICO_RS09795	COG0444	Belongs to the ABC transporter superfamily
AMICO_RS09815	COG3473	Maleate cis-trans isomerase
AMICO_RS09825	COG3328	transposase activity
AMICO_RS09830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AMICO_RS09830	COG2199	diguanylate cyclase activity
AMICO_RS09855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMICO_RS09860	COG1480	7TM receptor with intracellular HD hydrolase
AMICO_RS09875	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMICO_RS09880	COG1674	ftsk spoiiie
AMICO_RS09895	COG0582	viral genome integration into host DNA
AMICO_RS09905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMICO_RS09945	COG1396	sequence-specific DNA binding
AMICO_RS09950	COG0237	dephospho-CoA kinase activity
AMICO_RS09960	COG3706	GGDEF domain
AMICO_RS10000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain