locus-tag	class	description
H9Q20_RS00005	COG0463	Glycosyl transferase, family 2
H9Q20_RS00015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9Q20_RS00020	COG4413	Urea transporter
H9Q20_RS00035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9Q20_RS00040	COG3291	Pkd domain containing protein
H9Q20_RS00050	COG1950	PFAM Membrane protein of
H9Q20_RS00095	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H9Q20_RS00105	COG1979	alcohol dehydrogenase
H9Q20_RS00130	COG0531	amino acid
H9Q20_RS00140	COG1136	(ABC) transporter
H9Q20_RS00145	COG2003	Belongs to the UPF0758 family
H9Q20_RS00165	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9Q20_RS00170	COG0824	Thioesterase
H9Q20_RS00175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9Q20_RS00190	COG0386	Belongs to the glutathione peroxidase family
H9Q20_RS00225	COG0673	inositol 2-dehydrogenase activity
H9Q20_RS00230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9Q20_RS00235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9Q20_RS00245	COG0142	geranyltranstransferase activity
H9Q20_RS00260	COG2183	response to ionizing radiation
H9Q20_RS00265	COG0183	Belongs to the thiolase family
H9Q20_RS00270	COG2270	Major facilitator Superfamily
H9Q20_RS00285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9Q20_RS00290	COG0545	Peptidyl-prolyl cis-trans isomerase
H9Q20_RS00300	COG3118	belongs to the thioredoxin family
H9Q20_RS00315	COG1393	Belongs to the ArsC family
H9Q20_RS00325	COG1428	Deoxynucleoside kinase
H9Q20_RS00360	COG0151	Belongs to the GarS family
H9Q20_RS00365	COG0519	Catalyzes the synthesis of GMP from XMP
H9Q20_RS00365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9Q20_RS00370	COG0513	Belongs to the DEAD box helicase family
H9Q20_RS00375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9Q20_RS00390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H9Q20_RS00415	COG1335	isochorismatase
H9Q20_RS00430	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9Q20_RS00435	COG0567	Dehydrogenase, E1 component
H9Q20_RS00445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9Q20_RS00460	COG2356	endonuclease I
H9Q20_RS00465	COG0813	purine-nucleoside phosphorylase activity
H9Q20_RS00470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9Q20_RS00480	COG0022	dehydrogenase e1 component
H9Q20_RS00495	COG0823	Involved in the tonB-independent uptake of proteins
H9Q20_RS00495	COG1506	peptidase
H9Q20_RS00505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9Q20_RS00510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9Q20_RS00525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9Q20_RS00525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9Q20_RS00530	COG1187	pseudouridine synthase activity
H9Q20_RS00535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9Q20_RS00545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9Q20_RS00550	COG0505	Belongs to the CarA family
H9Q20_RS00585	COG5002	protein histidine kinase activity
H9Q20_RS00590	COG0745	RESPONSE REGULATOR receiver
H9Q20_RS00600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9Q20_RS00635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9Q20_RS00645	COG0823	Involved in the tonB-independent uptake of proteins
H9Q20_RS00645	COG1506	peptidase
H9Q20_RS00660	COG2264	protein methyltransferase activity
H9Q20_RS00665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H9Q20_RS00670	COG0563	adenylate kinase activity
H9Q20_RS00675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9Q20_RS00695	COG2304	oxidoreductase activity
H9Q20_RS00700	COG2304	oxidoreductase activity
H9Q20_RS00715	COG0714	Associated with various cellular activities
H9Q20_RS00725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9Q20_RS00760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H9Q20_RS00770	COG0673	inositol 2-dehydrogenase activity
H9Q20_RS00775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9Q20_RS00780	COG1607	acyl-coa hydrolase
H9Q20_RS00785	COG1162	GTPase activity
H9Q20_RS00790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H9Q20_RS00800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9Q20_RS00810	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9Q20_RS00825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9Q20_RS00830	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9Q20_RS00835	COG0363	glucosamine-6-phosphate deaminase activity
H9Q20_RS00845	COG4771	TonB-dependent receptor
H9Q20_RS00850	COG3275	phosphorelay sensor kinase activity
H9Q20_RS00855	COG3279	Response regulator of the LytR AlgR family
H9Q20_RS00860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9Q20_RS00895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H9Q20_RS00900	COG3279	Response regulator of the LytR AlgR family
H9Q20_RS00905	COG0702	epimerase
H9Q20_RS00910	COG1629	transport
H9Q20_RS00920	COG3275	phosphorelay sensor kinase activity
H9Q20_RS00925	COG1285	pathogenesis
H9Q20_RS00930	COG1295	ribonuclease BN
H9Q20_RS00935	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9Q20_RS00940	COG0671	phosphoesterase, PA-phosphatase related
H9Q20_RS00945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9Q20_RS00980	COG2373	Large extracellular alpha-helical protein
H9Q20_RS00990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9Q20_RS01000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9Q20_RS01015	COG1960	acyl-CoA dehydrogenase activity
H9Q20_RS01030	COG2027	D-alanyl-D-alanine carboxypeptidase
H9Q20_RS01035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9Q20_RS01040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9Q20_RS01040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9Q20_RS01045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9Q20_RS01070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9Q20_RS01070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9Q20_RS01080	COG0572	uridine kinase
H9Q20_RS01085	COG0724	RNA recognition motif
H9Q20_RS01090	COG0598	Magnesium transport protein CorA
H9Q20_RS01095	COG0006	proline dipeptidase activity
H9Q20_RS01100	COG3340	Belongs to the peptidase S51 family
H9Q20_RS01105	COG1309	transcriptional regulator
H9Q20_RS01120	COG2814	Major facilitator Superfamily
H9Q20_RS01130	COG0539	negative regulation of cytoplasmic translation
H9Q20_RS01130	COG2183	response to ionizing radiation
H9Q20_RS01140	COG0589	response to stress
H9Q20_RS01140	COG0475	glutathione-regulated potassium exporter activity
H9Q20_RS01150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9Q20_RS01155	COG0492	ferredoxin-NADP+ reductase activity
H9Q20_RS01160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9Q20_RS01185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9Q20_RS01185	COG0662	Cupin 2, conserved barrel domain protein
H9Q20_RS01190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9Q20_RS01260	COG2801	Transposase and inactivated derivatives
H9Q20_RS01295	COG2801	Transposase and inactivated derivatives
H9Q20_RS01365	COG1538	Outer membrane efflux protein
H9Q20_RS01375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9Q20_RS01395	COG0038	chloride channel
H9Q20_RS01405	COG2204	response regulator
H9Q20_RS01420	COG0288	reversible hydration of carbon dioxide
H9Q20_RS01430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9Q20_RS01435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9Q20_RS01445	COG3657	addiction module killer protein
H9Q20_RS01450	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9Q20_RS01490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9Q20_RS01495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9Q20_RS01500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9Q20_RS01505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9Q20_RS01515	COG0356	it plays a direct role in the translocation of protons across the membrane
H9Q20_RS01530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9Q20_RS01545	COG0802	atpase or kinase
H9Q20_RS01560	COG1702	phosphate starvation-inducible protein PhoH
H9Q20_RS01570	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9Q20_RS01580	COG0360	Binds together with S18 to 16S ribosomal RNA
H9Q20_RS01585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9Q20_RS01590	COG0359	binds to the 23S rRNA
H9Q20_RS01595	COG1012	belongs to the aldehyde dehydrogenase family
H9Q20_RS01620	COG0531	amino acid
H9Q20_RS01645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9Q20_RS01650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9Q20_RS01650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9Q20_RS01655	COG0484	heat shock protein binding
H9Q20_RS01660	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9Q20_RS01670	COG2949	membrane
H9Q20_RS01675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9Q20_RS01675	COG1017	nitric oxide dioxygenase activity
H9Q20_RS01690	COG1120	ATPase activity
H9Q20_RS01700	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9Q20_RS01700	COG1024	Enoyl-CoA hydratase
H9Q20_RS01710	COG0183	Belongs to the thiolase family
H9Q20_RS01720	COG1960	acyl-CoA dehydrogenase activity
H9Q20_RS01735	COG1418	mRNA catabolic process
H9Q20_RS01755	COG2226	methyltransferase
H9Q20_RS01765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9Q20_RS01770	COG3852	Histidine kinase
H9Q20_RS01775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9Q20_RS01785	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H9Q20_RS01790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9Q20_RS01800	COG1012	belongs to the aldehyde dehydrogenase family
H9Q20_RS01805	COG0534	Mate efflux family protein
H9Q20_RS01810	COG2204	response regulator
H9Q20_RS01825	COG4585	Histidine kinase
H9Q20_RS01835	COG0009	L-threonylcarbamoyladenylate synthase
H9Q20_RS01840	COG3022	response to hydroperoxide
H9Q20_RS01845	COG2890	protein-(glutamine-N5) methyltransferase activity
H9Q20_RS01850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H9Q20_RS01860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9Q20_RS01865	COG0592	DNA-directed DNA polymerase activity
H9Q20_RS01890	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9Q20_RS01905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9Q20_RS01915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H9Q20_RS01920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9Q20_RS01925	COG1970	mechanosensitive ion channel activity
H9Q20_RS01970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9Q20_RS01975	COG0438	transferase activity, transferring glycosyl groups
H9Q20_RS01980	COG0156	8-amino-7-oxononanoate synthase activity
H9Q20_RS02005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9Q20_RS02015	COG1253	flavin adenine dinucleotide binding
H9Q20_RS02035	COG0805	protein transport
H9Q20_RS02040	COG0517	IMP dehydrogenase activity
H9Q20_RS02040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9Q20_RS02045	COG0514	ATP-dependent DNA helicase (RecQ)
H9Q20_RS02055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9Q20_RS02060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9Q20_RS02070	COG2234	aminopeptidase activity
H9Q20_RS02075	COG0436	Aminotransferase
H9Q20_RS02080	COG0436	Aminotransferase
H9Q20_RS02085	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H9Q20_RS02090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9Q20_RS02185	COG2801	Transposase and inactivated derivatives
H9Q20_RS02230	COG0335	large ribosomal subunit rRNA binding
H9Q20_RS02250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9Q20_RS02255	COG1234	tRNA 3'-trailer cleavage
H9Q20_RS02270	COG1760	l-serine dehydratase
H9Q20_RS02290	COG0837	glucose binding
H9Q20_RS02295	COG0308	aminopeptidase N
H9Q20_RS02300	COG0196	riboflavin kinase activity
H9Q20_RS02320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9Q20_RS02325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9Q20_RS02360	COG1194	a g-specific adenine glycosylase
H9Q20_RS02365	COG0776	regulation of translation
H9Q20_RS02370	COG1530	ribonuclease E activity
H9Q20_RS02400	COG0427	acetyl-CoA hydrolase
H9Q20_RS02410	COG3118	belongs to the thioredoxin family
H9Q20_RS02420	COG2161	toxin-antitoxin pair type II binding
H9Q20_RS02425	COG4115	mRNA cleavage
H9Q20_RS02430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9Q20_RS02435	COG0861	Integral membrane protein TerC family
H9Q20_RS02450	COG0488	(ABC) transporter
H9Q20_RS02460	COG3590	peptidase
H9Q20_RS02465	COG1289	transmembrane transporter activity
H9Q20_RS02475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H9Q20_RS02490	COG1960	acyl-CoA dehydrogenase activity
H9Q20_RS02495	COG1022	Amp-dependent synthetase and ligase
H9Q20_RS02550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9Q20_RS02550	COG0515	serine threonine protein kinase
H9Q20_RS02565	COG5002	protein histidine kinase activity
H9Q20_RS02570	COG0745	RESPONSE REGULATOR receiver
H9Q20_RS02575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9Q20_RS02595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9Q20_RS02605	COG3842	ATPase activity
H9Q20_RS02625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9Q20_RS02630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9Q20_RS02640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9Q20_RS02645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9Q20_RS02650	COG3876	Protein conserved in bacteria
H9Q20_RS02675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9Q20_RS02685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9Q20_RS02705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9Q20_RS02710	COG1561	YicC-like family, N-terminal region
H9Q20_RS02715	COG0194	GDP metabolic process
H9Q20_RS02720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9Q20_RS02725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9Q20_RS02750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9Q20_RS02765	COG4771	TonB-dependent receptor
H9Q20_RS02810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H9Q20_RS02840	COG3104	oligopeptide transport
H9Q20_RS02845	COG3104	oligopeptide transport
H9Q20_RS02850	COG3104	oligopeptide transport
H9Q20_RS02860	COG4717	serine-type aminopeptidase activity
H9Q20_RS02865	COG2217	Heavy metal translocating P-type atpase
H9Q20_RS02875	COG1528	Iron-storage protein
H9Q20_RS02880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9Q20_RS02885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9Q20_RS02890	COG0504	CTP synthase activity
H9Q20_RS02910	COG0737	Belongs to the 5'-nucleotidase family
H9Q20_RS02915	COG0737	Belongs to the 5'-nucleotidase family
H9Q20_RS02920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9Q20_RS02935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9Q20_RS02940	COG2354	Protein conserved in bacteria
H9Q20_RS02945	COG1538	Outer membrane efflux protein
H9Q20_RS02955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9Q20_RS02965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9Q20_RS02985	COG0657	acetylesterase activity
H9Q20_RS02985	COG2755	lipolytic protein G-D-S-L family
H9Q20_RS03000	COG1566	PFAM secretion protein HlyD family protein
H9Q20_RS03025	COG1203	CRISPR-associated helicase, Cas3
H9Q20_RS03040	COG1943	Transposase
H9Q20_RS03055	COG1518	maintenance of DNA repeat elements
H9Q20_RS03065	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H9Q20_RS03070	COG1741	Belongs to the pirin family
H9Q20_RS03100	COG3548	integral membrane protein
H9Q20_RS03125	COG0022	dehydrogenase e1 component
H9Q20_RS03145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9Q20_RS03155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9Q20_RS03165	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H9Q20_RS03170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9Q20_RS03175	COG1058	Belongs to the CinA family
H9Q20_RS03175	COG1546	Belongs to the CinA family
H9Q20_RS03190	COG1914	H( )-stimulated, divalent metal cation uptake system
H9Q20_RS03210	COG0300	oxidoreductase activity
H9Q20_RS03215	COG0442	prolyl-tRNA aminoacylation
H9Q20_RS03235	COG2226	methyltransferase
H9Q20_RS03240	COG0116	Belongs to the methyltransferase superfamily
H9Q20_RS03250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9Q20_RS03255	COG0484	heat shock protein binding
H9Q20_RS03270	COG0463	Glycosyl transferase, family 2
H9Q20_RS03280	COG2171	N-acyltransferase activity
H9Q20_RS03295	COG0791	NLP P60 protein
H9Q20_RS03315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9Q20_RS03320	COG1968	undecaprenyl-diphosphatase activity
H9Q20_RS03330	COG2177	Part of the ABC transporter FtsEX involved in
H9Q20_RS03335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9Q20_RS03345	COG0105	UTP biosynthetic process
H9Q20_RS03350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9Q20_RS03355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9Q20_RS03375	COG4935	Belongs to the peptidase S8 family
H9Q20_RS03375	COG2234	aminopeptidase activity
H9Q20_RS03380	COG0513	Belongs to the DEAD box helicase family
H9Q20_RS03385	COG1007	ATP synthesis coupled electron transport
H9Q20_RS03390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9Q20_RS03395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9Q20_RS03410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9Q20_RS03415	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H9Q20_RS03420	COG1034	ATP synthesis coupled electron transport
H9Q20_RS03430	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H9Q20_RS03435	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H9Q20_RS03440	COG0649	NAD binding
H9Q20_RS03445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9Q20_RS03450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9Q20_RS03455	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9Q20_RS03470	COG1739	Uncharacterized protein family UPF0029
H9Q20_RS03475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9Q20_RS03475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9Q20_RS03485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9Q20_RS03490	COG2356	endonuclease I
H9Q20_RS03500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9Q20_RS03505	COG0346	lactoylglutathione lyase activity
H9Q20_RS03530	COG1002	Type II restriction enzyme, methylase subunits
H9Q20_RS03540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9Q20_RS03550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9Q20_RS03565	COG0488	(ABC) transporter
H9Q20_RS03590	COG0464	growth
H9Q20_RS03615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9Q20_RS03650	COG0045	succinate-CoA ligase (ADP-forming) activity
H9Q20_RS03685	COG4574	serine-type endopeptidase inhibitor activity
H9Q20_RS03750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9Q20_RS03760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9Q20_RS03770	COG1490	D-aminoacyl-tRNA deacylase activity
H9Q20_RS03790	COG1012	belongs to the aldehyde dehydrogenase family
H9Q20_RS03790	COG2030	dehydratase
H9Q20_RS03800	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9Q20_RS03805	COG1024	Enoyl-CoA hydratase
H9Q20_RS03810	COG2151	metal-sulfur cluster biosynthetic enzyme
H9Q20_RS03820	COG3460	Phenylacetate-CoA oxygenase
H9Q20_RS03825	COG3396	Phenylacetate-CoA oxygenase
H9Q20_RS03835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9Q20_RS03850	COG0542	response to heat
H9Q20_RS03880	COG1028	Short-chain dehydrogenase reductase Sdr
H9Q20_RS03885	COG0612	Peptidase, M16
H9Q20_RS03890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9Q20_RS03900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H9Q20_RS03915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9Q20_RS03940	COG0813	purine-nucleoside phosphorylase activity
H9Q20_RS03950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9Q20_RS03955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9Q20_RS03965	COG1522	sequence-specific DNA binding
H9Q20_RS03975	COG1959	2 iron, 2 sulfur cluster binding
H9Q20_RS03980	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H9Q20_RS03985	COG1074	ATP-dependent DNA helicase activity
H9Q20_RS04020	COG0438	transferase activity, transferring glycosyl groups
H9Q20_RS04025	COG1472	Belongs to the glycosyl hydrolase 3 family
H9Q20_RS04045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9Q20_RS04050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9Q20_RS04060	COG0252	asparaginase activity
H9Q20_RS04090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9Q20_RS04095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9Q20_RS04105	COG0297	glycogen (starch) synthase activity
H9Q20_RS04120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9Q20_RS04140	COG0488	(ABC) transporter
H9Q20_RS04170	COG1741	Belongs to the pirin family
H9Q20_RS04190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9Q20_RS04195	COG0720	synthase
H9Q20_RS04200	COG1040	competence protein
H9Q20_RS04205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9Q20_RS04210	COG1160	GTP binding
H9Q20_RS04220	COG4654	Cytochrome c, class I
H9Q20_RS04255	COG1131	(ABC) transporter
H9Q20_RS04265	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H9Q20_RS04280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9Q20_RS04285	COG0248	Ppx GppA phosphatase
H9Q20_RS04290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9Q20_RS04310	COG0010	Belongs to the arginase family
H9Q20_RS04330	COG1301	dicarboxylic acid transport
H9Q20_RS04350	COG3537	Alpha-1,2-mannosidase
H9Q20_RS04365	COG0489	protein tyrosine kinase activity
H9Q20_RS04385	COG2096	Adenosyltransferase
H9Q20_RS04390	COG1137	ATPase activity
H9Q20_RS04395	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
H9Q20_RS04400	COG2732	(Barnase) inhibitor
H9Q20_RS04410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9Q20_RS04430	COG0626	cystathionine gamma-synthase activity
H9Q20_RS04440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9Q20_RS04445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9Q20_RS04445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9Q20_RS04460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9Q20_RS04465	COG1322	Protein conserved in bacteria
H9Q20_RS04470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9Q20_RS04500	COG0826	peptidase U32
H9Q20_RS04505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9Q20_RS04515	COG0251	oxidation-reduction process
H9Q20_RS04525	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9Q20_RS04535	COG0268	Binds directly to 16S ribosomal RNA
H9Q20_RS04550	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9Q20_RS04565	COG0791	NLP P60 protein
H9Q20_RS04565	COG1388	LysM domain
H9Q20_RS04570	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H9Q20_RS04590	COG4771	TonB-dependent receptor
H9Q20_RS04600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9Q20_RS04605	COG0195	Participates in both transcription termination and antitermination
H9Q20_RS04610	COG0779	Required for maturation of 30S ribosomal subunits
H9Q20_RS04660	COG1216	Glycosyl transferase, family 2
H9Q20_RS04665	COG1215	transferase activity, transferring glycosyl groups
H9Q20_RS04675	COG1215	transferase activity, transferring glycosyl groups
H9Q20_RS04680	COG0463	Glycosyl transferase, family 2
H9Q20_RS04685	COG0367	asparagine synthase
H9Q20_RS04695	COG0463	Glycosyl transferase, family 2
H9Q20_RS04705	COG0463	Glycosyl transferase, family 2
H9Q20_RS04720	COG3394	polysaccharide catabolic process
H9Q20_RS04775	COG0288	reversible hydration of carbon dioxide
H9Q20_RS04785	COG0193	aminoacyl-tRNA hydrolase activity
H9Q20_RS04805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9Q20_RS04825	COG2076	Multidrug Resistance protein
H9Q20_RS04840	COG1862	Preprotein translocase
H9Q20_RS04850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9Q20_RS04855	COG1132	(ABC) transporter
H9Q20_RS04870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H9Q20_RS04905	COG0495	leucyl-tRNA aminoacylation
H9Q20_RS04935	COG1519	Transferase
H9Q20_RS04935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9Q20_RS04975	COG0037	tRNA processing
H9Q20_RS05025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H9Q20_RS05030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H9Q20_RS05035	COG2884	Cell division ATP-binding protein ftsE
H9Q20_RS05040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9Q20_RS05045	COG5000	phosphorelay sensor kinase activity
H9Q20_RS05050	COG0307	riboflavin synthase, alpha
H9Q20_RS05070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9Q20_RS05080	COG2234	aminopeptidase activity
H9Q20_RS05085	COG0825	malonyl-CoA metabolic process
H9Q20_RS05090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9Q20_RS05100	COG1216	Glycosyl transferase, family 2
H9Q20_RS05135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9Q20_RS05140	COG0439	Biotin carboxylase
H9Q20_RS05145	COG0511	ligase activity, forming carbon-carbon bonds
H9Q20_RS05150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9Q20_RS05160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9Q20_RS05165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9Q20_RS05165	COG1703	isobutyryl-CoA mutase activity
H9Q20_RS05165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9Q20_RS05175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9Q20_RS05185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9Q20_RS05205	COG0254	rRNA binding
H9Q20_RS05230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9Q20_RS05235	COG0300	oxidoreductase activity
H9Q20_RS05250	COG0052	Belongs to the universal ribosomal protein uS2 family
H9Q20_RS05255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9Q20_RS05260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9Q20_RS05265	COG1695	Transcriptional regulator
H9Q20_RS05275	COG0517	IMP dehydrogenase activity
H9Q20_RS05275	COG0516	GMP reductase activity
H9Q20_RS05285	COG0793	Belongs to the peptidase S41A family
H9Q20_RS05290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9Q20_RS05295	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9Q20_RS05305	COG4948	Mandelate Racemase Muconate Lactonizing
H9Q20_RS05310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9Q20_RS05315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9Q20_RS05325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9Q20_RS05330	COG0180	Tryptophanyl-tRNA synthetase
H9Q20_RS05335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9Q20_RS05340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9Q20_RS05345	COG3033	Beta-eliminating lyase
H9Q20_RS05355	COG2733	membrane
H9Q20_RS05360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9Q20_RS05375	COG0811	peptide transport
H9Q20_RS05400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9Q20_RS05400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9Q20_RS05410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9Q20_RS05420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H9Q20_RS05420	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H9Q20_RS05425	COG2081	HI0933 family
H9Q20_RS05445	COG0423	glycine-tRNA ligase activity
H9Q20_RS05455	COG0167	dihydroorotate dehydrogenase activity
H9Q20_RS05460	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H9Q20_RS05495	COG0758	DNA mediated transformation
H9Q20_RS05505	COG3530	Putative quorum-sensing-regulated virulence factor
H9Q20_RS05515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9Q20_RS05540	COG0594	ribonuclease P activity
H9Q20_RS05545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9Q20_RS05550	COG0084	hydrolase, TatD family'
H9Q20_RS05555	COG1309	transcriptional regulator
H9Q20_RS05580	COG0497	DNA recombination
H9Q20_RS05595	COG0791	NLP P60 protein
H9Q20_RS05625	COG1770	oligopeptidase
H9Q20_RS05635	COG1595	DNA-templated transcription, initiation
H9Q20_RS05640	COG0546	phosphoglycolate phosphatase activity
H9Q20_RS05675	COG0564	pseudouridine synthase activity
H9Q20_RS05685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9Q20_RS05695	COG2217	Heavy metal translocating P-type atpase
H9Q20_RS05700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9Q20_RS05705	COG2715	membrane protein required for spore maturation
H9Q20_RS05730	COG2151	metal-sulfur cluster biosynthetic enzyme
H9Q20_RS05740	COG0482	sulfurtransferase activity
H9Q20_RS05745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9Q20_RS05750	COG1607	acyl-coa hydrolase
H9Q20_RS05765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9Q20_RS05775	COG0606	chelatase, subunit chli
H9Q20_RS05780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9Q20_RS05790	COG2032	superoxide dismutase activity
H9Q20_RS05795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9Q20_RS05795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9Q20_RS05805	COG2166	iron-sulfur cluster assembly
H9Q20_RS05890	COG1132	(ABC) transporter
H9Q20_RS05915	COG1959	2 iron, 2 sulfur cluster binding
H9Q20_RS05920	COG2151	metal-sulfur cluster biosynthetic enzyme
H9Q20_RS05950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9Q20_RS05955	COG2153	protein acetylation
H9Q20_RS05990	COG0750	zinc metalloprotease
H9Q20_RS06000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9Q20_RS06005	COG3591	Belongs to the peptidase S1B family
H9Q20_RS06020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9Q20_RS06030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9Q20_RS06040	COG0556	nucleotide-excision repair
H9Q20_RS06055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9Q20_RS06065	COG0542	response to heat
H9Q20_RS06075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9Q20_RS06080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9Q20_RS06180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H9Q20_RS06210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9Q20_RS06220	COG1610	YqeY-like protein
H9Q20_RS06225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9Q20_RS06240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9Q20_RS06245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9Q20_RS06255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9Q20_RS06260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9Q20_RS06265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9Q20_RS06270	COG0768	penicillin binding
H9Q20_RS06280	COG0275	rRNA processing
H9Q20_RS06285	COG2001	Belongs to the MraZ family
H9Q20_RS06290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H9Q20_RS06300	COG1611	Belongs to the LOG family
H9Q20_RS06305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9Q20_RS06310	COG1660	Displays ATPase and GTPase activities
H9Q20_RS06330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9Q20_RS06355	COG0772	Belongs to the SEDS family
H9Q20_RS06370	COG1214	PFAM Peptidase M22, glycoprotease
H9Q20_RS06375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9Q20_RS06385	COG0424	maF-like protein
H9Q20_RS06390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H9Q20_RS06400	COG1595	DNA-templated transcription, initiation
H9Q20_RS06475	COG0719	Fe-S assembly protein
H9Q20_RS06480	COG0396	ATPase activity
H9Q20_RS06485	COG0719	Fe-S assembly protein
H9Q20_RS06490	COG0316	Belongs to the HesB IscA family
H9Q20_RS06510	COG4221	oxidoreductase activity
H9Q20_RS06520	COG0792	nuclease activity
H9Q20_RS06525	COG1619	proteins homologs of microcin C7 resistance protein MccF
H9Q20_RS06535	COG0557	exoribonuclease II activity
H9Q20_RS06540	COG0698	ribose 5-phosphate isomerase
H9Q20_RS06545	COG0126	phosphoglycerate kinase activity
H9Q20_RS06560	COG0445	tRNA wobble uridine modification
H9Q20_RS06565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9Q20_RS06575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9Q20_RS06580	COG1435	thymidine kinase activity
H9Q20_RS06590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9Q20_RS06595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9Q20_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
H9Q20_RS06605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9Q20_RS06630	COG0481	GTPase activity
H9Q20_RS06650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9Q20_RS06655	COG0602	queuosine metabolic process
H9Q20_RS06665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9Q20_RS06695	COG2321	neutral zinc metallopeptidase
H9Q20_RS06700	COG1368	sulfuric ester hydrolase activity
H9Q20_RS06705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9Q20_RS06730	COG0653	protein targeting
H9Q20_RS06750	COG1505	serine-type exopeptidase activity
H9Q20_RS06770	COG0457	Tetratricopeptide repeat
H9Q20_RS06770	COG0705	Rhomboid family
H9Q20_RS06775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9Q20_RS06800	COG0305	Participates in initiation and elongation during chromosome replication
H9Q20_RS06805	COG0328	RNA-DNA hybrid ribonuclease activity
H9Q20_RS06815	COG1703	isobutyryl-CoA mutase activity
H9Q20_RS06825	COG4783	chaperone-mediated protein folding
H9Q20_RS06850	COG3474	cytochrome
H9Q20_RS06855	COG0437	4 iron, 4 sulfur cluster binding
H9Q20_RS06870	COG3258	Cytochrome c
H9Q20_RS06885	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9Q20_RS06890	COG1940	carbohydrate kinase activity
H9Q20_RS06900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9Q20_RS06910	COG0181	hydroxymethylbilane synthase activity
H9Q20_RS06915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H9Q20_RS06935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H9Q20_RS06940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9Q20_RS06950	COG1774	PSP1 C-terminal conserved region
H9Q20_RS06965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9Q20_RS06970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9Q20_RS06975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9Q20_RS06985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H9Q20_RS06990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9Q20_RS07020	COG0500	methyltransferase
H9Q20_RS07030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9Q20_RS07030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9Q20_RS07065	COG0433	COG0433 Predicted ATPase
H9Q20_RS07070	COG2176	DNA-directed DNA polymerase activity
H9Q20_RS07080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9Q20_RS07135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9Q20_RS07155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9Q20_RS07160	COG2181	nitrate reductase activity
H9Q20_RS07160	COG0247	lactate metabolic process
H9Q20_RS07165	COG0247	lactate metabolic process
H9Q20_RS07165	COG2181	nitrate reductase activity
H9Q20_RS07175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9Q20_RS07190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9Q20_RS07220	COG3118	belongs to the thioredoxin family
H9Q20_RS07230	COG0688	phosphatidylethanolamine metabolic process
H9Q20_RS07235	COG4589	Belongs to the CDS family
H9Q20_RS07245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9Q20_RS07250	COG0799	negative regulation of ribosome biogenesis
H9Q20_RS07255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H9Q20_RS07255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H9Q20_RS07265	COG0343	queuine tRNA-ribosyltransferase activity
H9Q20_RS07275	COG1216	Glycosyl transferase, family 2
H9Q20_RS07290	COG0778	Nitroreductase
H9Q20_RS07315	COG1216	Glycosyl transferase, family 2
H9Q20_RS07315	COG1442	glycosyl transferase family 8
H9Q20_RS07325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9Q20_RS07345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9Q20_RS07450	COG1522	sequence-specific DNA binding
H9Q20_RS07460	COG0336	Belongs to the RNA methyltransferase TrmD family
H9Q20_RS07485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9Q20_RS07515	COG4974	Belongs to the 'phage' integrase family
H9Q20_RS07525	COG1024	Enoyl-CoA hydratase
H9Q20_RS07530	COG0753	catalase activity
H9Q20_RS07535	COG0583	DNA-binding transcription factor activity
H9Q20_RS07540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9Q20_RS07555	COG1408	metallophosphoesterase
H9Q20_RS07560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9Q20_RS07580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9Q20_RS07590	COG2202	Pas domain
H9Q20_RS07590	COG2205	protein histidine kinase activity
H9Q20_RS07595	COG2197	response regulator
H9Q20_RS07600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9Q20_RS07630	COG1525	nuclease
H9Q20_RS07640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9Q20_RS07685	COG0237	dephospho-CoA kinase activity
H9Q20_RS07690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9Q20_RS07695	COG2808	Putative FMN-binding domain
H9Q20_RS07700	COG2255	four-way junction helicase activity
H9Q20_RS07705	COG1228	amidohydrolase
H9Q20_RS07715	COG1012	belongs to the aldehyde dehydrogenase family
H9Q20_RS07730	COG0571	ribonuclease III activity
H9Q20_RS07735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9Q20_RS07740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9Q20_RS07780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9Q20_RS07820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9Q20_RS07840	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9Q20_RS07845	COG0081	regulation of translation
H9Q20_RS07850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9Q20_RS07855	COG0222	ribosome binding
H9Q20_RS07860	COG0085	RNA polymerase activity
H9Q20_RS07865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9Q20_RS07875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9Q20_RS07880	COG0706	membrane insertase activity
H9Q20_RS07890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9Q20_RS07895	COG4771	TonB-dependent receptor
H9Q20_RS07905	COG0018	arginyl-trna synthetase
H9Q20_RS07920	COG0101	tRNA pseudouridine synthase activity
H9Q20_RS07925	COG1663	tetraacyldisaccharide 4'-kinase activity
H9Q20_RS07930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9Q20_RS07945	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9Q20_RS07950	COG0658	competence protein
H9Q20_RS07950	COG2333	competence protein COMEC
H9Q20_RS07960	COG1053	succinate dehydrogenase
H9Q20_RS07970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9Q20_RS07990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9Q20_RS08025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9Q20_RS08030	COG0459	protein refolding
H9Q20_RS08035	COG1047	Peptidyl-prolyl cis-trans
H9Q20_RS08105	COG4771	TonB-dependent receptor
H9Q20_RS08120	COG0124	histidyl-tRNA synthetase
H9Q20_RS08130	COG1217	gtp-binding protein TYPA
H9Q20_RS08135	COG1132	(ABC) transporter
H9Q20_RS08160	COG0783	Belongs to the Dps family
H9Q20_RS08170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9Q20_RS08175	COG0049	tRNA binding
H9Q20_RS08180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9Q20_RS08185	COG0051	transcription antitermination factor activity, RNA binding
H9Q20_RS08200	COG0051	transcription antitermination factor activity, RNA binding
H9Q20_RS08220	COG2801	Transposase and inactivated derivatives
H9Q20_RS08235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9Q20_RS08240	COG0088	Forms part of the polypeptide exit tunnel
H9Q20_RS08245	COG0089	rRNA binding
H9Q20_RS08250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9Q20_RS08255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9Q20_RS08260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9Q20_RS08265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9Q20_RS08270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9Q20_RS08275	COG0255	Belongs to the universal ribosomal protein uL29 family
H9Q20_RS08280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9Q20_RS08285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9Q20_RS08295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9Q20_RS08300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9Q20_RS08305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9Q20_RS08310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9Q20_RS08315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9Q20_RS08320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9Q20_RS08325	COG1841	ribosomal large subunit assembly
H9Q20_RS08330	COG0200	Binds to the 23S rRNA
H9Q20_RS08340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9Q20_RS08345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9Q20_RS08350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9Q20_RS08355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9Q20_RS08360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9Q20_RS08365	COG0202	RNA polymerase activity
H9Q20_RS08370	COG0203	ribosomal protein L17
H9Q20_RS08385	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9Q20_RS08450	COG1446	asparaginase
H9Q20_RS08485	COG1187	pseudouridine synthase activity
H9Q20_RS08505	COG0714	Associated with various cellular activities
H9Q20_RS08540	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H9Q20_RS08550	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9Q20_RS08555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H9Q20_RS08555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9Q20_RS08565	COG0488	(ABC) transporter
H9Q20_RS08570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9Q20_RS08575	COG2885	chlorophyll binding
H9Q20_RS08580	COG0217	transcriptional regulatory protein
H9Q20_RS08595	COG0302	gtp cyclohydrolase
H9Q20_RS08610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9Q20_RS08620	COG0148	phosphopyruvate hydratase activity
H9Q20_RS08665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9Q20_RS08685	COG1410	methionine synthase
H9Q20_RS08685	COG0646	methionine synthase
H9Q20_RS08690	COG0527	aspartate kinase activity
H9Q20_RS08690	COG0460	homoserine dehydrogenase
H9Q20_RS08695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9Q20_RS08700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9Q20_RS08710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9Q20_RS08745	COG0326	Molecular chaperone. Has ATPase activity
H9Q20_RS08755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9Q20_RS08760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9Q20_RS08765	COG0205	6-phosphofructokinase activity
H9Q20_RS08770	COG0632	four-way junction helicase activity
H9Q20_RS08780	COG0509	glycine decarboxylation via glycine cleavage system
H9Q20_RS08845	COG0513	Belongs to the DEAD box helicase family
H9Q20_RS08875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9Q20_RS08890	COG1216	Glycosyl transferase, family 2
H9Q20_RS08890	COG0463	Glycosyl transferase, family 2
H9Q20_RS08895	COG0009	L-threonylcarbamoyladenylate synthase
H9Q20_RS08900	COG0039	L-malate dehydrogenase activity
H9Q20_RS08910	COG0113	porphobilinogen synthase activity
H9Q20_RS08920	COG4152	abc transporter atp-binding protein
H9Q20_RS08925	COG1668	transmembrane transport
H9Q20_RS08930	COG1078	dGTPase activity
H9Q20_RS08935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9Q20_RS08940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9Q20_RS08940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H9Q20_RS08950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9Q20_RS08955	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9Q20_RS08960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9Q20_RS08970	COG0745	RESPONSE REGULATOR receiver
H9Q20_RS08975	COG0754	glutathionylspermidine amidase activity
H9Q20_RS08985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9Q20_RS09045	COG3548	integral membrane protein
H9Q20_RS09050	COG0708	Exodeoxyribonuclease III
H9Q20_RS09055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9Q20_RS09055	COG0284	orotidine-5'-phosphate decarboxylase activity
H9Q20_RS09060	COG3339	Conserved Protein
H9Q20_RS09065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9Q20_RS09075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9Q20_RS09080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9Q20_RS09085	COG0739	heme binding
H9Q20_RS09090	COG0612	Peptidase, M16
H9Q20_RS09095	COG0612	Peptidase, M16
H9Q20_RS09100	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9Q20_RS09105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9Q20_RS09110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9Q20_RS09120	COG0552	protein localization to endoplasmic reticulum
H9Q20_RS09130	COG0616	signal peptide processing
H9Q20_RS09145	COG2885	chlorophyll binding
H9Q20_RS09155	COG0339	signal peptide processing
H9Q20_RS09160	COG3012	SEC-C Motif Domain Protein
H9Q20_RS09165	COG4628	conserved protein (DUF2132)
H9Q20_RS09185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9Q20_RS09185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9Q20_RS09190	COG2824	Alkylphosphonate utilization operon protein PhnA
H9Q20_RS09195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9Q20_RS09215	COG0387	Pfam Sodium calcium exchanger
H9Q20_RS09225	COG0629	single-stranded DNA binding
H9Q20_RS09230	COG0488	(ABC) transporter
H9Q20_RS09240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9Q20_RS09250	COG2010	Cytochrome c
H9Q20_RS09255	COG3256	nitric oxide reductase
H9Q20_RS09260	COG0714	Associated with various cellular activities
H9Q20_RS09265	COG4548	von Willebrand factor, type A
H9Q20_RS09270	COG1845	cytochrome c oxidase, subunit III
H9Q20_RS09295	COG0302	gtp cyclohydrolase
H9Q20_RS09300	COG0215	cysteine-tRNA ligase activity
H9Q20_RS09310	COG4145	pantothenate transmembrane transporter activity
H9Q20_RS09320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H9Q20_RS09330	COG0436	Aminotransferase
H9Q20_RS09335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9Q20_RS09360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H9Q20_RS09375	COG1629	transport
H9Q20_RS09405	COG2885	chlorophyll binding
H9Q20_RS09415	COG1678	Uncharacterized ACR, COG1678
H9Q20_RS09420	COG0259	pyridoxamine-phosphate oxidase activity
H9Q20_RS09425	COG0514	ATP-dependent DNA helicase (RecQ)
H9Q20_RS09440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9Q20_RS09475	COG2176	DNA-directed DNA polymerase activity
H9Q20_RS09475	COG5002	protein histidine kinase activity
H9Q20_RS09480	COG1183	phosphatidylcholine synthase activity
H9Q20_RS09485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9Q20_RS09510	COG0443	Heat shock 70 kDa protein
H9Q20_RS09520	COG4974	Belongs to the 'phage' integrase family
H9Q20_RS09555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H9Q20_RS09570	COG1401	restriction endodeoxyribonuclease activity
H9Q20_RS09590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9Q20_RS09615	COG3550	peptidyl-serine autophosphorylation
H9Q20_RS09620	COG3655	Transcriptional regulator
H9Q20_RS09650	COG3023	N-Acetylmuramoyl-L-alanine amidase
H9Q20_RS09665	COG1215	transferase activity, transferring glycosyl groups
H9Q20_RS09695	COG0612	Peptidase, M16
H9Q20_RS09705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9Q20_RS09710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9Q20_RS09720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9Q20_RS09745	COG0525	valine-tRNA ligase activity
H9Q20_RS09755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9Q20_RS09765	COG2226	methyltransferase
H9Q20_RS09770	COG3189	MarR family transcriptional regulator
H9Q20_RS09775	COG0069	glutamate synthase activity
H9Q20_RS09780	COG1418	mRNA catabolic process
H9Q20_RS09800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9Q20_RS09805	COG2137	regulation of response to DNA damage stimulus
H9Q20_RS09850	COG0438	transferase activity, transferring glycosyl groups
H9Q20_RS09855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9Q20_RS09870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H9Q20_RS09905	COG4804	nuclease activity
H9Q20_RS09910	COG1086	Polysaccharide biosynthesis protein
H9Q20_RS09955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9Q20_RS09980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9Q20_RS09985	COG1333	cytochrome c biogenesis protein
H9Q20_RS09985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9Q20_RS10000	COG1674	ftsk spoiiie
H9Q20_RS10020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9Q20_RS10030	COG4948	Mandelate Racemase Muconate Lactonizing
H9Q20_RS10035	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H9Q20_RS10040	COG0527	aspartate kinase activity
H9Q20_RS10075	COG0295	cytidine deaminase activity
H9Q20_RS10095	COG0617	tRNA 3'-terminal CCA addition
H9Q20_RS10095	COG0517	IMP dehydrogenase activity
H9Q20_RS10095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H9Q20_RS10100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9Q20_RS10115	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9Q20_RS10120	COG0633	Ferredoxin
H9Q20_RS10125	COG0492	ferredoxin-NADP+ reductase activity
H9Q20_RS10135	COG3590	peptidase
H9Q20_RS10150	COG0339	signal peptide processing
H9Q20_RS10165	COG1704	LemA family
H9Q20_RS10170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9Q20_RS10185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9Q20_RS10190	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9Q20_RS10200	COG0564	pseudouridine synthase activity
H9Q20_RS10210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9Q20_RS10225	COG0242	peptide deformylase activity
H9Q20_RS10230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9Q20_RS10235	COG0406	alpha-ribazole phosphatase activity
H9Q20_RS10265	COG0116	Belongs to the methyltransferase superfamily
H9Q20_RS10265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9Q20_RS10270	COG3956	TIGRFAM MazG family protein
H9Q20_RS10275	COG3158	transport of potassium into the cell
H9Q20_RS10280	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9Q20_RS10280	COG0022	dehydrogenase e1 component
H9Q20_RS10300	COG0228	four-way junction DNA binding
H9Q20_RS10305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9Q20_RS10310	COG0017	Asparaginyl-tRNA synthetase
H9Q20_RS10320	COG0322	excinuclease ABC activity
H9Q20_RS10325	COG2986	histidine ammonia-lyase
H9Q20_RS10360	COG2353	YceI-like domain
H9Q20_RS10365	COG0823	Involved in the tonB-independent uptake of proteins
H9Q20_RS10365	COG1506	peptidase
H9Q20_RS10385	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H9Q20_RS10395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9Q20_RS10405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9Q20_RS10415	COG1858	cytochrome C peroxidase
H9Q20_RS10435	COG0252	asparaginase activity
H9Q20_RS10450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9Q20_RS10470	COG0084	hydrolase, TatD family'
H9Q20_RS10485	COG0306	phosphate transporter
H9Q20_RS10500	COG0513	Belongs to the DEAD box helicase family
H9Q20_RS10515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9Q20_RS10520	COG1192	Involved in chromosome partitioning
H9Q20_RS10525	COG1475	DNA binding
H9Q20_RS10535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9Q20_RS10540	COG0681	Belongs to the peptidase S26 family
H9Q20_RS10565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H9Q20_RS10570	COG0277	FAD linked oxidase domain protein
H9Q20_RS10585	COG1104	cysteine desulfurase activity
H9Q20_RS10590	COG3118	belongs to the thioredoxin family
H9Q20_RS10605	COG4974	Belongs to the 'phage' integrase family
H9Q20_RS10625	COG0509	glycine decarboxylation via glycine cleavage system
H9Q20_RS10630	COG0798	PFAM Bile acid sodium symporter
H9Q20_RS10660	COG3781	membrane
H9Q20_RS10670	COG1368	sulfuric ester hydrolase activity
H9Q20_RS10675	COG1285	pathogenesis
H9Q20_RS10680	COG2217	Heavy metal translocating P-type atpase
H9Q20_RS10685	COG0671	phosphoesterase, PA-phosphatase related
H9Q20_RS10690	COG2356	endonuclease I
H9Q20_RS10715	COG2132	Multicopper oxidase
H9Q20_RS10740	COG4206	TonB-dependent receptor
H9Q20_RS10740	COG1629	transport
H9Q20_RS10825	COG0629	single-stranded DNA binding
H9Q20_RS10990	COG0739	heme binding
H9Q20_RS11015	COG0827	DNA restriction-modification system
H9Q20_RS11040	COG0587	DNA-directed DNA polymerase activity
H9Q20_RS11045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9Q20_RS11145	COG1846	Transcriptional regulator
H9Q20_RS11155	COG2132	Multicopper oxidase
H9Q20_RS11175	COG1064	alcohol dehydrogenase
H9Q20_RS11180	COG1064	alcohol dehydrogenase
H9Q20_RS11195	COG0667	Aldo Keto reductase
H9Q20_RS11200	COG0667	Aldo Keto reductase
H9Q20_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
H9Q20_RS11240	COG3609	addiction module antidote protein, CC2985 family
H9Q20_RS11305	COG2274	protein secretion by the type I secretion system
H9Q20_RS11330	COG1131	(ABC) transporter
H9Q20_RS11345	COG2312	Erythromycin esterase
H9Q20_RS11400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9Q20_RS11420	COG0739	heme binding
H9Q20_RS11475	COG0484	heat shock protein binding
H9Q20_RS11515	COG1196	nuclear chromosome segregation
H9Q20_RS11525	COG4974	Belongs to the 'phage' integrase family
H9Q20_RS11530	COG2801	Transposase and inactivated derivatives
H9Q20_RS11550	COG0415	Belongs to the DNA photolyase family
H9Q20_RS11560	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H9Q20_RS11565	COG1090	epimerase
H9Q20_RS11635	COG1876	peptidase activity
H9Q20_RS11720	COG0740	serine-type endopeptidase activity
H9Q20_RS11820	COG3392	D12 class N6 adenine-specific DNA methyltransferase
H9Q20_RS11840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9Q20_RS11855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9Q20_RS11880	COG0640	Transcriptional regulator
H9Q20_RS11895	COG0798	PFAM Bile acid sodium symporter
H9Q20_RS11900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9Q20_RS11920	COG1309	transcriptional regulator
H9Q20_RS11950	COG2801	Transposase and inactivated derivatives
H9Q20_RS11970	COG2197	response regulator
H9Q20_RS12075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9Q20_RS12090	COG0456	acetyltransferase
H9Q20_RS12135	COG3668	Plasmid stabilization system
H9Q20_RS12170	COG1396	sequence-specific DNA binding
H9Q20_RS12170	COG3800	Transcriptional regulator
H9Q20_RS12255	COG0433	COG0433 Predicted ATPase
H9Q20_RS12290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9Q20_RS12295	COG0659	secondary active sulfate transmembrane transporter activity
H9Q20_RS12320	COG2268	Band 7 protein
H9Q20_RS12340	COG4974	Belongs to the 'phage' integrase family
H9Q20_RS12345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9Q20_RS12360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9Q20_RS12365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9Q20_RS12370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9Q20_RS12385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9Q20_RS12390	COG0450	alkyl hydroperoxide reductase
H9Q20_RS12395	COG0436	Aminotransferase
H9Q20_RS12400	COG0357	Ribosomal RNA small subunit methyltransferase G
H9Q20_RS12420	COG1960	acyl-CoA dehydrogenase activity
H9Q20_RS12425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9Q20_RS12435	COG0519	Catalyzes the synthesis of GMP from XMP
H9Q20_RS12445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9Q20_RS12445	COG0321	lipoyl(octanoyl) transferase activity
H9Q20_RS12465	COG2239	Acts as a magnesium transporter
H9Q20_RS12475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9Q20_RS12480	COG1185	polyribonucleotide nucleotidyltransferase activity
H9Q20_RS12485	COG3033	Beta-eliminating lyase
H9Q20_RS12495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9Q20_RS12540	COG1169	isochorismate synthase
H9Q20_RS12545	COG2050	protein possibly involved in aromatic compounds catabolism
H9Q20_RS12565	COG2814	Major facilitator Superfamily
H9Q20_RS12570	COG1193	negative regulation of DNA recombination
H9Q20_RS12590	COG0668	transmembrane transport
H9Q20_RS12595	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9Q20_RS12600	COG2267	carboxylic ester hydrolase activity
H9Q20_RS12620	COG1022	Amp-dependent synthetase and ligase
H9Q20_RS12645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9Q20_RS12650	COG0346	lactoylglutathione lyase activity
H9Q20_RS12660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9Q20_RS12665	COG1363	Peptidase, m42
H9Q20_RS12680	COG0494	nUDIX hydrolase
H9Q20_RS12685	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H9Q20_RS12685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9Q20_RS12690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9Q20_RS12695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9Q20_RS12700	COG0358	DNA primase activity
H9Q20_RS12705	COG0740	serine-type endopeptidase activity
H9Q20_RS12710	COG0149	triose-phosphate isomerase activity
H9Q20_RS12730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9Q20_RS12745	COG1649	PFAM Uncharacterised BCR, COG1649
H9Q20_RS12770	COG0705	Rhomboid family
H9Q20_RS12795	COG0012	GTP binding
H9Q20_RS12810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9Q20_RS12825	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9Q20_RS12845	COG0321	lipoyl(octanoyl) transferase activity
H9Q20_RS12850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9Q20_RS12850	COG0512	Glutamine amidotransferase of anthranilate synthase
H9Q20_RS12870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9Q20_RS12875	COG0187	DNA topoisomerase II activity
H9Q20_RS12910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9Q20_RS12915	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9Q20_RS12940	COG0156	8-amino-7-oxononanoate synthase activity
H9Q20_RS12950	COG1981	membrane
H9Q20_RS12965	COG0233	cytoplasmic translational termination
H9Q20_RS12970	COG0528	UMP kinase activity
H9Q20_RS12980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9Q20_RS13000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9Q20_RS13020	COG1131	(ABC) transporter
H9Q20_RS13035	COG4206	TonB-dependent receptor
H9Q20_RS13040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9Q20_RS13045	COG0183	Belongs to the thiolase family
H9Q20_RS13055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9Q20_RS13075	COG1575	Belongs to the MenA family. Type 1 subfamily
H9Q20_RS13080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H9Q20_RS13115	COG1192	Involved in chromosome partitioning