locus-tag	class	description
AXY_RS00010	COG0592	DNA-directed DNA polymerase activity
AXY_RS00015	COG2501	S4 domain
AXY_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXY_RS00030	COG0187	DNA topoisomerase II activity
AXY_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXY_RS00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AXY_RS00045	COG0517	IMP dehydrogenase activity
AXY_RS00045	COG0516	GMP reductase activity
AXY_RS00055	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AXY_RS00060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXY_RS00065	COG4989	oxidoreductase activity
AXY_RS00080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AXY_RS00085	COG0697	spore germination
AXY_RS00090	COG1388	LysM domain
AXY_RS00090	COG3858	chitin binding
AXY_RS00095	COG0590	tRNA wobble adenosine to inosine editing
AXY_RS00100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AXY_RS00105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AXY_RS00110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXY_RS00130	COG4608	Belongs to the ABC transporter superfamily
AXY_RS00135	COG0601	transmembrane transport
AXY_RS00160	COG3870	Protein conserved in bacteria
AXY_RS00165	COG1728	Protein conserved in bacteria
AXY_RS00170	COG0470	DNA polymerase III
AXY_RS00175	COG1774	PSP1 C-terminal conserved region
AXY_RS00180	COG4467	Involved in initiation control of chromosome replication
AXY_RS00185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AXY_RS00190	COG2827	Endonuclease containing a URI domain
AXY_RS00195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AXY_RS00200	COG2002	toxin-antitoxin pair type II binding
AXY_RS00205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXY_RS00205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXY_RS00210	COG0084	hydrolase, TatD family'
AXY_RS00215	COG3583	domain protein
AXY_RS00215	COG3584	3D domain protein
AXY_RS00220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AXY_RS00225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXY_RS00250	COG4466	Protein conserved in bacteria
AXY_RS00255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXY_RS00260	COG2088	sporulation resulting in formation of a cellular spore
AXY_RS00265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXY_RS00270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXY_RS00275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXY_RS00280	COG0193	aminoacyl-tRNA hydrolase activity
AXY_RS00290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AXY_RS00295	COG2002	toxin-antitoxin pair type II binding
AXY_RS00300	COG2244	polysaccharide biosynthetic process
AXY_RS00305	COG3956	TIGRFAM MazG family protein
AXY_RS00310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AXY_RS00330	COG1098	S1 RNA binding domain
AXY_RS00375	COG1122	ATPase activity
AXY_RS00390	COG2208	phosphoserine phosphatase activity
AXY_RS00395	COG2304	oxidoreductase activity
AXY_RS00400	COG0515	serine threonine protein kinase
AXY_RS00405	COG0037	tRNA processing
AXY_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AXY_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXY_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AXY_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AXY_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXY_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AXY_RS00440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXY_RS00445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AXY_RS00450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXY_RS00455	COG1396	sequence-specific DNA binding
AXY_RS00460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXY_RS00540	COG1307	EDD domain protein, DegV family
AXY_RS00545	COG1285	pathogenesis
AXY_RS00555	COG3880	PFAM UvrB UvrC protein
AXY_RS00560	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AXY_RS00565	COG0542	response to heat
AXY_RS00570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AXY_RS00575	COG4956	integral membrane protein (PIN domain superfamily)
AXY_RS00580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXY_RS00585	COG1045	serine acetyltransferase
AXY_RS00590	COG0215	cysteine-tRNA ligase activity
AXY_RS00595	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AXY_RS00600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXY_RS00605	COG3688	RNA-binding protein containing a PIN domain
AXY_RS00620	COG0250	Participates in transcription elongation, termination and antitermination
AXY_RS00625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXY_RS00630	COG0081	regulation of translation
AXY_RS00635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AXY_RS00640	COG0222	ribosome binding
AXY_RS00645	COG2813	Specifically methylates the guanine in position
AXY_RS00650	COG0085	RNA polymerase activity
AXY_RS00655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXY_RS00660	COG1358	cellular component organization or biogenesis
AXY_RS00665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXY_RS00670	COG0049	tRNA binding
AXY_RS00675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXY_RS00680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXY_RS00685	COG0051	transcription antitermination factor activity, RNA binding
AXY_RS00690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXY_RS00695	COG0088	Forms part of the polypeptide exit tunnel
AXY_RS00700	COG0089	rRNA binding
AXY_RS00705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXY_RS00710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXY_RS00715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXY_RS00720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXY_RS00725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXY_RS00730	COG0255	Belongs to the universal ribosomal protein uL29 family
AXY_RS00735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXY_RS00740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXY_RS00745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXY_RS00750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXY_RS00755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXY_RS00760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXY_RS00765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXY_RS00770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AXY_RS00780	COG1841	ribosomal large subunit assembly
AXY_RS00790	COG0201	protein transport
AXY_RS00795	COG0563	adenylate kinase activity
AXY_RS00805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXY_RS00810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXY_RS00815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXY_RS00820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXY_RS00825	COG0202	RNA polymerase activity
AXY_RS00830	COG0203	ribosomal protein L17
AXY_RS00835	COG1122	ATPase activity
AXY_RS00840	COG1122	ATPase activity
AXY_RS00845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AXY_RS00850	COG0101	tRNA pseudouridine synthase activity
AXY_RS00855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXY_RS00905	COG0577	efflux transmembrane transporter activity
AXY_RS00910	COG1136	(ABC) transporter
AXY_RS00915	COG0515	serine threonine protein kinase
AXY_RS00915	COG2815	serine threonine protein kinase
AXY_RS00930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AXY_RS00940	COG3546	catalase activity
AXY_RS00945	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AXY_RS00950	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXY_RS00955	COG0489	protein tyrosine kinase activity
AXY_RS00965	COG0726	polysaccharide deacetylase
AXY_RS01010	COG4974	Belongs to the 'phage' integrase family
AXY_RS01020	COG1396	sequence-specific DNA binding
AXY_RS01055	COG3617	BRO family, N-terminal domain
AXY_RS01070	COG0629	single-stranded DNA binding
AXY_RS01160	COG0740	serine-type endopeptidase activity
AXY_RS01240	COG4824	toxin secretion phage lysis holin
AXY_RS01265	COG0457	Tetratricopeptide repeat
AXY_RS01265	COG0463	Glycosyl transferase, family 2
AXY_RS01275	COG0463	Glycosyl transferase, family 2
AXY_RS01310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AXY_RS01315	COG4856	YbbR-like protein
AXY_RS01320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXY_RS01325	COG0662	Cupin 2, conserved barrel domain protein
AXY_RS01345	COG4684	Psort location CytoplasmicMembrane, score
AXY_RS01350	COG2860	membrane
AXY_RS01355	COG1473	amidohydrolase
AXY_RS01375	COG2746	aminoglycoside 3-N-acetyltransferase activity
AXY_RS01395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AXY_RS01400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AXY_RS01410	COG0295	cytidine deaminase activity
AXY_RS01415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AXY_RS01425	COG4753	response regulator
AXY_RS01425	COG2207	Transcriptional regulator
AXY_RS01430	COG3507	Belongs to the glycosyl hydrolase 43 family
AXY_RS01435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AXY_RS01450	COG5578	integral membrane protein
AXY_RS01455	COG2972	Histidine kinase
AXY_RS01465	COG4209	transmembrane transport
AXY_RS01470	COG0395	ABC-type sugar transport system, permease component
AXY_RS01480	COG1312	Catalyzes the dehydration of D-mannonate
AXY_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_RS01490	COG0800	Aldolase
AXY_RS01500	COG1904	glucuronate isomerase
AXY_RS01505	COG2115	Belongs to the xylose isomerase family
AXY_RS01510	COG1070	Carbohydrate kinase
AXY_RS01520	COG0351	phosphomethylpyrimidine kinase
AXY_RS01525	COG0083	homoserine kinase activity
AXY_RS01540	COG1012	belongs to the aldehyde dehydrogenase family
AXY_RS01545	COG0346	lactoylglutathione lyase activity
AXY_RS01555	COG4585	Histidine kinase
AXY_RS01560	COG2197	response regulator
AXY_RS01565	COG1131	(ABC) transporter
AXY_RS01580	COG1940	carbohydrate kinase activity
AXY_RS01585	COG1760	l-serine dehydratase
AXY_RS01595	COG1304	FMN binding
AXY_RS01605	COG4120	Belongs to the binding-protein-dependent transport system permease family
AXY_RS01610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXY_RS01615	COG1119	ATPase activity
AXY_RS01620	COG1012	belongs to the aldehyde dehydrogenase family
AXY_RS01620	COG1454	alcohol dehydrogenase
AXY_RS01630	COG1882	Formate acetyltransferase
AXY_RS01635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AXY_RS01640	COG1764	response to oxidative stress
AXY_RS01645	COG0716	FMN binding
AXY_RS01660	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AXY_RS01665	COG0352	thiamine-phosphate diphosphorylase activity
AXY_RS01675	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXY_RS01685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AXY_RS01690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AXY_RS01695	COG1054	Belongs to the UPF0176 family
AXY_RS01710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXY_RS01715	COG0745	RESPONSE REGULATOR receiver
AXY_RS01720	COG5002	protein histidine kinase activity
AXY_RS01720	COG3850	Histidine kinase
AXY_RS01725	COG1217	gtp-binding protein TYPA
AXY_RS01730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AXY_RS01735	COG0573	inorganic phosphate transmembrane transporter activity
AXY_RS01740	COG0581	inorganic phosphate transmembrane transporter activity
AXY_RS01745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXY_RS01750	COG0577	efflux transmembrane transporter activity
AXY_RS01755	COG1136	(ABC) transporter
AXY_RS01760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXY_RS01780	COG1846	Transcriptional regulator
AXY_RS01805	COG0513	Belongs to the DEAD box helicase family
AXY_RS01815	COG0705	Rhomboid family
AXY_RS01820	COG0736	holo-[acyl-carrier-protein] synthase activity
AXY_RS01825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AXY_RS01825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AXY_RS01830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AXY_RS01840	COG0864	Transcriptional regulator
AXY_RS01845	COG2337	Toxic component of a toxin-antitoxin (TA) module
AXY_RS01850	COG1366	Belongs to the anti-sigma-factor antagonist family
AXY_RS01855	COG1366	Belongs to the anti-sigma-factor antagonist family
AXY_RS01860	COG2172	sigma factor antagonist activity
AXY_RS01865	COG2208	phosphoserine phosphatase activity
AXY_RS01870	COG1366	Belongs to the anti-sigma-factor antagonist family
AXY_RS01875	COG2172	sigma factor antagonist activity
AXY_RS01880	COG1191	sigma factor activity
AXY_RS01885	COG2208	phosphoserine phosphatase activity
AXY_RS01890	COG2183	response to ionizing radiation
AXY_RS01895	COG0549	Belongs to the carbamate kinase family
AXY_RS01900	COG3091	SprT-like family
AXY_RS01975	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AXY_RS01980	COG0802	atpase or kinase
AXY_RS01985	COG1214	PFAM Peptidase M22, glycoprotease
AXY_RS01990	COG0456	acetyltransferase
AXY_RS02000	COG0488	(ABC) transporter
AXY_RS02005	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AXY_RS02015	COG1266	CAAX protease self-immunity
AXY_RS02020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXY_RS02025	COG0459	protein refolding
AXY_RS02045	COG2205	protein histidine kinase activity
AXY_RS02045	COG0784	Response regulator, receiver
AXY_RS02050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AXY_RS02065	COG0667	Aldo Keto reductase
AXY_RS02090	COG0673	inositol 2-dehydrogenase activity
AXY_RS02100	COG0673	inositol 2-dehydrogenase activity
AXY_RS02105	COG1082	Xylose isomerase domain protein TIM barrel
AXY_RS02110	COG2202	Pas domain
AXY_RS02110	COG1366	Belongs to the anti-sigma-factor antagonist family
AXY_RS02115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXY_RS02120	COG0714	Associated with various cellular activities
AXY_RS02125	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AXY_RS02130	COG1305	Transglutaminase-like
AXY_RS02140	COG0519	Catalyzes the synthesis of GMP from XMP
AXY_RS02140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXY_RS02145	COG0622	Phosphoesterase
AXY_RS02155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXY_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_RS02165	COG1801	Protein of unknown function DUF72
AXY_RS02180	COG1695	Transcriptional regulator
AXY_RS02195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXY_RS02195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXY_RS02195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_RS02200	COG1105	Belongs to the carbohydrate kinase PfkB family
AXY_RS02205	COG1349	DNA-binding transcription factor activity
AXY_RS02210	COG4213	ABC transporter substrate-binding protein
AXY_RS02220	COG4214	carbohydrate transport
AXY_RS02230	COG2972	Histidine kinase
AXY_RS02235	COG4753	response regulator
AXY_RS02235	COG2207	Transcriptional regulator
AXY_RS02240	COG4213	ABC transporter substrate-binding protein
AXY_RS02245	COG0840	transmembrane signaling receptor activity
AXY_RS02260	COG1131	(ABC) transporter
AXY_RS02275	COG1063	alcohol dehydrogenase
AXY_RS02295	COG2252	PERMEase
AXY_RS02305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AXY_RS02310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AXY_RS02315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AXY_RS02320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXY_RS02325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXY_RS02330	COG0047	phosphoribosylformylglycinamidine synthase activity
AXY_RS02335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXY_RS02340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AXY_RS02345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXY_RS02350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AXY_RS02355	COG0138	bifunctional purine biosynthesis protein purh
AXY_RS02360	COG0151	Belongs to the GarS family
AXY_RS02365	COG1131	(ABC) transporter
AXY_RS02370	COG4555	ABC transporter
AXY_RS02380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXY_RS02390	COG1470	cell adhesion involved in biofilm formation
AXY_RS02395	COG4496	protein, YerC YecD
AXY_RS02400	COG0673	inositol 2-dehydrogenase activity
AXY_RS02405	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AXY_RS02410	COG0210	DNA helicase
AXY_RS02415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXY_RS02420	COG4851	CamS sex pheromone cAM373 precursor
AXY_RS02425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXY_RS02430	COG0154	amidase activity
AXY_RS02435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXY_RS02440	COG1597	lipid kinase activity
AXY_RS02445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXY_RS02460	COG3620	sequence-specific DNA binding
AXY_RS02480	COG0500	methyltransferase
AXY_RS02510	COG0798	PFAM Bile acid sodium symporter
AXY_RS02550	COG0745	RESPONSE REGULATOR receiver
AXY_RS02565	COG2205	protein histidine kinase activity
AXY_RS02600	COG0745	RESPONSE REGULATOR receiver
AXY_RS02605	COG0642	Histidine kinase
AXY_RS02610	COG1136	(ABC) transporter
AXY_RS02615	COG0577	efflux transmembrane transporter activity
AXY_RS02635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AXY_RS02640	COG1116	anion transmembrane transporter activity
AXY_RS02645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXY_RS02650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXY_RS02720	COG3708	Transcriptional regulator
AXY_RS02720	COG2207	Transcriptional regulator
AXY_RS02730	COG2205	protein histidine kinase activity
AXY_RS02735	COG1595	DNA-templated transcription, initiation
AXY_RS02740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXY_RS02745	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AXY_RS02785	COG1269	ATP hydrolysis coupled proton transport
AXY_RS02805	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AXY_RS02815	COG1394	ATPase activity, coupled to movement of substances
AXY_RS02825	COG0583	DNA-binding transcription factor activity
AXY_RS02835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXY_RS02845	COG1733	regulation of RNA biosynthetic process
AXY_RS02850	COG2514	catechol 2,3-dioxygenase activity
AXY_RS02860	COG2239	Acts as a magnesium transporter
AXY_RS02865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_RS02865	COG2190	(PTS) system
AXY_RS02865	COG1263	PTS System
AXY_RS02870	COG2723	6-phospho-beta-galactosidase activity
AXY_RS02880	COG3682	Transcriptional regulator
AXY_RS02885	COG2608	mercury ion transmembrane transporter activity
AXY_RS02895	COG1253	flavin adenine dinucleotide binding
AXY_RS02960	COG3385	transposase activity
AXY_RS02980	COG3250	beta-galactosidase activity
AXY_RS02990	COG0840	transmembrane signaling receptor activity
AXY_RS03000	COG2918	glutathione biosynthetic process
AXY_RS03020	COG1132	(ABC) transporter
AXY_RS03025	COG1132	(ABC) transporter
AXY_RS03035	COG2223	nitrite transmembrane transporter activity
AXY_RS03060	COG0714	Associated with various cellular activities
AXY_RS03080	COG2848	UPF0210 protein
AXY_RS03090	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AXY_RS03095	COG1063	alcohol dehydrogenase
AXY_RS03100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AXY_RS03105	COG0647	UMP catabolic process
AXY_RS03115	COG2190	(PTS) system
AXY_RS03120	COG1077	Cell shape determining protein MreB Mrl
AXY_RS03140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXY_RS03150	COG1295	ribonuclease BN
AXY_RS03155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXY_RS03160	COG0765	amino acid transport
AXY_RS03170	COG2801	Transposase and inactivated derivatives
AXY_RS03175	COG0477	Major facilitator Superfamily
AXY_RS03185	COG0668	transmembrane transport
AXY_RS03195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AXY_RS03210	COG0542	response to heat
AXY_RS03220	COG1131	(ABC) transporter
AXY_RS03230	COG5658	integral membrane protein
AXY_RS03235	COG0640	Transcriptional regulator
AXY_RS03240	COG0488	(ABC) transporter
AXY_RS03250	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_RS03255	COG0840	transmembrane signaling receptor activity
AXY_RS03260	COG4844	belongs to the
AXY_RS03270	COG2137	regulation of response to DNA damage stimulus
AXY_RS03280	COG1988	membrane-bound metal-dependent
AXY_RS03285	COG1194	a g-specific adenine glycosylase
AXY_RS03295	COG3557	Belongs to the UPF0374 family
AXY_RS03300	COG4129	membrane
AXY_RS03310	COG2096	Adenosyltransferase
AXY_RS03315	COG0735	belongs to the Fur family
AXY_RS03450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXY_RS03455	COG0346	lactoylglutathione lyase activity
AXY_RS03470	COG0745	RESPONSE REGULATOR receiver
AXY_RS03475	COG2205	protein histidine kinase activity
AXY_RS03480	COG1136	(ABC) transporter
AXY_RS03485	COG0577	efflux transmembrane transporter activity
AXY_RS03490	COG0745	RESPONSE REGULATOR receiver
AXY_RS03495	COG5002	protein histidine kinase activity
AXY_RS03500	COG2738	Putative neutral zinc metallopeptidase
AXY_RS03505	COG1334	flagellar protein FlaG
AXY_RS03510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AXY_RS03515	COG1516	flagellar protein fliS
AXY_RS03525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AXY_RS03540	COG4214	carbohydrate transport
AXY_RS03545	COG0653	protein targeting
AXY_RS03550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXY_RS03555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AXY_RS03560	COG2884	Cell division ATP-binding protein ftsE
AXY_RS03565	COG2177	Part of the ABC transporter FtsEX involved in
AXY_RS03570	COG0739	heme binding
AXY_RS03575	COG0793	Belongs to the peptidase S41A family
AXY_RS03575	COG3409	Peptidoglycan-binding domain 1 protein
AXY_RS03580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXY_RS03590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AXY_RS03595	COG0556	nucleotide-excision repair
AXY_RS03600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXY_RS03605	COG1983	PspC domain protein
AXY_RS03610	COG1950	PFAM Membrane protein of
AXY_RS03625	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AXY_RS03630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AXY_RS03635	COG0546	phosphoglycolate phosphatase activity
AXY_RS03640	COG0110	maltose O-acetyltransferase activity
AXY_RS03645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AXY_RS03655	COG0492	ferredoxin-NADP+ reductase activity
AXY_RS03665	COG1486	melibiose metabolic process
AXY_RS03690	COG1051	belongs to the nudix hydrolase family
AXY_RS03695	COG1660	Displays ATPase and GTPase activities
AXY_RS03700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AXY_RS03705	COG1481	regulation of sporulation
AXY_RS03710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_RS03730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXY_RS03735	COG3711	transcriptional antiterminator
AXY_RS03740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_RS03740	COG2190	(PTS) system
AXY_RS03740	COG1263	PTS System
AXY_RS03785	COG2197	response regulator
AXY_RS03790	COG4152	abc transporter atp-binding protein
AXY_RS03795	COG1668	transmembrane transport
AXY_RS03800	COG0420	3'-5' exonuclease activity
AXY_RS03815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXY_RS03830	COG0537	adenosine 5'-monophosphoramidase activity
AXY_RS03835	COG1131	(ABC) transporter
AXY_RS03840	COG4473	ABC transporter
AXY_RS03850	COG4585	Histidine kinase
AXY_RS03855	COG2197	response regulator
AXY_RS03860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXY_RS03890	COG4133	protoheme IX ABC transporter activity
AXY_RS03940	COG1131	(ABC) transporter
AXY_RS04010	COG3507	Belongs to the glycosyl hydrolase 43 family
AXY_RS04015	COG1472	Belongs to the glycosyl hydrolase 3 family
AXY_RS04025	COG2972	Histidine kinase
AXY_RS04030	COG4753	response regulator
AXY_RS04030	COG2207	Transcriptional regulator
AXY_RS04045	COG4209	transmembrane transport
AXY_RS04050	COG0395	ABC-type sugar transport system, permease component
AXY_RS04065	COG1501	Belongs to the glycosyl hydrolase 31 family
AXY_RS04075	COG3507	Belongs to the glycosyl hydrolase 43 family
AXY_RS04080	COG1234	tRNA 3'-trailer cleavage
AXY_RS04085	COG0095	Lipoate-protein ligase
AXY_RS04105	COG0398	Pfam SNARE associated Golgi protein
AXY_RS04110	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AXY_RS04115	COG1074	ATP-dependent DNA helicase activity
AXY_RS04120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXY_RS04125	COG4605	iron ion homeostasis
AXY_RS04130	COG4604	ABC transporter, ATP-binding protein
AXY_RS04135	COG4607	ABC-type enterochelin transport system periplasmic component
AXY_RS04145	COG0835	chemotaxis
AXY_RS04150	COG2201	protein-glutamate methylesterase activity
AXY_RS04155	COG0840	transmembrane signaling receptor activity
AXY_RS04160	COG1960	acyl-CoA dehydrogenase activity
AXY_RS04170	COG0589	response to stress
AXY_RS04175	COG0735	belongs to the Fur family
AXY_RS04180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXY_RS04185	COG1121	(ABC) transporter
AXY_RS04190	COG5577	PFAM Coat F domain
AXY_RS04200	COG1393	Belongs to the ArsC family
AXY_RS04205	COG0509	glycine decarboxylation via glycine cleavage system
AXY_RS04210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXY_RS04215	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXY_RS04220	COG2011	ABC-type metal ion transport system permease component
AXY_RS04225	COG1464	Belongs to the NlpA lipoprotein family
AXY_RS04230	COG0396	ATPase activity
AXY_RS04235	COG0719	Fe-S assembly protein
AXY_RS04240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AXY_RS04245	COG0822	iron-sulfur transferase activity
AXY_RS04250	COG0719	Fe-S assembly protein
AXY_RS04255	COG1132	(ABC) transporter
AXY_RS04260	COG0737	Belongs to the 5'-nucleotidase family
AXY_RS04335	COG0733	neurotransmitter:sodium symporter activity
AXY_RS04340	COG0739	heme binding
AXY_RS04345	COG4470	Protein conserved in bacteria
AXY_RS04350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AXY_RS04355	COG0460	homoserine dehydrogenase
AXY_RS04360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXY_RS04365	COG0083	homoserine kinase activity
AXY_RS04370	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AXY_RS04375	COG0316	Belongs to the HesB IscA family
AXY_RS04380	COG0492	ferredoxin-NADP+ reductase activity
AXY_RS04385	COG1252	NADH dehydrogenase
AXY_RS04395	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AXY_RS04400	COG1268	BioY protein
AXY_RS04405	COG0813	purine-nucleoside phosphorylase activity
AXY_RS04410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_RS04415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AXY_RS04420	COG1098	S1 RNA binding domain
AXY_RS04425	COG0166	Belongs to the GPI family
AXY_RS04435	COG0367	asparagine synthase
AXY_RS04440	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AXY_RS04445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXY_RS04460	COG0494	nUDIX hydrolase
AXY_RS04465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXY_RS04475	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AXY_RS04480	COG0495	leucyl-tRNA aminoacylation
AXY_RS04505	COG1131	(ABC) transporter
AXY_RS04510	COG2188	Transcriptional regulator
AXY_RS04530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXY_RS04545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXY_RS04545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXY_RS04565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXY_RS04570	COG1115	amino acid carrier protein
AXY_RS04575	COG2081	HI0933 family
AXY_RS04580	COG2244	polysaccharide biosynthetic process
AXY_RS04585	COG1187	pseudouridine synthase activity
AXY_RS04590	COG1349	DNA-binding transcription factor activity
AXY_RS04600	COG0510	thiamine kinase activity
AXY_RS04610	COG1363	Peptidase, m42
AXY_RS04615	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AXY_RS04630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXY_RS04635	COG4848	Belongs to the UPF0354 family
AXY_RS04640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXY_RS04645	COG1674	ftsk spoiiie
AXY_RS04655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXY_RS04665	COG4980	gas vesicle protein
AXY_RS04675	COG0849	cell division
AXY_RS04680	COG1605	Chorismate mutase
AXY_RS04680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AXY_RS04705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXY_RS04715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXY_RS04720	COG2203	Gaf domain
AXY_RS04720	COG2199	diguanylate cyclase activity
AXY_RS04725	COG1956	GAF domain-containing protein
AXY_RS04730	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AXY_RS04740	COG1104	cysteine desulfurase activity
AXY_RS04745	COG0301	tRNA thio-modification
AXY_RS04760	COG3874	Sporulation protein YtfJ
AXY_RS04765	COG0827	DNA restriction-modification system
AXY_RS04770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AXY_RS04775	COG0589	response to stress
AXY_RS04780	COG4109	DRTGG domain
AXY_RS04785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AXY_RS04800	COG0587	DNA-directed DNA polymerase activity
AXY_RS04805	COG0281	malic enzyme
AXY_RS04810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AXY_RS04820	COG0205	6-phosphofructokinase activity
AXY_RS04830	COG3030	protein affecting phage T7 exclusion by the F plasmid
AXY_RS04840	COG2707	UPF0756 membrane protein
AXY_RS04845	COG0372	Belongs to the citrate synthase family
AXY_RS04850	COG0538	isocitrate dehydrogenase activity
AXY_RS04855	COG0745	RESPONSE REGULATOR receiver
AXY_RS04860	COG5002	protein histidine kinase activity
AXY_RS04865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXY_RS04865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXY_RS04870	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AXY_RS04875	COG1971	Probably functions as a manganese efflux pump
AXY_RS04880	COG0237	dephospho-CoA kinase activity
AXY_RS04890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AXY_RS04895	COG3611	Membrane attachment protein
AXY_RS04900	COG1484	DNA-dependent DNA replication
AXY_RS04910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXY_RS04920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXY_RS04925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXY_RS04935	COG3326	Membrane
AXY_RS04945	COG0756	dUTP diphosphatase activity
AXY_RS04950	COG1363	Peptidase, m42
AXY_RS04955	COG1136	(ABC) transporter
AXY_RS04960	COG0577	efflux transmembrane transporter activity
AXY_RS04960	COG1136	(ABC) transporter
AXY_RS04970	COG0741	lytic transglycosylase activity
AXY_RS04980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXY_RS04985	COG1388	LysM domain
AXY_RS04985	COG0791	NLP P60 protein
AXY_RS04990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXY_RS04995	COG0072	phenylalanine-tRNA ligase activity
AXY_RS04995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXY_RS05000	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXY_RS05005	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AXY_RS05010	COG1286	toxin biosynthetic process
AXY_RS05015	COG1796	DNA polymerase
AXY_RS05015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AXY_RS05020	COG1193	negative regulation of DNA recombination
AXY_RS05025	COG3118	belongs to the thioredoxin family
AXY_RS05030	COG0322	excinuclease ABC activity
AXY_RS05040	COG2197	response regulator
AXY_RS05060	COG2801	Transposase and inactivated derivatives
AXY_RS05070	COG1846	Transcriptional regulator
AXY_RS05075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AXY_RS05080	COG5401	PFAM Sporulation and spore germination
AXY_RS05085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AXY_RS05090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXY_RS05095	COG0622	Phosphoesterase
AXY_RS05130	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXY_RS05135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXY_RS05155	COG1388	LysM domain
AXY_RS05155	COG1388	LysM domain
AXY_RS05165	COG0525	valine-tRNA ligase activity
AXY_RS05170	COG3706	GGDEF domain
AXY_RS05175	COG0285	dihydrofolate synthase activity
AXY_RS05195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AXY_RS05205	COG1459	type II secretion system
AXY_RS05215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AXY_RS05240	COG2003	Belongs to the UPF0758 family
AXY_RS05250	COG1077	Cell shape determining protein MreB Mrl
AXY_RS05270	COG2894	cell division
AXY_RS05280	COG1994	Peptidase M50
AXY_RS05285	COG1530	ribonuclease E activity
AXY_RS05295	COG2868	ribosomal protein
AXY_RS05300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXY_RS05310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXY_RS05315	COG4492	Belongs to the UPF0735 family
AXY_RS05320	COG0077	Prephenate dehydratase
AXY_RS05325	COG1827	regulation of RNA biosynthetic process
AXY_RS05335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXY_RS05340	COG0217	transcriptional regulatory protein
AXY_RS05350	COG0632	four-way junction helicase activity
AXY_RS05355	COG2255	four-way junction helicase activity
AXY_RS05360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AXY_RS05365	COG0343	queuine tRNA-ribosyltransferase activity
AXY_RS05370	COG1862	Preprotein translocase
AXY_RS05385	COG2323	membrane
AXY_RS05390	COG2244	polysaccharide biosynthetic process
AXY_RS05400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXY_RS05400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXY_RS05405	COG5416	Lipopolysaccharide assembly protein A domain
AXY_RS05410	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AXY_RS05410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AXY_RS05415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXY_RS05420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXY_RS05425	COG1490	D-aminoacyl-tRNA deacylase activity
AXY_RS05430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXY_RS05435	COG0704	Plays a role in the regulation of phosphate uptake
AXY_RS05440	COG4991	sh3 domain protein
AXY_RS05440	COG3103	Sh3 type 3 domain protein
AXY_RS05440	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXY_RS05445	COG0124	histidyl-tRNA synthetase
AXY_RS05450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXY_RS05460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXY_RS05465	COG1959	2 iron, 2 sulfur cluster binding
AXY_RS05470	COG1104	cysteine desulfurase activity
AXY_RS05475	COG0482	sulfurtransferase activity
AXY_RS05495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXY_RS05505	COG0628	permease
AXY_RS05510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXY_RS05515	COG4472	Bacterial protein of unknown function (DUF965)
AXY_RS05520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXY_RS05525	COG3906	Belongs to the UPF0473 family
AXY_RS05535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AXY_RS05540	COG4122	O-methyltransferase activity
AXY_RS05545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXY_RS05555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AXY_RS05565	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AXY_RS05570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AXY_RS05575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXY_RS05580	COG1534	Rna-binding protein
AXY_RS05585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXY_RS05590	COG1713	HD superfamily hydrolase involved in NAD metabolism
AXY_RS05595	COG0799	negative regulation of ribosome biogenesis
AXY_RS05600	COG2226	methyltransferase
AXY_RS05610	COG2131	deaminase
AXY_RS05615	COG0658	competence protein
AXY_RS05615	COG2333	competence protein COMEC
AXY_RS05620	COG1466	dna polymerase III delta subunit
AXY_RS05625	COG0268	Binds directly to 16S ribosomal RNA
AXY_RS05630	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AXY_RS05635	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXY_RS05645	COG0481	GTPase activity
AXY_RS05650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXY_RS05655	COG1420	regulation of RNA biosynthetic process
AXY_RS05660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXY_RS05665	COG0443	Heat shock 70 kDa protein
AXY_RS05670	COG0484	heat shock protein binding
AXY_RS05675	COG2264	protein methyltransferase activity
AXY_RS05680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXY_RS05685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AXY_RS05690	COG1610	YqeY-like protein
AXY_RS05695	COG1030	water channel activity
AXY_RS05700	COG4864	UPF0365 protein
AXY_RS05720	COG1702	phosphate starvation-inducible protein PhoH
AXY_RS05725	COG1480	7TM receptor with intracellular HD hydrolase
AXY_RS05730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXY_RS05735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AXY_RS05740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXY_RS05745	COG1381	Involved in DNA repair and RecF pathway recombination
AXY_RS05750	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AXY_RS05755	COG0752	glycyl-tRNA synthetase alpha subunit
AXY_RS05760	COG0751	glycine-tRNA ligase activity
AXY_RS05765	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AXY_RS05770	COG0358	DNA primase activity
AXY_RS05775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXY_RS05785	COG2384	SAM-dependent methyltransferase
AXY_RS05790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXY_RS05800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AXY_RS05825	COG0704	Plays a role in the regulation of phosphate uptake
AXY_RS05860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AXY_RS05865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AXY_RS05870	COG0768	penicillin binding
AXY_RS05890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXY_RS05895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXY_RS05905	COG1940	carbohydrate kinase activity
AXY_RS05910	COG1368	sulfuric ester hydrolase activity
AXY_RS05915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXY_RS05940	COG4537	Required for transformation and DNA binding
AXY_RS05945	COG1459	type II secretion system
AXY_RS05950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AXY_RS05970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AXY_RS05975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXY_RS05980	COG1321	iron dependent repressor
AXY_RS05985	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXY_RS06000	COG0006	proline dipeptidase activity
AXY_RS06005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXY_RS06010	COG3854	ATPases associated with a variety of cellular activities
AXY_RS06050	COG0511	ligase activity, forming carbon-carbon bonds
AXY_RS06055	COG0439	Biotin carboxylase
AXY_RS06060	COG1302	Protein conserved in bacteria
AXY_RS06065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXY_RS06070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXY_RS06080	COG1722	exodeoxyribonuclease VII activity
AXY_RS06085	COG0142	geranyltranstransferase activity
AXY_RS06090	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AXY_RS06100	COG0497	DNA recombination
AXY_RS06105	COG0750	zinc metalloprotease
AXY_RS06115	COG2340	Cysteine-rich secretory protein family
AXY_RS06120	COG0527	aspartate kinase activity
AXY_RS06125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXY_RS06130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AXY_RS06135	COG0022	dehydrogenase e1 component
AXY_RS06140	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXY_RS06145	COG4129	membrane
AXY_RS06150	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXY_RS06155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXY_RS06160	COG1234	tRNA 3'-trailer cleavage
AXY_RS06165	COG0584	glycerophosphoryl diester phosphodiesterase
AXY_RS06170	COG0300	oxidoreductase activity
AXY_RS06175	COG0494	nUDIX hydrolase
AXY_RS06180	COG1379	DNA repair
AXY_RS06185	COG1300	Membrane
AXY_RS06190	COG0735	belongs to the Fur family
AXY_RS06200	COG4974	Belongs to the 'phage' integrase family
AXY_RS06205	COG1686	Belongs to the peptidase S11 family
AXY_RS06225	COG0697	spore germination
AXY_RS06235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXY_RS06240	COG0456	acetyltransferase
AXY_RS06245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AXY_RS06250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AXY_RS06255	COG1686	Belongs to the peptidase S11 family
AXY_RS06260	COG2715	membrane protein required for spore maturation
AXY_RS06265	COG0700	Nucleoside recognition
AXY_RS06270	COG1187	pseudouridine synthase activity
AXY_RS06275	COG0745	RESPONSE REGULATOR receiver
AXY_RS06280	COG5002	protein histidine kinase activity
AXY_RS06285	COG1595	DNA-templated transcription, initiation
AXY_RS06300	COG4955	Helix-turn-helix domain
AXY_RS06305	COG0514	ATP-dependent DNA helicase (RecQ)
AXY_RS06315	COG4862	establishment of competence for transformation
AXY_RS06320	COG3409	Peptidoglycan-binding domain 1 protein
AXY_RS06320	COG3773	Cell wall hydrolase
AXY_RS06325	COG2959	enzyme of heme biosynthesis
AXY_RS06330	COG3344	reverse transcriptase
AXY_RS06335	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AXY_RS06350	COG0539	negative regulation of cytoplasmic translation
AXY_RS06360	COG1160	GTP binding
AXY_RS06365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXY_RS06375	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AXY_RS06380	COG0776	regulation of translation
AXY_RS06395	COG0142	geranyltranstransferase activity
AXY_RS06400	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AXY_RS06410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXY_RS06415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AXY_RS06420	COG4401	Chorismate mutase type I
AXY_RS06425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXY_RS06430	COG0287	Prephenate dehydrogenase
AXY_RS06435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXY_RS06445	COG0457	Tetratricopeptide repeat
AXY_RS06450	COG5582	Belongs to the UPF0302 family
AXY_RS06455	COG4347	Protein of unknown function (DUF1405)
AXY_RS06465	COG1694	Mazg nucleotide pyrophosphohydrolase
AXY_RS06470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXY_RS06475	COG1803	Methylglyoxal synthase
AXY_RS06480	COG0617	tRNA 3'-terminal CCA addition
AXY_RS06485	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AXY_RS06485	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AXY_RS06495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXY_RS06500	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AXY_RS06505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXY_RS06505	COG1199	ATP-dependent helicase activity
AXY_RS06515	COG0436	Aminotransferase
AXY_RS06520	COG0017	Asparaginyl-tRNA synthetase
AXY_RS06525	COG3935	DnaD domain protein
AXY_RS06530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AXY_RS06535	COG4499	WXG100 protein secretion system (Wss), protein YukC
AXY_RS06535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXY_RS06540	COG3331	DNA recombination
AXY_RS06555	COG4474	Belongs to the UPF0398 family
AXY_RS06560	COG3599	regulation of cell shape
AXY_RS06565	COG0116	Belongs to the methyltransferase superfamily
AXY_RS06570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AXY_RS06580	COG0328	RNA-DNA hybrid ribonuclease activity
AXY_RS06590	COG0791	NLP P60 protein
AXY_RS06590	COG1388	LysM domain
AXY_RS06595	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AXY_RS06600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AXY_RS06610	COG0420	3'-5' exonuclease activity
AXY_RS06615	COG0419	ATPase involved in DNA repair
AXY_RS06630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXY_RS06630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXY_RS06650	COG1254	Belongs to the acylphosphatase family
AXY_RS06655	COG5646	InterPro IPR014922
AXY_RS06660	COG0826	peptidase U32
AXY_RS06665	COG0826	peptidase U32
AXY_RS06690	COG0346	lactoylglutathione lyase activity
AXY_RS06695	COG1307	EDD domain protein, DegV family
AXY_RS06705	COG0723	plastoquinol--plastocyanin reductase activity
AXY_RS06705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXY_RS06720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXY_RS06725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXY_RS06735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AXY_RS06740	COG0628	permease
AXY_RS06745	COG2814	Major facilitator Superfamily
AXY_RS06755	COG3425	synthase
AXY_RS06760	COG0183	Belongs to the thiolase family
AXY_RS06765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AXY_RS06775	COG2059	Chromate
AXY_RS06785	COG0326	Molecular chaperone. Has ATPase activity
AXY_RS06795	COG1394	ATPase activity, coupled to movement of substances
AXY_RS06800	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AXY_RS06805	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AXY_RS06810	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
AXY_RS06815	COG1527	subunit (C
AXY_RS06825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXY_RS06830	COG1269	ATP hydrolysis coupled proton transport
AXY_RS06840	COG2996	Protein conserved in bacteria
AXY_RS06850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXY_RS06855	COG1227	inorganic diphosphatase activity
AXY_RS06865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXY_RS06870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXY_RS06875	COG0583	DNA-binding transcription factor activity
AXY_RS06880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXY_RS06885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXY_RS06885	COG0140	phosphoribosyl-ATP diphosphatase activity
AXY_RS06890	COG0107	imidazoleglycerol-phosphate synthase activity
AXY_RS06900	COG0131	Imidazoleglycerol-phosphate dehydratase
AXY_RS06905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXY_RS06910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXY_RS06915	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AXY_RS06920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AXY_RS06930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXY_RS06935	COG0187	DNA topoisomerase II activity
AXY_RS06940	COG1832	CoA-binding protein
AXY_RS06945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AXY_RS06950	COG1469	GTP cyclohydrolase I activity
AXY_RS06970	COG0824	Thioesterase
AXY_RS06975	COG0464	growth
AXY_RS06980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXY_RS06985	COG4191	Histidine kinase
AXY_RS06990	COG3763	UPF0154 protein
AXY_RS07005	COG4224	UPF0291 protein
AXY_RS07015	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXY_RS07020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXY_RS07025	COG0840	transmembrane signaling receptor activity
AXY_RS07035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AXY_RS07040	COG0531	amino acid
AXY_RS07080	COG2824	Alkylphosphonate utilization operon protein PhnA
AXY_RS07085	COG0500	methyltransferase
AXY_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_RS07235	COG2207	Transcriptional regulator
AXY_RS07240	COG1486	melibiose metabolic process
AXY_RS07250	COG1064	alcohol dehydrogenase
AXY_RS07270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXY_RS07275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXY_RS07280	COG0464	growth
AXY_RS07290	COG1923	regulation of RNA biosynthetic process
AXY_RS07295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXY_RS07300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AXY_RS07305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AXY_RS07320	COG4550	Control of competence regulator ComK, YlbF/YmcA
AXY_RS07330	COG2359	stage V sporulation protein S
AXY_RS07335	COG1692	metallophosphoesterase
AXY_RS07340	COG1418	mRNA catabolic process
AXY_RS07345	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXY_RS07350	COG1058	Belongs to the CinA family
AXY_RS07350	COG1546	Belongs to the CinA family
AXY_RS07355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXY_RS07360	COG1426	Protein conserved in bacteria
AXY_RS07365	COG0612	Peptidase, M16
AXY_RS07370	COG0612	Peptidase, M16
AXY_RS07375	COG2188	Transcriptional regulator
AXY_RS07385	COG1674	ftsk spoiiie
AXY_RS07390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXY_RS07395	COG0527	aspartate kinase activity
AXY_RS07400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AXY_RS07405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AXY_RS07410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXY_RS07415	COG1873	PFAM PRC-barrel domain
AXY_RS07425	COG1185	polyribonucleotide nucleotidyltransferase activity
AXY_RS07430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AXY_RS07435	COG0196	riboflavin kinase activity
AXY_RS07440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXY_RS07445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXY_RS07450	COG1550	Protein conserved in bacteria
AXY_RS07455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXY_RS07460	COG1358	cellular component organization or biogenesis
AXY_RS07465	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AXY_RS07470	COG0195	Participates in both transcription termination and antitermination
AXY_RS07475	COG0779	Required for maturation of 30S ribosomal subunits
AXY_RS07480	COG2176	DNA-directed DNA polymerase activity
AXY_RS07485	COG0442	prolyl-tRNA aminoacylation
AXY_RS07490	COG0750	zinc metalloprotease
AXY_RS07495	COG4589	Belongs to the CDS family
AXY_RS07500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXY_RS07505	COG0233	cytoplasmic translational termination
AXY_RS07515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXY_RS07520	COG0052	Belongs to the universal ribosomal protein uS2 family
AXY_RS07540	COG1191	sigma factor activity
AXY_RS07545	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AXY_RS07550	COG1776	CheC inhibitor of MCP methylation
AXY_RS07555	COG0835	chemotaxis
AXY_RS07560	COG2198	Histidine kinase
AXY_RS07560	COG0643	Histidine kinase
AXY_RS07565	COG2201	protein-glutamate methylesterase activity
AXY_RS07570	COG0455	bacterial-type flagellum organization
AXY_RS07575	COG1419	protein localization to endoplasmic reticulum
AXY_RS07580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXY_RS07585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXY_RS07590	COG1684	flagellar biosynthetic protein fliR
AXY_RS07595	COG1987	bacterial-type flagellum assembly
AXY_RS07600	COG1338	Plays a role in the flagellum-specific transport system
AXY_RS07605	COG3190	flagellar
AXY_RS07610	COG2201	protein-glutamate methylesterase activity
AXY_RS07615	COG1776	CheC inhibitor of MCP methylation
AXY_RS07615	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXY_RS07620	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXY_RS07630	COG1582	Flagellar protein (FlbD)
AXY_RS07635	COG4786	Flagellar basal body rod
AXY_RS07645	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AXY_RS07675	COG1157	protein secretion by the type III secretion system
AXY_RS07685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXY_RS07690	COG1766	The M ring may be actively involved in energy transduction
AXY_RS07695	COG1677	Flagellar hook-basal body complex protein FliE
AXY_RS07700	COG1558	bacterial-type flagellum-dependent cell motility
AXY_RS07705	COG1815	bacterial-type flagellum-dependent cell motility
AXY_RS07710	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AXY_RS07715	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AXY_RS07720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AXY_RS07725	COG4974	Belongs to the 'phage' integrase family
AXY_RS07730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXY_RS07735	COG0758	DNA mediated transformation
AXY_RS07740	COG2257	FlhB HrpN YscU SpaS Family
AXY_RS07750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXY_RS07755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AXY_RS07765	COG0335	large ribosomal subunit rRNA binding
AXY_RS07770	COG0336	Belongs to the RNA methyltransferase TrmD family
AXY_RS07775	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXY_RS07780	COG1837	Belongs to the UPF0109 family
AXY_RS07785	COG0228	four-way junction DNA binding
AXY_RS07790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AXY_RS07795	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AXY_RS07800	COG0552	protein localization to endoplasmic reticulum
AXY_RS07805	COG1196	nuclear chromosome segregation
AXY_RS07810	COG4840	Belongs to the UPF0435 family
AXY_RS07815	COG0571	ribonuclease III activity
AXY_RS07820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXY_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_RS07830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXY_RS07835	COG0416	fatty acid biosynthetic process
AXY_RS07840	COG1349	DNA-binding transcription factor activity
AXY_RS07845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AXY_RS07850	COG1461	Dihydroxyacetone kinase
AXY_RS07855	COG1302	Protein conserved in bacteria
AXY_RS07860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXY_RS07870	COG1564	THIamine pyrophosphokinase
AXY_RS07875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXY_RS07880	COG1162	GTPase activity
AXY_RS07885	COG2815	serine threonine protein kinase
AXY_RS07885	COG0515	serine threonine protein kinase
AXY_RS07890	COG0631	protein serine/threonine phosphatase activity
AXY_RS07895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AXY_RS07895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXY_RS07900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXY_RS07905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AXY_RS07910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AXY_RS07915	COG1758	RNA polymerase activity
AXY_RS07920	COG0194	GDP metabolic process
AXY_RS07925	COG2052	Domain of unknown function (DUF370)
AXY_RS07930	COG1561	YicC-like family, N-terminal region
AXY_RS07935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AXY_RS07955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXY_RS07960	COG0284	orotidine-5'-phosphate decarboxylase activity
AXY_RS07965	COG0167	dihydroorotate dehydrogenase activity
AXY_RS07970	COG0543	2 iron, 2 sulfur cluster binding
AXY_RS07975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXY_RS07980	COG0540	Belongs to the ATCase OTCase family
AXY_RS07990	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AXY_RS07995	COG0564	pseudouridine synthase activity
AXY_RS08000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AXY_RS08005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXY_RS08010	COG3599	regulation of cell shape
AXY_RS08015	COG2302	S4 RNA-binding domain
AXY_RS08020	COG0762	integral membrane protein
AXY_RS08025	COG1799	cell septum assembly
AXY_RS08030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXY_RS08035	COG1496	oxidoreductase activity
AXY_RS08045	COG1191	sigma factor activity
AXY_RS08050	COG1191	sigma factor activity
AXY_RS08060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AXY_RS08065	COG0849	cell division
AXY_RS08070	COG3856	small basic protein
AXY_RS08075	COG3879	Bacterial protein of unknown function (DUF881)
AXY_RS08080	COG3879	Bacterial protein of unknown function (DUF881)
AXY_RS08085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AXY_RS08095	COG1136	(ABC) transporter
AXY_RS08095	COG0577	efflux transmembrane transporter activity
AXY_RS08100	COG0772	Belongs to the SEDS family
AXY_RS08105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXY_RS08110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXY_RS08115	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXY_RS08125	COG0768	penicillin binding
AXY_RS08130	COG0768	penicillin binding
AXY_RS08135	COG4839	cell division protein FtsL
AXY_RS08140	COG0275	rRNA processing
AXY_RS08145	COG2001	Belongs to the MraZ family
AXY_RS08160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AXY_RS08165	COG1399	metal-binding, possibly nucleic acid-binding protein
AXY_RS08170	COG1323	Belongs to the UPF0348 family
AXY_RS08175	COG3480	Lon protease (S16) C-terminal proteolytic domain
AXY_RS08180	COG3314	Sporulation integral membrane protein YlbJ
AXY_RS08185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXY_RS08190	COG0742	ribosomal rna small subunit methyltransferase
AXY_RS08195	COG4471	UPF0298 protein
AXY_RS08200	COG3679	Belongs to the UPF0342 family
AXY_RS08210	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AXY_RS08220	COG4838	Belongs to the UPF0358 family
AXY_RS08230	COG4896	Protein conserved in bacteria
AXY_RS08235	COG0483	inositol monophosphate 1-phosphatase activity
AXY_RS08240	COG4476	Belongs to the UPF0223 family
AXY_RS08245	COG0726	polysaccharide deacetylase
AXY_RS08275	COG0242	peptide deformylase activity
AXY_RS08285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AXY_RS08290	COG0569	domain protein
AXY_RS08295	COG1132	(ABC) transporter
AXY_RS08300	COG1132	(ABC) transporter
AXY_RS08305	COG0668	transmembrane transport
AXY_RS08310	COG0517	IMP dehydrogenase activity
AXY_RS08335	COG0681	Belongs to the peptidase S26 family
AXY_RS08345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXY_RS08370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXY_RS08390	COG0028	Belongs to the TPP enzyme family
AXY_RS08395	COG0440	acetolactate synthase activity
AXY_RS08400	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXY_RS08405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXY_RS08410	COG0473	3-isopropylmalate dehydrogenase activity
AXY_RS08415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXY_RS08420	COG0066	3-isopropylmalate dehydratase activity
AXY_RS08430	COG2706	6-phosphogluconolactonase activity
AXY_RS08435	COG1595	DNA-templated transcription, initiation
AXY_RS08445	COG1131	(ABC) transporter
AXY_RS08450	COG1725	Transcriptional regulator
AXY_RS08455	COG0400	carboxylic ester hydrolase activity
AXY_RS08470	COG0714	Associated with various cellular activities
AXY_RS08480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AXY_RS08500	COG1126	abc transporter atp-binding protein
AXY_RS08505	COG0765	amino acid transport
AXY_RS08510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXY_RS08515	COG0561	phosphatase activity
AXY_RS08540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AXY_RS08545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXY_RS08550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXY_RS08555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXY_RS08560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXY_RS08565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXY_RS08575	COG0356	it plays a direct role in the translocation of protons across the membrane
AXY_RS08595	COG1278	Cold shock
AXY_RS08605	COG5002	protein histidine kinase activity
AXY_RS08605	COG3850	Histidine kinase
AXY_RS08610	COG0745	RESPONSE REGULATOR receiver
AXY_RS08635	COG0561	phosphatase activity
AXY_RS08640	COG0561	phosphatase activity
AXY_RS08645	COG2201	protein-glutamate methylesterase activity
AXY_RS08650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXY_RS08655	COG1554	hydrolase, family 65, central catalytic
AXY_RS08665	COG0783	Belongs to the Dps family
AXY_RS08670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXY_RS08675	COG0785	Cytochrome C biogenesis protein
AXY_RS08680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXY_RS08700	COG0516	GMP reductase activity
AXY_RS08720	COG1408	metallophosphoesterase
AXY_RS08735	COG1363	Peptidase, m42
AXY_RS08745	COG4555	ABC transporter
AXY_RS08750	COG0166	Belongs to the GPI family
AXY_RS08755	COG0564	pseudouridine synthase activity
AXY_RS08780	COG1476	TRANSCRIPTIONal
AXY_RS08785	COG3711	transcriptional antiterminator
AXY_RS08790	COG2190	(PTS) system
AXY_RS08790	COG1263	PTS System
AXY_RS08790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_RS08795	COG2723	6-phospho-beta-galactosidase activity
AXY_RS08805	COG3693	PFAM glycoside hydrolase, family 10
AXY_RS08820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXY_RS08825	COG0366	Alpha amylase catalytic
AXY_RS08830	COG1523	belongs to the glycosyl hydrolase 13 family
AXY_RS08835	COG1523	belongs to the glycosyl hydrolase 13 family
AXY_RS08840	COG0366	Alpha amylase catalytic
AXY_RS08845	COG2203	Gaf domain
AXY_RS08845	COG2199	diguanylate cyclase activity
AXY_RS08855	COG3833	ABC-type maltose transport systems, permease component
AXY_RS08860	COG1175	transmembrane transport
AXY_RS08865	COG2182	Extracellular solute-binding protein
AXY_RS08875	COG1609	Transcriptional regulator
AXY_RS08885	COG1132	(ABC) transporter
AXY_RS08890	COG1132	(ABC) transporter
AXY_RS08900	COG0129	dihydroxy-acid dehydratase activity
AXY_RS08915	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_RS08920	COG0534	Mate efflux family protein
AXY_RS08935	COG3507	Belongs to the glycosyl hydrolase 43 family
AXY_RS08960	COG1132	(ABC) transporter
AXY_RS08965	COG0534	Mate efflux family protein
AXY_RS08970	COG0697	spore germination
AXY_RS08995	COG0772	Belongs to the SEDS family
AXY_RS09005	COG2153	protein acetylation
AXY_RS09010	COG2323	membrane
AXY_RS09040	COG2239	Acts as a magnesium transporter
AXY_RS09050	COG0564	pseudouridine synthase activity
AXY_RS09060	COG2357	RelA SpoT domain protein
AXY_RS09065	COG4116	CYTH
AXY_RS09070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AXY_RS09075	COG2814	Major facilitator Superfamily
AXY_RS09080	COG1164	Oligoendopeptidase f
AXY_RS09095	COG1393	Belongs to the ArsC family
AXY_RS09115	COG0601	transmembrane transport
AXY_RS09120	COG4608	Belongs to the ABC transporter superfamily
AXY_RS09135	COG4841	protein insertion into membrane
AXY_RS09140	COG0180	Tryptophanyl-tRNA synthetase
AXY_RS09155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXY_RS09160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXY_RS09180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXY_RS09185	COG2151	metal-sulfur cluster biosynthetic enzyme
AXY_RS09190	COG1073	alpha beta
AXY_RS09195	COG0561	phosphatase activity
AXY_RS09205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AXY_RS09210	COG1307	EDD domain protein, DegV family
AXY_RS09220	COG0791	NLP P60 protein
AXY_RS09220	COG3883	PFAM NLP P60 protein
AXY_RS09220	COG0791	NLP P60 protein
AXY_RS09220	COG3883	PFAM NLP P60 protein
AXY_RS09225	COG0710	3-dehydroquinate dehydratase activity
AXY_RS09230	COG1621	beta-fructofuranosidase activity
AXY_RS09235	COG1263	PTS System
AXY_RS09235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_RS09250	COG2972	Histidine kinase
AXY_RS09250	COG0745	RESPONSE REGULATOR receiver
AXY_RS09255	COG3279	Response regulator of the LytR AlgR family
AXY_RS09265	COG0557	exoribonuclease II activity
AXY_RS09275	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AXY_RS09280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_RS09285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXY_RS09310	COG0148	phosphopyruvate hydratase activity
AXY_RS09315	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AXY_RS09320	COG0149	triose-phosphate isomerase activity
AXY_RS09325	COG0126	phosphoglycerate kinase activity
AXY_RS09355	COG0740	serine-type endopeptidase activity
AXY_RS09360	COG3679	Belongs to the UPF0342 family
AXY_RS09370	COG2508	Transcriptional regulator
AXY_RS09375	COG3842	ATPase activity
AXY_RS09385	COG0114	fumarate hydratase activity
AXY_RS09390	COG1876	peptidase activity
AXY_RS09395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AXY_RS09410	COG0024	Methionine aminopeptidase
AXY_RS09425	COG1917	Cupin 2, conserved barrel domain protein
AXY_RS09425	COG2207	Transcriptional regulator
AXY_RS09445	COG1937	Protein conserved in bacteria
AXY_RS09460	COG1854	S-ribosylhomocysteine lyase activity
AXY_RS09475	COG0288	reversible hydration of carbon dioxide
AXY_RS09480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXY_RS09490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXY_RS09500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AXY_RS09505	COG1842	Phage shock protein A
AXY_RS09510	COG1842	Phage shock protein A
AXY_RS09540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AXY_RS09545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXY_RS09580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXY_RS09585	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AXY_RS09590	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AXY_RS09600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXY_RS09605	COG4786	Flagellar basal body rod
AXY_RS09605	COG1256	bacterial-type flagellum assembly
AXY_RS09625	COG1040	competence protein
AXY_RS09630	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AXY_RS09635	COG1307	EDD domain protein, DegV family
AXY_RS09640	COG2197	response regulator
AXY_RS09645	COG4585	Histidine kinase
AXY_RS09650	COG5578	integral membrane protein
AXY_RS09655	COG0395	ABC-type sugar transport system, permease component
AXY_RS09660	COG1175	transmembrane transport
AXY_RS09665	COG1653	transport
AXY_RS09670	COG2207	Transcriptional regulator
AXY_RS09675	COG2972	Histidine kinase
AXY_RS09680	COG1739	Uncharacterized protein family UPF0029
AXY_RS09685	COG3764	Sortase (surface protein transpeptidase)
AXY_RS09690	COG0768	penicillin binding
AXY_RS09780	COG0667	Aldo Keto reductase
AXY_RS09785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AXY_RS09790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AXY_RS09795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXY_RS09800	COG1874	Beta-galactosidase
AXY_RS09805	COG0662	Cupin 2, conserved barrel domain protein
AXY_RS09805	COG2207	Transcriptional regulator
AXY_RS09810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXY_RS09820	COG2357	RelA SpoT domain protein
AXY_RS09825	COG1272	protein, Hemolysin III
AXY_RS09830	COG1316	TRANSCRIPTIONal
AXY_RS09855	COG0840	transmembrane signaling receptor activity
AXY_RS09865	COG0205	6-phosphofructokinase activity
AXY_RS09880	COG1879	ABC-type sugar transport system periplasmic component
AXY_RS09885	COG1172	Belongs to the binding-protein-dependent transport system permease family
AXY_RS09890	COG1129	ABC transporter
AXY_RS09895	COG1869	D-ribose catabolic process
AXY_RS09900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXY_RS09905	COG1609	Transcriptional regulator
AXY_RS09920	COG0601	transmembrane transport
AXY_RS09925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXY_RS09935	COG2267	carboxylic ester hydrolase activity
AXY_RS09940	COG0534	Mate efflux family protein
AXY_RS09945	COG0840	transmembrane signaling receptor activity
AXY_RS09950	COG0667	Aldo Keto reductase
AXY_RS09965	COG1132	(ABC) transporter
AXY_RS09970	COG1132	(ABC) transporter
AXY_RS10015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AXY_RS10025	COG1942	4-Oxalocrotonate Tautomerase
AXY_RS10030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXY_RS10035	COG0626	cystathionine gamma-synthase activity
AXY_RS10090	COG3192	ethanolamine utilization protein
AXY_RS10100	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXY_RS10105	COG0583	DNA-binding transcription factor activity
AXY_RS10130	COG0438	transferase activity, transferring glycosyl groups
AXY_RS10140	COG0438	transferase activity, transferring glycosyl groups
AXY_RS10155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXY_RS10165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AXY_RS10170	COG4464	protein tyrosine phosphatase activity
AXY_RS10175	COG3859	Proton-coupled thiamine transporter YuaJ
AXY_RS10185	COG0489	protein tyrosine kinase activity
AXY_RS10190	COG3944	biosynthesis protein
AXY_RS10195	COG2200	EAL domain
AXY_RS10210	COG1316	TRANSCRIPTIONal
AXY_RS10215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXY_RS10225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXY_RS10235	COG1682	transport, permease protein
AXY_RS10245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXY_RS10250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXY_RS10260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXY_RS10265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AXY_RS10270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXY_RS10305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXY_RS10315	COG4786	Flagellar basal body rod
AXY_RS10320	COG4786	Flagellar basal body rod
AXY_RS10325	COG1077	Cell shape determining protein MreB Mrl
AXY_RS10330	COG1609	Transcriptional regulator
AXY_RS10345	COG0739	heme binding
AXY_RS10350	COG2385	sporulation resulting in formation of a cellular spore
AXY_RS10355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXY_RS10365	COG4836	Membrane
AXY_RS10370	COG1404	Belongs to the peptidase S8 family
AXY_RS10380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXY_RS10385	COG0698	ribose 5-phosphate isomerase
AXY_RS10390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXY_RS10395	COG1971	Probably functions as a manganese efflux pump
AXY_RS10400	COG0009	L-threonylcarbamoyladenylate synthase
AXY_RS10415	COG2890	protein-(glutamine-N5) methyltransferase activity
AXY_RS10420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXY_RS10425	COG1435	thymidine kinase activity
AXY_RS10430	COG0254	rRNA binding
AXY_RS10440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AXY_RS10445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXY_RS10450	COG0191	fructose-bisphosphate aldolase activity
AXY_RS10455	COG2204	response regulator
AXY_RS10460	COG0504	CTP synthase activity
AXY_RS10465	COG3343	RNA polymerase activity
AXY_RS10480	COG0018	arginyl-trna synthetase
AXY_RS10490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXY_RS10495	COG3465	dGTPase activity
AXY_RS10500	COG1078	dGTPase activity
AXY_RS10505	COG0095	Lipoate-protein ligase
AXY_RS10510	COG0280	phosphate acetyltransferase
AXY_RS10515	COG3773	Cell wall hydrolase
AXY_RS10525	COG2801	Transposase and inactivated derivatives
AXY_RS10540	COG0628	permease
AXY_RS10545	COG0514	ATP-dependent DNA helicase (RecQ)
AXY_RS10560	COG0488	(ABC) transporter
AXY_RS10565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXY_RS10580	COG2755	lipolytic protein G-D-S-L family
AXY_RS10600	COG2197	response regulator
AXY_RS10620	COG1970	mechanosensitive ion channel activity
AXY_RS10640	COG0488	(ABC) transporter
AXY_RS10645	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXY_RS10655	COG0159	tryptophan synthase activity
AXY_RS10665	COG0135	phosphoribosylanthranilate isomerase activity
AXY_RS10670	COG0134	indole-3-glycerol-phosphate synthase activity
AXY_RS10675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXY_RS10680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXY_RS10690	COG3584	3D domain protein
AXY_RS10690	COG1388	LysM domain
AXY_RS10700	COG0840	transmembrane signaling receptor activity
AXY_RS10710	COG5578	integral membrane protein
AXY_RS10715	COG0395	ABC-type sugar transport system, permease component
AXY_RS10720	COG1175	transmembrane transport
AXY_RS10735	COG2723	6-phospho-beta-galactosidase activity
AXY_RS10740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXY_RS10745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXY_RS10750	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AXY_RS10760	COG1660	Displays ATPase and GTPase activities
AXY_RS10770	COG1940	carbohydrate kinase activity
AXY_RS10790	COG0561	phosphatase activity
AXY_RS10800	COG0346	lactoylglutathione lyase activity
AXY_RS10810	COG2217	Heavy metal translocating P-type atpase
AXY_RS10830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AXY_RS10835	COG0363	glucosamine-6-phosphate deaminase activity
AXY_RS10845	COG3973	AAA domain
AXY_RS10850	COG0251	oxidation-reduction process
AXY_RS10855	COG0432	Pfam Uncharacterised protein family UPF0047
AXY_RS10860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXY_RS10875	COG1609	Transcriptional regulator
AXY_RS10890	COG0604	alcohol dehydrogenase
AXY_RS10900	COG0640	Transcriptional regulator
AXY_RS10910	COG2217	Heavy metal translocating P-type atpase
AXY_RS10915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXY_RS10920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXY_RS10925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AXY_RS10930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXY_RS10945	COG2966	Psort location CytoplasmicMembrane, score
AXY_RS10965	COG2226	methyltransferase
AXY_RS10985	COG1272	protein, Hemolysin III
AXY_RS11025	COG3458	cephalosporin-C deacetylase activity
AXY_RS11030	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AXY_RS11035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AXY_RS11040	COG1447	Phosphotransferase system cellobiose-specific component IIA
AXY_RS11045	COG2723	6-phospho-beta-galactosidase activity
AXY_RS11050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_RS11050	COG3711	transcriptional antiterminator
AXY_RS11055	COG1482	cell wall glycoprotein biosynthetic process
AXY_RS11065	COG1131	(ABC) transporter
AXY_RS11080	COG2188	Transcriptional regulator
AXY_RS11085	COG0366	Alpha amylase catalytic
AXY_RS11090	COG1263	PTS System
AXY_RS11090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AXY_RS11095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXY_RS11100	COG2217	Heavy metal translocating P-type atpase
AXY_RS11105	COG0739	heme binding
AXY_RS11115	COG4086	secreted protein
AXY_RS11120	COG0110	maltose O-acetyltransferase activity
AXY_RS11125	COG0450	alkyl hydroperoxide reductase
AXY_RS11135	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_RS11160	COG0157	Belongs to the NadC ModD family
AXY_RS11170	COG1253	flavin adenine dinucleotide binding
AXY_RS11175	COG0534	Mate efflux family protein
AXY_RS11180	COG2032	superoxide dismutase activity
AXY_RS11185	COG0840	transmembrane signaling receptor activity
AXY_RS11190	COG0656	L-ascorbic acid biosynthetic process
AXY_RS11210	COG2155	Conserved Protein
AXY_RS11215	COG1902	pentaerythritol trinitrate reductase activity
AXY_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
AXY_RS11245	COG0561	phosphatase activity
AXY_RS11255	COG2801	Transposase and inactivated derivatives
AXY_RS11280	COG1132	(ABC) transporter
AXY_RS11285	COG3458	cephalosporin-C deacetylase activity
AXY_RS11290	COG0667	Aldo Keto reductase
AXY_RS11305	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AXY_RS11310	COG3833	ABC-type maltose transport systems, permease component
AXY_RS11315	COG1175	transmembrane transport
AXY_RS11320	COG2182	Extracellular solute-binding protein
AXY_RS11325	COG3385	transposase activity
AXY_RS11340	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AXY_RS11345	COG2942	2-epimerase
AXY_RS11350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AXY_RS11360	COG1447	Phosphotransferase system cellobiose-specific component IIA
AXY_RS11365	COG2723	6-phospho-beta-galactosidase activity
AXY_RS11370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXY_RS11370	COG3711	transcriptional antiterminator
AXY_RS11380	COG1482	cell wall glycoprotein biosynthetic process
AXY_RS11400	COG2723	6-phospho-beta-galactosidase activity
AXY_RS11415	COG1940	carbohydrate kinase activity
AXY_RS11430	COG2801	Transposase and inactivated derivatives
AXY_RS11460	COG1216	Glycosyl transferase, family 2
AXY_RS11470	COG3250	beta-galactosidase activity
AXY_RS11490	COG3279	Response regulator of the LytR AlgR family
AXY_RS11495	COG0840	transmembrane signaling receptor activity
AXY_RS11500	COG1216	Glycosyl transferase, family 2
AXY_RS11515	COG1472	Belongs to the glycosyl hydrolase 3 family
AXY_RS11525	COG1472	Belongs to the glycosyl hydrolase 3 family
AXY_RS11540	COG0562	UDP-galactopyranose mutase
AXY_RS11565	COG1464	Belongs to the NlpA lipoprotein family
AXY_RS11570	COG2011	ABC-type metal ion transport system permease component
AXY_RS11575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXY_RS11595	COG0726	polysaccharide deacetylase
AXY_RS11600	COG0564	pseudouridine synthase activity
AXY_RS11615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AXY_RS11620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AXY_RS11640	COG1584	GPR1 FUN34 yaaH family protein
AXY_RS11645	COG1902	pentaerythritol trinitrate reductase activity
AXY_RS11655	COG0129	dihydroxy-acid dehydratase activity
AXY_RS11665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AXY_RS11665	COG1328	CTP reductase activity
AXY_RS11690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AXY_RS11695	COG1177	transmembrane transport
AXY_RS11700	COG1176	ABC-type spermidine putrescine transport system, permease component I
AXY_RS11705	COG3842	ATPase activity
AXY_RS11710	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXY_RS11720	COG1132	(ABC) transporter
AXY_RS11730	COG0625	glutathione transferase activity
AXY_RS11735	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXY_RS11740	COG1215	transferase activity, transferring glycosyl groups
AXY_RS11745	COG5298	Protein conserved in bacteria
AXY_RS11755	COG0659	secondary active sulfate transmembrane transporter activity
AXY_RS11760	COG0840	transmembrane signaling receptor activity
AXY_RS11765	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXY_RS11780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXY_RS11785	COG3655	Transcriptional regulator
AXY_RS11795	COG0346	lactoylglutathione lyase activity
AXY_RS11845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXY_RS11850	COG0515	serine threonine protein kinase
AXY_RS11850	COG2815	serine threonine protein kinase
AXY_RS11855	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AXY_RS11860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AXY_RS11875	COG1253	flavin adenine dinucleotide binding
AXY_RS11885	COG4720	Psort location CytoplasmicMembrane, score
AXY_RS11895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AXY_RS11935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXY_RS11940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AXY_RS11945	COG4853	Protein conserved in bacteria
AXY_RS11950	COG4863	YycH protein
AXY_RS11955	COG5002	protein histidine kinase activity
AXY_RS11960	COG0745	RESPONSE REGULATOR receiver
AXY_RS11970	COG1196	nuclear chromosome segregation
AXY_RS11970	COG0741	lytic transglycosylase activity
AXY_RS11970	COG0739	heme binding
AXY_RS11980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXY_RS11985	COG0305	Participates in initiation and elongation during chromosome replication
AXY_RS11990	COG0359	binds to the 23S rRNA
AXY_RS11995	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AXY_RS12000	COG4241	membrane
AXY_RS12005	COG1011	Hydrolase
AXY_RS12010	COG0584	glycerophosphoryl diester phosphodiesterase
AXY_RS12015	COG0534	Mate efflux family protein
AXY_RS12020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXY_RS12025	COG4658	electron transport chain
AXY_RS12030	COG4656	Part of a membrane complex involved in electron transport
AXY_RS12035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXY_RS12045	COG0360	Binds together with S18 to 16S ribosomal RNA
AXY_RS12050	COG0012	GTP binding
AXY_RS12055	COG4481	Protein conserved in bacteria
AXY_RS12060	COG3949	Membrane
AXY_RS12070	COG1475	DNA binding
AXY_RS12075	COG1192	Involved in chromosome partitioning
AXY_RS12080	COG1475	DNA binding
AXY_RS12085	COG0357	Ribosomal RNA small subunit methyltransferase G
AXY_RS12090	COG0445	tRNA wobble uridine modification
AXY_RS12095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AXY_RS12100	COG1847	R3H domain protein
AXY_RS12105	COG0706	membrane insertase activity
AXY_RS12110	COG0594	ribonuclease P activity
AXY_RS12115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AXY_RS12175	COG0739	heme binding
AXY_RS12265	COG1388	LysM domain
AXY_RS12285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXY_RS12290	COG3693	PFAM glycoside hydrolase, family 10
AXY_RS12300	COG3300	MHYT domain
AXY_RS12300	COG5001	Diguanylate cyclase
AXY_RS12315	COG5002	protein histidine kinase activity
AXY_RS12315	COG3447	MASE1 domain protein
AXY_RS12315	COG5001	Diguanylate cyclase
AXY_RS12340	COG0438	transferase activity, transferring glycosyl groups
AXY_RS12350	COG0840	transmembrane signaling receptor activity
AXY_RS12370	COG0726	polysaccharide deacetylase