locus-tag	class	description
OCU49_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OCU49_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OCU49_RS00020	COG0187	DNA topoisomerase II activity
OCU49_RS00030	COG0300	oxidoreductase activity
OCU49_RS00055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OCU49_RS00060	COG1522	sequence-specific DNA binding
OCU49_RS00065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OCU49_RS00065	COG4651	solute:proton antiporter activity
OCU49_RS00075	COG0508	dehydrogenase complex catalyzes the overall conversion of
OCU49_RS00095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OCU49_RS00100	COG0318	PFAM AMP-dependent synthetase and ligase
OCU49_RS00105	COG1024	Enoyl-CoA hydratase
OCU49_RS00110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCU49_RS00115	COG1522	sequence-specific DNA binding
OCU49_RS00120	COG0508	dehydrogenase complex catalyzes the overall conversion of
OCU49_RS00120	COG0596	Alpha beta hydrolase
OCU49_RS00135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS00145	COG0583	DNA-binding transcription factor activity
OCU49_RS00150	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OCU49_RS00160	COG0840	transmembrane signaling receptor activity
OCU49_RS00210	COG4251	negative regulation of phosphorylation
OCU49_RS00210	COG3706	GGDEF domain
OCU49_RS00210	COG2203	Gaf domain
OCU49_RS00210	COG5001	Diguanylate cyclase
OCU49_RS00215	COG0702	epimerase
OCU49_RS00220	COG0583	DNA-binding transcription factor activity
OCU49_RS00230	COG0730	response to heat
OCU49_RS00240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OCU49_RS00245	COG0751	glycine-tRNA ligase activity
OCU49_RS00250	COG0752	glycyl-tRNA synthetase alpha subunit
OCU49_RS00260	COG1560	Kdo2-lipid A biosynthetic process
OCU49_RS00265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OCU49_RS00270	COG0569	domain protein
OCU49_RS00275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OCU49_RS00280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OCU49_RS00285	COG0242	peptide deformylase activity
OCU49_RS00295	COG0758	DNA mediated transformation
OCU49_RS00300	COG0009	L-threonylcarbamoyladenylate synthase
OCU49_RS00305	COG0408	coproporphyrinogen oxidase activity
OCU49_RS00310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OCU49_RS00315	COG1067	ATP-dependent peptidase activity
OCU49_RS00320	COG1744	ABC transporter substrate-binding protein PnrA-like
OCU49_RS00325	COG3845	ABC transporter
OCU49_RS00335	COG1079	Belongs to the binding-protein-dependent transport system permease family
OCU49_RS00340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OCU49_RS00355	COG0501	Belongs to the peptidase M48B family
OCU49_RS00365	COG5265	(ABC) transporter
OCU49_RS00370	COG0840	transmembrane signaling receptor activity
OCU49_RS00375	COG0583	DNA-binding transcription factor activity
OCU49_RS00395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OCU49_RS00400	COG0583	DNA-binding transcription factor activity
OCU49_RS00445	COG0107	imidazoleglycerol-phosphate synthase activity
OCU49_RS00450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OCU49_RS00455	COG0131	Imidazoleglycerol-phosphate dehydratase
OCU49_RS00465	COG1194	a g-specific adenine glycosylase
OCU49_RS00485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCU49_RS00490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCU49_RS00500	COG0625	glutathione transferase activity
OCU49_RS00515	COG2358	TRAP transporter, solute receptor (TAXI family
OCU49_RS00545	COG0784	Response regulator, receiver
OCU49_RS00545	COG3437	response regulator, receiver
OCU49_RS00560	COG0784	Response regulator, receiver
OCU49_RS00560	COG2205	protein histidine kinase activity
OCU49_RS00560	COG5002	protein histidine kinase activity
OCU49_RS00570	COG0405	Gamma-glutamyltransferase
OCU49_RS00585	COG2268	Band 7 protein
OCU49_RS00610	COG1561	YicC-like family, N-terminal region
OCU49_RS00615	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OCU49_RS00635	COG0583	DNA-binding transcription factor activity
OCU49_RS00640	COG0583	DNA-binding transcription factor activity
OCU49_RS00660	COG0583	DNA-binding transcription factor activity
OCU49_RS00675	COG0583	DNA-binding transcription factor activity
OCU49_RS00690	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS00705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OCU49_RS00710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS00710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS00730	COG2358	TRAP transporter, solute receptor (TAXI family
OCU49_RS00760	COG1024	Enoyl-CoA hydratase
OCU49_RS00770	COG1024	Enoyl-CoA hydratase
OCU49_RS00775	COG1250	3-hydroxyacyl-CoA dehydrogenase
OCU49_RS00780	COG1024	Enoyl-CoA hydratase
OCU49_RS00785	COG1511	domain protein
OCU49_RS00785	COG3264	Mechanosensitive ion channel
OCU49_RS00810	COG0708	Exodeoxyribonuclease III
OCU49_RS00835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OCU49_RS00845	COG2814	Major facilitator Superfamily
OCU49_RS00970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
OCU49_RS00975	COG0735	belongs to the Fur family
OCU49_RS00980	COG1121	(ABC) transporter
OCU49_RS00985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OCU49_RS00990	COG0697	spore germination
OCU49_RS01000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OCU49_RS01005	COG0572	uridine kinase
OCU49_RS01010	COG2373	Large extracellular alpha-helical protein
OCU49_RS01015	COG4953	penicillin-binding protein 1C
OCU49_RS01020	COG4977	sequence-specific DNA binding
OCU49_RS01020	COG1917	Cupin 2, conserved barrel domain protein
OCU49_RS01035	COG0840	transmembrane signaling receptor activity
OCU49_RS01055	COG2205	protein histidine kinase activity
OCU49_RS01060	COG2818	Glycosylase
OCU49_RS01075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OCU49_RS01085	COG0745	RESPONSE REGULATOR receiver
OCU49_RS01090	COG2205	protein histidine kinase activity
OCU49_RS01095	COG4452	Inner membrane protein CreD
OCU49_RS01105	COG0501	Belongs to the peptidase M48B family
OCU49_RS01140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
OCU49_RS01145	COG4181	ATPase activity
OCU49_RS01160	COG0583	DNA-binding transcription factor activity
OCU49_RS01165	COG1160	GTP binding
OCU49_RS01190	COG0678	peroxiredoxin activity
OCU49_RS01190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OCU49_RS01195	COG1760	l-serine dehydratase
OCU49_RS01215	COG4176	ABC-type proline glycine betaine transport system permease component
OCU49_RS01230	COG0583	DNA-binding transcription factor activity
OCU49_RS01245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS01245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS01250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS01255	COG3383	formate dehydrogenase (NAD+) activity
OCU49_RS01265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS01270	COG0251	oxidation-reduction process
OCU49_RS01280	COG0733	neurotransmitter:sodium symporter activity
OCU49_RS01305	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
OCU49_RS01310	COG5001	Diguanylate cyclase
OCU49_RS01310	COG3706	GGDEF domain
OCU49_RS01310	COG2203	Gaf domain
OCU49_RS01310	COG4251	negative regulation of phosphorylation
OCU49_RS01340	COG5002	protein histidine kinase activity
OCU49_RS01385	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS01385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS01390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS01405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OCU49_RS01415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OCU49_RS01450	COG0494	nUDIX hydrolase
OCU49_RS01455	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS01465	COG0583	DNA-binding transcription factor activity
OCU49_RS01480	COG0840	transmembrane signaling receptor activity
OCU49_RS01485	COG0583	DNA-binding transcription factor activity
OCU49_RS01490	COG5598	trimethylamine methyltransferase
OCU49_RS01500	COG2252	PERMEase
OCU49_RS01510	COG3360	Dodecin
OCU49_RS01535	COG1760	l-serine dehydratase
OCU49_RS01560	COG0390	transport system, permease component
OCU49_RS01565	COG2217	Heavy metal translocating P-type atpase
OCU49_RS01575	COG0789	Transcriptional regulator
OCU49_RS01585	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS01595	COG0011	TIGRFAM Protein of
OCU49_RS01615	COG2313	pseudouridylate synthase activity
OCU49_RS01620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OCU49_RS01620	COG1522	sequence-specific DNA binding
OCU49_RS01625	COG1522	sequence-specific DNA binding
OCU49_RS01630	COG0010	Belongs to the arginase family
OCU49_RS01645	COG1522	sequence-specific DNA binding
OCU49_RS01660	COG1653	transport
OCU49_RS01680	COG0069	glutamate synthase activity
OCU49_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS01700	COG4948	Mandelate Racemase Muconate Lactonizing
OCU49_RS01730	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS01740	COG4948	Mandelate Racemase Muconate Lactonizing
OCU49_RS01765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCU49_RS01770	COG1132	(ABC) transporter
OCU49_RS01790	COG0583	DNA-binding transcription factor activity
OCU49_RS01795	COG0583	DNA-binding transcription factor activity
OCU49_RS01800	COG0803	Belongs to the bacterial solute-binding protein 9 family
OCU49_RS01805	COG1121	(ABC) transporter
OCU49_RS01810	COG1321	iron dependent repressor
OCU49_RS01810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OCU49_RS01815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OCU49_RS01830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OCU49_RS01845	COG0513	Belongs to the DEAD box helicase family
OCU49_RS01850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OCU49_RS01855	COG2154	pterin-4-alpha-carbinolamine dehydratase
OCU49_RS01870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OCU49_RS01875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OCU49_RS01910	COG1309	transcriptional regulator
OCU49_RS01930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OCU49_RS01935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OCU49_RS01940	COG0501	Belongs to the peptidase M48B family
OCU49_RS01945	COG0742	ribosomal rna small subunit methyltransferase
OCU49_RS01955	COG0552	protein localization to endoplasmic reticulum
OCU49_RS01960	COG2884	Cell division ATP-binding protein ftsE
OCU49_RS01965	COG2177	Part of the ABC transporter FtsEX involved in
OCU49_RS01975	COG2363	Small membrane protein
OCU49_RS01990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OCU49_RS01995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OCU49_RS02000	COG2379	hydroxypyruvate reductase
OCU49_RS02005	COG3437	response regulator, receiver
OCU49_RS02005	COG2770	Histidine kinase
OCU49_RS02010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
OCU49_RS02040	COG0501	Belongs to the peptidase M48B family
OCU49_RS02045	COG4269	membrane
OCU49_RS02050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OCU49_RS02050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
OCU49_RS02060	COG0306	phosphate transporter
OCU49_RS02065	COG1392	Phosphate transport regulator
OCU49_RS02070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
OCU49_RS02080	COG0626	cystathionine gamma-synthase activity
OCU49_RS02085	COG2814	Major facilitator Superfamily
OCU49_RS02090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS02095	COG1250	3-hydroxyacyl-CoA dehydrogenase
OCU49_RS02095	COG0824	Thioesterase
OCU49_RS02100	COG1960	acyl-CoA dehydrogenase activity
OCU49_RS02120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OCU49_RS02125	COG2194	sulfuric ester hydrolase activity
OCU49_RS02135	COG0859	PFAM glycosyl transferase family 9
OCU49_RS02140	COG0859	PFAM glycosyl transferase family 9
OCU49_RS02145	COG0438	transferase activity, transferring glycosyl groups
OCU49_RS02155	COG0438	transferase activity, transferring glycosyl groups
OCU49_RS02175	COG0463	Glycosyl transferase, family 2
OCU49_RS02180	COG1560	Kdo2-lipid A biosynthetic process
OCU49_RS02185	COG1132	(ABC) transporter
OCU49_RS02200	COG0667	Aldo Keto reductase
OCU49_RS02210	COG1519	Transferase
OCU49_RS02215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OCU49_RS02220	COG1965	Belongs to the frataxin family
OCU49_RS02240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OCU49_RS02250	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
OCU49_RS02255	COG1011	Hydrolase
OCU49_RS02275	COG0494	nUDIX hydrolase
OCU49_RS02280	COG1011	Hydrolase
OCU49_RS02285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OCU49_RS02290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OCU49_RS02295	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OCU49_RS02320	COG2986	histidine ammonia-lyase
OCU49_RS02355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OCU49_RS02375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OCU49_RS02390	COG0315	cyclic pyranopterin monophosphate synthase activity
OCU49_RS02400	COG1983	PspC domain protein
OCU49_RS02410	COG1842	Phage shock protein A
OCU49_RS02415	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OCU49_RS02425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OCU49_RS02430	COG0142	geranyltranstransferase activity
OCU49_RS02435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OCU49_RS02440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OCU49_RS02445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OCU49_RS02450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OCU49_RS02455	COG0268	Binds directly to 16S ribosomal RNA
OCU49_RS02460	COG0728	peptidoglycan biosynthetic process
OCU49_RS02465	COG0196	riboflavin kinase activity
OCU49_RS02470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OCU49_RS02475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OCU49_RS02480	COG1047	Peptidyl-prolyl cis-trans
OCU49_RS02510	COG4969	Belongs to the N-Me-Phe pilin family
OCU49_RS02590	COG0583	DNA-binding transcription factor activity
OCU49_RS02595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OCU49_RS02600	COG2207	Transcriptional regulator
OCU49_RS02615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OCU49_RS02620	COG1120	ATPase activity
OCU49_RS02635	COG2207	Transcriptional regulator
OCU49_RS02650	COG0583	DNA-binding transcription factor activity
OCU49_RS02655	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
OCU49_RS02665	COG4974	Belongs to the 'phage' integrase family
OCU49_RS02765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OCU49_RS02770	COG2867	negative regulation of translational initiation
OCU49_RS02785	COG0735	belongs to the Fur family
OCU49_RS02790	COG0497	DNA recombination
OCU49_RS02795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OCU49_RS02800	COG0443	Heat shock 70 kDa protein
OCU49_RS02810	COG1045	serine acetyltransferase
OCU49_RS02815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OCU49_RS02835	COG0494	nUDIX hydrolase
OCU49_RS02845	COG4536	flavin adenine dinucleotide binding
OCU49_RS02855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OCU49_RS02860	COG0228	four-way junction DNA binding
OCU49_RS02865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OCU49_RS02875	COG0335	large ribosomal subunit rRNA binding
OCU49_RS02885	COG4974	Belongs to the 'phage' integrase family
OCU49_RS02890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OCU49_RS02910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OCU49_RS02920	COG0840	transmembrane signaling receptor activity
OCU49_RS02925	COG2200	EAL domain
OCU49_RS02930	COG0494	nUDIX hydrolase
OCU49_RS02975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OCU49_RS02980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OCU49_RS02990	COG0069	glutamate synthase activity
OCU49_RS02990	COG0067	glutamate synthase
OCU49_RS02990	COG0070	glutamate synthase
OCU49_RS02995	COG0493	'glutamate synthase
OCU49_RS03000	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OCU49_RS03005	COG0288	reversible hydration of carbon dioxide
OCU49_RS03015	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OCU49_RS03025	COG0488	(ABC) transporter
OCU49_RS03030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OCU49_RS03035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OCU49_RS03035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OCU49_RS03050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OCU49_RS03055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OCU49_RS03060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OCU49_RS03065	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OCU49_RS03090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OCU49_RS03100	COG0142	geranyltranstransferase activity
OCU49_RS03110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OCU49_RS03115	COG1360	Flagellar Motor Protein
OCU49_RS03145	COG0745	RESPONSE REGULATOR receiver
OCU49_RS03150	COG0643	Histidine kinase
OCU49_RS03150	COG2198	Histidine kinase
OCU49_RS03155	COG0835	chemotaxis
OCU49_RS03170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OCU49_RS03175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
OCU49_RS03185	COG0840	transmembrane signaling receptor activity
OCU49_RS03195	COG0745	RESPONSE REGULATOR receiver
OCU49_RS03200	COG2113	Glycine betaine
OCU49_RS03205	COG3713	MltA-interacting MipA family protein
OCU49_RS03210	COG0642	Histidine kinase
OCU49_RS03255	COG3181	Tripartite tricarboxylate transporter family receptor
OCU49_RS03260	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS03265	COG0318	PFAM AMP-dependent synthetase and ligase
OCU49_RS03275	COG0583	DNA-binding transcription factor activity
OCU49_RS03300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS03305	COG0583	DNA-binding transcription factor activity
OCU49_RS03335	COG2226	methyltransferase
OCU49_RS03340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OCU49_RS03350	COG1393	Belongs to the ArsC family
OCU49_RS03355	COG0436	Aminotransferase
OCU49_RS03375	COG2267	carboxylic ester hydrolase activity
OCU49_RS03385	COG3008	intermembrane lipid transfer
OCU49_RS03390	COG2995	paraquat-inducible protein a
OCU49_RS03395	COG2995	paraquat-inducible protein a
OCU49_RS03405	COG1047	Peptidyl-prolyl cis-trans
OCU49_RS03435	COG0716	FMN binding
OCU49_RS03475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OCU49_RS03535	COG1196	nuclear chromosome segregation
OCU49_RS03625	COG2204	response regulator
OCU49_RS03645	COG0681	Belongs to the peptidase S26 family
OCU49_RS03705	COG0629	single-stranded DNA binding
OCU49_RS03725	COG0714	Associated with various cellular activities
OCU49_RS03750	COG2003	Belongs to the UPF0758 family
OCU49_RS03775	COG0443	Heat shock 70 kDa protein
OCU49_RS03780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OCU49_RS03860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OCU49_RS03865	COG0084	hydrolase, TatD family'
OCU49_RS03875	COG0784	Response regulator, receiver
OCU49_RS03875	COG2205	protein histidine kinase activity
OCU49_RS03880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OCU49_RS03890	COG2885	chlorophyll binding
OCU49_RS03920	COG0024	Methionine aminopeptidase
OCU49_RS03925	COG0052	Belongs to the universal ribosomal protein uS2 family
OCU49_RS03930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OCU49_RS03935	COG0528	UMP kinase activity
OCU49_RS03940	COG0233	cytoplasmic translational termination
OCU49_RS03945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OCU49_RS03950	COG0575	Belongs to the CDS family
OCU49_RS03970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OCU49_RS03975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OCU49_RS03980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OCU49_RS03995	COG0587	DNA-directed DNA polymerase activity
OCU49_RS04000	COG0825	malonyl-CoA metabolic process
OCU49_RS04005	COG0037	tRNA processing
OCU49_RS04015	COG0148	phosphopyruvate hydratase activity
OCU49_RS04020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
OCU49_RS04025	COG0585	pseudouridine synthase activity
OCU49_RS04030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OCU49_RS04035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
OCU49_RS04060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OCU49_RS04065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OCU49_RS04085	COG4191	Histidine kinase
OCU49_RS04095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OCU49_RS04100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OCU49_RS04105	COG0436	Aminotransferase
OCU49_RS04110	COG1489	DNA binding
OCU49_RS04130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OCU49_RS04140	COG2010	Cytochrome c
OCU49_RS04155	COG1845	cytochrome c oxidase, subunit III
OCU49_RS04165	COG0714	Associated with various cellular activities
OCU49_RS04175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OCU49_RS04175	COG1648	precorrin-2 dehydrogenase activity
OCU49_RS04180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OCU49_RS04180	COG1648	precorrin-2 dehydrogenase activity
OCU49_RS04210	COG0535	radical SAM domain protein
OCU49_RS04220	COG2010	Cytochrome c
OCU49_RS04230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OCU49_RS04250	COG1283	sodium-dependent phosphate transmembrane transporter activity
OCU49_RS04255	COG4172	Belongs to the ABC transporter superfamily
OCU49_RS04260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OCU49_RS04275	COG0583	DNA-binding transcription factor activity
OCU49_RS04285	COG3220	belongs to the UPF0276 family
OCU49_RS04305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OCU49_RS04310	COG0352	thiamine-phosphate diphosphorylase activity
OCU49_RS04315	COG0038	chloride channel
OCU49_RS04320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OCU49_RS04325	COG0316	Belongs to the HesB IscA family
OCU49_RS04335	COG0739	heme binding
OCU49_RS04365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OCU49_RS04370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OCU49_RS04385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OCU49_RS04385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
OCU49_RS04390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OCU49_RS04395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OCU49_RS04400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OCU49_RS04400	COG2755	lipolytic protein G-D-S-L family
OCU49_RS04415	COG0358	DNA primase activity
OCU49_RS04425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OCU49_RS04430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OCU49_RS04435	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OCU49_RS04440	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OCU49_RS04445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OCU49_RS04445	COG0302	gtp cyclohydrolase
OCU49_RS04450	COG1704	LemA family
OCU49_RS04455	COG0501	Belongs to the peptidase M48B family
OCU49_RS04465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OCU49_RS04470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OCU49_RS04475	COG2967	ApaG domain
OCU49_RS04480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OCU49_RS04485	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
OCU49_RS04495	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OCU49_RS04505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
OCU49_RS04510	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OCU49_RS04520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OCU49_RS04525	COG0546	phosphoglycolate phosphatase activity
OCU49_RS04530	COG0523	cobalamin synthesis protein
OCU49_RS04550	COG1846	Transcriptional regulator
OCU49_RS04565	COG4175	Glycine betaine
OCU49_RS04565	COG0517	IMP dehydrogenase activity
OCU49_RS04570	COG0583	DNA-binding transcription factor activity
OCU49_RS04575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCU49_RS04585	COG2133	pyrroloquinoline quinone binding
OCU49_RS04590	COG2346	COG2346, Truncated hemoglobins
OCU49_RS04605	COG1053	succinate dehydrogenase
OCU49_RS04605	COG3976	FMN-binding domain protein
OCU49_RS04620	COG4948	Mandelate Racemase Muconate Lactonizing
OCU49_RS04625	COG0583	DNA-binding transcription factor activity
OCU49_RS04645	COG0006	proline dipeptidase activity
OCU49_RS04650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
OCU49_RS04690	COG0583	DNA-binding transcription factor activity
OCU49_RS04695	COG0251	oxidation-reduction process
OCU49_RS04725	COG4115	mRNA cleavage
OCU49_RS04730	COG1396	sequence-specific DNA binding
OCU49_RS04735	COG1063	alcohol dehydrogenase
OCU49_RS04740	COG0156	8-amino-7-oxononanoate synthase activity
OCU49_RS04785	COG3781	membrane
OCU49_RS04795	COG0512	Glutamine amidotransferase of anthranilate synthase
OCU49_RS04800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OCU49_RS04805	COG0134	indole-3-glycerol-phosphate synthase activity
OCU49_RS04810	COG1765	OsmC-like protein
OCU49_RS04820	COG0360	Binds together with S18 to 16S ribosomal RNA
OCU49_RS04825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OCU49_RS04830	COG0359	binds to the 23S rRNA
OCU49_RS04835	COG0305	Participates in initiation and elongation during chromosome replication
OCU49_RS04865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OCU49_RS04880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OCU49_RS04885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OCU49_RS04895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OCU49_RS04900	COG0768	penicillin binding
OCU49_RS04905	COG0772	Belongs to the SEDS family
OCU49_RS04910	COG2951	lytic endotransglycosylase activity
OCU49_RS04920	COG1686	Belongs to the peptidase S11 family
OCU49_RS04930	COG2921	Belongs to the UPF0250 family
OCU49_RS04935	COG0321	lipoyl(octanoyl) transferase activity
OCU49_RS04960	COG1466	dna polymerase III delta subunit
OCU49_RS04970	COG0495	leucyl-tRNA aminoacylation
OCU49_RS04980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
OCU49_RS04985	COG4535	Mg2 and Co2 transporter CorC
OCU49_RS04990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OCU49_RS04995	COG1702	phosphate starvation-inducible protein PhoH
OCU49_RS05000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OCU49_RS05010	COG5002	protein histidine kinase activity
OCU49_RS05010	COG5001	Diguanylate cyclase
OCU49_RS05015	COG1509	lysine 2,3-aminomutase activity
OCU49_RS05020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OCU49_RS05025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
OCU49_RS05030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OCU49_RS05035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OCU49_RS05070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OCU49_RS05080	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS05085	COG1177	transmembrane transport
OCU49_RS05090	COG1176	ABC-type spermidine putrescine transport system, permease component I
OCU49_RS05100	COG3842	ATPase activity
OCU49_RS05105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS05110	COG0415	Belongs to the DNA photolyase family
OCU49_RS05120	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
OCU49_RS05135	COG2153	protein acetylation
OCU49_RS05165	COG1115	amino acid carrier protein
OCU49_RS05170	COG0488	(ABC) transporter
OCU49_RS05175	COG3148	PFAM DTW domain containing protein
OCU49_RS05185	COG5598	trimethylamine methyltransferase
OCU49_RS05195	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS05210	COG0702	epimerase
OCU49_RS05220	COG2944	sequence-specific DNA binding
OCU49_RS05225	COG0765	amino acid transport
OCU49_RS05230	COG0765	amino acid transport
OCU49_RS05235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OCU49_RS05245	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OCU49_RS05250	COG0583	DNA-binding transcription factor activity
OCU49_RS05285	COG0525	valine-tRNA ligase activity
OCU49_RS05300	COG0795	lipopolysaccharide-transporting ATPase activity
OCU49_RS05305	COG0795	lipopolysaccharide-transporting ATPase activity
OCU49_RS05315	COG2391	methyltransferase activity
OCU49_RS05345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
OCU49_RS05350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OCU49_RS05360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OCU49_RS05365	COG0697	spore germination
OCU49_RS05370	COG0583	DNA-binding transcription factor activity
OCU49_RS05375	COG1757	Na H antiporter
OCU49_RS05395	COG0688	phosphatidylethanolamine metabolic process
OCU49_RS05410	COG1162	GTPase activity
OCU49_RS05415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
OCU49_RS05420	COG0840	transmembrane signaling receptor activity
OCU49_RS05430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OCU49_RS05430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OCU49_RS05435	COG0802	atpase or kinase
OCU49_RS05440	COG0860	N-Acetylmuramoyl-L-alanine amidase
OCU49_RS05445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OCU49_RS05450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OCU49_RS05460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OCU49_RS05465	COG0330	HflC and HflK could
OCU49_RS05470	COG0330	HflC and HflK could
OCU49_RS05480	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
OCU49_RS05485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OCU49_RS05505	COG1104	cysteine desulfurase activity
OCU49_RS05510	COG0822	iron-sulfur transferase activity
OCU49_RS05515	COG0316	Belongs to the HesB IscA family
OCU49_RS05520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
OCU49_RS05540	COG0105	UTP biosynthetic process
OCU49_RS05545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OCU49_RS05560	COG0124	histidyl-tRNA synthetase
OCU49_RS05565	COG2976	Protein conserved in bacteria
OCU49_RS05575	COG1160	GTP binding
OCU49_RS05610	COG1335	isochorismatase
OCU49_RS05620	COG1473	amidohydrolase
OCU49_RS05625	COG0697	spore germination
OCU49_RS05640	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
OCU49_RS05665	COG3086	response to oxidative stress
OCU49_RS05670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OCU49_RS05675	COG0481	GTPase activity
OCU49_RS05680	COG0681	Belongs to the peptidase S26 family
OCU49_RS05690	COG0571	ribonuclease III activity
OCU49_RS05695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OCU49_RS05705	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
OCU49_RS05710	COG0736	holo-[acyl-carrier-protein] synthase activity
OCU49_RS05720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OCU49_RS05725	COG3956	TIGRFAM MazG family protein
OCU49_RS05735	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OCU49_RS05740	COG0563	adenylate kinase activity
OCU49_RS05745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OCU49_RS05750	COG4597	amino acid ABC transporter
OCU49_RS05755	COG0765	amino acid transport
OCU49_RS05760	COG1126	abc transporter atp-binding protein
OCU49_RS05765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OCU49_RS05770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OCU49_RS05775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OCU49_RS05785	COG0537	adenosine 5'-monophosphoramidase activity
OCU49_RS05790	COG2719	SpoVR family
OCU49_RS05795	COG2718	Belongs to the UPF0229 family
OCU49_RS05800	COG2766	serine protein kinase
OCU49_RS05840	COG2350	Protein conserved in bacteria
OCU49_RS05845	COG2917	probably involved in intracellular septation
OCU49_RS05855	COG0009	L-threonylcarbamoyladenylate synthase
OCU49_RS05870	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS05875	COG0546	phosphoglycolate phosphatase activity
OCU49_RS05890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
OCU49_RS05900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OCU49_RS05905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OCU49_RS05920	COG0776	regulation of translation
OCU49_RS05930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
OCU49_RS05940	COG1555	photosystem II stabilization
OCU49_RS05950	COG3220	belongs to the UPF0276 family
OCU49_RS05970	COG1720	tRNA m6t6A37 methyltransferase activity
OCU49_RS05975	COG1040	competence protein
OCU49_RS06000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
OCU49_RS06015	COG0596	Alpha beta hydrolase
OCU49_RS06020	COG0545	Peptidyl-prolyl cis-trans isomerase
OCU49_RS06025	COG1570	exodeoxyribonuclease VII activity
OCU49_RS06040	COG0590	tRNA wobble adenosine to inosine editing
OCU49_RS06050	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
OCU49_RS06065	COG0151	Belongs to the GarS family
OCU49_RS06070	COG0138	bifunctional purine biosynthesis protein purh
OCU49_RS06080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OCU49_RS06090	COG2264	protein methyltransferase activity
OCU49_RS06105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OCU49_RS06115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OCU49_RS06125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OCU49_RS06130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OCU49_RS06135	COG0154	amidase activity
OCU49_RS06140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OCU49_RS06145	COG1077	Cell shape determining protein MreB Mrl
OCU49_RS06150	COG1792	Involved in formation and maintenance of cell shape
OCU49_RS06155	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
OCU49_RS06160	COG0424	maF-like protein
OCU49_RS06175	COG3028	Belongs to the UPF0307 family
OCU49_RS06180	COG2239	Acts as a magnesium transporter
OCU49_RS06190	COG1660	Displays ATPase and GTPase activities
OCU49_RS06210	COG1137	ATPase activity
OCU49_RS06225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OCU49_RS06240	COG1127	ABC transporter
OCU49_RS06245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OCU49_RS06250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
OCU49_RS06265	COG5007	Belongs to the BolA IbaG family
OCU49_RS06270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OCU49_RS06275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OCU49_RS06280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OCU49_RS06290	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS06295	COG3030	protein affecting phage T7 exclusion by the F plasmid
OCU49_RS06305	COG0459	protein refolding
OCU49_RS06310	COG0643	Histidine kinase
OCU49_RS06310	COG0784	Response regulator, receiver
OCU49_RS06310	COG2198	Histidine kinase
OCU49_RS06315	COG0824	Thioesterase
OCU49_RS06315	COG1250	3-hydroxyacyl-CoA dehydrogenase
OCU49_RS06320	COG3246	L-lysine catabolic process to acetate
OCU49_RS06330	COG2194	sulfuric ester hydrolase activity
OCU49_RS06335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OCU49_RS06350	COG0175	sulfate reduction
OCU49_RS06355	COG0730	response to heat
OCU49_RS06360	COG0175	sulfate reduction
OCU49_RS06370	COG0745	RESPONSE REGULATOR receiver
OCU49_RS06390	COG0204	Acyl-transferase
OCU49_RS06395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OCU49_RS06400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OCU49_RS06450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OCU49_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS06465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OCU49_RS06470	COG2962	Rard protein
OCU49_RS06475	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
OCU49_RS06480	COG1522	sequence-specific DNA binding
OCU49_RS06485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OCU49_RS06495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OCU49_RS06505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OCU49_RS06515	COG0205	6-phosphofructokinase activity
OCU49_RS06550	COG0004	ammonium transporteR
OCU49_RS06555	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
OCU49_RS06560	COG3148	PFAM DTW domain containing protein
OCU49_RS06580	COG0277	FAD linked oxidase domain protein
OCU49_RS06585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS06595	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OCU49_RS06600	COG2186	Transcriptional regulator
OCU49_RS06610	COG0508	dehydrogenase complex catalyzes the overall conversion of
OCU49_RS06625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OCU49_RS06630	COG0166	Belongs to the GPI family
OCU49_RS06635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OCU49_RS06645	COG0521	Mo-molybdopterin cofactor biosynthetic process
OCU49_RS06650	COG0303	'Molybdopterin
OCU49_RS06660	COG0746	molybdenum cofactor guanylyltransferase activity
OCU49_RS06665	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
OCU49_RS06670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OCU49_RS06680	COG0723	plastoquinol--plastocyanin reductase activity
OCU49_RS06685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OCU49_RS06690	COG2857	Cytochrome c1
OCU49_RS06695	COG0625	glutathione transferase activity
OCU49_RS06700	COG2969	positive regulation of protein catabolic process
OCU49_RS06705	COG2823	Periplasmic or secreted lipoprotein
OCU49_RS06710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OCU49_RS06715	COG0792	nuclease activity
OCU49_RS06750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OCU49_RS06755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OCU49_RS06760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OCU49_RS06770	COG3100	YcgL domain-containing protein
OCU49_RS06775	COG2983	Belongs to the UPF0260 family
OCU49_RS06780	COG0737	Belongs to the 5'-nucleotidase family
OCU49_RS06795	COG2001	Belongs to the MraZ family
OCU49_RS06800	COG0275	rRNA processing
OCU49_RS06815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OCU49_RS06820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OCU49_RS06825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OCU49_RS06830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OCU49_RS06835	COG0772	Belongs to the SEDS family
OCU49_RS06840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OCU49_RS06845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OCU49_RS06870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
OCU49_RS06875	COG0653	protein targeting
OCU49_RS06880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OCU49_RS06885	COG0352	thiamine-phosphate diphosphorylase activity
OCU49_RS06890	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
OCU49_RS06895	COG0237	dephospho-CoA kinase activity
OCU49_RS06900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OCU49_RS06935	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
OCU49_RS06940	COG0732	type I restriction modification DNA specificity domain
OCU49_RS06945	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
OCU49_RS06950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OCU49_RS07010	COG3023	N-Acetylmuramoyl-L-alanine amidase
OCU49_RS07015	COG3842	ATPase activity
OCU49_RS07020	COG1178	ABC-type Fe3 transport system permease component
OCU49_RS07025	COG1840	ABC-type Fe3 transport system, periplasmic component
OCU49_RS07045	COG0534	Mate efflux family protein
OCU49_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS07060	COG3012	SEC-C Motif Domain Protein
OCU49_RS07065	COG2925	Exonuclease
OCU49_RS07095	COG3022	response to hydroperoxide
OCU49_RS07110	COG0180	Tryptophanyl-tRNA synthetase
OCU49_RS07120	COG2837	iron assimilation
OCU49_RS07125	COG2203	Gaf domain
OCU49_RS07125	COG2199	diguanylate cyclase activity
OCU49_RS07130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OCU49_RS07150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OCU49_RS07155	COG0748	coenzyme F420 binding
OCU49_RS07185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OCU49_RS07190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OCU49_RS07195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OCU49_RS07200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OCU49_RS07205	COG4660	Part of a membrane complex involved in electron transport
OCU49_RS07210	COG4659	FMN binding
OCU49_RS07215	COG4658	electron transport chain
OCU49_RS07225	COG2878	Part of a membrane complex involved in electron transport
OCU49_RS07230	COG4657	Part of a membrane complex involved in electron transport
OCU49_RS07235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OCU49_RS07245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OCU49_RS07245	COG1648	precorrin-2 dehydrogenase activity
OCU49_RS07250	COG2267	carboxylic ester hydrolase activity
OCU49_RS07255	COG2827	Endonuclease containing a URI domain
OCU49_RS07265	COG0348	domain, Protein
OCU49_RS07270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS07275	COG0418	dihydroorotase activity
OCU49_RS07280	COG0252	asparaginase activity
OCU49_RS07305	COG4181	ATPase activity
OCU49_RS07320	COG1686	Belongs to the peptidase S11 family
OCU49_RS07330	COG0436	Aminotransferase
OCU49_RS07335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OCU49_RS07355	COG1643	Atp-dependent helicase
OCU49_RS07365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS07370	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS07395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCU49_RS07410	COG0697	spore germination
OCU49_RS07415	COG0420	3'-5' exonuclease activity
OCU49_RS07420	COG0419	ATPase involved in DNA repair
OCU49_RS07475	COG0714	Associated with various cellular activities
OCU49_RS07495	COG2304	oxidoreductase activity
OCU49_RS07505	COG0778	Nitroreductase
OCU49_RS07515	COG1960	acyl-CoA dehydrogenase activity
OCU49_RS07520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OCU49_RS07525	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS07550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
OCU49_RS07565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OCU49_RS07570	COG0174	glutamine synthetase
OCU49_RS07575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS07595	COG2132	Multicopper oxidase
OCU49_RS07610	COG2358	TRAP transporter, solute receptor (TAXI family
OCU49_RS07620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS07635	COG0778	Nitroreductase
OCU49_RS07640	COG0697	spore germination
OCU49_RS07650	COG1335	isochorismatase
OCU49_RS07665	COG1741	Belongs to the pirin family
OCU49_RS07675	COG0435	Glutathione S-transferase
OCU49_RS07720	COG3226	Transcriptional regulator
OCU49_RS07750	COG0243	molybdopterin cofactor binding
OCU49_RS07755	COG2146	nitrite reductase [NAD(P)H] activity
OCU49_RS07760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OCU49_RS07760	COG2146	nitrite reductase [NAD(P)H] activity
OCU49_RS07765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OCU49_RS07770	COG0515	serine threonine protein kinase
OCU49_RS07770	COG2815	serine threonine protein kinase
OCU49_RS07775	COG2223	nitrite transmembrane transporter activity
OCU49_RS07780	COG3707	response regulator
OCU49_RS07785	COG0346	lactoylglutathione lyase activity
OCU49_RS07800	COG1984	allophanate hydrolase subunit 2
OCU49_RS07805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OCU49_RS07810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OCU49_RS07815	COG4336	lyase activity
OCU49_RS07840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OCU49_RS07845	COG3383	formate dehydrogenase (NAD+) activity
OCU49_RS07875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OCU49_RS07885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS07895	COG0174	glutamine synthetase
OCU49_RS07900	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS07945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS07950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OCU49_RS07955	COG1115	amino acid carrier protein
OCU49_RS07980	COG0583	DNA-binding transcription factor activity
OCU49_RS07985	COG1054	Belongs to the UPF0176 family
OCU49_RS07990	COG3706	GGDEF domain
OCU49_RS07990	COG4251	negative regulation of phosphorylation
OCU49_RS07990	COG5001	Diguanylate cyclase
OCU49_RS07990	COG2203	Gaf domain
OCU49_RS08010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
OCU49_RS08015	COG0583	DNA-binding transcription factor activity
OCU49_RS08050	COG0596	Alpha beta hydrolase
OCU49_RS08055	COG0583	DNA-binding transcription factor activity
OCU49_RS08070	COG1858	cytochrome C peroxidase
OCU49_RS08090	COG5001	Diguanylate cyclase
OCU49_RS08090	COG3300	MHYT domain
OCU49_RS08115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OCU49_RS08125	COG1228	amidohydrolase
OCU49_RS08130	COG0523	cobalamin synthesis protein
OCU49_RS08145	COG5001	Diguanylate cyclase
OCU49_RS08150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OCU49_RS08200	COG0010	Belongs to the arginase family
OCU49_RS08215	COG1166	arginine decarboxylase activity
OCU49_RS08220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCU49_RS08225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS08230	COG0686	Belongs to the AlaDH PNT family
OCU49_RS08240	COG0280	phosphate acetyltransferase
OCU49_RS08250	COG2197	response regulator
OCU49_RS08260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OCU49_RS08270	COG2261	transglycosylase associated protein
OCU49_RS08285	COG3152	Membrane
OCU49_RS08295	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OCU49_RS08305	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
OCU49_RS08305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OCU49_RS08315	COG0584	glycerophosphoryl diester phosphodiesterase
OCU49_RS08380	COG0159	tryptophan synthase activity
OCU49_RS08400	COG1902	pentaerythritol trinitrate reductase activity
OCU49_RS08400	COG0446	pyridine nucleotide-disulphide oxidoreductase
OCU49_RS08405	COG0006	proline dipeptidase activity
OCU49_RS08420	COG1132	(ABC) transporter
OCU49_RS08435	COG0037	tRNA processing
OCU49_RS08445	COG1024	Enoyl-CoA hydratase
OCU49_RS08465	COG3258	Cytochrome c
OCU49_RS08475	COG0737	Belongs to the 5'-nucleotidase family
OCU49_RS08540	COG2132	Multicopper oxidase
OCU49_RS08545	COG0745	RESPONSE REGULATOR receiver
OCU49_RS08550	COG5002	protein histidine kinase activity
OCU49_RS08580	COG3101	peptidyl-lysine hydroxylation
OCU49_RS08605	COG0023	Translation Initiation Factor
OCU49_RS08625	COG0584	glycerophosphoryl diester phosphodiesterase
OCU49_RS08635	COG3794	PFAM blue (type 1) copper domain protein
OCU49_RS08650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OCU49_RS08655	COG2954	triphosphatase activity
OCU49_RS08660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OCU49_RS08660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OCU49_RS08665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OCU49_RS08695	COG2974	May be involved in recombination
OCU49_RS08705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OCU49_RS08710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OCU49_RS08745	COG2010	Cytochrome c
OCU49_RS08760	COG3278	Belongs to the heme-copper respiratory oxidase family
OCU49_RS08770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
OCU49_RS08780	COG0425	Belongs to the sulfur carrier protein TusA family
OCU49_RS08790	COG3287	FIST C domain
OCU49_RS08790	COG2200	EAL domain
OCU49_RS08790	COG2199	diguanylate cyclase activity
OCU49_RS08810	COG3243	poly(R)-hydroxyalkanoic acid synthase
OCU49_RS08820	COG0084	hydrolase, TatD family'
OCU49_RS08825	COG0741	lytic transglycosylase activity
OCU49_RS08830	COG0488	(ABC) transporter
OCU49_RS08835	COG0589	response to stress
OCU49_RS08875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OCU49_RS08880	COG1199	ATP-dependent helicase activity
OCU49_RS08900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OCU49_RS08915	COG0596	Alpha beta hydrolase
OCU49_RS08940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OCU49_RS08955	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
OCU49_RS08965	COG1388	LysM domain
OCU49_RS08965	COG0741	lytic transglycosylase activity
OCU49_RS08970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OCU49_RS08975	COG1858	cytochrome C peroxidase
OCU49_RS08985	COG2010	Cytochrome c
OCU49_RS09000	COG2204	response regulator
OCU49_RS09010	COG0328	RNA-DNA hybrid ribonuclease activity
OCU49_RS09015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OCU49_RS09020	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OCU49_RS09025	COG2816	NAD+ diphosphatase activity
OCU49_RS09035	COG0616	signal peptide processing
OCU49_RS09050	COG1472	Belongs to the glycosyl hydrolase 3 family
OCU49_RS09055	COG0668	transmembrane transport
OCU49_RS09065	COG4977	sequence-specific DNA binding
OCU49_RS09065	COG1917	Cupin 2, conserved barrel domain protein
OCU49_RS09080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OCU49_RS09095	COG1805	sodium ion transport
OCU49_RS09105	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OCU49_RS09110	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
OCU49_RS09115	COG2871	sodium ion transport
OCU49_RS09120	COG1477	protein flavinylation
OCU49_RS09130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OCU49_RS09155	COG1136	(ABC) transporter
OCU49_RS09170	COG0811	peptide transport
OCU49_RS09175	COG0848	biopolymer transport protein
OCU49_RS09180	COG1663	tetraacyldisaccharide 4'-kinase activity
OCU49_RS09185	COG2835	tetraacyldisaccharide 4'-kinase activity
OCU49_RS09190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OCU49_RS09195	COG3813	Protein conserved in bacteria
OCU49_RS09200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OCU49_RS09205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OCU49_RS09210	COG1530	ribonuclease E activity
OCU49_RS09235	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS09240	COG1607	acyl-coa hydrolase
OCU49_RS09245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
OCU49_RS09255	COG1802	Transcriptional regulator
OCU49_RS09260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OCU49_RS09265	COG0372	Belongs to the citrate synthase family
OCU49_RS09280	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
OCU49_RS09300	COG3243	poly(R)-hydroxyalkanoic acid synthase
OCU49_RS09315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OCU49_RS09320	COG0066	3-isopropylmalate dehydratase activity
OCU49_RS09325	COG0473	3-isopropylmalate dehydrogenase activity
OCU49_RS09330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OCU49_RS09340	COG1522	sequence-specific DNA binding
OCU49_RS09350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OCU49_RS09355	COG0506	proline dehydrogenase activity
OCU49_RS09355	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OCU49_RS09355	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
OCU49_RS09365	COG1802	Transcriptional regulator
OCU49_RS09375	COG0579	oxidoreductase
OCU49_RS09405	COG0513	Belongs to the DEAD box helicase family
OCU49_RS09425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OCU49_RS09430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OCU49_RS09440	COG0628	permease
OCU49_RS09455	COG0564	pseudouridine synthase activity
OCU49_RS09465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OCU49_RS09470	COG3706	GGDEF domain
OCU49_RS09475	COG0583	DNA-binding transcription factor activity
OCU49_RS09485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OCU49_RS09500	COG1393	Belongs to the ArsC family
OCU49_RS09505	COG1295	ribonuclease BN
OCU49_RS09505	COG1959	2 iron, 2 sulfur cluster binding
OCU49_RS09515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OCU49_RS09530	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
OCU49_RS09540	COG1079	Belongs to the binding-protein-dependent transport system permease family
OCU49_RS09545	COG4603	Belongs to the binding-protein-dependent transport system permease family
OCU49_RS09550	COG3845	ABC transporter
OCU49_RS09565	COG0442	prolyl-tRNA aminoacylation
OCU49_RS09585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OCU49_RS09600	COG4566	intracellular signal transduction
OCU49_RS09605	COG4191	Histidine kinase
OCU49_RS09610	COG0318	PFAM AMP-dependent synthetase and ligase
OCU49_RS09620	COG4783	chaperone-mediated protein folding
OCU49_RS09625	COG0425	Belongs to the sulfur carrier protein TusA family
OCU49_RS09640	COG0583	DNA-binding transcription factor activity
OCU49_RS09645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
OCU49_RS09655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OCU49_RS09665	COG3112	Uncharacterised protein family (UPF0231)
OCU49_RS09670	COG0564	pseudouridine synthase activity
OCU49_RS09675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OCU49_RS09680	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
OCU49_RS09690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OCU49_RS09690	COG0475	glutathione-regulated potassium exporter activity
OCU49_RS09695	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OCU49_RS09695	COG0316	Belongs to the HesB IscA family
OCU49_RS09700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OCU49_RS09715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OCU49_RS09720	COG0583	DNA-binding transcription factor activity
OCU49_RS09730	COG1049	propionate catabolic process, 2-methylcitrate cycle
OCU49_RS09735	COG0217	transcriptional regulatory protein
OCU49_RS09740	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS09745	COG1794	racemase activity, acting on amino acids and derivatives
OCU49_RS09760	COG2081	HI0933 family
OCU49_RS09820	COG1320	monovalent cation:proton antiporter activity
OCU49_RS09830	COG1006	Multisubunit Na H antiporter MnhC subunit
OCU49_RS09835	COG0651	ATP synthesis coupled electron transport
OCU49_RS09840	COG0651	ATP synthesis coupled electron transport
OCU49_RS09850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
OCU49_RS09850	COG2111	Na H antiporter
OCU49_RS09870	COG3153	acetyltransferase
OCU49_RS09875	COG3811	Belongs to the UPF0386 family
OCU49_RS09880	COG1309	transcriptional regulator
OCU49_RS09885	COG0527	aspartate kinase activity
OCU49_RS09890	COG5285	phytanoyl-CoA dioxygenase
OCU49_RS09895	COG1917	Cupin 2, conserved barrel domain protein
OCU49_RS09910	COG1846	Transcriptional regulator
OCU49_RS09915	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS09920	COG1522	sequence-specific DNA binding
OCU49_RS09930	COG1917	Cupin 2, conserved barrel domain protein
OCU49_RS09930	COG2207	Transcriptional regulator
OCU49_RS09945	COG1944	ATP diphosphatase activity
OCU49_RS09960	COG1192	Involved in chromosome partitioning
OCU49_RS09990	COG0443	Heat shock 70 kDa protein
OCU49_RS09995	COG0826	peptidase U32
OCU49_RS10000	COG0826	peptidase U32
OCU49_RS10005	COG3154	lipid carrier protein
OCU49_RS10030	COG0235	Class ii aldolase
OCU49_RS10080	COG0583	DNA-binding transcription factor activity
OCU49_RS10090	COG0174	glutamine synthetase
OCU49_RS10095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS10110	COG0667	Aldo Keto reductase
OCU49_RS10115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OCU49_RS10125	COG2204	response regulator
OCU49_RS10135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OCU49_RS10160	COG2204	response regulator
OCU49_RS10185	COG1366	Belongs to the anti-sigma-factor antagonist family
OCU49_RS10190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OCU49_RS10200	COG0438	transferase activity, transferring glycosyl groups
OCU49_RS10230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OCU49_RS10255	COG0438	transferase activity, transferring glycosyl groups
OCU49_RS10265	COG3300	MHYT domain
OCU49_RS10265	COG5001	Diguanylate cyclase
OCU49_RS10285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OCU49_RS10320	COG2113	Glycine betaine
OCU49_RS10325	COG4176	ABC-type proline glycine betaine transport system permease component
OCU49_RS10330	COG4175	Glycine betaine
OCU49_RS10340	COG4638	Rieske (2fe-2S)
OCU49_RS10345	COG0583	DNA-binding transcription factor activity
OCU49_RS10350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OCU49_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS10370	COG0583	DNA-binding transcription factor activity
OCU49_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS10380	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS10395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OCU49_RS10400	COG2197	response regulator
OCU49_RS10410	COG2994	toxin metabolic process
OCU49_RS10420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCU49_RS10475	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS10485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OCU49_RS10495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OCU49_RS10505	COG1960	acyl-CoA dehydrogenase activity
OCU49_RS10510	COG0679	Auxin Efflux Carrier
OCU49_RS10520	COG3971	2-oxopent-4-enoate hydratase activity
OCU49_RS10530	COG0179	Fumarylacetoacetate (FAA) hydrolase
OCU49_RS10575	COG2814	Major facilitator Superfamily
OCU49_RS10585	COG3384	dioxygenase
OCU49_RS10595	COG3384	dioxygenase
OCU49_RS10605	COG4464	protein tyrosine phosphatase activity
OCU49_RS10610	COG0489	protein tyrosine kinase activity
OCU49_RS10645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OCU49_RS10650	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OCU49_RS10680	COG0297	glycogen (starch) synthase activity
OCU49_RS10680	COG0438	transferase activity, transferring glycosyl groups
OCU49_RS10695	COG1045	serine acetyltransferase
OCU49_RS10700	COG0110	maltose O-acetyltransferase activity
OCU49_RS10710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OCU49_RS10720	COG1088	dTDP-glucose 4,6-dehydratase activity
OCU49_RS10725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OCU49_RS10740	COG0583	DNA-binding transcription factor activity
OCU49_RS10745	COG4638	Rieske (2fe-2S)
OCU49_RS10760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OCU49_RS10785	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OCU49_RS10790	COG5001	Diguanylate cyclase
OCU49_RS10790	COG3300	MHYT domain
OCU49_RS10795	COG0583	DNA-binding transcription factor activity
OCU49_RS10805	COG0842	Transport permease protein
OCU49_RS10810	COG1131	(ABC) transporter
OCU49_RS10825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS10825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS10835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS10855	COG0653	protein targeting
OCU49_RS10860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
OCU49_RS10875	COG1278	Cold shock
OCU49_RS10900	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS10915	COG1473	amidohydrolase
OCU49_RS10920	COG0583	DNA-binding transcription factor activity
OCU49_RS10925	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS10940	COG2258	MOSC domain
OCU49_RS10945	COG0583	DNA-binding transcription factor activity
OCU49_RS10980	COG1017	nitric oxide dioxygenase activity
OCU49_RS10980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OCU49_RS10990	COG3604	Transcriptional regulator
OCU49_RS11005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OCU49_RS11050	COG1132	(ABC) transporter
OCU49_RS11055	COG2945	thiolester hydrolase activity
OCU49_RS11060	COG3634	alkyl hydroperoxide reductase activity
OCU49_RS11070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OCU49_RS11160	COG0515	serine threonine protein kinase
OCU49_RS11160	COG2815	serine threonine protein kinase
OCU49_RS11190	COG3858	chitin binding
OCU49_RS11190	COG1388	LysM domain
OCU49_RS11275	COG3209	COG3209 Rhs family protein
OCU49_RS11290	COG3209	COG3209 Rhs family protein
OCU49_RS11305	COG1333	cytochrome c biogenesis protein
OCU49_RS11320	COG0697	spore germination
OCU49_RS11335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS11350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS11355	COG2963	transposase activity
OCU49_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS11370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
OCU49_RS11390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OCU49_RS11395	COG0583	DNA-binding transcription factor activity
OCU49_RS11400	COG1027	Aspartate ammonia-lyase
OCU49_RS11405	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS11410	COG0697	spore germination
OCU49_RS11420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OCU49_RS11425	COG0583	DNA-binding transcription factor activity
OCU49_RS11450	COG0583	DNA-binding transcription factor activity
OCU49_RS11460	COG2226	methyltransferase
OCU49_RS11470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCU49_RS11485	COG2175	clavaminate synthase activity
OCU49_RS11495	COG1309	transcriptional regulator
OCU49_RS11505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OCU49_RS11565	COG3971	2-oxopent-4-enoate hydratase activity
OCU49_RS11575	COG0596	Alpha beta hydrolase
OCU49_RS11585	COG0148	phosphopyruvate hydratase activity
OCU49_RS11595	COG0469	pyruvate kinase activity
OCU49_RS11640	COG1086	Polysaccharide biosynthesis protein
OCU49_RS11650	COG1083	cytidylyl-transferase
OCU49_RS11660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OCU49_RS11665	COG2089	acid synthase
OCU49_RS11690	COG0156	8-amino-7-oxononanoate synthase activity
OCU49_RS11695	COG3321	synthase
OCU49_RS11695	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS11695	COG0604	alcohol dehydrogenase
OCU49_RS11725	COG0564	pseudouridine synthase activity
OCU49_RS11745	COG1566	PFAM secretion protein HlyD family protein
OCU49_RS11770	COG2850	peptidyl-arginine hydroxylation
OCU49_RS11785	COG0840	transmembrane signaling receptor activity
OCU49_RS11790	COG1858	cytochrome C peroxidase
OCU49_RS11805	COG4232	protein-disulfide reductase activity
OCU49_RS11810	COG0583	DNA-binding transcription factor activity
OCU49_RS11845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS11865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OCU49_RS11870	COG0583	DNA-binding transcription factor activity
OCU49_RS11875	COG0840	transmembrane signaling receptor activity
OCU49_RS11895	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
OCU49_RS11915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OCU49_RS11925	COG2814	Major facilitator Superfamily
OCU49_RS11930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OCU49_RS11945	COG1451	nucleotide metabolic process
OCU49_RS11950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS11975	COG3045	CreA protein
OCU49_RS11985	COG0583	DNA-binding transcription factor activity
OCU49_RS11990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCU49_RS11995	COG2873	o-acetylhomoserine
OCU49_RS12005	COG1024	Enoyl-CoA hydratase
OCU49_RS12005	COG1250	3-hydroxyacyl-CoA dehydrogenase
OCU49_RS12025	COG0583	DNA-binding transcription factor activity
OCU49_RS12030	COG0583	DNA-binding transcription factor activity
OCU49_RS12045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS12055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS12065	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OCU49_RS12070	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS12075	COG3604	Transcriptional regulator
OCU49_RS12080	COG0583	DNA-binding transcription factor activity
OCU49_RS12085	COG3321	synthase
OCU49_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS12085	COG0604	alcohol dehydrogenase
OCU49_RS12090	COG4948	Mandelate Racemase Muconate Lactonizing
OCU49_RS12095	COG0006	proline dipeptidase activity
OCU49_RS12130	COG2814	Major facilitator Superfamily
OCU49_RS12135	COG4264	IucA IucC family
OCU49_RS12140	COG0019	diaminopimelate decarboxylase activity
OCU49_RS12155	COG1595	DNA-templated transcription, initiation
OCU49_RS12165	COG4772	TonB-dependent receptor
OCU49_RS12170	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
OCU49_RS12175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCU49_RS12180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCU49_RS12185	COG1120	ATPase activity
OCU49_RS12200	COG0583	DNA-binding transcription factor activity
OCU49_RS12205	COG0604	alcohol dehydrogenase
OCU49_RS12205	COG3321	synthase
OCU49_RS12210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OCU49_RS12220	COG0513	Belongs to the DEAD box helicase family
OCU49_RS12235	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS12240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OCU49_RS12265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OCU49_RS12270	COG1459	type II secretion system
OCU49_RS12285	COG2165	general secretion pathway protein
OCU49_RS12295	COG3156	type II secretion system protein K
OCU49_RS12300	COG3166	PFAM Fimbrial assembly family protein
OCU49_RS12315	COG1450	Type ii and iii secretion system protein
OCU49_RS12340	COG2204	response regulator
OCU49_RS12345	COG3267	Type II secretory pathway component ExeA
OCU49_RS12345	COG3409	Peptidoglycan-binding domain 1 protein
OCU49_RS12610	COG2197	response regulator
OCU49_RS12625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OCU49_RS12630	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
OCU49_RS12640	COG4143	(ABC) transporter
OCU49_RS12735	COG4386	tail sheath protein
OCU49_RS12770	COG0616	signal peptide processing
OCU49_RS12785	COG4626	Terminase
OCU49_RS12785	COG1802	Transcriptional regulator
OCU49_RS12820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OCU49_RS12825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OCU49_RS12840	COG3039	Transposase
OCU49_RS12895	COG0629	single-stranded DNA binding
OCU49_RS12905	COG5532	Uncharacterized conserved protein (DUF2303)
OCU49_RS12930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OCU49_RS12960	COG0322	excinuclease ABC activity
OCU49_RS12980	COG2084	Dehydrogenase
OCU49_RS12985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OCU49_RS12990	COG0254	rRNA binding
OCU49_RS13000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OCU49_RS13010	COG0564	pseudouridine synthase activity
OCU49_RS13015	COG0670	Belongs to the BI1 family
OCU49_RS13020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
OCU49_RS13030	COG2168	tRNA wobble position uridine thiolation
OCU49_RS13035	COG2920	part of a sulfur-relay system
OCU49_RS13040	COG2084	Dehydrogenase
OCU49_RS13045	COG3622	Belongs to the hyi family
OCU49_RS13050	COG0835	chemotaxis
OCU49_RS13055	COG0840	transmembrane signaling receptor activity
OCU49_RS13060	COG0432	Pfam Uncharacterised protein family UPF0047
OCU49_RS13065	COG0697	spore germination
OCU49_RS13070	COG0583	DNA-binding transcription factor activity
OCU49_RS13075	COG0084	hydrolase, TatD family'
OCU49_RS13090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OCU49_RS13095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OCU49_RS13105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OCU49_RS13110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OCU49_RS13125	COG0416	fatty acid biosynthetic process
OCU49_RS13130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OCU49_RS13135	COG1399	metal-binding, possibly nucleic acid-binding protein
OCU49_RS13140	COG0424	maF-like protein
OCU49_RS13155	COG0546	phosphoglycolate phosphatase activity
OCU49_RS13160	COG1959	2 iron, 2 sulfur cluster binding
OCU49_RS13165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OCU49_RS13180	COG0247	lactate metabolic process
OCU49_RS13180	COG0277	FAD linked oxidase domain protein
OCU49_RS13185	COG0583	DNA-binding transcription factor activity
OCU49_RS13195	COG0697	spore germination
OCU49_RS13210	COG4628	conserved protein (DUF2132)
OCU49_RS13225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OCU49_RS13255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OCU49_RS13265	COG0300	oxidoreductase activity
OCU49_RS13270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OCU49_RS13275	COG1410	methionine synthase
OCU49_RS13275	COG0646	methionine synthase
OCU49_RS13280	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
OCU49_RS13290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OCU49_RS13310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OCU49_RS13315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OCU49_RS13320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OCU49_RS13325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OCU49_RS13330	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OCU49_RS13345	COG0492	ferredoxin-NADP+ reductase activity
OCU49_RS13350	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
OCU49_RS13355	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
OCU49_RS13360	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OCU49_RS13365	COG0542	response to heat
OCU49_RS13370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
OCU49_RS13375	COG1278	Cold shock
OCU49_RS13385	COG1187	pseudouridine synthase activity
OCU49_RS13390	COG0314	molybdopterin synthase activity
OCU49_RS13400	COG0482	sulfurtransferase activity
OCU49_RS13405	COG2915	High frequency lysogenization protein hflD homolog
OCU49_RS13420	COG5001	Diguanylate cyclase
OCU49_RS13420	COG2203	Gaf domain
OCU49_RS13420	COG3706	GGDEF domain
OCU49_RS13420	COG4251	negative regulation of phosphorylation
OCU49_RS13430	COG1252	NADH dehydrogenase
OCU49_RS13440	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OCU49_RS13445	COG0740	serine-type endopeptidase activity
OCU49_RS13450	COG0544	peptidyl-prolyl cis-trans isomerase activity
OCU49_RS13475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OCU49_RS13500	COG0215	cysteine-tRNA ligase activity
OCU49_RS13505	COG1528	Iron-storage protein
OCU49_RS13510	COG1607	acyl-coa hydrolase
OCU49_RS13515	COG0778	Nitroreductase
OCU49_RS13520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OCU49_RS13525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OCU49_RS13530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OCU49_RS13540	COG2832	Protein of unknown function (DUF454)
OCU49_RS13555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OCU49_RS13565	COG1286	toxin biosynthetic process
OCU49_RS13575	COG0285	dihydrofolate synthase activity
OCU49_RS13585	COG0159	tryptophan synthase activity
OCU49_RS13595	COG0135	phosphoribosylanthranilate isomerase activity
OCU49_RS13615	COG4977	sequence-specific DNA binding
OCU49_RS13620	COG2175	clavaminate synthase activity
OCU49_RS13625	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
OCU49_RS13630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
OCU49_RS13635	COG3639	organic phosphonate transmembrane transporter activity
OCU49_RS13675	COG0513	Belongs to the DEAD box helicase family
OCU49_RS13720	COG1840	ABC-type Fe3 transport system, periplasmic component
OCU49_RS13730	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OCU49_RS13735	COG0010	Belongs to the arginase family
OCU49_RS13750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OCU49_RS13770	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS13775	COG3724	N-succinylarginine dihydrolase activity
OCU49_RS13780	COG0384	phenazine biosynthesis protein PhzF
OCU49_RS13790	COG2197	response regulator
OCU49_RS13830	COG0019	diaminopimelate decarboxylase activity
OCU49_RS13855	COG0668	transmembrane transport
OCU49_RS13885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OCU49_RS13890	COG4638	Rieske (2fe-2S)
OCU49_RS13900	COG4191	Histidine kinase
OCU49_RS13900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OCU49_RS13905	COG3437	response regulator, receiver
OCU49_RS13905	COG0784	Response regulator, receiver
OCU49_RS13910	COG2072	flavoprotein involved in K transport
OCU49_RS13955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OCU49_RS13960	COG1113	amino acid transport
OCU49_RS13975	COG1902	pentaerythritol trinitrate reductase activity
OCU49_RS13985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCU49_RS13995	COG1120	ATPase activity
OCU49_RS14000	COG0351	phosphomethylpyrimidine kinase
OCU49_RS14005	COG1116	anion transmembrane transporter activity
OCU49_RS14010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCU49_RS14015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OCU49_RS14020	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OCU49_RS14030	COG0346	lactoylglutathione lyase activity
OCU49_RS14110	COG3437	response regulator, receiver
OCU49_RS14115	COG4191	Histidine kinase
OCU49_RS14130	COG0556	nucleotide-excision repair
OCU49_RS14135	COG0436	Aminotransferase
OCU49_RS14140	COG2989	Protein conserved in bacteria
OCU49_RS14155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
OCU49_RS14160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OCU49_RS14160	COG2169	Transcriptional regulator
OCU49_RS14170	COG3047	cAMP biosynthetic process
OCU49_RS14180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
OCU49_RS14185	COG0326	Molecular chaperone. Has ATPase activity
OCU49_RS14200	COG3038	cytochrome b561
OCU49_RS14210	COG0583	DNA-binding transcription factor activity
OCU49_RS14235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OCU49_RS14240	COG1074	ATP-dependent DNA helicase activity
OCU49_RS14245	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
OCU49_RS14265	COG0668	transmembrane transport
OCU49_RS14270	COG1960	acyl-CoA dehydrogenase activity
OCU49_RS14275	COG2030	dehydratase
OCU49_RS14285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
OCU49_RS14290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OCU49_RS14295	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
OCU49_RS14300	COG2885	chlorophyll binding
OCU49_RS14305	COG0823	Involved in the tonB-independent uptake of proteins
OCU49_RS14330	COG2255	four-way junction helicase activity
OCU49_RS14335	COG0632	four-way junction helicase activity
OCU49_RS14345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OCU49_RS14355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OCU49_RS14370	COG3706	GGDEF domain
OCU49_RS14380	COG0045	succinate-CoA ligase (ADP-forming) activity
OCU49_RS14400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OCU49_RS14410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
OCU49_RS14430	COG3130	regulation of translation
OCU49_RS14435	COG0167	dihydroorotate dehydrogenase activity
OCU49_RS14450	COG1090	epimerase
OCU49_RS14455	COG0307	riboflavin synthase, alpha
OCU49_RS14460	COG0579	oxidoreductase
OCU49_RS14465	COG0385	Bile acid
OCU49_RS14475	COG1739	Uncharacterized protein family UPF0029
OCU49_RS14480	COG3706	GGDEF domain
OCU49_RS14490	COG0708	Exodeoxyribonuclease III
OCU49_RS14495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCU49_RS14505	COG3448	diguanylate cyclase activity
OCU49_RS14505	COG4175	Glycine betaine
OCU49_RS14510	COG4176	ABC-type proline glycine betaine transport system permease component
OCU49_RS14515	COG1609	Transcriptional regulator
OCU49_RS14525	COG0589	response to stress
OCU49_RS14535	COG2193	ferroxidase activity
OCU49_RS14545	COG2906	2 iron, 2 sulfur cluster binding
OCU49_RS14565	COG0640	Transcriptional regulator
OCU49_RS14570	COG1042	CoA-binding domain protein
OCU49_RS14570	COG0045	succinate-CoA ligase (ADP-forming) activity
OCU49_RS14570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OCU49_RS14615	COG0133	tryptophan synthase activity
OCU49_RS14645	COG5001	Diguanylate cyclase
OCU49_RS14670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OCU49_RS14675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OCU49_RS14680	COG3616	Alanine racemase, N-terminal domain
OCU49_RS14685	COG2423	ornithine cyclodeaminase activity
OCU49_RS14690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OCU49_RS14710	COG4948	Mandelate Racemase Muconate Lactonizing
OCU49_RS14740	COG0714	Associated with various cellular activities
OCU49_RS14755	COG2205	protein histidine kinase activity
OCU49_RS14765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OCU49_RS14775	COG1469	GTP cyclohydrolase I activity
OCU49_RS14780	COG0583	DNA-binding transcription factor activity
OCU49_RS14785	COG0693	protein deglycase activity
OCU49_RS14790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OCU49_RS14810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OCU49_RS14830	COG3706	GGDEF domain
OCU49_RS14835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OCU49_RS14840	COG1522	sequence-specific DNA binding
OCU49_RS14855	COG0308	aminopeptidase N
OCU49_RS14875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OCU49_RS14880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OCU49_RS14885	COG2515	1-aminocyclopropane-1-carboxylate deaminase
OCU49_RS14960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OCU49_RS14965	COG0436	Aminotransferase
OCU49_RS14975	COG1639	'signal transduction protein
OCU49_RS14980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OCU49_RS14985	COG0501	Belongs to the peptidase M48B family
OCU49_RS15025	COG0513	Belongs to the DEAD box helicase family
OCU49_RS15035	COG2095	MarC family integral membrane protein
OCU49_RS15045	COG0791	NLP P60 protein
OCU49_RS15065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCU49_RS15080	COG3081	Nucleoid-associated protein
OCU49_RS15100	COG0717	Belongs to the dCTP deaminase family
OCU49_RS15105	COG0489	protein tyrosine kinase activity
OCU49_RS15130	COG1234	tRNA 3'-trailer cleavage
OCU49_RS15135	COG0450	alkyl hydroperoxide reductase
OCU49_RS15145	COG2824	Alkylphosphonate utilization operon protein PhnA
OCU49_RS15215	COG1492	cobalamin metabolic process
OCU49_RS15265	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
OCU49_RS15270	COG1797	cobyrinic acid a,c-diamide synthase activity
OCU49_RS15305	COG0310	cobalt ion transport
OCU49_RS15320	COG0602	queuosine metabolic process
OCU49_RS15325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OCU49_RS15330	COG3706	GGDEF domain
OCU49_RS15340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS15345	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
OCU49_RS15360	COG4067	protein conserved in archaea
OCU49_RS15360	COG0189	ligase activity
OCU49_RS15370	COG0330	HflC and HflK could
OCU49_RS15390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCU49_RS15395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCU49_RS15400	COG1538	Outer membrane efflux protein
OCU49_RS15405	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OCU49_RS15425	COG0583	DNA-binding transcription factor activity
OCU49_RS15435	COG4120	Belongs to the binding-protein-dependent transport system permease family
OCU49_RS15440	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
OCU49_RS15460	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS15470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OCU49_RS15485	COG2249	NAD(P)H dehydrogenase (quinone) activity
OCU49_RS15505	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS15520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OCU49_RS15525	COG1024	Enoyl-CoA hydratase
OCU49_RS15530	COG1960	acyl-CoA dehydrogenase activity
OCU49_RS15545	COG2203	Gaf domain
OCU49_RS15545	COG4251	negative regulation of phosphorylation
OCU49_RS15545	COG5001	Diguanylate cyclase
OCU49_RS15545	COG3706	GGDEF domain
OCU49_RS15550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OCU49_RS15555	COG0583	DNA-binding transcription factor activity
OCU49_RS15560	COG0183	Belongs to the thiolase family
OCU49_RS15565	COG4214	carbohydrate transport
OCU49_RS15570	COG0559	Belongs to the binding-protein-dependent transport system permease family
OCU49_RS15590	COG0789	Transcriptional regulator
OCU49_RS15595	COG1960	acyl-CoA dehydrogenase activity
OCU49_RS15600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OCU49_RS15605	COG1024	Enoyl-CoA hydratase
OCU49_RS15610	COG4770	biotin carboxylase activity
OCU49_RS15625	COG0318	PFAM AMP-dependent synthetase and ligase
OCU49_RS15630	COG2226	methyltransferase
OCU49_RS15640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCU49_RS15655	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS15670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS15675	COG0840	transmembrane signaling receptor activity
OCU49_RS15680	COG1177	transmembrane transport
OCU49_RS15685	COG1176	ABC-type spermidine putrescine transport system, permease component I
OCU49_RS15690	COG3842	ATPase activity
OCU49_RS15725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS15730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS15735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS15745	COG0730	response to heat
OCU49_RS15750	COG0659	secondary active sulfate transmembrane transporter activity
OCU49_RS15755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OCU49_RS15785	COG0484	heat shock protein binding
OCU49_RS15795	COG2204	response regulator
OCU49_RS15800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OCU49_RS15805	COG3530	Putative quorum-sensing-regulated virulence factor
OCU49_RS15810	COG3217	Mosc domain protein beta barrel domain protein
OCU49_RS15810	COG0633	Ferredoxin
OCU49_RS15815	COG1444	tRNA N-acetyltransferase activity
OCU49_RS15855	COG0625	glutathione transferase activity
OCU49_RS15870	COG5598	trimethylamine methyltransferase
OCU49_RS15880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS15890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCU49_RS15890	COG0446	pyridine nucleotide-disulphide oxidoreductase
OCU49_RS15900	COG1238	metal cluster binding
OCU49_RS15905	COG0514	ATP-dependent DNA helicase (RecQ)
OCU49_RS15950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OCU49_RS15960	COG2165	general secretion pathway protein
OCU49_RS16020	COG3133	Outer membrane lipoprotein
OCU49_RS16025	COG1132	(ABC) transporter
OCU49_RS16035	COG0271	Belongs to the BolA IbaG family
OCU49_RS16070	COG1944	ATP diphosphatase activity
OCU49_RS16105	COG1362	aminopeptidase activity
OCU49_RS16130	COG3214	Protein conserved in bacteria
OCU49_RS16140	COG0039	L-malate dehydrogenase activity
OCU49_RS16145	COG0583	DNA-binding transcription factor activity
OCU49_RS16150	COG0006	proline dipeptidase activity
OCU49_RS16155	COG1309	transcriptional regulator
OCU49_RS16175	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS16190	COG1741	Belongs to the pirin family
OCU49_RS16195	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS16205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
OCU49_RS16225	COG0348	domain, Protein
OCU49_RS16225	COG3901	Regulator of nitric oxide reductase transcription
OCU49_RS16230	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCU49_RS16250	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS16255	COG3302	dmso reductase anchor subunit
OCU49_RS16265	COG0243	molybdopterin cofactor binding
OCU49_RS16270	COG0730	response to heat
OCU49_RS16290	COG1846	Transcriptional regulator
OCU49_RS16290	COG1940	carbohydrate kinase activity
OCU49_RS16310	COG1414	Transcriptional regulator
OCU49_RS16315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
OCU49_RS16320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS16325	COG0076	glutamate decarboxylase activity
OCU49_RS16330	COG0583	DNA-binding transcription factor activity
OCU49_RS16335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OCU49_RS16350	COG0583	DNA-binding transcription factor activity
OCU49_RS16365	COG0788	formyltetrahydrofolate deformylase activity
OCU49_RS16385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS16395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS16395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS16410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
OCU49_RS16415	COG2853	Lipoprotein
OCU49_RS16425	COG1643	Atp-dependent helicase
OCU49_RS16430	COG0121	glutamine amidotransferase
OCU49_RS16440	COG0739	heme binding
OCU49_RS16450	COG1611	Belongs to the LOG family
OCU49_RS16455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OCU49_RS16475	COG0745	RESPONSE REGULATOR receiver
OCU49_RS16480	COG0668	transmembrane transport
OCU49_RS16485	COG1061	Type III restriction enzyme res subunit
OCU49_RS16525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OCU49_RS16540	COG3038	cytochrome b561
OCU49_RS16550	COG1278	Cold shock
OCU49_RS16555	COG3122	Protein conserved in bacteria
OCU49_RS16560	COG1278	Cold shock
OCU49_RS16570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OCU49_RS16570	COG4191	Histidine kinase
OCU49_RS16575	COG2204	response regulator
OCU49_RS16580	COG1027	Aspartate ammonia-lyase
OCU49_RS16590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
OCU49_RS16615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OCU49_RS16615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OCU49_RS16620	COG0509	glycine decarboxylation via glycine cleavage system
OCU49_RS16625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OCU49_RS16630	COG1760	l-serine dehydratase
OCU49_RS16640	COG1115	amino acid carrier protein
OCU49_RS16645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCU49_RS16650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OCU49_RS16655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OCU49_RS16665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS16675	COG3048	D-serine ammonia-lyase activity
OCU49_RS16695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCU49_RS16705	COG0243	molybdopterin cofactor binding
OCU49_RS16710	COG1187	pseudouridine synthase activity
OCU49_RS16725	COG1177	transmembrane transport
OCU49_RS16730	COG1176	ABC-type spermidine putrescine transport system, permease component I
OCU49_RS16735	COG3842	ATPase activity
OCU49_RS16755	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS16760	COG2431	L-lysine efflux transmembrane transporter activity
OCU49_RS16765	COG2197	response regulator
OCU49_RS16770	COG0513	Belongs to the DEAD box helicase family
OCU49_RS16775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OCU49_RS16780	COG0513	Belongs to the DEAD box helicase family
OCU49_RS16785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OCU49_RS16790	COG1522	sequence-specific DNA binding
OCU49_RS16825	COG4191	Histidine kinase
OCU49_RS16830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OCU49_RS16835	COG0077	Prephenate dehydratase
OCU49_RS16835	COG1605	Chorismate mutase
OCU49_RS16860	COG3647	Membrane
OCU49_RS16890	COG0395	ABC-type sugar transport system, permease component
OCU49_RS16900	COG3842	ATPase activity
OCU49_RS16905	COG3842	ATPase activity
OCU49_RS16910	COG3284	Transcriptional regulator
OCU49_RS16915	COG1968	undecaprenyl-diphosphatase activity
OCU49_RS16925	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
OCU49_RS16925	COG1918	ferrous iron import across plasma membrane
OCU49_RS16930	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
OCU49_RS16940	COG2205	protein histidine kinase activity
OCU49_RS16940	COG2770	Histidine kinase
OCU49_RS16945	COG0745	RESPONSE REGULATOR receiver
OCU49_RS16990	COG1162	GTPase activity
OCU49_RS17010	COG1228	amidohydrolase
OCU49_RS17015	COG0583	DNA-binding transcription factor activity
OCU49_RS17025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OCU49_RS17030	COG1349	DNA-binding transcription factor activity
OCU49_RS17040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OCU49_RS17045	COG0469	pyruvate kinase activity
OCU49_RS17050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OCU49_RS17055	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS17065	COG2738	Putative neutral zinc metallopeptidase
OCU49_RS17080	COG2814	Major facilitator Superfamily
OCU49_RS17085	COG1666	GTP binding
OCU49_RS17100	COG2096	Adenosyltransferase
OCU49_RS17115	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OCU49_RS17145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OCU49_RS17160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OCU49_RS17160	COG0646	methionine synthase
OCU49_RS17185	COG0840	transmembrane signaling receptor activity
OCU49_RS17210	COG0270	DNA (cytosine-5-)-methyltransferase activity
OCU49_RS17215	COG3727	T/G mismatch-specific endonuclease activity
OCU49_RS17230	COG0583	DNA-binding transcription factor activity
OCU49_RS17240	COG1574	metal-dependent hydrolase with the TIM-barrel fold
OCU49_RS17260	COG1278	Cold shock
OCU49_RS17270	COG4221	oxidoreductase activity
OCU49_RS17300	COG2249	NAD(P)H dehydrogenase (quinone) activity
OCU49_RS17315	COG0776	regulation of translation
OCU49_RS17320	COG0072	phenylalanine-tRNA ligase activity
OCU49_RS17325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OCU49_RS17330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OCU49_RS17335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OCU49_RS17345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OCU49_RS17350	COG1956	GAF domain-containing protein
OCU49_RS17365	COG0753	catalase activity
OCU49_RS17370	COG1846	Transcriptional regulator
OCU49_RS17385	COG2186	Transcriptional regulator
OCU49_RS17390	COG0247	lactate metabolic process
OCU49_RS17395	COG1139	Iron-sulfur cluster binding protein
OCU49_RS17440	COG0010	Belongs to the arginase family
OCU49_RS17450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OCU49_RS17475	COG0583	DNA-binding transcription factor activity
OCU49_RS17490	COG0513	Belongs to the DEAD box helicase family
OCU49_RS17495	COG4459	periplasmic nitrate reductase
OCU49_RS17500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OCU49_RS17500	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
OCU49_RS17510	COG0243	molybdopterin cofactor binding
OCU49_RS17515	COG0437	4 iron, 4 sulfur cluster binding
OCU49_RS17520	COG0348	domain, Protein
OCU49_RS17525	COG3043	anaerobic respiration
OCU49_RS17530	COG3005	denitrification pathway
OCU49_RS17535	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OCU49_RS17560	COG0583	DNA-binding transcription factor activity
OCU49_RS17565	COG4172	Belongs to the ABC transporter superfamily
OCU49_RS17570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OCU49_RS17580	COG0747	negative chemotaxis
OCU49_RS17595	COG2354	Protein conserved in bacteria
OCU49_RS17600	COG1802	Transcriptional regulator
OCU49_RS17620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCU49_RS17625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCU49_RS17640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OCU49_RS17650	COG3842	ATPase activity
OCU49_RS17655	COG1840	ABC-type Fe3 transport system, periplasmic component
OCU49_RS17695	COG0183	Belongs to the thiolase family
OCU49_RS17700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
OCU49_RS17705	COG3248	Nucleoside-binding outer membrane protein
OCU49_RS17715	COG1414	Transcriptional regulator
OCU49_RS17725	COG3485	protocatechuate 3,4-dioxygenase
OCU49_RS17730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS17765	COG2080	2 iron, 2 sulfur cluster binding
OCU49_RS17770	COG2010	Cytochrome c
OCU49_RS17770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OCU49_RS17780	COG0417	DNA replication proofreading
OCU49_RS17800	COG3425	synthase
OCU49_RS17825	COG0137	argininosuccinate synthase activity
OCU49_RS17835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OCU49_RS17840	COG2814	Major facilitator Superfamily
OCU49_RS17845	COG0450	alkyl hydroperoxide reductase
OCU49_RS17850	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
OCU49_RS17855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OCU49_RS17860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OCU49_RS17865	COG0583	DNA-binding transcription factor activity
OCU49_RS17875	COG2199	diguanylate cyclase activity
OCU49_RS17880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
OCU49_RS17915	COG2267	carboxylic ester hydrolase activity
OCU49_RS17925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OCU49_RS17930	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS17935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS17940	COG4948	Mandelate Racemase Muconate Lactonizing
OCU49_RS17950	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
OCU49_RS18030	COG0826	peptidase U32
OCU49_RS18050	COG0583	DNA-binding transcription factor activity
OCU49_RS18055	COG2866	Carboxypeptidase
OCU49_RS18060	COG4608	Belongs to the ABC transporter superfamily
OCU49_RS18065	COG0444	Belongs to the ABC transporter superfamily
OCU49_RS18070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OCU49_RS18075	COG0601	transmembrane transport
OCU49_RS18090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS18110	COG2358	TRAP transporter, solute receptor (TAXI family
OCU49_RS18130	COG0235	Class ii aldolase
OCU49_RS18145	COG5598	trimethylamine methyltransferase
OCU49_RS18175	COG5012	cobalamin binding
OCU49_RS18200	COG2315	Protein conserved in bacteria
OCU49_RS18210	COG0583	DNA-binding transcription factor activity
OCU49_RS18220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS18230	COG0454	-acetyltransferase
OCU49_RS18235	COG0456	acetyltransferase
OCU49_RS18275	COG0625	glutathione transferase activity
OCU49_RS18305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS18315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS18315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS18340	COG1331	Highly conserved protein containing a thioredoxin domain
OCU49_RS18345	COG1304	FMN binding
OCU49_RS18360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OCU49_RS18380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OCU49_RS18380	COG2010	Cytochrome c
OCU49_RS18385	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OCU49_RS18420	COG0189	ligase activity
OCU49_RS18420	COG4067	protein conserved in archaea
OCU49_RS18470	COG4964	Belongs to the GSP D family
OCU49_RS18500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
OCU49_RS18505	COG1846	Transcriptional regulator
OCU49_RS18515	COG1764	response to oxidative stress
OCU49_RS18520	COG1942	4-Oxalocrotonate Tautomerase
OCU49_RS18530	COG0625	glutathione transferase activity
OCU49_RS18535	COG0583	DNA-binding transcription factor activity
OCU49_RS18555	COG2900	Belongs to the SlyX family
OCU49_RS18560	COG0742	ribosomal rna small subunit methyltransferase
OCU49_RS18565	COG1968	undecaprenyl-diphosphatase activity
OCU49_RS18570	COG1214	PFAM Peptidase M22, glycoprotease
OCU49_RS18580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OCU49_RS18585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
OCU49_RS18605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OCU49_RS18650	COG2197	response regulator
OCU49_RS18655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCU49_RS18690	COG1322	Protein conserved in bacteria
OCU49_RS18720	COG3784	Protein of unknown function (DUF1318)
OCU49_RS18750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OCU49_RS18760	COG0778	Nitroreductase
OCU49_RS18770	COG0842	Transport permease protein
OCU49_RS18775	COG1131	(ABC) transporter
OCU49_RS18845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OCU49_RS18850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OCU49_RS18855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OCU49_RS18860	COG2003	Belongs to the UPF0758 family
OCU49_RS18870	COG0756	dUTP diphosphatase activity
OCU49_RS18875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OCU49_RS18880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OCU49_RS18885	COG1309	transcriptional regulator
OCU49_RS18895	COG2861	carbohydrate metabolic process
OCU49_RS18900	COG0793	Belongs to the peptidase S41A family
OCU49_RS18905	COG4942	peptidase
OCU49_RS18910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OCU49_RS18915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OCU49_RS18925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
OCU49_RS18940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OCU49_RS18945	COG2204	response regulator
OCU49_RS18950	COG3852	Histidine kinase
OCU49_RS18955	COG0174	glutamine synthetase
OCU49_RS18960	COG1217	gtp-binding protein TYPA
OCU49_RS18970	COG1757	Na H antiporter
OCU49_RS18985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCU49_RS19010	COG0251	oxidation-reduction process
OCU49_RS19015	COG0251	oxidation-reduction process
OCU49_RS19020	COG1832	CoA-binding protein
OCU49_RS19025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OCU49_RS19030	COG2890	protein-(glutamine-N5) methyltransferase activity
OCU49_RS19035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OCU49_RS19040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OCU49_RS19050	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
OCU49_RS19060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OCU49_RS19070	COG0193	aminoacyl-tRNA hydrolase activity
OCU49_RS19075	COG0012	GTP binding
OCU49_RS19110	COG3300	MHYT domain
OCU49_RS19110	COG5001	Diguanylate cyclase
OCU49_RS19120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCU49_RS19125	COG0653	protein targeting
OCU49_RS19165	COG1538	Outer membrane efflux protein
OCU49_RS19170	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS19175	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
OCU49_RS19185	COG4413	Urea transporter
OCU49_RS19195	COG3119	arylsulfatase activity
OCU49_RS19200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS19215	COG0557	exoribonuclease II activity
OCU49_RS19230	COG1862	Preprotein translocase
OCU49_RS19235	COG0343	queuine tRNA-ribosyltransferase activity
OCU49_RS19240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OCU49_RS19275	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS19305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OCU49_RS19310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OCU49_RS19320	COG0545	Peptidyl-prolyl cis-trans isomerase
OCU49_RS19335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OCU49_RS19350	COG1902	pentaerythritol trinitrate reductase activity
OCU49_RS19365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OCU49_RS19370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OCU49_RS19380	COG4774	siderophore transport
OCU49_RS19380	COG1629	transport
OCU49_RS19385	COG1629	transport
OCU49_RS19385	COG4774	siderophore transport
OCU49_RS19415	COG0583	DNA-binding transcription factor activity
OCU49_RS19425	COG1473	amidohydrolase
OCU49_RS19430	COG0523	cobalamin synthesis protein
OCU49_RS19460	COG0583	DNA-binding transcription factor activity
OCU49_RS19465	COG0583	DNA-binding transcription factor activity
OCU49_RS19480	COG0604	alcohol dehydrogenase
OCU49_RS19485	COG2186	Transcriptional regulator
OCU49_RS19495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS19540	COG0754	glutathionylspermidine amidase activity
OCU49_RS19545	COG2207	Transcriptional regulator
OCU49_RS19545	COG3708	Transcriptional regulator
OCU49_RS19555	COG4774	siderophore transport
OCU49_RS19565	COG1595	DNA-templated transcription, initiation
OCU49_RS19575	COG0840	transmembrane signaling receptor activity
OCU49_RS19590	COG1858	cytochrome C peroxidase
OCU49_RS19600	COG0697	spore germination
OCU49_RS19615	COG0259	pyridoxamine-phosphate oxidase activity
OCU49_RS19670	COG1116	anion transmembrane transporter activity
OCU49_RS19675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OCU49_RS19680	COG0583	DNA-binding transcription factor activity
OCU49_RS19695	COG0583	DNA-binding transcription factor activity
OCU49_RS19720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OCU49_RS19725	COG0789	Transcriptional regulator
OCU49_RS19735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS19785	COG0583	DNA-binding transcription factor activity
OCU49_RS19795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OCU49_RS19810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OCU49_RS19830	COG4638	Rieske (2fe-2S)
OCU49_RS19835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS19840	COG0583	DNA-binding transcription factor activity
OCU49_RS19855	COG0583	DNA-binding transcription factor activity
OCU49_RS19865	COG2233	PERMEase
OCU49_RS19880	COG1309	transcriptional regulator
OCU49_RS19890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OCU49_RS19900	COG0402	S-adenosylhomocysteine deaminase activity
OCU49_RS19915	COG2252	PERMEase
OCU49_RS19920	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS19940	COG4266	Belongs to the allantoicase family
OCU49_RS19975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS19985	COG4191	Histidine kinase
OCU49_RS19995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS20000	COG4251	negative regulation of phosphorylation
OCU49_RS20000	COG5001	Diguanylate cyclase
OCU49_RS20000	COG3706	GGDEF domain
OCU49_RS20000	COG2203	Gaf domain
OCU49_RS20005	COG0668	transmembrane transport
OCU49_RS20010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OCU49_RS20015	COG1119	ATPase activity
OCU49_RS20030	COG4774	siderophore transport
OCU49_RS20050	COG5001	Diguanylate cyclase
OCU49_RS20050	COG3706	GGDEF domain
OCU49_RS20050	COG4251	negative regulation of phosphorylation
OCU49_RS20050	COG2203	Gaf domain
OCU49_RS20055	COG0745	RESPONSE REGULATOR receiver
OCU49_RS20060	COG0625	glutathione transferase activity
OCU49_RS20070	COG0840	transmembrane signaling receptor activity
OCU49_RS20085	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS20090	COG2813	Specifically methylates the guanine in position
OCU49_RS20105	COG0784	Response regulator, receiver
OCU49_RS20105	COG2205	protein histidine kinase activity
OCU49_RS20105	COG5002	protein histidine kinase activity
OCU49_RS20120	COG2304	oxidoreductase activity
OCU49_RS20140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OCU49_RS20175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OCU49_RS20240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OCU49_RS20245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OCU49_RS20250	COG2226	methyltransferase
OCU49_RS20255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
OCU49_RS20260	COG2089	acid synthase
OCU49_RS20270	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OCU49_RS20275	COG0668	transmembrane transport
OCU49_RS20305	COG0406	alpha-ribazole phosphatase activity
OCU49_RS20325	COG0601	transmembrane transport
OCU49_RS20330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OCU49_RS20340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS20340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
OCU49_RS20355	COG3089	Belongs to the UPF0270 family
OCU49_RS20360	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OCU49_RS20365	COG3115	cell septum assembly
OCU49_RS20365	COG3115	cell septum assembly
OCU49_RS20385	COG1138	Cytochrome C-type biogenesis protein
OCU49_RS20390	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
OCU49_RS20410	COG4133	protoheme IX ABC transporter activity
OCU49_RS20420	COG2257	FlhB HrpN YscU SpaS Family
OCU49_RS20435	COG1192	Involved in chromosome partitioning
OCU49_RS20440	COG1360	Flagellar Motor Protein
OCU49_RS20445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OCU49_RS20455	COG0643	Histidine kinase
OCU49_RS20455	COG0784	Response regulator, receiver
OCU49_RS20455	COG2198	Histidine kinase
OCU49_RS20460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
OCU49_RS20495	COG1684	flagellar biosynthetic protein fliR
OCU49_RS20500	COG1987	bacterial-type flagellum assembly
OCU49_RS20530	COG3144	bacterial-type flagellum assembly
OCU49_RS20550	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OCU49_RS20560	COG1677	Flagellar hook-basal body complex protein FliE
OCU49_RS20575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OCU49_RS20585	COG2205	protein histidine kinase activity
OCU49_RS20585	COG0784	Response regulator, receiver
OCU49_RS20595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OCU49_RS20620	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OCU49_RS20655	COG1706	bacterial-type flagellum-dependent cell motility
OCU49_RS20660	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
OCU49_RS20670	COG4786	Flagellar basal body rod
OCU49_RS20675	COG1749	Flagellar hook protein flgE
OCU49_RS20690	COG1815	bacterial-type flagellum-dependent cell motility
OCU49_RS20695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OCU49_RS20700	COG0784	Response regulator, receiver
OCU49_RS20700	COG0835	chemotaxis
OCU49_RS20725	COG0745	RESPONSE REGULATOR receiver
OCU49_RS20730	COG0123	including yeast histone deacetylase and acetoin utilization protein
OCU49_RS20735	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
OCU49_RS20745	COG3630	sodium ion export across plasma membrane
OCU49_RS20750	COG0301	tRNA thio-modification
OCU49_RS20750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OCU49_RS20755	COG3706	GGDEF domain
OCU49_RS20760	COG2201	protein-glutamate methylesterase activity
OCU49_RS20770	COG2274	protein secretion by the type I secretion system
OCU49_RS20775	COG2274	protein secretion by the type I secretion system
OCU49_RS20805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OCU49_RS20810	COG0527	aspartate kinase activity
OCU49_RS20815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OCU49_RS20825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OCU49_RS20830	COG1546	Belongs to the CinA family
OCU49_RS20845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OCU49_RS20855	COG1187	pseudouridine synthase activity
OCU49_RS20900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OCU49_RS20930	COG0109	protoheme IX farnesyltransferase activity
OCU49_RS20935	COG1612	heme a metabolic process
OCU49_RS20955	COG1845	cytochrome c oxidase, subunit III
OCU49_RS20960	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
OCU49_RS20965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OCU49_RS20970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OCU49_RS20975	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
OCU49_RS20980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OCU49_RS20985	COG1183	phosphatidylcholine synthase activity
OCU49_RS21010	COG1496	oxidoreductase activity
OCU49_RS21035	COG1185	polyribonucleotide nucleotidyltransferase activity
OCU49_RS21040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OCU49_RS21050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OCU49_RS21055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OCU49_RS21060	COG0195	Participates in both transcription termination and antitermination
OCU49_RS21065	COG0779	Required for maturation of 30S ribosomal subunits
OCU49_RS21080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OCU49_RS21085	COG0149	triose-phosphate isomerase activity
OCU49_RS21090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OCU49_RS21095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OCU49_RS21100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OCU49_RS21105	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
OCU49_RS21120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OCU49_RS21135	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
OCU49_RS21170	COG2996	Protein conserved in bacteria
OCU49_RS21180	COG0709	Synthesizes selenophosphate from selenide and ATP
OCU49_RS21190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OCU49_RS21190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OCU49_RS21205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OCU49_RS21210	COG0583	DNA-binding transcription factor activity
OCU49_RS21260	COG3150	esterase
OCU49_RS21265	COG0583	DNA-binding transcription factor activity
OCU49_RS21280	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
OCU49_RS21295	COG0028	Belongs to the TPP enzyme family
OCU49_RS21305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
OCU49_RS21310	COG0281	malic enzyme
OCU49_RS21315	COG0254	rRNA binding
OCU49_RS21320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OCU49_RS21325	COG0018	arginyl-trna synthetase
OCU49_RS21330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
OCU49_RS21335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OCU49_RS21340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OCU49_RS21350	COG2226	methyltransferase
OCU49_RS21360	COG1981	membrane
OCU49_RS21365	COG0179	Fumarylacetoacetate (FAA) hydrolase
OCU49_RS21370	COG3123	guanosine phosphorylase activity
OCU49_RS21390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OCU49_RS21405	COG0667	Aldo Keto reductase
OCU49_RS21410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OCU49_RS21415	COG0509	glycine decarboxylation via glycine cleavage system
OCU49_RS21420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OCU49_RS21425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
OCU49_RS21430	COG0006	proline dipeptidase activity
OCU49_RS21435	COG3079	Belongs to the UPF0149 family
OCU49_RS21455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OCU49_RS21475	COG0840	transmembrane signaling receptor activity
OCU49_RS21480	COG0165	Argininosuccinate lyase
OCU49_RS21485	COG0181	hydroxymethylbilane synthase activity
OCU49_RS21490	COG1587	Uroporphyrinogen-III synthase
OCU49_RS21495	COG2959	enzyme of heme biosynthesis
OCU49_RS21510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
OCU49_RS21525	COG0248	Ppx GppA phosphatase
OCU49_RS21535	COG0203	ribosomal protein L17
OCU49_RS21550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OCU49_RS21555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OCU49_RS21560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OCU49_RS21570	COG0200	Binds to the 23S rRNA
OCU49_RS21575	COG1841	ribosomal large subunit assembly
OCU49_RS21580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OCU49_RS21585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OCU49_RS21590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OCU49_RS21595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OCU49_RS21600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OCU49_RS21605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OCU49_RS21610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OCU49_RS21615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OCU49_RS21620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OCU49_RS21625	COG0255	Belongs to the universal ribosomal protein uL29 family
OCU49_RS21630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OCU49_RS21635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OCU49_RS21640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OCU49_RS21645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OCU49_RS21650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OCU49_RS21655	COG0089	rRNA binding
OCU49_RS21660	COG0088	Forms part of the polypeptide exit tunnel
OCU49_RS21665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OCU49_RS21670	COG0051	transcription antitermination factor activity, RNA binding
OCU49_RS21675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OCU49_RS21680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OCU49_RS21685	COG0049	tRNA binding
OCU49_RS21690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OCU49_RS21695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OCU49_RS21700	COG0085	RNA polymerase activity
OCU49_RS21705	COG0222	ribosome binding
OCU49_RS21715	COG0081	regulation of translation
OCU49_RS21720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OCU49_RS21740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OCU49_RS21770	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OCU49_RS21785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OCU49_RS21790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OCU49_RS21795	COG0730	response to heat
OCU49_RS21810	COG0494	nUDIX hydrolase
OCU49_RS21820	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS21825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCU49_RS21830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OCU49_RS21850	COG0642	Histidine kinase
OCU49_RS21890	COG0210	DNA helicase
OCU49_RS21900	COG0606	chelatase, subunit chli
OCU49_RS21910	COG0004	ammonium transporteR
OCU49_RS21945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OCU49_RS21960	COG2205	protein histidine kinase activity
OCU49_RS21965	COG0745	RESPONSE REGULATOR receiver
OCU49_RS21975	COG1573	uracil-dna glycosylase
OCU49_RS21980	COG1858	cytochrome C peroxidase
OCU49_RS21985	COG3273	potassium ion transport
OCU49_RS21985	COG0471	metal ion transport
OCU49_RS21990	COG0583	DNA-binding transcription factor activity
OCU49_RS22000	COG0191	fructose-bisphosphate aldolase activity
OCU49_RS22005	COG0126	phosphoglycerate kinase activity
OCU49_RS22015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
OCU49_RS22020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OCU49_RS22025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OCU49_RS22030	COG0189	ligase activity
OCU49_RS22040	COG1678	Uncharacterized ACR, COG1678
OCU49_RS22045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OCU49_RS22055	COG0540	Belongs to the ATCase OTCase family
OCU49_RS22065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS22070	COG0626	cystathionine gamma-synthase activity
OCU49_RS22080	COG2084	Dehydrogenase
OCU49_RS22090	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OCU49_RS22115	COG2205	protein histidine kinase activity
OCU49_RS22115	COG2770	Histidine kinase
OCU49_RS22120	COG0745	RESPONSE REGULATOR receiver
OCU49_RS22130	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS22150	COG3135	benzoate transporter
OCU49_RS22155	COG1396	sequence-specific DNA binding
OCU49_RS22180	COG3806	Anti-sigma factor
OCU49_RS22185	COG1595	DNA-templated transcription, initiation
OCU49_RS22200	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OCU49_RS22210	COG4221	oxidoreductase activity
OCU49_RS22245	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
OCU49_RS22250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OCU49_RS22255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OCU49_RS22260	COG3720	iron ion transport
OCU49_RS22265	COG4771	TonB-dependent receptor
OCU49_RS22270	COG4256	Hemin uptake protein
OCU49_RS22285	COG0848	biopolymer transport protein
OCU49_RS22290	COG0811	peptide transport
OCU49_RS22295	COG0811	peptide transport
OCU49_RS22320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS22370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OCU49_RS22375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OCU49_RS22415	COG2204	response regulator
OCU49_RS22420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS22425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS22430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS22435	COG0840	transmembrane signaling receptor activity
OCU49_RS22445	COG4191	Histidine kinase
OCU49_RS22450	COG2183	response to ionizing radiation
OCU49_RS22520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS22525	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS22565	COG0583	DNA-binding transcription factor activity
OCU49_RS22570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OCU49_RS22590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS22595	COG0174	glutamine synthetase
OCU49_RS22600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OCU49_RS22605	COG3842	ATPase activity
OCU49_RS22610	COG1176	ABC-type spermidine putrescine transport system, permease component I
OCU49_RS22615	COG1177	transmembrane transport
OCU49_RS22620	COG0519	Catalyzes the synthesis of GMP from XMP
OCU49_RS22620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OCU49_RS22625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS22630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
OCU49_RS22645	COG0583	DNA-binding transcription factor activity
OCU49_RS22650	COG1012	belongs to the aldehyde dehydrogenase family
OCU49_RS22660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS22690	COG0251	oxidation-reduction process
OCU49_RS22700	COG0583	DNA-binding transcription factor activity
OCU49_RS22725	COG0545	Peptidyl-prolyl cis-trans isomerase
OCU49_RS22735	COG0488	(ABC) transporter
OCU49_RS22740	COG1280	lysine exporter protein (LysE YggA)
OCU49_RS22750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OCU49_RS22755	COG1758	RNA polymerase activity
OCU49_RS22780	COG3220	belongs to the UPF0276 family
OCU49_RS22825	COG5002	protein histidine kinase activity
OCU49_RS22840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
OCU49_RS22880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OCU49_RS22885	COG0590	tRNA wobble adenosine to inosine editing
OCU49_RS22915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OCU49_RS22920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OCU49_RS22925	COG0537	adenosine 5'-monophosphoramidase activity
OCU49_RS22930	COG0140	phosphoribosyl-ATP diphosphatase activity
OCU49_RS22935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OCU49_RS22940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OCU49_RS22960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OCU49_RS22975	COG1733	regulation of RNA biosynthetic process
OCU49_RS22980	COG1028	Short-chain dehydrogenase reductase Sdr
OCU49_RS22995	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
OCU49_RS23000	COG1278	Cold shock
OCU49_RS23005	COG0557	exoribonuclease II activity
OCU49_RS23010	COG3300	MHYT domain
OCU49_RS23010	COG5001	Diguanylate cyclase
OCU49_RS23020	COG0840	transmembrane signaling receptor activity
OCU49_RS23025	COG0210	DNA helicase
OCU49_RS23050	COG0573	inorganic phosphate transmembrane transporter activity
OCU49_RS23055	COG0573	inorganic phosphate transmembrane transporter activity
OCU49_RS23060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OCU49_RS23075	COG2203	Gaf domain
OCU49_RS23075	COG3706	GGDEF domain
OCU49_RS23075	COG5001	Diguanylate cyclase
OCU49_RS23075	COG4251	negative regulation of phosphorylation
OCU49_RS23090	COG3161	chorismate lyase activity
OCU49_RS23095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
OCU49_RS23110	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
OCU49_RS23115	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
OCU49_RS23125	COG0604	alcohol dehydrogenase
OCU49_RS23170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
OCU49_RS23175	COG1737	Transcriptional regulator
OCU49_RS23190	COG0069	glutamate synthase activity
OCU49_RS23200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
OCU49_RS23205	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
OCU49_RS23210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
OCU49_RS23215	COG1473	amidohydrolase
OCU49_RS23225	COG1522	sequence-specific DNA binding
OCU49_RS23235	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
OCU49_RS23275	COG2095	MarC family integral membrane protein
OCU49_RS23280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OCU49_RS23285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OCU49_RS23335	COG0583	DNA-binding transcription factor activity
OCU49_RS23340	COG1126	abc transporter atp-binding protein
OCU49_RS23345	COG0765	amino acid transport
OCU49_RS23350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OCU49_RS23385	COG4977	sequence-specific DNA binding
OCU49_RS23395	COG1902	pentaerythritol trinitrate reductase activity
OCU49_RS23395	COG0446	pyridine nucleotide-disulphide oxidoreductase
OCU49_RS23405	COG0583	DNA-binding transcription factor activity
OCU49_RS23435	COG0583	DNA-binding transcription factor activity
OCU49_RS23440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OCU49_RS23450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OCU49_RS23450	COG0446	pyridine nucleotide-disulphide oxidoreductase
OCU49_RS23475	COG0513	Belongs to the DEAD box helicase family
OCU49_RS23485	COG0318	PFAM AMP-dependent synthetase and ligase
OCU49_RS23490	COG0789	Transcriptional regulator
OCU49_RS23495	COG0183	Belongs to the thiolase family
OCU49_RS23500	COG1250	3-hydroxyacyl-CoA dehydrogenase
OCU49_RS23500	COG1024	Enoyl-CoA hydratase
OCU49_RS23505	COG1960	acyl-CoA dehydrogenase activity
OCU49_RS23510	COG4628	conserved protein (DUF2132)
OCU49_RS23515	COG2226	methyltransferase
OCU49_RS23530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OCU49_RS23535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OCU49_RS23540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OCU49_RS23545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OCU49_RS23550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OCU49_RS23560	COG0356	it plays a direct role in the translocation of protons across the membrane
OCU49_RS23570	COG1475	DNA binding
OCU49_RS23575	COG1192	Involved in chromosome partitioning
OCU49_RS23580	COG0357	Ribosomal RNA small subunit methyltransferase G
OCU49_RS23585	COG0445	tRNA wobble uridine modification
OCU49_RS23590	COG0840	transmembrane signaling receptor activity
OCU49_RS23640	COG3118	belongs to the thioredoxin family
OCU49_RS23665	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OCU49_RS23670	COG0706	membrane insertase activity
OCU49_RS23675	COG0594	ribonuclease P activity
OCU49_RS23680	COG0230	Belongs to the bacterial ribosomal protein bL34 family