locus-tag	class	description
KOI47_RS00010	COG0592	DNA-directed DNA polymerase activity
KOI47_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KOI47_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KOI47_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
KOI47_RS00030	COG0187	DNA topoisomerase II activity
KOI47_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KOI47_RS00050	COG5592	hemerythrin HHE cation binding domain
KOI47_RS00090	COG1090	epimerase
KOI47_RS00100	COG1309	transcriptional regulator
KOI47_RS00150	COG0457	Tetratricopeptide repeat
KOI47_RS00150	COG0705	Rhomboid family
KOI47_RS00165	COG3764	Sortase (surface protein transpeptidase)
KOI47_RS00195	COG3409	Peptidoglycan-binding domain 1 protein
KOI47_RS00260	COG2815	serine threonine protein kinase
KOI47_RS00260	COG0515	serine threonine protein kinase
KOI47_RS00265	COG0515	serine threonine protein kinase
KOI47_RS00270	COG0768	penicillin binding
KOI47_RS00285	COG1716	ATPase activity
KOI47_RS00290	COG1716	ATPase activity
KOI47_RS00305	COG1309	transcriptional regulator
KOI47_RS00310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS00315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS00370	COG0626	cystathionine gamma-synthase activity
KOI47_RS00405	COG2186	Transcriptional regulator
KOI47_RS00410	COG0747	negative chemotaxis
KOI47_RS00420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOI47_RS00430	COG4608	Belongs to the ABC transporter superfamily
KOI47_RS00435	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS00445	COG0154	amidase activity
KOI47_RS00455	COG2301	Belongs to the HpcH HpaI aldolase family
KOI47_RS00465	COG0702	epimerase
KOI47_RS00490	COG2211	Major facilitator Superfamily
KOI47_RS00515	COG1174	glycine betaine transport
KOI47_RS00525	COG1174	glycine betaine transport
KOI47_RS00535	COG2175	clavaminate synthase activity
KOI47_RS00555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KOI47_RS00560	COG0405	Gamma-glutamyltransferase
KOI47_RS00635	COG0300	oxidoreductase activity
KOI47_RS00640	COG1742	UPF0060 membrane protein
KOI47_RS00655	COG3383	formate dehydrogenase (NAD+) activity
KOI47_RS00660	COG4585	Histidine kinase
KOI47_RS00670	COG2197	response regulator
KOI47_RS00675	COG0477	Major facilitator Superfamily
KOI47_RS00695	COG0438	transferase activity, transferring glycosyl groups
KOI47_RS00715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KOI47_RS00745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KOI47_RS00755	COG3275	phosphorelay sensor kinase activity
KOI47_RS00775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KOI47_RS00785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KOI47_RS00825	COG1528	Iron-storage protein
KOI47_RS00830	COG2235	arginine
KOI47_RS00885	COG4608	Belongs to the ABC transporter superfamily
KOI47_RS00890	COG0444	Belongs to the ABC transporter superfamily
KOI47_RS00895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOI47_RS00900	COG0601	transmembrane transport
KOI47_RS00905	COG4166	transmembrane transport
KOI47_RS00910	COG1271	oxidase subunit
KOI47_RS00915	COG1294	oxidase, subunit
KOI47_RS00970	COG0740	serine-type endopeptidase activity
KOI47_RS01050	COG4715	Zinc finger, swim domain protein
KOI47_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KOI47_RS01095	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KOI47_RS01110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KOI47_RS01165	COG0754	glutathionylspermidine amidase activity
KOI47_RS01170	COG3766	membrane
KOI47_RS01175	COG0596	Alpha beta hydrolase
KOI47_RS01180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KOI47_RS01190	COG0579	oxidoreductase
KOI47_RS01200	COG1309	transcriptional regulator
KOI47_RS01210	COG0477	Major facilitator Superfamily
KOI47_RS01265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KOI47_RS01270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KOI47_RS01290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KOI47_RS01300	COG0546	phosphoglycolate phosphatase activity
KOI47_RS01310	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS01315	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS01345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KOI47_RS01360	COG0561	phosphatase activity
KOI47_RS01380	COG0671	phosphoesterase, PA-phosphatase related
KOI47_RS01385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KOI47_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS01405	COG0277	FAD linked oxidase domain protein
KOI47_RS01415	COG1216	Glycosyl transferase, family 2
KOI47_RS01430	COG1216	Glycosyl transferase, family 2
KOI47_RS01460	COG2089	acid synthase
KOI47_RS01465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KOI47_RS01470	COG1086	Polysaccharide biosynthesis protein
KOI47_RS01475	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KOI47_RS01480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KOI47_RS01500	COG2234	aminopeptidase activity
KOI47_RS01540	COG2856	Zn peptidase
KOI47_RS01615	COG0653	protein targeting
KOI47_RS01690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KOI47_RS01745	COG2217	Heavy metal translocating P-type atpase
KOI47_RS01755	COG1672	PFAM Archaeal ATPase
KOI47_RS01755	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KOI47_RS01840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KOI47_RS01845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KOI47_RS01850	COG0412	Dienelactone hydrolase
KOI47_RS01870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KOI47_RS01915	COG3903	Transcriptional regulator
KOI47_RS01915	COG3629	intracellular signal transduction
KOI47_RS01920	COG0656	L-ascorbic acid biosynthetic process
KOI47_RS01930	COG3903	Transcriptional regulator
KOI47_RS01930	COG3629	intracellular signal transduction
KOI47_RS01950	COG1846	Transcriptional regulator
KOI47_RS01965	COG0183	Belongs to the thiolase family
KOI47_RS01995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS02015	COG3559	Exporter of polyketide antibiotics
KOI47_RS02020	COG1131	(ABC) transporter
KOI47_RS02045	COG0287	Prephenate dehydrogenase
KOI47_RS02050	COG1473	amidohydrolase
KOI47_RS02060	COG0590	tRNA wobble adenosine to inosine editing
KOI47_RS02065	COG3237	CsbD-like
KOI47_RS02080	COG2076	Multidrug Resistance protein
KOI47_RS02105	COG0443	Heat shock 70 kDa protein
KOI47_RS02135	COG1674	ftsk spoiiie
KOI47_RS02155	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KOI47_RS02180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KOI47_RS02195	COG4221	oxidoreductase activity
KOI47_RS02215	COG4152	abc transporter atp-binding protein
KOI47_RS02220	COG1668	transmembrane transport
KOI47_RS02225	COG0739	heme binding
KOI47_RS02270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KOI47_RS02340	COG0860	N-Acetylmuramoyl-L-alanine amidase
KOI47_RS02345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KOI47_RS02350	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KOI47_RS02355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KOI47_RS02360	COG1215	transferase activity, transferring glycosyl groups
KOI47_RS02375	COG1216	Glycosyl transferase, family 2
KOI47_RS02390	COG0747	negative chemotaxis
KOI47_RS02395	COG0601	transmembrane transport
KOI47_RS02400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOI47_RS02405	COG0444	Belongs to the ABC transporter superfamily
KOI47_RS02410	COG4608	Belongs to the ABC transporter superfamily
KOI47_RS02425	COG0697	spore germination
KOI47_RS02500	COG1690	Belongs to the RtcB family
KOI47_RS02560	COG0657	acetylesterase activity
KOI47_RS02565	COG0431	NADPH-dependent FMN reductase
KOI47_RS02580	COG4106	trans-aconitate 2-methyltransferase activity
KOI47_RS02610	COG1408	metallophosphoesterase
KOI47_RS02615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KOI47_RS02715	COG0596	Alpha beta hydrolase
KOI47_RS02730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KOI47_RS02735	COG3104	oligopeptide transport
KOI47_RS02750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KOI47_RS02760	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KOI47_RS02790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KOI47_RS02790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KOI47_RS02790	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KOI47_RS02790	COG3321	synthase
KOI47_RS02795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS02820	COG3433	isochorismatase activity
KOI47_RS02820	COG1535	isochorismatase
KOI47_RS02840	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KOI47_RS02845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KOI47_RS02850	COG1737	Transcriptional regulator
KOI47_RS02855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KOI47_RS02860	COG3876	Protein conserved in bacteria
KOI47_RS02865	COG1472	Belongs to the glycosyl hydrolase 3 family
KOI47_RS02880	COG2197	response regulator
KOI47_RS02890	COG1131	(ABC) transporter
KOI47_RS02945	COG1111	helicase
KOI47_RS02945	COG1205	dead DEAH box helicase
KOI47_RS02950	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KOI47_RS02980	COG1754	DNA topoisomerase type I activity
KOI47_RS02980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KOI47_RS02995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KOI47_RS03000	COG0470	DNA polymerase III
KOI47_RS03045	COG1674	ftsk spoiiie
KOI47_RS03080	COG0494	nUDIX hydrolase
KOI47_RS03090	COG0105	UTP biosynthetic process
KOI47_RS03115	COG4941	Belongs to the sigma-70 factor family
KOI47_RS03120	COG3795	YCII-related domain
KOI47_RS03135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KOI47_RS03145	COG1733	regulation of RNA biosynthetic process
KOI47_RS03150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KOI47_RS03155	COG2027	D-alanyl-D-alanine carboxypeptidase
KOI47_RS03165	COG0037	tRNA processing
KOI47_RS03195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KOI47_RS03205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KOI47_RS03220	COG0789	Transcriptional regulator
KOI47_RS03245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KOI47_RS03250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KOI47_RS03255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KOI47_RS03260	COG2076	Multidrug Resistance protein
KOI47_RS03270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KOI47_RS03325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KOI47_RS03350	COG1194	a g-specific adenine glycosylase
KOI47_RS03360	COG1609	Transcriptional regulator
KOI47_RS03370	COG1120	ATPase activity
KOI47_RS03390	COG4399	Belongs to the UPF0754 family
KOI47_RS03425	COG1070	Carbohydrate kinase
KOI47_RS03430	COG2814	Major facilitator Superfamily
KOI47_RS03435	COG1349	DNA-binding transcription factor activity
KOI47_RS03440	COG0588	phosphoglycerate mutase activity
KOI47_RS03445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KOI47_RS03450	COG2376	Dihydroxyacetone kinase
KOI47_RS03455	COG0698	ribose 5-phosphate isomerase
KOI47_RS03460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KOI47_RS03470	COG0235	Class ii aldolase
KOI47_RS03475	COG2207	Transcriptional regulator
KOI47_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS03485	COG1063	alcohol dehydrogenase
KOI47_RS03490	COG0477	Major facilitator Superfamily
KOI47_RS03525	COG1674	ftsk spoiiie
KOI47_RS03540	COG2188	Transcriptional regulator
KOI47_RS03565	COG0215	cysteine-tRNA ligase activity
KOI47_RS03575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KOI47_RS03580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KOI47_RS03585	COG1329	Transcriptional regulator
KOI47_RS03590	COG2847	Copper chaperone PCu(A)C
KOI47_RS03595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KOI47_RS03635	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KOI47_RS03665	COG2186	Transcriptional regulator
KOI47_RS03675	COG1115	amino acid carrier protein
KOI47_RS03805	COG0019	diaminopimelate decarboxylase activity
KOI47_RS03815	COG4264	IucA IucC family
KOI47_RS03825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KOI47_RS03840	COG1309	transcriptional regulator
KOI47_RS03855	COG1250	3-hydroxyacyl-CoA dehydrogenase
KOI47_RS03860	COG2124	cytochrome p450
KOI47_RS03865	COG0385	Bile acid
KOI47_RS03870	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS03870	COG2030	dehydratase
KOI47_RS03875	COG3396	Phenylacetate-CoA oxygenase
KOI47_RS03880	COG3460	Phenylacetate-CoA oxygenase
KOI47_RS03885	COG3396	Phenylacetate-CoA oxygenase
KOI47_RS03890	COG2151	metal-sulfur cluster biosynthetic enzyme
KOI47_RS03895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KOI47_RS03910	COG0346	lactoylglutathione lyase activity
KOI47_RS03915	COG0400	carboxylic ester hydrolase activity
KOI47_RS03920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KOI47_RS03930	COG0789	Transcriptional regulator
KOI47_RS03935	COG0667	Aldo Keto reductase
KOI47_RS03940	COG0667	Aldo Keto reductase
KOI47_RS03950	COG0477	Major facilitator Superfamily
KOI47_RS03975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KOI47_RS03990	COG0515	serine threonine protein kinase
KOI47_RS04015	COG1473	amidohydrolase
KOI47_RS04015	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KOI47_RS04035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KOI47_RS04040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KOI47_RS04045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KOI47_RS04085	COG4770	biotin carboxylase activity
KOI47_RS04100	COG2124	cytochrome p450
KOI47_RS04125	COG1301	dicarboxylic acid transport
KOI47_RS04130	COG0424	maF-like protein
KOI47_RS04155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KOI47_RS04215	COG0483	inositol monophosphate 1-phosphatase activity
KOI47_RS04220	COG0745	RESPONSE REGULATOR receiver
KOI47_RS04225	COG2205	protein histidine kinase activity
KOI47_RS04285	COG2259	Doxx family
KOI47_RS04295	COG1316	TRANSCRIPTIONal
KOI47_RS04300	COG1316	TRANSCRIPTIONal
KOI47_RS04335	COG0297	glycogen (starch) synthase activity
KOI47_RS04340	COG0438	transferase activity, transferring glycosyl groups
KOI47_RS04375	COG1725	Transcriptional regulator
KOI47_RS04385	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
KOI47_RS04385	COG0778	Nitroreductase
KOI47_RS04395	COG0456	acetyltransferase
KOI47_RS04395	COG1214	PFAM Peptidase M22, glycoprotease
KOI47_RS04405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KOI47_RS04440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KOI47_RS04445	COG1611	Belongs to the LOG family
KOI47_RS04455	COG0204	Acyl-transferase
KOI47_RS04460	COG0463	Glycosyl transferase, family 2
KOI47_RS04475	COG2818	Glycosylase
KOI47_RS04480	COG1024	Enoyl-CoA hydratase
KOI47_RS04495	COG2814	Major facilitator Superfamily
KOI47_RS04510	COG5662	AntiSigma factor
KOI47_RS04515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KOI47_RS04520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KOI47_RS04610	COG3903	Transcriptional regulator
KOI47_RS04610	COG3629	intracellular signal transduction
KOI47_RS04635	COG0598	Magnesium transport protein CorA
KOI47_RS04650	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS04660	COG2124	cytochrome p450
KOI47_RS04680	COG0613	PHP domain protein
KOI47_RS04685	COG2095	MarC family integral membrane protein
KOI47_RS04710	COG0513	Belongs to the DEAD box helicase family
KOI47_RS04725	COG2311	Membrane
KOI47_RS04750	COG1309	transcriptional regulator
KOI47_RS04770	COG3344	reverse transcriptase
KOI47_RS04780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KOI47_RS04790	COG0243	molybdopterin cofactor binding
KOI47_RS04795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KOI47_RS04800	COG2223	nitrite transmembrane transporter activity
KOI47_RS04805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KOI47_RS04805	COG2146	nitrite reductase [NAD(P)H] activity
KOI47_RS04810	COG2146	nitrite reductase [NAD(P)H] activity
KOI47_RS04845	COG1131	(ABC) transporter
KOI47_RS04855	COG0500	methyltransferase
KOI47_RS04870	COG2378	regulation of single-species biofilm formation
KOI47_RS04905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KOI47_RS04935	COG0714	Associated with various cellular activities
KOI47_RS05010	COG0612	Peptidase, M16
KOI47_RS05030	COG3265	gluconokinase activity
KOI47_RS05040	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KOI47_RS05060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KOI47_RS05175	COG0577	efflux transmembrane transporter activity
KOI47_RS05175	COG1136	(ABC) transporter
KOI47_RS05180	COG0577	efflux transmembrane transporter activity
KOI47_RS05180	COG1136	(ABC) transporter
KOI47_RS05195	COG0745	RESPONSE REGULATOR receiver
KOI47_RS05200	COG2205	protein histidine kinase activity
KOI47_RS05210	COG0557	exoribonuclease II activity
KOI47_RS05225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KOI47_RS05235	COG2318	DinB family
KOI47_RS05250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KOI47_RS05250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KOI47_RS05255	COG0653	protein targeting
KOI47_RS05290	COG0174	glutamine synthetase
KOI47_RS05310	COG1522	sequence-specific DNA binding
KOI47_RS05325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KOI47_RS05400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KOI47_RS05420	COG3480	Lon protease (S16) C-terminal proteolytic domain
KOI47_RS05440	COG1615	UPF0182 protein
KOI47_RS05460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KOI47_RS05465	COG2884	Cell division ATP-binding protein ftsE
KOI47_RS05470	COG2177	Part of the ABC transporter FtsEX involved in
KOI47_RS05475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KOI47_RS05495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KOI47_RS05505	COG2197	response regulator
KOI47_RS05510	COG4585	Histidine kinase
KOI47_RS05530	COG0667	Aldo Keto reductase
KOI47_RS05550	COG0702	epimerase
KOI47_RS05560	COG2814	Major facilitator Superfamily
KOI47_RS05570	COG0431	NADPH-dependent FMN reductase
KOI47_RS05575	COG0477	Major facilitator Superfamily
KOI47_RS05580	COG2814	Major facilitator Superfamily
KOI47_RS05585	COG0640	Transcriptional regulator
KOI47_RS05600	COG0697	spore germination
KOI47_RS05630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KOI47_RS05650	COG0583	DNA-binding transcription factor activity
KOI47_RS05655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KOI47_RS05680	COG0189	ligase activity
KOI47_RS05685	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KOI47_RS05690	COG3959	Transketolase, thiamine diphosphate binding domain
KOI47_RS05695	COG3958	Transketolase
KOI47_RS05700	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS05720	COG0402	S-adenosylhomocysteine deaminase activity
KOI47_RS05725	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS05760	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS05775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KOI47_RS05815	COG4585	Histidine kinase
KOI47_RS05820	COG2197	response regulator
KOI47_RS05830	COG2197	response regulator
KOI47_RS05835	COG0477	Major facilitator Superfamily
KOI47_RS05850	COG0300	oxidoreductase activity
KOI47_RS05855	COG2130	NADP-dependent
KOI47_RS05905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KOI47_RS05910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOI47_RS05915	COG0646	methionine synthase
KOI47_RS05915	COG1410	methionine synthase
KOI47_RS05920	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KOI47_RS05935	COG3647	Membrane
KOI47_RS05980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KOI47_RS06005	COG2986	histidine ammonia-lyase
KOI47_RS06010	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KOI47_RS06015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KOI47_RS06025	COG1228	amidohydrolase
KOI47_RS06045	COG4585	Histidine kinase
KOI47_RS06050	COG2197	response regulator
KOI47_RS06060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOI47_RS06095	COG0785	Cytochrome C biogenesis protein
KOI47_RS06110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KOI47_RS06115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KOI47_RS06135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KOI47_RS06180	COG3547	Transposase (IS116 IS110 IS902 family)
KOI47_RS06185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KOI47_RS06185	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KOI47_RS06235	COG0745	RESPONSE REGULATOR receiver
KOI47_RS06240	COG2205	protein histidine kinase activity
KOI47_RS06245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KOI47_RS06250	COG0456	acetyltransferase
KOI47_RS06255	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KOI47_RS06260	COG1181	Belongs to the D-alanine--D-alanine ligase family
KOI47_RS06275	COG0395	ABC-type sugar transport system, permease component
KOI47_RS06300	COG1595	DNA-templated transcription, initiation
KOI47_RS06340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOI47_RS06345	COG1132	(ABC) transporter
KOI47_RS06350	COG1132	(ABC) transporter
KOI47_RS06380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS06440	COG0517	IMP dehydrogenase activity
KOI47_RS06440	COG0617	tRNA 3'-terminal CCA addition
KOI47_RS06440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KOI47_RS06510	COG3386	PFAM SMP-30 Gluconolaconase
KOI47_RS06565	COG1175	transmembrane transport
KOI47_RS06570	COG1653	transport
KOI47_RS06575	COG1609	Transcriptional regulator
KOI47_RS06595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KOI47_RS06635	COG1218	3'(2'),5'-bisphosphate nucleotidase
KOI47_RS06640	COG0175	sulfate reduction
KOI47_RS06645	COG0529	Catalyzes the synthesis of activated sulfate
KOI47_RS06645	COG2895	sulfate adenylyltransferase (ATP) activity
KOI47_RS06660	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS06685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KOI47_RS06690	COG0154	amidase activity
KOI47_RS06740	COG2096	Adenosyltransferase
KOI47_RS06750	COG2936	dipeptidyl-peptidase activity
KOI47_RS06760	COG0739	heme binding
KOI47_RS06820	COG2205	protein histidine kinase activity
KOI47_RS06825	COG0745	RESPONSE REGULATOR receiver
KOI47_RS06830	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS06850	COG2239	Acts as a magnesium transporter
KOI47_RS06880	COG3938	Belongs to the proline racemase family
KOI47_RS06915	COG4552	Acetyltransferase involved in intracellular survival and related
KOI47_RS06940	COG1132	(ABC) transporter
KOI47_RS06950	COG1132	(ABC) transporter
KOI47_RS06965	COG2258	MOSC domain
KOI47_RS06985	COG0515	serine threonine protein kinase
KOI47_RS06995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS07010	COG4585	Histidine kinase
KOI47_RS07050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KOI47_RS07055	COG0084	hydrolase, TatD family'
KOI47_RS07060	COG3583	domain protein
KOI47_RS07065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KOI47_RS07070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KOI47_RS07100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KOI47_RS07105	COG0488	(ABC) transporter
KOI47_RS07110	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS07115	COG3599	regulation of cell shape
KOI47_RS07125	COG0193	aminoacyl-tRNA hydrolase activity
KOI47_RS07135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS07145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KOI47_RS07180	COG1846	Transcriptional regulator
KOI47_RS07190	COG2133	pyrroloquinoline quinone binding
KOI47_RS07205	COG3956	TIGRFAM MazG family protein
KOI47_RS07230	COG0148	phosphopyruvate hydratase activity
KOI47_RS07290	COG1252	NADH dehydrogenase
KOI47_RS07325	COG0667	Aldo Keto reductase
KOI47_RS07330	COG0137	argininosuccinate synthase activity
KOI47_RS07365	COG2366	antibiotic biosynthetic process
KOI47_RS07420	COG2072	flavoprotein involved in K transport
KOI47_RS07440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KOI47_RS07445	COG1414	Transcriptional regulator
KOI47_RS07455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KOI47_RS07460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KOI47_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS07490	COG5522	Integral membrane protein (intg_mem_TP0381)
KOI47_RS07505	COG0745	RESPONSE REGULATOR receiver
KOI47_RS07510	COG2205	protein histidine kinase activity
KOI47_RS07515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KOI47_RS07525	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KOI47_RS07530	COG4991	sh3 domain protein
KOI47_RS07540	COG0739	heme binding
KOI47_RS07565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KOI47_RS07570	COG2267	carboxylic ester hydrolase activity
KOI47_RS07580	COG3469	chitinase activity
KOI47_RS07630	COG4941	Belongs to the sigma-70 factor family
KOI47_RS07685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KOI47_RS07700	COG4988	ABC transporter
KOI47_RS07705	COG1294	oxidase, subunit
KOI47_RS07710	COG1271	oxidase subunit
KOI47_RS07715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KOI47_RS07715	COG0617	tRNA 3'-terminal CCA addition
KOI47_RS07715	COG0517	IMP dehydrogenase activity
KOI47_RS07730	COG2210	Belongs to the sulfur carrier protein TusA family
KOI47_RS07735	COG2920	part of a sulfur-relay system
KOI47_RS07740	COG1252	NADH dehydrogenase
KOI47_RS07760	COG1140	nitrate reductase beta subunit
KOI47_RS07790	COG2226	methyltransferase
KOI47_RS07830	COG2124	cytochrome p450
KOI47_RS07845	COG1937	Protein conserved in bacteria
KOI47_RS07850	COG2197	response regulator
KOI47_RS07855	COG4585	Histidine kinase
KOI47_RS07865	COG0187	DNA topoisomerase II activity
KOI47_RS07870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KOI47_RS07875	COG0477	Major facilitator Superfamily
KOI47_RS07885	COG0667	Aldo Keto reductase
KOI47_RS07900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS07900	COG3321	synthase
KOI47_RS07980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KOI47_RS08005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KOI47_RS08070	COG0596	Alpha beta hydrolase
KOI47_RS08085	COG2124	cytochrome p450
KOI47_RS08100	COG1716	ATPase activity
KOI47_RS08100	COG5001	Diguanylate cyclase
KOI47_RS08150	COG3384	dioxygenase
KOI47_RS08155	COG2267	carboxylic ester hydrolase activity
KOI47_RS08160	COG1414	Transcriptional regulator
KOI47_RS08165	COG0604	alcohol dehydrogenase
KOI47_RS08170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KOI47_RS08175	COG0583	DNA-binding transcription factor activity
KOI47_RS08180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KOI47_RS08215	COG0601	transmembrane transport
KOI47_RS08220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOI47_RS08250	COG2843	Capsule synthesis protein
KOI47_RS08265	COG3540	Alkaline phosphatase
KOI47_RS08295	COG3629	intracellular signal transduction
KOI47_RS08295	COG3903	Transcriptional regulator
KOI47_RS08305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOI47_RS08320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KOI47_RS08325	COG2183	response to ionizing radiation
KOI47_RS08350	COG0640	Transcriptional regulator
KOI47_RS08370	COG1090	epimerase
KOI47_RS08390	COG0129	dihydroxy-acid dehydratase activity
KOI47_RS08395	COG3971	2-oxopent-4-enoate hydratase activity
KOI47_RS08415	COG2197	response regulator
KOI47_RS08485	COG0778	Nitroreductase
KOI47_RS08515	COG1797	cobyrinic acid a,c-diamide synthase activity
KOI47_RS08535	COG0018	arginyl-trna synthetase
KOI47_RS08540	COG0019	diaminopimelate decarboxylase activity
KOI47_RS08545	COG0460	homoserine dehydrogenase
KOI47_RS08550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KOI47_RS08555	COG0083	homoserine kinase activity
KOI47_RS08560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KOI47_RS08575	COG0022	dehydrogenase e1 component
KOI47_RS08580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KOI47_RS08595	COG2124	cytochrome p450
KOI47_RS08615	COG0254	rRNA binding
KOI47_RS08620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KOI47_RS08635	COG0463	Glycosyl transferase, family 2
KOI47_RS08640	COG2890	protein-(glutamine-N5) methyltransferase activity
KOI47_RS08650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KOI47_RS08660	COG0356	it plays a direct role in the translocation of protons across the membrane
KOI47_RS08665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KOI47_RS08670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KOI47_RS08675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KOI47_RS08680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KOI47_RS08685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KOI47_RS08690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KOI47_RS08695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KOI47_RS08710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KOI47_RS08720	COG1280	lysine exporter protein (LysE YggA)
KOI47_RS08725	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KOI47_RS08725	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KOI47_RS08735	COG0765	amino acid transport
KOI47_RS08740	COG0765	amino acid transport
KOI47_RS08745	COG1126	abc transporter atp-binding protein
KOI47_RS08750	COG1024	Enoyl-CoA hydratase
KOI47_RS08760	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
KOI47_RS08780	COG2376	Dihydroxyacetone kinase
KOI47_RS08825	COG0596	Alpha beta hydrolase
KOI47_RS08835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KOI47_RS08840	COG3830	Belongs to the UPF0237 family
KOI47_RS08840	COG0560	Phosphoserine phosphatase
KOI47_RS08880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KOI47_RS08895	COG3191	aminopeptidase activity
KOI47_RS08915	COG1794	racemase activity, acting on amino acids and derivatives
KOI47_RS08925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KOI47_RS08940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KOI47_RS08945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KOI47_RS08980	COG0515	serine threonine protein kinase
KOI47_RS08980	COG2815	serine threonine protein kinase
KOI47_RS09000	COG0596	Alpha beta hydrolase
KOI47_RS09005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOI47_RS09010	COG0673	inositol 2-dehydrogenase activity
KOI47_RS09020	COG0483	inositol monophosphate 1-phosphatase activity
KOI47_RS09050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KOI47_RS09055	COG1032	radical SAM domain protein
KOI47_RS09085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KOI47_RS09105	COG3314	Sporulation integral membrane protein YlbJ
KOI47_RS09120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS09145	COG1309	transcriptional regulator
KOI47_RS09160	COG1316	TRANSCRIPTIONal
KOI47_RS09170	COG3903	Transcriptional regulator
KOI47_RS09170	COG3629	intracellular signal transduction
KOI47_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS09205	COG1063	alcohol dehydrogenase
KOI47_RS09215	COG0583	DNA-binding transcription factor activity
KOI47_RS09295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS09300	COG1120	ATPase activity
KOI47_RS09345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KOI47_RS09350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KOI47_RS09355	COG1914	H( )-stimulated, divalent metal cation uptake system
KOI47_RS09375	COG0626	cystathionine gamma-synthase activity
KOI47_RS09380	COG1522	sequence-specific DNA binding
KOI47_RS09385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KOI47_RS09390	COG0569	domain protein
KOI47_RS09405	COG1088	dTDP-glucose 4,6-dehydratase activity
KOI47_RS09410	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KOI47_RS09465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS09475	COG0640	Transcriptional regulator
KOI47_RS09505	COG1518	maintenance of DNA repeat elements
KOI47_RS09565	COG4991	sh3 domain protein
KOI47_RS09570	COG3540	Alkaline phosphatase
KOI47_RS09610	COG4221	oxidoreductase activity
KOI47_RS09610	COG3321	synthase
KOI47_RS09610	COG0604	alcohol dehydrogenase
KOI47_RS09610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS09630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOI47_RS09635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS09650	COG2130	NADP-dependent
KOI47_RS09685	COG0657	acetylesterase activity
KOI47_RS09720	COG3629	intracellular signal transduction
KOI47_RS09720	COG3903	Transcriptional regulator
KOI47_RS09725	COG3344	reverse transcriptase
KOI47_RS09805	COG0477	Major facilitator Superfamily
KOI47_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS09840	COG0577	efflux transmembrane transporter activity
KOI47_RS09840	COG1136	(ABC) transporter
KOI47_RS09910	COG0789	Transcriptional regulator
KOI47_RS09930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KOI47_RS09935	COG2271	Major facilitator Superfamily
KOI47_RS09940	COG0488	(ABC) transporter
KOI47_RS09945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KOI47_RS09950	COG0789	Transcriptional regulator
KOI47_RS09955	COG0789	Transcriptional regulator
KOI47_RS09975	COG0789	Transcriptional regulator
KOI47_RS10005	COG3973	AAA domain
KOI47_RS10015	COG0659	secondary active sulfate transmembrane transporter activity
KOI47_RS10190	COG1376	ErfK ybiS ycfS ynhG family protein
KOI47_RS10200	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KOI47_RS10205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KOI47_RS10220	COG0482	sulfurtransferase activity
KOI47_RS10230	COG0456	acetyltransferase
KOI47_RS10235	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS10250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KOI47_RS10255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KOI47_RS10255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KOI47_RS10260	COG0076	glutamate decarboxylase activity
KOI47_RS10275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KOI47_RS10295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KOI47_RS10300	COG0154	amidase activity
KOI47_RS10305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KOI47_RS10325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KOI47_RS10330	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KOI47_RS10360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KOI47_RS10380	COG3706	GGDEF domain
KOI47_RS10385	COG1349	DNA-binding transcription factor activity
KOI47_RS10390	COG0673	inositol 2-dehydrogenase activity
KOI47_RS10405	COG0395	ABC-type sugar transport system, permease component
KOI47_RS10410	COG3842	ATPase activity
KOI47_RS10420	COG1349	DNA-binding transcription factor activity
KOI47_RS10425	COG1470	cell adhesion involved in biofilm formation
KOI47_RS10425	COG0366	Alpha amylase catalytic
KOI47_RS10465	COG4166	transmembrane transport
KOI47_RS10485	COG0070	glutamate synthase
KOI47_RS10485	COG0069	glutamate synthase activity
KOI47_RS10485	COG0067	glutamate synthase
KOI47_RS10490	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS10500	COG3971	2-oxopent-4-enoate hydratase activity
KOI47_RS10505	COG0277	FAD linked oxidase domain protein
KOI47_RS10505	COG0247	lactate metabolic process
KOI47_RS10540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KOI47_RS10540	COG0235	Class ii aldolase
KOI47_RS10555	COG2226	methyltransferase
KOI47_RS10560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KOI47_RS10570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KOI47_RS10580	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KOI47_RS10615	COG0183	Belongs to the thiolase family
KOI47_RS10625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS10630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOI47_RS10635	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KOI47_RS10640	COG1879	ABC-type sugar transport system periplasmic component
KOI47_RS10645	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS10660	COG1609	Transcriptional regulator
KOI47_RS10665	COG2409	Drug exporters of the RND superfamily
KOI47_RS10670	COG1846	Transcriptional regulator
KOI47_RS10700	COG0058	SHG alpha-glucan phosphorylase activity
KOI47_RS10705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KOI47_RS10715	COG1119	ATPase activity
KOI47_RS10725	COG2226	methyltransferase
KOI47_RS10740	COG0640	Transcriptional regulator
KOI47_RS10750	COG0640	Transcriptional regulator
KOI47_RS10760	COG2197	response regulator
KOI47_RS10765	COG4585	Histidine kinase
KOI47_RS10780	COG4941	Belongs to the sigma-70 factor family
KOI47_RS10815	COG0596	Alpha beta hydrolase
KOI47_RS10835	COG0667	Aldo Keto reductase
KOI47_RS10860	COG2188	Transcriptional regulator
KOI47_RS10870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KOI47_RS10885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KOI47_RS10890	COG4106	trans-aconitate 2-methyltransferase activity
KOI47_RS10955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS10980	COG0791	NLP P60 protein
KOI47_RS10980	COG1388	LysM domain
KOI47_RS10980	COG3103	Sh3 type 3 domain protein
KOI47_RS10985	COG1957	nucleoside hydrolase
KOI47_RS10990	COG0110	maltose O-acetyltransferase activity
KOI47_RS11030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KOI47_RS11050	COG3250	beta-galactosidase activity
KOI47_RS11080	COG1307	EDD domain protein, DegV family
KOI47_RS11085	COG2086	electron transfer activity
KOI47_RS11090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KOI47_RS11125	COG1024	Enoyl-CoA hydratase
KOI47_RS11175	COG0531	amino acid
KOI47_RS11195	COG3104	oligopeptide transport
KOI47_RS11210	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS11220	COG2867	negative regulation of translational initiation
KOI47_RS11245	COG3321	synthase
KOI47_RS11245	COG0604	alcohol dehydrogenase
KOI47_RS11250	COG0477	Major facilitator Superfamily
KOI47_RS11265	COG0662	Cupin 2, conserved barrel domain protein
KOI47_RS11270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOI47_RS11275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOI47_RS11295	COG0367	asparagine synthase
KOI47_RS11305	COG2345	Transcriptional regulator
KOI47_RS11310	COG2132	Multicopper oxidase
KOI47_RS11325	COG0006	proline dipeptidase activity
KOI47_RS11330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KOI47_RS11335	COG0367	asparagine synthase
KOI47_RS11345	COG3629	intracellular signal transduction
KOI47_RS11355	COG4585	Histidine kinase
KOI47_RS11360	COG2197	response regulator
KOI47_RS11405	COG1796	DNA polymerase
KOI47_RS11405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KOI47_RS11420	COG2072	flavoprotein involved in K transport
KOI47_RS11425	COG0300	oxidoreductase activity
KOI47_RS11485	COG1929	Belongs to the glycerate kinase type-1 family
KOI47_RS11495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KOI47_RS11500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KOI47_RS11505	COG3485	protocatechuate 3,4-dioxygenase
KOI47_RS11510	COG3485	protocatechuate 3,4-dioxygenase
KOI47_RS11515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KOI47_RS11520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOI47_RS11525	COG1414	Transcriptional regulator
KOI47_RS11550	COG2205	protein histidine kinase activity
KOI47_RS11555	COG2770	Histidine kinase
KOI47_RS11555	COG2208	phosphoserine phosphatase activity
KOI47_RS11615	COG3962	Belongs to the TPP enzyme family
KOI47_RS11620	COG3718	enzyme involved in inositol metabolism
KOI47_RS11630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOI47_RS11640	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS11660	COG0673	inositol 2-dehydrogenase activity
KOI47_RS11695	COG0531	amino acid
KOI47_RS11705	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KOI47_RS11735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KOI47_RS11735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KOI47_RS11740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KOI47_RS11745	COG0509	glycine decarboxylation via glycine cleavage system
KOI47_RS11750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KOI47_RS11760	COG1760	l-serine dehydratase
KOI47_RS11765	COG2186	Transcriptional regulator
KOI47_RS11770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KOI47_RS11775	COG4122	O-methyltransferase activity
KOI47_RS11780	COG2207	Transcriptional regulator
KOI47_RS11785	COG0183	Belongs to the thiolase family
KOI47_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS11805	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS11820	COG4221	oxidoreductase activity
KOI47_RS11835	COG2814	Major facilitator Superfamily
KOI47_RS11870	COG1643	Atp-dependent helicase
KOI47_RS11880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KOI47_RS11880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KOI47_RS11885	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS11915	COG2814	Major facilitator Superfamily
KOI47_RS11920	COG3629	intracellular signal transduction
KOI47_RS11920	COG3903	Transcriptional regulator
KOI47_RS11950	COG2409	Drug exporters of the RND superfamily
KOI47_RS12000	COG0243	molybdopterin cofactor binding
KOI47_RS12005	COG0596	Alpha beta hydrolase
KOI47_RS12040	COG1129	ABC transporter
KOI47_RS12045	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS12050	COG1879	ABC-type sugar transport system periplasmic component
KOI47_RS12055	COG0673	inositol 2-dehydrogenase activity
KOI47_RS12060	COG3507	Belongs to the glycosyl hydrolase 43 family
KOI47_RS12105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KOI47_RS12105	COG2755	lipolytic protein G-D-S-L family
KOI47_RS12125	COG0252	asparaginase activity
KOI47_RS12170	COG3383	formate dehydrogenase (NAD+) activity
KOI47_RS12215	COG2124	cytochrome p450
KOI47_RS12225	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KOI47_RS12235	COG1940	carbohydrate kinase activity
KOI47_RS12235	COG1846	Transcriptional regulator
KOI47_RS12240	COG2115	Belongs to the xylose isomerase family
KOI47_RS12245	COG3409	Peptidoglycan-binding domain 1 protein
KOI47_RS12265	COG2345	Transcriptional regulator
KOI47_RS12290	COG0596	Alpha beta hydrolase
KOI47_RS12295	COG2814	Major facilitator Superfamily
KOI47_RS12315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KOI47_RS12340	COG1609	Transcriptional regulator
KOI47_RS12345	COG2223	nitrite transmembrane transporter activity
KOI47_RS12350	COG0629	single-stranded DNA binding
KOI47_RS12365	COG2902	Dehydrogenase
KOI47_RS12370	COG0824	Thioesterase
KOI47_RS12395	COG0366	Alpha amylase catalytic
KOI47_RS12405	COG0668	transmembrane transport
KOI47_RS12425	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KOI47_RS12435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KOI47_RS12515	COG0544	peptidyl-prolyl cis-trans isomerase activity
KOI47_RS12520	COG0740	serine-type endopeptidase activity
KOI47_RS12525	COG0740	serine-type endopeptidase activity
KOI47_RS12530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KOI47_RS12550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KOI47_RS12580	COG0525	valine-tRNA ligase activity
KOI47_RS12590	COG1309	transcriptional regulator
KOI47_RS12605	COG0285	dihydrofolate synthase activity
KOI47_RS12620	COG0105	UTP biosynthetic process
KOI47_RS12650	COG1404	Belongs to the peptidase S8 family
KOI47_RS12655	COG1530	ribonuclease E activity
KOI47_RS12660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KOI47_RS12665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KOI47_RS12670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KOI47_RS12685	COG0596	Alpha beta hydrolase
KOI47_RS12690	COG0477	Major facilitator Superfamily
KOI47_RS12700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KOI47_RS12705	COG0799	negative regulation of ribosome biogenesis
KOI47_RS12710	COG0406	alpha-ribazole phosphatase activity
KOI47_RS12715	COG2755	lipolytic protein G-D-S-L family
KOI47_RS12720	COG1307	EDD domain protein, DegV family
KOI47_RS12735	COG0577	efflux transmembrane transporter activity
KOI47_RS12735	COG1136	(ABC) transporter
KOI47_RS12745	COG4585	Histidine kinase
KOI47_RS12750	COG2197	response regulator
KOI47_RS12760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KOI47_RS12770	COG0268	Binds directly to 16S ribosomal RNA
KOI47_RS12790	COG0481	GTPase activity
KOI47_RS12800	COG2070	2-Nitropropane dioxygenase
KOI47_RS12810	COG0604	alcohol dehydrogenase
KOI47_RS12825	COG2732	(Barnase) inhibitor
KOI47_RS12840	COG1024	Enoyl-CoA hydratase
KOI47_RS12880	COG1966	Carbon starvation protein
KOI47_RS12890	COG0003	Pfam Anion-transporting ATPase
KOI47_RS12905	COG2197	response regulator
KOI47_RS12910	COG3851	Histidine kinase
KOI47_RS12915	COG2409	Drug exporters of the RND superfamily
KOI47_RS12920	COG1136	(ABC) transporter
KOI47_RS12920	COG0577	efflux transmembrane transporter activity
KOI47_RS12950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KOI47_RS12955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KOI47_RS12960	COG1953	Uracil, thiamine, allantoin
KOI47_RS12985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KOI47_RS12995	COG3903	Transcriptional regulator
KOI47_RS12995	COG3629	intracellular signal transduction
KOI47_RS13010	COG1420	regulation of RNA biosynthetic process
KOI47_RS13015	COG0484	heat shock protein binding
KOI47_RS13025	COG0537	adenosine 5'-monophosphoramidase activity
KOI47_RS13035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KOI47_RS13050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KOI47_RS13060	COG1381	Involved in DNA repair and RecF pathway recombination
KOI47_RS13065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KOI47_RS13075	COG0701	Predicted permease
KOI47_RS13105	COG0423	glycine-tRNA ligase activity
KOI47_RS13115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KOI47_RS13135	COG1595	DNA-templated transcription, initiation
KOI47_RS13150	COG4106	trans-aconitate 2-methyltransferase activity
KOI47_RS13165	COG2226	methyltransferase
KOI47_RS13200	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS13225	COG0596	Alpha beta hydrolase
KOI47_RS13235	COG5416	Lipopolysaccharide assembly protein A domain
KOI47_RS13240	COG0018	arginyl-trna synthetase
KOI47_RS13265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KOI47_RS13270	COG1716	ATPase activity
KOI47_RS13290	COG0596	Alpha beta hydrolase
KOI47_RS13320	COG0668	transmembrane transport
KOI47_RS13350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KOI47_RS13355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KOI47_RS13360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KOI47_RS13400	COG2197	response regulator
KOI47_RS13445	COG0779	Required for maturation of 30S ribosomal subunits
KOI47_RS13460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KOI47_RS13470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KOI47_RS13495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KOI47_RS13515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KOI47_RS13520	COG1185	polyribonucleotide nucleotidyltransferase activity
KOI47_RS13530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KOI47_RS13555	COG0697	spore germination
KOI47_RS13600	COG0515	serine threonine protein kinase
KOI47_RS13605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KOI47_RS13610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KOI47_RS13635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KOI47_RS13640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KOI47_RS13640	COG2755	lipolytic protein G-D-S-L family
KOI47_RS13645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KOI47_RS13655	COG1546	Belongs to the CinA family
KOI47_RS13655	COG1058	Belongs to the CinA family
KOI47_RS13660	COG1396	sequence-specific DNA binding
KOI47_RS13665	COG1842	Phage shock protein A
KOI47_RS13680	COG0167	dihydroorotate dehydrogenase activity
KOI47_RS13690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KOI47_RS13700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KOI47_RS13715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KOI47_RS13725	COG1305	Transglutaminase-like
KOI47_RS13735	COG0714	Associated with various cellular activities
KOI47_RS13760	COG2001	Belongs to the MraZ family
KOI47_RS13765	COG0275	rRNA processing
KOI47_RS13775	COG0768	penicillin binding
KOI47_RS13795	COG1022	Amp-dependent synthetase and ligase
KOI47_RS13825	COG1940	carbohydrate kinase activity
KOI47_RS13835	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KOI47_RS13860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KOI47_RS13865	COG1263	PTS System
KOI47_RS13870	COG2188	Transcriptional regulator
KOI47_RS13875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KOI47_RS13910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KOI47_RS13915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KOI47_RS13920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KOI47_RS13925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KOI47_RS13930	COG0346	lactoylglutathione lyase activity
KOI47_RS13950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KOI47_RS13955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KOI47_RS13985	COG0505	Belongs to the CarA family
KOI47_RS13995	COG0284	orotidine-5'-phosphate decarboxylase activity
KOI47_RS14005	COG0194	GDP metabolic process
KOI47_RS14010	COG1758	RNA polymerase activity
KOI47_RS14020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KOI47_RS14030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KOI47_RS14040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KOI47_RS14055	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KOI47_RS14090	COG1129	ABC transporter
KOI47_RS14095	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS14120	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
KOI47_RS14180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KOI47_RS14180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KOI47_RS14185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KOI47_RS14200	COG0708	Exodeoxyribonuclease III
KOI47_RS14205	COG0583	DNA-binding transcription factor activity
KOI47_RS14210	COG1113	amino acid transport
KOI47_RS14230	COG4977	sequence-specific DNA binding
KOI47_RS14240	COG0456	acetyltransferase
KOI47_RS14295	COG0322	excinuclease ABC activity
KOI47_RS14300	COG1660	Displays ATPase and GTPase activities
KOI47_RS14310	COG1481	regulation of sporulation
KOI47_RS14340	COG1280	lysine exporter protein (LysE YggA)
KOI47_RS14350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KOI47_RS14355	COG0126	phosphoglycerate kinase activity
KOI47_RS14360	COG0149	triose-phosphate isomerase activity
KOI47_RS14400	COG0363	glucosamine-6-phosphate deaminase activity
KOI47_RS14415	COG0166	Belongs to the GPI family
KOI47_RS14420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KOI47_RS14430	COG0109	protoheme IX farnesyltransferase activity
KOI47_RS14435	COG3973	AAA domain
KOI47_RS14435	COG3973	AAA domain
KOI47_RS14485	COG1131	(ABC) transporter
KOI47_RS14510	COG0396	ATPase activity
KOI47_RS14520	COG0822	iron-sulfur transferase activity
KOI47_RS14525	COG2151	metal-sulfur cluster biosynthetic enzyme
KOI47_RS14545	COG4585	Histidine kinase
KOI47_RS14550	COG2197	response regulator
KOI47_RS14555	COG2200	EAL domain
KOI47_RS14575	COG0488	(ABC) transporter
KOI47_RS14595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KOI47_RS14600	COG1316	TRANSCRIPTIONal
KOI47_RS14625	COG5001	Diguanylate cyclase
KOI47_RS14640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KOI47_RS14645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KOI47_RS14645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KOI47_RS14655	COG2072	flavoprotein involved in K transport
KOI47_RS14660	COG4689	acetoacetate decarboxylase
KOI47_RS14665	COG1024	Enoyl-CoA hydratase
KOI47_RS14720	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS14725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KOI47_RS14745	COG1309	transcriptional regulator
KOI47_RS14755	COG1595	DNA-templated transcription, initiation
KOI47_RS14765	COG1309	transcriptional regulator
KOI47_RS14770	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS14785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS14790	COG1309	transcriptional regulator
KOI47_RS14810	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS14815	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS14840	COG0484	heat shock protein binding
KOI47_RS14865	COG0154	amidase activity
KOI47_RS14880	COG0514	ATP-dependent DNA helicase (RecQ)
KOI47_RS14885	COG1129	ABC transporter
KOI47_RS14895	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS14910	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
KOI47_RS14925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KOI47_RS14945	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS15000	COG0657	acetylesterase activity
KOI47_RS15005	COG0667	Aldo Keto reductase
KOI47_RS15020	COG1414	Transcriptional regulator
KOI47_RS15035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KOI47_RS15040	COG1414	Transcriptional regulator
KOI47_RS15045	COG0028	Belongs to the TPP enzyme family
KOI47_RS15070	COG2249	NAD(P)H dehydrogenase (quinone) activity
KOI47_RS15075	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KOI47_RS15135	COG2319	Wd-40 repeat
KOI47_RS15135	COG4249	Peptidase C14 caspase catalytic subunit p20
KOI47_RS15140	COG5285	phytanoyl-CoA dioxygenase
KOI47_RS15210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KOI47_RS15220	COG3842	ATPase activity
KOI47_RS15245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KOI47_RS15255	COG1024	Enoyl-CoA hydratase
KOI47_RS15270	COG1357	PFAM Pentapeptide repeats (8 copies)
KOI47_RS15275	COG2318	DinB family
KOI47_RS15305	COG3591	Belongs to the peptidase S1B family
KOI47_RS15330	COG0297	glycogen (starch) synthase activity
KOI47_RS15345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KOI47_RS15355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KOI47_RS15370	COG4106	trans-aconitate 2-methyltransferase activity
KOI47_RS15410	COG0535	radical SAM domain protein
KOI47_RS15415	COG1266	CAAX protease self-immunity
KOI47_RS15420	COG1132	(ABC) transporter
KOI47_RS15445	COG0457	Tetratricopeptide repeat
KOI47_RS15500	COG1349	DNA-binding transcription factor activity
KOI47_RS15510	COG1105	Belongs to the carbohydrate kinase PfkB family
KOI47_RS15525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KOI47_RS15585	COG0604	alcohol dehydrogenase
KOI47_RS15585	COG3321	synthase
KOI47_RS15595	COG2226	methyltransferase
KOI47_RS15600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS15605	COG0583	DNA-binding transcription factor activity
KOI47_RS15615	COG3959	Transketolase, thiamine diphosphate binding domain
KOI47_RS15620	COG2124	cytochrome p450
KOI47_RS15675	COG1819	glycosyl
KOI47_RS15700	COG0667	Aldo Keto reductase
KOI47_RS15705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KOI47_RS15765	COG1063	alcohol dehydrogenase
KOI47_RS15790	COG0395	ABC-type sugar transport system, permease component
KOI47_RS15810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KOI47_RS15815	COG0028	Belongs to the TPP enzyme family
KOI47_RS15845	COG0709	Synthesizes selenophosphate from selenide and ATP
KOI47_RS15870	COG0437	4 iron, 4 sulfur cluster binding
KOI47_RS15905	COG1535	isochorismatase
KOI47_RS15905	COG3433	isochorismatase activity
KOI47_RS15910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KOI47_RS15915	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS15920	COG1169	isochorismate synthase
KOI47_RS15925	COG1021	2,3-dihydroxybenzoate-AMP ligase
KOI47_RS15930	COG3433	isochorismatase activity
KOI47_RS15930	COG1535	isochorismatase
KOI47_RS15935	COG2375	cellular response to nickel ion
KOI47_RS15945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS15950	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS15955	COG1120	ATPase activity
KOI47_RS15985	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS15995	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS16015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KOI47_RS16020	COG0300	oxidoreductase activity
KOI47_RS16025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KOI47_RS16080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOI47_RS16090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KOI47_RS16100	COG0713	ATP synthesis coupled electron transport
KOI47_RS16115	COG1007	ATP synthesis coupled electron transport
KOI47_RS16140	COG0028	Belongs to the TPP enzyme family
KOI47_RS16145	COG4948	Mandelate Racemase Muconate Lactonizing
KOI47_RS16150	COG0277	FAD linked oxidase domain protein
KOI47_RS16150	COG0247	lactate metabolic process
KOI47_RS16155	COG3387	PFAM Glycoside hydrolase 15-related
KOI47_RS16160	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KOI47_RS16160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KOI47_RS16175	COG1115	amino acid carrier protein
KOI47_RS16195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS16200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS16230	COG2226	methyltransferase
KOI47_RS16230	COG2867	negative regulation of translational initiation
KOI47_RS16245	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS16250	COG1022	Amp-dependent synthetase and ligase
KOI47_RS16265	COG2010	Cytochrome c
KOI47_RS16265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KOI47_RS16270	COG2080	2 iron, 2 sulfur cluster binding
KOI47_RS16315	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS16320	COG1879	ABC-type sugar transport system periplasmic component
KOI47_RS16340	COG1120	ATPase activity
KOI47_RS16345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KOI47_RS16385	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KOI47_RS16400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KOI47_RS16405	COG2957	Belongs to the agmatine deiminase family
KOI47_RS16410	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS16420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KOI47_RS16460	COG1132	(ABC) transporter
KOI47_RS16475	COG4585	Histidine kinase
KOI47_RS16640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS16650	COG1454	alcohol dehydrogenase
KOI47_RS16655	COG3485	protocatechuate 3,4-dioxygenase
KOI47_RS16735	COG3883	PFAM NLP P60 protein
KOI47_RS16735	COG0791	NLP P60 protein
KOI47_RS16860	COG3903	Transcriptional regulator
KOI47_RS16860	COG3629	intracellular signal transduction
KOI47_RS16975	COG3629	intracellular signal transduction
KOI47_RS16975	COG3903	Transcriptional regulator
KOI47_RS17020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KOI47_RS17085	COG3903	Transcriptional regulator
KOI47_RS17085	COG3629	intracellular signal transduction
KOI47_RS17105	COG3903	Transcriptional regulator
KOI47_RS17105	COG3629	intracellular signal transduction
KOI47_RS17235	COG0667	Aldo Keto reductase
KOI47_RS17240	COG1968	undecaprenyl-diphosphatase activity
KOI47_RS17250	COG0339	signal peptide processing
KOI47_RS17255	COG0039	L-malate dehydrogenase activity
KOI47_RS17280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KOI47_RS17295	COG0601	transmembrane transport
KOI47_RS17300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOI47_RS17325	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS17335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KOI47_RS17345	COG2223	nitrite transmembrane transporter activity
KOI47_RS17350	COG1228	amidohydrolase
KOI47_RS17355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KOI47_RS17380	COG2124	cytochrome p450
KOI47_RS17395	COG0300	oxidoreductase activity
KOI47_RS17405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KOI47_RS17450	COG1024	Enoyl-CoA hydratase
KOI47_RS17455	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS17485	COG2226	methyltransferase
KOI47_RS17490	COG0640	Transcriptional regulator
KOI47_RS17500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KOI47_RS17520	COG1619	proteins homologs of microcin C7 resistance protein MccF
KOI47_RS17585	COG4941	Belongs to the sigma-70 factor family
KOI47_RS17590	COG3795	YCII-related domain
KOI47_RS17600	COG0702	epimerase
KOI47_RS17640	COG4941	Belongs to the sigma-70 factor family
KOI47_RS17660	COG0640	Transcriptional regulator
KOI47_RS17665	COG3795	YCII-related domain
KOI47_RS17670	COG4941	Belongs to the sigma-70 factor family
KOI47_RS17680	COG0655	NAD(P)H dehydrogenase (quinone) activity
KOI47_RS17690	COG4941	Belongs to the sigma-70 factor family
KOI47_RS17695	COG3795	YCII-related domain
KOI47_RS17745	COG2124	cytochrome p450
KOI47_RS17750	COG3973	AAA domain
KOI47_RS17755	COG2124	cytochrome p450
KOI47_RS17760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KOI47_RS17770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KOI47_RS17775	COG4974	Belongs to the 'phage' integrase family
KOI47_RS17790	COG4941	Belongs to the sigma-70 factor family
KOI47_RS17795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KOI47_RS17800	COG2890	protein-(glutamine-N5) methyltransferase activity
KOI47_RS17805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KOI47_RS17810	COG4941	Belongs to the sigma-70 factor family
KOI47_RS17825	COG0740	serine-type endopeptidase activity
KOI47_RS17840	COG2814	Major facilitator Superfamily
KOI47_RS17865	COG0463	Glycosyl transferase, family 2
KOI47_RS17875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KOI47_RS17890	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS17930	COG1309	transcriptional regulator
KOI47_RS17950	COG3631	Ketosteroid isomerase-related protein
KOI47_RS17970	COG1136	(ABC) transporter
KOI47_RS17975	COG1136	(ABC) transporter
KOI47_RS18045	COG2936	dipeptidyl-peptidase activity
KOI47_RS18065	COG4552	Acetyltransferase involved in intracellular survival and related
KOI47_RS18085	COG1733	regulation of RNA biosynthetic process
KOI47_RS18115	COG1597	lipid kinase activity
KOI47_RS18120	COG0805	protein transport
KOI47_RS18135	COG2378	regulation of single-species biofilm formation
KOI47_RS18145	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KOI47_RS18150	COG1597	lipid kinase activity
KOI47_RS18155	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KOI47_RS18160	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
KOI47_RS18190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KOI47_RS18205	COG1222	aaa ATPase
KOI47_RS18230	COG0517	IMP dehydrogenase activity
KOI47_RS18230	COG1994	Peptidase M50
KOI47_RS18245	COG1192	Involved in chromosome partitioning
KOI47_RS18265	COG0140	phosphoribosyl-ATP diphosphatase activity
KOI47_RS18275	COG2264	protein methyltransferase activity
KOI47_RS18280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KOI47_RS18290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KOI47_RS18295	COG0488	(ABC) transporter
KOI47_RS18305	COG0215	cysteine-tRNA ligase activity
KOI47_RS18310	COG0789	Transcriptional regulator
KOI47_RS18340	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KOI47_RS18350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KOI47_RS18355	COG1309	transcriptional regulator
KOI47_RS18370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KOI47_RS18385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KOI47_RS18390	COG2304	oxidoreductase activity
KOI47_RS18400	COG0714	Associated with various cellular activities
KOI47_RS18410	COG3883	PFAM NLP P60 protein
KOI47_RS18410	COG0791	NLP P60 protein
KOI47_RS18425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KOI47_RS18440	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KOI47_RS18445	COG0121	glutamine amidotransferase
KOI47_RS18450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KOI47_RS18455	COG3572	ergothioneine biosynthetic process
KOI47_RS18460	COG0583	DNA-binding transcription factor activity
KOI47_RS18500	COG2814	Major facilitator Superfamily
KOI47_RS18530	COG1064	alcohol dehydrogenase
KOI47_RS18535	COG1309	transcriptional regulator
KOI47_RS18550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KOI47_RS18550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KOI47_RS18560	COG1309	transcriptional regulator
KOI47_RS18575	COG1716	ATPase activity
KOI47_RS18595	COG1024	Enoyl-CoA hydratase
KOI47_RS18605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KOI47_RS18605	COG1648	precorrin-2 dehydrogenase activity
KOI47_RS18615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KOI47_RS18620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KOI47_RS18630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KOI47_RS18655	COG2211	Major facilitator Superfamily
KOI47_RS18660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS18700	COG3226	Transcriptional regulator
KOI47_RS18720	COG1486	melibiose metabolic process
KOI47_RS18725	COG0395	ABC-type sugar transport system, permease component
KOI47_RS18730	COG1175	transmembrane transport
KOI47_RS18740	COG1940	carbohydrate kinase activity
KOI47_RS18740	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KOI47_RS18755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KOI47_RS18765	COG2409	Drug exporters of the RND superfamily
KOI47_RS18775	COG3275	phosphorelay sensor kinase activity
KOI47_RS18790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KOI47_RS18800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KOI47_RS18835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KOI47_RS18850	COG1120	ATPase activity
KOI47_RS18855	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS18860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS18875	COG1132	(ABC) transporter
KOI47_RS18880	COG2267	carboxylic ester hydrolase activity
KOI47_RS18885	COG2318	DinB family
KOI47_RS18895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS18900	COG4607	ABC-type enterochelin transport system periplasmic component
KOI47_RS18905	COG3486	L-lysine 6-monooxygenase (NADPH) activity
KOI47_RS18915	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
KOI47_RS18955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KOI47_RS18970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KOI47_RS18975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KOI47_RS19040	COG4175	Glycine betaine
KOI47_RS19040	COG0517	IMP dehydrogenase activity
KOI47_RS19045	COG4176	ABC-type proline glycine betaine transport system permease component
KOI47_RS19090	COG1472	Belongs to the glycosyl hydrolase 3 family
KOI47_RS19095	COG0395	ABC-type sugar transport system, permease component
KOI47_RS19100	COG1175	transmembrane transport
KOI47_RS19105	COG2182	Extracellular solute-binding protein
KOI47_RS19110	COG1744	ABC transporter substrate-binding protein PnrA-like
KOI47_RS19115	COG3845	ABC transporter
KOI47_RS19120	COG4603	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS19130	COG1335	isochorismatase
KOI47_RS19155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KOI47_RS19160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS19195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KOI47_RS19200	COG0179	Fumarylacetoacetate (FAA) hydrolase
KOI47_RS19205	COG0673	inositol 2-dehydrogenase activity
KOI47_RS19230	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS19235	COG1252	NADH dehydrogenase
KOI47_RS19250	COG4977	sequence-specific DNA binding
KOI47_RS19270	COG2084	Dehydrogenase
KOI47_RS19275	COG2084	Dehydrogenase
KOI47_RS19285	COG0702	epimerase
KOI47_RS19305	COG0640	Transcriptional regulator
KOI47_RS19360	COG0517	IMP dehydrogenase activity
KOI47_RS19360	COG4175	Glycine betaine
KOI47_RS19365	COG4176	ABC-type proline glycine betaine transport system permease component
KOI47_RS19390	COG1846	Transcriptional regulator
KOI47_RS19395	COG0038	chloride channel
KOI47_RS19405	COG0626	cystathionine gamma-synthase activity
KOI47_RS19410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS19420	COG0326	Molecular chaperone. Has ATPase activity
KOI47_RS19425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KOI47_RS19455	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS19465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KOI47_RS19470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KOI47_RS19475	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KOI47_RS19495	COG2271	Major facilitator Superfamily
KOI47_RS19530	COG0745	RESPONSE REGULATOR receiver
KOI47_RS19535	COG2205	protein histidine kinase activity
KOI47_RS19560	COG2826	transposase and inactivated derivatives, IS30 family
KOI47_RS19605	COG1674	ftsk spoiiie
KOI47_RS19640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KOI47_RS19645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KOI47_RS19650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KOI47_RS19670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KOI47_RS19685	COG0488	(ABC) transporter
KOI47_RS19705	COG1595	DNA-templated transcription, initiation
KOI47_RS19765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KOI47_RS19775	COG1793	dna ligase
KOI47_RS19790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KOI47_RS19795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS19805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KOI47_RS19815	COG2815	serine threonine protein kinase
KOI47_RS19815	COG0515	serine threonine protein kinase
KOI47_RS19825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KOI47_RS19840	COG3220	belongs to the UPF0276 family
KOI47_RS19850	COG3253	May function as heme-dependent peroxidase
KOI47_RS19855	COG1404	Belongs to the peptidase S8 family
KOI47_RS19865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KOI47_RS19875	COG2197	response regulator
KOI47_RS19885	COG0183	Belongs to the thiolase family
KOI47_RS19890	COG1250	3-hydroxyacyl-CoA dehydrogenase
KOI47_RS19890	COG1024	Enoyl-CoA hydratase
KOI47_RS19895	COG0702	epimerase
KOI47_RS19910	COG2205	protein histidine kinase activity
KOI47_RS19915	COG0745	RESPONSE REGULATOR receiver
KOI47_RS19920	COG2040	homocysteine
KOI47_RS19930	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS19945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOI47_RS19950	COG4608	Belongs to the ABC transporter superfamily
KOI47_RS19960	COG0747	negative chemotaxis
KOI47_RS19965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KOI47_RS19970	COG0531	amino acid
KOI47_RS19975	COG0569	domain protein
KOI47_RS20000	COG1280	lysine exporter protein (LysE YggA)
KOI47_RS20010	COG0756	dUTP diphosphatase activity
KOI47_RS20030	COG0483	inositol monophosphate 1-phosphatase activity
KOI47_RS20060	COG2197	response regulator
KOI47_RS20065	COG0531	amino acid
KOI47_RS20075	COG0174	glutamine synthetase
KOI47_RS20090	COG1940	carbohydrate kinase activity
KOI47_RS20095	COG4214	carbohydrate transport
KOI47_RS20105	COG4213	ABC transporter substrate-binding protein
KOI47_RS20125	COG2313	pseudouridylate synthase activity
KOI47_RS20155	COG2890	protein-(glutamine-N5) methyltransferase activity
KOI47_RS20160	COG1490	D-aminoacyl-tRNA deacylase activity
KOI47_RS20170	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KOI47_RS20170	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KOI47_RS20180	COG1522	sequence-specific DNA binding
KOI47_RS20185	COG1280	lysine exporter protein (LysE YggA)
KOI47_RS20195	COG2070	2-Nitropropane dioxygenase
KOI47_RS20205	COG1024	Enoyl-CoA hydratase
KOI47_RS20235	COG2124	cytochrome p450
KOI47_RS20240	COG0183	Belongs to the thiolase family
KOI47_RS20250	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS20290	COG0183	Belongs to the thiolase family
KOI47_RS20295	COG1309	transcriptional regulator
KOI47_RS20300	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS20305	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20310	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS20315	COG1024	Enoyl-CoA hydratase
KOI47_RS20320	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20325	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20330	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KOI47_RS20350	COG0346	lactoylglutathione lyase activity
KOI47_RS20355	COG2267	carboxylic ester hydrolase activity
KOI47_RS20360	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20370	COG1053	succinate dehydrogenase
KOI47_RS20385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KOI47_RS20390	COG2030	dehydratase
KOI47_RS20420	COG2030	dehydratase
KOI47_RS20425	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20430	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20435	COG0657	acetylesterase activity
KOI47_RS20440	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20445	COG1309	transcriptional regulator
KOI47_RS20455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS20465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KOI47_RS20465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KOI47_RS20465	COG1703	isobutyryl-CoA mutase activity
KOI47_RS20480	COG2018	Roadblock/LC7 domain
KOI47_RS20495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KOI47_RS20500	COG0019	diaminopimelate decarboxylase activity
KOI47_RS20505	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KOI47_RS20520	COG1566	PFAM secretion protein HlyD family protein
KOI47_RS20540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KOI47_RS20545	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS20555	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS20560	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KOI47_RS20560	COG1672	PFAM Archaeal ATPase
KOI47_RS20585	COG2027	D-alanyl-D-alanine carboxypeptidase
KOI47_RS20590	COG1946	Acyl-CoA thioesterase
KOI47_RS20625	COG0471	metal ion transport
KOI47_RS20630	COG2986	histidine ammonia-lyase
KOI47_RS20640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KOI47_RS20655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KOI47_RS20660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KOI47_RS20670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KOI47_RS20685	COG3511	phospholipase C
KOI47_RS20695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KOI47_RS20725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KOI47_RS20780	COG0601	transmembrane transport
KOI47_RS20790	COG1414	Transcriptional regulator
KOI47_RS20820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KOI47_RS20835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KOI47_RS20840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KOI47_RS20845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KOI47_RS20850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KOI47_RS20865	COG0632	four-way junction helicase activity
KOI47_RS20870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KOI47_RS20890	COG0217	transcriptional regulatory protein
KOI47_RS20895	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KOI47_RS20910	COG1396	sequence-specific DNA binding
KOI47_RS20925	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KOI47_RS20945	COG0438	transferase activity, transferring glycosyl groups
KOI47_RS20950	COG1560	Kdo2-lipid A biosynthetic process
KOI47_RS20965	COG2353	YceI-like domain
KOI47_RS20975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KOI47_RS21125	COG3629	intracellular signal transduction
KOI47_RS21125	COG3903	Transcriptional regulator
KOI47_RS21140	COG2192	nodulation
KOI47_RS21155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS21160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS21165	COG3629	intracellular signal transduction
KOI47_RS21165	COG3903	Transcriptional regulator
KOI47_RS21180	COG3706	GGDEF domain
KOI47_RS21215	COG1233	COG1233 Phytoene dehydrogenase and related
KOI47_RS21225	COG3547	Transposase (IS116 IS110 IS902 family)
KOI47_RS21255	COG2814	Major facilitator Superfamily
KOI47_RS21300	COG2124	cytochrome p450
KOI47_RS21310	COG2124	cytochrome p450
KOI47_RS21320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS21360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS21360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS21370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS21370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS21390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOI47_RS21395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KOI47_RS21400	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS21415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOI47_RS21425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOI47_RS21430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KOI47_RS21440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KOI47_RS21460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KOI47_RS21465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KOI47_RS21485	COG0583	DNA-binding transcription factor activity
KOI47_RS21490	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS21510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS21525	COG3321	synthase
KOI47_RS21525	COG0604	alcohol dehydrogenase
KOI47_RS21530	COG0604	alcohol dehydrogenase
KOI47_RS21530	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS21530	COG3321	synthase
KOI47_RS21550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KOI47_RS21560	COG1472	Belongs to the glycosyl hydrolase 3 family
KOI47_RS21575	COG3835	regulator
KOI47_RS21620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KOI47_RS21625	COG1802	Transcriptional regulator
KOI47_RS21650	COG1414	Transcriptional regulator
KOI47_RS21660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KOI47_RS21670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KOI47_RS21690	COG0483	inositol monophosphate 1-phosphatase activity
KOI47_RS21695	COG4195	phage-related replication protein
KOI47_RS21730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KOI47_RS21740	COG0577	efflux transmembrane transporter activity
KOI47_RS21740	COG1136	(ABC) transporter
KOI47_RS21745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KOI47_RS21765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOI47_RS21770	COG2813	Specifically methylates the guanine in position
KOI47_RS21775	COG2124	cytochrome p450
KOI47_RS21780	COG0330	HflC and HflK could
KOI47_RS21845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KOI47_RS21855	COG2212	antiporter activity
KOI47_RS21865	COG0651	ATP synthesis coupled electron transport
KOI47_RS21870	COG1006	Multisubunit Na H antiporter MnhC subunit
KOI47_RS21875	COG2111	Na H antiporter
KOI47_RS21880	COG2111	Na H antiporter
KOI47_RS21880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KOI47_RS21890	COG0475	glutathione-regulated potassium exporter activity
KOI47_RS21905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KOI47_RS21935	COG0494	nUDIX hydrolase
KOI47_RS21940	COG0504	CTP synthase activity
KOI47_RS21945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KOI47_RS21965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KOI47_RS21980	COG0647	UMP catabolic process
KOI47_RS22005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KOI47_RS22010	COG2094	Belongs to the DNA glycosylase MPG family
KOI47_RS22015	COG0165	Argininosuccinate lyase
KOI47_RS22020	COG0137	argininosuccinate synthase activity
KOI47_RS22025	COG1438	arginine binding
KOI47_RS22035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KOI47_RS22040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KOI47_RS22045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KOI47_RS22050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KOI47_RS22085	COG0072	phenylalanine-tRNA ligase activity
KOI47_RS22085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KOI47_RS22090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KOI47_RS22095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOI47_RS22100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KOI47_RS22105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KOI47_RS22125	COG0251	oxidation-reduction process
KOI47_RS22130	COG1414	Transcriptional regulator
KOI47_RS22145	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
KOI47_RS22150	COG2610	gluconate transmembrane transporter activity
KOI47_RS22155	COG2706	6-phosphogluconolactonase activity
KOI47_RS22165	COG1175	transmembrane transport
KOI47_RS22170	COG0395	ABC-type sugar transport system, permease component
KOI47_RS22175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KOI47_RS22185	COG3290	protein histidine kinase activity
KOI47_RS22190	COG1301	dicarboxylic acid transport
KOI47_RS22205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KOI47_RS22220	COG0596	Alpha beta hydrolase
KOI47_RS22225	COG4221	oxidoreductase activity
KOI47_RS22240	COG1131	(ABC) transporter
KOI47_RS22280	COG4585	Histidine kinase
KOI47_RS22285	COG2197	response regulator
KOI47_RS22295	COG1309	transcriptional regulator
KOI47_RS22300	COG2267	carboxylic ester hydrolase activity
KOI47_RS22330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KOI47_RS22335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KOI47_RS22350	COG1070	Carbohydrate kinase
KOI47_RS22355	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
KOI47_RS22360	COG1609	Transcriptional regulator
KOI47_RS22390	COG1131	(ABC) transporter
KOI47_RS22455	COG4585	Histidine kinase
KOI47_RS22460	COG2197	response regulator
KOI47_RS22465	COG0237	dephospho-CoA kinase activity
KOI47_RS22465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KOI47_RS22475	COG0539	negative regulation of cytoplasmic translation
KOI47_RS22480	COG2226	methyltransferase
KOI47_RS22495	COG1511	domain protein
KOI47_RS22510	COG0346	lactoylglutathione lyase activity
KOI47_RS22515	COG2207	Transcriptional regulator
KOI47_RS22530	COG0583	DNA-binding transcription factor activity
KOI47_RS22575	COG0582	viral genome integration into host DNA
KOI47_RS22700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KOI47_RS22755	COG4974	Belongs to the 'phage' integrase family
KOI47_RS22790	COG0604	alcohol dehydrogenase
KOI47_RS22810	COG2226	methyltransferase
KOI47_RS22875	COG4555	ABC transporter
KOI47_RS22890	COG2124	cytochrome p450
KOI47_RS22900	COG2124	cytochrome p450
KOI47_RS22905	COG0367	asparagine synthase
KOI47_RS22955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOI47_RS22960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KOI47_RS22965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KOI47_RS22970	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KOI47_RS22975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KOI47_RS23010	COG4821	SIS domain
KOI47_RS23015	COG0363	glucosamine-6-phosphate deaminase activity
KOI47_RS23040	COG0395	ABC-type sugar transport system, permease component
KOI47_RS23050	COG1609	Transcriptional regulator
KOI47_RS23065	COG0246	Mannitol dehydrogenase
KOI47_RS23075	COG4948	Mandelate Racemase Muconate Lactonizing
KOI47_RS23080	COG3265	gluconokinase activity
KOI47_RS23135	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS23140	COG5479	isomerase activity
KOI47_RS23140	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KOI47_RS23150	COG0477	Major facilitator Superfamily
KOI47_RS23170	COG1404	Belongs to the peptidase S8 family
KOI47_RS23215	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KOI47_RS23225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KOI47_RS23230	COG0583	DNA-binding transcription factor activity
KOI47_RS23235	COG1595	DNA-templated transcription, initiation
KOI47_RS23265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KOI47_RS23275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KOI47_RS23280	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KOI47_RS23305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KOI47_RS23310	COG2239	Acts as a magnesium transporter
KOI47_RS23315	COG2239	Acts as a magnesium transporter
KOI47_RS23320	COG1253	flavin adenine dinucleotide binding
KOI47_RS23370	COG0549	Belongs to the carbamate kinase family
KOI47_RS23375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KOI47_RS23385	COG0531	amino acid
KOI47_RS23405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KOI47_RS23425	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS23470	COG2192	nodulation
KOI47_RS23475	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KOI47_RS23480	COG0859	PFAM glycosyl transferase family 9
KOI47_RS23485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KOI47_RS23490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KOI47_RS23490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KOI47_RS23505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KOI47_RS23535	COG3629	intracellular signal transduction
KOI47_RS23535	COG3903	Transcriptional regulator
KOI47_RS23555	COG3251	PFAM MbtH domain protein
KOI47_RS23575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KOI47_RS23585	COG0577	efflux transmembrane transporter activity
KOI47_RS23585	COG1136	(ABC) transporter
KOI47_RS23615	COG4948	Mandelate Racemase Muconate Lactonizing
KOI47_RS23630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS23660	COG0366	Alpha amylase catalytic
KOI47_RS23665	COG0395	ABC-type sugar transport system, permease component
KOI47_RS23670	COG1175	transmembrane transport
KOI47_RS23685	COG3344	reverse transcriptase
KOI47_RS23745	COG0416	fatty acid biosynthetic process
KOI47_RS23785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KOI47_RS23790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS23805	COG2814	Major facilitator Superfamily
KOI47_RS23845	COG0559	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS23850	COG0559	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS23860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
KOI47_RS23885	COG0673	inositol 2-dehydrogenase activity
KOI47_RS23900	COG0438	transferase activity, transferring glycosyl groups
KOI47_RS23905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KOI47_RS23940	COG2244	polysaccharide biosynthetic process
KOI47_RS23975	COG1215	transferase activity, transferring glycosyl groups
KOI47_RS23985	COG0745	RESPONSE REGULATOR receiver
KOI47_RS23990	COG2205	protein histidine kinase activity
KOI47_RS24015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KOI47_RS24015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KOI47_RS24020	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
KOI47_RS24030	COG0789	Transcriptional regulator
KOI47_RS24055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS24115	COG0542	response to heat
KOI47_RS24145	COG1940	carbohydrate kinase activity
KOI47_RS24145	COG1846	Transcriptional regulator
KOI47_RS24170	COG0667	Aldo Keto reductase
KOI47_RS24185	COG0248	Ppx GppA phosphatase
KOI47_RS24220	COG3344	reverse transcriptase
KOI47_RS24230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KOI47_RS24235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KOI47_RS24255	COG0745	RESPONSE REGULATOR receiver
KOI47_RS24260	COG5002	protein histidine kinase activity
KOI47_RS24270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KOI47_RS24310	COG1799	cell septum assembly
KOI47_RS24320	COG1496	oxidoreductase activity
KOI47_RS24340	COG2318	DinB family
KOI47_RS24350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KOI47_RS24355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KOI47_RS24365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KOI47_RS24370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KOI47_RS24425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KOI47_RS24430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KOI47_RS24440	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS24460	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS24465	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS24470	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS24490	COG1609	Transcriptional regulator
KOI47_RS24495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KOI47_RS24505	COG0123	including yeast histone deacetylase and acetoin utilization protein
KOI47_RS24515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KOI47_RS24520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KOI47_RS24555	COG2936	dipeptidyl-peptidase activity
KOI47_RS24585	COG0300	oxidoreductase activity
KOI47_RS24620	COG2321	neutral zinc metallopeptidase
KOI47_RS24630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KOI47_RS24640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KOI47_RS24700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KOI47_RS24710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KOI47_RS24720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KOI47_RS24730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KOI47_RS24740	COG1196	nuclear chromosome segregation
KOI47_RS24745	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS24750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KOI47_RS24765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KOI47_RS24795	COG1802	Transcriptional regulator
KOI47_RS24800	COG0045	succinate-CoA ligase (ADP-forming) activity
KOI47_RS24845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KOI47_RS24850	COG1126	abc transporter atp-binding protein
KOI47_RS24855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOI47_RS24860	COG0765	amino acid transport
KOI47_RS24865	COG0765	amino acid transport
KOI47_RS24895	COG0800	Aldolase
KOI47_RS24910	COG0657	acetylesterase activity
KOI47_RS24915	COG2137	regulation of response to DNA damage stimulus
KOI47_RS24920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KOI47_RS24930	COG0443	Heat shock 70 kDa protein
KOI47_RS24935	COG1201	RNA secondary structure unwinding
KOI47_RS24955	COG2813	Specifically methylates the guanine in position
KOI47_RS24960	COG2318	DinB family
KOI47_RS24965	COG1819	glycosyl
KOI47_RS24975	COG0242	peptide deformylase activity
KOI47_RS25030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KOI47_RS25035	COG0142	geranyltranstransferase activity
KOI47_RS25040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS25075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KOI47_RS25110	COG0395	ABC-type sugar transport system, permease component
KOI47_RS25130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KOI47_RS25145	COG0070	glutamate synthase
KOI47_RS25145	COG0069	glutamate synthase activity
KOI47_RS25145	COG0067	glutamate synthase
KOI47_RS25165	COG0395	ABC-type sugar transport system, permease component
KOI47_RS25185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS25190	COG1120	ATPase activity
KOI47_RS25195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KOI47_RS25200	COG0159	tryptophan synthase activity
KOI47_RS25205	COG0133	tryptophan synthase activity
KOI47_RS25210	COG0134	indole-3-glycerol-phosphate synthase activity
KOI47_RS25220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KOI47_RS25230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KOI47_RS25240	COG0107	imidazoleglycerol-phosphate synthase activity
KOI47_RS25245	COG1309	transcriptional regulator
KOI47_RS25260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KOI47_RS25265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KOI47_RS25275	COG3958	Transketolase
KOI47_RS25280	COG3959	Transketolase, thiamine diphosphate binding domain
KOI47_RS25285	COG0789	Transcriptional regulator
KOI47_RS25295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KOI47_RS25315	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
KOI47_RS25325	COG1309	transcriptional regulator
KOI47_RS25330	COG2409	Drug exporters of the RND superfamily
KOI47_RS25340	COG0131	Imidazoleglycerol-phosphate dehydratase
KOI47_RS25345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KOI47_RS25350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KOI47_RS25360	COG2197	response regulator
KOI47_RS25365	COG0157	Belongs to the NadC ModD family
KOI47_RS25370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KOI47_RS25375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KOI47_RS25385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KOI47_RS25400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KOI47_RS25405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KOI47_RS25410	COG0659	secondary active sulfate transmembrane transporter activity
KOI47_RS25415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KOI47_RS25430	COG0438	transferase activity, transferring glycosyl groups
KOI47_RS25435	COG0791	NLP P60 protein
KOI47_RS25435	COG3103	Sh3 type 3 domain protein
KOI47_RS25435	COG1388	LysM domain
KOI47_RS25450	COG0791	NLP P60 protein
KOI47_RS25450	COG1388	LysM domain
KOI47_RS25450	COG3103	Sh3 type 3 domain protein
KOI47_RS25470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KOI47_RS25485	COG1845	cytochrome c oxidase, subunit III
KOI47_RS25495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KOI47_RS25500	COG0586	Pfam SNARE associated Golgi protein
KOI47_RS25520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KOI47_RS25540	COG0477	Major facilitator Superfamily
KOI47_RS25555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KOI47_RS25580	COG0667	Aldo Keto reductase
KOI47_RS25585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KOI47_RS25595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KOI47_RS25630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KOI47_RS25635	COG0508	dehydrogenase complex catalyzes the overall conversion of
KOI47_RS25660	COG0321	lipoyl(octanoyl) transferase activity
KOI47_RS25695	COG3250	beta-galactosidase activity
KOI47_RS25720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KOI47_RS25725	COG0586	Pfam SNARE associated Golgi protein
KOI47_RS25735	COG1309	transcriptional regulator
KOI47_RS25740	COG1131	(ABC) transporter
KOI47_RS25745	COG3559	Exporter of polyketide antibiotics
KOI47_RS25760	COG1376	ErfK ybiS ycfS ynhG family protein
KOI47_RS25765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KOI47_RS25775	COG0587	DNA-directed DNA polymerase activity
KOI47_RS25800	COG2018	Roadblock/LC7 domain
KOI47_RS25820	COG1278	Cold shock
KOI47_RS25840	COG3250	beta-galactosidase activity
KOI47_RS25860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KOI47_RS25870	COG0668	transmembrane transport
KOI47_RS25885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KOI47_RS25890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KOI47_RS25940	COG1309	transcriptional regulator
KOI47_RS25960	COG0446	pyridine nucleotide-disulphide oxidoreductase
KOI47_RS25960	COG1902	pentaerythritol trinitrate reductase activity
KOI47_RS25965	COG0789	Transcriptional regulator
KOI47_RS25970	COG2814	Major facilitator Superfamily
KOI47_RS25980	COG2197	response regulator
KOI47_RS25990	COG1733	regulation of RNA biosynthetic process
KOI47_RS25995	COG3226	Transcriptional regulator
KOI47_RS26020	COG0442	prolyl-tRNA aminoacylation
KOI47_RS26030	COG3022	response to hydroperoxide
KOI47_RS26045	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
KOI47_RS26045	COG1672	PFAM Archaeal ATPase
KOI47_RS26060	COG0156	8-amino-7-oxononanoate synthase activity
KOI47_RS26075	COG1492	cobalamin metabolic process
KOI47_RS26105	COG2807	transmembrane transport
KOI47_RS26110	COG2186	Transcriptional regulator
KOI47_RS26135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KOI47_RS26140	COG0750	zinc metalloprotease
KOI47_RS26145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KOI47_RS26175	COG0513	Belongs to the DEAD box helicase family
KOI47_RS26195	COG0583	DNA-binding transcription factor activity
KOI47_RS26200	COG3706	GGDEF domain
KOI47_RS26215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KOI47_RS26240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KOI47_RS26255	COG0233	cytoplasmic translational termination
KOI47_RS26260	COG0528	UMP kinase activity
KOI47_RS26265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KOI47_RS26270	COG0052	Belongs to the universal ribosomal protein uS2 family
KOI47_RS26280	COG1191	sigma factor activity
KOI47_RS26310	COG0792	nuclease activity
KOI47_RS26320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KOI47_RS26325	COG0681	Belongs to the peptidase S26 family
KOI47_RS26330	COG0335	large ribosomal subunit rRNA binding
KOI47_RS26335	COG0336	Belongs to the RNA methyltransferase TrmD family
KOI47_RS26350	COG0228	four-way junction DNA binding
KOI47_RS26375	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KOI47_RS26385	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KOI47_RS26410	COG0667	Aldo Keto reductase
KOI47_RS26415	COG4266	Belongs to the allantoicase family
KOI47_RS26420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KOI47_RS26425	COG3960	tartronate-semialdehyde synthase activity
KOI47_RS26430	COG2084	Dehydrogenase
KOI47_RS26435	COG3622	Belongs to the hyi family
KOI47_RS26450	COG2351	hydroxyisourate hydrolase activity
KOI47_RS26460	COG2233	PERMEase
KOI47_RS26465	COG2267	carboxylic ester hydrolase activity
KOI47_RS26475	COG2252	PERMEase
KOI47_RS26480	COG0590	tRNA wobble adenosine to inosine editing
KOI47_RS26485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KOI47_RS26505	COG3835	regulator
KOI47_RS26510	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KOI47_RS26525	COG1316	TRANSCRIPTIONal
KOI47_RS26535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KOI47_RS26540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KOI47_RS26565	COG1254	Belongs to the acylphosphatase family
KOI47_RS26585	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KOI47_RS26595	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KOI47_RS26605	COG1940	carbohydrate kinase activity
KOI47_RS26625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KOI47_RS26630	COG0571	ribonuclease III activity
KOI47_RS26635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KOI47_RS26655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KOI47_RS26660	COG0742	ribosomal rna small subunit methyltransferase
KOI47_RS26665	COG3973	AAA domain
KOI47_RS26670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS26685	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KOI47_RS26705	COG1404	Belongs to the peptidase S8 family
KOI47_RS26710	COG0596	Alpha beta hydrolase
KOI47_RS26720	COG1461	Dihydroxyacetone kinase
KOI47_RS26725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KOI47_RS26730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KOI47_RS26755	COG1181	Belongs to the D-alanine--D-alanine ligase family
KOI47_RS26760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS26775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KOI47_RS26785	COG1920	GTP binding
KOI47_RS26805	COG0066	3-isopropylmalate dehydratase activity
KOI47_RS26810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KOI47_RS26840	COG2823	Periplasmic or secreted lipoprotein
KOI47_RS26840	COG1652	LysM domain
KOI47_RS26860	COG1011	Hydrolase
KOI47_RS26865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KOI47_RS26875	COG0179	Fumarylacetoacetate (FAA) hydrolase
KOI47_RS26885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KOI47_RS26910	COG0473	3-isopropylmalate dehydrogenase activity
KOI47_RS26915	COG1404	Belongs to the peptidase S8 family
KOI47_RS26920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KOI47_RS26925	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS26935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KOI47_RS26940	COG0440	acetolactate synthase activity
KOI47_RS26955	COG0129	dihydroxy-acid dehydratase activity
KOI47_RS27050	COG2188	Transcriptional regulator
KOI47_RS27095	COG1695	Transcriptional regulator
KOI47_RS27105	COG1278	Cold shock
KOI47_RS27110	COG1278	Cold shock
KOI47_RS27115	COG3547	Transposase (IS116 IS110 IS902 family)
KOI47_RS27125	COG0596	Alpha beta hydrolase
KOI47_RS27140	COG0584	glycerophosphoryl diester phosphodiesterase
KOI47_RS27155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS27215	COG3344	reverse transcriptase
KOI47_RS27255	COG4336	lyase activity
KOI47_RS27270	COG0435	Glutathione S-transferase
KOI47_RS27290	COG0596	Alpha beta hydrolase
KOI47_RS27295	COG0667	Aldo Keto reductase
KOI47_RS27305	COG2124	cytochrome p450
KOI47_RS27315	COG0154	amidase activity
KOI47_RS27350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KOI47_RS27355	COG0473	3-isopropylmalate dehydrogenase activity
KOI47_RS27365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KOI47_RS27375	COG0667	Aldo Keto reductase
KOI47_RS27385	COG0028	Belongs to the TPP enzyme family
KOI47_RS27390	COG1250	3-hydroxyacyl-CoA dehydrogenase
KOI47_RS27390	COG1024	Enoyl-CoA hydratase
KOI47_RS27395	COG0183	Belongs to the thiolase family
KOI47_RS27400	COG1309	transcriptional regulator
KOI47_RS27405	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS27410	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS27440	COG2826	transposase and inactivated derivatives, IS30 family
KOI47_RS27460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KOI47_RS27475	COG0583	DNA-binding transcription factor activity
KOI47_RS27485	COG4221	oxidoreductase activity
KOI47_RS27500	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS27510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KOI47_RS27515	COG2755	lipolytic protein G-D-S-L family
KOI47_RS27535	COG2508	Transcriptional regulator
KOI47_RS27535	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KOI47_RS27540	COG0686	Belongs to the AlaDH PNT family
KOI47_RS27555	COG1132	(ABC) transporter
KOI47_RS27565	COG3209	COG3209 Rhs family protein
KOI47_RS27580	COG0567	Dehydrogenase, E1 component
KOI47_RS27580	COG0508	dehydrogenase complex catalyzes the overall conversion of
KOI47_RS27605	COG1174	glycine betaine transport
KOI47_RS27610	COG0517	IMP dehydrogenase activity
KOI47_RS27610	COG1125	glycine betaine transport
KOI47_RS27620	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KOI47_RS27635	COG0406	alpha-ribazole phosphatase activity
KOI47_RS27650	COG1597	lipid kinase activity
KOI47_RS27670	COG1595	DNA-templated transcription, initiation
KOI47_RS27675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KOI47_RS27695	COG1162	GTPase activity
KOI47_RS27730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOI47_RS27780	COG0653	protein targeting
KOI47_RS27785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KOI47_RS27795	COG5401	PFAM Sporulation and spore germination
KOI47_RS27800	COG5002	protein histidine kinase activity
KOI47_RS27805	COG0745	RESPONSE REGULATOR receiver
KOI47_RS27810	COG1414	Transcriptional regulator
KOI47_RS27845	COG0531	amino acid
KOI47_RS27855	COG1482	cell wall glycoprotein biosynthetic process
KOI47_RS27865	COG2835	tetraacyldisaccharide 4'-kinase activity
KOI47_RS27870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KOI47_RS27910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KOI47_RS27920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KOI47_RS27925	COG0601	transmembrane transport
KOI47_RS27935	COG0747	negative chemotaxis
KOI47_RS27940	COG1217	gtp-binding protein TYPA
KOI47_RS27955	COG0180	Tryptophanyl-tRNA synthetase
KOI47_RS27960	COG0494	nUDIX hydrolase
KOI47_RS27970	COG0745	RESPONSE REGULATOR receiver
KOI47_RS27980	COG1131	(ABC) transporter
KOI47_RS27990	COG3842	ATPase activity
KOI47_RS28005	COG2154	pterin-4-alpha-carbinolamine dehydratase
KOI47_RS28030	COG0012	GTP binding
KOI47_RS28050	COG0419	ATPase involved in DNA repair
KOI47_RS28055	COG0420	3'-5' exonuclease activity
KOI47_RS28070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KOI47_RS28080	COG1570	exodeoxyribonuclease VII activity
KOI47_RS28090	COG1722	exodeoxyribonuclease VII activity
KOI47_RS28105	COG0492	ferredoxin-NADP+ reductase activity
KOI47_RS28110	COG0114	fumarate hydratase activity
KOI47_RS28120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS28140	COG1793	dna ligase
KOI47_RS28160	COG0477	Major facilitator Superfamily
KOI47_RS28165	COG2828	Protein conserved in bacteria
KOI47_RS28175	COG1131	(ABC) transporter
KOI47_RS28185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KOI47_RS28215	COG0483	inositol monophosphate 1-phosphatase activity
KOI47_RS28245	COG1331	Highly conserved protein containing a thioredoxin domain
KOI47_RS28250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KOI47_RS28255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KOI47_RS28270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KOI47_RS28280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KOI47_RS28285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KOI47_RS28295	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KOI47_RS28300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KOI47_RS28340	COG0737	Belongs to the 5'-nucleotidase family
KOI47_RS28345	COG0183	Belongs to the thiolase family
KOI47_RS28395	COG1595	DNA-templated transcription, initiation
KOI47_RS28405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KOI47_RS28465	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS28480	COG1132	(ABC) transporter
KOI47_RS28490	COG0439	Biotin carboxylase
KOI47_RS28495	COG0477	Major facilitator Superfamily
KOI47_RS28505	COG0072	phenylalanine-tRNA ligase activity
KOI47_RS28505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KOI47_RS28510	COG1280	lysine exporter protein (LysE YggA)
KOI47_RS28515	COG0702	epimerase
KOI47_RS28535	COG1349	DNA-binding transcription factor activity
KOI47_RS28540	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS28545	COG1172	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS28550	COG1129	ABC transporter
KOI47_RS28555	COG1879	ABC-type sugar transport system periplasmic component
KOI47_RS28560	COG3250	beta-galactosidase activity
KOI47_RS28620	COG0577	efflux transmembrane transporter activity
KOI47_RS28620	COG1136	(ABC) transporter
KOI47_RS28625	COG1136	(ABC) transporter
KOI47_RS28630	COG1309	transcriptional regulator
KOI47_RS28635	COG0477	Major facilitator Superfamily
KOI47_RS28670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KOI47_RS28745	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KOI47_RS29045	COG2826	transposase and inactivated derivatives, IS30 family
KOI47_RS29070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KOI47_RS29080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KOI47_RS29085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KOI47_RS29110	COG0315	cyclic pyranopterin monophosphate synthase activity
KOI47_RS29110	COG0521	Mo-molybdopterin cofactor biosynthetic process
KOI47_RS29120	COG5002	protein histidine kinase activity
KOI47_RS29125	COG0745	RESPONSE REGULATOR receiver
KOI47_RS29160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KOI47_RS29170	COG1349	DNA-binding transcription factor activity
KOI47_RS29185	COG2860	membrane
KOI47_RS29190	COG2197	response regulator
KOI47_RS29210	COG1595	DNA-templated transcription, initiation
KOI47_RS29215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KOI47_RS29250	COG0640	Transcriptional regulator
KOI47_RS29255	COG0671	phosphoesterase, PA-phosphatase related
KOI47_RS29280	COG0697	spore germination
KOI47_RS29320	COG0384	phenazine biosynthesis protein PhzF
KOI47_RS29330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS29335	COG2267	carboxylic ester hydrolase activity
KOI47_RS29340	COG1752	Esterase of the alpha-beta hydrolase superfamily
KOI47_RS29345	COG2319	Wd-40 repeat
KOI47_RS29350	COG4585	Histidine kinase
KOI47_RS29355	COG2197	response regulator
KOI47_RS29360	COG1737	Transcriptional regulator
KOI47_RS29365	COG0436	Aminotransferase
KOI47_RS29385	COG1024	Enoyl-CoA hydratase
KOI47_RS29390	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS29395	COG1309	transcriptional regulator
KOI47_RS29415	COG1169	isochorismate synthase
KOI47_RS29455	COG0277	FAD linked oxidase domain protein
KOI47_RS29470	COG4152	abc transporter atp-binding protein
KOI47_RS29475	COG1668	transmembrane transport
KOI47_RS29495	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS29500	COG1228	amidohydrolase
KOI47_RS29505	COG2017	converts alpha-aldose to the beta-anomer
KOI47_RS29530	COG3903	Transcriptional regulator
KOI47_RS29530	COG3629	intracellular signal transduction
KOI47_RS29550	COG0259	pyridoxamine-phosphate oxidase activity
KOI47_RS29580	COG1131	(ABC) transporter
KOI47_RS29595	COG2197	response regulator
KOI47_RS29675	COG3344	reverse transcriptase
KOI47_RS29685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOI47_RS29700	COG5398	heme oxygenase
KOI47_RS29720	COG2252	PERMEase
KOI47_RS29745	COG2814	Major facilitator Superfamily
KOI47_RS29755	COG1278	Cold shock
KOI47_RS29765	COG0546	phosphoglycolate phosphatase activity
KOI47_RS29775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KOI47_RS29785	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS29795	COG3304	Inner membrane component domain
KOI47_RS29825	COG0725	ABC transporter, periplasmic molybdate-binding protein
KOI47_RS29835	COG1846	Transcriptional regulator
KOI47_RS29840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KOI47_RS29855	COG1388	LysM domain
KOI47_RS29875	COG0427	acetyl-CoA hydrolase
KOI47_RS29880	COG2301	Belongs to the HpcH HpaI aldolase family
KOI47_RS29890	COG0583	DNA-binding transcription factor activity
KOI47_RS29900	COG1396	sequence-specific DNA binding
KOI47_RS29930	COG2018	Roadblock/LC7 domain
KOI47_RS29945	COG2018	Roadblock/LC7 domain
KOI47_RS29955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KOI47_RS29960	COG1174	glycine betaine transport
KOI47_RS29965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KOI47_RS29970	COG1116	anion transmembrane transporter activity
KOI47_RS29980	COG3142	Participates in the control of copper homeostasis
KOI47_RS29995	COG1061	Type III restriction enzyme res subunit
KOI47_RS30025	COG0693	protein deglycase activity
KOI47_RS30040	COG0459	protein refolding
KOI47_RS30050	COG1278	Cold shock
KOI47_RS30075	COG0688	phosphatidylethanolamine metabolic process
KOI47_RS30085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KOI47_RS30100	COG0242	peptide deformylase activity
KOI47_RS30110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KOI47_RS30115	COG0351	phosphomethylpyrimidine kinase
KOI47_RS30140	COG2022	thiamine diphosphate biosynthetic process
KOI47_RS30150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KOI47_RS30150	COG2022	thiamine diphosphate biosynthetic process
KOI47_RS30155	COG0352	thiamine-phosphate diphosphorylase activity
KOI47_RS30170	COG2188	Transcriptional regulator
KOI47_RS30175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KOI47_RS30180	COG2971	BadF BadG BcrA BcrD
KOI47_RS30190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KOI47_RS30205	COG3629	intracellular signal transduction
KOI47_RS30205	COG3903	Transcriptional regulator
KOI47_RS30210	COG5285	phytanoyl-CoA dioxygenase
KOI47_RS30215	COG1917	Cupin 2, conserved barrel domain protein
KOI47_RS30220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KOI47_RS30225	COG0456	acetyltransferase
KOI47_RS30250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KOI47_RS30255	COG0590	tRNA wobble adenosine to inosine editing
KOI47_RS30260	COG4399	Belongs to the UPF0754 family
KOI47_RS30265	COG0596	Alpha beta hydrolase
KOI47_RS30315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KOI47_RS30320	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS30325	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS30330	COG0395	ABC-type sugar transport system, permease component
KOI47_RS30345	COG1063	alcohol dehydrogenase
KOI47_RS30350	COG2390	Transcriptional regulator
KOI47_RS30365	COG2271	Major facilitator Superfamily
KOI47_RS30370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KOI47_RS30390	COG1079	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS30400	COG3845	ABC transporter
KOI47_RS30405	COG1744	ABC transporter substrate-binding protein PnrA-like
KOI47_RS30410	COG2009	succinate dehydrogenase
KOI47_RS30450	COG1404	Belongs to the peptidase S8 family
KOI47_RS30460	COG1686	Belongs to the peptidase S11 family
KOI47_RS30470	COG1295	ribonuclease BN
KOI47_RS30480	COG0180	Tryptophanyl-tRNA synthetase
KOI47_RS30495	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KOI47_RS30515	COG0708	Exodeoxyribonuclease III
KOI47_RS30520	COG1234	tRNA 3'-trailer cleavage
KOI47_RS30540	COG0367	asparagine synthase
KOI47_RS30550	COG2814	Major facilitator Superfamily
KOI47_RS30560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KOI47_RS30575	COG0587	DNA-directed DNA polymerase activity
KOI47_RS30595	COG0138	bifunctional purine biosynthesis protein purh
KOI47_RS30620	COG0045	succinate-CoA ligase (ADP-forming) activity
KOI47_RS30635	COG0739	heme binding
KOI47_RS30635	COG0741	lytic transglycosylase activity
KOI47_RS30635	COG1196	nuclear chromosome segregation
KOI47_RS30670	COG0515	serine threonine protein kinase
KOI47_RS30675	COG0515	serine threonine protein kinase
KOI47_RS30675	COG2815	serine threonine protein kinase
KOI47_RS30680	COG0583	DNA-binding transcription factor activity
KOI47_RS30685	COG0697	spore germination
KOI47_RS30725	COG0519	Catalyzes the synthesis of GMP from XMP
KOI47_RS30725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KOI47_RS30730	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS30740	COG0516	GMP reductase activity
KOI47_RS30785	COG1309	transcriptional regulator
KOI47_RS30790	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS30795	COG0459	protein refolding
KOI47_RS30800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KOI47_RS30810	COG3540	Alkaline phosphatase
KOI47_RS30820	COG0789	Transcriptional regulator
KOI47_RS30820	COG4978	Transcriptional regulator
KOI47_RS30825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KOI47_RS30830	COG1215	transferase activity, transferring glycosyl groups
KOI47_RS30850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KOI47_RS30855	COG0456	acetyltransferase
KOI47_RS30865	COG0802	atpase or kinase
KOI47_RS30875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KOI47_RS30880	COG1070	Carbohydrate kinase
KOI47_RS30885	COG1349	DNA-binding transcription factor activity
KOI47_RS30890	COG1063	alcohol dehydrogenase
KOI47_RS30900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KOI47_RS30930	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS30950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KOI47_RS30955	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KOI47_RS30960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KOI47_RS30975	COG4842	Belongs to the WXG100 family
KOI47_RS30985	COG0443	Heat shock 70 kDa protein
KOI47_RS30990	COG1674	ftsk spoiiie
KOI47_RS31000	COG1404	Belongs to the peptidase S8 family
KOI47_RS31025	COG0101	tRNA pseudouridine synthase activity
KOI47_RS31030	COG0203	ribosomal protein L17
KOI47_RS31035	COG0202	RNA polymerase activity
KOI47_RS31040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KOI47_RS31045	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KOI47_RS31060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KOI47_RS31065	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KOI47_RS31075	COG0563	adenylate kinase activity
KOI47_RS31100	COG1841	ribosomal large subunit assembly
KOI47_RS31105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KOI47_RS31110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KOI47_RS31115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KOI47_RS31120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KOI47_RS31125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KOI47_RS31130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KOI47_RS31140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KOI47_RS31145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KOI47_RS31150	COG0255	Belongs to the universal ribosomal protein uL29 family
KOI47_RS31160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KOI47_RS31165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KOI47_RS31170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KOI47_RS31175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KOI47_RS31180	COG0089	rRNA binding
KOI47_RS31185	COG0088	Forms part of the polypeptide exit tunnel
KOI47_RS31190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KOI47_RS31195	COG0051	transcription antitermination factor activity, RNA binding
KOI47_RS31205	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KOI47_RS31210	COG0049	tRNA binding
KOI47_RS31215	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KOI47_RS31245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KOI47_RS31270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KOI47_RS31295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KOI47_RS31315	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KOI47_RS31325	COG0081	regulation of translation
KOI47_RS31330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KOI47_RS31350	COG0436	Aminotransferase
KOI47_RS31365	COG2030	dehydratase
KOI47_RS31375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KOI47_RS31395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KOI47_RS31405	COG0586	Pfam SNARE associated Golgi protein
KOI47_RS31410	COG4585	Histidine kinase
KOI47_RS31415	COG2197	response regulator
KOI47_RS31530	COG1666	GTP binding
KOI47_RS31555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KOI47_RS31565	COG2814	Major facilitator Superfamily
KOI47_RS31570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KOI47_RS31575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KOI47_RS31580	COG1121	(ABC) transporter
KOI47_RS31585	COG0803	Belongs to the bacterial solute-binding protein 9 family
KOI47_RS31590	COG1834	amidinotransferase
KOI47_RS31595	COG1522	sequence-specific DNA binding
KOI47_RS31605	COG0674	pyruvate-flavodoxin oxidoreductase activity
KOI47_RS31605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KOI47_RS31610	COG1013	pyruvate-flavodoxin oxidoreductase activity
KOI47_RS31620	COG0142	geranyltranstransferase activity
KOI47_RS31670	COG1007	ATP synthesis coupled electron transport
KOI47_RS31685	COG0713	ATP synthesis coupled electron transport
KOI47_RS31695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOI47_RS31700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KOI47_RS31705	COG1034	ATP synthesis coupled electron transport
KOI47_RS31720	COG0649	NAD binding
KOI47_RS31725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOI47_RS31730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KOI47_RS31750	COG0438	transferase activity, transferring glycosyl groups
KOI47_RS31775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KOI47_RS31805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KOI47_RS31815	COG1522	sequence-specific DNA binding
KOI47_RS31835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KOI47_RS31855	COG0406	alpha-ribazole phosphatase activity
KOI47_RS31860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KOI47_RS31885	COG1648	precorrin-2 dehydrogenase activity
KOI47_RS31885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KOI47_RS31890	COG0181	hydroxymethylbilane synthase activity
KOI47_RS31895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KOI47_RS31900	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KOI47_RS31920	COG1595	DNA-templated transcription, initiation
KOI47_RS31955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KOI47_RS31965	COG0506	proline dehydrogenase activity
KOI47_RS31990	COG5002	protein histidine kinase activity
KOI47_RS32000	COG0667	Aldo Keto reductase
KOI47_RS32010	COG0588	phosphoglycerate mutase activity
KOI47_RS32025	COG0438	transferase activity, transferring glycosyl groups
KOI47_RS32030	COG2267	carboxylic ester hydrolase activity
KOI47_RS32045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KOI47_RS32085	COG0788	formyltetrahydrofolate deformylase activity
KOI47_RS32100	COG2130	NADP-dependent
KOI47_RS32145	COG0006	proline dipeptidase activity
KOI47_RS32165	COG2733	membrane
KOI47_RS32180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KOI47_RS32185	COG2364	Membrane
KOI47_RS32225	COG1120	ATPase activity
KOI47_RS32230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS32235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS32245	COG2197	response regulator
KOI47_RS32275	COG0589	response to stress
KOI47_RS32280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KOI47_RS32285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KOI47_RS32295	COG3706	GGDEF domain
KOI47_RS32335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KOI47_RS32340	COG2402	Toxic component of a toxin-antitoxin (TA) module. An RNase
KOI47_RS32380	COG1278	Cold shock
KOI47_RS32395	COG1408	metallophosphoesterase
KOI47_RS32405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOI47_RS32415	COG2197	response regulator
KOI47_RS32420	COG3851	Histidine kinase
KOI47_RS32440	COG1132	(ABC) transporter
KOI47_RS32445	COG1132	(ABC) transporter
KOI47_RS32455	COG0515	serine threonine protein kinase
KOI47_RS32495	COG1012	belongs to the aldehyde dehydrogenase family
KOI47_RS32500	COG0506	proline dehydrogenase activity
KOI47_RS32510	COG1024	Enoyl-CoA hydratase
KOI47_RS32520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS32545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KOI47_RS32550	COG0659	secondary active sulfate transmembrane transporter activity
KOI47_RS32560	COG2271	Major facilitator Superfamily
KOI47_RS32565	COG3973	AAA domain
KOI47_RS32580	COG0367	asparagine synthase
KOI47_RS32585	COG2826	transposase and inactivated derivatives, IS30 family
KOI47_RS32595	COG3170	Tfp pilus assembly protein FimV
KOI47_RS32600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KOI47_RS32610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KOI47_RS32615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KOI47_RS32635	COG2124	cytochrome p450
KOI47_RS32665	COG2801	Transposase and inactivated derivatives
KOI47_RS32685	COG3903	Transcriptional regulator
KOI47_RS32685	COG3629	intracellular signal transduction
KOI47_RS32690	COG0076	glutamate decarboxylase activity
KOI47_RS32705	COG4865	methylaspartate mutase activity
KOI47_RS32710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KOI47_RS32755	COG3344	reverse transcriptase
KOI47_RS32765	COG0018	arginyl-trna synthetase
KOI47_RS32780	COG0017	Asparaginyl-tRNA synthetase
KOI47_RS32800	COG3344	reverse transcriptase
KOI47_RS32815	COG0189	ligase activity
KOI47_RS32820	COG1834	amidinotransferase
KOI47_RS32885	COG0546	phosphoglycolate phosphatase activity
KOI47_RS32915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS33030	COG0714	Associated with various cellular activities
KOI47_RS33165	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KOI47_RS33220	COG0464	growth
KOI47_RS33250	COG2186	Transcriptional regulator
KOI47_RS33260	COG0318	PFAM AMP-dependent synthetase and ligase
KOI47_RS33265	COG0825	malonyl-CoA metabolic process
KOI47_RS33265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KOI47_RS33270	COG4106	trans-aconitate 2-methyltransferase activity
KOI47_RS33280	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS33295	COG0395	ABC-type sugar transport system, permease component
KOI47_RS33320	COG5297	Belongs to the glycosyl hydrolase family 6
KOI47_RS33320	COG4733	cellulase activity
KOI47_RS33355	COG3851	Histidine kinase
KOI47_RS33360	COG2197	response regulator
KOI47_RS33380	COG2197	response regulator
KOI47_RS33385	COG4585	Histidine kinase
KOI47_RS33395	COG1131	(ABC) transporter
KOI47_RS33400	COG1476	TRANSCRIPTIONal
KOI47_RS33485	COG0704	Plays a role in the regulation of phosphate uptake
KOI47_RS33505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KOI47_RS33510	COG0456	acetyltransferase
KOI47_RS33510	COG0454	-acetyltransferase
KOI47_RS33515	COG0745	RESPONSE REGULATOR receiver
KOI47_RS33545	COG4044	May play a role in the intracellular transport of hydrophobic ligands
KOI47_RS33610	COG3290	protein histidine kinase activity
KOI47_RS33615	COG4565	transcriptional regulatory protein
KOI47_RS33635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KOI47_RS33640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KOI47_RS33695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KOI47_RS33700	COG1132	(ABC) transporter
KOI47_RS33705	COG1132	(ABC) transporter
KOI47_RS33710	COG0047	phosphoribosylformylglycinamidine synthase activity
KOI47_RS33715	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KOI47_RS33740	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KOI47_RS33755	COG0730	response to heat
KOI47_RS33765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KOI47_RS33810	COG0436	Aminotransferase
KOI47_RS33850	COG0584	glycerophosphoryl diester phosphodiesterase
KOI47_RS33855	COG2814	Major facilitator Superfamily
KOI47_RS33865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KOI47_RS33900	COG0300	oxidoreductase activity
KOI47_RS33915	COG1620	l-lactate permease
KOI47_RS33945	COG0277	FAD linked oxidase domain protein
KOI47_RS33950	COG0477	Major facilitator Superfamily
KOI47_RS33965	COG3467	pyridoxamine 5'-phosphate
KOI47_RS33970	COG3795	YCII-related domain
KOI47_RS33990	COG1396	sequence-specific DNA binding
KOI47_RS34015	COG2353	YceI-like domain
KOI47_RS34020	COG0586	Pfam SNARE associated Golgi protein
KOI47_RS34030	COG3629	intracellular signal transduction
KOI47_RS34030	COG3903	Transcriptional regulator
KOI47_RS34045	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS34055	COG1072	(Pantothenic acid kinase))
KOI47_RS34065	COG1609	Transcriptional regulator
KOI47_RS34075	COG0243	molybdopterin cofactor binding
KOI47_RS34080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KOI47_RS34095	COG4221	oxidoreductase activity
KOI47_RS34110	COG0542	response to heat
KOI47_RS34115	COG1115	amino acid carrier protein
KOI47_RS34205	COG0789	Transcriptional regulator
KOI47_RS34210	COG0484	heat shock protein binding
KOI47_RS34220	COG0443	Heat shock 70 kDa protein
KOI47_RS34250	COG2181	nitrate reductase activity
KOI47_RS34250	COG0247	lactate metabolic process
KOI47_RS34260	COG0745	RESPONSE REGULATOR receiver
KOI47_RS34265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KOI47_RS34340	COG1309	transcriptional regulator
KOI47_RS34345	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS34350	COG1024	Enoyl-CoA hydratase
KOI47_RS34355	COG1024	Enoyl-CoA hydratase
KOI47_RS34360	COG0706	membrane insertase activity
KOI47_RS34370	COG2340	Cysteine-rich secretory protein family
KOI47_RS34380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KOI47_RS34385	COG0717	Belongs to the dCTP deaminase family
KOI47_RS34415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KOI47_RS34415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KOI47_RS34440	COG0583	DNA-binding transcription factor activity
KOI47_RS34460	COG3663	DNA glycosylase
KOI47_RS34465	COG2197	response regulator
KOI47_RS34470	COG1960	acyl-CoA dehydrogenase activity
KOI47_RS34480	COG0640	Transcriptional regulator
KOI47_RS34505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KOI47_RS34530	COG1126	abc transporter atp-binding protein
KOI47_RS34535	COG0765	amino acid transport
KOI47_RS34540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KOI47_RS34555	COG1305	Transglutaminase-like
KOI47_RS34565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS34570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KOI47_RS34585	COG0410	ABC transporter
KOI47_RS34600	COG0559	Belongs to the binding-protein-dependent transport system permease family
KOI47_RS34615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KOI47_RS34625	COG0022	dehydrogenase e1 component
KOI47_RS34630	COG0508	dehydrogenase complex catalyzes the overall conversion of
KOI47_RS34635	COG3030	protein affecting phage T7 exclusion by the F plasmid
KOI47_RS34650	COG1309	transcriptional regulator
KOI47_RS34655	COG2030	dehydratase
KOI47_RS34660	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS34665	COG0183	Belongs to the thiolase family
KOI47_RS34685	COG0584	glycerophosphoryl diester phosphodiesterase
KOI47_RS34750	COG1595	DNA-templated transcription, initiation
KOI47_RS34765	COG1914	H( )-stimulated, divalent metal cation uptake system
KOI47_RS34775	COG1131	(ABC) transporter
KOI47_RS34785	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KOI47_RS34805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KOI47_RS34815	COG4585	Histidine kinase
KOI47_RS34820	COG2197	response regulator
KOI47_RS34830	COG0346	lactoylglutathione lyase activity
KOI47_RS34855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KOI47_RS34870	COG1136	(ABC) transporter
KOI47_RS34880	COG2197	response regulator
KOI47_RS34885	COG0402	S-adenosylhomocysteine deaminase activity
KOI47_RS34890	COG1902	pentaerythritol trinitrate reductase activity
KOI47_RS34900	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS34910	COG2814	Major facilitator Superfamily
KOI47_RS34915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KOI47_RS34950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KOI47_RS34975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KOI47_RS34995	COG0360	Binds together with S18 to 16S ribosomal RNA
KOI47_RS35000	COG0629	single-stranded DNA binding
KOI47_RS35005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KOI47_RS35010	COG0359	binds to the 23S rRNA
KOI47_RS35035	COG0305	Participates in initiation and elongation during chromosome replication
KOI47_RS35045	COG1028	Short-chain dehydrogenase reductase Sdr
KOI47_RS35060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KOI47_RS35105	COG2197	response regulator
KOI47_RS35120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KOI47_RS35125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KOI47_RS35145	COG0495	leucyl-tRNA aminoacylation
KOI47_RS35170	COG1678	Uncharacterized ACR, COG1678
KOI47_RS35185	COG4585	Histidine kinase
KOI47_RS35190	COG2197	response regulator
KOI47_RS35200	COG1136	(ABC) transporter
KOI47_RS35215	COG0617	tRNA 3'-terminal CCA addition
KOI47_RS35240	COG1595	DNA-templated transcription, initiation
KOI47_RS35255	COG3118	belongs to the thioredoxin family
KOI47_RS35255	COG0492	ferredoxin-NADP+ reductase activity
KOI47_RS35260	COG0860	N-Acetylmuramoyl-L-alanine amidase
KOI47_RS35260	COG3409	Peptidoglycan-binding domain 1 protein
KOI47_RS35285	COG1181	Belongs to the D-alanine--D-alanine ligase family
KOI47_RS35295	COG1192	Involved in chromosome partitioning
KOI47_RS35300	COG0357	Ribosomal RNA small subunit methyltransferase G
KOI47_RS35320	COG0594	ribonuclease P activity
KOI47_RS35355	COG3757	hydrolase, family 25
KOI47_RS35355	COG3409	Peptidoglycan-binding domain 1 protein
KOI47_RS35440	COG1104	cysteine desulfurase activity
KOI47_RS35570	COG5297	Belongs to the glycosyl hydrolase family 6
KOI47_RS35580	COG3321	synthase
KOI47_RS35580	COG0604	alcohol dehydrogenase
KOI47_RS35605	COG3321	synthase
KOI47_RS35605	COG0604	alcohol dehydrogenase
KOI47_RS35610	COG0604	alcohol dehydrogenase
KOI47_RS35610	COG3321	synthase
KOI47_RS35645	COG1132	(ABC) transporter
KOI47_RS35690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KOI47_RS35865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KOI47_RS36170	COG1957	nucleoside hydrolase
KOI47_RS36200	COG3629	intracellular signal transduction
KOI47_RS36200	COG3903	Transcriptional regulator
KOI47_RS36205	COG4585	Histidine kinase