locus-tag	class	description
A4R43_RS00015	COG2080	2 iron, 2 sulfur cluster binding
A4R43_RS00055	COG1414	Transcriptional regulator
A4R43_RS00085	COG2124	cytochrome p450
A4R43_RS00095	COG5001	Diguanylate cyclase
A4R43_RS00100	COG1309	transcriptional regulator
A4R43_RS00110	COG0740	serine-type endopeptidase activity
A4R43_RS00115	COG0456	acetyltransferase
A4R43_RS00160	COG4941	Belongs to the sigma-70 factor family
A4R43_RS00165	COG1959	2 iron, 2 sulfur cluster binding
A4R43_RS00185	COG0395	ABC-type sugar transport system, permease component
A4R43_RS00220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS00230	COG2079	MmgE PrpD family protein
A4R43_RS00240	COG2301	Belongs to the HpcH HpaI aldolase family
A4R43_RS00245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS00290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_RS00310	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS00315	COG1024	Enoyl-CoA hydratase
A4R43_RS00325	COG1024	Enoyl-CoA hydratase
A4R43_RS00330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4R43_RS00340	COG2271	Major facilitator Superfamily
A4R43_RS00345	COG0745	RESPONSE REGULATOR receiver
A4R43_RS00350	COG2205	protein histidine kinase activity
A4R43_RS00425	COG1802	Transcriptional regulator
A4R43_RS00435	COG2376	Dihydroxyacetone kinase
A4R43_RS00440	COG0698	ribose 5-phosphate isomerase
A4R43_RS00445	COG0149	triose-phosphate isomerase activity
A4R43_RS00465	COG0583	DNA-binding transcription factor activity
A4R43_RS00525	COG1132	(ABC) transporter
A4R43_RS00530	COG1132	(ABC) transporter
A4R43_RS00530	COG2375	cellular response to nickel ion
A4R43_RS00565	COG2205	protein histidine kinase activity
A4R43_RS00570	COG0745	RESPONSE REGULATOR receiver
A4R43_RS00575	COG1113	amino acid transport
A4R43_RS00585	COG1695	Transcriptional regulator
A4R43_RS00605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4R43_RS00620	COG0025	NhaP-type Na H and K H
A4R43_RS00630	COG1595	DNA-templated transcription, initiation
A4R43_RS00635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_RS00650	COG0789	Transcriptional regulator
A4R43_RS00655	COG2084	Dehydrogenase
A4R43_RS00685	COG0604	alcohol dehydrogenase
A4R43_RS00685	COG3321	synthase
A4R43_RS00715	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A4R43_RS00785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS00830	COG2318	DinB family
A4R43_RS00860	COG2197	response regulator
A4R43_RS00870	COG2172	sigma factor antagonist activity
A4R43_RS00870	COG1366	Belongs to the anti-sigma-factor antagonist family
A4R43_RS00870	COG2208	phosphoserine phosphatase activity
A4R43_RS00880	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A4R43_RS00890	COG1737	Transcriptional regulator
A4R43_RS00890	COG0837	glucose binding
A4R43_RS00925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R43_RS00935	COG4977	sequence-specific DNA binding
A4R43_RS00985	COG0789	Transcriptional regulator
A4R43_RS00985	COG4978	Transcriptional regulator
A4R43_RS00990	COG0583	DNA-binding transcription factor activity
A4R43_RS01035	COG5377	YqaJ viral recombinase family
A4R43_RS01040	COG3723	Recombinational DNA repair protein, rece pathway
A4R43_RS01300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_RS01320	COG3599	regulation of cell shape
A4R43_RS01345	COG2010	Cytochrome c
A4R43_RS01345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_RS01350	COG2080	2 iron, 2 sulfur cluster binding
A4R43_RS01380	COG2207	Transcriptional regulator
A4R43_RS01385	COG2223	nitrite transmembrane transporter activity
A4R43_RS01395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4R43_RS01395	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4R43_RS01485	COG1309	transcriptional regulator
A4R43_RS01505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_RS01525	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_RS01535	COG0659	secondary active sulfate transmembrane transporter activity
A4R43_RS01540	COG0288	reversible hydration of carbon dioxide
A4R43_RS01555	COG1278	Cold shock
A4R43_RS01570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS01580	COG1733	regulation of RNA biosynthetic process
A4R43_RS01600	COG0640	Transcriptional regulator
A4R43_RS01630	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS01655	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS01670	COG2814	Major facilitator Superfamily
A4R43_RS01690	COG0640	Transcriptional regulator
A4R43_RS01710	COG1309	transcriptional regulator
A4R43_RS01725	COG2315	Protein conserved in bacteria
A4R43_RS01735	COG0640	Transcriptional regulator
A4R43_RS01750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4R43_RS01765	COG2226	methyltransferase
A4R43_RS01795	COG1802	Transcriptional regulator
A4R43_RS01800	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS01825	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A4R43_RS01845	COG1595	DNA-templated transcription, initiation
A4R43_RS01850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_RS01865	COG1733	regulation of RNA biosynthetic process
A4R43_RS01890	COG0640	Transcriptional regulator
A4R43_RS01900	COG0569	domain protein
A4R43_RS01905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4R43_RS01925	COG3848	Pyruvate phosphate dikinase
A4R43_RS01925	COG0574	Belongs to the PEP-utilizing enzyme family
A4R43_RS02045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4R43_RS02070	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_RS02080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4R43_RS02085	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4R43_RS02090	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_RS02095	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS02105	COG2851	Citrate transporter
A4R43_RS02125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4R43_RS02130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4R43_RS02135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4R43_RS02140	COG1414	Transcriptional regulator
A4R43_RS02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS02190	COG2188	Transcriptional regulator
A4R43_RS02215	COG3251	PFAM MbtH domain protein
A4R43_RS02220	COG1132	(ABC) transporter
A4R43_RS02225	COG1132	(ABC) transporter
A4R43_RS02360	COG0475	glutathione-regulated potassium exporter activity
A4R43_RS02415	COG0246	Mannitol dehydrogenase
A4R43_RS02420	COG0477	Major facilitator Superfamily
A4R43_RS02425	COG1063	alcohol dehydrogenase
A4R43_RS02435	COG1522	sequence-specific DNA binding
A4R43_RS02445	COG0667	Aldo Keto reductase
A4R43_RS02450	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A4R43_RS02475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4R43_RS02490	COG0494	nUDIX hydrolase
A4R43_RS02495	COG1011	Hydrolase
A4R43_RS02515	COG0494	nUDIX hydrolase
A4R43_RS02555	COG0395	ABC-type sugar transport system, permease component
A4R43_RS02575	COG1522	sequence-specific DNA binding
A4R43_RS02610	COG2815	serine threonine protein kinase
A4R43_RS02610	COG0515	serine threonine protein kinase
A4R43_RS02625	COG0443	Heat shock 70 kDa protein
A4R43_RS02645	COG2205	protein histidine kinase activity
A4R43_RS02650	COG0745	RESPONSE REGULATOR receiver
A4R43_RS02655	COG2259	Doxx family
A4R43_RS02675	COG1309	transcriptional regulator
A4R43_RS02680	COG2080	2 iron, 2 sulfur cluster binding
A4R43_RS02685	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R43_RS02690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_RS02695	COG0673	inositol 2-dehydrogenase activity
A4R43_RS02710	COG0463	Glycosyl transferase, family 2
A4R43_RS02725	COG0596	Alpha beta hydrolase
A4R43_RS02740	COG1115	amino acid carrier protein
A4R43_RS02745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4R43_RS02750	COG1819	glycosyl
A4R43_RS02770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS02835	COG1063	alcohol dehydrogenase
A4R43_RS02840	COG0477	Major facilitator Superfamily
A4R43_RS02850	COG4106	trans-aconitate 2-methyltransferase activity
A4R43_RS02930	COG1937	Protein conserved in bacteria
A4R43_RS02980	COG1073	alpha beta
A4R43_RS02990	COG0798	PFAM Bile acid sodium symporter
A4R43_RS03000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4R43_RS03010	COG2072	flavoprotein involved in K transport
A4R43_RS03020	COG0640	Transcriptional regulator
A4R43_RS03025	COG0583	DNA-binding transcription factor activity
A4R43_RS03035	COG3485	protocatechuate 3,4-dioxygenase
A4R43_RS03040	COG4829	muconolactone delta-isomerase
A4R43_RS03045	COG4829	muconolactone delta-isomerase
A4R43_RS03050	COG4829	muconolactone delta-isomerase
A4R43_RS03065	COG0477	Major facilitator Superfamily
A4R43_RS03085	COG2807	transmembrane transport
A4R43_RS03090	COG0583	DNA-binding transcription factor activity
A4R43_RS03115	COG0583	DNA-binding transcription factor activity
A4R43_RS03120	COG2070	2-Nitropropane dioxygenase
A4R43_RS03125	COG4221	oxidoreductase activity
A4R43_RS03170	COG2172	sigma factor antagonist activity
A4R43_RS03175	COG1366	Belongs to the anti-sigma-factor antagonist family
A4R43_RS03180	COG1366	Belongs to the anti-sigma-factor antagonist family
A4R43_RS03210	COG0477	Major facilitator Superfamily
A4R43_RS03235	COG1309	transcriptional regulator
A4R43_RS03255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS03330	COG1595	DNA-templated transcription, initiation
A4R43_RS03345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4R43_RS03375	COG2814	Major facilitator Superfamily
A4R43_RS03395	COG1595	DNA-templated transcription, initiation
A4R43_RS03410	COG0583	DNA-binding transcription factor activity
A4R43_RS03415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_RS03440	COG2124	cytochrome p450
A4R43_RS03470	COG3629	intracellular signal transduction
A4R43_RS03470	COG3903	Transcriptional regulator
A4R43_RS03480	COG0300	oxidoreductase activity
A4R43_RS03485	COG0583	DNA-binding transcription factor activity
A4R43_RS03490	COG2226	methyltransferase
A4R43_RS03495	COG0477	Major facilitator Superfamily
A4R43_RS03510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS03520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4R43_RS03525	COG0277	FAD linked oxidase domain protein
A4R43_RS03525	COG0247	lactate metabolic process
A4R43_RS03530	COG3622	Belongs to the hyi family
A4R43_RS03535	COG2084	Dehydrogenase
A4R43_RS03540	COG3960	tartronate-semialdehyde synthase activity
A4R43_RS03600	COG0583	DNA-binding transcription factor activity
A4R43_RS03605	COG0667	Aldo Keto reductase
A4R43_RS03615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4R43_RS03620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS03655	COG1846	Transcriptional regulator
A4R43_RS03660	COG0697	spore germination
A4R43_RS03670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4R43_RS03675	COG0747	negative chemotaxis
A4R43_RS03685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R43_RS03690	COG0444	Belongs to the ABC transporter superfamily
A4R43_RS03695	COG4608	Belongs to the ABC transporter superfamily
A4R43_RS03705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4R43_RS03710	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS03715	COG1414	Transcriptional regulator
A4R43_RS03725	COG1309	transcriptional regulator
A4R43_RS03735	COG1024	Enoyl-CoA hydratase
A4R43_RS03740	COG3903	Transcriptional regulator
A4R43_RS03740	COG3629	intracellular signal transduction
A4R43_RS03755	COG4585	Histidine kinase
A4R43_RS03755	COG2203	Gaf domain
A4R43_RS03775	COG3903	Transcriptional regulator
A4R43_RS03775	COG3629	intracellular signal transduction
A4R43_RS03780	COG0488	(ABC) transporter
A4R43_RS03795	COG0247	lactate metabolic process
A4R43_RS03800	COG0277	FAD linked oxidase domain protein
A4R43_RS03815	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS03825	COG1063	alcohol dehydrogenase
A4R43_RS03830	COG2188	Transcriptional regulator
A4R43_RS03835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R43_RS03840	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A4R43_RS03850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R43_RS03855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_RS03860	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R43_RS03865	COG2080	2 iron, 2 sulfur cluster binding
A4R43_RS03870	COG1309	transcriptional regulator
A4R43_RS03890	COG2814	Major facilitator Superfamily
A4R43_RS03895	COG3940	Belongs to the glycosyl hydrolase 43 family
A4R43_RS03905	COG3250	beta-galactosidase activity
A4R43_RS03910	COG3540	Alkaline phosphatase
A4R43_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS03960	COG2197	response regulator
A4R43_RS03970	COG0577	efflux transmembrane transporter activity
A4R43_RS03970	COG1136	(ABC) transporter
A4R43_RS03975	COG0577	efflux transmembrane transporter activity
A4R43_RS03990	COG0302	gtp cyclohydrolase
A4R43_RS04000	COG1120	ATPase activity
A4R43_RS04005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4R43_RS04030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_RS04090	COG1914	H( )-stimulated, divalent metal cation uptake system
A4R43_RS04095	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS04100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4R43_RS04115	COG0667	Aldo Keto reductase
A4R43_RS04120	COG4608	Belongs to the ABC transporter superfamily
A4R43_RS04125	COG0444	Belongs to the ABC transporter superfamily
A4R43_RS04130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R43_RS04135	COG0601	transmembrane transport
A4R43_RS04150	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4R43_RS04155	COG1349	DNA-binding transcription factor activity
A4R43_RS04170	COG2746	aminoglycoside 3-N-acetyltransferase activity
A4R43_RS04175	COG1120	ATPase activity
A4R43_RS04200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_RS04230	COG0778	Nitroreductase
A4R43_RS04235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4R43_RS04265	COG1560	Kdo2-lipid A biosynthetic process
A4R43_RS04270	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS04285	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A4R43_RS04315	COG3629	intracellular signal transduction
A4R43_RS04315	COG3903	Transcriptional regulator
A4R43_RS04325	COG2197	response regulator
A4R43_RS04335	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A4R43_RS04350	COG3629	intracellular signal transduction
A4R43_RS04350	COG3903	Transcriptional regulator
A4R43_RS04355	COG0640	Transcriptional regulator
A4R43_RS04385	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A4R43_RS04390	COG0217	transcriptional regulatory protein
A4R43_RS04400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A4R43_RS04405	COG0632	four-way junction helicase activity
A4R43_RS04410	COG2255	four-way junction helicase activity
A4R43_RS04425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4R43_RS04430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4R43_RS04435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4R43_RS04440	COG1024	Enoyl-CoA hydratase
A4R43_RS04445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4R43_RS04465	COG1414	Transcriptional regulator
A4R43_RS04490	COG0673	inositol 2-dehydrogenase activity
A4R43_RS04505	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS04540	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4R43_RS04570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4R43_RS04585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4R43_RS04605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4R43_RS04615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4R43_RS04620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4R43_RS04625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A4R43_RS04645	COG0275	rRNA processing
A4R43_RS04650	COG2124	cytochrome p450
A4R43_RS04670	COG2124	cytochrome p450
A4R43_RS04680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_RS04685	COG1263	PTS System
A4R43_RS04690	COG2188	Transcriptional regulator
A4R43_RS04695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4R43_RS04730	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4R43_RS04735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4R43_RS04740	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4R43_RS04745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4R43_RS04750	COG0346	lactoylglutathione lyase activity
A4R43_RS04765	COG0006	proline dipeptidase activity
A4R43_RS04770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4R43_RS04775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4R43_RS04790	COG0540	Belongs to the ATCase OTCase family
A4R43_RS04805	COG0505	Belongs to the CarA family
A4R43_RS04815	COG0284	orotidine-5'-phosphate decarboxylase activity
A4R43_RS04830	COG1758	RNA polymerase activity
A4R43_RS04840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4R43_RS04845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4R43_RS04855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_RS04860	COG0405	Gamma-glutamyltransferase
A4R43_RS04865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4R43_RS04895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_RS04895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_RS04920	COG0322	excinuclease ABC activity
A4R43_RS04925	COG1660	Displays ATPase and GTPase activities
A4R43_RS04930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4R43_RS04935	COG1481	regulation of sporulation
A4R43_RS04990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4R43_RS04995	COG0126	phosphoglycerate kinase activity
A4R43_RS05000	COG0149	triose-phosphate isomerase activity
A4R43_RS05015	COG3850	Histidine kinase
A4R43_RS05020	COG0363	glucosamine-6-phosphate deaminase activity
A4R43_RS05035	COG0166	Belongs to the GPI family
A4R43_RS05040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4R43_RS05050	COG0109	protoheme IX farnesyltransferase activity
A4R43_RS05060	COG1733	regulation of RNA biosynthetic process
A4R43_RS05065	COG3973	AAA domain
A4R43_RS05070	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4R43_RS05080	COG0604	alcohol dehydrogenase
A4R43_RS05130	COG0396	ATPase activity
A4R43_RS05140	COG0822	iron-sulfur transferase activity
A4R43_RS05150	COG0504	CTP synthase activity
A4R43_RS05160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4R43_RS05165	COG4585	Histidine kinase
A4R43_RS05170	COG2197	response regulator
A4R43_RS05175	COG5002	protein histidine kinase activity
A4R43_RS05175	COG5001	Diguanylate cyclase
A4R43_RS05175	COG3447	MASE1 domain protein
A4R43_RS05195	COG0488	(ABC) transporter
A4R43_RS05210	COG1132	(ABC) transporter
A4R43_RS05225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_RS05230	COG1316	TRANSCRIPTIONal
A4R43_RS05240	COG5001	Diguanylate cyclase
A4R43_RS05240	COG3300	MHYT domain
A4R43_RS05250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4R43_RS05255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_RS05260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4R43_RS05260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_RS05270	COG1024	Enoyl-CoA hydratase
A4R43_RS05290	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS05315	COG1309	transcriptional regulator
A4R43_RS05345	COG0596	Alpha beta hydrolase
A4R43_RS05355	COG1309	transcriptional regulator
A4R43_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS05365	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS05370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_RS05380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R43_RS05385	COG1024	Enoyl-CoA hydratase
A4R43_RS05400	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_RS05405	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS05410	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS05440	COG2186	Transcriptional regulator
A4R43_RS05445	COG2197	response regulator
A4R43_RS05450	COG3903	Transcriptional regulator
A4R43_RS05450	COG3629	intracellular signal transduction
A4R43_RS05495	COG1793	dna ligase
A4R43_RS05495	COG3285	dna ligase
A4R43_RS05510	COG2197	response regulator
A4R43_RS05550	COG0542	response to heat
A4R43_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS05595	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_RS05600	COG1070	Carbohydrate kinase
A4R43_RS05605	COG3347	Dehydrogenase
A4R43_RS05605	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS05610	COG1609	Transcriptional regulator
A4R43_RS05650	COG4335	DNA alkylation repair
A4R43_RS05660	COG1309	transcriptional regulator
A4R43_RS05700	COG2124	cytochrome p450
A4R43_RS05710	COG0009	L-threonylcarbamoyladenylate synthase
A4R43_RS05725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_RS05735	COG0477	Major facilitator Superfamily
A4R43_RS05745	COG1131	(ABC) transporter
A4R43_RS05755	COG2197	response regulator
A4R43_RS05790	COG2271	Major facilitator Superfamily
A4R43_RS05795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_RS05835	COG0045	succinate-CoA ligase (ADP-forming) activity
A4R43_RS05845	COG2084	Dehydrogenase
A4R43_RS05855	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4R43_RS05860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4R43_RS05875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS05905	COG1802	Transcriptional regulator
A4R43_RS05915	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS05930	COG3383	formate dehydrogenase (NAD+) activity
A4R43_RS05970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_RS05975	COG0028	Belongs to the TPP enzyme family
A4R43_RS05980	COG1414	Transcriptional regulator
A4R43_RS06000	COG0435	Glutathione S-transferase
A4R43_RS06025	COG0657	acetylesterase activity
A4R43_RS06030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS06035	COG0277	FAD linked oxidase domain protein
A4R43_RS06045	COG2124	cytochrome p450
A4R43_RS06065	COG1929	Belongs to the glycerate kinase type-1 family
A4R43_RS06070	COG3960	tartronate-semialdehyde synthase activity
A4R43_RS06075	COG2084	Dehydrogenase
A4R43_RS06080	COG3622	Belongs to the hyi family
A4R43_RS06090	COG2252	PERMEase
A4R43_RS06095	COG0590	tRNA wobble adenosine to inosine editing
A4R43_RS06100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_RS06120	COG3835	regulator
A4R43_RS06140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A4R43_RS06160	COG0028	Belongs to the TPP enzyme family
A4R43_RS06165	COG0583	DNA-binding transcription factor activity
A4R43_RS06175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4R43_RS06180	COG1053	succinate dehydrogenase
A4R43_RS06190	COG0583	DNA-binding transcription factor activity
A4R43_RS06195	COG2040	homocysteine
A4R43_RS06215	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS06250	COG1846	Transcriptional regulator
A4R43_RS06285	COG2814	Major facilitator Superfamily
A4R43_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS06310	COG2936	dipeptidyl-peptidase activity
A4R43_RS06315	COG0723	plastoquinol--plastocyanin reductase activity
A4R43_RS06340	COG0248	Ppx GppA phosphatase
A4R43_RS06360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_RS06365	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4R43_RS06370	COG2080	2 iron, 2 sulfur cluster binding
A4R43_RS06375	COG0693	protein deglycase activity
A4R43_RS06390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4R43_RS06390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4R43_RS06425	COG4209	transmembrane transport
A4R43_RS06430	COG0395	ABC-type sugar transport system, permease component
A4R43_RS06440	COG3415	Transposase
A4R43_RS06440	COG2801	Transposase and inactivated derivatives
A4R43_RS06465	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_RS06470	COG1609	Transcriptional regulator
A4R43_RS06480	COG1175	transmembrane transport
A4R43_RS06485	COG0395	ABC-type sugar transport system, permease component
A4R43_RS06500	COG4733	cellulase activity
A4R43_RS06500	COG5297	Belongs to the glycosyl hydrolase family 6
A4R43_RS06525	COG3842	ATPase activity
A4R43_RS06530	COG2723	6-phospho-beta-galactosidase activity
A4R43_RS06535	COG0395	ABC-type sugar transport system, permease component
A4R43_RS06560	COG5297	Belongs to the glycosyl hydrolase family 6
A4R43_RS06570	COG1335	isochorismatase
A4R43_RS06620	COG1595	DNA-templated transcription, initiation
A4R43_RS06670	COG3265	gluconokinase activity
A4R43_RS06690	COG0477	Major facilitator Superfamily
A4R43_RS06710	COG0477	Major facilitator Superfamily
A4R43_RS06720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4R43_RS06725	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A4R43_RS06725	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_RS06765	COG2124	cytochrome p450
A4R43_RS06790	COG5002	protein histidine kinase activity
A4R43_RS06800	COG1185	polyribonucleotide nucleotidyltransferase activity
A4R43_RS06845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_RS06855	COG0444	Belongs to the ABC transporter superfamily
A4R43_RS06865	COG0747	negative chemotaxis
A4R43_RS06870	COG2186	Transcriptional regulator
A4R43_RS06890	COG0583	DNA-binding transcription factor activity
A4R43_RS06910	COG1053	succinate dehydrogenase
A4R43_RS06910	COG3976	FMN-binding domain protein
A4R43_RS06910	COG0431	NADPH-dependent FMN reductase
A4R43_RS06915	COG1802	Transcriptional regulator
A4R43_RS06920	COG2356	endonuclease I
A4R43_RS06925	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4R43_RS06925	COG3291	Pkd domain containing protein
A4R43_RS06985	COG2814	Major facilitator Superfamily
A4R43_RS06995	COG1253	flavin adenine dinucleotide binding
A4R43_RS07000	COG1253	flavin adenine dinucleotide binding
A4R43_RS07070	COG1522	sequence-specific DNA binding
A4R43_RS07075	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A4R43_RS07090	COG1335	isochorismatase
A4R43_RS07105	COG1609	Transcriptional regulator
A4R43_RS07110	COG1175	transmembrane transport
A4R43_RS07135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_RS07150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS07160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_RS07180	COG3938	Belongs to the proline racemase family
A4R43_RS07190	COG1024	Enoyl-CoA hydratase
A4R43_RS07205	COG0667	Aldo Keto reductase
A4R43_RS07220	COG4585	Histidine kinase
A4R43_RS07225	COG2197	response regulator
A4R43_RS07240	COG0583	DNA-binding transcription factor activity
A4R43_RS07245	COG2814	Major facilitator Superfamily
A4R43_RS07255	COG0583	DNA-binding transcription factor activity
A4R43_RS07275	COG3401	FG-GAP repeat protein
A4R43_RS07340	COG4941	Belongs to the sigma-70 factor family
A4R43_RS07345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4R43_RS07370	COG2197	response regulator
A4R43_RS07380	COG1131	(ABC) transporter
A4R43_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS07450	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS07480	COG1486	melibiose metabolic process
A4R43_RS07485	COG1349	DNA-binding transcription factor activity
A4R43_RS07490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_RS07495	COG1653	transport
A4R43_RS07505	COG0395	ABC-type sugar transport system, permease component
A4R43_RS07520	COG0702	epimerase
A4R43_RS07535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_RS07560	COG1088	dTDP-glucose 4,6-dehydratase activity
A4R43_RS07575	COG1215	transferase activity, transferring glycosyl groups
A4R43_RS07585	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS07590	COG2192	nodulation
A4R43_RS07595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4R43_RS07600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4R43_RS07605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4R43_RS07605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4R43_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS07620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4R43_RS07630	COG0300	oxidoreductase activity
A4R43_RS07640	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4R43_RS07655	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R43_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS07685	COG3546	catalase activity
A4R43_RS07720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_RS07735	COG4585	Histidine kinase
A4R43_RS07740	COG2197	response regulator
A4R43_RS07745	COG0402	S-adenosylhomocysteine deaminase activity
A4R43_RS07750	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS07755	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A4R43_RS07775	COG1064	alcohol dehydrogenase
A4R43_RS07780	COG1309	transcriptional regulator
A4R43_RS07820	COG3209	COG3209 Rhs family protein
A4R43_RS07820	COG4104	PAAR repeat-containing protein
A4R43_RS07825	COG2318	DinB family
A4R43_RS07845	COG0583	DNA-binding transcription factor activity
A4R43_RS07850	COG0657	acetylesterase activity
A4R43_RS07880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4R43_RS07900	COG0640	Transcriptional regulator
A4R43_RS07905	COG0583	DNA-binding transcription factor activity
A4R43_RS07915	COG4638	Rieske (2fe-2S)
A4R43_RS07945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_RS07950	COG1024	Enoyl-CoA hydratase
A4R43_RS07960	COG0028	Belongs to the TPP enzyme family
A4R43_RS07975	COG1024	Enoyl-CoA hydratase
A4R43_RS07980	COG1024	Enoyl-CoA hydratase
A4R43_RS07990	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS08010	COG3321	synthase
A4R43_RS08010	COG0604	alcohol dehydrogenase
A4R43_RS08025	COG0604	alcohol dehydrogenase
A4R43_RS08025	COG3321	synthase
A4R43_RS08035	COG2226	methyltransferase
A4R43_RS08050	COG3693	PFAM glycoside hydrolase, family 10
A4R43_RS08060	COG0693	protein deglycase activity
A4R43_RS08090	COG0659	secondary active sulfate transmembrane transporter activity
A4R43_RS08115	COG2197	response regulator
A4R43_RS08125	COG3903	Transcriptional regulator
A4R43_RS08125	COG3629	intracellular signal transduction
A4R43_RS08150	COG0583	DNA-binding transcription factor activity
A4R43_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS08170	COG1309	transcriptional regulator
A4R43_RS08175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R43_RS08185	COG4106	trans-aconitate 2-methyltransferase activity
A4R43_RS08195	COG0477	Major facilitator Superfamily
A4R43_RS08200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4R43_RS08205	COG1733	regulation of RNA biosynthetic process
A4R43_RS08245	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS08255	COG2318	DinB family
A4R43_RS08285	COG1136	(ABC) transporter
A4R43_RS08290	COG0577	efflux transmembrane transporter activity
A4R43_RS08290	COG1136	(ABC) transporter
A4R43_RS08305	COG0436	Aminotransferase
A4R43_RS08315	COG0596	Alpha beta hydrolase
A4R43_RS08340	COG0477	Major facilitator Superfamily
A4R43_RS08380	COG2124	cytochrome p450
A4R43_RS08395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R43_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS08445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_RS08455	COG0463	Glycosyl transferase, family 2
A4R43_RS08475	COG1435	thymidine kinase activity
A4R43_RS08500	COG0640	Transcriptional regulator
A4R43_RS08520	COG2226	methyltransferase
A4R43_RS08530	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R43_RS08555	COG3795	YCII-related domain
A4R43_RS08560	COG4941	Belongs to the sigma-70 factor family
A4R43_RS08580	COG0702	epimerase
A4R43_RS08605	COG3795	YCII-related domain
A4R43_RS08610	COG4941	Belongs to the sigma-70 factor family
A4R43_RS08620	COG1733	regulation of RNA biosynthetic process
A4R43_RS08625	COG0702	epimerase
A4R43_RS08635	COG0640	Transcriptional regulator
A4R43_RS08645	COG1131	(ABC) transporter
A4R43_RS08650	COG1725	Transcriptional regulator
A4R43_RS08670	COG4221	oxidoreductase activity
A4R43_RS08680	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A4R43_RS08715	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
A4R43_RS08720	COG1846	Transcriptional regulator
A4R43_RS08730	COG1024	Enoyl-CoA hydratase
A4R43_RS08760	COG4974	Belongs to the 'phage' integrase family
A4R43_RS08775	COG4941	Belongs to the sigma-70 factor family
A4R43_RS08780	COG3795	YCII-related domain
A4R43_RS08840	COG4941	Belongs to the sigma-70 factor family
A4R43_RS08850	COG1522	sequence-specific DNA binding
A4R43_RS08860	COG0590	tRNA wobble adenosine to inosine editing
A4R43_RS08875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4R43_RS08885	COG0596	Alpha beta hydrolase
A4R43_RS08920	COG0667	Aldo Keto reductase
A4R43_RS08925	COG4941	Belongs to the sigma-70 factor family
A4R43_RS08935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4R43_RS08940	COG0702	epimerase
A4R43_RS08950	COG0431	NADPH-dependent FMN reductase
A4R43_RS08955	COG0477	Major facilitator Superfamily
A4R43_RS09030	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4R43_RS09060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R43_RS09065	COG0601	transmembrane transport
A4R43_RS09070	COG4166	transmembrane transport
A4R43_RS09080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_RS09085	COG3537	Alpha-1,2-mannosidase
A4R43_RS09100	COG0039	L-malate dehydrogenase activity
A4R43_RS09105	COG3104	oligopeptide transport
A4R43_RS09110	COG0339	signal peptide processing
A4R43_RS09120	COG1968	undecaprenyl-diphosphatase activity
A4R43_RS09125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS09130	COG0667	Aldo Keto reductase
A4R43_RS09145	COG0506	proline dehydrogenase activity
A4R43_RS09150	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS09165	COG0673	inositol 2-dehydrogenase activity
A4R43_RS09170	COG0366	Alpha amylase catalytic
A4R43_RS09170	COG1470	cell adhesion involved in biofilm formation
A4R43_RS09175	COG1349	DNA-binding transcription factor activity
A4R43_RS09185	COG3842	ATPase activity
A4R43_RS09190	COG0395	ABC-type sugar transport system, permease component
A4R43_RS09205	COG1349	DNA-binding transcription factor activity
A4R43_RS09220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4R43_RS09235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS09240	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS09275	COG3795	YCII-related domain
A4R43_RS09280	COG4941	Belongs to the sigma-70 factor family
A4R43_RS09285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_RS09320	COG1201	RNA secondary structure unwinding
A4R43_RS09345	COG0515	serine threonine protein kinase
A4R43_RS09345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R43_RS09380	COG1733	regulation of RNA biosynthetic process
A4R43_RS09395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R43_RS09400	COG2124	cytochrome p450
A4R43_RS09415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4R43_RS09445	COG1120	ATPase activity
A4R43_RS09455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS09470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4R43_RS09495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4R43_RS09525	COG2211	Major facilitator Superfamily
A4R43_RS09535	COG2271	Major facilitator Superfamily
A4R43_RS09565	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_RS09580	COG1295	ribonuclease BN
A4R43_RS09590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_RS09595	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A4R43_RS09610	COG4608	Belongs to the ABC transporter superfamily
A4R43_RS09615	COG0444	Belongs to the ABC transporter superfamily
A4R43_RS09640	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS09650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4R43_RS09655	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_RS09675	COG0596	Alpha beta hydrolase
A4R43_RS09695	COG1760	l-serine dehydratase
A4R43_RS09730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4R43_RS09735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_RS09750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_RS09755	COG2146	nitrite reductase [NAD(P)H] activity
A4R43_RS09760	COG1414	Transcriptional regulator
A4R43_RS09765	COG0477	Major facilitator Superfamily
A4R43_RS09775	COG0789	Transcriptional regulator
A4R43_RS09790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS09800	COG2226	methyltransferase
A4R43_RS09805	COG3321	synthase
A4R43_RS09805	COG0604	alcohol dehydrogenase
A4R43_RS09830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS09850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4R43_RS09880	COG2814	Major facilitator Superfamily
A4R43_RS09890	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS09895	COG2197	response regulator
A4R43_RS09900	COG4585	Histidine kinase
A4R43_RS09910	COG2378	regulation of single-species biofilm formation
A4R43_RS09915	COG0596	Alpha beta hydrolase
A4R43_RS09940	COG3629	intracellular signal transduction
A4R43_RS09940	COG3903	Transcriptional regulator
A4R43_RS09945	COG1309	transcriptional regulator
A4R43_RS09955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R43_RS09960	COG0477	Major facilitator Superfamily
A4R43_RS09970	COG1120	ATPase activity
A4R43_RS09975	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS09980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS09985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R43_RS09990	COG2375	cellular response to nickel ion
A4R43_RS09995	COG1535	isochorismatase
A4R43_RS09995	COG3433	isochorismatase activity
A4R43_RS10000	COG1535	isochorismatase
A4R43_RS10000	COG3433	isochorismatase activity
A4R43_RS10005	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4R43_RS10010	COG1169	isochorismate synthase
A4R43_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS10035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_RS10065	COG0667	Aldo Keto reductase
A4R43_RS10075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4R43_RS10080	COG0346	lactoylglutathione lyase activity
A4R43_RS10095	COG0277	FAD linked oxidase domain protein
A4R43_RS10110	COG0477	Major facilitator Superfamily
A4R43_RS10140	COG2226	methyltransferase
A4R43_RS10145	COG4977	sequence-specific DNA binding
A4R43_RS10185	COG0583	DNA-binding transcription factor activity
A4R43_RS10190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_RS10225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS10255	COG0454	-acetyltransferase
A4R43_RS10255	COG0456	acetyltransferase
A4R43_RS10260	COG1136	(ABC) transporter
A4R43_RS10290	COG0745	RESPONSE REGULATOR receiver
A4R43_RS10305	COG3395	kinase activity
A4R43_RS10310	COG0235	Class ii aldolase
A4R43_RS10315	COG1349	DNA-binding transcription factor activity
A4R43_RS10390	COG1414	Transcriptional regulator
A4R43_RS10400	COG0477	Major facilitator Superfamily
A4R43_RS10405	COG1846	Transcriptional regulator
A4R43_RS10410	COG1764	response to oxidative stress
A4R43_RS10420	COG1280	lysine exporter protein (LysE YggA)
A4R43_RS10425	COG0726	polysaccharide deacetylase
A4R43_RS10430	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS10440	COG3386	PFAM SMP-30 Gluconolaconase
A4R43_RS10450	COG1414	Transcriptional regulator
A4R43_RS10455	COG2017	converts alpha-aldose to the beta-anomer
A4R43_RS10460	COG3940	Belongs to the glycosyl hydrolase 43 family
A4R43_RS10475	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS10480	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS10490	COG1879	ABC-type sugar transport system periplasmic component
A4R43_RS10495	COG1609	Transcriptional regulator
A4R43_RS10540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4R43_RS10550	COG3226	Transcriptional regulator
A4R43_RS10555	COG0738	Major facilitator superfamily
A4R43_RS10580	COG0515	serine threonine protein kinase
A4R43_RS10585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS10590	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4R43_RS10605	COG2315	Protein conserved in bacteria
A4R43_RS10625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4R43_RS10625	COG2755	lipolytic protein G-D-S-L family
A4R43_RS10640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4R43_RS10650	COG0789	Transcriptional regulator
A4R43_RS10700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_RS10710	COG0477	Major facilitator Superfamily
A4R43_RS10765	COG4552	Acetyltransferase involved in intracellular survival and related
A4R43_RS10785	COG4581	dead DEAH box helicase
A4R43_RS10805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4R43_RS10815	COG2378	regulation of single-species biofilm formation
A4R43_RS10825	COG4447	cellulose binding
A4R43_RS10835	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4R43_RS10840	COG1597	lipid kinase activity
A4R43_RS10845	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4R43_RS10850	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A4R43_RS10890	COG1222	aaa ATPase
A4R43_RS10910	COG0517	IMP dehydrogenase activity
A4R43_RS10910	COG1994	Peptidase M50
A4R43_RS10930	COG0679	Auxin Efflux Carrier
A4R43_RS10935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4R43_RS10940	COG0140	phosphoribosyl-ATP diphosphatase activity
A4R43_RS10950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R43_RS10955	COG0646	methionine synthase
A4R43_RS10955	COG1410	methionine synthase
A4R43_RS10970	COG0477	Major facilitator Superfamily
A4R43_RS10975	COG2226	methyltransferase
A4R43_RS11010	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4R43_RS11025	COG0488	(ABC) transporter
A4R43_RS11030	COG0488	(ABC) transporter
A4R43_RS11035	COG0215	cysteine-tRNA ligase activity
A4R43_RS11040	COG0789	Transcriptional regulator
A4R43_RS11085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4R43_RS11090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A4R43_RS11095	COG1309	transcriptional regulator
A4R43_RS11115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4R43_RS11125	COG0745	RESPONSE REGULATOR receiver
A4R43_RS11130	COG2205	protein histidine kinase activity
A4R43_RS11140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_RS11150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4R43_RS11155	COG2304	oxidoreductase activity
A4R43_RS11165	COG0714	Associated with various cellular activities
A4R43_RS11180	COG0791	NLP P60 protein
A4R43_RS11180	COG3883	PFAM NLP P60 protein
A4R43_RS11195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4R43_RS11200	COG1285	pathogenesis
A4R43_RS11210	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A4R43_RS11215	COG0121	glutamine amidotransferase
A4R43_RS11220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4R43_RS11230	COG0583	DNA-binding transcription factor activity
A4R43_RS11235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4R43_RS11260	COG1309	transcriptional regulator
A4R43_RS11330	COG1716	ATPase activity
A4R43_RS11335	COG0509	glycine decarboxylation via glycine cleavage system
A4R43_RS11355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_RS11365	COG2267	carboxylic ester hydrolase activity
A4R43_RS11370	COG1648	precorrin-2 dehydrogenase activity
A4R43_RS11370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4R43_RS11400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4R43_RS11410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4R43_RS11415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4R43_RS11450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS11475	COG3971	2-oxopent-4-enoate hydratase activity
A4R43_RS11485	COG1132	(ABC) transporter
A4R43_RS11490	COG1309	transcriptional regulator
A4R43_RS11495	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_RS11500	COG1477	protein flavinylation
A4R43_RS11515	COG0745	RESPONSE REGULATOR receiver
A4R43_RS11520	COG2205	protein histidine kinase activity
A4R43_RS11530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_RS11540	COG3842	ATPase activity
A4R43_RS11550	COG1486	melibiose metabolic process
A4R43_RS11555	COG0395	ABC-type sugar transport system, permease component
A4R43_RS11560	COG1175	transmembrane transport
A4R43_RS11580	COG0488	(ABC) transporter
A4R43_RS11585	COG0640	Transcriptional regulator
A4R43_RS11605	COG3706	GGDEF domain
A4R43_RS11630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R43_RS11635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4R43_RS11670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A4R43_RS11695	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4R43_RS11715	COG4585	Histidine kinase
A4R43_RS11720	COG2197	response regulator
A4R43_RS11725	COG0439	Biotin carboxylase
A4R43_RS11730	COG5650	phosphatidylinositol metabolic process
A4R43_RS11745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4R43_RS11765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4R43_RS11770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4R43_RS11780	COG0515	serine threonine protein kinase
A4R43_RS11800	COG1595	DNA-templated transcription, initiation
A4R43_RS11805	COG0477	Major facilitator Superfamily
A4R43_RS11810	COG0583	DNA-binding transcription factor activity
A4R43_RS11820	COG0154	amidase activity
A4R43_RS11830	COG1252	NADH dehydrogenase
A4R43_RS11885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_RS11900	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS11915	COG1357	PFAM Pentapeptide repeats (8 copies)
A4R43_RS11990	COG1309	transcriptional regulator
A4R43_RS12000	COG3903	Transcriptional regulator
A4R43_RS12000	COG3629	intracellular signal transduction
A4R43_RS12005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4R43_RS12045	COG1846	Transcriptional regulator
A4R43_RS12050	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS12055	COG1846	Transcriptional regulator
A4R43_RS12055	COG1940	carbohydrate kinase activity
A4R43_RS12060	COG0395	ABC-type sugar transport system, permease component
A4R43_RS12065	COG1175	transmembrane transport
A4R43_RS12075	COG1063	alcohol dehydrogenase
A4R43_RS12080	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_RS12085	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A4R43_RS12100	COG2267	carboxylic ester hydrolase activity
A4R43_RS12120	COG0583	DNA-binding transcription factor activity
A4R43_RS12125	COG2851	Citrate transporter
A4R43_RS12145	COG1653	transport
A4R43_RS12160	COG0515	serine threonine protein kinase
A4R43_RS12195	COG3345	alpha-galactosidase
A4R43_RS12215	COG2197	response regulator
A4R43_RS12350	COG1674	ftsk spoiiie
A4R43_RS12365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4R43_RS12385	COG0515	serine threonine protein kinase
A4R43_RS12440	COG3629	intracellular signal transduction
A4R43_RS12440	COG3903	Transcriptional regulator
A4R43_RS12540	COG0222	ribosome binding
A4R43_RS12545	COG0515	serine threonine protein kinase
A4R43_RS12545	COG2815	serine threonine protein kinase
A4R43_RS12560	COG1278	Cold shock
A4R43_RS12570	COG0697	spore germination
A4R43_RS12585	COG2226	methyltransferase
A4R43_RS12600	COG0154	amidase activity
A4R43_RS12620	COG2234	aminopeptidase activity
A4R43_RS12655	COG1309	transcriptional regulator
A4R43_RS12685	COG1819	glycosyl
A4R43_RS12690	COG1505	serine-type exopeptidase activity
A4R43_RS12700	COG1819	glycosyl
A4R43_RS12705	COG2124	cytochrome p450
A4R43_RS12710	COG0515	serine threonine protein kinase
A4R43_RS12725	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4R43_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS12735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R43_RS12735	COG3321	synthase
A4R43_RS12745	COG2801	Transposase and inactivated derivatives
A4R43_RS12755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4R43_RS12765	COG0028	Belongs to the TPP enzyme family
A4R43_RS12775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R43_RS12805	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_RS12825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4R43_RS12835	COG1119	ATPase activity
A4R43_RS12840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_RS12850	COG0477	Major facilitator Superfamily
A4R43_RS12860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_RS12885	COG0484	heat shock protein binding
A4R43_RS12890	COG0484	heat shock protein binding
A4R43_RS12900	COG0301	tRNA thio-modification
A4R43_RS12925	COG3237	CsbD-like
A4R43_RS12940	COG1595	DNA-templated transcription, initiation
A4R43_RS13020	COG1120	ATPase activity
A4R43_RS13025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS13030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS13035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4R43_RS13055	COG0477	Major facilitator Superfamily
A4R43_RS13080	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS13085	COG1129	ABC transporter
A4R43_RS13140	COG2072	flavoprotein involved in K transport
A4R43_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS13215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS13225	COG0477	Major facilitator Superfamily
A4R43_RS13230	COG1846	Transcriptional regulator
A4R43_RS13240	COG3226	Transcriptional regulator
A4R43_RS13255	COG1959	2 iron, 2 sulfur cluster binding
A4R43_RS13260	COG0515	serine threonine protein kinase
A4R43_RS13260	COG2815	serine threonine protein kinase
A4R43_RS13275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS13340	COG1929	Belongs to the glycerate kinase type-1 family
A4R43_RS13350	COG1408	metallophosphoesterase
A4R43_RS13355	COG1063	alcohol dehydrogenase
A4R43_RS13360	COG0129	dihydroxy-acid dehydratase activity
A4R43_RS13395	COG0454	-acetyltransferase
A4R43_RS13420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4R43_RS13425	COG0515	serine threonine protein kinase
A4R43_RS13425	COG2815	serine threonine protein kinase
A4R43_RS13435	COG1609	Transcriptional regulator
A4R43_RS13445	COG1733	regulation of RNA biosynthetic process
A4R43_RS13450	COG0222	ribosome binding
A4R43_RS13470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4R43_RS13475	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS13480	COG0477	Major facilitator Superfamily
A4R43_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS13550	COG1228	amidohydrolase
A4R43_RS13560	COG0657	acetylesterase activity
A4R43_RS13570	COG4172	Belongs to the ABC transporter superfamily
A4R43_RS13575	COG0747	negative chemotaxis
A4R43_RS13580	COG0601	transmembrane transport
A4R43_RS13605	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS13615	COG1063	alcohol dehydrogenase
A4R43_RS13620	COG0667	Aldo Keto reductase
A4R43_RS13635	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS13640	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_RS13645	COG1802	Transcriptional regulator
A4R43_RS13650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_RS13695	COG0596	Alpha beta hydrolase
A4R43_RS13705	COG5650	phosphatidylinositol metabolic process
A4R43_RS13710	COG0174	glutamine synthetase
A4R43_RS13730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4R43_RS13735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4R43_RS13750	COG2326	polyphosphate kinase activity
A4R43_RS13755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4R43_RS13770	COG0488	(ABC) transporter
A4R43_RS13790	COG1595	DNA-templated transcription, initiation
A4R43_RS13800	COG1302	Protein conserved in bacteria
A4R43_RS13845	COG1793	dna ligase
A4R43_RS13870	COG0398	Pfam SNARE associated Golgi protein
A4R43_RS13885	COG0174	glutamine synthetase
A4R43_RS13895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4R43_RS13915	COG3220	belongs to the UPF0276 family
A4R43_RS13925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS13935	COG3253	May function as heme-dependent peroxidase
A4R43_RS13940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A4R43_RS13945	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4R43_RS13955	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A4R43_RS13960	COG3766	membrane
A4R43_RS13980	COG2197	response regulator
A4R43_RS14005	COG0183	Belongs to the thiolase family
A4R43_RS14010	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_RS14010	COG1024	Enoyl-CoA hydratase
A4R43_RS14030	COG2205	protein histidine kinase activity
A4R43_RS14035	COG0745	RESPONSE REGULATOR receiver
A4R43_RS14065	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS14095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4R43_RS14105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4R43_RS14105	COG2755	lipolytic protein G-D-S-L family
A4R43_RS14110	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS14125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4R43_RS14130	COG0531	amino acid
A4R43_RS14135	COG0569	domain protein
A4R43_RS14175	COG0756	dUTP diphosphatase activity
A4R43_RS14195	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_RS14215	COG1733	regulation of RNA biosynthetic process
A4R43_RS14220	COG0488	(ABC) transporter
A4R43_RS14225	COG1940	carbohydrate kinase activity
A4R43_RS14230	COG1309	transcriptional regulator
A4R43_RS14235	COG2124	cytochrome p450
A4R43_RS14255	COG1160	GTP binding
A4R43_RS14275	COG0475	glutathione-regulated potassium exporter activity
A4R43_RS14285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4R43_RS14290	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4R43_RS14325	COG0504	CTP synthase activity
A4R43_RS14330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4R43_RS14350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4R43_RS14365	COG0647	UMP catabolic process
A4R43_RS14390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4R43_RS14395	COG2094	Belongs to the DNA glycosylase MPG family
A4R43_RS14420	COG0165	Argininosuccinate lyase
A4R43_RS14425	COG1438	arginine binding
A4R43_RS14435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4R43_RS14440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4R43_RS14445	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4R43_RS14450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4R43_RS14465	COG0072	phenylalanine-tRNA ligase activity
A4R43_RS14465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4R43_RS14470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4R43_RS14475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R43_RS14480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4R43_RS14485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4R43_RS14505	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A4R43_RS14530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
A4R43_RS14535	COG2610	gluconate transmembrane transporter activity
A4R43_RS14540	COG2706	6-phosphogluconolactonase activity
A4R43_RS14545	COG3415	Transposase
A4R43_RS14545	COG2801	Transposase and inactivated derivatives
A4R43_RS14555	COG1175	transmembrane transport
A4R43_RS14560	COG0395	ABC-type sugar transport system, permease component
A4R43_RS14565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4R43_RS14570	COG1316	TRANSCRIPTIONal
A4R43_RS14585	COG3290	protein histidine kinase activity
A4R43_RS14590	COG1301	dicarboxylic acid transport
A4R43_RS14610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_RS14640	COG1793	dna ligase
A4R43_RS14640	COG3285	dna ligase
A4R43_RS14655	COG0640	Transcriptional regulator
A4R43_RS14665	COG1126	abc transporter atp-binding protein
A4R43_RS14670	COG0765	amino acid transport
A4R43_RS14675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_RS14695	COG0390	transport system, permease component
A4R43_RS14705	COG0702	epimerase
A4R43_RS14710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_RS14730	COG0667	Aldo Keto reductase
A4R43_RS14735	COG1070	Carbohydrate kinase
A4R43_RS14745	COG1609	Transcriptional regulator
A4R43_RS14750	COG1879	ABC-type sugar transport system periplasmic component
A4R43_RS14755	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS14760	COG1129	ABC transporter
A4R43_RS14780	COG1396	sequence-specific DNA binding
A4R43_RS14785	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
A4R43_RS14795	COG4946	Tricorn protease homolog
A4R43_RS14795	COG1506	peptidase
A4R43_RS14795	COG0823	Involved in the tonB-independent uptake of proteins
A4R43_RS14805	COG1131	(ABC) transporter
A4R43_RS14840	COG1131	(ABC) transporter
A4R43_RS14855	COG4585	Histidine kinase
A4R43_RS14860	COG2197	response regulator
A4R43_RS14865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A4R43_RS14865	COG0237	dephospho-CoA kinase activity
A4R43_RS14880	COG3321	synthase
A4R43_RS14880	COG0604	alcohol dehydrogenase
A4R43_RS14880	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS14885	COG3321	synthase
A4R43_RS14885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4R43_RS14890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R43_RS14915	COG0539	negative regulation of cytoplasmic translation
A4R43_RS14920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4R43_RS14940	COG1511	domain protein
A4R43_RS14975	COG1917	Cupin 2, conserved barrel domain protein
A4R43_RS14975	COG2207	Transcriptional regulator
A4R43_RS15120	COG1388	LysM domain
A4R43_RS15120	COG3103	Sh3 type 3 domain protein
A4R43_RS15120	COG0791	NLP P60 protein
A4R43_RS15145	COG4585	Histidine kinase
A4R43_RS15150	COG2197	response regulator
A4R43_RS15170	COG1136	(ABC) transporter
A4R43_RS15175	COG0494	nUDIX hydrolase
A4R43_RS15185	COG3903	Transcriptional regulator
A4R43_RS15185	COG3629	intracellular signal transduction
A4R43_RS15205	COG3209	COG3209 Rhs family protein
A4R43_RS15285	COG4585	Histidine kinase
A4R43_RS15290	COG2197	response regulator
A4R43_RS15305	COG0697	spore germination
A4R43_RS15320	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS15325	COG0784	Response regulator, receiver
A4R43_RS15330	COG4251	negative regulation of phosphorylation
A4R43_RS15345	COG1302	Protein conserved in bacteria
A4R43_RS15410	COG1395	domain, Protein
A4R43_RS15420	COG0583	DNA-binding transcription factor activity
A4R43_RS15430	COG0596	Alpha beta hydrolase
A4R43_RS15450	COG1063	alcohol dehydrogenase
A4R43_RS15475	COG1309	transcriptional regulator
A4R43_RS15505	COG1309	transcriptional regulator
A4R43_RS15520	COG2409	Drug exporters of the RND superfamily
A4R43_RS15525	COG2197	response regulator
A4R43_RS15535	COG1131	(ABC) transporter
A4R43_RS15570	COG0702	epimerase
A4R43_RS15590	COG1522	sequence-specific DNA binding
A4R43_RS15595	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4R43_RS15620	COG1309	transcriptional regulator
A4R43_RS15655	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A4R43_RS15665	COG0714	Associated with various cellular activities
A4R43_RS15685	COG1573	uracil-dna glycosylase
A4R43_RS15725	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A4R43_RS15730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4R43_RS15740	COG0028	Belongs to the TPP enzyme family
A4R43_RS15780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4R43_RS15790	COG3345	alpha-galactosidase
A4R43_RS15810	COG5492	domain, Protein
A4R43_RS15825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_RS15830	COG1414	Transcriptional regulator
A4R43_RS15835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R43_RS15885	COG2197	response regulator
A4R43_RS15905	COG4214	carbohydrate transport
A4R43_RS15915	COG4213	ABC transporter substrate-binding protein
A4R43_RS15935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4R43_RS15955	COG2313	pseudouridylate synthase activity
A4R43_RS15980	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R43_RS15985	COG1490	D-aminoacyl-tRNA deacylase activity
A4R43_RS16010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_RS16015	COG2188	Transcriptional regulator
A4R43_RS16025	COG2070	2-Nitropropane dioxygenase
A4R43_RS16035	COG1024	Enoyl-CoA hydratase
A4R43_RS16040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4R43_RS16065	COG2226	methyltransferase
A4R43_RS16070	COG2124	cytochrome p450
A4R43_RS16075	COG0183	Belongs to the thiolase family
A4R43_RS16085	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS16090	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS16095	COG1024	Enoyl-CoA hydratase
A4R43_RS16115	COG0596	Alpha beta hydrolase
A4R43_RS16120	COG0110	maltose O-acetyltransferase activity
A4R43_RS16125	COG0183	Belongs to the thiolase family
A4R43_RS16130	COG1309	transcriptional regulator
A4R43_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS16140	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16145	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS16150	COG1024	Enoyl-CoA hydratase
A4R43_RS16155	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16160	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4R43_RS16180	COG0346	lactoylglutathione lyase activity
A4R43_RS16185	COG2267	carboxylic ester hydrolase activity
A4R43_RS16190	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16200	COG1053	succinate dehydrogenase
A4R43_RS16220	COG2030	dehydratase
A4R43_RS16240	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16245	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16250	COG4977	sequence-specific DNA binding
A4R43_RS16255	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4R43_RS16265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4R43_RS16270	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16275	COG1309	transcriptional regulator
A4R43_RS16285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS16305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R43_RS16305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R43_RS16305	COG1703	isobutyryl-CoA mutase activity
A4R43_RS16320	COG2018	Roadblock/LC7 domain
A4R43_RS16335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_RS16340	COG0019	diaminopimelate decarboxylase activity
A4R43_RS16345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A4R43_RS16370	COG1566	PFAM secretion protein HlyD family protein
A4R43_RS16385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS16390	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16405	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS16420	COG1672	PFAM Archaeal ATPase
A4R43_RS16420	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_RS16445	COG1946	Acyl-CoA thioesterase
A4R43_RS16480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4R43_RS16505	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4R43_RS16515	COG1940	carbohydrate kinase activity
A4R43_RS16525	COG0003	Pfam Anion-transporting ATPase
A4R43_RS16610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R43_RS16620	COG3263	regulation of cellular component size
A4R43_RS16625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4R43_RS16650	COG1799	cell septum assembly
A4R43_RS16690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_RS16700	COG2318	DinB family
A4R43_RS16710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4R43_RS16715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4R43_RS16720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4R43_RS16730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4R43_RS16735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4R43_RS16790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_RS16795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS16810	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16815	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS16830	COG0123	including yeast histone deacetylase and acetoin utilization protein
A4R43_RS16845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4R43_RS16850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4R43_RS16865	COG2936	dipeptidyl-peptidase activity
A4R43_RS16890	COG0596	Alpha beta hydrolase
A4R43_RS16900	COG2321	neutral zinc metallopeptidase
A4R43_RS16905	COG1505	serine-type exopeptidase activity
A4R43_RS16915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4R43_RS16925	COG1228	amidohydrolase
A4R43_RS16935	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4R43_RS16940	COG4279	zinc finger
A4R43_RS16970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_RS16975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4R43_RS16980	COG1388	LysM domain
A4R43_RS16995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4R43_RS17010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4R43_RS17015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4R43_RS17025	COG1196	nuclear chromosome segregation
A4R43_RS17040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4R43_RS17045	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4R43_RS17050	COG3609	addiction module antidote protein, CC2985 family
A4R43_RS17055	COG2358	TRAP transporter, solute receptor (TAXI family
A4R43_RS17060	COG2205	protein histidine kinase activity
A4R43_RS17070	COG1126	abc transporter atp-binding protein
A4R43_RS17075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_RS17080	COG0765	amino acid transport
A4R43_RS17085	COG0765	amino acid transport
A4R43_RS17095	COG1053	succinate dehydrogenase
A4R43_RS17115	COG0800	Aldolase
A4R43_RS17125	COG2137	regulation of response to DNA damage stimulus
A4R43_RS17130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4R43_RS17140	COG0443	Heat shock 70 kDa protein
A4R43_RS17145	COG1201	RNA secondary structure unwinding
A4R43_RS17150	COG0242	peptide deformylase activity
A4R43_RS17190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_RS17195	COG0583	DNA-binding transcription factor activity
A4R43_RS17225	COG0142	geranyltranstransferase activity
A4R43_RS17240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS17255	COG2815	serine threonine protein kinase
A4R43_RS17255	COG0515	serine threonine protein kinase
A4R43_RS17265	COG2268	Band 7 protein
A4R43_RS17285	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A4R43_RS17300	COG0583	DNA-binding transcription factor activity
A4R43_RS17320	COG0067	glutamate synthase
A4R43_RS17320	COG0069	glutamate synthase activity
A4R43_RS17320	COG0070	glutamate synthase
A4R43_RS17325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4R43_RS17360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4R43_RS17370	COG1124	(ABC) transporter
A4R43_RS17380	COG0601	transmembrane transport
A4R43_RS17390	COG0159	tryptophan synthase activity
A4R43_RS17395	COG0133	tryptophan synthase activity
A4R43_RS17400	COG0134	indole-3-glycerol-phosphate synthase activity
A4R43_RS17410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4R43_RS17415	COG1309	transcriptional regulator
A4R43_RS17420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4R43_RS17430	COG0107	imidazoleglycerol-phosphate synthase activity
A4R43_RS17455	COG3629	intracellular signal transduction
A4R43_RS17455	COG3903	Transcriptional regulator
A4R43_RS17465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4R43_RS17470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4R43_RS17485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R43_RS17490	COG1174	glycine betaine transport
A4R43_RS17495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R43_RS17505	COG2018	Roadblock/LC7 domain
A4R43_RS17515	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS17530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R43_RS17540	COG0513	Belongs to the DEAD box helicase family
A4R43_RS17555	COG2843	Capsule synthesis protein
A4R43_RS17575	COG3958	Transketolase
A4R43_RS17580	COG3959	Transketolase, thiamine diphosphate binding domain
A4R43_RS17605	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A4R43_RS17610	COG0131	Imidazoleglycerol-phosphate dehydratase
A4R43_RS17615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4R43_RS17620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R43_RS17625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4R43_RS17640	COG2197	response regulator
A4R43_RS17660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4R43_RS17675	COG1674	ftsk spoiiie
A4R43_RS17700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4R43_RS17700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4R43_RS17715	COG1404	Belongs to the peptidase S8 family
A4R43_RS17720	COG0157	Belongs to the NadC ModD family
A4R43_RS17725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4R43_RS17745	COG0501	Belongs to the peptidase M48B family
A4R43_RS17760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4R43_RS17765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4R43_RS17770	COG0659	secondary active sulfate transmembrane transporter activity
A4R43_RS17775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4R43_RS17780	COG2124	cytochrome p450
A4R43_RS17800	COG1595	DNA-templated transcription, initiation
A4R43_RS17805	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS17820	COG1876	peptidase activity
A4R43_RS17830	COG1136	(ABC) transporter
A4R43_RS17855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4R43_RS17865	COG2010	Cytochrome c
A4R43_RS17870	COG1845	cytochrome c oxidase, subunit III
A4R43_RS17880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4R43_RS17890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4R43_RS17905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R43_RS17915	COG1414	Transcriptional regulator
A4R43_RS17925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_RS17940	COG0667	Aldo Keto reductase
A4R43_RS17945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4R43_RS17955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4R43_RS17990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4R43_RS17995	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_RS18000	COG1309	transcriptional regulator
A4R43_RS18030	COG0321	lipoyl(octanoyl) transferase activity
A4R43_RS18055	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4R43_RS18060	COG0586	Pfam SNARE associated Golgi protein
A4R43_RS18085	COG1376	ErfK ybiS ycfS ynhG family protein
A4R43_RS18100	COG0587	DNA-directed DNA polymerase activity
A4R43_RS18105	COG2188	Transcriptional regulator
A4R43_RS18110	COG1113	amino acid transport
A4R43_RS18140	COG2267	carboxylic ester hydrolase activity
A4R43_RS18145	COG1309	transcriptional regulator
A4R43_RS18155	COG0596	Alpha beta hydrolase
A4R43_RS18175	COG0702	epimerase
A4R43_RS18200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A4R43_RS18210	COG1620	l-lactate permease
A4R43_RS18215	COG3201	nicotinamide mononucleotide transporter
A4R43_RS18220	COG0668	transmembrane transport
A4R43_RS18245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4R43_RS18250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R43_RS18290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A4R43_RS18325	COG2197	response regulator
A4R43_RS18330	COG0432	Pfam Uncharacterised protein family UPF0047
A4R43_RS18350	COG0442	prolyl-tRNA aminoacylation
A4R43_RS18370	COG3022	response to hydroperoxide
A4R43_RS18375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_RS18395	COG0513	Belongs to the DEAD box helicase family
A4R43_RS18430	COG2807	transmembrane transport
A4R43_RS18435	COG2186	Transcriptional regulator
A4R43_RS18440	COG1733	regulation of RNA biosynthetic process
A4R43_RS18445	COG0702	epimerase
A4R43_RS18460	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS18480	COG0454	-acetyltransferase
A4R43_RS18480	COG0456	acetyltransferase
A4R43_RS18495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4R43_RS18500	COG0750	zinc metalloprotease
A4R43_RS18505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4R43_RS18525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4R43_RS18530	COG1695	Transcriptional regulator
A4R43_RS18550	COG0233	cytoplasmic translational termination
A4R43_RS18555	COG0528	UMP kinase activity
A4R43_RS18560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4R43_RS18565	COG0052	Belongs to the universal ribosomal protein uS2 family
A4R43_RS18575	COG1191	sigma factor activity
A4R43_RS18595	COG0792	nuclease activity
A4R43_RS18605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4R43_RS18610	COG0681	Belongs to the peptidase S26 family
A4R43_RS18615	COG0335	large ribosomal subunit rRNA binding
A4R43_RS18620	COG0336	Belongs to the RNA methyltransferase TrmD family
A4R43_RS18635	COG0228	four-way junction DNA binding
A4R43_RS18660	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4R43_RS18670	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4R43_RS18700	COG0667	Aldo Keto reductase
A4R43_RS18705	COG2873	o-acetylhomoserine
A4R43_RS18710	COG1832	CoA-binding protein
A4R43_RS18715	COG4266	Belongs to the allantoicase family
A4R43_RS18720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_RS18750	COG2233	PERMEase
A4R43_RS18755	COG1309	transcriptional regulator
A4R43_RS18775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_RS18795	COG3835	regulator
A4R43_RS18805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4R43_RS18810	COG1414	Transcriptional regulator
A4R43_RS18815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R43_RS18825	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A4R43_RS18830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_RS18850	COG1254	Belongs to the acylphosphatase family
A4R43_RS18870	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A4R43_RS18875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A4R43_RS18880	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4R43_RS18890	COG0367	asparagine synthase
A4R43_RS18895	COG1940	carbohydrate kinase activity
A4R43_RS18925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4R43_RS18930	COG0571	ribonuclease III activity
A4R43_RS18935	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4R43_RS18955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4R43_RS18960	COG0742	ribosomal rna small subunit methyltransferase
A4R43_RS18965	COG3973	AAA domain
A4R43_RS18970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS19015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_RS19070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4R43_RS19075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_RS19085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_RS19095	COG3279	Response regulator of the LytR AlgR family
A4R43_RS19100	COG3275	phosphorelay sensor kinase activity
A4R43_RS19110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_RS19140	COG3507	Belongs to the glycosyl hydrolase 43 family
A4R43_RS19150	COG0673	inositol 2-dehydrogenase activity
A4R43_RS19155	COG1116	anion transmembrane transporter activity
A4R43_RS19155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R43_RS19165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R43_RS19190	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_RS19220	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS19235	COG1643	Atp-dependent helicase
A4R43_RS19250	COG0475	glutathione-regulated potassium exporter activity
A4R43_RS19260	COG2814	Major facilitator Superfamily
A4R43_RS19265	COG2910	NAD(P)H-binding
A4R43_RS19290	COG1120	ATPase activity
A4R43_RS19295	COG4122	O-methyltransferase activity
A4R43_RS19300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4R43_RS19305	COG2186	Transcriptional regulator
A4R43_RS19310	COG1760	l-serine dehydratase
A4R43_RS19315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4R43_RS19320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4R43_RS19325	COG0509	glycine decarboxylation via glycine cleavage system
A4R43_RS19330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4R43_RS19335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4R43_RS19335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4R43_RS19345	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS19350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4R43_RS19360	COG0531	amino acid
A4R43_RS19365	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_RS19380	COG0673	inositol 2-dehydrogenase activity
A4R43_RS19385	COG1609	Transcriptional regulator
A4R43_RS19390	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_RS19410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_RS19420	COG3718	enzyme involved in inositol metabolism
A4R43_RS19425	COG3962	Belongs to the TPP enzyme family
A4R43_RS19435	COG3795	YCII-related domain
A4R43_RS19475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4R43_RS19485	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_RS19490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R43_RS19495	COG1063	alcohol dehydrogenase
A4R43_RS19500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_RS19500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_RS19505	COG2213	PTS system mannitol-specific
A4R43_RS19505	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_RS19515	COG1105	Belongs to the carbohydrate kinase PfkB family
A4R43_RS19520	COG1349	DNA-binding transcription factor activity
A4R43_RS19530	COG1414	Transcriptional regulator
A4R43_RS19535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_RS19540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4R43_RS19545	COG3485	protocatechuate 3,4-dioxygenase
A4R43_RS19550	COG3485	protocatechuate 3,4-dioxygenase
A4R43_RS19560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4R43_RS19565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4R43_RS19580	COG1929	Belongs to the glycerate kinase type-1 family
A4R43_RS19620	COG1984	allophanate hydrolase subunit 2
A4R43_RS19625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4R43_RS19630	COG4336	lyase activity
A4R43_RS19635	COG2814	Major facilitator Superfamily
A4R43_RS19670	COG1461	Dihydroxyacetone kinase
A4R43_RS19675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4R43_RS19680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4R43_RS19715	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R43_RS19720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS19735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4R43_RS19745	COG1920	GTP binding
A4R43_RS19760	COG3629	intracellular signal transduction
A4R43_RS19760	COG3903	Transcriptional regulator
A4R43_RS19770	COG0066	3-isopropylmalate dehydratase activity
A4R43_RS19775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4R43_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS19800	COG0183	Belongs to the thiolase family
A4R43_RS19810	COG2205	protein histidine kinase activity
A4R43_RS19840	COG2409	Drug exporters of the RND superfamily
A4R43_RS19890	COG1131	(ABC) transporter
A4R43_RS19900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A4R43_RS19930	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4R43_RS19935	COG1733	regulation of RNA biosynthetic process
A4R43_RS19940	COG2132	Multicopper oxidase
A4R43_RS19950	COG0583	DNA-binding transcription factor activity
A4R43_RS19960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_RS19965	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_RS19990	COG3959	Transketolase, thiamine diphosphate binding domain
A4R43_RS19995	COG3958	Transketolase
A4R43_RS20000	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS20010	COG1309	transcriptional regulator
A4R43_RS20030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_RS20035	COG2226	methyltransferase
A4R43_RS20040	COG1937	Protein conserved in bacteria
A4R43_RS20045	COG1309	transcriptional regulator
A4R43_RS20050	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS20070	COG0640	Transcriptional regulator
A4R43_RS20130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4R43_RS20140	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_RS20145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4R43_RS20150	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_RS20155	COG1404	Belongs to the peptidase S8 family
A4R43_RS20190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4R43_RS20195	COG0440	acetolactate synthase activity
A4R43_RS20210	COG0129	dihydroxy-acid dehydratase activity
A4R43_RS20240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4R43_RS20250	COG0154	amidase activity
A4R43_RS20255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4R43_RS20265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS20270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4R43_RS20285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4R43_RS20285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_RS20295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_RS20300	COG3386	PFAM SMP-30 Gluconolaconase
A4R43_RS20315	COG0482	sulfurtransferase activity
A4R43_RS20325	COG0477	Major facilitator Superfamily
A4R43_RS20340	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4R43_RS20350	COG1307	EDD domain protein, DegV family
A4R43_RS20360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4R43_RS20370	COG0386	Belongs to the glutathione peroxidase family
A4R43_RS20415	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4R43_RS20440	COG0110	maltose O-acetyltransferase activity
A4R43_RS20450	COG1388	LysM domain
A4R43_RS20450	COG3103	Sh3 type 3 domain protein
A4R43_RS20450	COG0791	NLP P60 protein
A4R43_RS20480	COG0346	lactoylglutathione lyase activity
A4R43_RS20490	COG0640	Transcriptional regulator
A4R43_RS20505	COG2814	Major facilitator Superfamily
A4R43_RS20510	COG0789	Transcriptional regulator
A4R43_RS20515	COG1846	Transcriptional regulator
A4R43_RS20520	COG0596	Alpha beta hydrolase
A4R43_RS20530	COG0640	Transcriptional regulator
A4R43_RS20535	COG2267	carboxylic ester hydrolase activity
A4R43_RS20560	COG0346	lactoylglutathione lyase activity
A4R43_RS20575	COG4195	phage-related replication protein
A4R43_RS20600	COG4585	Histidine kinase
A4R43_RS20605	COG2197	response regulator
A4R43_RS20625	COG1119	ATPase activity
A4R43_RS20640	COG0010	Belongs to the arginase family
A4R43_RS20660	COG0058	SHG alpha-glucan phosphorylase activity
A4R43_RS20685	COG1846	Transcriptional regulator
A4R43_RS20690	COG2409	Drug exporters of the RND superfamily
A4R43_RS20695	COG1609	Transcriptional regulator
A4R43_RS20720	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A4R43_RS20725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_RS20730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS20735	COG0300	oxidoreductase activity
A4R43_RS20740	COG1309	transcriptional regulator
A4R43_RS20755	COG0183	Belongs to the thiolase family
A4R43_RS20760	COG0346	lactoylglutathione lyase activity
A4R43_RS20790	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_RS20805	COG1418	mRNA catabolic process
A4R43_RS20815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4R43_RS20835	COG2226	methyltransferase
A4R43_RS20845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_RS20860	COG0433	COG0433 Predicted ATPase
A4R43_RS20865	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4R43_RS20875	COG1376	ErfK ybiS ycfS ynhG family protein
A4R43_RS20905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4R43_RS20920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R43_RS20930	COG3629	intracellular signal transduction
A4R43_RS20930	COG3903	Transcriptional regulator
A4R43_RS20945	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_RS20950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_RS20950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_RS20960	COG0297	glycogen (starch) synthase activity
A4R43_RS20980	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_RS20990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R43_RS20990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R43_RS20995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R43_RS21015	COG3629	intracellular signal transduction
A4R43_RS21015	COG3903	Transcriptional regulator
A4R43_RS21020	COG2197	response regulator
A4R43_RS21030	COG0531	amino acid
A4R43_RS21070	COG1121	(ABC) transporter
A4R43_RS21085	COG1846	Transcriptional regulator
A4R43_RS21090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4R43_RS21100	COG0385	Bile acid
A4R43_RS21105	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS21110	COG0387	Pfam Sodium calcium exchanger
A4R43_RS21145	COG2018	Roadblock/LC7 domain
A4R43_RS21150	COG2205	protein histidine kinase activity
A4R43_RS21175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R43_RS21180	COG1595	DNA-templated transcription, initiation
A4R43_RS21195	COG2018	Roadblock/LC7 domain
A4R43_RS21205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4R43_RS21210	COG1116	anion transmembrane transporter activity
A4R43_RS21215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4R43_RS21220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS21230	COG1309	transcriptional regulator
A4R43_RS21240	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS21255	COG3903	Transcriptional regulator
A4R43_RS21255	COG3629	intracellular signal transduction
A4R43_RS21270	COG1316	TRANSCRIPTIONal
A4R43_RS21305	COG0017	Asparaginyl-tRNA synthetase
A4R43_RS21320	COG1131	(ABC) transporter
A4R43_RS21330	COG0745	RESPONSE REGULATOR receiver
A4R43_RS21335	COG2205	protein histidine kinase activity
A4R43_RS21360	COG4977	sequence-specific DNA binding
A4R43_RS21380	COG0583	DNA-binding transcription factor activity
A4R43_RS21395	COG2610	gluconate transmembrane transporter activity
A4R43_RS21455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4R43_RS21480	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS21500	COG0477	Major facilitator Superfamily
A4R43_RS21505	COG0583	DNA-binding transcription factor activity
A4R43_RS21510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4R43_RS21515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4R43_RS21520	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_RS21525	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS21535	COG1846	Transcriptional regulator
A4R43_RS21535	COG1940	carbohydrate kinase activity
A4R43_RS21610	COG0745	RESPONSE REGULATOR receiver
A4R43_RS21615	COG2205	protein histidine kinase activity
A4R43_RS21620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4R43_RS21630	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A4R43_RS21635	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R43_RS21705	COG2409	Drug exporters of the RND superfamily
A4R43_RS21735	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS21740	COG2897	thiosulfate sulfurtransferase activity
A4R43_RS21745	COG2814	Major facilitator Superfamily
A4R43_RS21765	COG0406	alpha-ribazole phosphatase activity
A4R43_RS21775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R43_RS21785	COG0583	DNA-binding transcription factor activity
A4R43_RS21795	COG1090	epimerase
A4R43_RS21835	COG0402	S-adenosylhomocysteine deaminase activity
A4R43_RS21895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4R43_RS21940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_RS21985	COG3883	PFAM NLP P60 protein
A4R43_RS21985	COG0791	NLP P60 protein
A4R43_RS22000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_RS22005	COG1643	Atp-dependent helicase
A4R43_RS22015	COG1131	(ABC) transporter
A4R43_RS22020	COG0671	phosphoesterase, PA-phosphatase related
A4R43_RS22040	COG2197	response regulator
A4R43_RS22045	COG4585	Histidine kinase
A4R43_RS22050	COG1819	glycosyl
A4R43_RS22070	COG1228	amidohydrolase
A4R43_RS22085	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A4R43_RS22090	COG2986	histidine ammonia-lyase
A4R43_RS22115	COG1937	Protein conserved in bacteria
A4R43_RS22155	COG4585	Histidine kinase
A4R43_RS22160	COG2197	response regulator
A4R43_RS22170	COG1846	Transcriptional regulator
A4R43_RS22190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4R43_RS22195	COG2177	Part of the ABC transporter FtsEX involved in
A4R43_RS22200	COG2884	Cell division ATP-binding protein ftsE
A4R43_RS22205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4R43_RS22225	COG2378	regulation of single-species biofilm formation
A4R43_RS22235	COG1615	UPF0182 protein
A4R43_RS22245	COG3480	Lon protease (S16) C-terminal proteolytic domain
A4R43_RS22265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4R43_RS22325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A4R43_RS22360	COG0174	glutamine synthetase
A4R43_RS22390	COG0653	protein targeting
A4R43_RS22400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_RS22400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4R43_RS22410	COG0519	Catalyzes the synthesis of GMP from XMP
A4R43_RS22435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4R43_RS22455	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_RS22465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R43_RS22465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4R43_RS22475	COG2376	Dihydroxyacetone kinase
A4R43_RS22495	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A4R43_RS22515	COG1024	Enoyl-CoA hydratase
A4R43_RS22520	COG1674	ftsk spoiiie
A4R43_RS22525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R43_RS22525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A4R43_RS22530	COG1280	lysine exporter protein (LysE YggA)
A4R43_RS22565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4R43_RS22570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4R43_RS22575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4R43_RS22580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4R43_RS22585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4R43_RS22590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4R43_RS22595	COG0356	it plays a direct role in the translocation of protons across the membrane
A4R43_RS22605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4R43_RS22615	COG2890	protein-(glutamine-N5) methyltransferase activity
A4R43_RS22620	COG0789	Transcriptional regulator
A4R43_RS22625	COG0596	Alpha beta hydrolase
A4R43_RS22630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS22640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4R43_RS22645	COG0254	rRNA binding
A4R43_RS22655	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4R43_RS22660	COG0083	homoserine kinase activity
A4R43_RS22665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4R43_RS22675	COG0019	diaminopimelate decarboxylase activity
A4R43_RS22680	COG0018	arginyl-trna synthetase
A4R43_RS22700	COG0129	dihydroxy-acid dehydratase activity
A4R43_RS22715	COG4941	Belongs to the sigma-70 factor family
A4R43_RS22730	COG1280	lysine exporter protein (LysE YggA)
A4R43_RS22735	COG0667	Aldo Keto reductase
A4R43_RS22765	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS22770	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS22775	COG1129	ABC transporter
A4R43_RS22780	COG1879	ABC-type sugar transport system periplasmic component
A4R43_RS22795	COG4952	isomerase
A4R43_RS22800	COG1879	ABC-type sugar transport system periplasmic component
A4R43_RS22810	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS22815	COG1129	ABC transporter
A4R43_RS22820	COG3250	beta-galactosidase activity
A4R43_RS22830	COG0702	epimerase
A4R43_RS22835	COG2267	carboxylic ester hydrolase activity
A4R43_RS22850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R43_RS22895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS22915	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS22950	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A4R43_RS22955	COG0535	radical SAM domain protein
A4R43_RS22965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4R43_RS22970	COG0667	Aldo Keto reductase
A4R43_RS22985	COG0154	amidase activity
A4R43_RS23010	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4R43_RS23015	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_RS23025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4R43_RS23040	COG0028	Belongs to the TPP enzyme family
A4R43_RS23070	COG1024	Enoyl-CoA hydratase
A4R43_RS23070	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_RS23075	COG0183	Belongs to the thiolase family
A4R43_RS23090	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS23100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A4R43_RS23120	COG4221	oxidoreductase activity
A4R43_RS23135	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS23145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_RS23180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4R43_RS23195	COG0346	lactoylglutathione lyase activity
A4R43_RS23200	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4R43_RS23200	COG2508	Transcriptional regulator
A4R43_RS23220	COG0686	Belongs to the AlaDH PNT family
A4R43_RS23230	COG0477	Major facilitator Superfamily
A4R43_RS23245	COG1132	(ABC) transporter
A4R43_RS23250	COG3547	Transposase (IS116 IS110 IS902 family)
A4R43_RS23285	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_RS23285	COG0567	Dehydrogenase, E1 component
A4R43_RS23305	COG1174	glycine betaine transport
A4R43_RS23310	COG1174	glycine betaine transport
A4R43_RS23315	COG0517	IMP dehydrogenase activity
A4R43_RS23315	COG1125	glycine betaine transport
A4R43_RS23340	COG0406	alpha-ribazole phosphatase activity
A4R43_RS23355	COG1597	lipid kinase activity
A4R43_RS23370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A4R43_RS23380	COG1595	DNA-templated transcription, initiation
A4R43_RS23385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4R43_RS23395	COG2135	peptidase activity
A4R43_RS23400	COG1162	GTPase activity
A4R43_RS23410	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS23425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R43_RS23430	COG1011	Hydrolase
A4R43_RS23440	COG0653	protein targeting
A4R43_RS23445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4R43_RS23450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4R43_RS23455	COG5401	PFAM Sporulation and spore germination
A4R43_RS23460	COG5002	protein histidine kinase activity
A4R43_RS23465	COG0745	RESPONSE REGULATOR receiver
A4R43_RS23470	COG1414	Transcriptional regulator
A4R43_RS23480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4R43_RS23490	COG0531	amino acid
A4R43_RS23505	COG1482	cell wall glycoprotein biosynthetic process
A4R43_RS23515	COG2835	tetraacyldisaccharide 4'-kinase activity
A4R43_RS23545	COG1994	Peptidase M50
A4R43_RS23560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R43_RS23590	COG0747	negative chemotaxis
A4R43_RS23595	COG1217	gtp-binding protein TYPA
A4R43_RS23605	COG0180	Tryptophanyl-tRNA synthetase
A4R43_RS23620	COG0745	RESPONSE REGULATOR receiver
A4R43_RS23630	COG1131	(ABC) transporter
A4R43_RS23640	COG3842	ATPase activity
A4R43_RS23655	COG2154	pterin-4-alpha-carbinolamine dehydratase
A4R43_RS23685	COG0012	GTP binding
A4R43_RS23695	COG0419	ATPase involved in DNA repair
A4R43_RS23700	COG0420	3'-5' exonuclease activity
A4R43_RS23715	COG0667	Aldo Keto reductase
A4R43_RS23720	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4R43_RS23730	COG1570	exodeoxyribonuclease VII activity
A4R43_RS23740	COG1722	exodeoxyribonuclease VII activity
A4R43_RS23755	COG0492	ferredoxin-NADP+ reductase activity
A4R43_RS23760	COG0114	fumarate hydratase activity
A4R43_RS23785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS23790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4R43_RS23795	COG1793	dna ligase
A4R43_RS23835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_RS23845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A4R43_RS23865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS23890	COG1331	Highly conserved protein containing a thioredoxin domain
A4R43_RS23900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4R43_RS23910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4R43_RS23920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4R43_RS23925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_RS23935	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A4R43_RS23940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4R43_RS23985	COG0183	Belongs to the thiolase family
A4R43_RS23990	COG2391	methyltransferase activity
A4R43_RS24010	COG1902	pentaerythritol trinitrate reductase activity
A4R43_RS24015	COG0789	Transcriptional regulator
A4R43_RS24025	COG1802	Transcriptional regulator
A4R43_RS24030	COG1953	Uracil, thiamine, allantoin
A4R43_RS24050	COG1733	regulation of RNA biosynthetic process
A4R43_RS24060	COG4585	Histidine kinase
A4R43_RS24065	COG2197	response regulator
A4R43_RS24080	COG1252	NADH dehydrogenase
A4R43_RS24105	COG1404	Belongs to the peptidase S8 family
A4R43_RS24110	COG4608	Belongs to the ABC transporter superfamily
A4R43_RS24125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R43_RS24130	COG0601	transmembrane transport
A4R43_RS24135	COG0747	negative chemotaxis
A4R43_RS24165	COG0148	phosphopyruvate hydratase activity
A4R43_RS24190	COG0500	methyltransferase
A4R43_RS24220	COG2133	pyrroloquinoline quinone binding
A4R43_RS24260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4R43_RS24285	COG0193	aminoacyl-tRNA hydrolase activity
A4R43_RS24295	COG3599	regulation of cell shape
A4R43_RS24300	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS24305	COG0488	(ABC) transporter
A4R43_RS24310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4R43_RS24315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4R43_RS24320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4R43_RS24325	COG3583	domain protein
A4R43_RS24330	COG0084	hydrolase, TatD family'
A4R43_RS24335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4R43_RS24400	COG0515	serine threonine protein kinase
A4R43_RS24420	COG2258	MOSC domain
A4R43_RS24430	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS24460	COG1309	transcriptional regulator
A4R43_RS24465	COG2910	NAD(P)H-binding
A4R43_RS24490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4R43_RS24500	COG4942	peptidase
A4R43_RS24520	COG1609	Transcriptional regulator
A4R43_RS24530	COG2723	6-phospho-beta-galactosidase activity
A4R43_RS24535	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_RS24540	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_RS24545	COG3250	beta-galactosidase activity
A4R43_RS24550	COG3507	Belongs to the glycosyl hydrolase 43 family
A4R43_RS24555	COG3408	Glycogen debranching enzyme
A4R43_RS24585	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS24595	COG0657	acetylesterase activity
A4R43_RS24600	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS24620	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS24735	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A4R43_RS24745	COG0640	Transcriptional regulator
A4R43_RS24760	COG3261	NADH dehydrogenase
A4R43_RS24760	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A4R43_RS24765	COG0651	ATP synthesis coupled electron transport
A4R43_RS24775	COG0650	Formate hydrogenlyase subunit 4
A4R43_RS24785	COG3260	NADH ubiquinone oxidoreductase 20
A4R43_RS24835	COG3629	intracellular signal transduction
A4R43_RS24835	COG3903	Transcriptional regulator
A4R43_RS24860	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_RS24870	COG0720	synthase
A4R43_RS24890	COG0390	transport system, permease component
A4R43_RS24895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4R43_RS24905	COG0745	RESPONSE REGULATOR receiver
A4R43_RS24940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_RS24950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_RS24980	COG1051	belongs to the nudix hydrolase family
A4R43_RS25010	COG0285	dihydrofolate synthase activity
A4R43_RS25015	COG0009	L-threonylcarbamoyladenylate synthase
A4R43_RS25040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4R43_RS25045	COG3002	Belongs to the UPF0753 family
A4R43_RS25055	COG0473	3-isopropylmalate dehydrogenase activity
A4R43_RS25060	COG0129	dihydroxy-acid dehydratase activity
A4R43_RS25070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A4R43_RS25100	COG3547	Transposase (IS116 IS110 IS902 family)
A4R43_RS25115	COG3328	transposase activity
A4R43_RS25160	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4R43_RS25230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4R43_RS25235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4R43_RS25250	COG1970	mechanosensitive ion channel activity
A4R43_RS25255	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4R43_RS25255	COG0315	cyclic pyranopterin monophosphate synthase activity
A4R43_RS25270	COG5002	protein histidine kinase activity
A4R43_RS25275	COG0745	RESPONSE REGULATOR receiver
A4R43_RS25315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_RS25325	COG1349	DNA-binding transcription factor activity
A4R43_RS25340	COG2860	membrane
A4R43_RS25345	COG2197	response regulator
A4R43_RS25410	COG0596	Alpha beta hydrolase
A4R43_RS25435	COG2203	Gaf domain
A4R43_RS25435	COG4585	Histidine kinase
A4R43_RS25440	COG0577	efflux transmembrane transporter activity
A4R43_RS25445	COG1136	(ABC) transporter
A4R43_RS25445	COG0577	efflux transmembrane transporter activity
A4R43_RS25460	COG0745	RESPONSE REGULATOR receiver
A4R43_RS25465	COG2205	protein histidine kinase activity
A4R43_RS25475	COG3177	Filamentation induced by cAMP protein fic
A4R43_RS25485	COG0596	Alpha beta hydrolase
A4R43_RS25585	COG1335	isochorismatase
A4R43_RS25605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS25615	COG4221	oxidoreductase activity
A4R43_RS25620	COG3415	Transposase
A4R43_RS25620	COG2801	Transposase and inactivated derivatives
A4R43_RS25635	COG0745	RESPONSE REGULATOR receiver
A4R43_RS25640	COG2205	protein histidine kinase activity
A4R43_RS25645	COG2409	Drug exporters of the RND superfamily
A4R43_RS25660	COG1063	alcohol dehydrogenase
A4R43_RS25665	COG1113	amino acid transport
A4R43_RS25675	COG1321	iron dependent repressor
A4R43_RS25685	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4R43_RS25690	COG1024	Enoyl-CoA hydratase
A4R43_RS25695	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS25715	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS25720	COG1301	dicarboxylic acid transport
A4R43_RS25740	COG2188	Transcriptional regulator
A4R43_RS25745	COG1169	isochorismate synthase
A4R43_RS25790	COG0277	FAD linked oxidase domain protein
A4R43_RS25815	COG4152	abc transporter atp-binding protein
A4R43_RS25820	COG1668	transmembrane transport
A4R43_RS25825	COG0415	Belongs to the DNA photolyase family
A4R43_RS25845	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS25855	COG1228	amidohydrolase
A4R43_RS25860	COG2017	converts alpha-aldose to the beta-anomer
A4R43_RS25880	COG0259	pyridoxamine-phosphate oxidase activity
A4R43_RS25900	COG0829	nickel cation binding
A4R43_RS25905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A4R43_RS25915	COG0804	urea catabolic process
A4R43_RS25920	COG0832	Belongs to the urease beta subunit family
A4R43_RS25925	COG0831	urea catabolic process
A4R43_RS25955	COG1131	(ABC) transporter
A4R43_RS25965	COG4585	Histidine kinase
A4R43_RS25970	COG2197	response regulator
A4R43_RS25985	COG5650	phosphatidylinositol metabolic process
A4R43_RS25995	COG1136	(ABC) transporter
A4R43_RS25995	COG0577	efflux transmembrane transporter activity
A4R43_RS26000	COG0577	efflux transmembrane transporter activity
A4R43_RS26000	COG1136	(ABC) transporter
A4R43_RS26015	COG0745	RESPONSE REGULATOR receiver
A4R43_RS26020	COG2205	protein histidine kinase activity
A4R43_RS26040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R43_RS26055	COG5398	heme oxygenase
A4R43_RS26065	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4R43_RS26075	COG2814	Major facilitator Superfamily
A4R43_RS26085	COG2252	PERMEase
A4R43_RS26100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS26120	COG2814	Major facilitator Superfamily
A4R43_RS26130	COG1278	Cold shock
A4R43_RS26150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_RS26155	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS26160	COG0384	phenazine biosynthesis protein PhzF
A4R43_RS26165	COG3304	Inner membrane component domain
A4R43_RS26180	COG2175	clavaminate synthase activity
A4R43_RS26230	COG2801	Transposase and inactivated derivatives
A4R43_RS26230	COG3415	Transposase
A4R43_RS26255	COG2018	Roadblock/LC7 domain
A4R43_RS26270	COG2018	Roadblock/LC7 domain
A4R43_RS26285	COG0765	amino acid transport
A4R43_RS26290	COG0765	amino acid transport
A4R43_RS26300	COG3142	Participates in the control of copper homeostasis
A4R43_RS26320	COG1061	Type III restriction enzyme res subunit
A4R43_RS26340	COG3629	intracellular signal transduction
A4R43_RS26340	COG3903	Transcriptional regulator
A4R43_RS26345	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS26365	COG0459	protein refolding
A4R43_RS26375	COG1278	Cold shock
A4R43_RS26395	COG0688	phosphatidylethanolamine metabolic process
A4R43_RS26405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R43_RS26420	COG0242	peptide deformylase activity
A4R43_RS26435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4R43_RS26440	COG0351	phosphomethylpyrimidine kinase
A4R43_RS26465	COG2022	thiamine diphosphate biosynthetic process
A4R43_RS26475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_RS26475	COG2022	thiamine diphosphate biosynthetic process
A4R43_RS26480	COG0352	thiamine-phosphate diphosphorylase activity
A4R43_RS26495	COG0477	Major facilitator Superfamily
A4R43_RS26500	COG2188	Transcriptional regulator
A4R43_RS26505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4R43_RS26510	COG2971	BadF BadG BcrA BcrD
A4R43_RS26520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4R43_RS26540	COG2885	chlorophyll binding
A4R43_RS26540	COG3047	cAMP biosynthetic process
A4R43_RS26560	COG3629	intracellular signal transduction
A4R43_RS26560	COG3903	Transcriptional regulator
A4R43_RS26565	COG5285	phytanoyl-CoA dioxygenase
A4R43_RS26570	COG1917	Cupin 2, conserved barrel domain protein
A4R43_RS26580	COG0456	acetyltransferase
A4R43_RS26590	COG4399	Belongs to the UPF0754 family
A4R43_RS26600	COG0400	carboxylic ester hydrolase activity
A4R43_RS26605	COG0346	lactoylglutathione lyase activity
A4R43_RS26640	COG0129	dihydroxy-acid dehydratase activity
A4R43_RS26665	COG0477	Major facilitator Superfamily
A4R43_RS26670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4R43_RS26675	COG2151	metal-sulfur cluster biosynthetic enzyme
A4R43_RS26680	COG3396	Phenylacetate-CoA oxygenase
A4R43_RS26685	COG3460	Phenylacetate-CoA oxygenase
A4R43_RS26690	COG3396	Phenylacetate-CoA oxygenase
A4R43_RS26695	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS26695	COG2030	dehydratase
A4R43_RS26705	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4R43_RS26720	COG1309	transcriptional regulator
A4R43_RS26740	COG1832	CoA-binding protein
A4R43_RS26770	COG2197	response regulator
A4R43_RS26790	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4R43_RS26790	COG1902	pentaerythritol trinitrate reductase activity
A4R43_RS26795	COG1695	Transcriptional regulator
A4R43_RS26800	COG0583	DNA-binding transcription factor activity
A4R43_RS26805	COG0384	phenazine biosynthesis protein PhzF
A4R43_RS26820	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4R43_RS26830	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A4R43_RS26870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4R43_RS26875	COG2847	Copper chaperone PCu(A)C
A4R43_RS26880	COG1329	Transcriptional regulator
A4R43_RS26900	COG0215	cysteine-tRNA ligase activity
A4R43_RS26955	COG4399	Belongs to the UPF0754 family
A4R43_RS26970	COG1120	ATPase activity
A4R43_RS26980	COG1609	Transcriptional regulator
A4R43_RS26990	COG1194	a g-specific adenine glycosylase
A4R43_RS27000	COG0596	Alpha beta hydrolase
A4R43_RS27065	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4R43_RS27070	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4R43_RS27095	COG0789	Transcriptional regulator
A4R43_RS27115	COG0302	gtp cyclohydrolase
A4R43_RS27120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R43_RS27150	COG0037	tRNA processing
A4R43_RS27160	COG2027	D-alanyl-D-alanine carboxypeptidase
A4R43_RS27170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4R43_RS27195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4R43_RS27205	COG0471	metal ion transport
A4R43_RS27215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4R43_RS27235	COG3550	peptidyl-serine autophosphorylation
A4R43_RS27250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4R43_RS27265	COG1754	DNA topoisomerase type I activity
A4R43_RS27265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4R43_RS27290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A4R43_RS27295	COG1205	dead DEAH box helicase
A4R43_RS27295	COG1111	helicase
A4R43_RS27350	COG1472	Belongs to the glycosyl hydrolase 3 family
A4R43_RS27355	COG3876	Protein conserved in bacteria
A4R43_RS27360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4R43_RS27365	COG1737	Transcriptional regulator
A4R43_RS27370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4R43_RS27380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A4R43_RS27390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_RS27430	COG3104	oligopeptide transport
A4R43_RS27435	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4R43_RS27445	COG0596	Alpha beta hydrolase
A4R43_RS27460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4R43_RS27530	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A4R43_RS27575	COG2226	methyltransferase
A4R43_RS27590	COG1764	response to oxidative stress
A4R43_RS27600	COG0657	acetylesterase activity
A4R43_RS27630	COG1690	Belongs to the RtcB family
A4R43_RS27670	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS27680	COG0583	DNA-binding transcription factor activity
A4R43_RS27690	COG0702	epimerase
A4R43_RS27695	COG4608	Belongs to the ABC transporter superfamily
A4R43_RS27700	COG0444	Belongs to the ABC transporter superfamily
A4R43_RS27705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R43_RS27710	COG0601	transmembrane transport
A4R43_RS27715	COG0747	negative chemotaxis
A4R43_RS27725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4R43_RS27730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4R43_RS27735	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R43_RS27740	COG1733	regulation of RNA biosynthetic process
A4R43_RS27745	COG3467	pyridoxamine 5'-phosphate
A4R43_RS27760	COG3540	Alkaline phosphatase
A4R43_RS27765	COG2205	protein histidine kinase activity
A4R43_RS27770	COG0745	RESPONSE REGULATOR receiver
A4R43_RS27780	COG2197	response regulator
A4R43_RS27820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4R43_RS27860	COG1739	Uncharacterized protein family UPF0029
A4R43_RS27885	COG0745	RESPONSE REGULATOR receiver
A4R43_RS27890	COG2205	protein histidine kinase activity
A4R43_RS27915	COG1674	ftsk spoiiie
A4R43_RS27960	COG1473	amidohydrolase
A4R43_RS27965	COG0287	Prephenate dehydrogenase
A4R43_RS27990	COG1131	(ABC) transporter
A4R43_RS27995	COG3559	Exporter of polyketide antibiotics
A4R43_RS28005	COG2010	Cytochrome c
A4R43_RS28005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4R43_RS28010	COG2080	2 iron, 2 sulfur cluster binding
A4R43_RS28025	COG2183	response to ionizing radiation
A4R43_RS28030	COG2197	response regulator
A4R43_RS28035	COG4585	Histidine kinase
A4R43_RS28075	COG0667	Aldo Keto reductase
A4R43_RS28155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_RS28175	COG0412	Dienelactone hydrolase
A4R43_RS28180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4R43_RS28200	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A4R43_RS28210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4R43_RS28230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4R43_RS28235	COG2197	response regulator
A4R43_RS28240	COG4585	Histidine kinase
A4R43_RS28255	COG0531	amino acid
A4R43_RS28295	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS28305	COG1672	PFAM Archaeal ATPase
A4R43_RS28305	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_RS28375	COG3321	synthase
A4R43_RS28375	COG0604	alcohol dehydrogenase
A4R43_RS28375	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS28410	COG1216	Glycosyl transferase, family 2
A4R43_RS28450	COG1216	Glycosyl transferase, family 2
A4R43_RS28460	COG0277	FAD linked oxidase domain protein
A4R43_RS28465	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS28490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4R43_RS28510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS28515	COG0561	phosphatase activity
A4R43_RS28560	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS28565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4R43_RS28585	COG0673	inositol 2-dehydrogenase activity
A4R43_RS28630	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS28640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_RS28670	COG0579	oxidoreductase
A4R43_RS28685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4R43_RS28690	COG0596	Alpha beta hydrolase
A4R43_RS28695	COG3766	membrane
A4R43_RS28700	COG0754	glutathionylspermidine amidase activity
A4R43_RS28750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4R43_RS28765	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4R43_RS28770	COG1072	(Pantothenic acid kinase))
A4R43_RS28780	COG4715	Zinc finger, swim domain protein
A4R43_RS28840	COG4988	ABC transporter
A4R43_RS28845	COG1294	oxidase, subunit
A4R43_RS28850	COG1271	oxidase subunit
A4R43_RS28915	COG1528	Iron-storage protein
A4R43_RS28925	COG1191	sigma factor activity
A4R43_RS28955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_RS28965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4R43_RS28990	COG3275	phosphorelay sensor kinase activity
A4R43_RS29000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4R43_RS29040	COG2234	aminopeptidase activity
A4R43_RS29045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4R43_RS29090	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS29110	COG2197	response regulator
A4R43_RS29115	COG4585	Histidine kinase
A4R43_RS29125	COG0477	Major facilitator Superfamily
A4R43_RS29160	COG0697	spore germination
A4R43_RS29165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4R43_RS29200	COG1174	glycine betaine transport
A4R43_RS29210	COG1174	glycine betaine transport
A4R43_RS29215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4R43_RS29265	COG2211	Major facilitator Superfamily
A4R43_RS29270	COG2723	6-phospho-beta-galactosidase activity
A4R43_RS29290	COG0702	epimerase
A4R43_RS29305	COG0515	serine threonine protein kinase
A4R43_RS29315	COG2301	Belongs to the HpcH HpaI aldolase family
A4R43_RS29330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS29340	COG0154	amidase activity
A4R43_RS29345	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS29350	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS29355	COG4608	Belongs to the ABC transporter superfamily
A4R43_RS29365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4R43_RS29375	COG0747	negative chemotaxis
A4R43_RS29420	COG1716	ATPase activity
A4R43_RS29425	COG1716	ATPase activity
A4R43_RS29440	COG0768	penicillin binding
A4R43_RS29445	COG0515	serine threonine protein kinase
A4R43_RS29450	COG2815	serine threonine protein kinase
A4R43_RS29450	COG0515	serine threonine protein kinase
A4R43_RS29465	COG3764	Sortase (surface protein transpeptidase)
A4R43_RS29600	COG3629	intracellular signal transduction
A4R43_RS29600	COG3903	Transcriptional regulator
A4R43_RS29625	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_RS29670	COG3118	belongs to the thioredoxin family
A4R43_RS29700	COG0484	heat shock protein binding
A4R43_RS29775	COG0443	Heat shock 70 kDa protein
A4R43_RS29780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4R43_RS29785	COG0484	heat shock protein binding
A4R43_RS29795	COG0542	response to heat
A4R43_RS29800	COG0501	Belongs to the peptidase M48B family
A4R43_RS29805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_RS29810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_RS29835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4R43_RS29855	COG0602	queuosine metabolic process
A4R43_RS29910	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS29920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4R43_RS29935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4R43_RS29945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4R43_RS29970	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4R43_RS30100	COG3328	transposase activity
A4R43_RS30115	COG1063	alcohol dehydrogenase
A4R43_RS30125	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS30135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_RS30135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4R43_RS30140	COG1024	Enoyl-CoA hydratase
A4R43_RS30150	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS30165	COG3284	Transcriptional regulator
A4R43_RS30175	COG1309	transcriptional regulator
A4R43_RS30215	COG2409	Drug exporters of the RND superfamily
A4R43_RS30305	COG0477	Major facilitator Superfamily
A4R43_RS30345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_RS30375	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS30395	COG3344	reverse transcriptase
A4R43_RS30410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4R43_RS30420	COG1024	Enoyl-CoA hydratase
A4R43_RS30430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS30445	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS30455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4R43_RS30460	COG0492	ferredoxin-NADP+ reductase activity
A4R43_RS30465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_RS30475	COG4191	Histidine kinase
A4R43_RS30480	COG2197	response regulator
A4R43_RS30490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4R43_RS30530	COG1127	ABC transporter
A4R43_RS30535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_RS30560	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS30595	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS30620	COG3328	transposase activity
A4R43_RS30790	COG0187	DNA topoisomerase II activity
A4R43_RS30795	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A4R43_RS30800	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4R43_RS30805	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A4R43_RS30810	COG0592	DNA-directed DNA polymerase activity
A4R43_RS30830	COG0594	ribonuclease P activity
A4R43_RS30835	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4R43_RS30840	COG0706	membrane insertase activity
A4R43_RS30850	COG0357	Ribosomal RNA small subunit methyltransferase G
A4R43_RS30855	COG1192	Involved in chromosome partitioning
A4R43_RS30865	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R43_RS30880	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4R43_RS30880	COG3409	Peptidoglycan-binding domain 1 protein
A4R43_RS30885	COG3118	belongs to the thioredoxin family
A4R43_RS30885	COG0492	ferredoxin-NADP+ reductase activity
A4R43_RS30900	COG1595	DNA-templated transcription, initiation
A4R43_RS30915	COG0765	amino acid transport
A4R43_RS30920	COG0765	amino acid transport
A4R43_RS30945	COG4585	Histidine kinase
A4R43_RS31005	COG1678	Uncharacterized ACR, COG1678
A4R43_RS31020	COG0495	leucyl-tRNA aminoacylation
A4R43_RS31045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_RS31055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4R43_RS31070	COG2197	response regulator
A4R43_RS31095	COG3384	dioxygenase
A4R43_RS31160	COG0359	binds to the 23S rRNA
A4R43_RS31165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4R43_RS31175	COG0360	Binds together with S18 to 16S ribosomal RNA
A4R43_RS31210	COG1940	carbohydrate kinase activity
A4R43_RS31215	COG0673	inositol 2-dehydrogenase activity
A4R43_RS31220	COG1228	amidohydrolase
A4R43_RS31225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4R43_RS31235	COG1695	Transcriptional regulator
A4R43_RS31250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R43_RS31255	COG2814	Major facilitator Superfamily
A4R43_RS31270	COG0842	Transport permease protein
A4R43_RS31290	COG4221	oxidoreductase activity
A4R43_RS31300	COG4585	Histidine kinase
A4R43_RS31305	COG2197	response regulator
A4R43_RS31310	COG0402	S-adenosylhomocysteine deaminase activity
A4R43_RS31315	COG2197	response regulator
A4R43_RS31325	COG1136	(ABC) transporter
A4R43_RS31335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4R43_RS31355	COG2197	response regulator
A4R43_RS31360	COG4585	Histidine kinase
A4R43_RS31380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4R43_RS31400	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A4R43_RS31405	COG4133	protoheme IX ABC transporter activity
A4R43_RS31460	COG0456	acetyltransferase
A4R43_RS31460	COG1846	Transcriptional regulator
A4R43_RS31470	COG0789	Transcriptional regulator
A4R43_RS31475	COG4552	Acetyltransferase involved in intracellular survival and related
A4R43_RS31480	COG0584	glycerophosphoryl diester phosphodiesterase
A4R43_RS31490	COG0183	Belongs to the thiolase family
A4R43_RS31495	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS31500	COG2030	dehydratase
A4R43_RS31505	COG1309	transcriptional regulator
A4R43_RS31520	COG3030	protein affecting phage T7 exclusion by the F plasmid
A4R43_RS31530	COG1132	(ABC) transporter
A4R43_RS31545	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_RS31550	COG0022	dehydrogenase e1 component
A4R43_RS31560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_RS31575	COG0765	amino acid transport
A4R43_RS31595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4R43_RS31600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4R43_RS31610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4R43_RS31630	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS31635	COG2197	response regulator
A4R43_RS31655	COG0737	Belongs to the 5'-nucleotidase family
A4R43_RS31670	COG1742	UPF0060 membrane protein
A4R43_RS31705	COG2340	Cysteine-rich secretory protein family
A4R43_RS31710	COG1024	Enoyl-CoA hydratase
A4R43_RS31715	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS31720	COG1309	transcriptional regulator
A4R43_RS31740	COG1522	sequence-specific DNA binding
A4R43_RS31760	COG0247	lactate metabolic process
A4R43_RS31760	COG2181	nitrate reductase activity
A4R43_RS31800	COG0443	Heat shock 70 kDa protein
A4R43_RS31805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4R43_RS31810	COG0484	heat shock protein binding
A4R43_RS31815	COG0789	Transcriptional regulator
A4R43_RS31835	COG0542	response to heat
A4R43_RS31845	COG0300	oxidoreductase activity
A4R43_RS31865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4R43_RS31870	COG0243	molybdopterin cofactor binding
A4R43_RS31885	COG1609	Transcriptional regulator
A4R43_RS31915	COG1072	(Pantothenic acid kinase))
A4R43_RS31920	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS31925	COG2188	Transcriptional regulator
A4R43_RS31930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_RS31940	COG0586	Pfam SNARE associated Golgi protein
A4R43_RS31945	COG2353	YceI-like domain
A4R43_RS31965	COG0477	Major facilitator Superfamily
A4R43_RS31985	COG0277	FAD linked oxidase domain protein
A4R43_RS31990	COG0586	Pfam SNARE associated Golgi protein
A4R43_RS32025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4R43_RS32065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4R43_RS32075	COG0584	glycerophosphoryl diester phosphodiesterase
A4R43_RS32120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4R43_RS32120	COG0515	serine threonine protein kinase
A4R43_RS32135	COG5280	Phage tail tape measure protein TP901
A4R43_RS32135	COG3953	SLT domain
A4R43_RS32145	COG0436	Aminotransferase
A4R43_RS32185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4R43_RS32195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_RS32200	COG0765	amino acid transport
A4R43_RS32205	COG1126	abc transporter atp-binding protein
A4R43_RS32215	COG0730	response to heat
A4R43_RS32255	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4R43_RS32260	COG0047	phosphoribosylformylglycinamidine synthase activity
A4R43_RS32265	COG1132	(ABC) transporter
A4R43_RS32270	COG1132	(ABC) transporter
A4R43_RS32345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4R43_RS32350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4R43_RS32360	COG4565	transcriptional regulatory protein
A4R43_RS32365	COG3290	protein histidine kinase activity
A4R43_RS32405	COG3845	ABC transporter
A4R43_RS32445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4R43_RS32455	COG1984	allophanate hydrolase subunit 2
A4R43_RS32460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4R43_RS32465	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A4R43_RS32485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4R43_RS32495	COG0745	RESPONSE REGULATOR receiver
A4R43_RS32500	COG0456	acetyltransferase
A4R43_RS32500	COG0454	-acetyltransferase
A4R43_RS32520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4R43_RS32540	COG2508	Transcriptional regulator
A4R43_RS32540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4R43_RS32545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4R43_RS32565	COG1309	transcriptional regulator
A4R43_RS32590	COG2272	Belongs to the type-B carboxylesterase lipase family
A4R43_RS32615	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS32645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4R43_RS32675	COG0604	alcohol dehydrogenase
A4R43_RS32675	COG3321	synthase
A4R43_RS32690	COG1316	TRANSCRIPTIONal
A4R43_RS32710	COG0204	Acyl-transferase
A4R43_RS32710	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS32755	COG0443	Heat shock 70 kDa protein
A4R43_RS32795	COG0515	serine threonine protein kinase
A4R43_RS32805	COG1132	(ABC) transporter
A4R43_RS32810	COG1132	(ABC) transporter
A4R43_RS32845	COG4585	Histidine kinase
A4R43_RS32850	COG2197	response regulator
A4R43_RS32860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_RS32865	COG1414	Transcriptional regulator
A4R43_RS32870	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS32875	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS32885	COG0515	serine threonine protein kinase
A4R43_RS32890	COG1408	metallophosphoesterase
A4R43_RS32910	COG1595	DNA-templated transcription, initiation
A4R43_RS32925	COG1278	Cold shock
A4R43_RS32955	COG0114	fumarate hydratase activity
A4R43_RS33025	COG2364	Membrane
A4R43_RS33030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS33050	COG2733	membrane
A4R43_RS33060	COG3795	YCII-related domain
A4R43_RS33065	COG4941	Belongs to the sigma-70 factor family
A4R43_RS33085	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4R43_RS33085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4R43_RS33090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4R43_RS33120	COG2130	NADP-dependent
A4R43_RS33130	COG0788	formyltetrahydrofolate deformylase activity
A4R43_RS33150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4R43_RS33165	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS33200	COG0667	Aldo Keto reductase
A4R43_RS33205	COG5002	protein histidine kinase activity
A4R43_RS33230	COG0506	proline dehydrogenase activity
A4R43_RS33240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4R43_RS33285	COG1595	DNA-templated transcription, initiation
A4R43_RS33290	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS33330	COG3903	Transcriptional regulator
A4R43_RS33330	COG3629	intracellular signal transduction
A4R43_RS33335	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4R43_RS33340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4R43_RS33345	COG0181	hydroxymethylbilane synthase activity
A4R43_RS33350	COG1648	precorrin-2 dehydrogenase activity
A4R43_RS33350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4R43_RS33375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4R43_RS33380	COG0406	alpha-ribazole phosphatase activity
A4R43_RS33400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4R43_RS33420	COG1522	sequence-specific DNA binding
A4R43_RS33455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4R43_RS33460	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4R43_RS33475	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_RS33485	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS33490	COG2226	methyltransferase
A4R43_RS33505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R43_RS33510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R43_RS33515	COG0649	NAD binding
A4R43_RS33530	COG1034	ATP synthesis coupled electron transport
A4R43_RS33535	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A4R43_RS33540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4R43_RS33545	COG0839	Belongs to the complex I subunit 6 family
A4R43_RS33550	COG0713	ATP synthesis coupled electron transport
A4R43_RS33565	COG1007	ATP synthesis coupled electron transport
A4R43_RS33645	COG0142	geranyltranstransferase activity
A4R43_RS33655	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4R43_RS33660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4R43_RS33660	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4R43_RS33670	COG1522	sequence-specific DNA binding
A4R43_RS33675	COG1834	amidinotransferase
A4R43_RS33680	COG1215	transferase activity, transferring glycosyl groups
A4R43_RS33755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_RS33770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_RS33775	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS33790	COG0673	inositol 2-dehydrogenase activity
A4R43_RS33810	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4R43_RS33815	COG0596	Alpha beta hydrolase
A4R43_RS33820	COG1309	transcriptional regulator
A4R43_RS33830	COG1666	GTP binding
A4R43_RS33890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4R43_RS33895	COG2197	response regulator
A4R43_RS33900	COG4585	Histidine kinase
A4R43_RS33905	COG0586	Pfam SNARE associated Golgi protein
A4R43_RS33910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4R43_RS33940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4R43_RS33950	COG2030	dehydratase
A4R43_RS33970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4R43_RS33980	COG0436	Aminotransferase
A4R43_RS34005	COG0081	regulation of translation
A4R43_RS34020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4R43_RS34025	COG0222	ribosome binding
A4R43_RS34040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4R43_RS34095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4R43_RS34100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4R43_RS34120	COG4585	Histidine kinase
A4R43_RS34125	COG2197	response regulator
A4R43_RS34130	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A4R43_RS34185	COG1940	carbohydrate kinase activity
A4R43_RS34195	COG1129	ABC transporter
A4R43_RS34200	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS34210	COG0673	inositol 2-dehydrogenase activity
A4R43_RS34215	COG3507	Belongs to the glycosyl hydrolase 43 family
A4R43_RS34225	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4R43_RS34235	COG0084	hydrolase, TatD family'
A4R43_RS34265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4R43_RS34270	COG0049	tRNA binding
A4R43_RS34275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4R43_RS34285	COG0051	transcription antitermination factor activity, RNA binding
A4R43_RS34290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4R43_RS34295	COG0088	Forms part of the polypeptide exit tunnel
A4R43_RS34300	COG0089	rRNA binding
A4R43_RS34305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4R43_RS34310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4R43_RS34315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4R43_RS34320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4R43_RS34325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4R43_RS34330	COG0255	Belongs to the universal ribosomal protein uL29 family
A4R43_RS34335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4R43_RS34340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4R43_RS34345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4R43_RS34350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4R43_RS34360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4R43_RS34365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4R43_RS34370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4R43_RS34375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4R43_RS34380	COG1841	ribosomal large subunit assembly
A4R43_RS34385	COG0200	Binds to the 23S rRNA
A4R43_RS34395	COG1280	lysine exporter protein (LysE YggA)
A4R43_RS34405	COG0563	adenylate kinase activity
A4R43_RS34415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4R43_RS34420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4R43_RS34435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4R43_RS34440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4R43_RS34445	COG0202	RNA polymerase activity
A4R43_RS34450	COG0203	ribosomal protein L17
A4R43_RS34455	COG0101	tRNA pseudouridine synthase activity
A4R43_RS34495	COG1404	Belongs to the peptidase S8 family
A4R43_RS34505	COG1674	ftsk spoiiie
A4R43_RS34510	COG0443	Heat shock 70 kDa protein
A4R43_RS34550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4R43_RS34555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4R43_RS34560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4R43_RS34580	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS34615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4R43_RS34635	COG0395	ABC-type sugar transport system, permease component
A4R43_RS34640	COG1063	alcohol dehydrogenase
A4R43_RS34645	COG1349	DNA-binding transcription factor activity
A4R43_RS34650	COG1063	alcohol dehydrogenase
A4R43_RS34655	COG1070	Carbohydrate kinase
A4R43_RS34660	COG3842	ATPase activity
A4R43_RS34665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4R43_RS34675	COG0802	atpase or kinase
A4R43_RS34680	COG3458	cephalosporin-C deacetylase activity
A4R43_RS34685	COG0154	amidase activity
A4R43_RS34690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4R43_RS34690	COG0825	malonyl-CoA metabolic process
A4R43_RS34695	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS34705	COG2186	Transcriptional regulator
A4R43_RS34710	COG3209	COG3209 Rhs family protein
A4R43_RS34730	COG0456	acetyltransferase
A4R43_RS34735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4R43_RS34745	COG3540	Alkaline phosphatase
A4R43_RS34750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4R43_RS34755	COG0459	protein refolding
A4R43_RS34760	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS34765	COG1309	transcriptional regulator
A4R43_RS34810	COG0516	GMP reductase activity
A4R43_RS34830	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS34835	COG0519	Catalyzes the synthesis of GMP from XMP
A4R43_RS34835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4R43_RS34865	COG0583	DNA-binding transcription factor activity
A4R43_RS34870	COG2815	serine threonine protein kinase
A4R43_RS34870	COG0515	serine threonine protein kinase
A4R43_RS34875	COG0515	serine threonine protein kinase
A4R43_RS34925	COG0045	succinate-CoA ligase (ADP-forming) activity
A4R43_RS34950	COG0138	bifunctional purine biosynthesis protein purh
A4R43_RS34990	COG0587	DNA-directed DNA polymerase activity
A4R43_RS35010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4R43_RS35020	COG2814	Major facilitator Superfamily
A4R43_RS35025	COG0640	Transcriptional regulator
A4R43_RS35030	COG2814	Major facilitator Superfamily
A4R43_RS35070	COG0708	Exodeoxyribonuclease III
A4R43_RS35075	COG3415	Transposase
A4R43_RS35075	COG2801	Transposase and inactivated derivatives
A4R43_RS35095	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A4R43_RS35110	COG0180	Tryptophanyl-tRNA synthetase
A4R43_RS35135	COG1295	ribonuclease BN
A4R43_RS35140	COG2814	Major facilitator Superfamily
A4R43_RS35145	COG1686	Belongs to the peptidase S11 family
A4R43_RS35190	COG1609	Transcriptional regulator
A4R43_RS35200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4R43_RS35215	COG2009	succinate dehydrogenase
A4R43_RS35220	COG1744	ABC transporter substrate-binding protein PnrA-like
A4R43_RS35225	COG3845	ABC transporter
A4R43_RS35230	COG4603	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS35235	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS35255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4R43_RS35260	COG2271	Major facilitator Superfamily
A4R43_RS35305	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS35310	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS35315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4R43_RS35365	COG0667	Aldo Keto reductase
A4R43_RS35370	COG0667	Aldo Keto reductase
A4R43_RS35380	COG0477	Major facilitator Superfamily
A4R43_RS35410	COG0706	membrane insertase activity
A4R43_RS35415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4R43_RS35430	COG0515	serine threonine protein kinase
A4R43_RS35455	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
A4R43_RS35455	COG1473	amidohydrolase
A4R43_RS35480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4R43_RS35485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4R43_RS35490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4R43_RS35495	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS35505	COG2197	response regulator
A4R43_RS35510	COG3851	Histidine kinase
A4R43_RS35520	COG4770	biotin carboxylase activity
A4R43_RS35525	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A4R43_RS35530	COG0235	Class ii aldolase
A4R43_RS35535	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
A4R43_RS35540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A4R43_RS35550	COG0813	purine-nucleoside phosphorylase activity
A4R43_RS35555	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS35560	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS35565	COG3845	ABC transporter
A4R43_RS35585	COG1301	dicarboxylic acid transport
A4R43_RS35590	COG0424	maF-like protein
A4R43_RS35605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_RS35625	COG0596	Alpha beta hydrolase
A4R43_RS35645	COG1725	Transcriptional regulator
A4R43_RS35680	COG0791	NLP P60 protein
A4R43_RS35680	COG3103	Sh3 type 3 domain protein
A4R43_RS35680	COG1388	LysM domain
A4R43_RS35685	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4R43_RS35685	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4R43_RS35725	COG0483	inositol monophosphate 1-phosphatase activity
A4R43_RS35730	COG0745	RESPONSE REGULATOR receiver
A4R43_RS35735	COG2205	protein histidine kinase activity
A4R43_RS35785	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS35790	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS35805	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4R43_RS35810	COG2814	Major facilitator Superfamily
A4R43_RS35815	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS35825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_RS35830	COG5479	isomerase activity
A4R43_RS35830	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A4R43_RS35840	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4R43_RS35865	COG2259	Doxx family
A4R43_RS35875	COG1316	TRANSCRIPTIONal
A4R43_RS35880	COG1316	TRANSCRIPTIONal
A4R43_RS35910	COG0438	transferase activity, transferring glycosyl groups
A4R43_RS35945	COG1725	Transcriptional regulator
A4R43_RS35965	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A4R43_RS35965	COG0778	Nitroreductase
A4R43_RS35970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4R43_RS36025	COG1611	Belongs to the LOG family
A4R43_RS36040	COG0463	Glycosyl transferase, family 2
A4R43_RS36050	COG4988	ABC transporter
A4R43_RS36055	COG1294	oxidase, subunit
A4R43_RS36060	COG1271	oxidase subunit
A4R43_RS36085	COG0519	Catalyzes the synthesis of GMP from XMP
A4R43_RS36095	COG1024	Enoyl-CoA hydratase
A4R43_RS36105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4R43_RS36110	COG0583	DNA-binding transcription factor activity
A4R43_RS36115	COG2814	Major facilitator Superfamily
A4R43_RS36120	COG4122	O-methyltransferase activity
A4R43_RS36135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4R43_RS36140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4R43_RS36155	COG2239	Acts as a magnesium transporter
A4R43_RS36160	COG0330	HflC and HflK could
A4R43_RS36210	COG1309	transcriptional regulator
A4R43_RS36240	COG0598	Magnesium transport protein CorA
A4R43_RS36275	COG0613	PHP domain protein
A4R43_RS36280	COG2095	MarC family integral membrane protein
A4R43_RS36305	COG0513	Belongs to the DEAD box helicase family
A4R43_RS36340	COG2267	carboxylic ester hydrolase activity
A4R43_RS36350	COG0596	Alpha beta hydrolase
A4R43_RS36370	COG0243	molybdopterin cofactor binding
A4R43_RS36375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_RS36385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_RS36385	COG2146	nitrite reductase [NAD(P)H] activity
A4R43_RS36390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_RS36390	COG2146	nitrite reductase [NAD(P)H] activity
A4R43_RS36415	COG2378	regulation of single-species biofilm formation
A4R43_RS36435	COG0210	DNA helicase
A4R43_RS36475	COG0714	Associated with various cellular activities
A4R43_RS36510	COG0612	Peptidase, M16
A4R43_RS36570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A4R43_RS36575	COG3265	gluconokinase activity
A4R43_RS36580	COG2197	response regulator
A4R43_RS36605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_RS36675	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A4R43_RS36685	COG1012	belongs to the aldehyde dehydrogenase family
A4R43_RS36705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4R43_RS36710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A4R43_RS36710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4R43_RS36720	COG2318	DinB family
A4R43_RS36725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4R43_RS36730	COG3830	Belongs to the UPF0237 family
A4R43_RS36730	COG0560	Phosphoserine phosphatase
A4R43_RS36775	COG1335	isochorismatase
A4R43_RS36780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4R43_RS36785	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A4R43_RS36795	COG3191	aminopeptidase activity
A4R43_RS36815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4R43_RS36820	COG0705	Rhomboid family
A4R43_RS36835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4R43_RS36840	COG1234	tRNA 3'-trailer cleavage
A4R43_RS36850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A4R43_RS36855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4R43_RS36880	COG1733	regulation of RNA biosynthetic process
A4R43_RS36930	COG0243	molybdopterin cofactor binding
A4R43_RS36960	COG2261	transglycosylase associated protein
A4R43_RS36980	COG0587	DNA-directed DNA polymerase activity
A4R43_RS36985	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4R43_RS36990	COG1309	transcriptional regulator
A4R43_RS37000	COG2124	cytochrome p450
A4R43_RS37005	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
A4R43_RS37035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4R43_RS37040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4R43_RS37050	COG1609	Transcriptional regulator
A4R43_RS37055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4R43_RS37065	COG2223	nitrite transmembrane transporter activity
A4R43_RS37290	COG1309	transcriptional regulator
A4R43_RS37295	COG2272	Belongs to the type-B carboxylesterase lipase family
A4R43_RS37305	COG1295	ribonuclease BN
A4R43_RS37325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4R43_RS37335	COG1733	regulation of RNA biosynthetic process
A4R43_RS37340	COG1070	Carbohydrate kinase
A4R43_RS37345	COG2814	Major facilitator Superfamily
A4R43_RS37350	COG1349	DNA-binding transcription factor activity
A4R43_RS37355	COG0588	phosphoglycerate mutase activity
A4R43_RS37360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4R43_RS37365	COG2376	Dihydroxyacetone kinase
A4R43_RS37370	COG0698	ribose 5-phosphate isomerase
A4R43_RS37375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4R43_RS37385	COG0235	Class ii aldolase
A4R43_RS37390	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS37395	COG0640	Transcriptional regulator
A4R43_RS37455	COG5002	protein histidine kinase activity
A4R43_RS37470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4R43_RS37480	COG0367	asparagine synthase
A4R43_RS37485	COG1045	serine acetyltransferase
A4R43_RS37490	COG1733	regulation of RNA biosynthetic process
A4R43_RS37495	COG3629	intracellular signal transduction
A4R43_RS37510	COG4585	Histidine kinase
A4R43_RS37520	COG2197	response regulator
A4R43_RS37530	COG1917	Cupin 2, conserved barrel domain protein
A4R43_RS37530	COG4977	sequence-specific DNA binding
A4R43_RS37555	COG2124	cytochrome p450
A4R43_RS37590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_RS37610	COG0477	Major facilitator Superfamily
A4R43_RS37620	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS37625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_RS37680	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS37685	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS37690	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS37695	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS37705	COG1794	racemase activity, acting on amino acids and derivatives
A4R43_RS37720	COG0367	asparagine synthase
A4R43_RS37800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4R43_RS37815	COG1846	Transcriptional regulator
A4R43_RS37870	COG3012	SEC-C Motif Domain Protein
A4R43_RS37880	COG0515	serine threonine protein kinase
A4R43_RS37905	COG0187	DNA topoisomerase II activity
A4R43_RS37910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4R43_RS37925	COG0583	DNA-binding transcription factor activity
A4R43_RS37945	COG0175	sulfate reduction
A4R43_RS37955	COG0745	RESPONSE REGULATOR receiver
A4R43_RS37965	COG3903	Transcriptional regulator
A4R43_RS37965	COG3629	intracellular signal transduction
A4R43_RS37975	COG2205	protein histidine kinase activity
A4R43_RS37985	COG0714	Associated with various cellular activities
A4R43_RS38025	COG3831	ATPase activity
A4R43_RS38030	COG0714	Associated with various cellular activities
A4R43_RS38035	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A4R43_RS38040	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A4R43_RS38045	COG4715	Zinc finger, swim domain protein
A4R43_RS38070	COG1522	sequence-specific DNA binding
A4R43_RS38085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4R43_RS38090	COG3629	intracellular signal transduction
A4R43_RS38090	COG3903	Transcriptional regulator
A4R43_RS38105	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_RS38125	COG0745	RESPONSE REGULATOR receiver
A4R43_RS38130	COG2205	protein histidine kinase activity
A4R43_RS38145	COG1136	(ABC) transporter
A4R43_RS38150	COG0577	efflux transmembrane transporter activity
A4R43_RS38205	COG0604	alcohol dehydrogenase
A4R43_RS38205	COG3321	synthase
A4R43_RS38285	COG0300	oxidoreductase activity
A4R43_RS38310	COG4991	sh3 domain protein
A4R43_RS38315	COG3629	intracellular signal transduction
A4R43_RS38315	COG3903	Transcriptional regulator
A4R43_RS38320	COG4991	sh3 domain protein
A4R43_RS38325	COG3540	Alkaline phosphatase
A4R43_RS38330	COG1278	Cold shock
A4R43_RS38345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4R43_RS38350	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A4R43_RS38365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A4R43_RS38370	COG1132	(ABC) transporter
A4R43_RS38380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS38385	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS38400	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS38410	COG0067	glutamate synthase
A4R43_RS38410	COG0069	glutamate synthase activity
A4R43_RS38410	COG0070	glutamate synthase
A4R43_RS38420	COG0247	lactate metabolic process
A4R43_RS38420	COG0277	FAD linked oxidase domain protein
A4R43_RS38435	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A4R43_RS38435	COG0235	Class ii aldolase
A4R43_RS38440	COG0471	metal ion transport
A4R43_RS38445	COG0583	DNA-binding transcription factor activity
A4R43_RS38460	COG1960	acyl-CoA dehydrogenase activity
A4R43_RS38470	COG1024	Enoyl-CoA hydratase
A4R43_RS38475	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS38505	COG3483	tryptophan 2,3-dioxygenase activity
A4R43_RS38540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4R43_RS38540	COG2226	methyltransferase
A4R43_RS38540	COG0596	Alpha beta hydrolase
A4R43_RS38565	COG0583	DNA-binding transcription factor activity
A4R43_RS38570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4R43_RS38590	COG2072	flavoprotein involved in K transport
A4R43_RS38625	COG1175	transmembrane transport
A4R43_RS38630	COG0395	ABC-type sugar transport system, permease component
A4R43_RS38635	COG0366	Alpha amylase catalytic
A4R43_RS38645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4R43_RS38645	COG1796	DNA polymerase
A4R43_RS38655	COG3268	Saccharopine dehydrogenase
A4R43_RS38675	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_RS38680	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS38685	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS38695	COG1129	ABC transporter
A4R43_RS38700	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS38705	COG2186	Transcriptional regulator
A4R43_RS38725	COG2197	response regulator
A4R43_RS38770	COG0246	Mannitol dehydrogenase
A4R43_RS38820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4R43_RS38825	COG0531	amino acid
A4R43_RS38860	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_RS38860	COG1672	PFAM Archaeal ATPase
A4R43_RS38870	COG0667	Aldo Keto reductase
A4R43_RS38875	COG0583	DNA-binding transcription factor activity
A4R43_RS38895	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS38900	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS38905	COG0656	L-ascorbic acid biosynthetic process
A4R43_RS38910	COG2814	Major facilitator Superfamily
A4R43_RS38920	COG1793	dna ligase
A4R43_RS38935	COG0596	Alpha beta hydrolase
A4R43_RS38945	COG0477	Major facilitator Superfamily
A4R43_RS38980	COG3321	synthase
A4R43_RS38980	COG0604	alcohol dehydrogenase
A4R43_RS38980	COG3321	synthase
A4R43_RS38980	COG0604	alcohol dehydrogenase
A4R43_RS39000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4R43_RS39015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS39105	COG3321	synthase
A4R43_RS39105	COG0604	alcohol dehydrogenase
A4R43_RS39110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4R43_RS39150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4R43_RS39155	COG3467	pyridoxamine 5'-phosphate
A4R43_RS39160	COG0326	Molecular chaperone. Has ATPase activity
A4R43_RS39190	COG2197	response regulator
A4R43_RS39215	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS39235	COG0492	ferredoxin-NADP+ reductase activity
A4R43_RS39240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4R43_RS39255	COG0640	Transcriptional regulator
A4R43_RS39295	COG1846	Transcriptional regulator
A4R43_RS39305	COG5006	permease, DMT superfamily
A4R43_RS39320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4R43_RS39335	COG1695	Transcriptional regulator
A4R43_RS39380	COG2223	nitrite transmembrane transporter activity
A4R43_RS39395	COG0629	single-stranded DNA binding
A4R43_RS39410	COG2902	Dehydrogenase
A4R43_RS39440	COG0366	Alpha amylase catalytic
A4R43_RS39450	COG0668	transmembrane transport
A4R43_RS39470	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4R43_RS39480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4R43_RS39485	COG0477	Major facilitator Superfamily
A4R43_RS39495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_RS39525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4R43_RS39635	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4R43_RS39645	COG0740	serine-type endopeptidase activity
A4R43_RS39650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4R43_RS39670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4R43_RS39705	COG0525	valine-tRNA ligase activity
A4R43_RS39725	COG2755	lipolytic protein G-D-S-L family
A4R43_RS39735	COG1129	ABC transporter
A4R43_RS39740	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4R43_RS39755	COG1082	Xylose isomerase domain protein TIM barrel
A4R43_RS39780	COG0285	dihydrofolate synthase activity
A4R43_RS39790	COG2366	antibiotic biosynthetic process
A4R43_RS39800	COG0105	UTP biosynthetic process
A4R43_RS39810	COG2186	Transcriptional regulator
A4R43_RS39825	COG1131	(ABC) transporter
A4R43_RS39835	COG0842	Transport permease protein
A4R43_RS39845	COG1530	ribonuclease E activity
A4R43_RS39845	COG1530	ribonuclease E activity
A4R43_RS39850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4R43_RS39855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4R43_RS39860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4R43_RS39885	COG0577	efflux transmembrane transporter activity
A4R43_RS39885	COG1136	(ABC) transporter
A4R43_RS39895	COG1309	transcriptional regulator
A4R43_RS39900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS39905	COG0477	Major facilitator Superfamily
A4R43_RS39910	COG0514	ATP-dependent DNA helicase (RecQ)
A4R43_RS39910	COG0514	ATP-dependent DNA helicase (RecQ)
A4R43_RS39915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4R43_RS39920	COG0799	negative regulation of ribosome biogenesis
A4R43_RS39925	COG0406	alpha-ribazole phosphatase activity
A4R43_RS39935	COG1307	EDD domain protein, DegV family
A4R43_RS39960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4R43_RS39965	COG1555	photosystem II stabilization
A4R43_RS39965	COG1596	polysaccharide export
A4R43_RS39985	COG0268	Binds directly to 16S ribosomal RNA
A4R43_RS40025	COG0481	GTPase activity
A4R43_RS40045	COG2070	2-Nitropropane dioxygenase
A4R43_RS40050	COG0531	amino acid
A4R43_RS40055	COG2267	carboxylic ester hydrolase activity
A4R43_RS40060	COG0604	alcohol dehydrogenase
A4R43_RS40070	COG4290	ribonuclease
A4R43_RS40075	COG2732	(Barnase) inhibitor
A4R43_RS40080	COG1024	Enoyl-CoA hydratase
A4R43_RS40125	COG2197	response regulator
A4R43_RS40130	COG4585	Histidine kinase
A4R43_RS40135	COG2409	Drug exporters of the RND superfamily
A4R43_RS40150	COG2226	methyltransferase
A4R43_RS40165	COG0640	Transcriptional regulator
A4R43_RS40200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4R43_RS40210	COG1953	Uracil, thiamine, allantoin
A4R43_RS40225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4R43_RS40235	COG1420	regulation of RNA biosynthetic process
A4R43_RS40240	COG0484	heat shock protein binding
A4R43_RS40250	COG0537	adenosine 5'-monophosphoramidase activity
A4R43_RS40260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4R43_RS40275	COG3629	intracellular signal transduction
A4R43_RS40275	COG3903	Transcriptional regulator
A4R43_RS40280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4R43_RS40305	COG1381	Involved in DNA repair and RecF pathway recombination
A4R43_RS40310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4R43_RS40320	COG0701	Predicted permease
A4R43_RS40360	COG0423	glycine-tRNA ligase activity
A4R43_RS40365	COG1131	(ABC) transporter
A4R43_RS40375	COG4585	Histidine kinase
A4R43_RS40385	COG2197	response regulator
A4R43_RS40420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4R43_RS40425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_RS40430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4R43_RS40435	COG1595	DNA-templated transcription, initiation
A4R43_RS40450	COG4106	trans-aconitate 2-methyltransferase activity
A4R43_RS40465	COG1078	dGTPase activity
A4R43_RS40480	COG2815	serine threonine protein kinase
A4R43_RS40480	COG0515	serine threonine protein kinase
A4R43_RS40505	COG3209	COG3209 Rhs family protein
A4R43_RS40515	COG0583	DNA-binding transcription factor activity
A4R43_RS40520	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4R43_RS40530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS40560	COG3903	Transcriptional regulator
A4R43_RS40560	COG3629	intracellular signal transduction
A4R43_RS40575	COG0574	Belongs to the PEP-utilizing enzyme family
A4R43_RS40575	COG3848	Pyruvate phosphate dikinase
A4R43_RS40580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4R43_RS40605	COG1414	Transcriptional regulator
A4R43_RS40615	COG0800	Aldolase
A4R43_RS40620	COG4948	Mandelate Racemase Muconate Lactonizing
A4R43_RS40625	COG2271	Major facilitator Superfamily
A4R43_RS40665	COG1028	Short-chain dehydrogenase reductase Sdr
A4R43_RS40680	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A4R43_RS40725	COG0137	argininosuccinate synthase activity
A4R43_RS40735	COG1309	transcriptional regulator
A4R43_RS40765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS40770	COG1802	Transcriptional regulator
A4R43_RS40800	COG2072	flavoprotein involved in K transport
A4R43_RS40830	COG0477	Major facilitator Superfamily
A4R43_RS40845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4R43_RS40860	COG4941	Belongs to the sigma-70 factor family
A4R43_RS40885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS40890	COG1120	ATPase activity
A4R43_RS40910	COG2826	transposase and inactivated derivatives, IS30 family
A4R43_RS40935	COG4106	trans-aconitate 2-methyltransferase activity
A4R43_RS40940	COG1309	transcriptional regulator
A4R43_RS40965	COG0778	Nitroreductase
A4R43_RS40965	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
A4R43_RS41040	COG1454	alcohol dehydrogenase
A4R43_RS41145	COG0395	ABC-type sugar transport system, permease component
A4R43_RS41195	COG2072	flavoprotein involved in K transport
A4R43_RS41215	COG0583	DNA-binding transcription factor activity
A4R43_RS41275	COG1793	dna ligase
A4R43_RS41275	COG3285	dna ligase
A4R43_RS41295	COG0367	asparagine synthase
A4R43_RS41310	COG1940	carbohydrate kinase activity
A4R43_RS41315	COG2115	Belongs to the xylose isomerase family
A4R43_RS41360	COG0328	RNA-DNA hybrid ribonuclease activity
A4R43_RS41370	COG0318	PFAM AMP-dependent synthetase and ligase
A4R43_RS41375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4R43_RS41385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4R43_RS41390	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A4R43_RS41420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4R43_RS41475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4R43_RS41480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4R43_RS41500	COG0626	cystathionine gamma-synthase activity
A4R43_RS41530	COG1410	methionine synthase
A4R43_RS41530	COG0646	methionine synthase
A4R43_RS41535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4R43_RS41545	COG2022	thiamine diphosphate biosynthetic process
A4R43_RS41565	COG0667	Aldo Keto reductase
A4R43_RS41585	COG0702	epimerase
A4R43_RS41590	COG1733	regulation of RNA biosynthetic process
A4R43_RS41600	COG2197	response regulator
A4R43_RS41625	COG4942	peptidase
A4R43_RS41635	COG3226	Transcriptional regulator
A4R43_RS41650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4R43_RS41665	COG0779	Required for maturation of 30S ribosomal subunits
A4R43_RS41680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4R43_RS41690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4R43_RS41710	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4R43_RS41750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4R43_RS41770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4R43_RS41775	COG1185	polyribonucleotide nucleotidyltransferase activity
A4R43_RS41780	COG0612	Peptidase, M16
A4R43_RS41785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4R43_RS41810	COG3214	Protein conserved in bacteria
A4R43_RS41815	COG0477	Major facilitator Superfamily
A4R43_RS41825	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
A4R43_RS41825	COG1672	PFAM Archaeal ATPase
A4R43_RS41855	COG2815	serine threonine protein kinase
A4R43_RS41855	COG0515	serine threonine protein kinase
A4R43_RS41860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4R43_RS41865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4R43_RS41890	COG1674	ftsk spoiiie
A4R43_RS41910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4R43_RS41915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4R43_RS41925	COG1546	Belongs to the CinA family
A4R43_RS41925	COG1058	Belongs to the CinA family
A4R43_RS41930	COG1396	sequence-specific DNA binding
A4R43_RS41935	COG1842	Phage shock protein A
A4R43_RS41950	COG0167	dihydroorotate dehydrogenase activity
A4R43_RS41960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4R43_RS41965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4R43_RS41970	COG0489	protein tyrosine kinase activity
A4R43_RS41970	COG2151	metal-sulfur cluster biosynthetic enzyme
A4R43_RS41980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4R43_RS41990	COG1305	Transglutaminase-like
A4R43_RS42000	COG0714	Associated with various cellular activities
A4R43_RS42025	COG2001	Belongs to the MraZ family
A4R43_RS42030	COG0275	rRNA processing
A4R43_RS42040	COG0768	penicillin binding
A4R43_RS42055	COG0248	Ppx GppA phosphatase
A4R43_RS42105	COG1476	TRANSCRIPTIONal
A4R43_RS42115	COG1131	(ABC) transporter
A4R43_RS42120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4R43_RS42170	COG1797	cobyrinic acid a,c-diamide synthase activity
A4R43_RS42180	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A4R43_RS42195	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A4R43_RS42200	COG1492	cobalamin metabolic process
A4R43_RS42225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4R43_RS42250	COG1522	sequence-specific DNA binding
A4R43_RS42265	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4R43_RS42275	COG1309	transcriptional regulator
A4R43_RS42285	COG2226	methyltransferase
A4R43_RS42290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4R43_RS42305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4R43_RS42320	COG1132	(ABC) transporter
A4R43_RS42325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4R43_RS42340	COG3537	Alpha-1,2-mannosidase
A4R43_RS42350	COG0514	ATP-dependent DNA helicase (RecQ)
A4R43_RS42365	COG4221	oxidoreductase activity
A4R43_RS42370	COG3199	ATP-NAD kinase
A4R43_RS42375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4R43_RS42390	COG1063	alcohol dehydrogenase
A4R43_RS42450	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4R43_RS42455	COG2318	DinB family