locus-tag	class	description
AMETH_RS00020	COG0592	DNA-directed DNA polymerase activity
AMETH_RS00025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AMETH_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AMETH_RS00035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AMETH_RS00040	COG0187	DNA topoisomerase II activity
AMETH_RS00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMETH_RS00140	COG0494	nUDIX hydrolase
AMETH_RS00155	COG2353	YceI-like domain
AMETH_RS00230	COG0705	Rhomboid family
AMETH_RS00230	COG0457	Tetratricopeptide repeat
AMETH_RS00245	COG3764	Sortase (surface protein transpeptidase)
AMETH_RS00275	COG0515	serine threonine protein kinase
AMETH_RS00280	COG0768	penicillin binding
AMETH_RS00295	COG1716	ATPase activity
AMETH_RS00300	COG1716	ATPase activity
AMETH_RS00330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMETH_RS00375	COG2226	methyltransferase
AMETH_RS00380	COG2186	Transcriptional regulator
AMETH_RS00385	COG0747	negative chemotaxis
AMETH_RS00395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_RS00405	COG4608	Belongs to the ABC transporter superfamily
AMETH_RS00410	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS00415	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS00420	COG0154	amidase activity
AMETH_RS00435	COG2301	Belongs to the HpcH HpaI aldolase family
AMETH_RS00490	COG2211	Major facilitator Superfamily
AMETH_RS00520	COG2372	response to copper ion
AMETH_RS00520	COG1276	copper resistance
AMETH_RS00535	COG1174	glycine betaine transport
AMETH_RS00545	COG1174	glycine betaine transport
AMETH_RS00580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMETH_RS00600	COG4585	Histidine kinase
AMETH_RS00605	COG2197	response regulator
AMETH_RS00620	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS00625	COG4106	trans-aconitate 2-methyltransferase activity
AMETH_RS00665	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_RS00670	COG0022	dehydrogenase e1 component
AMETH_RS00680	COG0683	leucine binding
AMETH_RS00695	COG1022	Amp-dependent synthetase and ligase
AMETH_RS00710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_RS00720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMETH_RS00725	COG0765	amino acid transport
AMETH_RS00755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMETH_RS00760	COG3275	phosphorelay sensor kinase activity
AMETH_RS00780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_RS00790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_RS00795	COG0425	Belongs to the sulfur carrier protein TusA family
AMETH_RS00795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AMETH_RS00820	COG1191	sigma factor activity
AMETH_RS00875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_RS00880	COG1309	transcriptional regulator
AMETH_RS00895	COG1271	oxidase subunit
AMETH_RS00900	COG1294	oxidase, subunit
AMETH_RS00905	COG4988	ABC transporter
AMETH_RS00925	COG1846	Transcriptional regulator
AMETH_RS00930	COG1289	transmembrane transporter activity
AMETH_RS00995	COG1072	(Pantothenic acid kinase))
AMETH_RS01000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AMETH_RS01010	COG0406	alpha-ribazole phosphatase activity
AMETH_RS01025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_RS01050	COG0754	glutathionylspermidine amidase activity
AMETH_RS01055	COG3766	membrane
AMETH_RS01060	COG0596	Alpha beta hydrolase
AMETH_RS01070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AMETH_RS01075	COG3473	Maleate cis-trans isomerase
AMETH_RS01085	COG0579	oxidoreductase
AMETH_RS01105	COG1276	copper resistance
AMETH_RS01105	COG2372	response to copper ion
AMETH_RS01180	COG0561	phosphatase activity
AMETH_RS01185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS01200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMETH_RS01225	COG1216	Glycosyl transferase, family 2
AMETH_RS01235	COG0277	FAD linked oxidase domain protein
AMETH_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS01250	COG1216	Glycosyl transferase, family 2
AMETH_RS01280	COG1063	alcohol dehydrogenase
AMETH_RS01285	COG2234	aminopeptidase activity
AMETH_RS01310	COG2188	Transcriptional regulator
AMETH_RS01335	COG0443	Heat shock 70 kDa protein
AMETH_RS01360	COG4585	Histidine kinase
AMETH_RS01365	COG2197	response regulator
AMETH_RS01385	COG1522	sequence-specific DNA binding
AMETH_RS01405	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMETH_RS01435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMETH_RS01445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_RS01450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMETH_RS01450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMETH_RS01480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS01485	COG2124	cytochrome p450
AMETH_RS01495	COG0477	Major facilitator Superfamily
AMETH_RS01500	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS01510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS01535	COG1309	transcriptional regulator
AMETH_RS01540	COG1937	Protein conserved in bacteria
AMETH_RS01545	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AMETH_RS01560	COG2072	flavoprotein involved in K transport
AMETH_RS01570	COG0028	Belongs to the TPP enzyme family
AMETH_RS01590	COG2723	6-phospho-beta-galactosidase activity
AMETH_RS01630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS01635	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS01640	COG1120	ATPase activity
AMETH_RS01650	COG3559	Exporter of polyketide antibiotics
AMETH_RS01655	COG1131	(ABC) transporter
AMETH_RS01720	COG0287	Prephenate dehydrogenase
AMETH_RS01725	COG1473	amidohydrolase
AMETH_RS01770	COG1674	ftsk spoiiie
AMETH_RS01800	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AMETH_RS01820	COG1414	Transcriptional regulator
AMETH_RS01825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMETH_RS01860	COG1472	Belongs to the glycosyl hydrolase 3 family
AMETH_RS01945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_RS01965	COG2733	membrane
AMETH_RS01985	COG1136	(ABC) transporter
AMETH_RS02000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMETH_RS02005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AMETH_RS02030	COG1174	glycine betaine transport
AMETH_RS02035	COG1174	glycine betaine transport
AMETH_RS02050	COG2130	NADP-dependent
AMETH_RS02090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AMETH_RS02105	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS02115	COG0588	phosphoglycerate mutase activity
AMETH_RS02125	COG3226	Transcriptional regulator
AMETH_RS02135	COG0667	Aldo Keto reductase
AMETH_RS02140	COG5002	protein histidine kinase activity
AMETH_RS02160	COG1082	Xylose isomerase domain protein TIM barrel
AMETH_RS02165	COG0506	proline dehydrogenase activity
AMETH_RS02175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AMETH_RS02210	COG1595	DNA-templated transcription, initiation
AMETH_RS02215	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS02230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AMETH_RS02235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AMETH_RS02240	COG0181	hydroxymethylbilane synthase activity
AMETH_RS02245	COG1648	precorrin-2 dehydrogenase activity
AMETH_RS02245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMETH_RS02270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMETH_RS02275	COG0406	alpha-ribazole phosphatase activity
AMETH_RS02300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AMETH_RS02325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AMETH_RS02340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AMETH_RS02345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AMETH_RS02380	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS02385	COG2226	methyltransferase
AMETH_RS02405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMETH_RS02410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMETH_RS02415	COG0649	NAD binding
AMETH_RS02430	COG1034	ATP synthesis coupled electron transport
AMETH_RS02435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AMETH_RS02440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AMETH_RS02445	COG0839	Belongs to the complex I subunit 6 family
AMETH_RS02450	COG0713	ATP synthesis coupled electron transport
AMETH_RS02465	COG1007	ATP synthesis coupled electron transport
AMETH_RS02480	COG0142	geranyltranstransferase activity
AMETH_RS02490	COG1013	pyruvate-flavodoxin oxidoreductase activity
AMETH_RS02495	COG0674	pyruvate-flavodoxin oxidoreductase activity
AMETH_RS02495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AMETH_RS02505	COG1522	sequence-specific DNA binding
AMETH_RS02510	COG1834	amidinotransferase
AMETH_RS02520	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMETH_RS02535	COG4310	Domain of unknown function (DUF2172)
AMETH_RS02545	COG1216	Glycosyl transferase, family 2
AMETH_RS02560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AMETH_RS02630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMETH_RS02640	COG0297	glycogen (starch) synthase activity
AMETH_RS02645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMETH_RS02670	COG0367	asparagine synthase
AMETH_RS02690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMETH_RS02695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS02705	COG0501	Belongs to the peptidase M48B family
AMETH_RS02710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AMETH_RS02715	COG0596	Alpha beta hydrolase
AMETH_RS02720	COG1309	transcriptional regulator
AMETH_RS02725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMETH_RS02765	COG1666	GTP binding
AMETH_RS02805	COG1674	ftsk spoiiie
AMETH_RS02870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMETH_RS02900	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMETH_RS02905	COG2205	protein histidine kinase activity
AMETH_RS02910	COG0577	efflux transmembrane transporter activity
AMETH_RS02920	COG4941	Belongs to the sigma-70 factor family
AMETH_RS02930	COG1793	dna ligase
AMETH_RS02945	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AMETH_RS02950	COG1169	isochorismate synthase
AMETH_RS02955	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS02960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS02965	COG1021	2,3-dihydroxybenzoate-AMP ligase
AMETH_RS02970	COG0477	Major facilitator Superfamily
AMETH_RS02990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMETH_RS03000	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AMETH_RS03010	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS03025	COG2197	response regulator
AMETH_RS03030	COG2132	Multicopper oxidase
AMETH_RS03045	COG4585	Histidine kinase
AMETH_RS03050	COG0586	Pfam SNARE associated Golgi protein
AMETH_RS03055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AMETH_RS03060	COG5001	Diguanylate cyclase
AMETH_RS03075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AMETH_RS03080	COG2030	dehydratase
AMETH_RS03100	COG2755	lipolytic protein G-D-S-L family
AMETH_RS03105	COG0436	Aminotransferase
AMETH_RS03115	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AMETH_RS03130	COG0081	regulation of translation
AMETH_RS03145	COG0222	ribosome binding
AMETH_RS03160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS03185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMETH_RS03210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AMETH_RS03230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AMETH_RS03235	COG0049	tRNA binding
AMETH_RS03240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AMETH_RS03250	COG0051	transcription antitermination factor activity, RNA binding
AMETH_RS03255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AMETH_RS03260	COG0088	Forms part of the polypeptide exit tunnel
AMETH_RS03265	COG0089	rRNA binding
AMETH_RS03270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AMETH_RS03275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AMETH_RS03280	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AMETH_RS03285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AMETH_RS03295	COG0255	Belongs to the universal ribosomal protein uL29 family
AMETH_RS03300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AMETH_RS03305	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AMETH_RS03310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AMETH_RS03315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AMETH_RS03325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AMETH_RS03330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AMETH_RS03335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AMETH_RS03340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AMETH_RS03345	COG1841	ribosomal large subunit assembly
AMETH_RS03370	COG0563	adenylate kinase activity
AMETH_RS03380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AMETH_RS03385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AMETH_RS03390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AMETH_RS03400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AMETH_RS03405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AMETH_RS03410	COG0202	RNA polymerase activity
AMETH_RS03415	COG0203	ribosomal protein L17
AMETH_RS03420	COG0101	tRNA pseudouridine synthase activity
AMETH_RS03440	COG3266	domain, Protein
AMETH_RS03445	COG1404	Belongs to the peptidase S8 family
AMETH_RS03455	COG1674	ftsk spoiiie
AMETH_RS03460	COG0443	Heat shock 70 kDa protein
AMETH_RS03485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AMETH_RS03495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMETH_RS03520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_RS03535	COG1175	transmembrane transport
AMETH_RS03540	COG0395	ABC-type sugar transport system, permease component
AMETH_RS03545	COG1063	alcohol dehydrogenase
AMETH_RS03550	COG1349	DNA-binding transcription factor activity
AMETH_RS03555	COG1070	Carbohydrate kinase
AMETH_RS03560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AMETH_RS03570	COG0802	atpase or kinase
AMETH_RS03580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AMETH_RS03580	COG0825	malonyl-CoA metabolic process
AMETH_RS03585	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS03595	COG2186	Transcriptional regulator
AMETH_RS03605	COG0456	acetyltransferase
AMETH_RS03610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AMETH_RS03620	COG1733	regulation of RNA biosynthetic process
AMETH_RS03630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMETH_RS03635	COG0459	protein refolding
AMETH_RS03645	COG1309	transcriptional regulator
AMETH_RS03690	COG0516	GMP reductase activity
AMETH_RS03720	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS03730	COG0519	Catalyzes the synthesis of GMP from XMP
AMETH_RS03730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AMETH_RS03760	COG0583	DNA-binding transcription factor activity
AMETH_RS03770	COG0515	serine threonine protein kinase
AMETH_RS03810	COG0739	heme binding
AMETH_RS03825	COG0045	succinate-CoA ligase (ADP-forming) activity
AMETH_RS03850	COG0138	bifunctional purine biosynthesis protein purh
AMETH_RS03855	COG0384	phenazine biosynthesis protein PhzF
AMETH_RS03875	COG0587	DNA-directed DNA polymerase activity
AMETH_RS03880	COG2816	NAD+ diphosphatase activity
AMETH_RS03885	COG0583	DNA-binding transcription factor activity
AMETH_RS03910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMETH_RS03920	COG2814	Major facilitator Superfamily
AMETH_RS03980	COG1234	tRNA 3'-trailer cleavage
AMETH_RS03985	COG0708	Exodeoxyribonuclease III
AMETH_RS04015	COG0180	Tryptophanyl-tRNA synthetase
AMETH_RS04020	COG1295	ribonuclease BN
AMETH_RS04025	COG1686	Belongs to the peptidase S11 family
AMETH_RS04040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMETH_RS04055	COG2009	succinate dehydrogenase
AMETH_RS04060	COG1744	ABC transporter substrate-binding protein PnrA-like
AMETH_RS04065	COG3845	ABC transporter
AMETH_RS04075	COG1079	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS04095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AMETH_RS04100	COG2271	Major facilitator Superfamily
AMETH_RS04130	COG2124	cytochrome p450
AMETH_RS04140	COG1063	alcohol dehydrogenase
AMETH_RS04155	COG0395	ABC-type sugar transport system, permease component
AMETH_RS04165	COG2124	cytochrome p450
AMETH_RS04180	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS04185	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS04190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AMETH_RS04220	COG0667	Aldo Keto reductase
AMETH_RS04250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMETH_RS04260	COG0515	serine threonine protein kinase
AMETH_RS04285	COG1473	amidohydrolase
AMETH_RS04285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMETH_RS04315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMETH_RS04320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AMETH_RS04325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMETH_RS04350	COG4770	biotin carboxylase activity
AMETH_RS04360	COG1301	dicarboxylic acid transport
AMETH_RS04365	COG0424	maF-like protein
AMETH_RS04385	COG1802	Transcriptional regulator
AMETH_RS04400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMETH_RS04415	COG0640	Transcriptional regulator
AMETH_RS04420	COG3467	pyridoxamine 5'-phosphate
AMETH_RS04450	COG1388	LysM domain
AMETH_RS04450	COG0791	NLP P60 protein
AMETH_RS04450	COG3103	Sh3 type 3 domain protein
AMETH_RS04495	COG0483	inositol monophosphate 1-phosphatase activity
AMETH_RS04500	COG0745	RESPONSE REGULATOR receiver
AMETH_RS04505	COG2205	protein histidine kinase activity
AMETH_RS04555	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS04575	COG2259	Doxx family
AMETH_RS04585	COG1316	TRANSCRIPTIONal
AMETH_RS04590	COG1316	TRANSCRIPTIONal
AMETH_RS04610	COG4221	oxidoreductase activity
AMETH_RS04615	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS04630	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS04660	COG1725	Transcriptional regulator
AMETH_RS04675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AMETH_RS04685	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMETH_RS04720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_RS04725	COG1611	Belongs to the LOG family
AMETH_RS04740	COG0463	Glycosyl transferase, family 2
AMETH_RS04755	COG2818	Glycosylase
AMETH_RS04760	COG1024	Enoyl-CoA hydratase
AMETH_RS04770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AMETH_RS04775	COG0583	DNA-binding transcription factor activity
AMETH_RS04795	COG4122	O-methyltransferase activity
AMETH_RS04805	COG5662	AntiSigma factor
AMETH_RS04810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMETH_RS04815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AMETH_RS04830	COG2239	Acts as a magnesium transporter
AMETH_RS04840	COG0330	HflC and HflK could
AMETH_RS04845	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS04890	COG1309	transcriptional regulator
AMETH_RS04910	COG0598	Magnesium transport protein CorA
AMETH_RS04925	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS04940	COG0613	PHP domain protein
AMETH_RS04945	COG2095	MarC family integral membrane protein
AMETH_RS04990	COG0513	Belongs to the DEAD box helicase family
AMETH_RS05020	COG2267	carboxylic ester hydrolase activity
AMETH_RS05030	COG2267	carboxylic ester hydrolase activity
AMETH_RS05050	COG0243	molybdopterin cofactor binding
AMETH_RS05055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_RS05065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_RS05065	COG2146	nitrite reductase [NAD(P)H] activity
AMETH_RS05085	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS05110	COG2378	regulation of single-species biofilm formation
AMETH_RS05130	COG1074	ATP-dependent DNA helicase activity
AMETH_RS05140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMETH_RS05170	COG0714	Associated with various cellular activities
AMETH_RS05205	COG1309	transcriptional regulator
AMETH_RS05220	COG0612	Peptidase, M16
AMETH_RS05245	COG3265	gluconokinase activity
AMETH_RS05255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMETH_RS05275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AMETH_RS05290	COG2207	Transcriptional regulator
AMETH_RS05295	COG0667	Aldo Keto reductase
AMETH_RS05305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AMETH_RS05375	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AMETH_RS05385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AMETH_RS05400	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS05405	COG3842	ATPase activity
AMETH_RS05410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AMETH_RS05415	COG1176	ABC-type spermidine putrescine transport system, permease component I
AMETH_RS05420	COG1177	transmembrane transport
AMETH_RS05425	COG1968	undecaprenyl-diphosphatase activity
AMETH_RS05430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AMETH_RS05455	COG2318	DinB family
AMETH_RS05460	COG0653	protein targeting
AMETH_RS05480	COG4977	sequence-specific DNA binding
AMETH_RS05490	COG0174	glutamine synthetase
AMETH_RS05515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AMETH_RS05530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMETH_RS05550	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMETH_RS05555	COG2080	2 iron, 2 sulfur cluster binding
AMETH_RS05560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_RS05565	COG3835	regulator
AMETH_RS05580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AMETH_RS05600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMETH_RS05620	COG0174	glutamine synthetase
AMETH_RS05660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AMETH_RS05680	COG3480	Lon protease (S16) C-terminal proteolytic domain
AMETH_RS05690	COG1615	UPF0182 protein
AMETH_RS05710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMETH_RS05715	COG2884	Cell division ATP-binding protein ftsE
AMETH_RS05720	COG2177	Part of the ABC transporter FtsEX involved in
AMETH_RS05725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AMETH_RS05755	COG2197	response regulator
AMETH_RS05770	COG1414	Transcriptional regulator
AMETH_RS05775	COG2986	histidine ammonia-lyase
AMETH_RS05780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AMETH_RS05785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_RS05795	COG1228	amidohydrolase
AMETH_RS05860	COG1643	Atp-dependent helicase
AMETH_RS05880	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS05900	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS05910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS05915	COG0183	Belongs to the thiolase family
AMETH_RS05925	COG1309	transcriptional regulator
AMETH_RS05935	COG0145	ligase activity
AMETH_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS05955	COG1414	Transcriptional regulator
AMETH_RS05965	COG0492	ferredoxin-NADP+ reductase activity
AMETH_RS05970	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS05995	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS06005	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS06020	COG3384	dioxygenase
AMETH_RS06035	COG2124	cytochrome p450
AMETH_RS06070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS06075	COG1127	ABC transporter
AMETH_RS06115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AMETH_RS06130	COG0714	Associated with various cellular activities
AMETH_RS06215	COG1595	DNA-templated transcription, initiation
AMETH_RS06225	COG2205	protein histidine kinase activity
AMETH_RS06225	COG3437	response regulator, receiver
AMETH_RS06225	COG4999	Histidine kinase
AMETH_RS06225	COG3850	Histidine kinase
AMETH_RS06230	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_RS06235	COG0583	DNA-binding transcription factor activity
AMETH_RS06250	COG1119	ATPase activity
AMETH_RS06255	COG0583	DNA-binding transcription factor activity
AMETH_RS06260	COG3293	Transposase
AMETH_RS06280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AMETH_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS06340	COG1216	Glycosyl transferase, family 2
AMETH_RS06340	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS06350	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMETH_RS06355	COG0564	pseudouridine synthase activity
AMETH_RS06370	COG0187	DNA topoisomerase II activity
AMETH_RS06375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AMETH_RS06380	COG0657	acetylesterase activity
AMETH_RS06385	COG2208	phosphoserine phosphatase activity
AMETH_RS06390	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_RS06395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS06405	COG0583	DNA-binding transcription factor activity
AMETH_RS06410	COG0129	dihydroxy-acid dehydratase activity
AMETH_RS06435	COG4336	lyase activity
AMETH_RS06485	COG3537	Alpha-1,2-mannosidase
AMETH_RS06515	COG2079	MmgE PrpD family protein
AMETH_RS06525	COG2301	Belongs to the HpcH HpaI aldolase family
AMETH_RS06530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS06540	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS06545	COG4214	carbohydrate transport
AMETH_RS06570	COG1053	succinate dehydrogenase
AMETH_RS06585	COG3285	dna ligase
AMETH_RS06585	COG1793	dna ligase
AMETH_RS06605	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMETH_RS06610	COG1063	alcohol dehydrogenase
AMETH_RS06620	COG1280	lysine exporter protein (LysE YggA)
AMETH_RS06640	COG3191	aminopeptidase activity
AMETH_RS06650	COG1609	Transcriptional regulator
AMETH_RS06690	COG0018	arginyl-trna synthetase
AMETH_RS06695	COG0019	diaminopimelate decarboxylase activity
AMETH_RS06700	COG0460	homoserine dehydrogenase
AMETH_RS06705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMETH_RS06710	COG0083	homoserine kinase activity
AMETH_RS06725	COG0254	rRNA binding
AMETH_RS06730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AMETH_RS06735	COG2267	carboxylic ester hydrolase activity
AMETH_RS06745	COG2890	protein-(glutamine-N5) methyltransferase activity
AMETH_RS06755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMETH_RS06765	COG0356	it plays a direct role in the translocation of protons across the membrane
AMETH_RS06770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMETH_RS06775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AMETH_RS06780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AMETH_RS06785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AMETH_RS06790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AMETH_RS06795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AMETH_RS06800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AMETH_RS06825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AMETH_RS06835	COG1280	lysine exporter protein (LysE YggA)
AMETH_RS06840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMETH_RS06840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMETH_RS06850	COG0765	amino acid transport
AMETH_RS06855	COG0765	amino acid transport
AMETH_RS06860	COG1126	abc transporter atp-binding protein
AMETH_RS06865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMETH_RS06890	COG1414	Transcriptional regulator
AMETH_RS06900	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AMETH_RS06915	COG2814	Major facilitator Superfamily
AMETH_RS06925	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AMETH_RS06945	COG2376	Dihydroxyacetone kinase
AMETH_RS06975	COG1309	transcriptional regulator
AMETH_RS07010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMETH_RS07045	COG1335	isochorismatase
AMETH_RS07050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AMETH_RS07055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AMETH_RS07065	COG3191	aminopeptidase activity
AMETH_RS07105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AMETH_RS07110	COG1234	tRNA 3'-trailer cleavage
AMETH_RS07125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AMETH_RS07130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AMETH_RS07135	COG1984	allophanate hydrolase subunit 2
AMETH_RS07140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AMETH_RS07145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AMETH_RS07180	COG0300	oxidoreductase activity
AMETH_RS07205	COG1234	tRNA 3'-trailer cleavage
AMETH_RS07230	COG0110	maltose O-acetyltransferase activity
AMETH_RS07235	COG0431	NADPH-dependent FMN reductase
AMETH_RS07250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMETH_RS07285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AMETH_RS07300	COG1307	EDD domain protein, DegV family
AMETH_RS07310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AMETH_RS07340	COG0482	sulfurtransferase activity
AMETH_RS07350	COG2201	protein-glutamate methylesterase activity
AMETH_RS07395	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS07410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_RS07430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMETH_RS07450	COG2409	Drug exporters of the RND superfamily
AMETH_RS07460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AMETH_RS07465	COG0154	amidase activity
AMETH_RS07495	COG2259	Doxx family
AMETH_RS07500	COG0129	dihydroxy-acid dehydratase activity
AMETH_RS07510	COG1335	isochorismatase
AMETH_RS07535	COG0440	acetolactate synthase activity
AMETH_RS07540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMETH_RS07555	COG1404	Belongs to the peptidase S8 family
AMETH_RS07560	COG0473	3-isopropylmalate dehydrogenase activity
AMETH_RS07565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_RS07585	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_RS07595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AMETH_RS07645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMETH_RS07650	COG0066	3-isopropylmalate dehydratase activity
AMETH_RS07670	COG1920	GTP binding
AMETH_RS07680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AMETH_RS07715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_RS07720	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMETH_RS07750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AMETH_RS07755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMETH_RS07760	COG1461	Dihydroxyacetone kinase
AMETH_RS07785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMETH_RS07790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS07800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMETH_RS07805	COG3973	AAA domain
AMETH_RS07810	COG0742	ribosomal rna small subunit methyltransferase
AMETH_RS07815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AMETH_RS07835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AMETH_RS07840	COG0571	ribonuclease III activity
AMETH_RS07845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMETH_RS07850	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AMETH_RS07865	COG0367	asparagine synthase
AMETH_RS07875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AMETH_RS07880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AMETH_RS07885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AMETH_RS07910	COG1254	Belongs to the acylphosphatase family
AMETH_RS07930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_RS07935	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AMETH_RS07975	COG1414	Transcriptional regulator
AMETH_RS07980	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AMETH_RS07995	COG3835	regulator
AMETH_RS08015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_RS08035	COG2233	PERMEase
AMETH_RS08060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMETH_RS08065	COG4266	Belongs to the allantoicase family
AMETH_RS08075	COG1832	CoA-binding protein
AMETH_RS08080	COG2873	o-acetylhomoserine
AMETH_RS08090	COG2267	carboxylic ester hydrolase activity
AMETH_RS08115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AMETH_RS08150	COG0228	four-way junction DNA binding
AMETH_RS08160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AMETH_RS08165	COG0336	Belongs to the RNA methyltransferase TrmD family
AMETH_RS08170	COG0335	large ribosomal subunit rRNA binding
AMETH_RS08175	COG0681	Belongs to the peptidase S26 family
AMETH_RS08180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AMETH_RS08190	COG0792	nuclease activity
AMETH_RS08210	COG1191	sigma factor activity
AMETH_RS08220	COG0052	Belongs to the universal ribosomal protein uS2 family
AMETH_RS08225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AMETH_RS08230	COG0528	UMP kinase activity
AMETH_RS08235	COG0233	cytoplasmic translational termination
AMETH_RS08265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AMETH_RS08275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AMETH_RS08280	COG0750	zinc metalloprotease
AMETH_RS08285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AMETH_RS08315	COG2186	Transcriptional regulator
AMETH_RS08320	COG2807	transmembrane transport
AMETH_RS08360	COG1733	regulation of RNA biosynthetic process
AMETH_RS08365	COG0513	Belongs to the DEAD box helicase family
AMETH_RS08375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMETH_RS08380	COG3022	response to hydroperoxide
AMETH_RS08405	COG0539	negative regulation of cytoplasmic translation
AMETH_RS08405	COG1185	polyribonucleotide nucleotidyltransferase activity
AMETH_RS08405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMETH_RS08420	COG1609	Transcriptional regulator
AMETH_RS08450	COG2902	Dehydrogenase
AMETH_RS08465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS08475	COG0668	transmembrane transport
AMETH_RS08490	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AMETH_RS08500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMETH_RS08530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMETH_RS08545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AMETH_RS08575	COG2186	Transcriptional regulator
AMETH_RS08615	COG1793	dna ligase
AMETH_RS08615	COG3285	dna ligase
AMETH_RS08635	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS08660	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMETH_RS08665	COG2205	protein histidine kinase activity
AMETH_RS08685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_RS08690	COG0544	peptidyl-prolyl cis-trans isomerase activity
AMETH_RS08695	COG0740	serine-type endopeptidase activity
AMETH_RS08700	COG0740	serine-type endopeptidase activity
AMETH_RS08705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AMETH_RS08725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AMETH_RS08760	COG2353	YceI-like domain
AMETH_RS08765	COG0346	lactoylglutathione lyase activity
AMETH_RS08775	COG0477	Major facilitator Superfamily
AMETH_RS08790	COG0525	valine-tRNA ligase activity
AMETH_RS08810	COG2755	lipolytic protein G-D-S-L family
AMETH_RS08815	COG2188	Transcriptional regulator
AMETH_RS08820	COG1397	ADP-ribosylglycohydrolase
AMETH_RS08830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMETH_RS08835	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS08840	COG0154	amidase activity
AMETH_RS08855	COG0285	dihydrofolate synthase activity
AMETH_RS08875	COG0105	UTP biosynthetic process
AMETH_RS08880	COG1414	Transcriptional regulator
AMETH_RS08885	COG1131	(ABC) transporter
AMETH_RS08905	COG1530	ribonuclease E activity
AMETH_RS08905	COG1530	ribonuclease E activity
AMETH_RS08910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AMETH_RS08915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AMETH_RS08920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AMETH_RS08930	COG0477	Major facilitator Superfamily
AMETH_RS08935	COG0514	ATP-dependent DNA helicase (RecQ)
AMETH_RS08940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AMETH_RS08945	COG0799	negative regulation of ribosome biogenesis
AMETH_RS08955	COG2755	lipolytic protein G-D-S-L family
AMETH_RS08960	COG1307	EDD domain protein, DegV family
AMETH_RS08965	COG1596	polysaccharide export
AMETH_RS08965	COG1555	photosystem II stabilization
AMETH_RS08970	COG0658	competence protein
AMETH_RS08970	COG2333	competence protein COMEC
AMETH_RS08975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AMETH_RS08985	COG0268	Binds directly to 16S ribosomal RNA
AMETH_RS09030	COG2070	2-Nitropropane dioxygenase
AMETH_RS09050	COG1802	Transcriptional regulator
AMETH_RS09055	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS09065	COG0477	Major facilitator Superfamily
AMETH_RS09090	COG2080	2 iron, 2 sulfur cluster binding
AMETH_RS09090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_RS09100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMETH_RS09105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS09120	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS09155	COG1309	transcriptional regulator
AMETH_RS09160	COG0022	dehydrogenase e1 component
AMETH_RS09165	COG1063	alcohol dehydrogenase
AMETH_RS09170	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS09185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_RS09190	COG4191	Histidine kinase
AMETH_RS09205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS09210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS09215	COG1127	ABC transporter
AMETH_RS09260	COG2197	response regulator
AMETH_RS09265	COG3384	dioxygenase
AMETH_RS09295	COG2368	4-hydroxyphenylacetate
AMETH_RS09300	COG2267	carboxylic ester hydrolase activity
AMETH_RS09315	COG4638	Rieske (2fe-2S)
AMETH_RS09340	COG2086	electron transfer activity
AMETH_RS09365	COG0531	amino acid
AMETH_RS09380	COG0604	alcohol dehydrogenase
AMETH_RS09395	COG2732	(Barnase) inhibitor
AMETH_RS09405	COG1024	Enoyl-CoA hydratase
AMETH_RS09430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMETH_RS09440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMETH_RS09475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AMETH_RS09535	COG2124	cytochrome p450
AMETH_RS09570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMETH_RS09580	COG1953	Uracil, thiamine, allantoin
AMETH_RS09595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMETH_RS09610	COG0484	heat shock protein binding
AMETH_RS09620	COG0537	adenosine 5'-monophosphoramidase activity
AMETH_RS09630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AMETH_RS09645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AMETH_RS09660	COG1381	Involved in DNA repair and RecF pathway recombination
AMETH_RS09665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AMETH_RS09675	COG0701	Predicted permease
AMETH_RS09705	COG0423	glycine-tRNA ligase activity
AMETH_RS09715	COG1396	sequence-specific DNA binding
AMETH_RS09720	COG1131	(ABC) transporter
AMETH_RS09730	COG4585	Histidine kinase
AMETH_RS09735	COG2197	response regulator
AMETH_RS09780	COG1595	DNA-templated transcription, initiation
AMETH_RS09785	COG0358	DNA primase activity
AMETH_RS09795	COG4106	trans-aconitate 2-methyltransferase activity
AMETH_RS09800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMETH_RS09890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS09895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS09945	COG0410	ABC transporter
AMETH_RS09950	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS09975	COG3467	pyridoxamine 5'-phosphate
AMETH_RS10045	COG0124	histidyl-tRNA synthetase
AMETH_RS10055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_RS10060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AMETH_RS10065	COG2080	2 iron, 2 sulfur cluster binding
AMETH_RS10070	COG1802	Transcriptional regulator
AMETH_RS10080	COG1454	alcohol dehydrogenase
AMETH_RS10090	COG0277	FAD linked oxidase domain protein
AMETH_RS10090	COG0247	lactate metabolic process
AMETH_RS10110	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS10120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_RS10135	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS10140	COG0183	Belongs to the thiolase family
AMETH_RS10145	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS10150	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS10155	COG1024	Enoyl-CoA hydratase
AMETH_RS10160	COG1024	Enoyl-CoA hydratase
AMETH_RS10165	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS10170	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS10190	COG0009	L-threonylcarbamoyladenylate synthase
AMETH_RS10200	COG4221	oxidoreductase activity
AMETH_RS10250	COG1024	Enoyl-CoA hydratase
AMETH_RS10255	COG0406	alpha-ribazole phosphatase activity
AMETH_RS10290	COG0302	gtp cyclohydrolase
AMETH_RS10315	COG0523	cobalamin synthesis protein
AMETH_RS10320	COG4565	transcriptional regulatory protein
AMETH_RS10325	COG3290	protein histidine kinase activity
AMETH_RS10355	COG1309	transcriptional regulator
AMETH_RS10360	COG0791	NLP P60 protein
AMETH_RS10365	COG1984	allophanate hydrolase subunit 2
AMETH_RS10370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AMETH_RS10400	COG1674	ftsk spoiiie
AMETH_RS10470	COG3629	intracellular signal transduction
AMETH_RS10470	COG3903	Transcriptional regulator
AMETH_RS10475	COG3629	intracellular signal transduction
AMETH_RS10475	COG3903	Transcriptional regulator
AMETH_RS10480	COG2197	response regulator
AMETH_RS10485	COG3903	Transcriptional regulator
AMETH_RS10485	COG3629	intracellular signal transduction
AMETH_RS10505	COG0671	phosphoesterase, PA-phosphatase related
AMETH_RS10545	COG1595	DNA-templated transcription, initiation
AMETH_RS10580	COG2011	ABC-type metal ion transport system permease component
AMETH_RS10585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMETH_RS10590	COG1464	Belongs to the NlpA lipoprotein family
AMETH_RS10615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMETH_RS10635	COG3473	Maleate cis-trans isomerase
AMETH_RS10640	COG1737	Transcriptional regulator
AMETH_RS10645	COG1609	Transcriptional regulator
AMETH_RS10650	COG1129	ABC transporter
AMETH_RS10655	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS10660	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS10680	COG3347	Dehydrogenase
AMETH_RS10690	COG1070	Carbohydrate kinase
AMETH_RS10695	COG0247	lactate metabolic process
AMETH_RS10700	COG1139	Iron-sulfur cluster binding protein
AMETH_RS10705	COG1556	Lactate utilization protein
AMETH_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS10735	COG0402	S-adenosylhomocysteine deaminase activity
AMETH_RS10740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS10765	COG1414	Transcriptional regulator
AMETH_RS10775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMETH_RS10785	COG0789	Transcriptional regulator
AMETH_RS10790	COG2814	Major facilitator Superfamily
AMETH_RS10795	COG0477	Major facilitator Superfamily
AMETH_RS10825	COG0477	Major facilitator Superfamily
AMETH_RS10855	COG4829	muconolactone delta-isomerase
AMETH_RS10860	COG3485	protocatechuate 3,4-dioxygenase
AMETH_RS10865	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_RS10870	COG0583	DNA-binding transcription factor activity
AMETH_RS10875	COG4638	Rieske (2fe-2S)
AMETH_RS10890	COG2814	Major facilitator Superfamily
AMETH_RS10900	COG3135	benzoate transporter
AMETH_RS10910	COG3285	dna ligase
AMETH_RS10910	COG1793	dna ligase
AMETH_RS10920	COG0702	epimerase
AMETH_RS10930	COG0515	serine threonine protein kinase
AMETH_RS10950	COG0673	inositol 2-dehydrogenase activity
AMETH_RS10965	COG0405	Gamma-glutamyltransferase
AMETH_RS11005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMETH_RS11080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMETH_RS11085	COG0473	3-isopropylmalate dehydrogenase activity
AMETH_RS11100	COG1609	Transcriptional regulator
AMETH_RS11115	COG0477	Major facilitator Superfamily
AMETH_RS11130	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS11150	COG1942	4-Oxalocrotonate Tautomerase
AMETH_RS11155	COG0477	Major facilitator Superfamily
AMETH_RS11170	COG2376	Dihydroxyacetone kinase
AMETH_RS11175	COG0698	ribose 5-phosphate isomerase
AMETH_RS11185	COG3959	Transketolase, thiamine diphosphate binding domain
AMETH_RS11190	COG3958	Transketolase
AMETH_RS11195	COG2197	response regulator
AMETH_RS11200	COG0477	Major facilitator Superfamily
AMETH_RS11205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_RS11210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS11215	COG0640	Transcriptional regulator
AMETH_RS11220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS11245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS11285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMETH_RS11295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS11300	COG2301	Belongs to the HpcH HpaI aldolase family
AMETH_RS11380	COG0300	oxidoreductase activity
AMETH_RS11425	COG3209	COG3209 Rhs family protein
AMETH_RS11425	COG4104	PAAR repeat-containing protein
AMETH_RS11430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AMETH_RS11445	COG4152	abc transporter atp-binding protein
AMETH_RS11500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS11510	COG0488	(ABC) transporter
AMETH_RS11540	COG1595	DNA-templated transcription, initiation
AMETH_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS11630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMETH_RS11635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMETH_RS11675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS11685	COG1408	metallophosphoesterase
AMETH_RS11710	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMETH_RS11715	COG1739	Uncharacterized protein family UPF0029
AMETH_RS11740	COG2186	Transcriptional regulator
AMETH_RS11745	COG0473	3-isopropylmalate dehydrogenase activity
AMETH_RS11765	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS11825	COG1063	alcohol dehydrogenase
AMETH_RS11830	COG0459	protein refolding
AMETH_RS11835	COG1024	Enoyl-CoA hydratase
AMETH_RS11845	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS11850	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMETH_RS11870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMETH_RS11875	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_RS11880	COG0022	dehydrogenase e1 component
AMETH_RS11880	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_RS11885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMETH_RS11905	COG3732	PTS system glucitol sorbitol-specific
AMETH_RS11915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMETH_RS11920	COG2390	Transcriptional regulator
AMETH_RS11925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMETH_RS11975	COG0745	RESPONSE REGULATOR receiver
AMETH_RS11980	COG5002	protein histidine kinase activity
AMETH_RS11990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS11995	COG3384	dioxygenase
AMETH_RS12010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMETH_RS12015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS12015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS12070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS12090	COG0604	alcohol dehydrogenase
AMETH_RS12100	COG0646	methionine synthase
AMETH_RS12100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AMETH_RS12105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMETH_RS12110	COG0402	S-adenosylhomocysteine deaminase activity
AMETH_RS12160	COG0779	Required for maturation of 30S ribosomal subunits
AMETH_RS12175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AMETH_RS12185	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AMETH_RS12200	COG0300	oxidoreductase activity
AMETH_RS12225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMETH_RS12240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AMETH_RS12260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AMETH_RS12265	COG1185	polyribonucleotide nucleotidyltransferase activity
AMETH_RS12275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AMETH_RS12290	COG0667	Aldo Keto reductase
AMETH_RS12310	COG1733	regulation of RNA biosynthetic process
AMETH_RS12325	COG3214	Protein conserved in bacteria
AMETH_RS12355	COG2815	serine threonine protein kinase
AMETH_RS12355	COG0515	serine threonine protein kinase
AMETH_RS12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_RS12365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AMETH_RS12405	COG0477	Major facilitator Superfamily
AMETH_RS12425	COG1674	ftsk spoiiie
AMETH_RS12435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AMETH_RS12440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMETH_RS12450	COG1546	Belongs to the CinA family
AMETH_RS12450	COG1058	Belongs to the CinA family
AMETH_RS12455	COG1396	sequence-specific DNA binding
AMETH_RS12460	COG1842	Phage shock protein A
AMETH_RS12475	COG0167	dihydroorotate dehydrogenase activity
AMETH_RS12495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AMETH_RS12510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMETH_RS12520	COG1609	Transcriptional regulator
AMETH_RS12530	COG1305	Transglutaminase-like
AMETH_RS12540	COG0714	Associated with various cellular activities
AMETH_RS12565	COG2001	Belongs to the MraZ family
AMETH_RS12570	COG0275	rRNA processing
AMETH_RS12580	COG0768	penicillin binding
AMETH_RS12585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AMETH_RS12595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AMETH_RS12600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMETH_RS12610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AMETH_RS12615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AMETH_RS12620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AMETH_RS12655	COG1799	cell septum assembly
AMETH_RS12680	COG2226	methyltransferase
AMETH_RS12695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AMETH_RS12705	COG0640	Transcriptional regulator
AMETH_RS12710	COG3263	regulation of cellular component size
AMETH_RS12715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMETH_RS12720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AMETH_RS12755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS12785	COG0154	amidase activity
AMETH_RS12800	COG0542	response to heat
AMETH_RS12820	COG0297	glycogen (starch) synthase activity
AMETH_RS12825	COG3546	catalase activity
AMETH_RS12840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AMETH_RS12845	COG2192	nodulation
AMETH_RS12850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AMETH_RS12855	COG0859	PFAM glycosyl transferase family 9
AMETH_RS12860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AMETH_RS12865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMETH_RS12865	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMETH_RS12875	COG0859	PFAM glycosyl transferase family 9
AMETH_RS12880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AMETH_RS12910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMETH_RS12955	COG2186	Transcriptional regulator
AMETH_RS12960	COG3386	PFAM SMP-30 Gluconolaconase
AMETH_RS12975	COG1316	TRANSCRIPTIONal
AMETH_RS12995	COG0237	dephospho-CoA kinase activity
AMETH_RS12995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AMETH_RS13065	COG1131	(ABC) transporter
AMETH_RS13075	COG4946	Tricorn protease homolog
AMETH_RS13075	COG0823	Involved in the tonB-independent uptake of proteins
AMETH_RS13075	COG1506	peptidase
AMETH_RS13090	COG1129	ABC transporter
AMETH_RS13095	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS13100	COG1879	ABC-type sugar transport system periplasmic component
AMETH_RS13105	COG1609	Transcriptional regulator
AMETH_RS13110	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
AMETH_RS13115	COG1070	Carbohydrate kinase
AMETH_RS13120	COG1285	pathogenesis
AMETH_RS13155	COG0328	RNA-DNA hybrid ribonuclease activity
AMETH_RS13165	COG1864	DNA RNA non-specific endonuclease
AMETH_RS13165	COG3591	Belongs to the peptidase S1B family
AMETH_RS13215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_RS13250	COG1301	dicarboxylic acid transport
AMETH_RS13255	COG3290	protein histidine kinase activity
AMETH_RS13260	COG4565	transcriptional regulatory protein
AMETH_RS13270	COG2706	6-phosphogluconolactonase activity
AMETH_RS13275	COG2610	gluconate transmembrane transporter activity
AMETH_RS13280	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMETH_RS13295	COG0251	oxidation-reduction process
AMETH_RS13310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AMETH_RS13315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AMETH_RS13320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_RS13325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AMETH_RS13330	COG0072	phenylalanine-tRNA ligase activity
AMETH_RS13330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMETH_RS13350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AMETH_RS13355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AMETH_RS13360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AMETH_RS13365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMETH_RS13370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AMETH_RS13380	COG0165	Argininosuccinate lyase
AMETH_RS13390	COG2094	Belongs to the DNA glycosylase MPG family
AMETH_RS13395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AMETH_RS13420	COG0647	UMP catabolic process
AMETH_RS13435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMETH_RS13465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AMETH_RS13470	COG0504	CTP synthase activity
AMETH_RS13475	COG0494	nUDIX hydrolase
AMETH_RS13500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AMETH_RS13510	COG0514	ATP-dependent DNA helicase (RecQ)
AMETH_RS13520	COG0475	glutathione-regulated potassium exporter activity
AMETH_RS13540	COG1160	GTP binding
AMETH_RS13555	COG4213	ABC transporter substrate-binding protein
AMETH_RS13565	COG4214	carbohydrate transport
AMETH_RS13635	COG0583	DNA-binding transcription factor activity
AMETH_RS13640	COG2851	Citrate transporter
AMETH_RS13680	COG0577	efflux transmembrane transporter activity
AMETH_RS13680	COG1136	(ABC) transporter
AMETH_RS13690	COG2124	cytochrome p450
AMETH_RS13700	COG1414	Transcriptional regulator
AMETH_RS13705	COG0745	RESPONSE REGULATOR receiver
AMETH_RS13715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMETH_RS13720	COG1116	anion transmembrane transporter activity
AMETH_RS13725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AMETH_RS13730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS13740	COG0506	proline dehydrogenase activity
AMETH_RS13745	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS13750	COG2508	Transcriptional regulator
AMETH_RS13750	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMETH_RS13760	COG1309	transcriptional regulator
AMETH_RS13765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AMETH_RS13770	COG3281	Trehalose synthase
AMETH_RS13775	COG0366	Alpha amylase catalytic
AMETH_RS13780	COG0366	Alpha amylase catalytic
AMETH_RS13835	COG2843	Capsule synthesis protein
AMETH_RS13850	COG1940	carbohydrate kinase activity
AMETH_RS13865	COG1129	ABC transporter
AMETH_RS13870	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS13875	COG1879	ABC-type sugar transport system periplasmic component
AMETH_RS13890	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AMETH_RS13925	COG1802	Transcriptional regulator
AMETH_RS13930	COG0628	permease
AMETH_RS13935	COG1268	BioY protein
AMETH_RS13950	COG1122	ATPase activity
AMETH_RS13965	COG1982	Orn Lys Arg decarboxylase major
AMETH_RS13990	COG1024	Enoyl-CoA hydratase
AMETH_RS13990	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_RS14000	COG1063	alcohol dehydrogenase
AMETH_RS14010	COG0646	methionine synthase
AMETH_RS14010	COG1410	methionine synthase
AMETH_RS14045	COG2115	Belongs to the xylose isomerase family
AMETH_RS14050	COG3842	ATPase activity
AMETH_RS14055	COG1940	carbohydrate kinase activity
AMETH_RS14075	COG1802	Transcriptional regulator
AMETH_RS14100	COG2226	methyltransferase
AMETH_RS14120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMETH_RS14125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMETH_RS14130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_RS14170	COG0583	DNA-binding transcription factor activity
AMETH_RS14180	COG1280	lysine exporter protein (LysE YggA)
AMETH_RS14240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AMETH_RS14250	COG1216	Glycosyl transferase, family 2
AMETH_RS14275	COG0110	maltose O-acetyltransferase activity
AMETH_RS14290	COG1215	transferase activity, transferring glycosyl groups
AMETH_RS14300	COG0778	Nitroreductase
AMETH_RS14320	COG1846	Transcriptional regulator
AMETH_RS14330	COG1560	Kdo2-lipid A biosynthetic process
AMETH_RS14335	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS14345	COG3608	succinylglutamate desuccinylase aspartoacylase
AMETH_RS14345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AMETH_RS14360	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AMETH_RS14365	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AMETH_RS14370	COG0217	transcriptional regulatory protein
AMETH_RS14380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AMETH_RS14385	COG0632	four-way junction helicase activity
AMETH_RS14390	COG2255	four-way junction helicase activity
AMETH_RS14400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMETH_RS14405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AMETH_RS14410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AMETH_RS14415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AMETH_RS14465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMETH_RS14475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AMETH_RS14490	COG2040	homocysteine
AMETH_RS14500	COG2124	cytochrome p450
AMETH_RS14540	COG1051	belongs to the nudix hydrolase family
AMETH_RS14545	COG2755	lipolytic protein G-D-S-L family
AMETH_RS14545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AMETH_RS14565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS14570	COG1120	ATPase activity
AMETH_RS14665	COG0596	Alpha beta hydrolase
AMETH_RS14670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMETH_RS14700	COG1064	alcohol dehydrogenase
AMETH_RS14705	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS14730	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AMETH_RS14735	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_RS14740	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS14815	COG0346	lactoylglutathione lyase activity
AMETH_RS14840	COG1309	transcriptional regulator
AMETH_RS14845	COG1511	domain protein
AMETH_RS14860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AMETH_RS14865	COG0539	negative regulation of cytoplasmic translation
AMETH_RS14875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMETH_RS14910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS14920	COG2211	Major facilitator Superfamily
AMETH_RS14930	COG0523	cobalamin synthesis protein
AMETH_RS14950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AMETH_RS14960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AMETH_RS14965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMETH_RS14975	COG1648	precorrin-2 dehydrogenase activity
AMETH_RS14975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AMETH_RS14990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_RS15015	COG1716	ATPase activity
AMETH_RS15070	COG3572	ergothioneine biosynthetic process
AMETH_RS15075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AMETH_RS15080	COG0121	glutamine amidotransferase
AMETH_RS15085	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AMETH_RS15105	COG4941	Belongs to the sigma-70 factor family
AMETH_RS15115	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AMETH_RS15130	COG3883	PFAM NLP P60 protein
AMETH_RS15130	COG0791	NLP P60 protein
AMETH_RS15140	COG0714	Associated with various cellular activities
AMETH_RS15165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AMETH_RS15170	COG3540	Alkaline phosphatase
AMETH_RS15175	COG2226	methyltransferase
AMETH_RS15195	COG0745	RESPONSE REGULATOR receiver
AMETH_RS15200	COG0477	Major facilitator Superfamily
AMETH_RS15210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMETH_RS15215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AMETH_RS15230	COG0517	IMP dehydrogenase activity
AMETH_RS15230	COG0617	tRNA 3'-terminal CCA addition
AMETH_RS15230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AMETH_RS15235	COG0589	response to stress
AMETH_RS15240	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AMETH_RS15245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AMETH_RS15295	COG2326	polyphosphate kinase activity
AMETH_RS15365	COG2080	2 iron, 2 sulfur cluster binding
AMETH_RS15380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMETH_RS15385	COG0640	Transcriptional regulator
AMETH_RS15390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMETH_RS15395	COG1993	acr, cog1993
AMETH_RS15400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMETH_RS15440	COG0477	Major facilitator Superfamily
AMETH_RS15455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS15460	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS15480	COG3850	Histidine kinase
AMETH_RS15485	COG2197	response regulator
AMETH_RS15495	COG0477	Major facilitator Superfamily
AMETH_RS15515	COG0531	amino acid
AMETH_RS15540	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS15545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AMETH_RS15570	COG4336	lyase activity
AMETH_RS15585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_RS15595	COG1175	transmembrane transport
AMETH_RS15600	COG0395	ABC-type sugar transport system, permease component
AMETH_RS15605	COG3842	ATPase activity
AMETH_RS15615	COG1940	carbohydrate kinase activity
AMETH_RS15625	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMETH_RS15630	COG2843	Capsule synthesis protein
AMETH_RS15640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_RS15650	COG0154	amidase activity
AMETH_RS15665	COG3328	transposase activity
AMETH_RS15675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AMETH_RS15725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AMETH_RS15730	COG0798	PFAM Bile acid sodium symporter
AMETH_RS15735	COG0640	Transcriptional regulator
AMETH_RS15740	COG2226	methyltransferase
AMETH_RS15750	COG2072	flavoprotein involved in K transport
AMETH_RS15765	COG1247	-acetyltransferase
AMETH_RS15810	COG0697	spore germination
AMETH_RS15835	COG2226	methyltransferase
AMETH_RS15855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AMETH_RS15860	COG0477	Major facilitator Superfamily
AMETH_RS15875	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS15890	COG1024	Enoyl-CoA hydratase
AMETH_RS15920	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS15925	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS15940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS15950	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS15960	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS15965	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS15970	COG1802	Transcriptional regulator
AMETH_RS15990	COG0183	Belongs to the thiolase family
AMETH_RS16070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS16075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS16080	COG1127	ABC transporter
AMETH_RS16135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS16145	COG1024	Enoyl-CoA hydratase
AMETH_RS16165	COG1024	Enoyl-CoA hydratase
AMETH_RS16260	COG1937	Protein conserved in bacteria
AMETH_RS16275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AMETH_RS16280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AMETH_RS16285	COG0156	8-amino-7-oxononanoate synthase activity
AMETH_RS16300	COG1846	Transcriptional regulator
AMETH_RS16380	COG2909	trisaccharide binding
AMETH_RS16380	COG2909	trisaccharide binding
AMETH_RS16400	COG3387	PFAM Glycoside hydrolase 15-related
AMETH_RS16420	COG0477	Major facilitator Superfamily
AMETH_RS16425	COG0628	permease
AMETH_RS16445	COG2326	polyphosphate kinase activity
AMETH_RS16450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMETH_RS16460	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMETH_RS16465	COG0483	inositol monophosphate 1-phosphatase activity
AMETH_RS16470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS16490	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS16520	COG0583	DNA-binding transcription factor activity
AMETH_RS16530	COG2814	Major facilitator Superfamily
AMETH_RS16550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMETH_RS16555	COG2755	lipolytic protein G-D-S-L family
AMETH_RS16585	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AMETH_RS16610	COG0640	Transcriptional regulator
AMETH_RS16630	COG4941	Belongs to the sigma-70 factor family
AMETH_RS16645	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMETH_RS16645	COG5479	isomerase activity
AMETH_RS16735	COG1846	Transcriptional regulator
AMETH_RS16740	COG0783	Belongs to the Dps family
AMETH_RS16750	COG1846	Transcriptional regulator
AMETH_RS16755	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AMETH_RS16775	COG2072	flavoprotein involved in K transport
AMETH_RS16840	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS16850	COG0656	L-ascorbic acid biosynthetic process
AMETH_RS16855	COG2814	Major facilitator Superfamily
AMETH_RS16895	COG0601	transmembrane transport
AMETH_RS16900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS16940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_RS17005	COG1309	transcriptional regulator
AMETH_RS17030	COG3383	formate dehydrogenase (NAD+) activity
AMETH_RS17030	COG0243	molybdopterin cofactor binding
AMETH_RS17035	COG0243	molybdopterin cofactor binding
AMETH_RS17035	COG3383	formate dehydrogenase (NAD+) activity
AMETH_RS17040	COG0437	4 iron, 4 sulfur cluster binding
AMETH_RS17060	COG1472	Belongs to the glycosyl hydrolase 3 family
AMETH_RS17070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS17090	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS17125	COG0667	Aldo Keto reductase
AMETH_RS17130	COG1968	undecaprenyl-diphosphatase activity
AMETH_RS17140	COG0339	signal peptide processing
AMETH_RS17155	COG0039	L-malate dehydrogenase activity
AMETH_RS17200	COG4166	transmembrane transport
AMETH_RS17205	COG0601	transmembrane transport
AMETH_RS17210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_RS17215	COG4172	Belongs to the ABC transporter superfamily
AMETH_RS17230	COG1619	proteins homologs of microcin C7 resistance protein MccF
AMETH_RS17235	COG4946	Tricorn protease homolog
AMETH_RS17235	COG1506	peptidase
AMETH_RS17235	COG0823	Involved in the tonB-independent uptake of proteins
AMETH_RS17250	COG1595	DNA-templated transcription, initiation
AMETH_RS17295	COG1733	regulation of RNA biosynthetic process
AMETH_RS17325	COG0477	Major facilitator Superfamily
AMETH_RS17340	COG1595	DNA-templated transcription, initiation
AMETH_RS17375	COG1051	belongs to the nudix hydrolase family
AMETH_RS17375	COG1056	cytidyltransferase-related domain
AMETH_RS17400	COG2860	membrane
AMETH_RS17410	COG2813	Specifically methylates the guanine in position
AMETH_RS17415	COG0583	DNA-binding transcription factor activity
AMETH_RS17430	COG2890	protein-(glutamine-N5) methyltransferase activity
AMETH_RS17445	COG1802	Transcriptional regulator
AMETH_RS17480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMETH_RS17510	COG1435	thymidine kinase activity
AMETH_RS17525	COG0463	Glycosyl transferase, family 2
AMETH_RS17535	COG1228	amidohydrolase
AMETH_RS17540	COG1509	lysine 2,3-aminomutase activity
AMETH_RS17615	COG4152	abc transporter atp-binding protein
AMETH_RS17660	COG4552	Acetyltransferase involved in intracellular survival and related
AMETH_RS17695	COG2378	regulation of single-species biofilm formation
AMETH_RS17700	COG2378	regulation of single-species biofilm formation
AMETH_RS17710	COG2409	Drug exporters of the RND superfamily
AMETH_RS17720	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMETH_RS17725	COG1357	PFAM Pentapeptide repeats (8 copies)
AMETH_RS17730	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMETH_RS17735	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AMETH_RS17775	COG1222	aaa ATPase
AMETH_RS17795	COG1994	Peptidase M50
AMETH_RS17795	COG0517	IMP dehydrogenase activity
AMETH_RS17820	COG4941	Belongs to the sigma-70 factor family
AMETH_RS17825	COG3795	YCII-related domain
AMETH_RS17840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AMETH_RS17845	COG0140	phosphoribosyl-ATP diphosphatase activity
AMETH_RS17855	COG0646	methionine synthase
AMETH_RS17855	COG1410	methionine synthase
AMETH_RS17870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AMETH_RS17885	COG0488	(ABC) transporter
AMETH_RS17890	COG0215	cysteine-tRNA ligase activity
AMETH_RS17965	COG1228	amidohydrolase
AMETH_RS18005	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_RS18010	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_RS18025	COG1129	ABC transporter
AMETH_RS18030	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS18040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMETH_RS18065	COG2409	Drug exporters of the RND superfamily
AMETH_RS18080	COG2159	amidohydrolase
AMETH_RS18090	COG2814	Major facilitator Superfamily
AMETH_RS18090	COG0477	Major facilitator Superfamily
AMETH_RS18120	COG0477	Major facilitator Superfamily
AMETH_RS18165	COG0009	L-threonylcarbamoyladenylate synthase
AMETH_RS18185	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_RS18200	COG2814	Major facilitator Superfamily
AMETH_RS18220	COG0243	molybdopterin cofactor binding
AMETH_RS18230	COG1063	alcohol dehydrogenase
AMETH_RS18235	COG0477	Major facilitator Superfamily
AMETH_RS18245	COG2072	flavoprotein involved in K transport
AMETH_RS18265	COG2144	transferase activity, transferring acyl groups
AMETH_RS18270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AMETH_RS18285	COG0492	ferredoxin-NADP+ reductase activity
AMETH_RS18310	COG1937	Protein conserved in bacteria
AMETH_RS18335	COG0589	response to stress
AMETH_RS18360	COG0022	dehydrogenase e1 component
AMETH_RS18390	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS18395	COG1024	Enoyl-CoA hydratase
AMETH_RS18400	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS18410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AMETH_RS18420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AMETH_RS18430	COG0129	dihydroxy-acid dehydratase activity
AMETH_RS18435	COG1053	succinate dehydrogenase
AMETH_RS18435	COG3976	FMN-binding domain protein
AMETH_RS18450	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AMETH_RS18455	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AMETH_RS18475	COG4585	Histidine kinase
AMETH_RS18480	COG2197	response regulator
AMETH_RS18495	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_RS18515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS18520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_RS18535	COG0513	Belongs to the DEAD box helicase family
AMETH_RS18545	COG0477	Major facilitator Superfamily
AMETH_RS18570	COG0668	transmembrane transport
AMETH_RS18700	COG1595	DNA-templated transcription, initiation
AMETH_RS18715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMETH_RS18720	COG1414	Transcriptional regulator
AMETH_RS18730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMETH_RS18735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMETH_RS18765	COG3104	oligopeptide transport
AMETH_RS18770	COG1228	amidohydrolase
AMETH_RS18790	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS18795	COG2814	Major facilitator Superfamily
AMETH_RS18820	COG0183	Belongs to the thiolase family
AMETH_RS18855	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS18865	COG0477	Major facilitator Superfamily
AMETH_RS18880	COG2197	response regulator
AMETH_RS18935	COG0589	response to stress
AMETH_RS18940	COG2814	Major facilitator Superfamily
AMETH_RS18945	COG1082	Xylose isomerase domain protein TIM barrel
AMETH_RS18950	COG0673	inositol 2-dehydrogenase activity
AMETH_RS18970	COG0714	Associated with various cellular activities
AMETH_RS18980	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AMETH_RS18995	COG0137	argininosuccinate synthase activity
AMETH_RS19025	COG1802	Transcriptional regulator
AMETH_RS19035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS19045	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AMETH_RS19065	COG2319	Wd-40 repeat
AMETH_RS19065	COG4249	Peptidase C14 caspase catalytic subunit p20
AMETH_RS19085	COG1414	Transcriptional regulator
AMETH_RS19095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_RS19100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS19105	COG2610	gluconate transmembrane transporter activity
AMETH_RS19115	COG3655	Transcriptional regulator
AMETH_RS19125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AMETH_RS19130	COG1116	anion transmembrane transporter activity
AMETH_RS19155	COG0596	Alpha beta hydrolase
AMETH_RS19235	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS19240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AMETH_RS19245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AMETH_RS19245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AMETH_RS19255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AMETH_RS19260	COG1492	cobalamin metabolic process
AMETH_RS19265	COG2205	protein histidine kinase activity
AMETH_RS19295	COG0671	phosphoesterase, PA-phosphatase related
AMETH_RS19305	COG0277	FAD linked oxidase domain protein
AMETH_RS19310	COG0277	FAD linked oxidase domain protein
AMETH_RS19315	COG0247	lactate metabolic process
AMETH_RS19320	COG1620	l-lactate permease
AMETH_RS19420	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS19440	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS19445	COG1063	alcohol dehydrogenase
AMETH_RS19455	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS19470	COG2801	Transposase and inactivated derivatives
AMETH_RS19515	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMETH_RS19515	COG2508	Transcriptional regulator
AMETH_RS19520	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_RS19540	COG4608	Belongs to the ABC transporter superfamily
AMETH_RS19545	COG0444	Belongs to the ABC transporter superfamily
AMETH_RS19550	COG0601	transmembrane transport
AMETH_RS19590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AMETH_RS19600	COG1201	RNA secondary structure unwinding
AMETH_RS19630	COG1609	Transcriptional regulator
AMETH_RS19635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_RS19640	COG0477	Major facilitator Superfamily
AMETH_RS19655	COG0564	pseudouridine synthase activity
AMETH_RS19665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS19670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS19680	COG0667	Aldo Keto reductase
AMETH_RS19685	COG0667	Aldo Keto reductase
AMETH_RS19710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_RS19720	COG0747	negative chemotaxis
AMETH_RS19725	COG0583	DNA-binding transcription factor activity
AMETH_RS19750	COG0596	Alpha beta hydrolase
AMETH_RS19755	COG1335	isochorismatase
AMETH_RS19780	COG0477	Major facilitator Superfamily
AMETH_RS19790	COG3473	Maleate cis-trans isomerase
AMETH_RS19795	COG2309	aminopeptidase activity
AMETH_RS19815	COG0596	Alpha beta hydrolase
AMETH_RS19825	COG0697	spore germination
AMETH_RS19830	COG0583	DNA-binding transcription factor activity
AMETH_RS19865	COG3665	Urea carboxylase-associated protein
AMETH_RS19870	COG3953	SLT domain
AMETH_RS19870	COG5280	Phage tail tape measure protein TP901
AMETH_RS19885	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_RS19940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_RS19975	COG0740	serine-type endopeptidase activity
AMETH_RS19980	COG2197	response regulator
AMETH_RS20000	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AMETH_RS20010	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS20015	COG0477	Major facilitator Superfamily
AMETH_RS20025	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS20030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS20035	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS20055	COG1063	alcohol dehydrogenase
AMETH_RS20075	COG2318	DinB family
AMETH_RS20080	COG1796	DNA polymerase
AMETH_RS20080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AMETH_RS20110	COG5650	phosphatidylinositol metabolic process
AMETH_RS20115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AMETH_RS20120	COG0667	Aldo Keto reductase
AMETH_RS20150	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS20155	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS20160	COG1309	transcriptional regulator
AMETH_RS20165	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS20170	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS20175	COG1309	transcriptional regulator
AMETH_RS20180	COG0596	Alpha beta hydrolase
AMETH_RS20215	COG1309	transcriptional regulator
AMETH_RS20230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMETH_RS20235	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS20250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMETH_RS20250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_RS20255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_RS20285	COG1316	TRANSCRIPTIONal
AMETH_RS20295	COG4821	SIS domain
AMETH_RS20300	COG1132	(ABC) transporter
AMETH_RS20315	COG0488	(ABC) transporter
AMETH_RS20320	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AMETH_RS20325	COG2203	Gaf domain
AMETH_RS20325	COG4251	negative regulation of phosphorylation
AMETH_RS20325	COG3706	GGDEF domain
AMETH_RS20325	COG5001	Diguanylate cyclase
AMETH_RS20335	COG2151	metal-sulfur cluster biosynthetic enzyme
AMETH_RS20340	COG0822	iron-sulfur transferase activity
AMETH_RS20350	COG0396	ATPase activity
AMETH_RS20375	COG1131	(ABC) transporter
AMETH_RS20415	COG1657	PFAM Prenyltransferase squalene oxidase
AMETH_RS20425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AMETH_RS20465	COG0697	spore germination
AMETH_RS20470	COG0300	oxidoreductase activity
AMETH_RS20480	COG3973	AAA domain
AMETH_RS20485	COG0109	protoheme IX farnesyltransferase activity
AMETH_RS20495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AMETH_RS20500	COG0166	Belongs to the GPI family
AMETH_RS20515	COG0363	glucosamine-6-phosphate deaminase activity
AMETH_RS20525	COG4585	Histidine kinase
AMETH_RS20540	COG0149	triose-phosphate isomerase activity
AMETH_RS20545	COG0126	phosphoglycerate kinase activity
AMETH_RS20550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AMETH_RS20595	COG1846	Transcriptional regulator
AMETH_RS20610	COG0463	Glycosyl transferase, family 2
AMETH_RS20635	COG1481	regulation of sporulation
AMETH_RS20645	COG1660	Displays ATPase and GTPase activities
AMETH_RS20650	COG0322	excinuclease ABC activity
AMETH_RS20665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AMETH_RS20670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS20670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS20695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AMETH_RS20715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AMETH_RS20725	COG1758	RNA polymerase activity
AMETH_RS20730	COG0194	GDP metabolic process
AMETH_RS20740	COG0284	orotidine-5'-phosphate decarboxylase activity
AMETH_RS20750	COG0505	Belongs to the CarA family
AMETH_RS20765	COG0540	Belongs to the ATCase OTCase family
AMETH_RS20770	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AMETH_RS20780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AMETH_RS20785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AMETH_RS20805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AMETH_RS20810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AMETH_RS20815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AMETH_RS20820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AMETH_RS20825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AMETH_RS20830	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AMETH_RS20860	COG2190	(PTS) system
AMETH_RS20865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AMETH_RS20870	COG2188	Transcriptional regulator
AMETH_RS20875	COG1263	PTS System
AMETH_RS20880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMETH_RS20885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMETH_RS20905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AMETH_RS20920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AMETH_RS20960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AMETH_RS20985	COG0156	8-amino-7-oxononanoate synthase activity
AMETH_RS21005	COG0702	epimerase
AMETH_RS21010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_RS21015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_RS21025	COG0386	Belongs to the glutathione peroxidase family
AMETH_RS21045	COG1252	NADH dehydrogenase
AMETH_RS21060	COG1473	amidohydrolase
AMETH_RS21090	COG1414	Transcriptional regulator
AMETH_RS21120	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS21130	COG2814	Major facilitator Superfamily
AMETH_RS21180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMETH_RS21185	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS21225	COG2197	response regulator
AMETH_RS21240	COG0439	Biotin carboxylase
AMETH_RS21250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_RS21260	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_RS21310	COG0477	Major facilitator Superfamily
AMETH_RS21320	COG0583	DNA-binding transcription factor activity
AMETH_RS21325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMETH_RS21330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMETH_RS21335	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_RS21340	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS21345	COG0431	NADPH-dependent FMN reductase
AMETH_RS21370	COG1278	Cold shock
AMETH_RS21375	COG1940	carbohydrate kinase activity
AMETH_RS21380	COG0673	inositol 2-dehydrogenase activity
AMETH_RS21400	COG0590	tRNA wobble adenosine to inosine editing
AMETH_RS21410	COG1522	sequence-specific DNA binding
AMETH_RS21445	COG2376	Dihydroxyacetone kinase
AMETH_RS21450	COG1414	Transcriptional regulator
AMETH_RS21480	COG0477	Major facilitator Superfamily
AMETH_RS21505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_RS21535	COG0542	response to heat
AMETH_RS21555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS21580	COG2226	methyltransferase
AMETH_RS21600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AMETH_RS21605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_RS21620	COG0459	protein refolding
AMETH_RS21650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_RS21675	COG0640	Transcriptional regulator
AMETH_RS21680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AMETH_RS21745	COG2175	clavaminate synthase activity
AMETH_RS21750	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
AMETH_RS21770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AMETH_RS21785	COG0726	polysaccharide deacetylase
AMETH_RS21790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMETH_RS21830	COG2272	Belongs to the type-B carboxylesterase lipase family
AMETH_RS21840	COG2018	Roadblock/LC7 domain
AMETH_RS21890	COG4941	Belongs to the sigma-70 factor family
AMETH_RS21895	COG3795	YCII-related domain
AMETH_RS21900	COG0135	phosphoribosylanthranilate isomerase activity
AMETH_RS21935	COG0463	Glycosyl transferase, family 2
AMETH_RS21980	COG1309	transcriptional regulator
AMETH_RS21990	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS22010	COG0596	Alpha beta hydrolase
AMETH_RS22030	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS22035	COG3622	Belongs to the hyi family
AMETH_RS22050	COG3511	phospholipase C
AMETH_RS22060	COG2018	Roadblock/LC7 domain
AMETH_RS22075	COG3033	Beta-eliminating lyase
AMETH_RS22090	COG1024	Enoyl-CoA hydratase
AMETH_RS22095	COG3012	SEC-C Motif Domain Protein
AMETH_RS22130	COG2271	Major facilitator Superfamily
AMETH_RS22145	COG1842	Phage shock protein A
AMETH_RS22175	COG2072	flavoprotein involved in K transport
AMETH_RS22210	COG3835	regulator
AMETH_RS22290	COG2226	methyltransferase
AMETH_RS22310	COG0426	domain, Protein
AMETH_RS22310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMETH_RS22315	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS22325	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS22330	COG1024	Enoyl-CoA hydratase
AMETH_RS22335	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS22340	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS22350	COG0183	Belongs to the thiolase family
AMETH_RS22370	COG1024	Enoyl-CoA hydratase
AMETH_RS22375	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS22395	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS22405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMETH_RS22440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AMETH_RS22445	COG4638	Rieske (2fe-2S)
AMETH_RS22450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMETH_RS22485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AMETH_RS22490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AMETH_RS22500	COG1760	l-serine dehydratase
AMETH_RS22510	COG1414	Transcriptional regulator
AMETH_RS22515	COG2146	nitrite reductase [NAD(P)H] activity
AMETH_RS22520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_RS22525	COG3226	Transcriptional regulator
AMETH_RS22530	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS22555	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS22560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS22570	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS22585	COG0477	Major facilitator Superfamily
AMETH_RS22605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMETH_RS22610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AMETH_RS22625	COG1494	fructose-1,6-bisphosphatase
AMETH_RS22680	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AMETH_RS22700	COG3588	fructose-bisphosphate aldolase
AMETH_RS22705	COG0583	DNA-binding transcription factor activity
AMETH_RS22715	COG0535	radical SAM domain protein
AMETH_RS22730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AMETH_RS22765	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS22770	COG1024	Enoyl-CoA hydratase
AMETH_RS22785	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS22790	COG1024	Enoyl-CoA hydratase
AMETH_RS22795	COG0183	Belongs to the thiolase family
AMETH_RS22805	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS22810	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS22825	COG3293	Transposase
AMETH_RS22845	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS22900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AMETH_RS22925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS22930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS22935	COG1309	transcriptional regulator
AMETH_RS22950	COG3284	Transcriptional regulator
AMETH_RS22960	COG1063	alcohol dehydrogenase
AMETH_RS22970	COG0477	Major facilitator Superfamily
AMETH_RS22975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AMETH_RS22985	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_RS23000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_RS23015	COG0477	Major facilitator Superfamily
AMETH_RS23020	COG1609	Transcriptional regulator
AMETH_RS23025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AMETH_RS23035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AMETH_RS23090	COG0640	Transcriptional regulator
AMETH_RS23095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS23095	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS23105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_RS23110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS23125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS23155	COG2197	response regulator
AMETH_RS23185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS23190	COG1024	Enoyl-CoA hydratase
AMETH_RS23210	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS23215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS23215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AMETH_RS23225	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AMETH_RS23260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS23305	COG2271	Major facilitator Superfamily
AMETH_RS23310	COG1349	DNA-binding transcription factor activity
AMETH_RS23315	COG1063	alcohol dehydrogenase
AMETH_RS23320	COG1830	Aldolase
AMETH_RS23335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AMETH_RS23340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AMETH_RS23345	COG0277	FAD linked oxidase domain protein
AMETH_RS23430	COG3237	CsbD-like
AMETH_RS23445	COG1556	Lactate utilization protein
AMETH_RS23450	COG1139	Iron-sulfur cluster binding protein
AMETH_RS23455	COG0247	lactate metabolic process
AMETH_RS23465	COG2186	Transcriptional regulator
AMETH_RS23470	COG1802	Transcriptional regulator
AMETH_RS23475	COG4770	biotin carboxylase activity
AMETH_RS23495	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS23500	COG1024	Enoyl-CoA hydratase
AMETH_RS23505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS23515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AMETH_RS23610	COG5650	phosphatidylinositol metabolic process
AMETH_RS23615	COG0174	glutamine synthetase
AMETH_RS23650	COG0640	Transcriptional regulator
AMETH_RS23665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AMETH_RS23680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AMETH_RS23690	COG1793	dna ligase
AMETH_RS23710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS23740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AMETH_RS23755	COG3220	belongs to the UPF0276 family
AMETH_RS23770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS23775	COG3253	May function as heme-dependent peroxidase
AMETH_RS23785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AMETH_RS23795	COG2197	response regulator
AMETH_RS23805	COG0183	Belongs to the thiolase family
AMETH_RS23810	COG1024	Enoyl-CoA hydratase
AMETH_RS23810	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_RS23820	COG0154	amidase activity
AMETH_RS23840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS23845	COG1846	Transcriptional regulator
AMETH_RS23850	COG0656	L-ascorbic acid biosynthetic process
AMETH_RS23855	COG2205	protein histidine kinase activity
AMETH_RS23860	COG0745	RESPONSE REGULATOR receiver
AMETH_RS23910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AMETH_RS23925	COG1053	succinate dehydrogenase
AMETH_RS23930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AMETH_RS23940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AMETH_RS23945	COG0531	amino acid
AMETH_RS23950	COG0569	domain protein
AMETH_RS23980	COG0756	dUTP diphosphatase activity
AMETH_RS24000	COG0483	inositol monophosphate 1-phosphatase activity
AMETH_RS24015	COG0531	amino acid
AMETH_RS24055	COG1942	4-Oxalocrotonate Tautomerase
AMETH_RS24065	COG2313	pseudouridylate synthase activity
AMETH_RS24080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AMETH_RS24085	COG2318	DinB family
AMETH_RS24100	COG1490	D-aminoacyl-tRNA deacylase activity
AMETH_RS24140	COG2070	2-Nitropropane dioxygenase
AMETH_RS24190	COG2124	cytochrome p450
AMETH_RS24195	COG0183	Belongs to the thiolase family
AMETH_RS24205	COG2226	methyltransferase
AMETH_RS24220	COG1733	regulation of RNA biosynthetic process
AMETH_RS24225	COG0702	epimerase
AMETH_RS24240	COG1473	amidohydrolase
AMETH_RS24245	COG2814	Major facilitator Superfamily
AMETH_RS24250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AMETH_RS24255	COG0346	lactoylglutathione lyase activity
AMETH_RS24260	COG2267	carboxylic ester hydrolase activity
AMETH_RS24265	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS24275	COG1053	succinate dehydrogenase
AMETH_RS24295	COG2030	dehydratase
AMETH_RS24320	COG2030	dehydratase
AMETH_RS24325	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS24330	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS24335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AMETH_RS24340	COG0657	acetylesterase activity
AMETH_RS24345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AMETH_RS24350	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS24355	COG1309	transcriptional regulator
AMETH_RS24380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMETH_RS24385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMETH_RS24395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMETH_RS24395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AMETH_RS24395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AMETH_RS24405	COG1349	DNA-binding transcription factor activity
AMETH_RS24410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMETH_RS24410	COG1703	isobutyryl-CoA mutase activity
AMETH_RS24410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AMETH_RS24425	COG2018	Roadblock/LC7 domain
AMETH_RS24440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_RS24450	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AMETH_RS24480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS24500	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS24505	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMETH_RS24505	COG1672	PFAM Archaeal ATPase
AMETH_RS24525	COG1946	Acyl-CoA thioesterase
AMETH_RS24535	COG2226	methyltransferase
AMETH_RS24565	COG0204	Acyl-transferase
AMETH_RS24580	COG1929	Belongs to the glycerate kinase type-1 family
AMETH_RS24585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_RS24610	COG2890	protein-(glutamine-N5) methyltransferase activity
AMETH_RS24625	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMETH_RS24630	COG0723	plastoquinol--plastocyanin reductase activity
AMETH_RS24665	COG1573	uracil-dna glycosylase
AMETH_RS24685	COG1278	Cold shock
AMETH_RS24700	COG2080	2 iron, 2 sulfur cluster binding
AMETH_RS24705	COG2010	Cytochrome c
AMETH_RS24705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AMETH_RS24730	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMETH_RS24730	COG1902	pentaerythritol trinitrate reductase activity
AMETH_RS24735	COG1902	pentaerythritol trinitrate reductase activity
AMETH_RS24735	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMETH_RS24745	COG0535	radical SAM domain protein
AMETH_RS24765	COG1940	carbohydrate kinase activity
AMETH_RS24775	COG0003	Pfam Anion-transporting ATPase
AMETH_RS24795	COG1022	Amp-dependent synthetase and ligase
AMETH_RS24850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS24855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS24865	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS24870	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS24880	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS24885	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS24890	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS24910	COG0123	including yeast histone deacetylase and acetoin utilization protein
AMETH_RS24920	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AMETH_RS24925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AMETH_RS24945	COG0517	IMP dehydrogenase activity
AMETH_RS24945	COG0516	GMP reductase activity
AMETH_RS24960	COG1505	serine-type exopeptidase activity
AMETH_RS24980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_RS24985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AMETH_RS24995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AMETH_RS25005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AMETH_RS25030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AMETH_RS25040	COG1196	nuclear chromosome segregation
AMETH_RS25055	COG2814	Major facilitator Superfamily
AMETH_RS25060	COG0583	DNA-binding transcription factor activity
AMETH_RS25070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AMETH_RS25080	COG1126	abc transporter atp-binding protein
AMETH_RS25090	COG0765	amino acid transport
AMETH_RS25095	COG0765	amino acid transport
AMETH_RS25105	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AMETH_RS25110	COG3842	ATPase activity
AMETH_RS25120	COG1175	transmembrane transport
AMETH_RS25130	COG1940	carbohydrate kinase activity
AMETH_RS25145	COG1053	succinate dehydrogenase
AMETH_RS25165	COG0800	Aldolase
AMETH_RS25175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_RS25195	COG2137	regulation of response to DNA damage stimulus
AMETH_RS25200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AMETH_RS25210	COG0443	Heat shock 70 kDa protein
AMETH_RS25215	COG1201	RNA secondary structure unwinding
AMETH_RS25220	COG0242	peptide deformylase activity
AMETH_RS25250	COG5504	Zn-dependent protease
AMETH_RS25270	COG0697	spore germination
AMETH_RS25290	COG0583	DNA-binding transcription factor activity
AMETH_RS25305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AMETH_RS25310	COG1396	sequence-specific DNA binding
AMETH_RS25325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_RS25330	COG0142	geranyltranstransferase activity
AMETH_RS25345	COG0515	serine threonine protein kinase
AMETH_RS25345	COG2815	serine threonine protein kinase
AMETH_RS25360	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AMETH_RS25385	COG0069	glutamate synthase activity
AMETH_RS25385	COG0067	glutamate synthase
AMETH_RS25385	COG0070	glutamate synthase
AMETH_RS25395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS25400	COG1120	ATPase activity
AMETH_RS25415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AMETH_RS25435	COG0159	tryptophan synthase activity
AMETH_RS25440	COG0133	tryptophan synthase activity
AMETH_RS25445	COG0134	indole-3-glycerol-phosphate synthase activity
AMETH_RS25455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AMETH_RS25465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AMETH_RS25470	COG0107	imidazoleglycerol-phosphate synthase activity
AMETH_RS25485	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AMETH_RS25490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AMETH_RS25505	COG3959	Transketolase, thiamine diphosphate binding domain
AMETH_RS25515	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AMETH_RS25525	COG1309	transcriptional regulator
AMETH_RS25530	COG2409	Drug exporters of the RND superfamily
AMETH_RS25535	COG0131	Imidazoleglycerol-phosphate dehydratase
AMETH_RS25540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AMETH_RS25545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AMETH_RS25555	COG2197	response regulator
AMETH_RS25570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMETH_RS25570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AMETH_RS25575	COG4585	Histidine kinase
AMETH_RS25585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AMETH_RS25615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AMETH_RS25620	COG0659	secondary active sulfate transmembrane transporter activity
AMETH_RS25625	COG0789	Transcriptional regulator
AMETH_RS25635	COG2124	cytochrome p450
AMETH_RS25650	COG0438	transferase activity, transferring glycosyl groups
AMETH_RS25680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AMETH_RS25690	COG2010	Cytochrome c
AMETH_RS25695	COG1845	cytochrome c oxidase, subunit III
AMETH_RS25710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AMETH_RS25720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AMETH_RS25730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AMETH_RS25745	COG0667	Aldo Keto reductase
AMETH_RS25750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AMETH_RS25760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AMETH_RS25785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AMETH_RS25790	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_RS25800	COG1090	epimerase
AMETH_RS25810	COG0321	lipoyl(octanoyl) transferase activity
AMETH_RS25835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AMETH_RS25840	COG0586	Pfam SNARE associated Golgi protein
AMETH_RS25855	COG1752	Esterase of the alpha-beta hydrolase superfamily
AMETH_RS25860	COG1376	ErfK ybiS ycfS ynhG family protein
AMETH_RS25865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMETH_RS25880	COG0587	DNA-directed DNA polymerase activity
AMETH_RS25885	COG1309	transcriptional regulator
AMETH_RS25900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AMETH_RS25940	COG1397	ADP-ribosylglycohydrolase
AMETH_RS25965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AMETH_RS25985	COG1620	l-lactate permease
AMETH_RS25990	COG3201	nicotinamide mononucleotide transporter
AMETH_RS26000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AMETH_RS26005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AMETH_RS26010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AMETH_RS26050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS26055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS26075	COG0442	prolyl-tRNA aminoacylation
AMETH_RS26085	COG1414	Transcriptional regulator
AMETH_RS26105	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AMETH_RS26125	COG2186	Transcriptional regulator
AMETH_RS26130	COG0028	Belongs to the TPP enzyme family
AMETH_RS26135	COG1742	UPF0060 membrane protein
AMETH_RS26145	COG1946	Acyl-CoA thioesterase
AMETH_RS26185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_RS26190	COG2151	metal-sulfur cluster biosynthetic enzyme
AMETH_RS26195	COG3396	Phenylacetate-CoA oxygenase
AMETH_RS26200	COG3460	Phenylacetate-CoA oxygenase
AMETH_RS26205	COG3396	Phenylacetate-CoA oxygenase
AMETH_RS26210	COG2030	dehydratase
AMETH_RS26210	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS26230	COG1309	transcriptional regulator
AMETH_RS26235	COG2814	Major facilitator Superfamily
AMETH_RS26245	COG1690	Belongs to the RtcB family
AMETH_RS26250	COG1522	sequence-specific DNA binding
AMETH_RS26275	COG2267	carboxylic ester hydrolase activity
AMETH_RS26280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS26285	COG1414	Transcriptional regulator
AMETH_RS26330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_RS26335	COG0697	spore germination
AMETH_RS26340	COG1793	dna ligase
AMETH_RS26340	COG3285	dna ligase
AMETH_RS26345	COG1672	PFAM Archaeal ATPase
AMETH_RS26345	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMETH_RS26350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AMETH_RS26365	COG4941	Belongs to the sigma-70 factor family
AMETH_RS26385	COG0242	peptide deformylase activity
AMETH_RS26425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AMETH_RS26435	COG2315	Protein conserved in bacteria
AMETH_RS26465	COG1846	Transcriptional regulator
AMETH_RS26475	COG0477	Major facilitator Superfamily
AMETH_RS26495	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_RS26540	COG0456	acetyltransferase
AMETH_RS26555	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMETH_RS26560	COG1414	Transcriptional regulator
AMETH_RS26565	COG2072	flavoprotein involved in K transport
AMETH_RS26605	COG3275	phosphorelay sensor kinase activity
AMETH_RS26610	COG3279	Response regulator of the LytR AlgR family
AMETH_RS26620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_RS26630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AMETH_RS26655	COG3458	cephalosporin-C deacetylase activity
AMETH_RS26660	COG2186	Transcriptional regulator
AMETH_RS26665	COG0747	negative chemotaxis
AMETH_RS26685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_RS26710	COG1733	regulation of RNA biosynthetic process
AMETH_RS26725	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS26745	COG1609	Transcriptional regulator
AMETH_RS26810	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS26825	COG1643	Atp-dependent helicase
AMETH_RS26845	COG0475	glutathione-regulated potassium exporter activity
AMETH_RS26855	COG2814	Major facilitator Superfamily
AMETH_RS26890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_RS26905	COG1120	ATPase activity
AMETH_RS26910	COG4122	O-methyltransferase activity
AMETH_RS26920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMETH_RS26925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMETH_RS26925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AMETH_RS26935	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS26940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AMETH_RS27000	COG2226	methyltransferase
AMETH_RS27005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AMETH_RS27025	COG1414	Transcriptional regulator
AMETH_RS27030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AMETH_RS27035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMETH_RS27045	COG3485	protocatechuate 3,4-dioxygenase
AMETH_RS27050	COG3485	protocatechuate 3,4-dioxygenase
AMETH_RS27055	COG0183	Belongs to the thiolase family
AMETH_RS27060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AMETH_RS27065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AMETH_RS27070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AMETH_RS27125	COG3268	Saccharopine dehydrogenase
AMETH_RS27170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AMETH_RS27180	COG3483	tryptophan 2,3-dioxygenase activity
AMETH_RS27185	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AMETH_RS27190	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AMETH_RS27190	COG0235	Class ii aldolase
AMETH_RS27200	COG2197	response regulator
AMETH_RS27205	COG2197	response regulator
AMETH_RS27210	COG0410	ABC transporter
AMETH_RS27215	COG0411	ABC transporter
AMETH_RS27220	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS27225	COG0559	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS27250	COG3971	2-oxopent-4-enoate hydratase activity
AMETH_RS27270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMETH_RS27275	COG0069	glutamate synthase activity
AMETH_RS27275	COG0070	glutamate synthase
AMETH_RS27275	COG0067	glutamate synthase
AMETH_RS27300	COG1349	DNA-binding transcription factor activity
AMETH_RS27305	COG1492	cobalamin metabolic process
AMETH_RS27310	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AMETH_RS27325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AMETH_RS27330	COG2814	Major facilitator Superfamily
AMETH_RS27345	COG1797	cobyrinic acid a,c-diamide synthase activity
AMETH_RS27380	COG0778	Nitroreductase
AMETH_RS27400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AMETH_RS27415	COG0037	tRNA processing
AMETH_RS27425	COG1309	transcriptional regulator
AMETH_RS27460	COG1024	Enoyl-CoA hydratase
AMETH_RS27470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMETH_RS27495	COG1116	anion transmembrane transporter activity
AMETH_RS27505	COG1476	TRANSCRIPTIONal
AMETH_RS27515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AMETH_RS27535	COG3293	Transposase
AMETH_RS27550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AMETH_RS27575	COG2183	response to ionizing radiation
AMETH_RS27595	COG1522	sequence-specific DNA binding
AMETH_RS27615	COG0431	NADPH-dependent FMN reductase
AMETH_RS27625	COG0277	FAD linked oxidase domain protein
AMETH_RS27645	COG2815	serine threonine protein kinase
AMETH_RS27645	COG0515	serine threonine protein kinase
AMETH_RS27675	COG1119	ATPase activity
AMETH_RS27715	COG0058	SHG alpha-glucan phosphorylase activity
AMETH_RS27725	COG1846	Transcriptional regulator
AMETH_RS27745	COG0583	DNA-binding transcription factor activity
AMETH_RS27750	COG2409	Drug exporters of the RND superfamily
AMETH_RS27755	COG1609	Transcriptional regulator
AMETH_RS27770	COG1172	Belongs to the binding-protein-dependent transport system permease family
AMETH_RS27775	COG1879	ABC-type sugar transport system periplasmic component
AMETH_RS27800	COG0183	Belongs to the thiolase family
AMETH_RS27835	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AMETH_RS27840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AMETH_RS27860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMETH_RS27865	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AMETH_RS27875	COG1376	ErfK ybiS ycfS ynhG family protein
AMETH_RS27885	COG1819	glycosyl
AMETH_RS27915	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AMETH_RS27930	COG2197	response regulator
AMETH_RS27965	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS27975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_RS27990	COG2226	methyltransferase
AMETH_RS28000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AMETH_RS28010	COG1414	Transcriptional regulator
AMETH_RS28030	COG1216	Glycosyl transferase, family 2
AMETH_RS28035	COG2205	protein histidine kinase activity
AMETH_RS28055	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_RS28060	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_RS28065	COG2172	sigma factor antagonist activity
AMETH_RS28085	COG1366	Belongs to the anti-sigma-factor antagonist family
AMETH_RS28155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AMETH_RS28155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AMETH_RS28245	COG0366	Alpha amylase catalytic
AMETH_RS28265	COG0514	ATP-dependent DNA helicase (RecQ)
AMETH_RS28275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AMETH_RS28310	COG3844	kynureninase activity
AMETH_RS28320	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS28325	COG2814	Major facilitator Superfamily
AMETH_RS28340	COG1316	TRANSCRIPTIONal
AMETH_RS28355	COG1309	transcriptional regulator
AMETH_RS28410	COG1595	DNA-templated transcription, initiation
AMETH_RS28420	COG1082	Xylose isomerase domain protein TIM barrel
AMETH_RS28420	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AMETH_RS28425	COG1309	transcriptional regulator
AMETH_RS28430	COG0477	Major facilitator Superfamily
AMETH_RS28435	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS28455	COG0477	Major facilitator Superfamily
AMETH_RS28455	COG2814	Major facilitator Superfamily
AMETH_RS28475	COG0484	heat shock protein binding
AMETH_RS28490	COG3340	Belongs to the peptidase S51 family
AMETH_RS28510	COG1414	Transcriptional regulator
AMETH_RS28525	COG0596	Alpha beta hydrolase
AMETH_RS28535	COG0655	NAD(P)H dehydrogenase (quinone) activity
AMETH_RS28540	COG1063	alcohol dehydrogenase
AMETH_RS28560	COG0435	Glutathione S-transferase
AMETH_RS28575	COG0154	amidase activity
AMETH_RS28605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AMETH_RS28610	COG0473	3-isopropylmalate dehydrogenase activity
AMETH_RS28620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AMETH_RS28635	COG0028	Belongs to the TPP enzyme family
AMETH_RS28640	COG1024	Enoyl-CoA hydratase
AMETH_RS28640	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_RS28645	COG0183	Belongs to the thiolase family
AMETH_RS28650	COG1309	transcriptional regulator
AMETH_RS28660	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS28665	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS28670	COG0277	FAD linked oxidase domain protein
AMETH_RS28690	COG0640	Transcriptional regulator
AMETH_RS28695	COG0346	lactoylglutathione lyase activity
AMETH_RS28725	COG1191	sigma factor activity
AMETH_RS28730	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS28740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AMETH_RS28775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AMETH_RS28790	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AMETH_RS28790	COG2508	Transcriptional regulator
AMETH_RS28820	COG1132	(ABC) transporter
AMETH_RS28825	COG0277	FAD linked oxidase domain protein
AMETH_RS28855	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_RS28855	COG0567	Dehydrogenase, E1 component
AMETH_RS28870	COG0281	malic enzyme
AMETH_RS28875	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AMETH_RS28900	COG0406	alpha-ribazole phosphatase activity
AMETH_RS28905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AMETH_RS28920	COG1597	lipid kinase activity
AMETH_RS28935	COG5662	AntiSigma factor
AMETH_RS28945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AMETH_RS28955	COG2135	peptidase activity
AMETH_RS28995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_RS29000	COG1011	Hydrolase
AMETH_RS29010	COG0653	protein targeting
AMETH_RS29015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AMETH_RS29025	COG5401	PFAM Sporulation and spore germination
AMETH_RS29030	COG5002	protein histidine kinase activity
AMETH_RS29030	COG5000	phosphorelay sensor kinase activity
AMETH_RS29035	COG0745	RESPONSE REGULATOR receiver
AMETH_RS29065	COG0531	amino acid
AMETH_RS29085	COG1482	cell wall glycoprotein biosynthetic process
AMETH_RS29095	COG2835	tetraacyldisaccharide 4'-kinase activity
AMETH_RS29100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AMETH_RS29125	COG1994	Peptidase M50
AMETH_RS29140	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_RS29145	COG0747	negative chemotaxis
AMETH_RS29165	COG4608	Belongs to the ABC transporter superfamily
AMETH_RS29170	COG0747	negative chemotaxis
AMETH_RS29175	COG1217	gtp-binding protein TYPA
AMETH_RS29185	COG0180	Tryptophanyl-tRNA synthetase
AMETH_RS29200	COG0745	RESPONSE REGULATOR receiver
AMETH_RS29210	COG1131	(ABC) transporter
AMETH_RS29220	COG3842	ATPase activity
AMETH_RS29225	COG4149	molybdate abc transporter
AMETH_RS29235	COG2154	pterin-4-alpha-carbinolamine dehydratase
AMETH_RS29250	COG0012	GTP binding
AMETH_RS29265	COG0419	ATPase involved in DNA repair
AMETH_RS29270	COG0420	3'-5' exonuclease activity
AMETH_RS29285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AMETH_RS29295	COG1570	exodeoxyribonuclease VII activity
AMETH_RS29305	COG1722	exodeoxyribonuclease VII activity
AMETH_RS29320	COG0492	ferredoxin-NADP+ reductase activity
AMETH_RS29325	COG0114	fumarate hydratase activity
AMETH_RS29350	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AMETH_RS29360	COG0697	spore germination
AMETH_RS29365	COG1793	dna ligase
AMETH_RS29375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS29380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AMETH_RS29400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AMETH_RS29435	COG1331	Highly conserved protein containing a thioredoxin domain
AMETH_RS29445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_RS29455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AMETH_RS29460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AMETH_RS29470	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AMETH_RS29480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AMETH_RS29515	COG0183	Belongs to the thiolase family
AMETH_RS29545	COG0642	Histidine kinase
AMETH_RS29580	COG3707	response regulator
AMETH_RS29645	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS29700	COG0582	viral genome integration into host DNA
AMETH_RS29710	COG1252	NADH dehydrogenase
AMETH_RS29755	COG0148	phosphopyruvate hydratase activity
AMETH_RS29775	COG0672	)-iron permease
AMETH_RS29780	COG2822	iron ion transport
AMETH_RS29785	COG2837	iron assimilation
AMETH_RS29790	COG3956	TIGRFAM MazG family protein
AMETH_RS29810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS29830	COG2133	pyrroloquinoline quinone binding
AMETH_RS29835	COG1113	amino acid transport
AMETH_RS29850	COG2076	Multidrug Resistance protein
AMETH_RS29870	COG1309	transcriptional regulator
AMETH_RS29890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AMETH_RS29915	COG0193	aminoacyl-tRNA hydrolase activity
AMETH_RS29925	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS29940	COG1309	transcriptional regulator
AMETH_RS29945	COG0488	(ABC) transporter
AMETH_RS29950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AMETH_RS29955	COG1309	transcriptional regulator
AMETH_RS29965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AMETH_RS29970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AMETH_RS29975	COG3583	domain protein
AMETH_RS29980	COG0084	hydrolase, TatD family'
AMETH_RS29985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AMETH_RS30015	COG0577	efflux transmembrane transporter activity
AMETH_RS30015	COG1136	(ABC) transporter
AMETH_RS30060	COG2226	methyltransferase
AMETH_RS30065	COG0515	serine threonine protein kinase
AMETH_RS30115	COG2217	Heavy metal translocating P-type atpase
AMETH_RS30120	COG0640	Transcriptional regulator
AMETH_RS30175	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS30185	COG0446	pyridine nucleotide-disulphide oxidoreductase
AMETH_RS30185	COG1902	pentaerythritol trinitrate reductase activity
AMETH_RS30190	COG0531	amino acid
AMETH_RS30200	COG4638	Rieske (2fe-2S)
AMETH_RS30210	COG3619	membrane
AMETH_RS30215	COG0477	Major facilitator Superfamily
AMETH_RS30245	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AMETH_RS30260	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS30325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AMETH_RS30330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AMETH_RS30345	COG0521	Mo-molybdopterin cofactor biosynthetic process
AMETH_RS30345	COG0315	cyclic pyranopterin monophosphate synthase activity
AMETH_RS30350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AMETH_RS30360	COG1349	DNA-binding transcription factor activity
AMETH_RS30365	COG2205	protein histidine kinase activity
AMETH_RS30370	COG0745	RESPONSE REGULATOR receiver
AMETH_RS30375	COG2197	response regulator
AMETH_RS30465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AMETH_RS30490	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS30510	COG4191	Histidine kinase
AMETH_RS30515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_RS30520	COG0492	ferredoxin-NADP+ reductase activity
AMETH_RS30525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AMETH_RS30530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_RS30540	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AMETH_RS30550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AMETH_RS30555	COG0022	dehydrogenase e1 component
AMETH_RS30560	COG0508	dehydrogenase complex catalyzes the overall conversion of
AMETH_RS30575	COG2151	metal-sulfur cluster biosynthetic enzyme
AMETH_RS30605	COG3350	monooxygenase activity
AMETH_RS30630	COG2207	Transcriptional regulator
AMETH_RS30635	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_RS30640	COG1349	DNA-binding transcription factor activity
AMETH_RS30645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_RS30675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AMETH_RS30700	COG1940	carbohydrate kinase activity
AMETH_RS30720	COG0395	ABC-type sugar transport system, permease component
AMETH_RS30730	COG1653	transport
AMETH_RS30735	COG0673	inositol 2-dehydrogenase activity
AMETH_RS30760	COG0179	Fumarylacetoacetate (FAA) hydrolase
AMETH_RS30780	COG0387	Pfam Sodium calcium exchanger
AMETH_RS30790	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS30835	COG0668	transmembrane transport
AMETH_RS30840	COG1234	tRNA 3'-trailer cleavage
AMETH_RS30850	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS30855	COG3795	YCII-related domain
AMETH_RS30860	COG4941	Belongs to the sigma-70 factor family
AMETH_RS30870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AMETH_RS30885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AMETH_RS30890	COG2267	carboxylic ester hydrolase activity
AMETH_RS30900	COG0583	DNA-binding transcription factor activity
AMETH_RS30905	COG2814	Major facilitator Superfamily
AMETH_RS30910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AMETH_RS30935	COG0583	DNA-binding transcription factor activity
AMETH_RS30940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AMETH_RS30950	COG1250	3-hydroxyacyl-CoA dehydrogenase
AMETH_RS30955	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS30960	COG5479	isomerase activity
AMETH_RS30960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AMETH_RS30970	COG1064	alcohol dehydrogenase
AMETH_RS30980	COG1321	iron dependent repressor
AMETH_RS31010	COG1024	Enoyl-CoA hydratase
AMETH_RS31015	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS31030	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS31040	COG2091	lysine biosynthetic process via aminoadipic acid
AMETH_RS31045	COG1169	isochorismate synthase
AMETH_RS31055	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS31080	COG4152	abc transporter atp-binding protein
AMETH_RS31090	COG0415	Belongs to the DNA photolyase family
AMETH_RS31120	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS31125	COG1228	amidohydrolase
AMETH_RS31130	COG2017	converts alpha-aldose to the beta-anomer
AMETH_RS31135	COG1309	transcriptional regulator
AMETH_RS31180	COG0259	pyridoxamine-phosphate oxidase activity
AMETH_RS31185	COG0829	nickel cation binding
AMETH_RS31190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AMETH_RS31200	COG0832	Belongs to the urease beta subunit family
AMETH_RS31205	COG0831	urea catabolic process
AMETH_RS31220	COG0251	oxidation-reduction process
AMETH_RS31225	COG3226	Transcriptional regulator
AMETH_RS31240	COG5650	phosphatidylinositol metabolic process
AMETH_RS31260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_RS31270	COG5398	heme oxygenase
AMETH_RS31280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AMETH_RS31325	COG0789	Transcriptional regulator
AMETH_RS31540	COG1674	ftsk spoiiie
AMETH_RS31600	COG0789	Transcriptional regulator
AMETH_RS31805	COG1674	ftsk spoiiie
AMETH_RS31840	COG2814	Major facilitator Superfamily
AMETH_RS31860	COG2252	PERMEase
AMETH_RS31885	COG2814	Major facilitator Superfamily
AMETH_RS31895	COG1278	Cold shock
AMETH_RS31915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AMETH_RS31920	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS31925	COG0384	phenazine biosynthesis protein PhzF
AMETH_RS31930	COG3304	Inner membrane component domain
AMETH_RS31970	COG1846	Transcriptional regulator
AMETH_RS31985	COG1388	LysM domain
AMETH_RS32005	COG2169	Transcriptional regulator
AMETH_RS32030	COG2018	Roadblock/LC7 domain
AMETH_RS32045	COG2018	Roadblock/LC7 domain
AMETH_RS32055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AMETH_RS32060	COG0765	amino acid transport
AMETH_RS32065	COG0765	amino acid transport
AMETH_RS32085	COG1061	Type III restriction enzyme res subunit
AMETH_RS32105	COG0693	protein deglycase activity
AMETH_RS32115	COG1063	alcohol dehydrogenase
AMETH_RS32120	COG4948	Mandelate Racemase Muconate Lactonizing
AMETH_RS32140	COG0459	protein refolding
AMETH_RS32150	COG1278	Cold shock
AMETH_RS32170	COG0688	phosphatidylethanolamine metabolic process
AMETH_RS32175	COG1183	phosphatidylcholine synthase activity
AMETH_RS32200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMETH_RS32215	COG0242	peptide deformylase activity
AMETH_RS32245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AMETH_RS32265	COG2022	thiamine diphosphate biosynthetic process
AMETH_RS32275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AMETH_RS32275	COG2022	thiamine diphosphate biosynthetic process
AMETH_RS32280	COG0352	thiamine-phosphate diphosphorylase activity
AMETH_RS32290	COG2188	Transcriptional regulator
AMETH_RS32295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AMETH_RS32300	COG2971	BadF BadG BcrA BcrD
AMETH_RS32310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AMETH_RS32325	COG3903	Transcriptional regulator
AMETH_RS32325	COG3629	intracellular signal transduction
AMETH_RS32330	COG5285	phytanoyl-CoA dioxygenase
AMETH_RS32335	COG1917	Cupin 2, conserved barrel domain protein
AMETH_RS32345	COG0456	acetyltransferase
AMETH_RS32385	COG0400	carboxylic ester hydrolase activity
AMETH_RS32390	COG0346	lactoylglutathione lyase activity
AMETH_RS32425	COG0129	dihydroxy-acid dehydratase activity
AMETH_RS32465	COG0709	Synthesizes selenophosphate from selenide and ATP
AMETH_RS32475	COG1832	CoA-binding protein
AMETH_RS32480	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS32490	COG0477	Major facilitator Superfamily
AMETH_RS32525	COG0657	acetylesterase activity
AMETH_RS32565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AMETH_RS32570	COG2847	Copper chaperone PCu(A)C
AMETH_RS32575	COG1329	Transcriptional regulator
AMETH_RS32580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AMETH_RS32585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AMETH_RS32590	COG0546	phosphoglycolate phosphatase activity
AMETH_RS32595	COG0215	cysteine-tRNA ligase activity
AMETH_RS32600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_RS32630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AMETH_RS32635	COG0698	ribose 5-phosphate isomerase
AMETH_RS32640	COG2376	Dihydroxyacetone kinase
AMETH_RS32645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMETH_RS32655	COG1349	DNA-binding transcription factor activity
AMETH_RS32660	COG2814	Major facilitator Superfamily
AMETH_RS32665	COG1070	Carbohydrate kinase
AMETH_RS32675	COG4399	Belongs to the UPF0754 family
AMETH_RS32680	COG4399	Belongs to the UPF0754 family
AMETH_RS32690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AMETH_RS32695	COG1121	(ABC) transporter
AMETH_RS32705	COG1609	Transcriptional regulator
AMETH_RS32715	COG1194	a g-specific adenine glycosylase
AMETH_RS32730	COG0596	Alpha beta hydrolase
AMETH_RS32735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMETH_RS32745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AMETH_RS32760	COG0583	DNA-binding transcription factor activity
AMETH_RS32790	COG0542	response to heat
AMETH_RS32820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AMETH_RS32825	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AMETH_RS32830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AMETH_RS32855	COG0789	Transcriptional regulator
AMETH_RS32880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AMETH_RS32910	COG0037	tRNA processing
AMETH_RS32920	COG2027	D-alanyl-D-alanine carboxypeptidase
AMETH_RS32925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AMETH_RS32930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AMETH_RS32970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AMETH_RS32975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AMETH_RS32990	COG1754	DNA topoisomerase type I activity
AMETH_RS32990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AMETH_RS33015	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AMETH_RS33020	COG1205	dead DEAH box helicase
AMETH_RS33020	COG1111	helicase
AMETH_RS33070	COG1472	Belongs to the glycosyl hydrolase 3 family
AMETH_RS33075	COG3876	Protein conserved in bacteria
AMETH_RS33080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AMETH_RS33085	COG1737	Transcriptional regulator
AMETH_RS33090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AMETH_RS33100	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AMETH_RS33105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AMETH_RS33130	COG0477	Major facilitator Superfamily
AMETH_RS33140	COG4941	Belongs to the sigma-70 factor family
AMETH_RS33160	COG3104	oligopeptide transport
AMETH_RS33165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AMETH_RS33175	COG2267	carboxylic ester hydrolase activity
AMETH_RS33265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMETH_RS33270	COG1408	metallophosphoesterase
AMETH_RS33290	COG0076	glutamate decarboxylase activity
AMETH_RS33295	COG0783	Belongs to the Dps family
AMETH_RS33300	COG1764	response to oxidative stress
AMETH_RS33310	COG0657	acetylesterase activity
AMETH_RS33340	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AMETH_RS33345	COG0667	Aldo Keto reductase
AMETH_RS33395	COG0583	DNA-binding transcription factor activity
AMETH_RS33400	COG0697	spore germination
AMETH_RS33410	COG4608	Belongs to the ABC transporter superfamily
AMETH_RS33415	COG0444	Belongs to the ABC transporter superfamily
AMETH_RS33420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AMETH_RS33425	COG0601	transmembrane transport
AMETH_RS33430	COG0747	negative chemotaxis
AMETH_RS33440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AMETH_RS33445	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AMETH_RS33450	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMETH_RS33465	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AMETH_RS33475	COG2205	protein histidine kinase activity
AMETH_RS33480	COG0745	RESPONSE REGULATOR receiver
AMETH_RS33535	COG1278	Cold shock
AMETH_RS33545	COG0477	Major facilitator Superfamily
AMETH_RS33555	COG0515	serine threonine protein kinase
AMETH_RS33560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AMETH_RS33635	COG0477	Major facilitator Superfamily
AMETH_RS33690	COG2391	methyltransferase activity
AMETH_RS33695	COG0454	-acetyltransferase
AMETH_RS33705	COG0412	Dienelactone hydrolase
AMETH_RS33710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMETH_RS33715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AMETH_RS33740	COG1609	Transcriptional regulator
AMETH_RS33745	COG2814	Major facilitator Superfamily
AMETH_RS33755	COG3250	beta-galactosidase activity
AMETH_RS33770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AMETH_RS33790	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AMETH_RS33830	COG0546	phosphoglycolate phosphatase activity
AMETH_RS33835	COG2188	Transcriptional regulator
AMETH_RS33885	COG0717	Belongs to the dCTP deaminase family
AMETH_RS33895	COG0477	Major facilitator Superfamily
AMETH_RS33900	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS33905	COG1309	transcriptional regulator
AMETH_RS33920	COG0247	lactate metabolic process
AMETH_RS33920	COG2181	nitrate reductase activity
AMETH_RS33925	COG2076	Multidrug Resistance protein
AMETH_RS33935	COG0477	Major facilitator Superfamily
AMETH_RS33955	COG0443	Heat shock 70 kDa protein
AMETH_RS33960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMETH_RS33965	COG0484	heat shock protein binding
AMETH_RS33970	COG0789	Transcriptional regulator
AMETH_RS33975	COG0412	Dienelactone hydrolase
AMETH_RS33990	COG0477	Major facilitator Superfamily
AMETH_RS34005	COG0542	response to heat
AMETH_RS34015	COG4221	oxidoreductase activity
AMETH_RS34030	COG2318	DinB family
AMETH_RS34050	COG1053	succinate dehydrogenase
AMETH_RS34055	COG2223	nitrite transmembrane transporter activity
AMETH_RS34060	COG0583	DNA-binding transcription factor activity
AMETH_RS34080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AMETH_RS34085	COG3383	formate dehydrogenase (NAD+) activity
AMETH_RS34095	COG1609	Transcriptional regulator
AMETH_RS34120	COG1072	(Pantothenic acid kinase))
AMETH_RS34125	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS34135	COG0318	PFAM AMP-dependent synthetase and ligase
AMETH_RS34140	COG0586	Pfam SNARE associated Golgi protein
AMETH_RS34145	COG2353	YceI-like domain
AMETH_RS34155	COG1846	Transcriptional regulator
AMETH_RS34160	COG0277	FAD linked oxidase domain protein
AMETH_RS34170	COG0586	Pfam SNARE associated Golgi protein
AMETH_RS34200	COG0300	oxidoreductase activity
AMETH_RS34275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AMETH_RS34280	COG0025	NhaP-type Na H and K H
AMETH_RS34285	COG0477	Major facilitator Superfamily
AMETH_RS34290	COG0584	glycerophosphoryl diester phosphodiesterase
AMETH_RS34325	COG3953	SLT domain
AMETH_RS34325	COG5280	Phage tail tape measure protein TP901
AMETH_RS34330	COG0436	Aminotransferase
AMETH_RS34365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AMETH_RS34385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AMETH_RS34400	COG1012	belongs to the aldehyde dehydrogenase family
AMETH_RS34405	COG1376	ErfK ybiS ycfS ynhG family protein
AMETH_RS34430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMETH_RS34435	COG0047	phosphoribosylformylglycinamidine synthase activity
AMETH_RS34440	COG1132	(ABC) transporter
AMETH_RS34445	COG1132	(ABC) transporter
AMETH_RS34450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AMETH_RS34520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AMETH_RS34525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AMETH_RS34540	COG2378	regulation of single-species biofilm formation
AMETH_RS34575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AMETH_RS34585	COG1984	allophanate hydrolase subunit 2
AMETH_RS34595	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AMETH_RS34625	COG0745	RESPONSE REGULATOR receiver
AMETH_RS34630	COG0454	-acetyltransferase
AMETH_RS34630	COG0456	acetyltransferase
AMETH_RS34650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AMETH_RS34660	COG2357	RelA SpoT domain protein
AMETH_RS34665	COG0704	Plays a role in the regulation of phosphate uptake
AMETH_RS34685	COG0737	Belongs to the 5'-nucleotidase family
AMETH_RS34685	COG4085	toxin activity
AMETH_RS34685	COG1525	nuclease
AMETH_RS34700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AMETH_RS34710	COG3663	DNA glycosylase
AMETH_RS34715	COG2197	response regulator
AMETH_RS34720	COG1960	acyl-CoA dehydrogenase activity
AMETH_RS34735	COG0640	Transcriptional regulator
AMETH_RS34765	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AMETH_RS34800	COG3030	protein affecting phage T7 exclusion by the F plasmid
AMETH_RS34810	COG1309	transcriptional regulator
AMETH_RS34815	COG2030	dehydratase
AMETH_RS34820	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS34825	COG0183	Belongs to the thiolase family
AMETH_RS34880	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AMETH_RS34895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AMETH_RS34905	COG4585	Histidine kinase
AMETH_RS34910	COG2197	response regulator
AMETH_RS34935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AMETH_RS34945	COG1136	(ABC) transporter
AMETH_RS34955	COG2197	response regulator
AMETH_RS34975	COG0402	S-adenosylhomocysteine deaminase activity
AMETH_RS35000	COG4221	oxidoreductase activity
AMETH_RS35020	COG2814	Major facilitator Superfamily
AMETH_RS35025	COG1846	Transcriptional regulator
AMETH_RS35035	COG0640	Transcriptional regulator
AMETH_RS35040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AMETH_RS35050	COG1695	Transcriptional regulator
AMETH_RS35060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AMETH_RS35090	COG0360	Binds together with S18 to 16S ribosomal RNA
AMETH_RS35100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AMETH_RS35105	COG0359	binds to the 23S rRNA
AMETH_RS35135	COG2267	carboxylic ester hydrolase activity
AMETH_RS35150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AMETH_RS35160	COG3384	dioxygenase
AMETH_RS35195	COG2205	protein histidine kinase activity
AMETH_RS35200	COG2197	response regulator
AMETH_RS35210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AMETH_RS35220	COG0495	leucyl-tRNA aminoacylation
AMETH_RS35235	COG1678	Uncharacterized ACR, COG1678
AMETH_RS35290	COG4585	Histidine kinase
AMETH_RS35295	COG0617	tRNA 3'-terminal CCA addition
AMETH_RS35320	COG1595	DNA-templated transcription, initiation
AMETH_RS35335	COG3118	belongs to the thioredoxin family
AMETH_RS35335	COG0492	ferredoxin-NADP+ reductase activity
AMETH_RS35340	COG0860	N-Acetylmuramoyl-L-alanine amidase
AMETH_RS35340	COG3409	Peptidoglycan-binding domain 1 protein
AMETH_RS35355	COG1181	Belongs to the D-alanine--D-alanine ligase family
AMETH_RS35365	COG1192	Involved in chromosome partitioning
AMETH_RS35370	COG0357	Ribosomal RNA small subunit methyltransferase G
AMETH_RS35385	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AMETH_RS35455	COG1028	Short-chain dehydrogenase reductase Sdr
AMETH_RS35495	COG0501	Belongs to the peptidase M48B family
AMETH_RS35500	COG4585	Histidine kinase
AMETH_RS35570	COG0596	Alpha beta hydrolase
AMETH_RS35665	COG2124	cytochrome p450
AMETH_RS35685	COG1090	epimerase
AMETH_RS35695	COG0154	amidase activity
AMETH_RS35775	COG2971	BadF BadG BcrA BcrD
AMETH_RS35790	COG0456	acetyltransferase
AMETH_RS35790	COG0454	-acetyltransferase
AMETH_RS35825	COG1017	nitric oxide dioxygenase activity
AMETH_RS35825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AMETH_RS35905	COG1486	melibiose metabolic process
AMETH_RS35945	COG2271	Major facilitator Superfamily
AMETH_RS35960	COG4608	Belongs to the ABC transporter superfamily
AMETH_RS36005	COG2030	dehydratase
AMETH_RS36020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AMETH_RS36110	COG1024	Enoyl-CoA hydratase
AMETH_RS36195	COG2197	response regulator
AMETH_RS36215	COG2197	response regulator