locus-tag	class	description
SD37_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SD37_RS00025	COG0706	membrane insertase activity
SD37_RS00035	COG0357	Ribosomal RNA small subunit methyltransferase G
SD37_RS00040	COG1192	Involved in chromosome partitioning
SD37_RS00055	COG1181	Belongs to the D-alanine--D-alanine ligase family
SD37_RS00070	COG3409	Peptidoglycan-binding domain 1 protein
SD37_RS00070	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD37_RS00075	COG0492	ferredoxin-NADP+ reductase activity
SD37_RS00075	COG3118	belongs to the thioredoxin family
SD37_RS00090	COG1595	DNA-templated transcription, initiation
SD37_RS00120	COG0617	tRNA 3'-terminal CCA addition
SD37_RS00130	COG4585	Histidine kinase
SD37_RS00140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS00210	COG0495	leucyl-tRNA aminoacylation
SD37_RS00215	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS00250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_RS00255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SD37_RS00265	COG0477	Major facilitator Superfamily
SD37_RS00280	COG2197	response regulator
SD37_RS00305	COG1940	carbohydrate kinase activity
SD37_RS00305	COG1846	Transcriptional regulator
SD37_RS00310	COG0738	Major facilitator superfamily
SD37_RS00315	COG3384	dioxygenase
SD37_RS00370	COG0359	binds to the 23S rRNA
SD37_RS00375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SD37_RS00385	COG0360	Binds together with S18 to 16S ribosomal RNA
SD37_RS00425	COG1940	carbohydrate kinase activity
SD37_RS00425	COG1846	Transcriptional regulator
SD37_RS00430	COG0673	inositol 2-dehydrogenase activity
SD37_RS00435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD37_RS00440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD37_RS00450	COG1695	Transcriptional regulator
SD37_RS00475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD37_RS00485	COG2814	Major facilitator Superfamily
SD37_RS00505	COG2226	methyltransferase
SD37_RS00510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_RS00515	COG4221	oxidoreductase activity
SD37_RS00520	COG0402	S-adenosylhomocysteine deaminase activity
SD37_RS00525	COG2197	response regulator
SD37_RS00535	COG1136	(ABC) transporter
SD37_RS00545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SD37_RS00580	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS00590	COG2197	response regulator
SD37_RS00595	COG4585	Histidine kinase
SD37_RS00615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SD37_RS00630	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SD37_RS00640	COG4133	protoheme IX ABC transporter activity
SD37_RS00695	COG0456	acetyltransferase
SD37_RS00695	COG0454	-acetyltransferase
SD37_RS00705	COG0789	Transcriptional regulator
SD37_RS00710	COG0584	glycerophosphoryl diester phosphodiesterase
SD37_RS00735	COG0183	Belongs to the thiolase family
SD37_RS00740	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS00745	COG2030	dehydratase
SD37_RS00750	COG1309	transcriptional regulator
SD37_RS00770	COG3030	protein affecting phage T7 exclusion by the F plasmid
SD37_RS00805	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD37_RS00810	COG0022	dehydrogenase e1 component
SD37_RS00820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_RS00825	COG0596	Alpha beta hydrolase
SD37_RS00835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_RS00840	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_RS00845	COG1305	Transglutaminase-like
SD37_RS00860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_RS00865	COG0765	amino acid transport
SD37_RS00870	COG1126	abc transporter atp-binding protein
SD37_RS00930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SD37_RS00955	COG1960	acyl-CoA dehydrogenase activity
SD37_RS00960	COG2197	response regulator
SD37_RS00965	COG3663	DNA glycosylase
SD37_RS00990	COG0737	Belongs to the 5'-nucleotidase family
SD37_RS01030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SD37_RS01045	COG0717	Belongs to the dCTP deaminase family
SD37_RS01055	COG1846	Transcriptional regulator
SD37_RS01060	COG2340	Cysteine-rich secretory protein family
SD37_RS01075	COG0247	lactate metabolic process
SD37_RS01075	COG2181	nitrate reductase activity
SD37_RS01080	COG2076	Multidrug Resistance protein
SD37_RS01115	COG0443	Heat shock 70 kDa protein
SD37_RS01120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SD37_RS01125	COG0484	heat shock protein binding
SD37_RS01130	COG0789	Transcriptional regulator
SD37_RS01165	COG0542	response to heat
SD37_RS01190	COG0577	efflux transmembrane transporter activity
SD37_RS01190	COG1136	(ABC) transporter
SD37_RS01210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD37_RS01215	COG0243	molybdopterin cofactor binding
SD37_RS01230	COG1609	Transcriptional regulator
SD37_RS01235	COG1609	Transcriptional regulator
SD37_RS01255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_RS01260	COG1072	(Pantothenic acid kinase))
SD37_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS01275	COG0586	Pfam SNARE associated Golgi protein
SD37_RS01280	COG0477	Major facilitator Superfamily
SD37_RS01290	COG3467	pyridoxamine 5'-phosphate
SD37_RS01300	COG0477	Major facilitator Superfamily
SD37_RS01305	COG0277	FAD linked oxidase domain protein
SD37_RS01310	COG0586	Pfam SNARE associated Golgi protein
SD37_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS01360	COG0667	Aldo Keto reductase
SD37_RS01425	COG1819	glycosyl
SD37_RS01430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS01435	COG4172	Belongs to the ABC transporter superfamily
SD37_RS01440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD37_RS01465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SD37_RS01480	COG2814	Major facilitator Superfamily
SD37_RS01490	COG0584	glycerophosphoryl diester phosphodiesterase
SD37_RS01525	COG3953	SLT domain
SD37_RS01525	COG5412	phage tail tape measure protein
SD37_RS01540	COG0436	Aminotransferase
SD37_RS01580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SD37_RS01590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_RS01600	COG0765	amino acid transport
SD37_RS01605	COG1126	abc transporter atp-binding protein
SD37_RS01620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SD37_RS01635	COG2311	Membrane
SD37_RS01640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SD37_RS01670	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SD37_RS01675	COG0047	phosphoribosylformylglycinamidine synthase activity
SD37_RS01680	COG1132	(ABC) transporter
SD37_RS01685	COG1132	(ABC) transporter
SD37_RS01755	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SD37_RS01805	COG0354	folic acid binding
SD37_RS01820	COG1984	allophanate hydrolase subunit 2
SD37_RS01830	COG4044	May play a role in the intracellular transport of hydrophobic ligands
SD37_RS01860	COG0745	RESPONSE REGULATOR receiver
SD37_RS01885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SD37_RS01890	COG0704	Plays a role in the regulation of phosphate uptake
SD37_RS01905	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SD37_RS01910	COG0596	Alpha beta hydrolase
SD37_RS01960	COG3973	AAA domain
SD37_RS01990	COG1473	amidohydrolase
SD37_RS02005	COG3237	CsbD-like
SD37_RS02020	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
SD37_RS02080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SD37_RS02080	COG5479	isomerase activity
SD37_RS02085	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SD37_RS02085	COG5479	isomerase activity
SD37_RS02090	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_RS02120	COG2197	response regulator
SD37_RS02140	COG0745	RESPONSE REGULATOR receiver
SD37_RS02145	COG2205	protein histidine kinase activity
SD37_RS02150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_RS02170	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD37_RS02175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SD37_RS02180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SD37_RS02185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SD37_RS02190	COG1215	transferase activity, transferring glycosyl groups
SD37_RS02205	COG0463	Glycosyl transferase, family 2
SD37_RS02220	COG0747	negative chemotaxis
SD37_RS02225	COG0601	transmembrane transport
SD37_RS02230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD37_RS02240	COG4608	Belongs to the ABC transporter superfamily
SD37_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS02265	COG0697	spore germination
SD37_RS02270	COG0583	DNA-binding transcription factor activity
SD37_RS02305	COG0477	Major facilitator Superfamily
SD37_RS02330	COG0501	Belongs to the peptidase M48B family
SD37_RS02335	COG1690	Belongs to the RtcB family
SD37_RS02345	COG3293	Transposase
SD37_RS02380	COG1764	response to oxidative stress
SD37_RS02385	COG0783	Belongs to the Dps family
SD37_RS02390	COG0076	glutamate decarboxylase activity
SD37_RS02420	COG1408	metallophosphoesterase
SD37_RS02425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD37_RS02450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SD37_RS02480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SD37_RS02510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD37_RS02530	COG0596	Alpha beta hydrolase
SD37_RS02540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SD37_RS02545	COG3104	oligopeptide transport
SD37_RS02585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_RS02595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SD37_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS02635	COG0640	Transcriptional regulator
SD37_RS02640	COG2814	Major facilitator Superfamily
SD37_RS02645	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SD37_RS02650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SD37_RS02655	COG1737	Transcriptional regulator
SD37_RS02660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_RS02665	COG3876	Protein conserved in bacteria
SD37_RS02670	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_RS02720	COG1111	helicase
SD37_RS02720	COG1205	dead DEAH box helicase
SD37_RS02725	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SD37_RS02750	COG1754	DNA topoisomerase type I activity
SD37_RS02750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SD37_RS02775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SD37_RS02780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SD37_RS02805	COG0657	acetylesterase activity
SD37_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS02830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SD37_RS02835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SD37_RS02855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SD37_RS02865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SD37_RS02870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SD37_RS02875	COG2027	D-alanyl-D-alanine carboxypeptidase
SD37_RS02885	COG0037	tRNA processing
SD37_RS02915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SD37_RS02920	COG0302	gtp cyclohydrolase
SD37_RS02925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SD37_RS02940	COG0789	Transcriptional regulator
SD37_RS02965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SD37_RS02970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SD37_RS02975	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SD37_RS03015	COG0443	Heat shock 70 kDa protein
SD37_RS03020	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SD37_RS03050	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SD37_RS03065	COG0596	Alpha beta hydrolase
SD37_RS03070	COG3118	belongs to the thioredoxin family
SD37_RS03105	COG2814	Major facilitator Superfamily
SD37_RS03115	COG1194	a g-specific adenine glycosylase
SD37_RS03125	COG1609	Transcriptional regulator
SD37_RS03130	COG0803	Belongs to the bacterial solute-binding protein 9 family
SD37_RS03135	COG1120	ATPase activity
SD37_RS03155	COG4399	Belongs to the UPF0754 family
SD37_RS03170	COG0235	Class ii aldolase
SD37_RS03195	COG1309	transcriptional regulator
SD37_RS03230	COG0215	cysteine-tRNA ligase activity
SD37_RS03250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SD37_RS03255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SD37_RS03260	COG1329	Transcriptional regulator
SD37_RS03265	COG2847	Copper chaperone PCu(A)C
SD37_RS03270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SD37_RS03300	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SD37_RS03375	COG0640	Transcriptional regulator
SD37_RS03395	COG1595	DNA-templated transcription, initiation
SD37_RS03400	COG0583	DNA-binding transcription factor activity
SD37_RS03410	COG3795	YCII-related domain
SD37_RS03415	COG4941	Belongs to the sigma-70 factor family
SD37_RS03430	COG1620	l-lactate permease
SD37_RS03440	COG1832	CoA-binding protein
SD37_RS03450	COG3971	2-oxopent-4-enoate hydratase activity
SD37_RS03485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_RS03495	COG0346	lactoylglutathione lyase activity
SD37_RS03500	COG0400	carboxylic ester hydrolase activity
SD37_RS03510	COG5416	Lipopolysaccharide assembly protein A domain
SD37_RS03540	COG1733	regulation of RNA biosynthetic process
SD37_RS03550	COG1752	Esterase of the alpha-beta hydrolase superfamily
SD37_RS03555	COG0456	acetyltransferase
SD37_RS03565	COG1917	Cupin 2, conserved barrel domain protein
SD37_RS03570	COG5285	phytanoyl-CoA dioxygenase
SD37_RS03575	COG3903	Transcriptional regulator
SD37_RS03575	COG3629	intracellular signal transduction
SD37_RS03605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SD37_RS03615	COG2971	BadF BadG BcrA BcrD
SD37_RS03620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD37_RS03625	COG2188	Transcriptional regulator
SD37_RS03630	COG0477	Major facilitator Superfamily
SD37_RS03645	COG0352	thiamine-phosphate diphosphorylase activity
SD37_RS03650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD37_RS03650	COG2022	thiamine diphosphate biosynthetic process
SD37_RS03660	COG2022	thiamine diphosphate biosynthetic process
SD37_RS03690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SD37_RS03700	COG0242	peptide deformylase activity
SD37_RS03715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SD37_RS03725	COG0688	phosphatidylethanolamine metabolic process
SD37_RS03730	COG2261	transglycosylase associated protein
SD37_RS03760	COG1278	Cold shock
SD37_RS03770	COG0459	protein refolding
SD37_RS03790	COG4942	peptidase
SD37_RS03790	COG1388	LysM domain
SD37_RS03795	COG4948	Mandelate Racemase Muconate Lactonizing
SD37_RS03800	COG3903	Transcriptional regulator
SD37_RS03800	COG3629	intracellular signal transduction
SD37_RS03815	COG1061	Type III restriction enzyme res subunit
SD37_RS03835	COG3142	Participates in the control of copper homeostasis
SD37_RS03845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SD37_RS03845	COG1116	anion transmembrane transporter activity
SD37_RS03850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD37_RS03855	COG1174	glycine betaine transport
SD37_RS03875	COG2018	Roadblock/LC7 domain
SD37_RS03890	COG2018	Roadblock/LC7 domain
SD37_RS03925	COG0521	Mo-molybdopterin cofactor biosynthetic process
SD37_RS03935	COG1388	LysM domain
SD37_RS03950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SD37_RS03955	COG1846	Transcriptional regulator
SD37_RS03990	COG3304	Inner membrane component domain
SD37_RS03995	COG0384	phenazine biosynthesis protein PhzF
SD37_RS04005	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS04015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SD37_RS04020	COG1309	transcriptional regulator
SD37_RS04035	COG1278	Cold shock
SD37_RS04045	COG2814	Major facilitator Superfamily
SD37_RS04070	COG2252	PERMEase
SD37_RS04080	COG2814	Major facilitator Superfamily
SD37_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS04130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD37_RS04180	COG2205	protein histidine kinase activity
SD37_RS04185	COG0745	RESPONSE REGULATOR receiver
SD37_RS04190	COG2133	pyrroloquinoline quinone binding
SD37_RS04190	COG5183	chlorophyll binding
SD37_RS04205	COG1136	(ABC) transporter
SD37_RS04205	COG0577	efflux transmembrane transporter activity
SD37_RS04210	COG0577	efflux transmembrane transporter activity
SD37_RS04210	COG1136	(ABC) transporter
SD37_RS04215	COG5650	phosphatidylinositol metabolic process
SD37_RS04240	COG2197	response regulator
SD37_RS04245	COG4585	Histidine kinase
SD37_RS04255	COG1131	(ABC) transporter
SD37_RS04295	COG0831	urea catabolic process
SD37_RS04300	COG0832	Belongs to the urease beta subunit family
SD37_RS04305	COG0804	urea catabolic process
SD37_RS04315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SD37_RS04320	COG0829	nickel cation binding
SD37_RS04350	COG0642	Histidine kinase
SD37_RS04355	COG1116	anion transmembrane transporter activity
SD37_RS04360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD37_RS04380	COG0259	pyridoxamine-phosphate oxidase activity
SD37_RS04410	COG1309	transcriptional regulator
SD37_RS04415	COG1192	Involved in chromosome partitioning
SD37_RS04425	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS04430	COG2017	converts alpha-aldose to the beta-anomer
SD37_RS04440	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SD37_RS04450	COG1960	acyl-CoA dehydrogenase activity
SD37_RS04470	COG0415	Belongs to the DNA photolyase family
SD37_RS04480	COG4152	abc transporter atp-binding protein
SD37_RS04515	COG0277	FAD linked oxidase domain protein
SD37_RS04545	COG0789	Transcriptional regulator
SD37_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS04550	COG0604	alcohol dehydrogenase
SD37_RS04550	COG3321	synthase
SD37_RS04585	COG1169	isochorismate synthase
SD37_RS04595	COG1301	dicarboxylic acid transport
SD37_RS04600	COG1960	acyl-CoA dehydrogenase activity
SD37_RS04615	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS04620	COG1024	Enoyl-CoA hydratase
SD37_RS04625	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SD37_RS04635	COG1321	iron dependent repressor
SD37_RS04655	COG1984	allophanate hydrolase subunit 2
SD37_RS04660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SD37_RS04665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SD37_RS04670	COG4336	lyase activity
SD37_RS04675	COG2814	Major facilitator Superfamily
SD37_RS04690	COG1940	carbohydrate kinase activity
SD37_RS04730	COG2755	lipolytic protein G-D-S-L family
SD37_RS04730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SD37_RS04740	COG0583	DNA-binding transcription factor activity
SD37_RS04745	COG2264	protein methyltransferase activity
SD37_RS04750	COG0702	epimerase
SD37_RS04765	COG4941	Belongs to the sigma-70 factor family
SD37_RS04780	COG1131	(ABC) transporter
SD37_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS04800	COG4221	oxidoreductase activity
SD37_RS04825	COG3629	intracellular signal transduction
SD37_RS04825	COG3903	Transcriptional regulator
SD37_RS04855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SD37_RS04910	COG2197	response regulator
SD37_RS04915	COG2860	membrane
SD37_RS04925	COG2205	protein histidine kinase activity
SD37_RS04935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SD37_RS04945	COG1349	DNA-binding transcription factor activity
SD37_RS04955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD37_RS04985	COG2372	response to copper ion
SD37_RS04985	COG1276	copper resistance
SD37_RS05010	COG3794	PFAM blue (type 1) copper domain protein
SD37_RS05020	COG0745	RESPONSE REGULATOR receiver
SD37_RS05025	COG5002	protein histidine kinase activity
SD37_RS05035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_RS05040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SD37_RS05045	COG0315	cyclic pyranopterin monophosphate synthase activity
SD37_RS05045	COG0521	Mo-molybdopterin cofactor biosynthetic process
SD37_RS05105	COG0475	glutathione-regulated potassium exporter activity
SD37_RS05115	COG2223	nitrite transmembrane transporter activity
SD37_RS05135	COG2124	cytochrome p450
SD37_RS05140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD37_RS05150	COG4221	oxidoreductase activity
SD37_RS05185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_RS05210	COG0596	Alpha beta hydrolase
SD37_RS05220	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SD37_RS05245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_RS05250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SD37_RS05275	COG2814	Major facilitator Superfamily
SD37_RS05285	COG0367	asparagine synthase
SD37_RS05300	COG0697	spore germination
SD37_RS05320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SD37_RS05350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD37_RS05360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SD37_RS05365	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SD37_RS05370	COG2226	methyltransferase
SD37_RS05375	COG2409	Drug exporters of the RND superfamily
SD37_RS05425	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS05440	COG2258	MOSC domain
SD37_RS05525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD37_RS05530	COG0084	hydrolase, TatD family'
SD37_RS05545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SD37_RS05550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SD37_RS05555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SD37_RS05560	COG0488	(ABC) transporter
SD37_RS05565	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS05580	COG0193	aminoacyl-tRNA hydrolase activity
SD37_RS05610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SD37_RS05655	COG2133	pyrroloquinoline quinone binding
SD37_RS05660	COG2197	response regulator
SD37_RS05665	COG4585	Histidine kinase
SD37_RS05670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SD37_RS05675	COG0586	Pfam SNARE associated Golgi protein
SD37_RS05685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS05710	COG1733	regulation of RNA biosynthetic process
SD37_RS05715	COG1595	DNA-templated transcription, initiation
SD37_RS05725	COG1131	(ABC) transporter
SD37_RS05755	COG2837	iron assimilation
SD37_RS05765	COG0672	)-iron permease
SD37_RS05775	COG0492	ferredoxin-NADP+ reductase activity
SD37_RS05795	COG0148	phosphopyruvate hydratase activity
SD37_RS05820	COG4166	transmembrane transport
SD37_RS05825	COG0601	transmembrane transport
SD37_RS05830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD37_RS05835	COG0444	Belongs to the ABC transporter superfamily
SD37_RS05840	COG4608	Belongs to the ABC transporter superfamily
SD37_RS05845	COG1404	Belongs to the peptidase S8 family
SD37_RS05860	COG1515	deoxyribonuclease V activity
SD37_RS05870	COG1252	NADH dehydrogenase
SD37_RS05890	COG0745	RESPONSE REGULATOR receiver
SD37_RS05905	COG2197	response regulator
SD37_RS05910	COG4585	Histidine kinase
SD37_RS05935	COG0406	alpha-ribazole phosphatase activity
SD37_RS05940	COG2124	cytochrome p450
SD37_RS05955	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_RS05965	COG1902	pentaerythritol trinitrate reductase activity
SD37_RS06010	COG2391	methyltransferase activity
SD37_RS06015	COG0477	Major facilitator Superfamily
SD37_RS06020	COG0183	Belongs to the thiolase family
SD37_RS06060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_RS06095	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SD37_RS06105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_RS06110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SD37_RS06120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD37_RS06130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SD37_RS06140	COG1331	Highly conserved protein containing a thioredoxin domain
SD37_RS06165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SD37_RS06195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SD37_RS06250	COG1793	dna ligase
SD37_RS06275	COG0114	fumarate hydratase activity
SD37_RS06280	COG0492	ferredoxin-NADP+ reductase activity
SD37_RS06295	COG1722	exodeoxyribonuclease VII activity
SD37_RS06305	COG1570	exodeoxyribonuclease VII activity
SD37_RS06315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SD37_RS06330	COG0420	3'-5' exonuclease activity
SD37_RS06335	COG0419	ATPase involved in DNA repair
SD37_RS06350	COG0012	GTP binding
SD37_RS06360	COG2234	aminopeptidase activity
SD37_RS06380	COG3654	unkown
SD37_RS06390	COG2154	pterin-4-alpha-carbinolamine dehydratase
SD37_RS06400	COG4149	molybdate abc transporter
SD37_RS06405	COG3842	ATPase activity
SD37_RS06415	COG1131	(ABC) transporter
SD37_RS06440	COG0180	Tryptophanyl-tRNA synthetase
SD37_RS06450	COG1217	gtp-binding protein TYPA
SD37_RS06455	COG0477	Major facilitator Superfamily
SD37_RS06460	COG0747	negative chemotaxis
SD37_RS06470	COG0601	transmembrane transport
SD37_RS06485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD37_RS06500	COG1994	Peptidase M50
SD37_RS06525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD37_RS06530	COG2835	tetraacyldisaccharide 4'-kinase activity
SD37_RS06540	COG1482	cell wall glycoprotein biosynthetic process
SD37_RS06550	COG3629	intracellular signal transduction
SD37_RS06550	COG3903	Transcriptional regulator
SD37_RS06560	COG0531	amino acid
SD37_RS06575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SD37_RS06600	COG4638	Rieske (2fe-2S)
SD37_RS06605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD37_RS06620	COG2146	nitrite reductase [NAD(P)H] activity
SD37_RS06630	COG0745	RESPONSE REGULATOR receiver
SD37_RS06635	COG5002	protein histidine kinase activity
SD37_RS06635	COG5000	phosphorelay sensor kinase activity
SD37_RS06650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SD37_RS06655	COG0653	protein targeting
SD37_RS06665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD37_RS06670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD37_RS06705	COG1162	GTPase activity
SD37_RS06710	COG2135	peptidase activity
SD37_RS06725	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SD37_RS06750	COG1597	lipid kinase activity
SD37_RS06765	COG0406	alpha-ribazole phosphatase activity
SD37_RS06785	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SD37_RS06790	COG0281	malic enzyme
SD37_RS06800	COG1125	glycine betaine transport
SD37_RS06800	COG0517	IMP dehydrogenase activity
SD37_RS06810	COG1174	glycine betaine transport
SD37_RS06820	COG3153	acetyltransferase
SD37_RS06825	COG1404	Belongs to the peptidase S8 family
SD37_RS06840	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD37_RS06840	COG0567	Dehydrogenase, E1 component
SD37_RS06855	COG1132	(ABC) transporter
SD37_RS06870	COG0686	Belongs to the AlaDH PNT family
SD37_RS06890	COG2508	Transcriptional regulator
SD37_RS06890	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD37_RS06900	COG1695	Transcriptional regulator
SD37_RS06905	COG0346	lactoylglutathione lyase activity
SD37_RS06915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_RS06930	COG2755	lipolytic protein G-D-S-L family
SD37_RS06935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_RS06945	COG1960	acyl-CoA dehydrogenase activity
SD37_RS06960	COG4221	oxidoreductase activity
SD37_RS06975	COG1960	acyl-CoA dehydrogenase activity
SD37_RS06995	COG0183	Belongs to the thiolase family
SD37_RS07000	COG1024	Enoyl-CoA hydratase
SD37_RS07000	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_RS07015	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS07025	COG0477	Major facilitator Superfamily
SD37_RS07030	COG0028	Belongs to the TPP enzyme family
SD37_RS07045	COG3629	intracellular signal transduction
SD37_RS07045	COG3903	Transcriptional regulator
SD37_RS07060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SD37_RS07070	COG0473	3-isopropylmalate dehydrogenase activity
SD37_RS07100	COG0154	amidase activity
SD37_RS07115	COG0667	Aldo Keto reductase
SD37_RS07135	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SD37_RS07145	COG2133	pyrroloquinoline quinone binding
SD37_RS07155	COG0435	Glutathione S-transferase
SD37_RS07195	COG3345	alpha-galactosidase
SD37_RS07200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD37_RS07250	COG2910	NAD(P)H-binding
SD37_RS07260	COG3795	YCII-related domain
SD37_RS07275	COG4941	Belongs to the sigma-70 factor family
SD37_RS07295	COG1169	isochorismate synthase
SD37_RS07320	COG4171	peptide transport system, permease
SD37_RS07330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS07330	COG3433	isochorismatase activity
SD37_RS07330	COG2226	methyltransferase
SD37_RS07350	COG2226	methyltransferase
SD37_RS07355	COG1021	2,3-dihydroxybenzoate-AMP ligase
SD37_RS07365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS07375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_RS07380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_RS07395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SD37_RS07400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SD37_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS07455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_RS07470	COG0596	Alpha beta hydrolase
SD37_RS07490	COG0018	arginyl-trna synthetase
SD37_RS07495	COG0019	diaminopimelate decarboxylase activity
SD37_RS07500	COG0460	homoserine dehydrogenase
SD37_RS07505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SD37_RS07510	COG0083	homoserine kinase activity
SD37_RS07525	COG0254	rRNA binding
SD37_RS07530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SD37_RS07555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_RS07565	COG0596	Alpha beta hydrolase
SD37_RS07570	COG0789	Transcriptional regulator
SD37_RS07575	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SD37_RS07580	COG2890	protein-(glutamine-N5) methyltransferase activity
SD37_RS07595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SD37_RS07605	COG0356	it plays a direct role in the translocation of protons across the membrane
SD37_RS07610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SD37_RS07615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SD37_RS07620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SD37_RS07625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SD37_RS07630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SD37_RS07635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SD37_RS07640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SD37_RS07650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SD37_RS07665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SD37_RS07680	COG1280	lysine exporter protein (LysE YggA)
SD37_RS07685	COG1280	lysine exporter protein (LysE YggA)
SD37_RS07695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SD37_RS07695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SD37_RS07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_RS07705	COG0765	amino acid transport
SD37_RS07710	COG0765	amino acid transport
SD37_RS07715	COG1126	abc transporter atp-binding protein
SD37_RS07720	COG1335	isochorismatase
SD37_RS07725	COG4977	sequence-specific DNA binding
SD37_RS07740	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SD37_RS07745	COG1752	Esterase of the alpha-beta hydrolase superfamily
SD37_RS07770	COG2376	Dihydroxyacetone kinase
SD37_RS07775	COG1461	Dihydroxyacetone kinase
SD37_RS07805	COG1522	sequence-specific DNA binding
SD37_RS07810	COG0626	cystathionine gamma-synthase activity
SD37_RS07835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SD37_RS07860	COG1819	glycosyl
SD37_RS07870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SD37_RS07875	COG3830	Belongs to the UPF0237 family
SD37_RS07875	COG0560	Phosphoserine phosphatase
SD37_RS07900	COG1268	BioY protein
SD37_RS07910	COG0800	Aldolase
SD37_RS07915	COG1335	isochorismatase
SD37_RS07920	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SD37_RS07935	COG3191	aminopeptidase activity
SD37_RS07955	COG1794	racemase activity, acting on amino acids and derivatives
SD37_RS07970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SD37_RS07980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SD37_RS07985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SD37_RS08030	COG4585	Histidine kinase
SD37_RS08035	COG2197	response regulator
SD37_RS08070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SD37_RS08140	COG1316	TRANSCRIPTIONal
SD37_RS08150	COG3706	GGDEF domain
SD37_RS08160	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS08180	COG3844	kynureninase activity
SD37_RS08195	COG2018	Roadblock/LC7 domain
SD37_RS08210	COG2259	Doxx family
SD37_RS08215	COG2259	Doxx family
SD37_RS08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD37_RS08255	COG1408	metallophosphoesterase
SD37_RS08265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SD37_RS08270	COG1309	transcriptional regulator
SD37_RS08305	COG3469	chitinase activity
SD37_RS08315	COG0698	ribose 5-phosphate isomerase
SD37_RS08340	COG2267	carboxylic ester hydrolase activity
SD37_RS08345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SD37_RS08355	COG2814	Major facilitator Superfamily
SD37_RS08385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD37_RS08395	COG0673	inositol 2-dehydrogenase activity
SD37_RS08405	COG1309	transcriptional regulator
SD37_RS08410	COG1024	Enoyl-CoA hydratase
SD37_RS08425	COG2318	DinB family
SD37_RS08460	COG2197	response regulator
SD37_RS08465	COG1404	Belongs to the peptidase S8 family
SD37_RS08485	COG0531	amino acid
SD37_RS08500	COG1376	ErfK ybiS ycfS ynhG family protein
SD37_RS08510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SD37_RS08515	COG0433	COG0433 Predicted ATPase
SD37_RS08525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD37_RS08535	COG2226	methyltransferase
SD37_RS08540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SD37_RS08550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SD37_RS08555	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_RS08585	COG0346	lactoylglutathione lyase activity
SD37_RS08590	COG0183	Belongs to the thiolase family
SD37_RS08615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS08620	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_RS08630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_RS08640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_RS08650	COG3279	Response regulator of the LytR AlgR family
SD37_RS08655	COG3275	phosphorelay sensor kinase activity
SD37_RS08685	COG1609	Transcriptional regulator
SD37_RS08695	COG3537	Alpha-1,2-mannosidase
SD37_RS08705	COG1846	Transcriptional regulator
SD37_RS08730	COG0058	SHG alpha-glucan phosphorylase activity
SD37_RS08750	COG1119	ATPase activity
SD37_RS08755	COG1024	Enoyl-CoA hydratase
SD37_RS08760	COG2226	methyltransferase
SD37_RS08840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SD37_RS08875	COG0791	NLP P60 protein
SD37_RS08875	COG3883	PFAM NLP P60 protein
SD37_RS08880	COG1957	nucleoside hydrolase
SD37_RS08885	COG0110	maltose O-acetyltransferase activity
SD37_RS08900	COG0702	epimerase
SD37_RS08915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SD37_RS08925	COG3250	beta-galactosidase activity
SD37_RS08940	COG0386	Belongs to the glutathione peroxidase family
SD37_RS08950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_RS08960	COG1307	EDD domain protein, DegV family
SD37_RS08970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SD37_RS08995	COG0477	Major facilitator Superfamily
SD37_RS09005	COG0482	sulfurtransferase activity
SD37_RS09010	COG0456	acetyltransferase
SD37_RS09015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_RS09035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SD37_RS09055	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SD37_RS09060	COG0154	amidase activity
SD37_RS09100	COG0129	dihydroxy-acid dehydratase activity
SD37_RS09115	COG0440	acetolactate synthase activity
SD37_RS09120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SD37_RS09170	COG1404	Belongs to the peptidase S8 family
SD37_RS09175	COG0473	3-isopropylmalate dehydrogenase activity
SD37_RS09180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SD37_RS09185	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD37_RS09270	COG0667	Aldo Keto reductase
SD37_RS09275	COG2050	protein possibly involved in aromatic compounds catabolism
SD37_RS09295	COG2175	clavaminate synthase activity
SD37_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS09330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD37_RS09345	COG2867	negative regulation of translational initiation
SD37_RS09390	COG0745	RESPONSE REGULATOR receiver
SD37_RS09395	COG2197	response regulator
SD37_RS09410	COG1228	amidohydrolase
SD37_RS09415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_RS09435	COG1522	sequence-specific DNA binding
SD37_RS09440	COG1024	Enoyl-CoA hydratase
SD37_RS09440	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_RS09445	COG0183	Belongs to the thiolase family
SD37_RS09450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SD37_RS09470	COG1960	acyl-CoA dehydrogenase activity
SD37_RS09480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SD37_RS09485	COG1024	Enoyl-CoA hydratase
SD37_RS09505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_RS09510	COG0747	negative chemotaxis
SD37_RS09520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD37_RS09530	COG4608	Belongs to the ABC transporter superfamily
SD37_RS09535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_RS09545	COG2197	response regulator
SD37_RS09560	COG2409	Drug exporters of the RND superfamily
SD37_RS09565	COG2205	protein histidine kinase activity
SD37_RS09570	COG0745	RESPONSE REGULATOR receiver
SD37_RS09575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SD37_RS09585	COG1301	dicarboxylic acid transport
SD37_RS09590	COG0439	Biotin carboxylase
SD37_RS09600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD37_RS09615	COG0464	growth
SD37_RS09655	COG1404	Belongs to the peptidase S8 family
SD37_RS09660	COG1674	ftsk spoiiie
SD37_RS09670	COG2124	cytochrome p450
SD37_RS09675	COG2197	response regulator
SD37_RS09680	COG2124	cytochrome p450
SD37_RS09685	COG0667	Aldo Keto reductase
SD37_RS09700	COG2986	histidine ammonia-lyase
SD37_RS09780	COG2318	DinB family
SD37_RS09790	COG0667	Aldo Keto reductase
SD37_RS09795	COG0300	oxidoreductase activity
SD37_RS09815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_RS09830	COG1280	lysine exporter protein (LysE YggA)
SD37_RS09870	COG3483	tryptophan 2,3-dioxygenase activity
SD37_RS09875	COG0076	glutamate decarboxylase activity
SD37_RS09890	COG0697	spore germination
SD37_RS09905	COG2130	NADP-dependent
SD37_RS09910	COG0583	DNA-binding transcription factor activity
SD37_RS09915	COG4733	cellulase activity
SD37_RS09935	COG0583	DNA-binding transcription factor activity
SD37_RS09945	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS09950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SD37_RS09975	COG3903	Transcriptional regulator
SD37_RS09975	COG3629	intracellular signal transduction
SD37_RS09995	COG1063	alcohol dehydrogenase
SD37_RS10010	COG2197	response regulator
SD37_RS10020	COG1175	transmembrane transport
SD37_RS10035	COG3629	intracellular signal transduction
SD37_RS10035	COG3903	Transcriptional regulator
SD37_RS10040	COG3629	intracellular signal transduction
SD37_RS10040	COG3903	Transcriptional regulator
SD37_RS10060	COG2197	response regulator
SD37_RS10075	COG1113	amino acid transport
SD37_RS10115	COG1169	isochorismate synthase
SD37_RS10140	COG4171	peptide transport system, permease
SD37_RS10145	COG4172	Belongs to the ABC transporter superfamily
SD37_RS10150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS10150	COG3433	isochorismatase activity
SD37_RS10150	COG2226	methyltransferase
SD37_RS10160	COG1132	(ABC) transporter
SD37_RS10175	COG0367	asparagine synthase
SD37_RS10180	COG2124	cytochrome p450
SD37_RS10185	COG1021	2,3-dihydroxybenzoate-AMP ligase
SD37_RS10190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS10190	COG3433	isochorismatase activity
SD37_RS10190	COG2226	methyltransferase
SD37_RS10230	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS10235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SD37_RS10245	COG2986	histidine ammonia-lyase
SD37_RS10260	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS10265	COG2197	response regulator
SD37_RS10270	COG0604	alcohol dehydrogenase
SD37_RS10270	COG3321	synthase
SD37_RS10270	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS10275	COG3321	synthase
SD37_RS10275	COG0604	alcohol dehydrogenase
SD37_RS10280	COG2197	response regulator
SD37_RS10295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SD37_RS10310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SD37_RS10315	COG1278	Cold shock
SD37_RS10355	COG3883	PFAM NLP P60 protein
SD37_RS10355	COG0791	NLP P60 protein
SD37_RS10390	COG2132	Multicopper oxidase
SD37_RS10400	COG3246	L-lysine catabolic process to acetate
SD37_RS10415	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD37_RS10420	COG0402	S-adenosylhomocysteine deaminase activity
SD37_RS10425	COG2072	flavoprotein involved in K transport
SD37_RS10430	COG3321	synthase
SD37_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS10430	COG0604	alcohol dehydrogenase
SD37_RS10440	COG2124	cytochrome p450
SD37_RS10470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS10475	COG1960	acyl-CoA dehydrogenase activity
SD37_RS10490	COG0446	pyridine nucleotide-disulphide oxidoreductase
SD37_RS10490	COG1902	pentaerythritol trinitrate reductase activity
SD37_RS10495	COG0504	CTP synthase activity
SD37_RS10505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SD37_RS10510	COG3956	TIGRFAM MazG family protein
SD37_RS10540	COG3629	intracellular signal transduction
SD37_RS10540	COG3903	Transcriptional regulator
SD37_RS10585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS10585	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS10585	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS10585	COG0300	oxidoreductase activity
SD37_RS10585	COG3321	synthase
SD37_RS10595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SD37_RS10620	COG2030	dehydratase
SD37_RS10625	COG0477	Major facilitator Superfamily
SD37_RS10635	COG0477	Major facilitator Superfamily
SD37_RS10650	COG0183	Belongs to the thiolase family
SD37_RS10660	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_RS10740	COG1309	transcriptional regulator
SD37_RS10745	COG3473	Maleate cis-trans isomerase
SD37_RS10760	COG0145	ligase activity
SD37_RS10790	COG2197	response regulator
SD37_RS10815	COG3321	synthase
SD37_RS10815	COG0604	alcohol dehydrogenase
SD37_RS10835	COG0601	transmembrane transport
SD37_RS10840	COG0444	Belongs to the ABC transporter superfamily
SD37_RS10865	COG1819	glycosyl
SD37_RS10875	COG1132	(ABC) transporter
SD37_RS10900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD37_RS10905	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_RS10935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SD37_RS10950	COG0546	phosphoglycolate phosphatase activity
SD37_RS10980	COG0604	alcohol dehydrogenase
SD37_RS10980	COG3321	synthase
SD37_RS10985	COG0604	alcohol dehydrogenase
SD37_RS10985	COG3321	synthase
SD37_RS10990	COG0475	glutathione-regulated potassium exporter activity
SD37_RS11020	COG0367	asparagine synthase
SD37_RS11030	COG3239	Fatty acid desaturase
SD37_RS11055	COG1013	pyruvate-flavodoxin oxidoreductase activity
SD37_RS11065	COG2076	Multidrug Resistance protein
SD37_RS11140	COG3629	intracellular signal transduction
SD37_RS11140	COG3903	Transcriptional regulator
SD37_RS11145	COG0464	growth
SD37_RS11150	COG1404	Belongs to the peptidase S8 family
SD37_RS11155	COG1674	ftsk spoiiie
SD37_RS11165	COG3266	domain, Protein
SD37_RS11225	COG3903	Transcriptional regulator
SD37_RS11225	COG3629	intracellular signal transduction
SD37_RS11280	COG2508	Transcriptional regulator
SD37_RS11285	COG2072	flavoprotein involved in K transport
SD37_RS11315	COG2223	nitrite transmembrane transporter activity
SD37_RS11320	COG2207	Transcriptional regulator
SD37_RS11330	COG3903	Transcriptional regulator
SD37_RS11330	COG3629	intracellular signal transduction
SD37_RS11350	COG2133	pyrroloquinoline quinone binding
SD37_RS11360	COG0137	argininosuccinate synthase activity
SD37_RS11405	COG0702	epimerase
SD37_RS11420	COG3850	Histidine kinase
SD37_RS11420	COG5002	protein histidine kinase activity
SD37_RS11520	COG2197	response regulator
SD37_RS11900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_RS11900	COG1672	PFAM Archaeal ATPase
SD37_RS11910	COG0702	epimerase
SD37_RS11950	COG0300	oxidoreductase activity
SD37_RS11955	COG1316	TRANSCRIPTIONal
SD37_RS11965	COG1960	acyl-CoA dehydrogenase activity
SD37_RS11970	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_RS11980	COG1024	Enoyl-CoA hydratase
SD37_RS11985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SD37_RS11990	COG0583	DNA-binding transcription factor activity
SD37_RS11995	COG5002	protein histidine kinase activity
SD37_RS12000	COG0745	RESPONSE REGULATOR receiver
SD37_RS12010	COG2936	dipeptidyl-peptidase activity
SD37_RS12025	COG1733	regulation of RNA biosynthetic process
SD37_RS12030	COG2197	response regulator
SD37_RS12035	COG3851	Histidine kinase
SD37_RS12085	COG0779	Required for maturation of 30S ribosomal subunits
SD37_RS12125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SD37_RS12145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SD37_RS12165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SD37_RS12170	COG1185	polyribonucleotide nucleotidyltransferase activity
SD37_RS12180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SD37_RS12200	COG3214	Protein conserved in bacteria
SD37_RS12225	COG0515	serine threonine protein kinase
SD37_RS12230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_RS12235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SD37_RS12245	COG1113	amino acid transport
SD37_RS12275	COG0655	NAD(P)H dehydrogenase (quinone) activity
SD37_RS12285	COG1674	ftsk spoiiie
SD37_RS12305	COG0778	Nitroreductase
SD37_RS12310	COG0596	Alpha beta hydrolase
SD37_RS12320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SD37_RS12325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SD37_RS12335	COG1058	Belongs to the CinA family
SD37_RS12335	COG1546	Belongs to the CinA family
SD37_RS12340	COG1396	sequence-specific DNA binding
SD37_RS12350	COG1595	DNA-templated transcription, initiation
SD37_RS12355	COG1842	Phage shock protein A
SD37_RS12365	COG0154	amidase activity
SD37_RS12370	COG0167	dihydroorotate dehydrogenase activity
SD37_RS12380	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SD37_RS12385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SD37_RS12390	COG1192	Involved in chromosome partitioning
SD37_RS12395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_RS12400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SD37_RS12410	COG1305	Transglutaminase-like
SD37_RS12420	COG0714	Associated with various cellular activities
SD37_RS12470	COG2001	Belongs to the MraZ family
SD37_RS12475	COG0275	rRNA processing
SD37_RS12485	COG0768	penicillin binding
SD37_RS12500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SD37_RS12505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SD37_RS12515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SD37_RS12520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SD37_RS12525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SD37_RS12535	COG0702	epimerase
SD37_RS12580	COG0142	geranyltranstransferase activity
SD37_RS12650	COG0242	peptide deformylase activity
SD37_RS12655	COG1201	RNA secondary structure unwinding
SD37_RS12660	COG0443	Heat shock 70 kDa protein
SD37_RS12670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SD37_RS12675	COG2137	regulation of response to DNA damage stimulus
SD37_RS12695	COG0800	Aldolase
SD37_RS12715	COG1053	succinate dehydrogenase
SD37_RS12725	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_RS12735	COG0765	amino acid transport
SD37_RS12740	COG0765	amino acid transport
SD37_RS12745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_RS12750	COG1126	abc transporter atp-binding protein
SD37_RS12755	COG0745	RESPONSE REGULATOR receiver
SD37_RS12770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SD37_RS12785	COG1196	nuclear chromosome segregation
SD37_RS12795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SD37_RS12815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SD37_RS12825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SD37_RS12835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SD37_RS12840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SD37_RS12875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SD37_RS12885	COG1505	serine-type exopeptidase activity
SD37_RS12905	COG3387	PFAM Glycoside hydrolase 15-related
SD37_RS12920	COG0628	permease
SD37_RS12935	COG2197	response regulator
SD37_RS12945	COG2936	dipeptidyl-peptidase activity
SD37_RS12965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SD37_RS12980	COG0123	including yeast histone deacetylase and acetoin utilization protein
SD37_RS12995	COG1309	transcriptional regulator
SD37_RS13000	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS13005	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13010	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13020	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS13030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_RS13035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_RS13085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS13125	COG0003	Pfam Anion-transporting ATPase
SD37_RS13135	COG1940	carbohydrate kinase activity
SD37_RS13140	COG0494	nUDIX hydrolase
SD37_RS13145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_RS13170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SD37_RS13180	COG1228	amidohydrolase
SD37_RS13200	COG0640	Transcriptional regulator
SD37_RS13220	COG1946	Acyl-CoA thioesterase
SD37_RS13240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_RS13240	COG1672	PFAM Archaeal ATPase
SD37_RS13245	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS13265	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SD37_RS13280	COG1024	Enoyl-CoA hydratase
SD37_RS13295	COG1566	PFAM secretion protein HlyD family protein
SD37_RS13300	COG2814	Major facilitator Superfamily
SD37_RS13315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_RS13330	COG2018	Roadblock/LC7 domain
SD37_RS13360	COG1703	isobutyryl-CoA mutase activity
SD37_RS13360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SD37_RS13360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SD37_RS13370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS13375	COG1309	transcriptional regulator
SD37_RS13380	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SD37_RS13395	COG0657	acetylesterase activity
SD37_RS13420	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13445	COG0196	riboflavin kinase activity
SD37_RS13455	COG2030	dehydratase
SD37_RS13475	COG1053	succinate dehydrogenase
SD37_RS13485	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13490	COG2267	carboxylic ester hydrolase activity
SD37_RS13495	COG0346	lactoylglutathione lyase activity
SD37_RS13500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SD37_RS13530	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13535	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13540	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13545	COG1024	Enoyl-CoA hydratase
SD37_RS13550	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS13555	COG1960	acyl-CoA dehydrogenase activity
SD37_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS13565	COG1309	transcriptional regulator
SD37_RS13570	COG0183	Belongs to the thiolase family
SD37_RS13575	COG2814	Major facilitator Superfamily
SD37_RS13585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD37_RS13625	COG0110	maltose O-acetyltransferase activity
SD37_RS13640	COG0596	Alpha beta hydrolase
SD37_RS13660	COG1024	Enoyl-CoA hydratase
SD37_RS13670	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS13690	COG0183	Belongs to the thiolase family
SD37_RS13695	COG2124	cytochrome p450
SD37_RS13705	COG1295	ribonuclease BN
SD37_RS13740	COG2070	2-Nitropropane dioxygenase
SD37_RS13755	COG2188	Transcriptional regulator
SD37_RS13760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD37_RS13800	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SD37_RS13800	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SD37_RS13810	COG1490	D-aminoacyl-tRNA deacylase activity
SD37_RS13815	COG2890	protein-(glutamine-N5) methyltransferase activity
SD37_RS13840	COG2313	pseudouridylate synthase activity
SD37_RS13865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SD37_RS13880	COG4213	ABC transporter substrate-binding protein
SD37_RS13890	COG4214	carbohydrate transport
SD37_RS13900	COG1309	transcriptional regulator
SD37_RS13925	COG0531	amino acid
SD37_RS13930	COG2197	response regulator
SD37_RS13975	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS13995	COG0483	inositol monophosphate 1-phosphatase activity
SD37_RS14015	COG0756	dUTP diphosphatase activity
SD37_RS14045	COG0569	domain protein
SD37_RS14050	COG0531	amino acid
SD37_RS14055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SD37_RS14080	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS14085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SD37_RS14095	COG1309	transcriptional regulator
SD37_RS14100	COG0300	oxidoreductase activity
SD37_RS14110	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS14125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_RS14135	COG0745	RESPONSE REGULATOR receiver
SD37_RS14140	COG2205	protein histidine kinase activity
SD37_RS14145	COG0656	L-ascorbic acid biosynthetic process
SD37_RS14165	COG1024	Enoyl-CoA hydratase
SD37_RS14165	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_RS14170	COG0183	Belongs to the thiolase family
SD37_RS14175	COG2367	Beta-lactamase
SD37_RS14210	COG3665	Urea carboxylase-associated protein
SD37_RS14220	COG0531	amino acid
SD37_RS14225	COG1309	transcriptional regulator
SD37_RS14235	COG2197	response regulator
SD37_RS14245	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SD37_RS14255	COG3253	May function as heme-dependent peroxidase
SD37_RS14260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SD37_RS14270	COG3220	belongs to the UPF0276 family
SD37_RS14285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SD37_RS14295	COG2815	serine threonine protein kinase
SD37_RS14295	COG0515	serine threonine protein kinase
SD37_RS14305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD37_RS14325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS14330	COG0539	negative regulation of cytoplasmic translation
SD37_RS14335	COG2508	Transcriptional regulator
SD37_RS14335	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD37_RS14340	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS14345	COG0506	proline dehydrogenase activity
SD37_RS14350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD37_RS14365	COG1793	dna ligase
SD37_RS14410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SD37_RS14430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SD37_RS14450	COG1252	NADH dehydrogenase
SD37_RS14460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SD37_RS14465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SD37_RS14490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SD37_RS14550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SD37_RS14565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SD37_RS14570	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SD37_RS14575	COG1309	transcriptional regulator
SD37_RS14600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD37_RS14610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD37_RS14615	COG1263	PTS System
SD37_RS14620	COG2188	Transcriptional regulator
SD37_RS14625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD37_RS14660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SD37_RS14665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SD37_RS14675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SD37_RS14680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SD37_RS14685	COG0346	lactoylglutathione lyase activity
SD37_RS14700	COG0006	proline dipeptidase activity
SD37_RS14705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SD37_RS14710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SD37_RS14720	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SD37_RS14725	COG0540	Belongs to the ATCase OTCase family
SD37_RS14740	COG0505	Belongs to the CarA family
SD37_RS14750	COG0284	orotidine-5'-phosphate decarboxylase activity
SD37_RS14760	COG0194	GDP metabolic process
SD37_RS14765	COG1758	RNA polymerase activity
SD37_RS14775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SD37_RS14780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SD37_RS14790	COG0405	Gamma-glutamyltransferase
SD37_RS14795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SD37_RS14815	COG2197	response regulator
SD37_RS14820	COG4585	Histidine kinase
SD37_RS14835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_RS14835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_RS14840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SD37_RS14860	COG0322	excinuclease ABC activity
SD37_RS14865	COG1660	Displays ATPase and GTPase activities
SD37_RS14875	COG1481	regulation of sporulation
SD37_RS14890	COG0463	Glycosyl transferase, family 2
SD37_RS14900	COG1309	transcriptional regulator
SD37_RS14910	COG3250	beta-galactosidase activity
SD37_RS14960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SD37_RS14965	COG0126	phosphoglycerate kinase activity
SD37_RS14970	COG0149	triose-phosphate isomerase activity
SD37_RS14995	COG0363	glucosamine-6-phosphate deaminase activity
SD37_RS15010	COG0166	Belongs to the GPI family
SD37_RS15015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SD37_RS15025	COG0109	protoheme IX farnesyltransferase activity
SD37_RS15065	COG1612	heme a metabolic process
SD37_RS15100	COG0396	ATPase activity
SD37_RS15115	COG2151	metal-sulfur cluster biosynthetic enzyme
SD37_RS15120	COG1742	UPF0060 membrane protein
SD37_RS15150	COG2197	response regulator
SD37_RS15195	COG2200	EAL domain
SD37_RS15195	COG2199	diguanylate cyclase activity
SD37_RS15220	COG0488	(ABC) transporter
SD37_RS15235	COG1132	(ABC) transporter
SD37_RS15245	COG4821	SIS domain
SD37_RS15255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_RS15260	COG1316	TRANSCRIPTIONal
SD37_RS15285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SD37_RS15295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SD37_RS15295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SD37_RS15305	COG1024	Enoyl-CoA hydratase
SD37_RS15335	COG1960	acyl-CoA dehydrogenase activity
SD37_RS15340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_RS15360	COG1309	transcriptional regulator
SD37_RS15385	COG3469	chitinase activity
SD37_RS15405	COG0477	Major facilitator Superfamily
SD37_RS15410	COG1309	transcriptional regulator
SD37_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS15435	COG1024	Enoyl-CoA hydratase
SD37_RS15440	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS15445	COG1309	transcriptional regulator
SD37_RS15455	COG1960	acyl-CoA dehydrogenase activity
SD37_RS15460	COG1960	acyl-CoA dehydrogenase activity
SD37_RS15465	COG1960	acyl-CoA dehydrogenase activity
SD37_RS15500	COG0484	heat shock protein binding
SD37_RS15520	COG0531	amino acid
SD37_RS15525	COG1940	carbohydrate kinase activity
SD37_RS15530	COG0431	NADPH-dependent FMN reductase
SD37_RS15550	COG2124	cytochrome p450
SD37_RS15565	COG2267	carboxylic ester hydrolase activity
SD37_RS15575	COG0564	pseudouridine synthase activity
SD37_RS15590	COG1846	Transcriptional regulator
SD37_RS15605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS15610	COG0477	Major facilitator Superfamily
SD37_RS15620	COG1793	dna ligase
SD37_RS15645	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SD37_RS15670	COG0739	heme binding
SD37_RS15685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD37_RS15685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_RS15700	COG2814	Major facilitator Superfamily
SD37_RS15705	COG2855	membrane
SD37_RS15715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SD37_RS15725	COG0439	Biotin carboxylase
SD37_RS15735	COG3706	GGDEF domain
SD37_RS15775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SD37_RS15780	COG0328	RNA-DNA hybrid ribonuclease activity
SD37_RS15795	COG2205	protein histidine kinase activity
SD37_RS15800	COG0745	RESPONSE REGULATOR receiver
SD37_RS15810	COG3706	GGDEF domain
SD37_RS15820	COG3903	Transcriptional regulator
SD37_RS15820	COG3629	intracellular signal transduction
SD37_RS15825	COG0697	spore germination
SD37_RS15860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS15890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS15895	COG1053	succinate dehydrogenase
SD37_RS15905	COG0154	amidase activity
SD37_RS15910	COG1414	Transcriptional regulator
SD37_RS15925	COG2124	cytochrome p450
SD37_RS15940	COG1733	regulation of RNA biosynthetic process
SD37_RS15945	COG1309	transcriptional regulator
SD37_RS15950	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS15955	COG0028	Belongs to the TPP enzyme family
SD37_RS16015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS16025	COG1573	uracil-dna glycosylase
SD37_RS16035	COG3655	Transcriptional regulator
SD37_RS16065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD37_RS16065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD37_RS16095	COG0017	Asparaginyl-tRNA synthetase
SD37_RS16100	COG0069	glutamate synthase activity
SD37_RS16110	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS16140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SD37_RS16145	COG1834	amidinotransferase
SD37_RS16150	COG0475	glutathione-regulated potassium exporter activity
SD37_RS16160	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS16205	COG0704	Plays a role in the regulation of phosphate uptake
SD37_RS16230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD37_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS16245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SD37_RS16245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SD37_RS16250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SD37_RS16255	COG2192	nodulation
SD37_RS16260	COG1088	dTDP-glucose 4,6-dehydratase activity
SD37_RS16280	COG0438	transferase activity, transferring glycosyl groups
SD37_RS16295	COG2890	protein-(glutamine-N5) methyltransferase activity
SD37_RS16310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_RS16315	COG0723	plastoquinol--plastocyanin reductase activity
SD37_RS16340	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_RS16355	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_RS16360	COG3835	regulator
SD37_RS16370	COG3903	Transcriptional regulator
SD37_RS16370	COG3629	intracellular signal transduction
SD37_RS16380	COG0515	serine threonine protein kinase
SD37_RS16410	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
SD37_RS16475	COG1120	ATPase activity
SD37_RS16480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SD37_RS16535	COG1609	Transcriptional regulator
SD37_RS16540	COG1129	ABC transporter
SD37_RS16545	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_RS16550	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_RS16565	COG3347	Dehydrogenase
SD37_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS16570	COG1070	Carbohydrate kinase
SD37_RS16580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_RS16580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_RS16595	COG2267	carboxylic ester hydrolase activity
SD37_RS16635	COG1131	(ABC) transporter
SD37_RS16640	COG1132	(ABC) transporter
SD37_RS16655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS16680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS16685	COG2197	response regulator
SD37_RS16690	COG4585	Histidine kinase
SD37_RS16700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_RS16715	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS16730	COG1716	ATPase activity
SD37_RS16745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD37_RS16775	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SD37_RS16805	COG0673	inositol 2-dehydrogenase activity
SD37_RS16820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SD37_RS16835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD37_RS16855	COG0175	sulfate reduction
SD37_RS16860	COG2895	sulfate adenylyltransferase (ATP) activity
SD37_RS16910	COG3629	intracellular signal transduction
SD37_RS16910	COG3903	Transcriptional regulator
SD37_RS16920	COG2318	DinB family
SD37_RS16940	COG2226	methyltransferase
SD37_RS16975	COG3321	synthase
SD37_RS16975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS16975	COG0300	oxidoreductase activity
SD37_RS16975	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS16975	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS17025	COG0583	DNA-binding transcription factor activity
SD37_RS17055	COG3629	intracellular signal transduction
SD37_RS17055	COG3903	Transcriptional regulator
SD37_RS17125	COG2508	Transcriptional regulator
SD37_RS17125	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD37_RS17210	COG0667	Aldo Keto reductase
SD37_RS17240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS17255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SD37_RS17310	COG1082	Xylose isomerase domain protein TIM barrel
SD37_RS17330	COG2226	methyltransferase
SD37_RS17340	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SD37_RS17345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_RS17395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SD37_RS17405	COG0494	nUDIX hydrolase
SD37_RS17435	COG1857	crispr-associated protein
SD37_RS17465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS17475	COG1960	acyl-CoA dehydrogenase activity
SD37_RS17490	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SD37_RS17495	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS17520	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SD37_RS17520	COG3291	Pkd domain containing protein
SD37_RS17525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD37_RS17550	COG0583	DNA-binding transcription factor activity
SD37_RS17595	COG2367	Beta-lactamase
SD37_RS17610	COG2326	polyphosphate kinase activity
SD37_RS17625	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS17635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_RS17675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SD37_RS17680	COG0247	lactate metabolic process
SD37_RS17680	COG0277	FAD linked oxidase domain protein
SD37_RS17685	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD37_RS17690	COG2132	Multicopper oxidase
SD37_RS17700	COG0583	DNA-binding transcription factor activity
SD37_RS17740	COG3903	Transcriptional regulator
SD37_RS17740	COG3629	intracellular signal transduction
SD37_RS17810	COG0673	inositol 2-dehydrogenase activity
SD37_RS17850	COG2080	2 iron, 2 sulfur cluster binding
SD37_RS17855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SD37_RS17860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SD37_RS17870	COG1609	Transcriptional regulator
SD37_RS17885	COG3833	ABC-type maltose transport systems, permease component
SD37_RS17910	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SD37_RS17915	COG0714	Associated with various cellular activities
SD37_RS17950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SD37_RS18000	COG1609	Transcriptional regulator
SD37_RS18025	COG1609	Transcriptional regulator
SD37_RS18040	COG0395	ABC-type sugar transport system, permease component
SD37_RS18045	COG4209	transmembrane transport
SD37_RS18055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD37_RS18065	COG0667	Aldo Keto reductase
SD37_RS18100	COG1764	response to oxidative stress
SD37_RS18105	COG3629	intracellular signal transduction
SD37_RS18105	COG3903	Transcriptional regulator
SD37_RS18135	COG0477	Major facilitator Superfamily
SD37_RS18145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SD37_RS18150	COG1082	Xylose isomerase domain protein TIM barrel
SD37_RS18150	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SD37_RS18175	COG2197	response regulator
SD37_RS18185	COG1414	Transcriptional regulator
SD37_RS18190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SD37_RS18195	COG0277	FAD linked oxidase domain protein
SD37_RS18200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS18220	COG0745	RESPONSE REGULATOR receiver
SD37_RS18225	COG2205	protein histidine kinase activity
SD37_RS18295	COG0701	Predicted permease
SD37_RS18310	COG1802	Transcriptional regulator
SD37_RS18315	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS18330	COG0667	Aldo Keto reductase
SD37_RS18340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SD37_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS18365	COG0601	transmembrane transport
SD37_RS18370	COG0747	negative chemotaxis
SD37_RS18385	COG0657	acetylesterase activity
SD37_RS18395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SD37_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS18450	COG4977	sequence-specific DNA binding
SD37_RS18465	COG1253	flavin adenine dinucleotide binding
SD37_RS18470	COG0129	dihydroxy-acid dehydratase activity
SD37_RS18495	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_RS18510	COG0277	FAD linked oxidase domain protein
SD37_RS18515	COG0583	DNA-binding transcription factor activity
SD37_RS18520	COG0006	proline dipeptidase activity
SD37_RS18545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_RS18550	COG3938	Belongs to the proline racemase family
SD37_RS18555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SD37_RS18565	COG0477	Major facilitator Superfamily
SD37_RS18635	COG1414	Transcriptional regulator
SD37_RS18645	COG0778	Nitroreductase
SD37_RS18650	COG0583	DNA-binding transcription factor activity
SD37_RS18670	COG0154	amidase activity
SD37_RS18730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_RS18740	COG2124	cytochrome p450
SD37_RS18745	COG2124	cytochrome p450
SD37_RS18775	COG2197	response regulator
SD37_RS18780	COG4585	Histidine kinase
SD37_RS18805	COG1595	DNA-templated transcription, initiation
SD37_RS18815	COG1024	Enoyl-CoA hydratase
SD37_RS18825	COG0488	(ABC) transporter
SD37_RS18830	COG0395	ABC-type sugar transport system, permease component
SD37_RS18860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SD37_RS18885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SD37_RS18890	COG1132	(ABC) transporter
SD37_RS18895	COG1132	(ABC) transporter
SD37_RS18900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_RS18905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_RS18920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_RS18925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS18955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS18995	COG0640	Transcriptional regulator
SD37_RS19015	COG0523	cobalamin synthesis protein
SD37_RS19025	COG0254	rRNA binding
SD37_RS19035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SD37_RS19040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SD37_RS19045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SD37_RS19050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SD37_RS19060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SD37_RS19060	COG1648	precorrin-2 dehydrogenase activity
SD37_RS19075	COG1024	Enoyl-CoA hydratase
SD37_RS19080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_RS19095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SD37_RS19135	COG0509	glycine decarboxylation via glycine cleavage system
SD37_RS19140	COG1716	ATPase activity
SD37_RS19165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD37_RS19165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD37_RS19180	COG0656	L-ascorbic acid biosynthetic process
SD37_RS19230	COG2267	carboxylic ester hydrolase activity
SD37_RS19240	COG0583	DNA-binding transcription factor activity
SD37_RS19245	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_RS19250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SD37_RS19255	COG0121	glutamine amidotransferase
SD37_RS19260	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SD37_RS19285	COG0477	Major facilitator Superfamily
SD37_RS19290	COG0583	DNA-binding transcription factor activity
SD37_RS19300	COG1285	pathogenesis
SD37_RS19310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SD37_RS19315	COG3883	PFAM NLP P60 protein
SD37_RS19315	COG0791	NLP P60 protein
SD37_RS19320	COG0746	molybdenum cofactor guanylyltransferase activity
SD37_RS19330	COG0714	Associated with various cellular activities
SD37_RS19340	COG2304	oxidoreductase activity
SD37_RS19345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SD37_RS19350	COG3540	Alkaline phosphatase
SD37_RS19375	COG2205	protein histidine kinase activity
SD37_RS19380	COG0745	RESPONSE REGULATOR receiver
SD37_RS19385	COG0477	Major facilitator Superfamily
SD37_RS19395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SD37_RS19415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SD37_RS19420	COG3226	Transcriptional regulator
SD37_RS19425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_RS19440	COG4585	Histidine kinase
SD37_RS19465	COG0789	Transcriptional regulator
SD37_RS19470	COG0215	cysteine-tRNA ligase activity
SD37_RS19475	COG0488	(ABC) transporter
SD37_RS19480	COG1846	Transcriptional regulator
SD37_RS19495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SD37_RS19505	COG1410	methionine synthase
SD37_RS19505	COG0646	methionine synthase
SD37_RS19510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD37_RS19525	COG0140	phosphoribosyl-ATP diphosphatase activity
SD37_RS19530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SD37_RS19535	COG1192	Involved in chromosome partitioning
SD37_RS19550	COG0517	IMP dehydrogenase activity
SD37_RS19550	COG1994	Peptidase M50
SD37_RS19570	COG1222	aaa ATPase
SD37_RS19610	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SD37_RS19615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SD37_RS19630	COG1597	lipid kinase activity
SD37_RS19635	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SD37_RS19655	COG0640	Transcriptional regulator
SD37_RS19670	COG1733	regulation of RNA biosynthetic process
SD37_RS19680	COG2378	regulation of single-species biofilm formation
SD37_RS19690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SD37_RS19700	COG1597	lipid kinase activity
SD37_RS19730	COG4552	Acetyltransferase involved in intracellular survival and related
SD37_RS19800	COG4221	oxidoreductase activity
SD37_RS19805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_RS19835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_RS19840	COG2362	D-Aminopeptidase
SD37_RS19850	COG0488	(ABC) transporter
SD37_RS19875	COG1595	DNA-templated transcription, initiation
SD37_RS19885	COG0183	Belongs to the thiolase family
SD37_RS19935	COG0601	transmembrane transport
SD37_RS19945	COG4172	Belongs to the ABC transporter superfamily
SD37_RS19965	COG1619	proteins homologs of microcin C7 resistance protein MccF
SD37_RS20020	COG0640	Transcriptional regulator
SD37_RS20030	COG1309	transcriptional regulator
SD37_RS20040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS20065	COG0235	Class ii aldolase
SD37_RS20070	COG3395	kinase activity
SD37_RS20080	COG3622	Belongs to the hyi family
SD37_RS20085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD37_RS20095	COG0596	Alpha beta hydrolase
SD37_RS20105	COG0583	DNA-binding transcription factor activity
SD37_RS20110	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS20130	COG4974	Belongs to the 'phage' integrase family
SD37_RS20140	COG0590	tRNA wobble adenosine to inosine editing
SD37_RS20150	COG1522	sequence-specific DNA binding
SD37_RS20160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_RS20190	COG0477	Major facilitator Superfamily
SD37_RS20200	COG2226	methyltransferase
SD37_RS20210	COG0596	Alpha beta hydrolase
SD37_RS20240	COG2755	lipolytic protein G-D-S-L family
SD37_RS20250	COG1357	PFAM Pentapeptide repeats (8 copies)
SD37_RS20255	COG4221	oxidoreductase activity
SD37_RS20270	COG0702	epimerase
SD37_RS20285	COG4941	Belongs to the sigma-70 factor family
SD37_RS20325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SD37_RS20345	COG1960	acyl-CoA dehydrogenase activity
SD37_RS20350	COG1309	transcriptional regulator
SD37_RS20360	COG1595	DNA-templated transcription, initiation
SD37_RS20365	COG2318	DinB family
SD37_RS20370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SD37_RS20375	COG2890	protein-(glutamine-N5) methyltransferase activity
SD37_RS20380	COG2226	methyltransferase
SD37_RS20385	COG2226	methyltransferase
SD37_RS20395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SD37_RS20420	COG1435	thymidine kinase activity
SD37_RS20430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_RS20450	COG0463	Glycosyl transferase, family 2
SD37_RS20460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD37_RS20480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SD37_RS20510	COG1278	Cold shock
SD37_RS20520	COG0477	Major facilitator Superfamily
SD37_RS20535	COG1982	Orn Lys Arg decarboxylase major
SD37_RS20550	COG0587	DNA-directed DNA polymerase activity
SD37_RS20575	COG2197	response regulator
SD37_RS20595	COG2814	Major facilitator Superfamily
SD37_RS20615	COG3345	alpha-galactosidase
SD37_RS20640	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS20655	COG0395	ABC-type sugar transport system, permease component
SD37_RS20660	COG1175	transmembrane transport
SD37_RS20685	COG0259	pyridoxamine-phosphate oxidase activity
SD37_RS20715	COG0387	Pfam Sodium calcium exchanger
SD37_RS20720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SD37_RS20730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_RS20735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_RS20735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_RS20740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_RS20755	COG2226	methyltransferase
SD37_RS20775	COG0395	ABC-type sugar transport system, permease component
SD37_RS20780	COG1175	transmembrane transport
SD37_RS20790	COG1609	Transcriptional regulator
SD37_RS20795	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_RS20805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SD37_RS20830	COG0697	spore germination
SD37_RS20840	COG2084	Dehydrogenase
SD37_RS20860	COG1136	(ABC) transporter
SD37_RS20865	COG1136	(ABC) transporter
SD37_RS20875	COG3537	Alpha-1,2-mannosidase
SD37_RS20880	COG0477	Major facilitator Superfamily
SD37_RS20890	COG1595	DNA-templated transcription, initiation
SD37_RS20930	COG1846	Transcriptional regulator
SD37_RS20935	COG0039	L-malate dehydrogenase activity
SD37_RS20945	COG0789	Transcriptional regulator
SD37_RS20980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS20985	COG1104	cysteine desulfurase activity
SD37_RS20990	COG0339	signal peptide processing
SD37_RS21000	COG1968	undecaprenyl-diphosphatase activity
SD37_RS21005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS21010	COG0667	Aldo Keto reductase
SD37_RS21040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_RS21065	COG0739	heme binding
SD37_RS21080	COG3540	Alkaline phosphatase
SD37_RS21105	COG4585	Histidine kinase
SD37_RS21145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD37_RS21190	COG1295	ribonuclease BN
SD37_RS21205	COG2197	response regulator
SD37_RS21205	COG3903	Transcriptional regulator
SD37_RS21225	COG3404	Formiminotransferase-cyclodeaminase
SD37_RS21230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SD37_RS21240	COG2264	protein methyltransferase activity
SD37_RS21355	COG0596	Alpha beta hydrolase
SD37_RS21365	COG2115	Belongs to the xylose isomerase family
SD37_RS21370	COG1940	carbohydrate kinase activity
SD37_RS21370	COG1846	Transcriptional regulator
SD37_RS21400	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD37_RS21420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SD37_RS21475	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_RS21480	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_RS21485	COG1129	ABC transporter
SD37_RS21495	COG1609	Transcriptional regulator
SD37_RS21500	COG4585	Histidine kinase
SD37_RS21505	COG2197	response regulator
SD37_RS21540	COG1136	(ABC) transporter
SD37_RS21545	COG4977	sequence-specific DNA binding
SD37_RS21565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_RS21565	COG1672	PFAM Archaeal ATPase
SD37_RS21615	COG0745	RESPONSE REGULATOR receiver
SD37_RS21635	COG0444	Belongs to the ABC transporter superfamily
SD37_RS21645	COG4166	transmembrane transport
SD37_RS21670	COG2508	Transcriptional regulator
SD37_RS21670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD37_RS21675	COG4948	Mandelate Racemase Muconate Lactonizing
SD37_RS21690	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SD37_RS21695	COG2723	6-phospho-beta-galactosidase activity
SD37_RS21700	COG0395	ABC-type sugar transport system, permease component
SD37_RS21705	COG1175	transmembrane transport
SD37_RS21735	COG1733	regulation of RNA biosynthetic process
SD37_RS21755	COG2814	Major facilitator Superfamily
SD37_RS21760	COG2755	lipolytic protein G-D-S-L family
SD37_RS21760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SD37_RS21765	COG5002	protein histidine kinase activity
SD37_RS21770	COG0745	RESPONSE REGULATOR receiver
SD37_RS21775	COG5297	Belongs to the glycosyl hydrolase family 6
SD37_RS21800	COG0395	ABC-type sugar transport system, permease component
SD37_RS21805	COG1175	transmembrane transport
SD37_RS21810	COG1609	Transcriptional regulator
SD37_RS21815	COG0702	epimerase
SD37_RS21820	COG1846	Transcriptional regulator
SD37_RS21825	COG2409	Drug exporters of the RND superfamily
SD37_RS21850	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SD37_RS21875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SD37_RS21905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SD37_RS21925	COG1414	Transcriptional regulator
SD37_RS21930	COG0477	Major facilitator Superfamily
SD37_RS21955	COG3971	2-oxopent-4-enoate hydratase activity
SD37_RS21965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SD37_RS21970	COG5297	Belongs to the glycosyl hydrolase family 6
SD37_RS21970	COG4733	cellulase activity
SD37_RS21985	COG1733	regulation of RNA biosynthetic process
SD37_RS21990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SD37_RS22010	COG3250	beta-galactosidase activity
SD37_RS22015	COG3940	Belongs to the glycosyl hydrolase 43 family
SD37_RS22030	COG4214	carbohydrate transport
SD37_RS22035	COG1129	ABC transporter
SD37_RS22040	COG4213	ABC transporter substrate-binding protein
SD37_RS22045	COG2160	L-arabinose isomerase activity
SD37_RS22060	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_RS22065	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_RS22075	COG1879	ABC-type sugar transport system periplasmic component
SD37_RS22080	COG1609	Transcriptional regulator
SD37_RS22110	COG0395	ABC-type sugar transport system, permease component
SD37_RS22115	COG2723	6-phospho-beta-galactosidase activity
SD37_RS22120	COG0488	(ABC) transporter
SD37_RS22155	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS22175	COG1090	epimerase
SD37_RS22180	COG1309	transcriptional regulator
SD37_RS22190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_RS22215	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS22220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_RS22225	COG2197	response regulator
SD37_RS22235	COG4977	sequence-specific DNA binding
SD37_RS22275	COG2201	protein-glutamate methylesterase activity
SD37_RS22320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SD37_RS22340	COG1522	sequence-specific DNA binding
SD37_RS22345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SD37_RS22355	COG1793	dna ligase
SD37_RS22355	COG3285	dna ligase
SD37_RS22375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_RS22400	COG3960	tartronate-semialdehyde synthase activity
SD37_RS22405	COG2084	Dehydrogenase
SD37_RS22410	COG3622	Belongs to the hyi family
SD37_RS22415	COG0596	Alpha beta hydrolase
SD37_RS22435	COG1280	lysine exporter protein (LysE YggA)
SD37_RS22465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SD37_RS22480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SD37_RS22500	COG2018	Roadblock/LC7 domain
SD37_RS22525	COG3285	dna ligase
SD37_RS22525	COG1793	dna ligase
SD37_RS22550	COG3629	intracellular signal transduction
SD37_RS22550	COG3903	Transcriptional regulator
SD37_RS22575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_RS22580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SD37_RS22585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SD37_RS22600	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD37_RS22600	COG1024	Enoyl-CoA hydratase
SD37_RS22610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SD37_RS22615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SD37_RS22620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD37_RS22635	COG2255	four-way junction helicase activity
SD37_RS22640	COG0632	four-way junction helicase activity
SD37_RS22645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SD37_RS22660	COG0217	transcriptional regulatory protein
SD37_RS22665	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SD37_RS22690	COG1309	transcriptional regulator
SD37_RS22735	COG3903	Transcriptional regulator
SD37_RS22735	COG3629	intracellular signal transduction
SD37_RS22745	COG2040	homocysteine
SD37_RS22765	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SD37_RS22770	COG0277	FAD linked oxidase domain protein
SD37_RS22780	COG3608	succinylglutamate desuccinylase aspartoacylase
SD37_RS22780	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SD37_RS22790	COG0438	transferase activity, transferring glycosyl groups
SD37_RS22795	COG1560	Kdo2-lipid A biosynthetic process
SD37_RS22825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SD37_RS22830	COG0778	Nitroreductase
SD37_RS22895	COG2261	transglycosylase associated protein
SD37_RS22925	COG4249	Peptidase C14 caspase catalytic subunit p20
SD37_RS22925	COG2319	Wd-40 repeat
SD37_RS23025	COG0494	nUDIX hydrolase
SD37_RS23040	COG0515	serine threonine protein kinase
SD37_RS23040	COG2815	serine threonine protein kinase
SD37_RS23080	COG3629	intracellular signal transduction
SD37_RS23080	COG3903	Transcriptional regulator
SD37_RS23125	COG1960	acyl-CoA dehydrogenase activity
SD37_RS23135	COG2226	methyltransferase
SD37_RS23140	COG3509	depolymerase
SD37_RS23155	COG3507	Belongs to the glycosyl hydrolase 43 family
SD37_RS23165	COG3507	Belongs to the glycosyl hydrolase 43 family
SD37_RS23190	COG2197	response regulator
SD37_RS23195	COG4585	Histidine kinase
SD37_RS23265	COG0714	Associated with various cellular activities
SD37_RS23275	COG4221	oxidoreductase activity
SD37_RS23285	COG3693	PFAM glycoside hydrolase, family 10
SD37_RS23300	COG4941	Belongs to the sigma-70 factor family
SD37_RS23320	COG1132	(ABC) transporter
SD37_RS23325	COG4585	Histidine kinase
SD37_RS23330	COG2197	response regulator
SD37_RS23375	COG2197	response regulator
SD37_RS23380	COG4585	Histidine kinase
SD37_RS23385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SD37_RS23390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SD37_RS23440	COG2972	Histidine kinase
SD37_RS23440	COG2205	protein histidine kinase activity
SD37_RS23445	COG0745	RESPONSE REGULATOR receiver
SD37_RS23450	COG3033	Beta-eliminating lyase
SD37_RS23455	COG0475	glutathione-regulated potassium exporter activity
SD37_RS23490	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_RS23495	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_RS23500	COG1609	Transcriptional regulator
SD37_RS23510	COG1501	Belongs to the glycosyl hydrolase 31 family
SD37_RS23530	COG3250	beta-galactosidase activity
SD37_RS23535	COG0673	inositol 2-dehydrogenase activity
SD37_RS23545	COG3401	FG-GAP repeat protein
SD37_RS23560	COG3866	Pectate lyase
SD37_RS23570	COG0673	inositol 2-dehydrogenase activity
SD37_RS23580	COG0395	ABC-type sugar transport system, permease component
SD37_RS23585	COG1175	transmembrane transport
SD37_RS23595	COG1609	Transcriptional regulator
SD37_RS23605	COG1609	Transcriptional regulator
SD37_RS23610	COG1609	Transcriptional regulator
SD37_RS23660	COG4585	Histidine kinase
SD37_RS23665	COG2197	response regulator
SD37_RS23670	COG2197	response regulator
SD37_RS23710	COG1522	sequence-specific DNA binding
SD37_RS23720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SD37_RS23725	COG0596	Alpha beta hydrolase
SD37_RS23735	COG0706	membrane insertase activity
SD37_RS23760	COG0488	(ABC) transporter
SD37_RS23770	COG2815	serine threonine protein kinase
SD37_RS23770	COG0515	serine threonine protein kinase
SD37_RS23790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS23800	COG1819	glycosyl
SD37_RS23805	COG0300	oxidoreductase activity
SD37_RS23820	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS23825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS23825	COG3321	synthase
SD37_RS23830	COG0477	Major facilitator Superfamily
SD37_RS23845	COG0515	serine threonine protein kinase
SD37_RS23845	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SD37_RS23850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SD37_RS23850	COG0515	serine threonine protein kinase
SD37_RS23920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SD37_RS23945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_RS23980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD37_RS23990	COG0604	alcohol dehydrogenase
SD37_RS23990	COG3321	synthase
SD37_RS23995	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS24000	COG0667	Aldo Keto reductase
SD37_RS24025	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_RS24035	COG0477	Major facilitator Superfamily
SD37_RS24040	COG1959	2 iron, 2 sulfur cluster binding
SD37_RS24050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SD37_RS24055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD37_RS24065	COG1414	Transcriptional regulator
SD37_RS24070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD37_RS24095	COG3511	phospholipase C
SD37_RS24105	COG1335	isochorismatase
SD37_RS24120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_RS24125	COG2318	DinB family
SD37_RS24175	COG0583	DNA-binding transcription factor activity
SD37_RS24185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD37_RS24185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD37_RS24225	COG1309	transcriptional regulator
SD37_RS24250	COG2197	response regulator
SD37_RS24265	COG2072	flavoprotein involved in K transport
SD37_RS24270	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS24315	COG0583	DNA-binding transcription factor activity
SD37_RS24325	COG1063	alcohol dehydrogenase
SD37_RS24335	COG1064	alcohol dehydrogenase
SD37_RS24375	COG3629	intracellular signal transduction
SD37_RS24375	COG3903	Transcriptional regulator
SD37_RS24380	COG2197	response regulator
SD37_RS24385	COG4585	Histidine kinase
SD37_RS24390	COG2315	Protein conserved in bacteria
SD37_RS24405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_RS24410	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS24415	COG0028	Belongs to the TPP enzyme family
SD37_RS24440	COG1595	DNA-templated transcription, initiation
SD37_RS24450	COG2188	Transcriptional regulator
SD37_RS24465	COG3629	intracellular signal transduction
SD37_RS24465	COG3903	Transcriptional regulator
SD37_RS24470	COG0596	Alpha beta hydrolase
SD37_RS24485	COG4991	sh3 domain protein
SD37_RS24515	COG0500	methyltransferase
SD37_RS24550	COG4981	capsule polysaccharide biosynthetic process
SD37_RS24570	COG5001	Diguanylate cyclase
SD37_RS24590	COG3629	intracellular signal transduction
SD37_RS24590	COG3903	Transcriptional regulator
SD37_RS24600	COG0596	Alpha beta hydrolase
SD37_RS24605	COG5492	domain, Protein
SD37_RS24620	COG4948	Mandelate Racemase Muconate Lactonizing
SD37_RS24625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD37_RS24635	COG1414	Transcriptional regulator
SD37_RS24640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SD37_RS24700	COG1160	GTP binding
SD37_RS24725	COG0475	glutathione-regulated potassium exporter activity
SD37_RS24730	COG2936	dipeptidyl-peptidase activity
SD37_RS24740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SD37_RS24765	COG0494	nUDIX hydrolase
SD37_RS24770	COG0504	CTP synthase activity
SD37_RS24775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SD37_RS24785	COG1802	Transcriptional regulator
SD37_RS24790	COG1953	Uracil, thiamine, allantoin
SD37_RS24815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SD37_RS24830	COG0647	UMP catabolic process
SD37_RS24855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SD37_RS24860	COG2094	Belongs to the DNA glycosylase MPG family
SD37_RS24880	COG0165	Argininosuccinate lyase
SD37_RS24885	COG0137	argininosuccinate synthase activity
SD37_RS24890	COG1438	arginine binding
SD37_RS24895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SD37_RS24900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SD37_RS24905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SD37_RS24910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SD37_RS24915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SD37_RS24940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD37_RS24940	COG0072	phenylalanine-tRNA ligase activity
SD37_RS24945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SD37_RS24955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD37_RS24960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SD37_RS24965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SD37_RS24980	COG1802	Transcriptional regulator
SD37_RS25010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SD37_RS25015	COG2610	gluconate transmembrane transporter activity
SD37_RS25020	COG2706	6-phosphogluconolactonase activity
SD37_RS25030	COG1175	transmembrane transport
SD37_RS25035	COG0395	ABC-type sugar transport system, permease component
SD37_RS25065	COG0604	alcohol dehydrogenase
SD37_RS25065	COG3321	synthase
SD37_RS25075	COG4565	transcriptional regulatory protein
SD37_RS25080	COG3290	protein histidine kinase activity
SD37_RS25085	COG1301	dicarboxylic acid transport
SD37_RS25095	COG1733	regulation of RNA biosynthetic process
SD37_RS25140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD37_RS25230	COG3012	SEC-C Motif Domain Protein
SD37_RS25235	COG3250	beta-galactosidase activity
SD37_RS25275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD37_RS25280	COG1609	Transcriptional regulator
SD37_RS25295	COG0823	Involved in the tonB-independent uptake of proteins
SD37_RS25295	COG4946	Tricorn protease homolog
SD37_RS25295	COG1506	peptidase
SD37_RS25305	COG1131	(ABC) transporter
SD37_RS25320	COG1024	Enoyl-CoA hydratase
SD37_RS25365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SD37_RS25365	COG0237	dephospho-CoA kinase activity
SD37_RS25375	COG0539	negative regulation of cytoplasmic translation
SD37_RS25380	COG2226	methyltransferase
SD37_RS25400	COG1511	domain protein
SD37_RS25415	COG1653	transport
SD37_RS25450	COG0583	DNA-binding transcription factor activity
SD37_RS25490	COG0187	DNA topoisomerase II activity
SD37_RS25500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SD37_RS25505	COG1501	Belongs to the glycosyl hydrolase 31 family
SD37_RS25510	COG1349	DNA-binding transcription factor activity
SD37_RS25520	COG3842	ATPase activity
SD37_RS25525	COG0395	ABC-type sugar transport system, permease component
SD37_RS25530	COG1175	transmembrane transport
SD37_RS25550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD37_RS25580	COG2188	Transcriptional regulator
SD37_RS25600	COG2066	Belongs to the glutaminase family
SD37_RS25620	COG0583	DNA-binding transcription factor activity
SD37_RS25630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SD37_RS25680	COG3845	ABC transporter
SD37_RS25735	COG0559	Belongs to the binding-protein-dependent transport system permease family
SD37_RS25780	COG1846	Transcriptional regulator
SD37_RS25785	COG3665	Urea carboxylase-associated protein
SD37_RS25790	COG0446	pyridine nucleotide-disulphide oxidoreductase
SD37_RS25790	COG1902	pentaerythritol trinitrate reductase activity
SD37_RS25805	COG0515	serine threonine protein kinase
SD37_RS25810	COG0740	serine-type endopeptidase activity
SD37_RS25815	COG0740	serine-type endopeptidase activity
SD37_RS25820	COG1396	sequence-specific DNA binding
SD37_RS25880	COG2197	response regulator
SD37_RS25890	COG3903	Transcriptional regulator
SD37_RS25890	COG3629	intracellular signal transduction
SD37_RS25900	COG1595	DNA-templated transcription, initiation
SD37_RS25905	COG3629	intracellular signal transduction
SD37_RS25905	COG3903	Transcriptional regulator
SD37_RS25935	COG4941	Belongs to the sigma-70 factor family
SD37_RS25940	COG3795	YCII-related domain
SD37_RS25945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD37_RS26055	COG2197	response regulator
SD37_RS26060	COG3903	Transcriptional regulator
SD37_RS26060	COG3629	intracellular signal transduction
SD37_RS26070	COG2197	response regulator
SD37_RS26075	COG1819	glycosyl
SD37_RS26080	COG0702	epimerase
SD37_RS26085	COG0583	DNA-binding transcription factor activity
SD37_RS26095	COG0583	DNA-binding transcription factor activity
SD37_RS26100	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS26110	COG3546	catalase activity
SD37_RS26115	COG0473	3-isopropylmalate dehydrogenase activity
SD37_RS26125	COG2610	gluconate transmembrane transporter activity
SD37_RS26150	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS26155	COG0798	PFAM Bile acid sodium symporter
SD37_RS26160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SD37_RS26165	COG0640	Transcriptional regulator
SD37_RS26180	COG0583	DNA-binding transcription factor activity
SD37_RS26190	COG1733	regulation of RNA biosynthetic process
SD37_RS26200	COG0427	acetyl-CoA hydrolase
SD37_RS26225	COG3268	Saccharopine dehydrogenase
SD37_RS26260	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_RS26265	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_RS26270	COG2172	sigma factor antagonist activity
SD37_RS26285	COG0789	Transcriptional regulator
SD37_RS26285	COG4978	Transcriptional regulator
SD37_RS26300	COG1252	NADH dehydrogenase
SD37_RS26305	COG1595	DNA-templated transcription, initiation
SD37_RS26360	COG0142	geranyltranstransferase activity
SD37_RS26395	COG1247	-acetyltransferase
SD37_RS26410	COG3973	AAA domain
SD37_RS26415	COG2124	cytochrome p450
SD37_RS26430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_RS26440	COG1309	transcriptional regulator
SD37_RS26445	COG2318	DinB family
SD37_RS26450	COG3291	Pkd domain containing protein
SD37_RS26450	COG4447	cellulose binding
SD37_RS26450	COG5520	Belongs to the glycosyl hydrolase 30 family
SD37_RS26455	COG3629	intracellular signal transduction
SD37_RS26455	COG3903	Transcriptional regulator
SD37_RS26470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_RS26475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SD37_RS26480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SD37_RS26485	COG2423	ornithine cyclodeaminase activity
SD37_RS26495	COG1733	regulation of RNA biosynthetic process
SD37_RS26500	COG0028	Belongs to the TPP enzyme family
SD37_RS26530	COG2211	Major facilitator Superfamily
SD37_RS26535	COG0583	DNA-binding transcription factor activity
SD37_RS26580	COG1309	transcriptional regulator
SD37_RS26600	COG2197	response regulator
SD37_RS26630	COG0010	Belongs to the arginase family
SD37_RS26645	COG0604	alcohol dehydrogenase
SD37_RS26645	COG3321	synthase
SD37_RS26655	COG0604	alcohol dehydrogenase
SD37_RS26655	COG3321	synthase
SD37_RS26675	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS26685	COG2124	cytochrome p450
SD37_RS26695	COG1131	(ABC) transporter
SD37_RS26705	COG2311	Membrane
SD37_RS26720	COG0604	alcohol dehydrogenase
SD37_RS26725	COG2986	histidine ammonia-lyase
SD37_RS26730	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS26775	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
SD37_RS26790	COG0477	Major facilitator Superfamily
SD37_RS26810	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS26830	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SD37_RS26850	COG2197	response regulator
SD37_RS26855	COG4249	Peptidase C14 caspase catalytic subunit p20
SD37_RS26855	COG2319	Wd-40 repeat
SD37_RS26865	COG2814	Major facilitator Superfamily
SD37_RS26880	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SD37_RS26905	COG3629	intracellular signal transduction
SD37_RS26905	COG3903	Transcriptional regulator
SD37_RS26915	COG1032	radical SAM domain protein
SD37_RS26925	COG1366	Belongs to the anti-sigma-factor antagonist family
SD37_RS26925	COG2208	phosphoserine phosphatase activity
SD37_RS26925	COG2172	sigma factor antagonist activity
SD37_RS26960	COG1785	Belongs to the alkaline phosphatase family
SD37_RS26995	COG1595	DNA-templated transcription, initiation
SD37_RS27010	COG3237	CsbD-like
SD37_RS27015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_RS27025	COG1280	lysine exporter protein (LysE YggA)
SD37_RS27035	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SD37_RS27040	COG3903	Transcriptional regulator
SD37_RS27040	COG3629	intracellular signal transduction
SD37_RS27060	COG0640	Transcriptional regulator
SD37_RS27075	COG0596	Alpha beta hydrolase
SD37_RS27125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_RS27130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_RS27130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_RS27150	COG0640	Transcriptional regulator
SD37_RS27155	COG0514	ATP-dependent DNA helicase (RecQ)
SD37_RS27165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SD37_RS27185	COG0542	response to heat
SD37_RS27190	COG0477	Major facilitator Superfamily
SD37_RS27200	COG0667	Aldo Keto reductase
SD37_RS27220	COG0667	Aldo Keto reductase
SD37_RS27235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SD37_RS27235	COG2010	Cytochrome c
SD37_RS27250	COG1940	carbohydrate kinase activity
SD37_RS27275	COG1309	transcriptional regulator
SD37_RS27300	COG0248	Ppx GppA phosphatase
SD37_RS27305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS27325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SD37_RS27350	COG0640	Transcriptional regulator
SD37_RS27360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SD37_RS27390	COG3599	regulation of cell shape
SD37_RS27400	COG1799	cell septum assembly
SD37_RS27405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SD37_RS27410	COG1496	oxidoreductase activity
SD37_RS27415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SD37_RS27425	COG1595	DNA-templated transcription, initiation
SD37_RS27440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SD37_RS27450	COG2318	DinB family
SD37_RS27460	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SD37_RS27470	COG0596	Alpha beta hydrolase
SD37_RS27480	COG0069	glutamate synthase activity
SD37_RS27480	COG0070	glutamate synthase
SD37_RS27480	COG0067	glutamate synthase
SD37_RS27495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SD37_RS27500	COG1473	amidohydrolase
SD37_RS27515	COG0159	tryptophan synthase activity
SD37_RS27520	COG0133	tryptophan synthase activity
SD37_RS27525	COG0134	indole-3-glycerol-phosphate synthase activity
SD37_RS27535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SD37_RS27555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SD37_RS27565	COG0107	imidazoleglycerol-phosphate synthase activity
SD37_RS27570	COG1309	transcriptional regulator
SD37_RS27620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SD37_RS27625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SD37_RS27635	COG1960	acyl-CoA dehydrogenase activity
SD37_RS27650	COG3958	Transketolase
SD37_RS27655	COG3959	Transketolase, thiamine diphosphate binding domain
SD37_RS27665	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SD37_RS27670	COG1309	transcriptional regulator
SD37_RS27675	COG2409	Drug exporters of the RND superfamily
SD37_RS27695	COG0131	Imidazoleglycerol-phosphate dehydratase
SD37_RS27705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SD37_RS27715	COG1522	sequence-specific DNA binding
SD37_RS27720	COG3386	PFAM SMP-30 Gluconolaconase
SD37_RS27725	COG2197	response regulator
SD37_RS27775	COG1674	ftsk spoiiie
SD37_RS27785	COG3896	Chloramphenicol phosphotransferase-like protein
SD37_RS27835	COG1404	Belongs to the peptidase S8 family
SD37_RS27840	COG0157	Belongs to the NadC ModD family
SD37_RS27845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SD37_RS27850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SD37_RS27875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SD37_RS27880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SD37_RS27885	COG0659	secondary active sulfate transmembrane transporter activity
SD37_RS27890	COG0659	secondary active sulfate transmembrane transporter activity
SD37_RS27895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD37_RS27900	COG2124	cytochrome p450
SD37_RS27915	COG0438	transferase activity, transferring glycosyl groups
SD37_RS27970	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SD37_RS27985	COG1845	cytochrome c oxidase, subunit III
SD37_RS28030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SD37_RS28045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_RS28065	COG0667	Aldo Keto reductase
SD37_RS28075	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SD37_RS28090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SD37_RS28100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SD37_RS28120	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SD37_RS28165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD37_RS28170	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD37_RS28185	COG1090	epimerase
SD37_RS28195	COG0321	lipoyl(octanoyl) transferase activity
SD37_RS28220	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS28225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SD37_RS28230	COG0586	Pfam SNARE associated Golgi protein
SD37_RS28235	COG1752	Esterase of the alpha-beta hydrolase superfamily
SD37_RS28240	COG1376	ErfK ybiS ycfS ynhG family protein
SD37_RS28245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SD37_RS28270	COG0477	Major facilitator Superfamily
SD37_RS28275	COG0587	DNA-directed DNA polymerase activity
SD37_RS28295	COG1113	amino acid transport
SD37_RS28355	COG0456	acetyltransferase
SD37_RS28355	COG0454	-acetyltransferase
SD37_RS28395	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SD37_RS28405	COG3201	nicotinamide mononucleotide transporter
SD37_RS28410	COG0668	transmembrane transport
SD37_RS28425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SD37_RS28440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SD37_RS28465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD37_RS28475	COG0095	Lipoate-protein ligase
SD37_RS28485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SD37_RS28520	COG2197	response regulator
SD37_RS28530	COG1396	sequence-specific DNA binding
SD37_RS28560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SD37_RS28570	COG0442	prolyl-tRNA aminoacylation
SD37_RS28595	COG3022	response to hydroperoxide
SD37_RS28615	COG1404	Belongs to the peptidase S8 family
SD37_RS28645	COG0513	Belongs to the DEAD box helicase family
SD37_RS28650	COG0156	8-amino-7-oxononanoate synthase activity
SD37_RS28675	COG2807	transmembrane transport
SD37_RS28680	COG2186	Transcriptional regulator
SD37_RS28695	COG0454	-acetyltransferase
SD37_RS28695	COG0456	acetyltransferase
SD37_RS28700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SD37_RS28705	COG0750	zinc metalloprotease
SD37_RS28710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SD37_RS28725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SD37_RS28750	COG2755	lipolytic protein G-D-S-L family
SD37_RS28750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SD37_RS28760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS28770	COG2124	cytochrome p450
SD37_RS28795	COG1476	TRANSCRIPTIONal
SD37_RS28805	COG3540	Alkaline phosphatase
SD37_RS28835	COG0076	glutamate decarboxylase activity
SD37_RS28885	COG1595	DNA-templated transcription, initiation
SD37_RS28890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SD37_RS28900	COG1695	Transcriptional regulator
SD37_RS28930	COG0528	UMP kinase activity
SD37_RS28935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SD37_RS28940	COG0052	Belongs to the universal ribosomal protein uS2 family
SD37_RS28950	COG1191	sigma factor activity
SD37_RS28980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SD37_RS28985	COG0681	Belongs to the peptidase S26 family
SD37_RS28990	COG0335	large ribosomal subunit rRNA binding
SD37_RS28995	COG0336	Belongs to the RNA methyltransferase TrmD family
SD37_RS29010	COG0228	four-way junction DNA binding
SD37_RS29040	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SD37_RS29050	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SD37_RS29105	COG2873	o-acetylhomoserine
SD37_RS29110	COG1832	CoA-binding protein
SD37_RS29120	COG4266	Belongs to the allantoicase family
SD37_RS29125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD37_RS29140	COG2351	hydroxyisourate hydrolase activity
SD37_RS29155	COG1309	transcriptional regulator
SD37_RS29165	COG2252	PERMEase
SD37_RS29170	COG0590	tRNA wobble adenosine to inosine editing
SD37_RS29175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SD37_RS29195	COG3835	regulator
SD37_RS29205	COG1301	dicarboxylic acid transport
SD37_RS29235	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SD37_RS29240	COG1414	Transcriptional regulator
SD37_RS29250	COG0477	Major facilitator Superfamily
SD37_RS29265	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SD37_RS29300	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SD37_RS29305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SD37_RS29310	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SD37_RS29320	COG0367	asparagine synthase
SD37_RS29335	COG1131	(ABC) transporter
SD37_RS29340	COG1725	Transcriptional regulator
SD37_RS29345	COG3903	Transcriptional regulator
SD37_RS29345	COG3629	intracellular signal transduction
SD37_RS29355	COG0673	inositol 2-dehydrogenase activity
SD37_RS29360	COG1609	Transcriptional regulator
SD37_RS29365	COG1082	Xylose isomerase domain protein TIM barrel
SD37_RS29385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD37_RS29390	COG3718	enzyme involved in inositol metabolism
SD37_RS29395	COG3962	Belongs to the TPP enzyme family
SD37_RS29415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD37_RS29455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD37_RS29460	COG1522	sequence-specific DNA binding
SD37_RS29495	COG1414	Transcriptional regulator
SD37_RS29500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_RS29505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_RS29510	COG3485	protocatechuate 3,4-dioxygenase
SD37_RS29515	COG3485	protocatechuate 3,4-dioxygenase
SD37_RS29525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SD37_RS29530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SD37_RS29545	COG1929	Belongs to the glycerate kinase type-1 family
SD37_RS29595	COG2186	Transcriptional regulator
SD37_RS29600	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_RS29605	COG1129	ABC transporter
SD37_RS29620	COG4948	Mandelate Racemase Muconate Lactonizing
SD37_RS29625	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD37_RS29630	COG2814	Major facilitator Superfamily
SD37_RS29645	COG4221	oxidoreductase activity
SD37_RS29655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS29660	COG1120	ATPase activity
SD37_RS29665	COG4122	O-methyltransferase activity
SD37_RS29670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD37_RS29675	COG2186	Transcriptional regulator
SD37_RS29680	COG1760	l-serine dehydratase
SD37_RS29685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SD37_RS29690	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SD37_RS29695	COG0509	glycine decarboxylation via glycine cleavage system
SD37_RS29700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SD37_RS29705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD37_RS29705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD37_RS29720	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS29725	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SD37_RS29730	COG0174	glutamine synthetase
SD37_RS29755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS29790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SD37_RS29795	COG0571	ribonuclease III activity
SD37_RS29800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SD37_RS29830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SD37_RS29835	COG0742	ribosomal rna small subunit methyltransferase
SD37_RS29840	COG3973	AAA domain
SD37_RS29845	COG2319	Wd-40 repeat
SD37_RS29845	COG4249	Peptidase C14 caspase catalytic subunit p20
SD37_RS29850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS29860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_RS29885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SD37_RS29940	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SD37_RS29945	COG1404	Belongs to the peptidase S8 family
SD37_RS29990	COG1461	Dihydroxyacetone kinase
SD37_RS29995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SD37_RS30000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SD37_RS30005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SD37_RS30040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS30050	COG2205	protein histidine kinase activity
SD37_RS30055	COG0745	RESPONSE REGULATOR receiver
SD37_RS30080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD37_RS30085	COG0252	asparaginase activity
SD37_RS30095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SD37_RS30105	COG1920	GTP binding
SD37_RS30115	COG0406	alpha-ribazole phosphatase activity
SD37_RS30115	COG0494	nUDIX hydrolase
SD37_RS30120	COG3903	Transcriptional regulator
SD37_RS30120	COG3629	intracellular signal transduction
SD37_RS30125	COG0776	regulation of translation
SD37_RS30130	COG0066	3-isopropylmalate dehydratase activity
SD37_RS30135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SD37_RS30150	COG2378	regulation of single-species biofilm formation
SD37_RS30160	COG0745	RESPONSE REGULATOR receiver
SD37_RS30165	COG0464	growth
SD37_RS30175	COG0745	RESPONSE REGULATOR receiver
SD37_RS30180	COG2205	protein histidine kinase activity
SD37_RS30230	COG1674	ftsk spoiiie
SD37_RS30280	COG0714	Associated with various cellular activities
SD37_RS30320	COG0583	DNA-binding transcription factor activity
SD37_RS30340	COG1733	regulation of RNA biosynthetic process
SD37_RS30375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SD37_RS30410	COG1404	Belongs to the peptidase S8 family
SD37_RS30445	COG0583	DNA-binding transcription factor activity
SD37_RS30480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SD37_RS30540	COG1082	Xylose isomerase domain protein TIM barrel
SD37_RS30545	COG1401	restriction endodeoxyribonuclease activity
SD37_RS30585	COG4106	trans-aconitate 2-methyltransferase activity
SD37_RS30600	COG1595	DNA-templated transcription, initiation
SD37_RS30605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_RS30625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SD37_RS30635	COG2197	response regulator
SD37_RS30640	COG4585	Histidine kinase
SD37_RS30650	COG1131	(ABC) transporter
SD37_RS30655	COG0423	glycine-tRNA ligase activity
SD37_RS30690	COG0701	Predicted permease
SD37_RS30700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SD37_RS30705	COG1381	Involved in DNA repair and RecF pathway recombination
SD37_RS30720	COG1714	RDD family
SD37_RS30740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SD37_RS30755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SD37_RS30765	COG0537	adenosine 5'-monophosphoramidase activity
SD37_RS30780	COG0484	heat shock protein binding
SD37_RS30785	COG1420	regulation of RNA biosynthetic process
SD37_RS30815	COG2205	protein histidine kinase activity
SD37_RS30820	COG0745	RESPONSE REGULATOR receiver
SD37_RS30825	COG1953	Uracil, thiamine, allantoin
SD37_RS30835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD37_RS30845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_RS30905	COG0463	Glycosyl transferase, family 2
SD37_RS30915	COG2192	nodulation
SD37_RS30955	COG0175	sulfate reduction
SD37_RS30980	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SD37_RS30985	COG2732	(Barnase) inhibitor
SD37_RS31000	COG0604	alcohol dehydrogenase
SD37_RS31010	COG0583	DNA-binding transcription factor activity
SD37_RS31025	COG0531	amino acid
SD37_RS31030	COG2070	2-Nitropropane dioxygenase
SD37_RS31045	COG0481	GTPase activity
SD37_RS31050	COG2226	methyltransferase
SD37_RS31065	COG0268	Binds directly to 16S ribosomal RNA
SD37_RS31080	COG0658	competence protein
SD37_RS31080	COG2333	competence protein COMEC
SD37_RS31085	COG1555	photosystem II stabilization
SD37_RS31090	COG1307	EDD domain protein, DegV family
SD37_RS31100	COG0406	alpha-ribazole phosphatase activity
SD37_RS31105	COG0799	negative regulation of ribosome biogenesis
SD37_RS31110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SD37_RS31120	COG0477	Major facilitator Superfamily
SD37_RS31125	COG0018	arginyl-trna synthetase
SD37_RS31145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SD37_RS31150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SD37_RS31155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SD37_RS31160	COG1530	ribonuclease E activity
SD37_RS31170	COG0842	Transport permease protein
SD37_RS31180	COG1131	(ABC) transporter
SD37_RS31200	COG0105	UTP biosynthetic process
SD37_RS31210	COG2366	antibiotic biosynthetic process
SD37_RS31220	COG0285	dihydrofolate synthase activity
SD37_RS31235	COG0525	valine-tRNA ligase activity
SD37_RS31260	COG1316	TRANSCRIPTIONal
SD37_RS31275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SD37_RS31285	COG1309	transcriptional regulator
SD37_RS31305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SD37_RS31310	COG0740	serine-type endopeptidase activity
SD37_RS31320	COG0544	peptidyl-prolyl cis-trans isomerase activity
SD37_RS31325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SD37_RS31330	COG2205	protein histidine kinase activity
SD37_RS31335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_RS31340	COG0463	Glycosyl transferase, family 2
SD37_RS31345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD37_RS31380	COG2814	Major facilitator Superfamily
SD37_RS31405	COG2815	serine threonine protein kinase
SD37_RS31405	COG0515	serine threonine protein kinase
SD37_RS31420	COG0693	protein deglycase activity
SD37_RS31435	COG0784	Response regulator, receiver
SD37_RS31435	COG5002	protein histidine kinase activity
SD37_RS31490	COG4941	Belongs to the sigma-70 factor family
SD37_RS31500	COG3345	alpha-galactosidase
SD37_RS31525	COG0698	ribose 5-phosphate isomerase
SD37_RS31540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SD37_RS31550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SD37_RS31570	COG0668	transmembrane transport
SD37_RS31580	COG0366	Alpha amylase catalytic
SD37_RS31610	COG2902	Dehydrogenase
SD37_RS31645	COG0738	Major facilitator superfamily
SD37_RS31650	COG1609	Transcriptional regulator
SD37_RS31760	COG1309	transcriptional regulator
SD37_RS31780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_RS31795	COG1733	regulation of RNA biosynthetic process
SD37_RS31805	COG1113	amino acid transport
SD37_RS31815	COG1846	Transcriptional regulator
SD37_RS31830	COG1793	dna ligase
SD37_RS31830	COG3285	dna ligase
SD37_RS31835	COG1793	dna ligase
SD37_RS31835	COG3285	dna ligase
SD37_RS31850	COG1136	(ABC) transporter
SD37_RS31850	COG0577	efflux transmembrane transporter activity
SD37_RS31860	COG4585	Histidine kinase
SD37_RS31865	COG2197	response regulator
SD37_RS31880	COG0300	oxidoreductase activity
SD37_RS31900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_RS31905	COG2197	response regulator
SD37_RS31910	COG4977	sequence-specific DNA binding
SD37_RS31910	COG1917	Cupin 2, conserved barrel domain protein
SD37_RS31920	COG2197	response regulator
SD37_RS31930	COG1733	regulation of RNA biosynthetic process
SD37_RS31935	COG0009	L-threonylcarbamoyladenylate synthase
SD37_RS31945	COG2197	response regulator
SD37_RS31970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_RS31995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_RS32030	COG2124	cytochrome p450
SD37_RS32050	COG4977	sequence-specific DNA binding
SD37_RS32050	COG1917	Cupin 2, conserved barrel domain protein
SD37_RS32065	COG3629	intracellular signal transduction
SD37_RS32095	COG3795	YCII-related domain
SD37_RS32100	COG1937	Protein conserved in bacteria
SD37_RS32135	COG2267	carboxylic ester hydrolase activity
SD37_RS32140	COG4221	oxidoreductase activity
SD37_RS32150	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SD37_RS32175	COG0745	RESPONSE REGULATOR receiver
SD37_RS32180	COG2205	protein histidine kinase activity
SD37_RS32215	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS32230	COG0604	alcohol dehydrogenase
SD37_RS32230	COG3321	synthase
SD37_RS32245	COG0596	Alpha beta hydrolase
SD37_RS32290	COG1609	Transcriptional regulator
SD37_RS32305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SD37_RS32310	COG0745	RESPONSE REGULATOR receiver
SD37_RS32320	COG1136	(ABC) transporter
SD37_RS32325	COG4181	ATPase activity
SD37_RS32330	COG5002	protein histidine kinase activity
SD37_RS32410	COG1024	Enoyl-CoA hydratase
SD37_RS32455	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS32465	COG1643	Atp-dependent helicase
SD37_RS32475	COG0475	glutathione-regulated potassium exporter activity
SD37_RS32505	COG1796	DNA polymerase
SD37_RS32505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SD37_RS32515	COG1802	Transcriptional regulator
SD37_RS32535	COG3706	GGDEF domain
SD37_RS32540	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SD37_RS32545	COG0010	Belongs to the arginase family
SD37_RS32555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD37_RS32570	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SD37_RS32570	COG0235	Class ii aldolase
SD37_RS32585	COG4552	Acetyltransferase involved in intracellular survival and related
SD37_RS32600	COG1309	transcriptional regulator
SD37_RS32615	COG0277	FAD linked oxidase domain protein
SD37_RS32615	COG0247	lactate metabolic process
SD37_RS32625	COG2197	response regulator
SD37_RS32640	COG0559	Belongs to the binding-protein-dependent transport system permease family
SD37_RS32645	COG0559	Belongs to the binding-protein-dependent transport system permease family
SD37_RS32660	COG1522	sequence-specific DNA binding
SD37_RS32675	COG1739	Uncharacterized protein family UPF0029
SD37_RS32680	COG0069	glutamate synthase activity
SD37_RS32680	COG0070	glutamate synthase
SD37_RS32680	COG0067	glutamate synthase
SD37_RS32710	COG0300	oxidoreductase activity
SD37_RS32715	COG1492	cobalamin metabolic process
SD37_RS32720	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SD37_RS32730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SD37_RS32735	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SD37_RS32750	COG1797	cobyrinic acid a,c-diamide synthase activity
SD37_RS32790	COG3973	AAA domain
SD37_RS32795	COG4249	Peptidase C14 caspase catalytic subunit p20
SD37_RS32795	COG2319	Wd-40 repeat
SD37_RS32820	COG1131	(ABC) transporter
SD37_RS32830	COG1476	TRANSCRIPTIONal
SD37_RS32840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SD37_RS32840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SD37_RS32850	COG0488	(ABC) transporter
SD37_RS32855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SD37_RS32860	COG2151	metal-sulfur cluster biosynthetic enzyme
SD37_RS32865	COG3396	Phenylacetate-CoA oxygenase
SD37_RS32870	COG3460	Phenylacetate-CoA oxygenase
SD37_RS32875	COG3396	Phenylacetate-CoA oxygenase
SD37_RS32880	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS32880	COG2030	dehydratase
SD37_RS32895	COG1309	transcriptional regulator
SD37_RS32925	COG2072	flavoprotein involved in K transport
SD37_RS32940	COG2183	response to ionizing radiation
SD37_RS32955	COG0513	Belongs to the DEAD box helicase family
SD37_RS32965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD37_RS32980	COG4585	Histidine kinase
SD37_RS32985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SD37_RS32990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SD37_RS33000	COG3540	Alkaline phosphatase
SD37_RS33005	COG4991	sh3 domain protein
SD37_RS33010	COG3629	intracellular signal transduction
SD37_RS33010	COG3903	Transcriptional regulator
SD37_RS33015	COG4991	sh3 domain protein
SD37_RS33075	COG1131	(ABC) transporter
SD37_RS33080	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS33100	COG1126	abc transporter atp-binding protein
SD37_RS33105	COG0765	amino acid transport
SD37_RS33110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_RS33180	COG1116	anion transmembrane transporter activity
SD37_RS33190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD37_RS33270	COG1309	transcriptional regulator
SD37_RS33275	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS33280	COG0604	alcohol dehydrogenase
SD37_RS33300	COG3693	PFAM glycoside hydrolase, family 10
SD37_RS33310	COG0596	Alpha beta hydrolase
SD37_RS33345	COG0714	Associated with various cellular activities
SD37_RS33365	COG0515	serine threonine protein kinase
SD37_RS33365	COG2815	serine threonine protein kinase
SD37_RS33375	COG2205	protein histidine kinase activity
SD37_RS33380	COG0745	RESPONSE REGULATOR receiver
SD37_RS33385	COG3629	intracellular signal transduction
SD37_RS33385	COG3903	Transcriptional regulator
SD37_RS33410	COG1231	oxidoreductase activity
SD37_RS33415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SD37_RS33440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_RS33445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_RS33450	COG5001	Diguanylate cyclase
SD37_RS33460	COG2124	cytochrome p450
SD37_RS33490	COG1846	Transcriptional regulator
SD37_RS33495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD37_RS33560	COG0402	S-adenosylhomocysteine deaminase activity
SD37_RS33570	COG0574	Belongs to the PEP-utilizing enzyme family
SD37_RS33570	COG3848	Pyruvate phosphate dikinase
SD37_RS33585	COG0667	Aldo Keto reductase
SD37_RS33590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SD37_RS33595	COG1024	Enoyl-CoA hydratase
SD37_RS33600	COG1024	Enoyl-CoA hydratase
SD37_RS33605	COG1024	Enoyl-CoA hydratase
SD37_RS33610	COG3424	synthase
SD37_RS33615	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SD37_RS33635	COG0475	glutathione-regulated potassium exporter activity
SD37_RS33660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_RS33685	COG1819	glycosyl
SD37_RS33690	COG1819	glycosyl
SD37_RS33700	COG2124	cytochrome p450
SD37_RS33705	COG2124	cytochrome p450
SD37_RS33710	COG2124	cytochrome p450
SD37_RS33735	COG1132	(ABC) transporter
SD37_RS33755	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SD37_RS33760	COG1181	Belongs to the D-alanine--D-alanine ligase family
SD37_RS33855	COG3511	phospholipase C
SD37_RS33865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD37_RS33895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD37_RS33930	COG1132	(ABC) transporter
SD37_RS33935	COG4552	Acetyltransferase involved in intracellular survival and related
SD37_RS33955	COG2207	Transcriptional regulator
SD37_RS33980	COG2124	cytochrome p450
SD37_RS34020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SD37_RS34030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD37_RS34065	COG3291	Pkd domain containing protein
SD37_RS34090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SD37_RS34110	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD37_RS34115	COG1129	ABC transporter
SD37_RS34130	COG1940	carbohydrate kinase activity
SD37_RS34135	COG0477	Major facilitator Superfamily
SD37_RS34160	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS34180	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS34190	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SD37_RS34255	COG0367	asparagine synthase
SD37_RS34260	COG2197	response regulator
SD37_RS34265	COG2197	response regulator
SD37_RS34300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD37_RS34305	COG0475	glutathione-regulated potassium exporter activity
SD37_RS34310	COG4565	transcriptional regulatory protein
SD37_RS34315	COG3290	protein histidine kinase activity
SD37_RS34395	COG2255	four-way junction helicase activity
SD37_RS34415	COG2181	nitrate reductase activity
SD37_RS34415	COG0247	lactate metabolic process
SD37_RS34425	COG1121	(ABC) transporter
SD37_RS34430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SD37_RS34445	COG1120	ATPase activity
SD37_RS34460	COG0326	Molecular chaperone. Has ATPase activity
SD37_RS34475	COG3835	regulator
SD37_RS34490	COG0596	Alpha beta hydrolase
SD37_RS34530	COG2182	Extracellular solute-binding protein
SD37_RS34535	COG1175	transmembrane transport
SD37_RS34540	COG0395	ABC-type sugar transport system, permease component
SD37_RS34545	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_RS34555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS34560	COG2084	Dehydrogenase
SD37_RS34580	COG0483	inositol monophosphate 1-phosphatase activity
SD37_RS34590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD37_RS34605	COG0438	transferase activity, transferring glycosyl groups
SD37_RS34640	COG5001	Diguanylate cyclase
SD37_RS34645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD37_RS34665	COG3285	dna ligase
SD37_RS34665	COG1793	dna ligase
SD37_RS34705	COG0667	Aldo Keto reductase
SD37_RS34725	COG3795	YCII-related domain
SD37_RS34750	COG0187	DNA topoisomerase II activity
SD37_RS34755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SD37_RS34760	COG1960	acyl-CoA dehydrogenase activity
SD37_RS34765	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS34770	COG2030	dehydratase
SD37_RS34780	COG0183	Belongs to the thiolase family
SD37_RS34790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SD37_RS34790	COG0473	3-isopropylmalate dehydrogenase activity
SD37_RS34800	COG0583	DNA-binding transcription factor activity
SD37_RS34815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_RS34820	COG1643	Atp-dependent helicase
SD37_RS34830	COG1131	(ABC) transporter
SD37_RS34855	COG2197	response regulator
SD37_RS34860	COG4585	Histidine kinase
SD37_RS34875	COG1228	amidohydrolase
SD37_RS34880	COG0402	S-adenosylhomocysteine deaminase activity
SD37_RS34890	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SD37_RS34895	COG2986	histidine ammonia-lyase
SD37_RS34910	COG0596	Alpha beta hydrolase
SD37_RS34930	COG4585	Histidine kinase
SD37_RS34935	COG2197	response regulator
SD37_RS34955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SD37_RS34960	COG2177	Part of the ABC transporter FtsEX involved in
SD37_RS34965	COG2884	Cell division ATP-binding protein ftsE
SD37_RS34970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SD37_RS35000	COG1615	UPF0182 protein
SD37_RS35010	COG3480	Lon protease (S16) C-terminal proteolytic domain
SD37_RS35080	COG0174	glutamine synthetase
SD37_RS35090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SD37_RS35110	COG1522	sequence-specific DNA binding
SD37_RS35130	COG0154	amidase activity
SD37_RS35135	COG0174	glutamine synthetase
SD37_RS35160	COG0653	protein targeting
SD37_RS35165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SD37_RS35165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD37_RS35180	COG2318	DinB family
SD37_RS35185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SD37_RS35185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SD37_RS35190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SD37_RS35200	COG0596	Alpha beta hydrolase
SD37_RS35210	COG1177	transmembrane transport
SD37_RS35215	COG1176	ABC-type spermidine putrescine transport system, permease component I
SD37_RS35220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SD37_RS35225	COG3842	ATPase activity
SD37_RS35230	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS35255	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS35260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD37_RS35265	COG0557	exoribonuclease II activity
SD37_RS35355	COG2197	response regulator
SD37_RS35380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SD37_RS35410	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SD37_RS35420	COG3265	gluconokinase activity
SD37_RS35430	COG0640	Transcriptional regulator
SD37_RS35445	COG1486	melibiose metabolic process
SD37_RS35450	COG0395	ABC-type sugar transport system, permease component
SD37_RS35455	COG1175	transmembrane transport
SD37_RS35480	COG0612	Peptidase, M16
SD37_RS35530	COG0714	Associated with various cellular activities
SD37_RS35580	COG0210	DNA helicase
SD37_RS35595	COG4585	Histidine kinase
SD37_RS35605	COG2378	regulation of single-species biofilm formation
SD37_RS35620	COG0745	RESPONSE REGULATOR receiver
SD37_RS35625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD37_RS35625	COG2146	nitrite reductase [NAD(P)H] activity
SD37_RS35630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD37_RS35630	COG2146	nitrite reductase [NAD(P)H] activity
SD37_RS35635	COG2223	nitrite transmembrane transporter activity
SD37_RS35640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD37_RS35645	COG0243	molybdopterin cofactor binding
SD37_RS35655	COG1136	(ABC) transporter
SD37_RS35685	COG0596	Alpha beta hydrolase
SD37_RS35695	COG0402	S-adenosylhomocysteine deaminase activity
SD37_RS35710	COG2267	carboxylic ester hydrolase activity
SD37_RS35745	COG0513	Belongs to the DEAD box helicase family
SD37_RS35770	COG2095	MarC family integral membrane protein
SD37_RS35775	COG0613	PHP domain protein
SD37_RS35800	COG0598	Magnesium transport protein CorA
SD37_RS35820	COG1309	transcriptional regulator
SD37_RS35885	COG0330	HflC and HflK could
SD37_RS35895	COG2239	Acts as a magnesium transporter
SD37_RS35910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SD37_RS35915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD37_RS35940	COG2814	Major facilitator Superfamily
SD37_RS35950	COG0671	phosphoesterase, PA-phosphatase related
SD37_RS35955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SD37_RS35965	COG1024	Enoyl-CoA hydratase
SD37_RS35975	COG0519	Catalyzes the synthesis of GMP from XMP
SD37_RS36010	COG1271	oxidase subunit
SD37_RS36015	COG1294	oxidase, subunit
SD37_RS36020	COG4988	ABC transporter
SD37_RS36025	COG1132	(ABC) transporter
SD37_RS36030	COG0463	Glycosyl transferase, family 2
SD37_RS36045	COG1611	Belongs to the LOG family
SD37_RS36050	COG3291	Pkd domain containing protein
SD37_RS36090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD37_RS36100	COG2171	N-acyltransferase activity
SD37_RS36140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SD37_RS36145	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SD37_RS36145	COG0778	Nitroreductase
SD37_RS36160	COG1725	Transcriptional regulator
SD37_RS36185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_RS36205	COG0438	transferase activity, transferring glycosyl groups
SD37_RS36235	COG1316	TRANSCRIPTIONal
SD37_RS36240	COG1316	TRANSCRIPTIONal
SD37_RS36250	COG2259	Doxx family
SD37_RS36320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SD37_RS36330	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS36335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SD37_RS36385	COG2197	response regulator
SD37_RS36390	COG2197	response regulator
SD37_RS36405	COG2205	protein histidine kinase activity
SD37_RS36415	COG0483	inositol monophosphate 1-phosphatase activity
SD37_RS36445	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SD37_RS36445	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SD37_RS36450	COG3103	Sh3 type 3 domain protein
SD37_RS36450	COG1388	LysM domain
SD37_RS36450	COG0791	NLP P60 protein
SD37_RS36455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SD37_RS36500	COG0640	Transcriptional regulator
SD37_RS36515	COG2249	NAD(P)H dehydrogenase (quinone) activity
SD37_RS36520	COG0655	NAD(P)H dehydrogenase (quinone) activity
SD37_RS36535	COG4585	Histidine kinase
SD37_RS36540	COG2197	response regulator
SD37_RS36545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD37_RS36580	COG1472	Belongs to the glycosyl hydrolase 3 family
SD37_RS36585	COG0424	maF-like protein
SD37_RS36590	COG1301	dicarboxylic acid transport
SD37_RS36605	COG4770	biotin carboxylase activity
SD37_RS36630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SD37_RS36635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SD37_RS36640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD37_RS36680	COG1473	amidohydrolase
SD37_RS36680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SD37_RS36705	COG0515	serine threonine protein kinase
SD37_RS36735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD37_RS36760	COG1228	amidohydrolase
SD37_RS36775	COG0667	Aldo Keto reductase
SD37_RS36780	COG0667	Aldo Keto reductase
SD37_RS36810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_RS36815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SD37_RS36820	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS36825	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS36845	COG0395	ABC-type sugar transport system, permease component
SD37_RS36860	COG1063	alcohol dehydrogenase
SD37_RS36865	COG2390	Transcriptional regulator
SD37_RS36870	COG1733	regulation of RNA biosynthetic process
SD37_RS36895	COG2271	Major facilitator Superfamily
SD37_RS36900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SD37_RS36920	COG1079	Belongs to the binding-protein-dependent transport system permease family
SD37_RS36930	COG3845	ABC transporter
SD37_RS36935	COG1744	ABC transporter substrate-binding protein PnrA-like
SD37_RS36940	COG3345	alpha-galactosidase
SD37_RS36955	COG2009	succinate dehydrogenase
SD37_RS36970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SD37_RS36985	COG1404	Belongs to the peptidase S8 family
SD37_RS36995	COG1686	Belongs to the peptidase S11 family
SD37_RS37000	COG1295	ribonuclease BN
SD37_RS37005	COG0180	Tryptophanyl-tRNA synthetase
SD37_RS37045	COG1234	tRNA 3'-trailer cleavage
SD37_RS37075	COG2264	protein methyltransferase activity
SD37_RS37095	COG0667	Aldo Keto reductase
SD37_RS37145	COG2814	Major facilitator Superfamily
SD37_RS37150	COG0640	Transcriptional regulator
SD37_RS37155	COG2814	Major facilitator Superfamily
SD37_RS37190	COG0587	DNA-directed DNA polymerase activity
SD37_RS37205	COG1073	alpha beta
SD37_RS37230	COG0138	bifunctional purine biosynthesis protein purh
SD37_RS37255	COG0045	succinate-CoA ligase (ADP-forming) activity
SD37_RS37270	COG0739	heme binding
SD37_RS37310	COG0515	serine threonine protein kinase
SD37_RS37315	COG0515	serine threonine protein kinase
SD37_RS37325	COG0583	DNA-binding transcription factor activity
SD37_RS37365	COG0519	Catalyzes the synthesis of GMP from XMP
SD37_RS37365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SD37_RS37380	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS37385	COG0277	FAD linked oxidase domain protein
SD37_RS37390	COG1120	ATPase activity
SD37_RS37395	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_RS37400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD37_RS37405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD37_RS37420	COG0516	GMP reductase activity
SD37_RS37470	COG0459	protein refolding
SD37_RS37475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SD37_RS37485	COG1215	transferase activity, transferring glycosyl groups
SD37_RS37505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SD37_RS37510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SD37_RS37515	COG0456	acetyltransferase
SD37_RS37525	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS37530	COG0825	malonyl-CoA metabolic process
SD37_RS37530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SD37_RS37535	COG0802	atpase or kinase
SD37_RS37545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SD37_RS37550	COG3842	ATPase activity
SD37_RS37555	COG1070	Carbohydrate kinase
SD37_RS37570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SD37_RS37595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD37_RS37600	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS37625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD37_RS37635	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SD37_RS37665	COG0443	Heat shock 70 kDa protein
SD37_RS37670	COG1674	ftsk spoiiie
SD37_RS37680	COG1404	Belongs to the peptidase S8 family
SD37_RS37715	COG0101	tRNA pseudouridine synthase activity
SD37_RS37720	COG0203	ribosomal protein L17
SD37_RS37725	COG0202	RNA polymerase activity
SD37_RS37730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SD37_RS37735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SD37_RS37750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SD37_RS37755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SD37_RS37765	COG0563	adenylate kinase activity
SD37_RS37775	COG1280	lysine exporter protein (LysE YggA)
SD37_RS37790	COG1841	ribosomal large subunit assembly
SD37_RS37795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SD37_RS37800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SD37_RS37805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SD37_RS37810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SD37_RS37820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SD37_RS37825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SD37_RS37830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SD37_RS37835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SD37_RS37840	COG0255	Belongs to the universal ribosomal protein uL29 family
SD37_RS37850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SD37_RS37855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SD37_RS37860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SD37_RS37865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SD37_RS37870	COG0089	rRNA binding
SD37_RS37875	COG0088	Forms part of the polypeptide exit tunnel
SD37_RS37880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SD37_RS37885	COG0051	transcription antitermination factor activity, RNA binding
SD37_RS37895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SD37_RS37900	COG0049	tRNA binding
SD37_RS37905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SD37_RS37960	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SD37_RS37965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD37_RS37970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SD37_RS38000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SD37_RS38025	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SD37_RS38060	COG0081	regulation of translation
SD37_RS38085	COG0436	Aminotransferase
SD37_RS38090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS38095	COG2755	lipolytic protein G-D-S-L family
SD37_RS38105	COG2030	dehydratase
SD37_RS38110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SD37_RS38140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SD37_RS38150	COG0586	Pfam SNARE associated Golgi protein
SD37_RS38155	COG4585	Histidine kinase
SD37_RS38160	COG2197	response regulator
SD37_RS38165	COG0640	Transcriptional regulator
SD37_RS38170	COG0346	lactoylglutathione lyase activity
SD37_RS38280	COG1666	GTP binding
SD37_RS38300	COG0501	Belongs to the peptidase M48B family
SD37_RS38330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SD37_RS38345	COG4310	Domain of unknown function (DUF2172)
SD37_RS38355	COG1216	Glycosyl transferase, family 2
SD37_RS38355	COG0463	Glycosyl transferase, family 2
SD37_RS38370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SD37_RS38420	COG0367	asparagine synthase
SD37_RS38440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD37_RS38465	COG1834	amidinotransferase
SD37_RS38470	COG1522	sequence-specific DNA binding
SD37_RS38480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SD37_RS38480	COG0674	pyruvate-flavodoxin oxidoreductase activity
SD37_RS38485	COG1013	pyruvate-flavodoxin oxidoreductase activity
SD37_RS38495	COG0142	geranyltranstransferase activity
SD37_RS38525	COG1196	nuclear chromosome segregation
SD37_RS38560	COG1007	ATP synthesis coupled electron transport
SD37_RS38570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SD37_RS38575	COG0713	ATP synthesis coupled electron transport
SD37_RS38580	COG0839	Belongs to the complex I subunit 6 family
SD37_RS38585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD37_RS38590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SD37_RS38595	COG1034	ATP synthesis coupled electron transport
SD37_RS38610	COG0649	NAD binding
SD37_RS38615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD37_RS38620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SD37_RS38635	COG2226	methyltransferase
SD37_RS38645	COG0438	transferase activity, transferring glycosyl groups
SD37_RS38670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SD37_RS38675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SD37_RS38700	COG1522	sequence-specific DNA binding
SD37_RS38720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SD37_RS38730	COG0785	Cytochrome C biogenesis protein
SD37_RS38750	COG0406	alpha-ribazole phosphatase activity
SD37_RS38755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SD37_RS38760	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SD37_RS38800	COG1914	H( )-stimulated, divalent metal cation uptake system
SD37_RS38805	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS38815	COG1648	precorrin-2 dehydrogenase activity
SD37_RS38815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SD37_RS38820	COG0181	hydroxymethylbilane synthase activity
SD37_RS38825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SD37_RS38830	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SD37_RS38845	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS38850	COG1595	DNA-templated transcription, initiation
SD37_RS38880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SD37_RS38910	COG5002	protein histidine kinase activity
SD37_RS38925	COG0588	phosphoglycerate mutase activity
SD37_RS38940	COG0438	transferase activity, transferring glycosyl groups
SD37_RS38955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SD37_RS38985	COG2130	NADP-dependent
SD37_RS39010	COG2986	histidine ammonia-lyase
SD37_RS39040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SD37_RS39040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SD37_RS39060	COG2733	membrane
SD37_RS39080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD37_RS39085	COG2364	Membrane
SD37_RS39120	COG3226	Transcriptional regulator
SD37_RS39130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS39190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SD37_RS39205	COG2233	PERMEase
SD37_RS39270	COG1278	Cold shock
SD37_RS39285	COG1595	DNA-templated transcription, initiation
SD37_RS39305	COG0515	serine threonine protein kinase
SD37_RS39330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD37_RS39340	COG2197	response regulator
SD37_RS39365	COG4585	Histidine kinase
SD37_RS39370	COG2197	response regulator
SD37_RS39380	COG0028	Belongs to the TPP enzyme family
SD37_RS39395	COG1132	(ABC) transporter
SD37_RS39400	COG1132	(ABC) transporter
SD37_RS39405	COG0515	serine threonine protein kinase
SD37_RS39445	COG4585	Histidine kinase
SD37_RS39450	COG2197	response regulator
SD37_RS39480	COG1278	Cold shock
SD37_RS39550	COG1278	Cold shock
SD37_RS39560	COG0587	DNA-directed DNA polymerase activity
SD37_RS39575	COG3629	intracellular signal transduction
SD37_RS39575	COG3903	Transcriptional regulator
SD37_RS39650	COG0270	DNA (cytosine-5-)-methyltransferase activity
SD37_RS39705	COG1388	LysM domain
SD37_RS39705	COG0791	NLP P60 protein
SD37_RS39705	COG3103	Sh3 type 3 domain protein
SD37_RS39795	COG0714	Associated with various cellular activities
SD37_RS39930	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SD37_RS39940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SD37_RS39950	COG0463	Glycosyl transferase, family 2
SD37_RS39970	COG0438	transferase activity, transferring glycosyl groups
SD37_RS40015	COG0602	queuosine metabolic process
SD37_RS40065	COG2318	DinB family
SD37_RS40070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SD37_RS40105	COG1846	Transcriptional regulator
SD37_RS40120	COG0446	pyridine nucleotide-disulphide oxidoreductase
SD37_RS40120	COG1902	pentaerythritol trinitrate reductase activity
SD37_RS40125	COG0287	Prephenate dehydrogenase
SD37_RS40135	COG2175	clavaminate synthase activity
SD37_RS40175	COG0702	epimerase
SD37_RS40190	COG1131	(ABC) transporter
SD37_RS40195	COG3559	Exporter of polyketide antibiotics
SD37_RS40230	COG2172	sigma factor antagonist activity
SD37_RS40250	COG0667	Aldo Keto reductase
SD37_RS40280	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS40285	COG1309	transcriptional regulator
SD37_RS40325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SD37_RS40325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SD37_RS40330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD37_RS40355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SD37_RS40360	COG2826	transposase and inactivated derivatives, IS30 family
SD37_RS40375	COG2186	Transcriptional regulator
SD37_RS40380	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SD37_RS40400	COG1522	sequence-specific DNA binding
SD37_RS40420	COG1672	PFAM Archaeal ATPase
SD37_RS40420	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SD37_RS40465	COG0504	CTP synthase activity
SD37_RS40525	COG2234	aminopeptidase activity
SD37_RS40530	COG3321	synthase
SD37_RS40530	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS40530	COG0604	alcohol dehydrogenase
SD37_RS40545	COG0596	Alpha beta hydrolase
SD37_RS40575	COG1216	Glycosyl transferase, family 2
SD37_RS40605	COG1216	Glycosyl transferase, family 2
SD37_RS40615	COG0277	FAD linked oxidase domain protein
SD37_RS40620	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS40660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SD37_RS40665	COG0671	phosphoesterase, PA-phosphatase related
SD37_RS40680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD37_RS40685	COG0561	phosphatase activity
SD37_RS40730	COG0318	PFAM AMP-dependent synthetase and ligase
SD37_RS40735	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS40750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SD37_RS40790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SD37_RS40805	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SD37_RS40830	COG0477	Major facilitator Superfamily
SD37_RS40845	COG0579	oxidoreductase
SD37_RS40855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SD37_RS40860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SD37_RS40865	COG0596	Alpha beta hydrolase
SD37_RS40870	COG3766	membrane
SD37_RS40875	COG0754	glutathionylspermidine amidase activity
SD37_RS40910	COG0406	alpha-ribazole phosphatase activity
SD37_RS40920	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SD37_RS40925	COG1072	(Pantothenic acid kinase))
SD37_RS40950	COG4715	Zinc finger, swim domain protein
SD37_RS41005	COG4988	ABC transporter
SD37_RS41010	COG1294	oxidase, subunit
SD37_RS41015	COG1271	oxidase subunit
SD37_RS41080	COG2235	arginine
SD37_RS41095	COG1191	sigma factor activity
SD37_RS41135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_RS41145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD37_RS41170	COG3275	phosphorelay sensor kinase activity
SD37_RS41180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SD37_RS41240	COG0438	transferase activity, transferring glycosyl groups
SD37_RS41260	COG2197	response regulator
SD37_RS41265	COG4585	Histidine kinase
SD37_RS41280	COG0477	Major facilitator Superfamily
SD37_RS41295	COG0405	Gamma-glutamyltransferase
SD37_RS41315	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD37_RS41325	COG2226	methyltransferase
SD37_RS41350	COG1174	glycine betaine transport
SD37_RS41360	COG1174	glycine betaine transport
SD37_RS41375	COG2372	response to copper ion
SD37_RS41375	COG1276	copper resistance
SD37_RS41435	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SD37_RS41440	COG0702	epimerase
SD37_RS41460	COG2301	Belongs to the HpcH HpaI aldolase family
SD37_RS41485	COG1028	Short-chain dehydrogenase reductase Sdr
SD37_RS41490	COG1012	belongs to the aldehyde dehydrogenase family
SD37_RS41500	COG0444	Belongs to the ABC transporter superfamily
SD37_RS41505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD37_RS41515	COG0747	negative chemotaxis
SD37_RS41520	COG2186	Transcriptional regulator
SD37_RS41545	COG0626	cystathionine gamma-synthase activity
SD37_RS41550	COG0667	Aldo Keto reductase
SD37_RS41570	COG1716	ATPase activity
SD37_RS41575	COG1716	ATPase activity
SD37_RS41590	COG0768	penicillin binding
SD37_RS41595	COG0515	serine threonine protein kinase
SD37_RS41650	COG3764	Sortase (surface protein transpeptidase)
SD37_RS41670	COG0705	Rhomboid family
SD37_RS41670	COG0457	Tetratricopeptide repeat
SD37_RS41755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SD37_RS41760	COG0187	DNA topoisomerase II activity
SD37_RS41765	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SD37_RS41770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SD37_RS41775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SD37_RS41780	COG0592	DNA-directed DNA polymerase activity