locus-tag	class	description
AORI_RS40950	COG0592	DNA-directed DNA polymerase activity
AORI_RS40955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AORI_RS40960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AORI_RS40965	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AORI_RS40970	COG0187	DNA topoisomerase II activity
AORI_RS40975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AORI_RS41015	COG0789	Transcriptional regulator
AORI_RS41025	COG2197	response regulator
AORI_RS41090	COG0705	Rhomboid family
AORI_RS41090	COG0457	Tetratricopeptide repeat
AORI_RS41110	COG3764	Sortase (surface protein transpeptidase)
AORI_RS41175	COG0515	serine threonine protein kinase
AORI_RS41180	COG0768	penicillin binding
AORI_RS41195	COG1716	ATPase activity
AORI_RS41200	COG1716	ATPase activity
AORI_RS41220	COG0626	cystathionine gamma-synthase activity
AORI_RS41250	COG0747	negative chemotaxis
AORI_RS41260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AORI_RS41265	COG0444	Belongs to the ABC transporter superfamily
AORI_RS41275	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS41285	COG0154	amidase activity
AORI_RS41295	COG2301	Belongs to the HpcH HpaI aldolase family
AORI_RS41315	COG0702	epimerase
AORI_RS41320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AORI_RS41380	COG1276	copper resistance
AORI_RS41380	COG2372	response to copper ion
AORI_RS41395	COG1174	glycine betaine transport
AORI_RS41405	COG1174	glycine betaine transport
AORI_RS41430	COG2226	methyltransferase
AORI_RS41440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_RS41460	COG0405	Gamma-glutamyltransferase
AORI_RS41475	COG0477	Major facilitator Superfamily
AORI_RS41490	COG4585	Histidine kinase
AORI_RS41495	COG2197	response regulator
AORI_RS41515	COG0438	transferase activity, transferring glycosyl groups
AORI_RS41520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AORI_RS41595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AORI_RS41605	COG3275	phosphorelay sensor kinase activity
AORI_RS41630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_RS41640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_RS41680	COG1191	sigma factor activity
AORI_RS41695	COG2235	arginine
AORI_RS41760	COG1271	oxidase subunit
AORI_RS41765	COG1294	oxidase, subunit
AORI_RS41770	COG4988	ABC transporter
AORI_RS41830	COG4715	Zinc finger, swim domain protein
AORI_RS41840	COG1072	(Pantothenic acid kinase))
AORI_RS41845	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AORI_RS41855	COG0406	alpha-ribazole phosphatase activity
AORI_RS41890	COG0754	glutathionylspermidine amidase activity
AORI_RS41895	COG3766	membrane
AORI_RS41900	COG0596	Alpha beta hydrolase
AORI_RS41905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AORI_RS41910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AORI_RS41925	COG0579	oxidoreductase
AORI_RS41940	COG0477	Major facilitator Superfamily
AORI_RS41965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AORI_RS41975	COG0438	transferase activity, transferring glycosyl groups
AORI_RS41980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AORI_RS42020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AORI_RS42035	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS42040	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS42080	COG0561	phosphatase activity
AORI_RS42085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS42105	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AORI_RS42130	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS42135	COG0277	FAD linked oxidase domain protein
AORI_RS42145	COG1216	Glycosyl transferase, family 2
AORI_RS42180	COG1216	Glycosyl transferase, family 2
AORI_RS42210	COG2089	acid synthase
AORI_RS42215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AORI_RS42220	COG1086	Polysaccharide biosynthesis protein
AORI_RS42225	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AORI_RS42245	COG0596	Alpha beta hydrolase
AORI_RS42260	COG3321	synthase
AORI_RS42260	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS42260	COG0604	alcohol dehydrogenase
AORI_RS42265	COG2234	aminopeptidase activity
AORI_RS42280	COG4941	Belongs to the sigma-70 factor family
AORI_RS42285	COG3795	YCII-related domain
AORI_RS42340	COG0504	CTP synthase activity
AORI_RS42355	COG3209	COG3209 Rhs family protein
AORI_RS42385	COG1672	PFAM Archaeal ATPase
AORI_RS42385	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AORI_RS42400	COG1522	sequence-specific DNA binding
AORI_RS42405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AORI_RS42420	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AORI_RS42425	COG2186	Transcriptional regulator
AORI_RS42440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AORI_RS42465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_RS42470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AORI_RS42470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AORI_RS42515	COG1309	transcriptional regulator
AORI_RS42520	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS42565	COG2172	sigma factor antagonist activity
AORI_RS42600	COG3559	Exporter of polyketide antibiotics
AORI_RS42605	COG1131	(ABC) transporter
AORI_RS42620	COG0702	epimerase
AORI_RS42660	COG2175	clavaminate synthase activity
AORI_RS42670	COG0287	Prephenate dehydrogenase
AORI_RS42675	COG0446	pyridine nucleotide-disulphide oxidoreductase
AORI_RS42675	COG1902	pentaerythritol trinitrate reductase activity
AORI_RS42690	COG1846	Transcriptional regulator
AORI_RS42725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AORI_RS42730	COG2318	DinB family
AORI_RS42790	COG0402	S-adenosylhomocysteine deaminase activity
AORI_RS42810	COG1278	Cold shock
AORI_RS42820	COG2197	response regulator
AORI_RS42825	COG4585	Histidine kinase
AORI_RS42860	COG0515	serine threonine protein kinase
AORI_RS42865	COG1132	(ABC) transporter
AORI_RS42870	COG1132	(ABC) transporter
AORI_RS42885	COG0028	Belongs to the TPP enzyme family
AORI_RS42910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_RS42930	COG0515	serine threonine protein kinase
AORI_RS42965	COG1278	Cold shock
AORI_RS43025	COG2233	PERMEase
AORI_RS43040	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AORI_RS43105	COG3226	Transcriptional regulator
AORI_RS43140	COG2364	Membrane
AORI_RS43145	COG2186	Transcriptional regulator
AORI_RS43165	COG2733	membrane
AORI_RS43185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AORI_RS43190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AORI_RS43215	COG2986	histidine ammonia-lyase
AORI_RS43240	COG2130	NADP-dependent
AORI_RS43270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AORI_RS43280	COG2267	carboxylic ester hydrolase activity
AORI_RS43285	COG0438	transferase activity, transferring glycosyl groups
AORI_RS43300	COG0588	phosphoglycerate mutase activity
AORI_RS43315	COG5002	protein histidine kinase activity
AORI_RS43345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AORI_RS43375	COG1595	DNA-templated transcription, initiation
AORI_RS43395	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AORI_RS43400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AORI_RS43405	COG0181	hydroxymethylbilane synthase activity
AORI_RS43410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AORI_RS43410	COG1648	precorrin-2 dehydrogenase activity
AORI_RS43420	COG1914	H( )-stimulated, divalent metal cation uptake system
AORI_RS43450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AORI_RS43455	COG0406	alpha-ribazole phosphatase activity
AORI_RS43465	COG0785	Cytochrome C biogenesis protein
AORI_RS43475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AORI_RS43495	COG1522	sequence-specific DNA binding
AORI_RS43525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AORI_RS43530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AORI_RS43555	COG0438	transferase activity, transferring glycosyl groups
AORI_RS43565	COG2226	methyltransferase
AORI_RS43580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AORI_RS43585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AORI_RS43590	COG0649	NAD binding
AORI_RS43605	COG1034	ATP synthesis coupled electron transport
AORI_RS43610	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AORI_RS43615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AORI_RS43620	COG0839	Belongs to the complex I subunit 6 family
AORI_RS43625	COG0713	ATP synthesis coupled electron transport
AORI_RS43630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AORI_RS43640	COG1007	ATP synthesis coupled electron transport
AORI_RS43680	COG1196	nuclear chromosome segregation
AORI_RS43705	COG0142	geranyltranstransferase activity
AORI_RS43715	COG1013	pyruvate-flavodoxin oxidoreductase activity
AORI_RS43720	COG0674	pyruvate-flavodoxin oxidoreductase activity
AORI_RS43720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AORI_RS43730	COG1522	sequence-specific DNA binding
AORI_RS43735	COG1834	amidinotransferase
AORI_RS43755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_RS43775	COG0367	asparagine synthase
AORI_RS43830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AORI_RS43845	COG1215	transferase activity, transferring glycosyl groups
AORI_RS43855	COG4310	Domain of unknown function (DUF2172)
AORI_RS43870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AORI_RS43900	COG0501	Belongs to the peptidase M48B family
AORI_RS43910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS43930	COG1666	GTP binding
AORI_RS43960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AORI_RS43990	COG0346	lactoylglutathione lyase activity
AORI_RS43995	COG0640	Transcriptional regulator
AORI_RS44000	COG2197	response regulator
AORI_RS44005	COG4585	Histidine kinase
AORI_RS44010	COG0586	Pfam SNARE associated Golgi protein
AORI_RS44025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AORI_RS44055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AORI_RS44060	COG2030	dehydratase
AORI_RS44080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS44085	COG0436	Aminotransferase
AORI_RS44110	COG0081	regulation of translation
AORI_RS44130	COG0222	ribosome binding
AORI_RS44145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_RS44170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AORI_RS44200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AORI_RS44205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_RS44260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AORI_RS44265	COG0049	tRNA binding
AORI_RS44270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AORI_RS44280	COG0051	transcription antitermination factor activity, RNA binding
AORI_RS44285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AORI_RS44290	COG0088	Forms part of the polypeptide exit tunnel
AORI_RS44295	COG0089	rRNA binding
AORI_RS44300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AORI_RS44305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AORI_RS44310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AORI_RS44315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AORI_RS44325	COG0255	Belongs to the universal ribosomal protein uL29 family
AORI_RS44330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AORI_RS44335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AORI_RS44340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AORI_RS44345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AORI_RS44355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AORI_RS44360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AORI_RS44365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AORI_RS44370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AORI_RS44375	COG1841	ribosomal large subunit assembly
AORI_RS44400	COG0563	adenylate kinase activity
AORI_RS44410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AORI_RS44415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AORI_RS44430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AORI_RS44435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AORI_RS44440	COG0202	RNA polymerase activity
AORI_RS44445	COG0203	ribosomal protein L17
AORI_RS44450	COG0101	tRNA pseudouridine synthase activity
AORI_RS44485	COG1404	Belongs to the peptidase S8 family
AORI_RS44495	COG1674	ftsk spoiiie
AORI_RS44500	COG0443	Heat shock 70 kDa protein
AORI_RS44530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AORI_RS44535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AORI_RS44540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AORI_RS44570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AORI_RS44595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AORI_RS44605	COG1349	DNA-binding transcription factor activity
AORI_RS44610	COG1070	Carbohydrate kinase
AORI_RS44615	COG3842	ATPase activity
AORI_RS44620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AORI_RS44630	COG0802	atpase or kinase
AORI_RS44635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AORI_RS44635	COG0825	malonyl-CoA metabolic process
AORI_RS44640	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS44650	COG0456	acetyltransferase
AORI_RS44655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AORI_RS44660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AORI_RS44680	COG1215	transferase activity, transferring glycosyl groups
AORI_RS44690	COG0546	phosphoglycolate phosphatase activity
AORI_RS44750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AORI_RS44755	COG0459	protein refolding
AORI_RS44805	COG0516	GMP reductase activity
AORI_RS44810	COG2318	DinB family
AORI_RS44825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AORI_RS44830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS44835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS44840	COG1120	ATPase activity
AORI_RS44845	COG0277	FAD linked oxidase domain protein
AORI_RS44850	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS44865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AORI_RS44865	COG0519	Catalyzes the synthesis of GMP from XMP
AORI_RS44900	COG0697	spore germination
AORI_RS44905	COG0583	DNA-binding transcription factor activity
AORI_RS44915	COG0515	serine threonine protein kinase
AORI_RS44920	COG0515	serine threonine protein kinase
AORI_RS44955	COG0739	heme binding
AORI_RS44970	COG0045	succinate-CoA ligase (ADP-forming) activity
AORI_RS44995	COG0138	bifunctional purine biosynthesis protein purh
AORI_RS45040	COG1073	alpha beta
AORI_RS45090	COG2814	Major facilitator Superfamily
AORI_RS45095	COG0640	Transcriptional regulator
AORI_RS45100	COG2814	Major facilitator Superfamily
AORI_RS45145	COG0667	Aldo Keto reductase
AORI_RS45165	COG2264	protein methyltransferase activity
AORI_RS45190	COG1234	tRNA 3'-trailer cleavage
AORI_RS45235	COG0180	Tryptophanyl-tRNA synthetase
AORI_RS45240	COG1295	ribonuclease BN
AORI_RS45245	COG1686	Belongs to the peptidase S11 family
AORI_RS45255	COG1404	Belongs to the peptidase S8 family
AORI_RS45275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AORI_RS45290	COG2009	succinate dehydrogenase
AORI_RS45295	COG1744	ABC transporter substrate-binding protein PnrA-like
AORI_RS45300	COG3845	ABC transporter
AORI_RS45310	COG1079	Belongs to the binding-protein-dependent transport system permease family
AORI_RS45330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AORI_RS45335	COG2271	Major facilitator Superfamily
AORI_RS45365	COG1733	regulation of RNA biosynthetic process
AORI_RS45375	COG1063	alcohol dehydrogenase
AORI_RS45390	COG0395	ABC-type sugar transport system, permease component
AORI_RS45410	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS45415	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS45420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AORI_RS45425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_RS45465	COG0667	Aldo Keto reductase
AORI_RS45470	COG0667	Aldo Keto reductase
AORI_RS45510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AORI_RS45540	COG0515	serine threonine protein kinase
AORI_RS45565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_RS45565	COG1473	amidohydrolase
AORI_RS45605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AORI_RS45610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AORI_RS45615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AORI_RS45640	COG4770	biotin carboxylase activity
AORI_RS45655	COG1301	dicarboxylic acid transport
AORI_RS45660	COG0424	maF-like protein
AORI_RS45665	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_RS45700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_RS45705	COG2197	response regulator
AORI_RS45710	COG4585	Histidine kinase
AORI_RS45735	COG0640	Transcriptional regulator
AORI_RS45780	COG3103	Sh3 type 3 domain protein
AORI_RS45780	COG1388	LysM domain
AORI_RS45780	COG0791	NLP P60 protein
AORI_RS45815	COG0483	inositol monophosphate 1-phosphatase activity
AORI_RS45825	COG2205	protein histidine kinase activity
AORI_RS45840	COG2197	response regulator
AORI_RS45845	COG2197	response regulator
AORI_RS45855	COG0477	Major facilitator Superfamily
AORI_RS45900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AORI_RS45915	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS45935	COG2259	Doxx family
AORI_RS45945	COG1316	TRANSCRIPTIONal
AORI_RS45950	COG1316	TRANSCRIPTIONal
AORI_RS45980	COG0438	transferase activity, transferring glycosyl groups
AORI_RS46000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_RS46025	COG1725	Transcriptional regulator
AORI_RS46045	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AORI_RS46045	COG0778	Nitroreductase
AORI_RS46050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AORI_RS46090	COG2171	N-acyltransferase activity
AORI_RS46100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_RS46145	COG1611	Belongs to the LOG family
AORI_RS46160	COG0463	Glycosyl transferase, family 2
AORI_RS46165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AORI_RS46170	COG4988	ABC transporter
AORI_RS46175	COG1294	oxidase, subunit
AORI_RS46180	COG1271	oxidase subunit
AORI_RS46215	COG0519	Catalyzes the synthesis of GMP from XMP
AORI_RS46225	COG1024	Enoyl-CoA hydratase
AORI_RS46230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AORI_RS46235	COG0671	phosphoesterase, PA-phosphatase related
AORI_RS46240	COG0583	DNA-binding transcription factor activity
AORI_RS46245	COG2814	Major facilitator Superfamily
AORI_RS46250	COG1595	DNA-templated transcription, initiation
AORI_RS46265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AORI_RS46270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AORI_RS46285	COG2239	Acts as a magnesium transporter
AORI_RS46295	COG0330	HflC and HflK could
AORI_RS46315	COG1960	acyl-CoA dehydrogenase activity
AORI_RS46360	COG1309	transcriptional regulator
AORI_RS46380	COG0598	Magnesium transport protein CorA
AORI_RS46405	COG0613	PHP domain protein
AORI_RS46410	COG2095	MarC family integral membrane protein
AORI_RS46435	COG0513	Belongs to the DEAD box helicase family
AORI_RS46470	COG2267	carboxylic ester hydrolase activity
AORI_RS46485	COG0402	S-adenosylhomocysteine deaminase activity
AORI_RS46495	COG0596	Alpha beta hydrolase
AORI_RS46525	COG1136	(ABC) transporter
AORI_RS46535	COG0243	molybdopterin cofactor binding
AORI_RS46540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_RS46545	COG2223	nitrite transmembrane transporter activity
AORI_RS46550	COG2146	nitrite reductase [NAD(P)H] activity
AORI_RS46550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_RS46555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_RS46555	COG2146	nitrite reductase [NAD(P)H] activity
AORI_RS46560	COG0745	RESPONSE REGULATOR receiver
AORI_RS46580	COG2378	regulation of single-species biofilm formation
AORI_RS46590	COG4585	Histidine kinase
AORI_RS46605	COG0210	DNA helicase
AORI_RS46650	COG0714	Associated with various cellular activities
AORI_RS46655	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AORI_RS46705	COG0612	Peptidase, M16
AORI_RS46720	COG1309	transcriptional regulator
AORI_RS46740	COG1175	transmembrane transport
AORI_RS46745	COG0395	ABC-type sugar transport system, permease component
AORI_RS46750	COG1486	melibiose metabolic process
AORI_RS46765	COG0640	Transcriptional regulator
AORI_RS46775	COG3265	gluconokinase activity
AORI_RS46785	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AORI_RS46800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AORI_RS46815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AORI_RS46840	COG2197	response regulator
AORI_RS46945	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AORI_RS46950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AORI_RS46955	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS46980	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS46985	COG3842	ATPase activity
AORI_RS46990	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AORI_RS46995	COG1176	ABC-type spermidine putrescine transport system, permease component I
AORI_RS47000	COG1177	transmembrane transport
AORI_RS47005	COG5479	isomerase activity
AORI_RS47005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AORI_RS47010	COG0596	Alpha beta hydrolase
AORI_RS47020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AORI_RS47025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AORI_RS47025	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AORI_RS47030	COG2318	DinB family
AORI_RS47045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AORI_RS47045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AORI_RS47050	COG0653	protein targeting
AORI_RS47075	COG0174	glutamine synthetase
AORI_RS47080	COG0154	amidase activity
AORI_RS47100	COG1522	sequence-specific DNA binding
AORI_RS47110	COG0505	Belongs to the CarA family
AORI_RS47120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AORI_RS47130	COG0174	glutamine synthetase
AORI_RS47185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AORI_RS47205	COG3480	Lon protease (S16) C-terminal proteolytic domain
AORI_RS47215	COG1615	UPF0182 protein
AORI_RS47245	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AORI_RS47250	COG2884	Cell division ATP-binding protein ftsE
AORI_RS47255	COG2177	Part of the ABC transporter FtsEX involved in
AORI_RS47260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AORI_RS47280	COG2197	response regulator
AORI_RS47285	COG4585	Histidine kinase
AORI_RS47305	COG0596	Alpha beta hydrolase
AORI_RS47320	COG2986	histidine ammonia-lyase
AORI_RS47325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AORI_RS47335	COG0402	S-adenosylhomocysteine deaminase activity
AORI_RS47340	COG1228	amidohydrolase
AORI_RS47355	COG4585	Histidine kinase
AORI_RS47360	COG2197	response regulator
AORI_RS47395	COG1643	Atp-dependent helicase
AORI_RS47400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_RS47415	COG0583	DNA-binding transcription factor activity
AORI_RS47425	COG0473	3-isopropylmalate dehydrogenase activity
AORI_RS47425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AORI_RS47435	COG0183	Belongs to the thiolase family
AORI_RS47445	COG2030	dehydratase
AORI_RS47450	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS47455	COG1960	acyl-CoA dehydrogenase activity
AORI_RS47460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AORI_RS47465	COG0187	DNA topoisomerase II activity
AORI_RS47480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS47490	COG3795	YCII-related domain
AORI_RS47505	COG0667	Aldo Keto reductase
AORI_RS47545	COG1793	dna ligase
AORI_RS47545	COG3285	dna ligase
AORI_RS47585	COG1942	4-Oxalocrotonate Tautomerase
AORI_RS47605	COG0438	transferase activity, transferring glycosyl groups
AORI_RS47625	COG0483	inositol monophosphate 1-phosphatase activity
AORI_RS47630	COG0438	transferase activity, transferring glycosyl groups
AORI_RS47645	COG2084	Dehydrogenase
AORI_RS47650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS47660	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_RS47665	COG0395	ABC-type sugar transport system, permease component
AORI_RS47670	COG1175	transmembrane transport
AORI_RS47675	COG2182	Extracellular solute-binding protein
AORI_RS47695	COG1309	transcriptional regulator
AORI_RS47725	COG0596	Alpha beta hydrolase
AORI_RS47740	COG3835	regulator
AORI_RS47760	COG0326	Molecular chaperone. Has ATPase activity
AORI_RS47775	COG1120	ATPase activity
AORI_RS47780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AORI_RS47785	COG1121	(ABC) transporter
AORI_RS47795	COG0247	lactate metabolic process
AORI_RS47795	COG2181	nitrate reductase activity
AORI_RS47815	COG2255	four-way junction helicase activity
AORI_RS47820	COG1403	HNH endonuclease
AORI_RS47895	COG3290	protein histidine kinase activity
AORI_RS47900	COG4565	transcriptional regulatory protein
AORI_RS47910	COG0477	Major facilitator Superfamily
AORI_RS47915	COG1940	carbohydrate kinase activity
AORI_RS47925	COG1129	ABC transporter
AORI_RS47930	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_RS47940	COG0673	inositol 2-dehydrogenase activity
AORI_RS47950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AORI_RS47960	COG0084	hydrolase, TatD family'
AORI_RS47975	COG3291	Pkd domain containing protein
AORI_RS48020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AORI_RS48025	COG4977	sequence-specific DNA binding
AORI_RS48075	COG1131	(ABC) transporter
AORI_RS48085	COG5650	phosphatidylinositol metabolic process
AORI_RS48090	COG2207	Transcriptional regulator
AORI_RS48120	COG2814	Major facilitator Superfamily
AORI_RS48125	COG4552	Acetyltransferase involved in intracellular survival and related
AORI_RS48130	COG1132	(ABC) transporter
AORI_RS48135	COG2375	cellular response to nickel ion
AORI_RS48135	COG1132	(ABC) transporter
AORI_RS48180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_RS48190	COG3511	phospholipase C
AORI_RS48200	COG0697	spore germination
AORI_RS48240	COG0300	oxidoreductase activity
AORI_RS48290	COG3387	PFAM Glycoside hydrolase 15-related
AORI_RS48305	COG2909	trisaccharide binding
AORI_RS48335	COG0628	permease
AORI_RS48365	COG1181	Belongs to the D-alanine--D-alanine ligase family
AORI_RS48370	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AORI_RS48390	COG1132	(ABC) transporter
AORI_RS48415	COG2124	cytochrome p450
AORI_RS48420	COG2124	cytochrome p450
AORI_RS48425	COG2124	cytochrome p450
AORI_RS48435	COG1819	glycosyl
AORI_RS48440	COG1819	glycosyl
AORI_RS48490	COG0475	glutathione-regulated potassium exporter activity
AORI_RS48515	COG3424	synthase
AORI_RS48520	COG1024	Enoyl-CoA hydratase
AORI_RS48525	COG1024	Enoyl-CoA hydratase
AORI_RS48530	COG1024	Enoyl-CoA hydratase
AORI_RS48535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AORI_RS48545	COG0667	Aldo Keto reductase
AORI_RS48625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AORI_RS48630	COG1660	Displays ATPase and GTPase activities
AORI_RS48660	COG1937	Protein conserved in bacteria
AORI_RS48665	COG1937	Protein conserved in bacteria
AORI_RS48705	COG2197	response regulator
AORI_RS48720	COG2124	cytochrome p450
AORI_RS48750	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_RS48750	COG2319	Wd-40 repeat
AORI_RS48785	COG0142	geranyltranstransferase activity
AORI_RS48790	COG0789	Transcriptional regulator
AORI_RS48820	COG0179	Fumarylacetoacetate (FAA) hydrolase
AORI_RS48825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_RS48870	COG2304	oxidoreductase activity
AORI_RS48895	COG2226	methyltransferase
AORI_RS49015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_RS49020	COG0765	amino acid transport
AORI_RS49045	COG1131	(ABC) transporter
AORI_RS49110	COG4991	sh3 domain protein
AORI_RS49115	COG3903	Transcriptional regulator
AORI_RS49115	COG3629	intracellular signal transduction
AORI_RS49120	COG4991	sh3 domain protein
AORI_RS49125	COG3540	Alkaline phosphatase
AORI_RS49135	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AORI_RS49140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AORI_RS49160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AORI_RS49170	COG0513	Belongs to the DEAD box helicase family
AORI_RS49185	COG2183	response to ionizing radiation
AORI_RS49200	COG2072	flavoprotein involved in K transport
AORI_RS49225	COG1309	transcriptional regulator
AORI_RS49240	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS49240	COG2030	dehydratase
AORI_RS49245	COG3396	Phenylacetate-CoA oxygenase
AORI_RS49250	COG3460	Phenylacetate-CoA oxygenase
AORI_RS49255	COG3396	Phenylacetate-CoA oxygenase
AORI_RS49260	COG2151	metal-sulfur cluster biosynthetic enzyme
AORI_RS49265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AORI_RS49270	COG0488	(ABC) transporter
AORI_RS49275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AORI_RS49275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AORI_RS49290	COG5002	protein histidine kinase activity
AORI_RS49300	COG1929	Belongs to the glycerate kinase type-1 family
AORI_RS49315	COG0542	response to heat
AORI_RS49320	COG1476	TRANSCRIPTIONal
AORI_RS49330	COG1131	(ABC) transporter
AORI_RS49335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_RS49350	COG2197	response regulator
AORI_RS49355	COG2319	Wd-40 repeat
AORI_RS49355	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_RS49360	COG3973	AAA domain
AORI_RS49400	COG1797	cobyrinic acid a,c-diamide synthase activity
AORI_RS49415	COG0789	Transcriptional regulator
AORI_RS49425	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AORI_RS49430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AORI_RS49440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AORI_RS49445	COG1492	cobalamin metabolic process
AORI_RS49460	COG1131	(ABC) transporter
AORI_RS49470	COG4585	Histidine kinase
AORI_RS49475	COG2197	response regulator
AORI_RS49500	COG0070	glutamate synthase
AORI_RS49500	COG0067	glutamate synthase
AORI_RS49500	COG0069	glutamate synthase activity
AORI_RS49505	COG1739	Uncharacterized protein family UPF0029
AORI_RS49520	COG1522	sequence-specific DNA binding
AORI_RS49535	COG0559	Belongs to the binding-protein-dependent transport system permease family
AORI_RS49540	COG0559	Belongs to the binding-protein-dependent transport system permease family
AORI_RS49555	COG2197	response regulator
AORI_RS49565	COG0247	lactate metabolic process
AORI_RS49565	COG0277	FAD linked oxidase domain protein
AORI_RS49590	COG1309	transcriptional regulator
AORI_RS49605	COG4552	Acetyltransferase involved in intracellular survival and related
AORI_RS49610	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AORI_RS49610	COG0235	Class ii aldolase
AORI_RS49625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AORI_RS49635	COG0010	Belongs to the arginase family
AORI_RS49640	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AORI_RS49645	COG3706	GGDEF domain
AORI_RS49665	COG1802	Transcriptional regulator
AORI_RS49675	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AORI_RS49710	COG0475	glutathione-regulated potassium exporter activity
AORI_RS49720	COG1643	Atp-dependent helicase
AORI_RS49730	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS49780	COG1024	Enoyl-CoA hydratase
AORI_RS49855	COG2205	protein histidine kinase activity
AORI_RS49855	COG2972	Histidine kinase
AORI_RS49860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AORI_RS49865	COG1136	(ABC) transporter
AORI_RS49875	COG0745	RESPONSE REGULATOR receiver
AORI_RS49880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AORI_RS49895	COG1609	Transcriptional regulator
AORI_RS49950	COG0596	Alpha beta hydrolase
AORI_RS49985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AORI_RS49990	COG0581	inorganic phosphate transmembrane transporter activity
AORI_RS50025	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS50070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AORI_RS50080	COG4221	oxidoreductase activity
AORI_RS50085	COG2267	carboxylic ester hydrolase activity
AORI_RS50120	COG1937	Protein conserved in bacteria
AORI_RS50125	COG3795	YCII-related domain
AORI_RS50150	COG1733	regulation of RNA biosynthetic process
AORI_RS50155	COG3629	intracellular signal transduction
AORI_RS50170	COG1917	Cupin 2, conserved barrel domain protein
AORI_RS50170	COG4977	sequence-specific DNA binding
AORI_RS50190	COG2124	cytochrome p450
AORI_RS50225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_RS50245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_RS50265	COG2197	response regulator
AORI_RS50275	COG0009	L-threonylcarbamoyladenylate synthase
AORI_RS50280	COG1733	regulation of RNA biosynthetic process
AORI_RS50290	COG2197	response regulator
AORI_RS50300	COG1917	Cupin 2, conserved barrel domain protein
AORI_RS50300	COG4977	sequence-specific DNA binding
AORI_RS50305	COG2197	response regulator
AORI_RS50310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_RS50340	COG1595	DNA-templated transcription, initiation
AORI_RS50350	COG3285	dna ligase
AORI_RS50350	COG1793	dna ligase
AORI_RS50355	COG3285	dna ligase
AORI_RS50355	COG1793	dna ligase
AORI_RS50365	COG1846	Transcriptional regulator
AORI_RS50375	COG1113	amino acid transport
AORI_RS50385	COG1733	regulation of RNA biosynthetic process
AORI_RS50400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AORI_RS50440	COG0765	amino acid transport
AORI_RS50445	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AORI_RS50455	COG0540	Belongs to the ATCase OTCase family
AORI_RS50470	COG0436	Aminotransferase
AORI_RS50480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AORI_RS50485	COG2022	thiamine diphosphate biosynthetic process
AORI_RS50515	COG1609	Transcriptional regulator
AORI_RS50560	COG2902	Dehydrogenase
AORI_RS50590	COG0366	Alpha amylase catalytic
AORI_RS50600	COG0668	transmembrane transport
AORI_RS50620	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AORI_RS50630	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AORI_RS50645	COG0698	ribose 5-phosphate isomerase
AORI_RS50670	COG4941	Belongs to the sigma-70 factor family
AORI_RS50720	COG0784	Response regulator, receiver
AORI_RS50720	COG5002	protein histidine kinase activity
AORI_RS50735	COG0693	protein deglycase activity
AORI_RS50745	COG2815	serine threonine protein kinase
AORI_RS50745	COG0515	serine threonine protein kinase
AORI_RS50770	COG2814	Major facilitator Superfamily
AORI_RS50775	COG1846	Transcriptional regulator
AORI_RS50805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_RS50810	COG1215	transferase activity, transferring glycosyl groups
AORI_RS50815	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_RS50820	COG2205	protein histidine kinase activity
AORI_RS50825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AORI_RS50830	COG0544	peptidyl-prolyl cis-trans isomerase activity
AORI_RS50840	COG0740	serine-type endopeptidase activity
AORI_RS50845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AORI_RS50865	COG1309	transcriptional regulator
AORI_RS50875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AORI_RS50885	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS50890	COG1316	TRANSCRIPTIONal
AORI_RS50915	COG0525	valine-tRNA ligase activity
AORI_RS50930	COG0285	dihydrofolate synthase activity
AORI_RS50940	COG1403	HNH endonuclease
AORI_RS50955	COG1733	regulation of RNA biosynthetic process
AORI_RS50960	COG0105	UTP biosynthetic process
AORI_RS50980	COG1131	(ABC) transporter
AORI_RS50990	COG0842	Transport permease protein
AORI_RS51000	COG1530	ribonuclease E activity
AORI_RS51005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AORI_RS51010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AORI_RS51015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AORI_RS51045	COG0018	arginyl-trna synthetase
AORI_RS51050	COG0477	Major facilitator Superfamily
AORI_RS51060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AORI_RS51065	COG0799	negative regulation of ribosome biogenesis
AORI_RS51070	COG0406	alpha-ribazole phosphatase activity
AORI_RS51080	COG1307	EDD domain protein, DegV family
AORI_RS51085	COG1555	photosystem II stabilization
AORI_RS51090	COG0658	competence protein
AORI_RS51090	COG2333	competence protein COMEC
AORI_RS51105	COG0268	Binds directly to 16S ribosomal RNA
AORI_RS51120	COG2226	methyltransferase
AORI_RS51125	COG0481	GTPase activity
AORI_RS51140	COG2070	2-Nitropropane dioxygenase
AORI_RS51145	COG0531	amino acid
AORI_RS51155	COG0604	alcohol dehydrogenase
AORI_RS51170	COG2732	(Barnase) inhibitor
AORI_RS51240	COG2192	nodulation
AORI_RS51250	COG0463	Glycosyl transferase, family 2
AORI_RS51300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_RS51310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AORI_RS51320	COG1953	Uracil, thiamine, allantoin
AORI_RS51325	COG0745	RESPONSE REGULATOR receiver
AORI_RS51330	COG2205	protein histidine kinase activity
AORI_RS51365	COG1420	regulation of RNA biosynthetic process
AORI_RS51370	COG0484	heat shock protein binding
AORI_RS51380	COG0537	adenosine 5'-monophosphoramidase activity
AORI_RS51390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AORI_RS51405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AORI_RS51440	COG1381	Involved in DNA repair and RecF pathway recombination
AORI_RS51445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AORI_RS51455	COG0701	Predicted permease
AORI_RS51490	COG0423	glycine-tRNA ligase activity
AORI_RS51495	COG1131	(ABC) transporter
AORI_RS51505	COG4585	Histidine kinase
AORI_RS51510	COG2197	response regulator
AORI_RS51520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AORI_RS51535	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS51540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_RS51545	COG1595	DNA-templated transcription, initiation
AORI_RS51560	COG4106	trans-aconitate 2-methyltransferase activity
AORI_RS51600	COG1733	regulation of RNA biosynthetic process
AORI_RS51640	COG0702	epimerase
AORI_RS51655	COG3629	intracellular signal transduction
AORI_RS51655	COG3903	Transcriptional regulator
AORI_RS51675	COG0531	amino acid
AORI_RS51680	COG3647	Membrane
AORI_RS51695	COG2508	Transcriptional regulator
AORI_RS51700	COG2072	flavoprotein involved in K transport
AORI_RS51740	COG3903	Transcriptional regulator
AORI_RS51740	COG3629	intracellular signal transduction
AORI_RS51745	COG2223	nitrite transmembrane transporter activity
AORI_RS51750	COG2207	Transcriptional regulator
AORI_RS51770	COG0137	argininosuccinate synthase activity
AORI_RS51825	COG0702	epimerase
AORI_RS51835	COG5002	protein histidine kinase activity
AORI_RS51835	COG3850	Histidine kinase
AORI_RS51885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS51955	COG1316	TRANSCRIPTIONal
AORI_RS51970	COG1960	acyl-CoA dehydrogenase activity
AORI_RS51975	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_RS51985	COG1024	Enoyl-CoA hydratase
AORI_RS51990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AORI_RS51995	COG0583	DNA-binding transcription factor activity
AORI_RS52000	COG5002	protein histidine kinase activity
AORI_RS52005	COG0745	RESPONSE REGULATOR receiver
AORI_RS52015	COG2936	dipeptidyl-peptidase activity
AORI_RS52030	COG1733	regulation of RNA biosynthetic process
AORI_RS52070	COG0779	Required for maturation of 30S ribosomal subunits
AORI_RS52095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AORI_RS52115	COG0201	protein transport
AORI_RS52125	COG3629	intracellular signal transduction
AORI_RS52125	COG3903	Transcriptional regulator
AORI_RS52145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AORI_RS52165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AORI_RS52170	COG1185	polyribonucleotide nucleotidyltransferase activity
AORI_RS52180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AORI_RS52200	COG3214	Protein conserved in bacteria
AORI_RS52225	COG0515	serine threonine protein kinase
AORI_RS52230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_RS52235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AORI_RS52245	COG1113	amino acid transport
AORI_RS52275	COG0655	NAD(P)H dehydrogenase (quinone) activity
AORI_RS52285	COG1674	ftsk spoiiie
AORI_RS52300	COG0596	Alpha beta hydrolase
AORI_RS52310	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AORI_RS52315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AORI_RS52325	COG1058	Belongs to the CinA family
AORI_RS52325	COG1546	Belongs to the CinA family
AORI_RS52330	COG1396	sequence-specific DNA binding
AORI_RS52340	COG1842	Phage shock protein A
AORI_RS52350	COG0154	amidase activity
AORI_RS52355	COG0167	dihydroorotate dehydrogenase activity
AORI_RS52365	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AORI_RS52370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AORI_RS52375	COG1192	Involved in chromosome partitioning
AORI_RS52385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AORI_RS52395	COG1305	Transglutaminase-like
AORI_RS52405	COG0714	Associated with various cellular activities
AORI_RS52435	COG2001	Belongs to the MraZ family
AORI_RS52440	COG0275	rRNA processing
AORI_RS52450	COG0768	penicillin binding
AORI_RS52465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AORI_RS52470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AORI_RS52480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AORI_RS52485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AORI_RS52490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AORI_RS52500	COG0702	epimerase
AORI_RS52545	COG0142	geranyltranstransferase activity
AORI_RS52615	COG0242	peptide deformylase activity
AORI_RS52620	COG1201	RNA secondary structure unwinding
AORI_RS52625	COG0443	Heat shock 70 kDa protein
AORI_RS52635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AORI_RS52640	COG2137	regulation of response to DNA damage stimulus
AORI_RS52660	COG0800	Aldolase
AORI_RS52680	COG1053	succinate dehydrogenase
AORI_RS52695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_RS52700	COG0765	amino acid transport
AORI_RS52705	COG0765	amino acid transport
AORI_RS52710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_RS52715	COG1126	abc transporter atp-binding protein
AORI_RS52720	COG0745	RESPONSE REGULATOR receiver
AORI_RS52725	COG2205	protein histidine kinase activity
AORI_RS52735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AORI_RS52750	COG1196	nuclear chromosome segregation
AORI_RS52760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AORI_RS52780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AORI_RS52790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AORI_RS52800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AORI_RS52805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AORI_RS52840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AORI_RS52850	COG1505	serine-type exopeptidase activity
AORI_RS52875	COG2936	dipeptidyl-peptidase activity
AORI_RS52895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AORI_RS52910	COG0123	including yeast histone deacetylase and acetoin utilization protein
AORI_RS52925	COG1309	transcriptional regulator
AORI_RS52935	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS52940	COG1960	acyl-CoA dehydrogenase activity
AORI_RS52945	COG1960	acyl-CoA dehydrogenase activity
AORI_RS52955	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS52965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_RS52970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_RS53020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS53060	COG0003	Pfam Anion-transporting ATPase
AORI_RS53070	COG1940	carbohydrate kinase activity
AORI_RS53080	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_RS53105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AORI_RS53115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AORI_RS53135	COG0640	Transcriptional regulator
AORI_RS53155	COG1946	Acyl-CoA thioesterase
AORI_RS53175	COG1672	PFAM Archaeal ATPase
AORI_RS53175	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AORI_RS53180	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS53200	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AORI_RS53215	COG1024	Enoyl-CoA hydratase
AORI_RS53230	COG1566	PFAM secretion protein HlyD family protein
AORI_RS53235	COG2814	Major facilitator Superfamily
AORI_RS53250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_RS53265	COG2018	Roadblock/LC7 domain
AORI_RS53295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AORI_RS53295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AORI_RS53295	COG1703	isobutyryl-CoA mutase activity
AORI_RS53305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS53310	COG1309	transcriptional regulator
AORI_RS53315	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AORI_RS53330	COG0657	acetylesterase activity
AORI_RS53340	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53345	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53360	COG0183	Belongs to the thiolase family
AORI_RS53370	COG0196	riboflavin kinase activity
AORI_RS53380	COG2030	dehydratase
AORI_RS53400	COG1053	succinate dehydrogenase
AORI_RS53410	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53415	COG2267	carboxylic ester hydrolase activity
AORI_RS53420	COG0346	lactoylglutathione lyase activity
AORI_RS53425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AORI_RS53465	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53470	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53475	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53480	COG1024	Enoyl-CoA hydratase
AORI_RS53485	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS53490	COG1960	acyl-CoA dehydrogenase activity
AORI_RS53495	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS53500	COG1309	transcriptional regulator
AORI_RS53505	COG0183	Belongs to the thiolase family
AORI_RS53510	COG2814	Major facilitator Superfamily
AORI_RS53520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AORI_RS53560	COG0110	maltose O-acetyltransferase activity
AORI_RS53575	COG0596	Alpha beta hydrolase
AORI_RS53595	COG1024	Enoyl-CoA hydratase
AORI_RS53605	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS53625	COG0183	Belongs to the thiolase family
AORI_RS53630	COG2124	cytochrome p450
AORI_RS53640	COG1295	ribonuclease BN
AORI_RS53675	COG2070	2-Nitropropane dioxygenase
AORI_RS53685	COG2188	Transcriptional regulator
AORI_RS53690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_RS53695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_RS53730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AORI_RS53730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AORI_RS53740	COG1490	D-aminoacyl-tRNA deacylase activity
AORI_RS53745	COG2890	protein-(glutamine-N5) methyltransferase activity
AORI_RS53765	COG2313	pseudouridylate synthase activity
AORI_RS53790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AORI_RS53805	COG4213	ABC transporter substrate-binding protein
AORI_RS53815	COG4214	carbohydrate transport
AORI_RS53830	COG0596	Alpha beta hydrolase
AORI_RS53855	COG0531	amino acid
AORI_RS53915	COG0483	inositol monophosphate 1-phosphatase activity
AORI_RS53935	COG0756	dUTP diphosphatase activity
AORI_RS53965	COG0569	domain protein
AORI_RS53970	COG0531	amino acid
AORI_RS53975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AORI_RS54000	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS54005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AORI_RS54010	COG1309	transcriptional regulator
AORI_RS54015	COG0300	oxidoreductase activity
AORI_RS54025	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS54040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_RS54050	COG2801	Transposase and inactivated derivatives
AORI_RS54050	COG3415	Transposase
AORI_RS54055	COG0745	RESPONSE REGULATOR receiver
AORI_RS54060	COG2205	protein histidine kinase activity
AORI_RS54065	COG0656	L-ascorbic acid biosynthetic process
AORI_RS54075	COG1024	Enoyl-CoA hydratase
AORI_RS54075	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_RS54080	COG0183	Belongs to the thiolase family
AORI_RS54105	COG3665	Urea carboxylase-associated protein
AORI_RS54120	COG1309	transcriptional regulator
AORI_RS54130	COG2197	response regulator
AORI_RS54140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AORI_RS54150	COG3253	May function as heme-dependent peroxidase
AORI_RS54155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AORI_RS54165	COG3220	belongs to the UPF0276 family
AORI_RS54180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AORI_RS54190	COG0515	serine threonine protein kinase
AORI_RS54200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_RS54215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS54220	COG0539	negative regulation of cytoplasmic translation
AORI_RS54225	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_RS54225	COG2508	Transcriptional regulator
AORI_RS54230	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS54235	COG0506	proline dehydrogenase activity
AORI_RS54240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AORI_RS54255	COG1793	dna ligase
AORI_RS54290	COG1595	DNA-templated transcription, initiation
AORI_RS54310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_RS54320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AORI_RS54325	COG2326	polyphosphate kinase activity
AORI_RS54340	COG0446	pyridine nucleotide-disulphide oxidoreductase
AORI_RS54350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AORI_RS54355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AORI_RS54380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AORI_RS54420	COG3845	ABC transporter
AORI_RS54425	COG4603	Belongs to the binding-protein-dependent transport system permease family
AORI_RS54430	COG1079	Belongs to the binding-protein-dependent transport system permease family
AORI_RS54435	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AORI_RS54445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AORI_RS54450	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AORI_RS54455	COG0235	Class ii aldolase
AORI_RS54460	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AORI_RS54505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AORI_RS54520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AORI_RS54525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AORI_RS54550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AORI_RS54555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_RS54560	COG3842	ATPase activity
AORI_RS54565	COG1178	ABC-type Fe3 transport system permease component
AORI_RS54580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AORI_RS54585	COG1263	PTS System
AORI_RS54590	COG2188	Transcriptional regulator
AORI_RS54595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AORI_RS54630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AORI_RS54635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AORI_RS54645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AORI_RS54650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AORI_RS54655	COG0346	lactoylglutathione lyase activity
AORI_RS54670	COG0006	proline dipeptidase activity
AORI_RS54675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AORI_RS54680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AORI_RS54690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AORI_RS54695	COG0540	Belongs to the ATCase OTCase family
AORI_RS54710	COG0505	Belongs to the CarA family
AORI_RS54720	COG0284	orotidine-5'-phosphate decarboxylase activity
AORI_RS54730	COG0194	GDP metabolic process
AORI_RS54735	COG1758	RNA polymerase activity
AORI_RS54745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AORI_RS54750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AORI_RS54760	COG0405	Gamma-glutamyltransferase
AORI_RS54765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AORI_RS54785	COG2197	response regulator
AORI_RS54790	COG4585	Histidine kinase
AORI_RS54805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AORI_RS54805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AORI_RS54810	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AORI_RS54830	COG0322	excinuclease ABC activity
AORI_RS54835	COG1660	Displays ATPase and GTPase activities
AORI_RS54845	COG1481	regulation of sporulation
AORI_RS54860	COG0463	Glycosyl transferase, family 2
AORI_RS54870	COG1309	transcriptional regulator
AORI_RS54875	COG3250	beta-galactosidase activity
AORI_RS54915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AORI_RS54920	COG0126	phosphoglycerate kinase activity
AORI_RS54925	COG0149	triose-phosphate isomerase activity
AORI_RS54945	COG0363	glucosamine-6-phosphate deaminase activity
AORI_RS54960	COG0166	Belongs to the GPI family
AORI_RS54965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AORI_RS54975	COG0109	protoheme IX farnesyltransferase activity
AORI_RS55020	COG1612	heme a metabolic process
AORI_RS55055	COG0396	ATPase activity
AORI_RS55070	COG2151	metal-sulfur cluster biosynthetic enzyme
AORI_RS55075	COG1742	UPF0060 membrane protein
AORI_RS55080	COG0681	Belongs to the peptidase S26 family
AORI_RS55085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AORI_RS55100	COG4585	Histidine kinase
AORI_RS55105	COG2197	response regulator
AORI_RS55115	COG0175	sulfate reduction
AORI_RS55145	COG2199	diguanylate cyclase activity
AORI_RS55145	COG2200	EAL domain
AORI_RS55155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AORI_RS55170	COG0488	(ABC) transporter
AORI_RS55185	COG1132	(ABC) transporter
AORI_RS55195	COG4821	SIS domain
AORI_RS55200	COG2267	carboxylic ester hydrolase activity
AORI_RS55205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AORI_RS55210	COG1316	TRANSCRIPTIONal
AORI_RS55235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AORI_RS55245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AORI_RS55245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AORI_RS55255	COG1024	Enoyl-CoA hydratase
AORI_RS55280	COG1309	transcriptional regulator
AORI_RS55295	COG1960	acyl-CoA dehydrogenase activity
AORI_RS55300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_RS55320	COG1309	transcriptional regulator
AORI_RS55345	COG3469	chitinase activity
AORI_RS55365	COG0477	Major facilitator Superfamily
AORI_RS55370	COG1309	transcriptional regulator
AORI_RS55375	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS55395	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS55405	COG1309	transcriptional regulator
AORI_RS55410	COG1960	acyl-CoA dehydrogenase activity
AORI_RS55415	COG1960	acyl-CoA dehydrogenase activity
AORI_RS55420	COG1960	acyl-CoA dehydrogenase activity
AORI_RS55440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AORI_RS55445	COG0717	Belongs to the dCTP deaminase family
AORI_RS55485	COG0484	heat shock protein binding
AORI_RS55505	COG0531	amino acid
AORI_RS55510	COG1940	carbohydrate kinase activity
AORI_RS55515	COG0431	NADPH-dependent FMN reductase
AORI_RS55535	COG2124	cytochrome p450
AORI_RS55560	COG0564	pseudouridine synthase activity
AORI_RS55570	COG3629	intracellular signal transduction
AORI_RS55570	COG3903	Transcriptional regulator
AORI_RS55575	COG3903	Transcriptional regulator
AORI_RS55575	COG3629	intracellular signal transduction
AORI_RS55595	COG3629	intracellular signal transduction
AORI_RS55595	COG3903	Transcriptional regulator
AORI_RS55655	COG2197	response regulator
AORI_RS55675	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_RS55690	COG0156	8-amino-7-oxononanoate synthase activity
AORI_RS55695	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS55700	COG0604	alcohol dehydrogenase
AORI_RS55700	COG3321	synthase
AORI_RS55715	COG3321	synthase
AORI_RS55715	COG0604	alcohol dehydrogenase
AORI_RS55730	COG0604	alcohol dehydrogenase
AORI_RS55730	COG3321	synthase
AORI_RS55770	COG1280	lysine exporter protein (LysE YggA)
AORI_RS55775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS55805	COG4977	sequence-specific DNA binding
AORI_RS55820	COG1116	anion transmembrane transporter activity
AORI_RS55825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AORI_RS55830	COG0601	transmembrane transport
AORI_RS55835	COG4166	transmembrane transport
AORI_RS55845	COG0025	NhaP-type Na H and K H
AORI_RS55875	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AORI_RS55880	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AORI_RS55885	COG2197	response regulator
AORI_RS55890	COG4585	Histidine kinase
AORI_RS55905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AORI_RS55955	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS55960	COG1309	transcriptional regulator
AORI_RS55965	COG1414	Transcriptional regulator
AORI_RS55970	COG3734	2-keto-3-deoxy-galactonokinase
AORI_RS55975	COG0800	Aldolase
AORI_RS55980	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_RS55985	COG2271	Major facilitator Superfamily
AORI_RS55990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_RS56000	COG1595	DNA-templated transcription, initiation
AORI_RS56005	COG0666	response to abiotic stimulus
AORI_RS56015	COG4585	Histidine kinase
AORI_RS56020	COG2197	response regulator
AORI_RS56025	COG0667	Aldo Keto reductase
AORI_RS56055	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS56080	COG2610	gluconate transmembrane transporter activity
AORI_RS56090	COG0473	3-isopropylmalate dehydrogenase activity
AORI_RS56115	COG0604	alcohol dehydrogenase
AORI_RS56155	COG0583	DNA-binding transcription factor activity
AORI_RS56160	COG0702	epimerase
AORI_RS56165	COG1819	glycosyl
AORI_RS56170	COG2197	response regulator
AORI_RS56185	COG2197	response regulator
AORI_RS56235	COG1131	(ABC) transporter
AORI_RS56245	COG2197	response regulator
AORI_RS56270	COG0789	Transcriptional regulator
AORI_RS56315	COG2124	cytochrome p450
AORI_RS56325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AORI_RS56330	COG0463	Glycosyl transferase, family 2
AORI_RS56335	COG2195	Cleaves the N-terminal amino acid of tripeptides
AORI_RS56345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AORI_RS56350	COG3795	YCII-related domain
AORI_RS56355	COG4941	Belongs to the sigma-70 factor family
AORI_RS56360	COG1349	DNA-binding transcription factor activity
AORI_RS56380	COG3706	GGDEF domain
AORI_RS56385	COG2814	Major facilitator Superfamily
AORI_RS56420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AORI_RS56425	COG0328	RNA-DNA hybrid ribonuclease activity
AORI_RS56440	COG2205	protein histidine kinase activity
AORI_RS56445	COG0745	RESPONSE REGULATOR receiver
AORI_RS56455	COG3706	GGDEF domain
AORI_RS56465	COG3903	Transcriptional regulator
AORI_RS56465	COG3629	intracellular signal transduction
AORI_RS56470	COG0697	spore germination
AORI_RS56510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS56535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS56540	COG1053	succinate dehydrogenase
AORI_RS56555	COG0154	amidase activity
AORI_RS56560	COG1414	Transcriptional regulator
AORI_RS56565	COG0515	serine threonine protein kinase
AORI_RS56565	COG2815	serine threonine protein kinase
AORI_RS56575	COG2124	cytochrome p450
AORI_RS56585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_RS56590	COG1733	regulation of RNA biosynthetic process
AORI_RS56595	COG1309	transcriptional regulator
AORI_RS56600	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS56605	COG0028	Belongs to the TPP enzyme family
AORI_RS56665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS56675	COG1573	uracil-dna glycosylase
AORI_RS56685	COG3655	Transcriptional regulator
AORI_RS56725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AORI_RS56725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AORI_RS56755	COG0017	Asparaginyl-tRNA synthetase
AORI_RS56760	COG0069	glutamate synthase activity
AORI_RS56795	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AORI_RS56800	COG1834	amidinotransferase
AORI_RS56805	COG0475	glutathione-regulated potassium exporter activity
AORI_RS56815	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS56820	COG0859	PFAM glycosyl transferase family 9
AORI_RS56860	COG0704	Plays a role in the regulation of phosphate uptake
AORI_RS56885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_RS56895	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS56900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AORI_RS56900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AORI_RS56905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AORI_RS56910	COG2192	nodulation
AORI_RS56915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_RS56935	COG0438	transferase activity, transferring glycosyl groups
AORI_RS56950	COG2890	protein-(glutamine-N5) methyltransferase activity
AORI_RS56965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_RS56970	COG0723	plastoquinol--plastocyanin reductase activity
AORI_RS56975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AORI_RS56995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_RS57025	COG3629	intracellular signal transduction
AORI_RS57025	COG3903	Transcriptional regulator
AORI_RS57050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AORI_RS57055	COG1335	isochorismatase
AORI_RS57100	COG2356	endonuclease I
AORI_RS57105	COG0456	acetyltransferase
AORI_RS57125	COG3345	alpha-galactosidase
AORI_RS57140	COG1222	aaa ATPase
AORI_RS57240	COG2197	response regulator
AORI_RS57245	COG2197	response regulator
AORI_RS57280	COG0300	oxidoreductase activity
AORI_RS57280	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS57280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_RS57280	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS57280	COG3321	synthase
AORI_RS57285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_RS57285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_RS57330	COG0477	Major facilitator Superfamily
AORI_RS57360	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS57365	COG0531	amino acid
AORI_RS57385	COG1131	(ABC) transporter
AORI_RS57400	COG3835	regulator
AORI_RS57405	COG3835	regulator
AORI_RS57420	COG2814	Major facilitator Superfamily
AORI_RS57430	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS57470	COG2197	response regulator
AORI_RS57500	COG3629	intracellular signal transduction
AORI_RS57500	COG3903	Transcriptional regulator
AORI_RS57505	COG0736	holo-[acyl-carrier-protein] synthase activity
AORI_RS57520	COG0736	holo-[acyl-carrier-protein] synthase activity
AORI_RS57530	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AORI_RS57550	COG0736	holo-[acyl-carrier-protein] synthase activity
AORI_RS57560	COG4585	Histidine kinase
AORI_RS57565	COG2197	response regulator
AORI_RS57570	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS57600	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_RS57600	COG2319	Wd-40 repeat
AORI_RS57620	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AORI_RS57620	COG1672	PFAM Archaeal ATPase
AORI_RS57645	COG1674	ftsk spoiiie
AORI_RS57725	COG2255	four-way junction helicase activity
AORI_RS57730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS57750	COG1960	acyl-CoA dehydrogenase activity
AORI_RS57765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AORI_RS57770	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS57780	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AORI_RS57785	COG1522	sequence-specific DNA binding
AORI_RS57790	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS57795	COG3268	Saccharopine dehydrogenase
AORI_RS57800	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS57830	COG3291	Pkd domain containing protein
AORI_RS57830	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AORI_RS57845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AORI_RS57905	COG0702	epimerase
AORI_RS57975	COG0596	Alpha beta hydrolase
AORI_RS57990	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS58000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_RS58035	COG2132	Multicopper oxidase
AORI_RS58045	COG0583	DNA-binding transcription factor activity
AORI_RS58080	COG2814	Major facilitator Superfamily
AORI_RS58105	COG3903	Transcriptional regulator
AORI_RS58105	COG3629	intracellular signal transduction
AORI_RS58160	COG0673	inositol 2-dehydrogenase activity
AORI_RS58240	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AORI_RS58245	COG0714	Associated with various cellular activities
AORI_RS58265	COG3226	Transcriptional regulator
AORI_RS58290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AORI_RS58315	COG0277	FAD linked oxidase domain protein
AORI_RS58320	COG0583	DNA-binding transcription factor activity
AORI_RS58335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_RS58355	COG1609	Transcriptional regulator
AORI_RS58375	COG1609	Transcriptional regulator
AORI_RS58390	COG0395	ABC-type sugar transport system, permease component
AORI_RS58395	COG4209	transmembrane transport
AORI_RS58405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AORI_RS58415	COG0596	Alpha beta hydrolase
AORI_RS58425	COG0667	Aldo Keto reductase
AORI_RS58440	COG0583	DNA-binding transcription factor activity
AORI_RS58470	COG1764	response to oxidative stress
AORI_RS58475	COG3903	Transcriptional regulator
AORI_RS58475	COG3629	intracellular signal transduction
AORI_RS58480	COG0366	Alpha amylase catalytic
AORI_RS58490	COG1175	transmembrane transport
AORI_RS58500	COG1609	Transcriptional regulator
AORI_RS58530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AORI_RS58535	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AORI_RS58535	COG1082	Xylose isomerase domain protein TIM barrel
AORI_RS58560	COG1414	Transcriptional regulator
AORI_RS58565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AORI_RS58570	COG0277	FAD linked oxidase domain protein
AORI_RS58580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS58590	COG1309	transcriptional regulator
AORI_RS58595	COG2186	Transcriptional regulator
AORI_RS58605	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS58610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AORI_RS58610	COG0825	malonyl-CoA metabolic process
AORI_RS58620	COG4977	sequence-specific DNA binding
AORI_RS58635	COG0745	RESPONSE REGULATOR receiver
AORI_RS58640	COG2205	protein histidine kinase activity
AORI_RS58650	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS58655	COG1169	isochorismate synthase
AORI_RS58660	COG1021	2,3-dihydroxybenzoate-AMP ligase
AORI_RS58665	COG3433	isochorismatase activity
AORI_RS58665	COG1535	isochorismatase
AORI_RS58670	COG1535	isochorismatase
AORI_RS58670	COG3433	isochorismatase activity
AORI_RS58675	COG2375	cellular response to nickel ion
AORI_RS58680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AORI_RS58685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS58690	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS58695	COG1120	ATPase activity
AORI_RS58710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AORI_RS58775	COG0701	Predicted permease
AORI_RS58785	COG5504	Zn-dependent protease
AORI_RS58795	COG1802	Transcriptional regulator
AORI_RS58800	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS58825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AORI_RS58850	COG0601	transmembrane transport
AORI_RS58855	COG0747	negative chemotaxis
AORI_RS58870	COG0657	acetylesterase activity
AORI_RS58880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AORI_RS58935	COG4977	sequence-specific DNA binding
AORI_RS58960	COG1253	flavin adenine dinucleotide binding
AORI_RS58965	COG0129	dihydroxy-acid dehydratase activity
AORI_RS58985	COG4585	Histidine kinase
AORI_RS58990	COG2197	response regulator
AORI_RS59000	COG1119	ATPase activity
AORI_RS59010	COG1366	Belongs to the anti-sigma-factor antagonist family
AORI_RS59035	COG0583	DNA-binding transcription factor activity
AORI_RS59040	COG0006	proline dipeptidase activity
AORI_RS59070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_RS59075	COG3938	Belongs to the proline racemase family
AORI_RS59080	COG0531	amino acid
AORI_RS59090	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AORI_RS59100	COG0477	Major facilitator Superfamily
AORI_RS59140	COG0791	NLP P60 protein
AORI_RS59140	COG1388	LysM domain
AORI_RS59140	COG3103	Sh3 type 3 domain protein
AORI_RS59150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AORI_RS59200	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AORI_RS59205	COG2508	Transcriptional regulator
AORI_RS59205	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_RS59230	COG1295	ribonuclease BN
AORI_RS59295	COG1024	Enoyl-CoA hydratase
AORI_RS59305	COG0488	(ABC) transporter
AORI_RS59310	COG0395	ABC-type sugar transport system, permease component
AORI_RS59340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AORI_RS59365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AORI_RS59370	COG1132	(ABC) transporter
AORI_RS59375	COG1132	(ABC) transporter
AORI_RS59380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS59385	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS59400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_RS59405	COG3415	Transposase
AORI_RS59405	COG2801	Transposase and inactivated derivatives
AORI_RS59440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS59470	COG0640	Transcriptional regulator
AORI_RS59480	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS59490	COG0523	cobalamin synthesis protein
AORI_RS59500	COG0254	rRNA binding
AORI_RS59510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AORI_RS59515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AORI_RS59520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AORI_RS59535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AORI_RS59535	COG1648	precorrin-2 dehydrogenase activity
AORI_RS59550	COG1024	Enoyl-CoA hydratase
AORI_RS59555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_RS59610	COG0509	glycine decarboxylation via glycine cleavage system
AORI_RS59615	COG1716	ATPase activity
AORI_RS59640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AORI_RS59640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AORI_RS59655	COG0656	L-ascorbic acid biosynthetic process
AORI_RS59710	COG2267	carboxylic ester hydrolase activity
AORI_RS59715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AORI_RS59720	COG0583	DNA-binding transcription factor activity
AORI_RS59725	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AORI_RS59730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AORI_RS59735	COG0121	glutamine amidotransferase
AORI_RS59740	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AORI_RS59765	COG0477	Major facilitator Superfamily
AORI_RS59785	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AORI_RS59790	COG3883	PFAM NLP P60 protein
AORI_RS59790	COG0791	NLP P60 protein
AORI_RS59805	COG0714	Associated with various cellular activities
AORI_RS59815	COG2304	oxidoreductase activity
AORI_RS59820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AORI_RS59825	COG3540	Alkaline phosphatase
AORI_RS59845	COG2205	protein histidine kinase activity
AORI_RS59850	COG0745	RESPONSE REGULATOR receiver
AORI_RS59855	COG0477	Major facilitator Superfamily
AORI_RS59865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AORI_RS59885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AORI_RS59890	COG1278	Cold shock
AORI_RS59895	COG3226	Transcriptional regulator
AORI_RS59900	COG0596	Alpha beta hydrolase
AORI_RS59925	COG0789	Transcriptional regulator
AORI_RS59930	COG0215	cysteine-tRNA ligase activity
AORI_RS59935	COG0488	(ABC) transporter
AORI_RS59950	COG2814	Major facilitator Superfamily
AORI_RS59955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AORI_RS59980	COG0140	phosphoribosyl-ATP diphosphatase activity
AORI_RS59985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AORI_RS59990	COG1192	Involved in chromosome partitioning
AORI_RS60005	COG1994	Peptidase M50
AORI_RS60005	COG0517	IMP dehydrogenase activity
AORI_RS60025	COG1222	aaa ATPase
AORI_RS60050	COG1051	belongs to the nudix hydrolase family
AORI_RS60065	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AORI_RS60070	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AORI_RS60085	COG1597	lipid kinase activity
AORI_RS60090	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AORI_RS60115	COG4447	cellulose binding
AORI_RS60120	COG0640	Transcriptional regulator
AORI_RS60140	COG0604	alcohol dehydrogenase
AORI_RS60145	COG1733	regulation of RNA biosynthetic process
AORI_RS60155	COG2378	regulation of single-species biofilm formation
AORI_RS60165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AORI_RS60175	COG1597	lipid kinase activity
AORI_RS60205	COG4552	Acetyltransferase involved in intracellular survival and related
AORI_RS60260	COG0583	DNA-binding transcription factor activity
AORI_RS60265	COG4221	oxidoreductase activity
AORI_RS60295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_RS60300	COG2362	D-Aminopeptidase
AORI_RS60310	COG0488	(ABC) transporter
AORI_RS60330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AORI_RS60340	COG1595	DNA-templated transcription, initiation
AORI_RS60395	COG0601	transmembrane transport
AORI_RS60425	COG1619	proteins homologs of microcin C7 resistance protein MccF
AORI_RS60475	COG0477	Major facilitator Superfamily
AORI_RS60480	COG0431	NADPH-dependent FMN reductase
AORI_RS60490	COG0640	Transcriptional regulator
AORI_RS60500	COG1309	transcriptional regulator
AORI_RS60535	COG1309	transcriptional regulator
AORI_RS60540	COG4585	Histidine kinase
AORI_RS60545	COG2197	response regulator
AORI_RS60550	COG0596	Alpha beta hydrolase
AORI_RS60560	COG0583	DNA-binding transcription factor activity
AORI_RS60565	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS60585	COG0590	tRNA wobble adenosine to inosine editing
AORI_RS60595	COG1522	sequence-specific DNA binding
AORI_RS60605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_RS60635	COG2226	methyltransferase
AORI_RS60645	COG1309	transcriptional regulator
AORI_RS60650	COG4974	Belongs to the 'phage' integrase family
AORI_RS60680	COG2755	lipolytic protein G-D-S-L family
AORI_RS60690	COG1357	PFAM Pentapeptide repeats (8 copies)
AORI_RS60710	COG0702	epimerase
AORI_RS60725	COG4941	Belongs to the sigma-70 factor family
AORI_RS60765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AORI_RS60785	COG1960	acyl-CoA dehydrogenase activity
AORI_RS60790	COG1309	transcriptional regulator
AORI_RS60800	COG1595	DNA-templated transcription, initiation
AORI_RS60805	COG2318	DinB family
AORI_RS60815	COG2890	protein-(glutamine-N5) methyltransferase activity
AORI_RS60820	COG2226	methyltransferase
AORI_RS60825	COG2226	methyltransferase
AORI_RS60840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AORI_RS60865	COG1435	thymidine kinase activity
AORI_RS60905	COG0463	Glycosyl transferase, family 2
AORI_RS60915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AORI_RS60920	COG1509	lysine 2,3-aminomutase activity
AORI_RS60925	COG2814	Major facilitator Superfamily
AORI_RS60935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AORI_RS60940	COG0277	FAD linked oxidase domain protein
AORI_RS60970	COG0583	DNA-binding transcription factor activity
AORI_RS60980	COG3485	protocatechuate 3,4-dioxygenase
AORI_RS60985	COG4829	muconolactone delta-isomerase
AORI_RS60990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AORI_RS60995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AORI_RS61000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AORI_RS61005	COG2423	ornithine cyclodeaminase activity
AORI_RS61025	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_RS61025	COG2508	Transcriptional regulator
AORI_RS61030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_RS61040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AORI_RS61060	COG2272	Belongs to the type-B carboxylesterase lipase family
AORI_RS61065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AORI_RS61070	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AORI_RS61075	COG2080	2 iron, 2 sulfur cluster binding
AORI_RS61085	COG1309	transcriptional regulator
AORI_RS61090	COG0604	alcohol dehydrogenase
AORI_RS61090	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS61090	COG3321	synthase
AORI_RS61105	COG0028	Belongs to the TPP enzyme family
AORI_RS61140	COG0527	aspartate kinase activity
AORI_RS61160	COG4585	Histidine kinase
AORI_RS61165	COG2197	response regulator
AORI_RS61185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AORI_RS61190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AORI_RS61245	COG0387	Pfam Sodium calcium exchanger
AORI_RS61250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AORI_RS61270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AORI_RS61275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_RS61275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_RS61280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_RS61295	COG2226	methyltransferase
AORI_RS61310	COG1309	transcriptional regulator
AORI_RS61320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AORI_RS61335	COG0697	spore germination
AORI_RS61345	COG2084	Dehydrogenase
AORI_RS61365	COG1136	(ABC) transporter
AORI_RS61370	COG1136	(ABC) transporter
AORI_RS61380	COG3537	Alpha-1,2-mannosidase
AORI_RS61385	COG0477	Major facilitator Superfamily
AORI_RS61400	COG1090	epimerase
AORI_RS61425	COG1846	Transcriptional regulator
AORI_RS61430	COG0039	L-malate dehydrogenase activity
AORI_RS61460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS61465	COG1104	cysteine desulfurase activity
AORI_RS61470	COG0339	signal peptide processing
AORI_RS61480	COG1968	undecaprenyl-diphosphatase activity
AORI_RS61485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS61490	COG0667	Aldo Keto reductase
AORI_RS61520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_RS61525	COG0860	N-Acetylmuramoyl-L-alanine amidase
AORI_RS61525	COG3409	Peptidoglycan-binding domain 1 protein
AORI_RS61530	COG0739	heme binding
AORI_RS61545	COG3540	Alkaline phosphatase
AORI_RS61565	COG2197	response regulator
AORI_RS61570	COG4585	Histidine kinase
AORI_RS61585	COG0427	acetyl-CoA hydrolase
AORI_RS61615	COG3546	catalase activity
AORI_RS61630	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS61650	COG3404	Formiminotransferase-cyclodeaminase
AORI_RS61655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AORI_RS61745	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS61785	COG2115	Belongs to the xylose isomerase family
AORI_RS61790	COG1940	carbohydrate kinase activity
AORI_RS61815	COG0508	dehydrogenase complex catalyzes the overall conversion of
AORI_RS61835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AORI_RS61845	COG0477	Major facilitator Superfamily
AORI_RS61870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS61900	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_RS61905	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_RS61910	COG1129	ABC transporter
AORI_RS61920	COG1609	Transcriptional regulator
AORI_RS61925	COG4585	Histidine kinase
AORI_RS61930	COG2197	response regulator
AORI_RS61970	COG1136	(ABC) transporter
AORI_RS61970	COG0577	efflux transmembrane transporter activity
AORI_RS61975	COG0154	amidase activity
AORI_RS61980	COG0477	Major facilitator Superfamily
AORI_RS61990	COG4566	intracellular signal transduction
AORI_RS61995	COG0154	amidase activity
AORI_RS62025	COG4638	Rieske (2fe-2S)
AORI_RS62035	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS62065	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AORI_RS62075	COG0745	RESPONSE REGULATOR receiver
AORI_RS62090	COG4608	Belongs to the ABC transporter superfamily
AORI_RS62095	COG0444	Belongs to the ABC transporter superfamily
AORI_RS62125	COG2271	Major facilitator Superfamily
AORI_RS62130	COG2508	Transcriptional regulator
AORI_RS62130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_RS62135	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_RS62150	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AORI_RS62160	COG0395	ABC-type sugar transport system, permease component
AORI_RS62165	COG1175	transmembrane transport
AORI_RS62195	COG1733	regulation of RNA biosynthetic process
AORI_RS62205	COG1846	Transcriptional regulator
AORI_RS62215	COG2814	Major facilitator Superfamily
AORI_RS62220	COG2755	lipolytic protein G-D-S-L family
AORI_RS62220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AORI_RS62225	COG5002	protein histidine kinase activity
AORI_RS62230	COG0745	RESPONSE REGULATOR receiver
AORI_RS62250	COG0395	ABC-type sugar transport system, permease component
AORI_RS62255	COG1175	transmembrane transport
AORI_RS62260	COG1609	Transcriptional regulator
AORI_RS62265	COG0702	epimerase
AORI_RS62270	COG1846	Transcriptional regulator
AORI_RS62275	COG2409	Drug exporters of the RND superfamily
AORI_RS62320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AORI_RS62355	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AORI_RS62370	COG0537	adenosine 5'-monophosphoramidase activity
AORI_RS62385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AORI_RS62410	COG0477	Major facilitator Superfamily
AORI_RS62425	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS62435	COG3971	2-oxopent-4-enoate hydratase activity
AORI_RS62485	COG3250	beta-galactosidase activity
AORI_RS62490	COG3940	Belongs to the glycosyl hydrolase 43 family
AORI_RS62500	COG4214	carbohydrate transport
AORI_RS62505	COG1129	ABC transporter
AORI_RS62510	COG4213	ABC transporter substrate-binding protein
AORI_RS62515	COG2160	L-arabinose isomerase activity
AORI_RS62530	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_RS62535	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_RS62545	COG1879	ABC-type sugar transport system periplasmic component
AORI_RS62550	COG1609	Transcriptional regulator
AORI_RS62570	COG0395	ABC-type sugar transport system, permease component
AORI_RS62580	COG0488	(ABC) transporter
AORI_RS62595	COG4106	trans-aconitate 2-methyltransferase activity
AORI_RS62605	COG1309	transcriptional regulator
AORI_RS62615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_RS62645	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS62650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_RS62655	COG2197	response regulator
AORI_RS62665	COG4977	sequence-specific DNA binding
AORI_RS62710	COG2201	protein-glutamate methylesterase activity
AORI_RS62750	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AORI_RS62770	COG1522	sequence-specific DNA binding
AORI_RS62775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AORI_RS62780	COG3285	dna ligase
AORI_RS62780	COG1793	dna ligase
AORI_RS62805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AORI_RS62815	COG2366	antibiotic biosynthetic process
AORI_RS62835	COG3960	tartronate-semialdehyde synthase activity
AORI_RS62840	COG2084	Dehydrogenase
AORI_RS62845	COG3622	Belongs to the hyi family
AORI_RS62850	COG0596	Alpha beta hydrolase
AORI_RS62860	COG0596	Alpha beta hydrolase
AORI_RS62870	COG1280	lysine exporter protein (LysE YggA)
AORI_RS62885	COG3795	YCII-related domain
AORI_RS62895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AORI_RS62910	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AORI_RS62930	COG2018	Roadblock/LC7 domain
AORI_RS62980	COG3903	Transcriptional regulator
AORI_RS62980	COG3629	intracellular signal transduction
AORI_RS63010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_RS63015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AORI_RS63020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AORI_RS63025	COG0154	amidase activity
AORI_RS63030	COG1024	Enoyl-CoA hydratase
AORI_RS63035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AORI_RS63040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AORI_RS63045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AORI_RS63060	COG2255	four-way junction helicase activity
AORI_RS63065	COG0632	four-way junction helicase activity
AORI_RS63070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AORI_RS63085	COG0217	transcriptional regulatory protein
AORI_RS63090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AORI_RS63105	COG1396	sequence-specific DNA binding
AORI_RS63125	COG3903	Transcriptional regulator
AORI_RS63125	COG3629	intracellular signal transduction
AORI_RS63145	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AORI_RS63150	COG0277	FAD linked oxidase domain protein
AORI_RS63160	COG3608	succinylglutamate desuccinylase aspartoacylase
AORI_RS63160	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AORI_RS63170	COG0438	transferase activity, transferring glycosyl groups
AORI_RS63175	COG1560	Kdo2-lipid A biosynthetic process
AORI_RS63200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AORI_RS63205	COG0778	Nitroreductase
AORI_RS63305	COG1388	LysM domain
AORI_RS63305	COG3103	Sh3 type 3 domain protein
AORI_RS63305	COG0791	NLP P60 protein
AORI_RS63330	COG3293	Transposase
AORI_RS63455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AORI_RS63460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AORI_RS63470	COG1051	belongs to the nudix hydrolase family
AORI_RS63480	COG0587	DNA-directed DNA polymerase activity
AORI_RS63515	COG0587	DNA-directed DNA polymerase activity
AORI_RS63540	COG3285	dna ligase
AORI_RS63540	COG1793	dna ligase
AORI_RS63590	COG3903	Transcriptional regulator
AORI_RS63590	COG3629	intracellular signal transduction
AORI_RS63620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AORI_RS63620	COG5479	isomerase activity
AORI_RS63750	COG3629	intracellular signal transduction
AORI_RS63750	COG3903	Transcriptional regulator
AORI_RS63765	COG0604	alcohol dehydrogenase
AORI_RS63790	COG3328	transposase activity
AORI_RS63845	COG0515	serine threonine protein kinase
AORI_RS63845	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AORI_RS63955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AORI_RS63970	COG0574	Belongs to the PEP-utilizing enzyme family
AORI_RS63970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AORI_RS63975	COG0517	IMP dehydrogenase activity
AORI_RS63975	COG0516	GMP reductase activity
AORI_RS64000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AORI_RS64025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AORI_RS64075	COG1042	CoA-binding domain protein
AORI_RS64075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_RS64075	COG0045	succinate-CoA ligase (ADP-forming) activity
AORI_RS64080	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AORI_RS64080	COG0517	IMP dehydrogenase activity
AORI_RS64080	COG0617	tRNA 3'-terminal CCA addition
AORI_RS64095	COG0589	response to stress
AORI_RS64130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AORI_RS64140	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AORI_RS64150	COG0517	IMP dehydrogenase activity
AORI_RS64150	COG0516	GMP reductase activity
AORI_RS64170	COG1470	cell adhesion involved in biofilm formation
AORI_RS64200	COG0604	alcohol dehydrogenase
AORI_RS64200	COG3321	synthase
AORI_RS64215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AORI_RS64220	COG3629	intracellular signal transduction
AORI_RS64220	COG3903	Transcriptional regulator
AORI_RS64255	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_RS64255	COG2319	Wd-40 repeat
AORI_RS64280	COG2850	peptidyl-arginine hydroxylation
AORI_RS64330	COG1051	belongs to the nudix hydrolase family
AORI_RS64340	COG0477	Major facilitator Superfamily
AORI_RS64350	COG3903	Transcriptional regulator
AORI_RS64350	COG3629	intracellular signal transduction
AORI_RS64375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_RS64395	COG2208	phosphoserine phosphatase activity
AORI_RS64395	COG2770	Histidine kinase
AORI_RS64415	COG1366	Belongs to the anti-sigma-factor antagonist family
AORI_RS64420	COG1366	Belongs to the anti-sigma-factor antagonist family
AORI_RS64425	COG2172	sigma factor antagonist activity
AORI_RS64495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AORI_RS64510	COG0596	Alpha beta hydrolase
AORI_RS64530	COG2197	response regulator
AORI_RS64545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AORI_RS64545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AORI_RS64585	COG0798	PFAM Bile acid sodium symporter
AORI_RS64590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AORI_RS64610	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AORI_RS64610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_RS64625	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS64635	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS64640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AORI_RS64645	COG0174	glutamine synthetase
AORI_RS64655	COG1607	acyl-coa hydrolase
AORI_RS64660	COG2072	flavoprotein involved in K transport
AORI_RS64665	COG0657	acetylesterase activity
AORI_RS64700	COG1113	amino acid transport
AORI_RS64710	COG2855	membrane
AORI_RS64720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AORI_RS64730	COG1414	Transcriptional regulator
AORI_RS64770	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AORI_RS64775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS64795	COG2197	response regulator
AORI_RS64815	COG0596	Alpha beta hydrolase
AORI_RS64840	COG0477	Major facilitator Superfamily
AORI_RS64850	COG3473	Maleate cis-trans isomerase
AORI_RS64855	COG2309	aminopeptidase activity
AORI_RS64865	COG0778	Nitroreductase
AORI_RS64870	COG3903	Transcriptional regulator
AORI_RS64870	COG3629	intracellular signal transduction
AORI_RS64885	COG1733	regulation of RNA biosynthetic process
AORI_RS64935	COG1522	sequence-specific DNA binding
AORI_RS64945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AORI_RS64960	COG0488	(ABC) transporter
AORI_RS64975	COG0488	(ABC) transporter
AORI_RS64985	COG0515	serine threonine protein kinase
AORI_RS64985	COG2815	serine threonine protein kinase
AORI_RS65005	COG0784	Response regulator, receiver
AORI_RS65010	COG4251	negative regulation of phosphorylation
AORI_RS65015	COG0745	RESPONSE REGULATOR receiver
AORI_RS65025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS65045	COG1819	glycosyl
AORI_RS65050	COG0300	oxidoreductase activity
AORI_RS65065	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS65070	COG3321	synthase
AORI_RS65070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_RS65075	COG0477	Major facilitator Superfamily
AORI_RS65100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AORI_RS65100	COG0515	serine threonine protein kinase
AORI_RS65105	COG0515	serine threonine protein kinase
AORI_RS65105	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AORI_RS65175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AORI_RS65200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_RS65235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AORI_RS65245	COG0604	alcohol dehydrogenase
AORI_RS65245	COG3321	synthase
AORI_RS65250	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS65255	COG0667	Aldo Keto reductase
AORI_RS65260	COG2826	transposase and inactivated derivatives, IS30 family
AORI_RS65265	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_RS65280	COG1959	2 iron, 2 sulfur cluster binding
AORI_RS65290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AORI_RS65295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AORI_RS65305	COG1414	Transcriptional regulator
AORI_RS65310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AORI_RS65335	COG3511	phospholipase C
AORI_RS65350	COG1335	isochorismatase
AORI_RS65365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AORI_RS65370	COG2755	lipolytic protein G-D-S-L family
AORI_RS65370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AORI_RS65375	COG2318	DinB family
AORI_RS65425	COG0583	DNA-binding transcription factor activity
AORI_RS65430	COG2814	Major facilitator Superfamily
AORI_RS65445	COG0583	DNA-binding transcription factor activity
AORI_RS65460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AORI_RS65460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AORI_RS65470	COG1309	transcriptional regulator
AORI_RS65520	COG2197	response regulator
AORI_RS65535	COG2072	flavoprotein involved in K transport
AORI_RS65540	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS65550	COG1309	transcriptional regulator
AORI_RS65560	COG2301	Belongs to the HpcH HpaI aldolase family
AORI_RS65565	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AORI_RS65575	COG1960	acyl-CoA dehydrogenase activity
AORI_RS65590	COG0477	Major facilitator Superfamily
AORI_RS65630	COG1063	alcohol dehydrogenase
AORI_RS65635	COG0454	-acetyltransferase
AORI_RS65635	COG0456	acetyltransferase
AORI_RS65650	COG1132	(ABC) transporter
AORI_RS65655	COG1309	transcriptional regulator
AORI_RS65665	COG1064	alcohol dehydrogenase
AORI_RS65690	COG4106	trans-aconitate 2-methyltransferase activity
AORI_RS65700	COG2409	Drug exporters of the RND superfamily
AORI_RS65705	COG1309	transcriptional regulator
AORI_RS65725	COG3629	intracellular signal transduction
AORI_RS65725	COG3903	Transcriptional regulator
AORI_RS65730	COG2197	response regulator
AORI_RS65735	COG4585	Histidine kinase
AORI_RS65740	COG2315	Protein conserved in bacteria
AORI_RS65755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AORI_RS65760	COG0028	Belongs to the TPP enzyme family
AORI_RS65770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_RS65775	COG1403	HNH endonuclease
AORI_RS65780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AORI_RS65785	COG1595	DNA-templated transcription, initiation
AORI_RS65795	COG2188	Transcriptional regulator
AORI_RS65810	COG3629	intracellular signal transduction
AORI_RS65810	COG3903	Transcriptional regulator
AORI_RS65815	COG0596	Alpha beta hydrolase
AORI_RS65835	COG4991	sh3 domain protein
AORI_RS65865	COG0500	methyltransferase
AORI_RS65900	COG4981	capsule polysaccharide biosynthetic process
AORI_RS65955	COG0596	Alpha beta hydrolase
AORI_RS65960	COG5492	domain, Protein
AORI_RS65975	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_RS65980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_RS65990	COG1414	Transcriptional regulator
AORI_RS65995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_RS66015	COG1846	Transcriptional regulator
AORI_RS66025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AORI_RS66045	COG3848	Pyruvate phosphate dikinase
AORI_RS66045	COG0574	Belongs to the PEP-utilizing enzyme family
AORI_RS66065	COG1160	GTP binding
AORI_RS66095	COG0475	glutathione-regulated potassium exporter activity
AORI_RS66100	COG2936	dipeptidyl-peptidase activity
AORI_RS66110	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AORI_RS66140	COG0494	nUDIX hydrolase
AORI_RS66145	COG0504	CTP synthase activity
AORI_RS66150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AORI_RS66160	COG1802	Transcriptional regulator
AORI_RS66165	COG1953	Uracil, thiamine, allantoin
AORI_RS66190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AORI_RS66205	COG0647	UMP catabolic process
AORI_RS66230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AORI_RS66235	COG2094	Belongs to the DNA glycosylase MPG family
AORI_RS66250	COG0165	Argininosuccinate lyase
AORI_RS66255	COG0137	argininosuccinate synthase activity
AORI_RS66260	COG1438	arginine binding
AORI_RS66265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AORI_RS66270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AORI_RS66275	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AORI_RS66280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AORI_RS66285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AORI_RS66320	COG0072	phenylalanine-tRNA ligase activity
AORI_RS66320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AORI_RS66325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AORI_RS66330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AORI_RS66335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AORI_RS66340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AORI_RS66355	COG1802	Transcriptional regulator
AORI_RS66365	COG0251	oxidation-reduction process
AORI_RS66385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AORI_RS66390	COG2610	gluconate transmembrane transporter activity
AORI_RS66395	COG2706	6-phosphogluconolactonase activity
AORI_RS66405	COG1175	transmembrane transport
AORI_RS66410	COG0395	ABC-type sugar transport system, permease component
AORI_RS66450	COG4565	transcriptional regulatory protein
AORI_RS66455	COG3290	protein histidine kinase activity
AORI_RS66460	COG1301	dicarboxylic acid transport
AORI_RS66470	COG1733	regulation of RNA biosynthetic process
AORI_RS66515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_RS66565	COG0789	Transcriptional regulator
AORI_RS66605	COG3012	SEC-C Motif Domain Protein
AORI_RS66610	COG3250	beta-galactosidase activity
AORI_RS66655	COG1070	Carbohydrate kinase
AORI_RS66660	COG1609	Transcriptional regulator
AORI_RS66680	COG0823	Involved in the tonB-independent uptake of proteins
AORI_RS66680	COG4946	Tricorn protease homolog
AORI_RS66680	COG1506	peptidase
AORI_RS66690	COG1131	(ABC) transporter
AORI_RS66705	COG1024	Enoyl-CoA hydratase
AORI_RS66740	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AORI_RS66740	COG0237	dephospho-CoA kinase activity
AORI_RS66750	COG0539	negative regulation of cytoplasmic translation
AORI_RS66755	COG2226	methyltransferase
AORI_RS66775	COG1511	domain protein
AORI_RS66790	COG1653	transport
AORI_RS66825	COG0583	DNA-binding transcription factor activity
AORI_RS66870	COG0583	DNA-binding transcription factor activity
AORI_RS66885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AORI_RS66890	COG1501	Belongs to the glycosyl hydrolase 31 family
AORI_RS66895	COG1349	DNA-binding transcription factor activity
AORI_RS66905	COG3842	ATPase activity
AORI_RS66910	COG0395	ABC-type sugar transport system, permease component
AORI_RS66915	COG1175	transmembrane transport
AORI_RS66930	COG1105	Belongs to the carbohydrate kinase PfkB family
AORI_RS66935	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AORI_RS66955	COG2188	Transcriptional regulator
AORI_RS66975	COG2066	Belongs to the glutaminase family
AORI_RS67005	COG0583	DNA-binding transcription factor activity
AORI_RS67020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AORI_RS67030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AORI_RS67145	COG0559	Belongs to the binding-protein-dependent transport system permease family
AORI_RS67170	COG1846	Transcriptional regulator
AORI_RS67180	COG1902	pentaerythritol trinitrate reductase activity
AORI_RS67195	COG0515	serine threonine protein kinase
AORI_RS67200	COG0740	serine-type endopeptidase activity
AORI_RS67205	COG0740	serine-type endopeptidase activity
AORI_RS67245	COG2197	response regulator
AORI_RS67255	COG3903	Transcriptional regulator
AORI_RS67255	COG3629	intracellular signal transduction
AORI_RS67260	COG3903	Transcriptional regulator
AORI_RS67260	COG3629	intracellular signal transduction
AORI_RS67280	COG0439	Biotin carboxylase
AORI_RS67290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AORI_RS67305	COG2855	membrane
AORI_RS67310	COG2814	Major facilitator Superfamily
AORI_RS67325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AORI_RS67325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_RS67335	COG0739	heme binding
AORI_RS67360	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AORI_RS67380	COG1793	dna ligase
AORI_RS67390	COG0477	Major facilitator Superfamily
AORI_RS67395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS67425	COG1846	Transcriptional regulator
AORI_RS67470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_RS67475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AORI_RS67485	COG2226	methyltransferase
AORI_RS67505	COG1082	Xylose isomerase domain protein TIM barrel
AORI_RS67510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_RS67520	COG0673	inositol 2-dehydrogenase activity
AORI_RS67565	COG1609	Transcriptional regulator
AORI_RS67570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_RS67575	COG1024	Enoyl-CoA hydratase
AORI_RS67610	COG0165	Argininosuccinate lyase
AORI_RS67630	COG1024	Enoyl-CoA hydratase
AORI_RS67635	COG1024	Enoyl-CoA hydratase
AORI_RS67660	COG0475	glutathione-regulated potassium exporter activity
AORI_RS67685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS67695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_RS67725	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AORI_RS67730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AORI_RS67790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AORI_RS67795	COG1522	sequence-specific DNA binding
AORI_RS67815	COG0475	glutathione-regulated potassium exporter activity
AORI_RS67820	COG3033	Beta-eliminating lyase
AORI_RS67830	COG0596	Alpha beta hydrolase
AORI_RS67840	COG0484	heat shock protein binding
AORI_RS67860	COG0477	Major facilitator Superfamily
AORI_RS67865	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS67875	COG4221	oxidoreductase activity
AORI_RS67880	COG1309	transcriptional regulator
AORI_RS67890	COG2986	histidine ammonia-lyase
AORI_RS67900	COG0667	Aldo Keto reductase
AORI_RS67930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_RS67960	COG0367	asparagine synthase
AORI_RS67995	COG0300	oxidoreductase activity
AORI_RS68000	COG0667	Aldo Keto reductase
AORI_RS68005	COG2124	cytochrome p450
AORI_RS68010	COG2197	response regulator
AORI_RS68040	COG0791	NLP P60 protein
AORI_RS68040	COG3883	PFAM NLP P60 protein
AORI_RS68060	COG1063	alcohol dehydrogenase
AORI_RS68075	COG2132	Multicopper oxidase
AORI_RS68165	COG1278	Cold shock
AORI_RS68180	COG2197	response regulator
AORI_RS68185	COG0604	alcohol dehydrogenase
AORI_RS68185	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS68185	COG3321	synthase
AORI_RS68190	COG3321	synthase
AORI_RS68190	COG0604	alcohol dehydrogenase
AORI_RS68190	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS68200	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS68215	COG2986	histidine ammonia-lyase
AORI_RS68225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AORI_RS68230	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS68235	COG0006	proline dipeptidase activity
AORI_RS68265	COG1674	ftsk spoiiie
AORI_RS68270	COG1404	Belongs to the peptidase S8 family
AORI_RS68300	COG0464	growth
AORI_RS68325	COG1113	amino acid transport
AORI_RS68330	COG2197	response regulator
AORI_RS68350	COG3903	Transcriptional regulator
AORI_RS68350	COG3629	intracellular signal transduction
AORI_RS68355	COG3903	Transcriptional regulator
AORI_RS68355	COG3629	intracellular signal transduction
AORI_RS68370	COG1175	transmembrane transport
AORI_RS68380	COG2197	response regulator
AORI_RS68395	COG1063	alcohol dehydrogenase
AORI_RS68415	COG3903	Transcriptional regulator
AORI_RS68415	COG3629	intracellular signal transduction
AORI_RS68460	COG0076	glutamate decarboxylase activity
AORI_RS68500	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS68520	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS68525	COG2124	cytochrome p450
AORI_RS68545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AORI_RS68575	COG3285	dna ligase
AORI_RS68575	COG1793	dna ligase
AORI_RS68585	COG1733	regulation of RNA biosynthetic process
AORI_RS68595	COG1785	Belongs to the alkaline phosphatase family
AORI_RS68600	COG2197	response regulator
AORI_RS68605	COG4585	Histidine kinase
AORI_RS68615	COG1302	Protein conserved in bacteria
AORI_RS68650	COG1595	DNA-templated transcription, initiation
AORI_RS68665	COG3237	CsbD-like
AORI_RS68670	COG0596	Alpha beta hydrolase
AORI_RS68680	COG1280	lysine exporter protein (LysE YggA)
AORI_RS68690	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AORI_RS68700	COG3903	Transcriptional regulator
AORI_RS68700	COG3629	intracellular signal transduction
AORI_RS68720	COG0789	Transcriptional regulator
AORI_RS68735	COG0640	Transcriptional regulator
AORI_RS68750	COG0596	Alpha beta hydrolase
AORI_RS68755	COG0494	nUDIX hydrolase
AORI_RS68775	COG0142	geranyltranstransferase activity
AORI_RS68810	COG0640	Transcriptional regulator
AORI_RS68815	COG0514	ATP-dependent DNA helicase (RecQ)
AORI_RS68825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AORI_RS68845	COG0542	response to heat
AORI_RS68850	COG0477	Major facilitator Superfamily
AORI_RS68860	COG0667	Aldo Keto reductase
AORI_RS68870	COG0667	Aldo Keto reductase
AORI_RS68885	COG2010	Cytochrome c
AORI_RS68885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AORI_RS68900	COG1940	carbohydrate kinase activity
AORI_RS68915	COG1309	transcriptional regulator
AORI_RS68935	COG0248	Ppx GppA phosphatase
AORI_RS68940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS68960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AORI_RS68970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AORI_RS68985	COG0640	Transcriptional regulator
AORI_RS68995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AORI_RS69020	COG3599	regulation of cell shape
AORI_RS69030	COG1799	cell septum assembly
AORI_RS69035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AORI_RS69040	COG1496	oxidoreductase activity
AORI_RS69055	COG1595	DNA-templated transcription, initiation
AORI_RS69070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AORI_RS69080	COG2318	DinB family
AORI_RS69090	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AORI_RS69110	COG0067	glutamate synthase
AORI_RS69110	COG0070	glutamate synthase
AORI_RS69110	COG0069	glutamate synthase activity
AORI_RS69130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AORI_RS69135	COG1473	amidohydrolase
AORI_RS69145	COG0174	glutamine synthetase
AORI_RS69150	COG0159	tryptophan synthase activity
AORI_RS69155	COG0133	tryptophan synthase activity
AORI_RS69160	COG0134	indole-3-glycerol-phosphate synthase activity
AORI_RS69170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AORI_RS69190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AORI_RS69200	COG0107	imidazoleglycerol-phosphate synthase activity
AORI_RS69205	COG1309	transcriptional regulator
AORI_RS69255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AORI_RS69260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AORI_RS69270	COG1960	acyl-CoA dehydrogenase activity
AORI_RS69285	COG3958	Transketolase
AORI_RS69290	COG3959	Transketolase, thiamine diphosphate binding domain
AORI_RS69300	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AORI_RS69310	COG1309	transcriptional regulator
AORI_RS69315	COG2409	Drug exporters of the RND superfamily
AORI_RS69340	COG0131	Imidazoleglycerol-phosphate dehydratase
AORI_RS69345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AORI_RS69350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AORI_RS69365	COG3386	PFAM SMP-30 Gluconolaconase
AORI_RS69370	COG2197	response regulator
AORI_RS69420	COG1674	ftsk spoiiie
AORI_RS69430	COG3896	Chloramphenicol phosphotransferase-like protein
AORI_RS69475	COG1404	Belongs to the peptidase S8 family
AORI_RS69485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AORI_RS69490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AORI_RS69500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AORI_RS69520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AORI_RS69525	COG0659	secondary active sulfate transmembrane transporter activity
AORI_RS69530	COG0659	secondary active sulfate transmembrane transporter activity
AORI_RS69535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AORI_RS69540	COG2124	cytochrome p450
AORI_RS69555	COG0438	transferase activity, transferring glycosyl groups
AORI_RS69615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AORI_RS69625	COG2010	Cytochrome c
AORI_RS69630	COG1845	cytochrome c oxidase, subunit III
AORI_RS69665	COG0697	spore germination
AORI_RS69675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AORI_RS69690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AORI_RS69710	COG0667	Aldo Keto reductase
AORI_RS69720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AORI_RS69735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AORI_RS69745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AORI_RS69765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AORI_RS69780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AORI_RS69785	COG0508	dehydrogenase complex catalyzes the overall conversion of
AORI_RS69800	COG1090	epimerase
AORI_RS69810	COG0321	lipoyl(octanoyl) transferase activity
AORI_RS69825	COG1309	transcriptional regulator
AORI_RS69840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AORI_RS69845	COG0586	Pfam SNARE associated Golgi protein
AORI_RS69850	COG1752	Esterase of the alpha-beta hydrolase superfamily
AORI_RS69855	COG1376	ErfK ybiS ycfS ynhG family protein
AORI_RS69860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AORI_RS69885	COG0477	Major facilitator Superfamily
AORI_RS69890	COG0587	DNA-directed DNA polymerase activity
AORI_RS69915	COG1113	amino acid transport
AORI_RS69960	COG3226	Transcriptional regulator
AORI_RS69965	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS70010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AORI_RS70020	COG3201	nicotinamide mononucleotide transporter
AORI_RS70025	COG0668	transmembrane transport
AORI_RS70035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AORI_RS70040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AORI_RS70055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AORI_RS70080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AORI_RS70090	COG0095	Lipoate-protein ligase
AORI_RS70100	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AORI_RS70135	COG2197	response regulator
AORI_RS70150	COG1396	sequence-specific DNA binding
AORI_RS70185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AORI_RS70195	COG0442	prolyl-tRNA aminoacylation
AORI_RS70215	COG0456	acetyltransferase
AORI_RS70220	COG3022	response to hydroperoxide
AORI_RS70240	COG1404	Belongs to the peptidase S8 family
AORI_RS70255	COG0513	Belongs to the DEAD box helicase family
AORI_RS70260	COG0156	8-amino-7-oxononanoate synthase activity
AORI_RS70290	COG2807	transmembrane transport
AORI_RS70295	COG2186	Transcriptional regulator
AORI_RS70305	COG0768	penicillin binding
AORI_RS70310	COG0456	acetyltransferase
AORI_RS70310	COG0454	-acetyltransferase
AORI_RS70315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AORI_RS70320	COG0750	zinc metalloprotease
AORI_RS70325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AORI_RS70340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AORI_RS70370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AORI_RS70370	COG2755	lipolytic protein G-D-S-L family
AORI_RS70380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS70390	COG2124	cytochrome p450
AORI_RS70415	COG1476	TRANSCRIPTIONal
AORI_RS70420	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS70420	COG3321	synthase
AORI_RS70420	COG0604	alcohol dehydrogenase
AORI_RS70425	COG3540	Alkaline phosphatase
AORI_RS70505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AORI_RS70510	COG1695	Transcriptional regulator
AORI_RS70540	COG0528	UMP kinase activity
AORI_RS70545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AORI_RS70550	COG0052	Belongs to the universal ribosomal protein uS2 family
AORI_RS70560	COG1191	sigma factor activity
AORI_RS70580	COG0792	nuclease activity
AORI_RS70590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AORI_RS70595	COG0681	Belongs to the peptidase S26 family
AORI_RS70600	COG0335	large ribosomal subunit rRNA binding
AORI_RS70605	COG0336	Belongs to the RNA methyltransferase TrmD family
AORI_RS70620	COG0228	four-way junction DNA binding
AORI_RS70650	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AORI_RS70660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AORI_RS70715	COG2873	o-acetylhomoserine
AORI_RS70720	COG1832	CoA-binding protein
AORI_RS70725	COG4266	Belongs to the allantoicase family
AORI_RS70730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AORI_RS70745	COG2351	hydroxyisourate hydrolase activity
AORI_RS70760	COG1309	transcriptional regulator
AORI_RS70775	COG2252	PERMEase
AORI_RS70780	COG0590	tRNA wobble adenosine to inosine editing
AORI_RS70785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AORI_RS70805	COG3835	regulator
AORI_RS70845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AORI_RS70850	COG1414	Transcriptional regulator
AORI_RS70860	COG0477	Major facilitator Superfamily
AORI_RS70875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AORI_RS70890	COG1254	Belongs to the acylphosphatase family
AORI_RS70910	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AORI_RS70915	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AORI_RS70920	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AORI_RS70930	COG0367	asparagine synthase
AORI_RS70945	COG1131	(ABC) transporter
AORI_RS70950	COG1725	Transcriptional regulator
AORI_RS70955	COG3903	Transcriptional regulator
AORI_RS70955	COG3629	intracellular signal transduction
AORI_RS70965	COG0673	inositol 2-dehydrogenase activity
AORI_RS70970	COG1609	Transcriptional regulator
AORI_RS70975	COG1082	Xylose isomerase domain protein TIM barrel
AORI_RS70995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AORI_RS71000	COG3718	enzyme involved in inositol metabolism
AORI_RS71005	COG3962	Belongs to the TPP enzyme family
AORI_RS71065	COG1522	sequence-specific DNA binding
AORI_RS71090	COG0667	Aldo Keto reductase
AORI_RS71105	COG1414	Transcriptional regulator
AORI_RS71110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_RS71115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AORI_RS71120	COG3485	protocatechuate 3,4-dioxygenase
AORI_RS71125	COG3485	protocatechuate 3,4-dioxygenase
AORI_RS71135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AORI_RS71140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AORI_RS71170	COG1929	Belongs to the glycerate kinase type-1 family
AORI_RS71190	COG2149	membrane
AORI_RS71220	COG2186	Transcriptional regulator
AORI_RS71225	COG1172	Belongs to the binding-protein-dependent transport system permease family
AORI_RS71230	COG1129	ABC transporter
AORI_RS71245	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_RS71250	COG0179	Fumarylacetoacetate (FAA) hydrolase
AORI_RS71255	COG2814	Major facilitator Superfamily
AORI_RS71270	COG4221	oxidoreductase activity
AORI_RS71280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS71285	COG1120	ATPase activity
AORI_RS71290	COG4122	O-methyltransferase activity
AORI_RS71295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AORI_RS71305	COG2186	Transcriptional regulator
AORI_RS71310	COG1760	l-serine dehydratase
AORI_RS71315	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AORI_RS71320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AORI_RS71325	COG0509	glycine decarboxylation via glycine cleavage system
AORI_RS71330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AORI_RS71335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AORI_RS71335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AORI_RS71350	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS71355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AORI_RS71360	COG0174	glutamine synthetase
AORI_RS71370	COG0017	Asparaginyl-tRNA synthetase
AORI_RS71385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS71420	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AORI_RS71430	COG0571	ribonuclease III activity
AORI_RS71435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AORI_RS71465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AORI_RS71470	COG0742	ribosomal rna small subunit methyltransferase
AORI_RS71475	COG3973	AAA domain
AORI_RS71480	COG2319	Wd-40 repeat
AORI_RS71480	COG4249	Peptidase C14 caspase catalytic subunit p20
AORI_RS71485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS71495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AORI_RS71520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AORI_RS71575	COG1404	Belongs to the peptidase S8 family
AORI_RS71615	COG1461	Dihydroxyacetone kinase
AORI_RS71620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AORI_RS71625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AORI_RS71630	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AORI_RS71665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS71675	COG2205	protein histidine kinase activity
AORI_RS71680	COG0745	RESPONSE REGULATOR receiver
AORI_RS71705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_RS71720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AORI_RS71730	COG1920	GTP binding
AORI_RS71740	COG0406	alpha-ribazole phosphatase activity
AORI_RS71740	COG0494	nUDIX hydrolase
AORI_RS71745	COG0776	regulation of translation
AORI_RS71750	COG0066	3-isopropylmalate dehydratase activity
AORI_RS71755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AORI_RS71770	COG0745	RESPONSE REGULATOR receiver
AORI_RS71775	COG0464	growth
AORI_RS71785	COG0745	RESPONSE REGULATOR receiver
AORI_RS71790	COG2205	protein histidine kinase activity
AORI_RS71840	COG1674	ftsk spoiiie
AORI_RS71895	COG0714	Associated with various cellular activities
AORI_RS71955	COG1982	Orn Lys Arg decarboxylase major
AORI_RS71980	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AORI_RS71995	COG0534	Mate efflux family protein
AORI_RS72000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AORI_RS72005	COG0019	diaminopimelate decarboxylase activity
AORI_RS72020	COG0583	DNA-binding transcription factor activity
AORI_RS72065	COG0640	Transcriptional regulator
AORI_RS72080	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS72105	COG1414	Transcriptional regulator
AORI_RS72135	COG0179	Fumarylacetoacetate (FAA) hydrolase
AORI_RS72140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AORI_RS72145	COG0473	3-isopropylmalate dehydrogenase activity
AORI_RS72150	COG1404	Belongs to the peptidase S8 family
AORI_RS72200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AORI_RS72205	COG0440	acetolactate synthase activity
AORI_RS72220	COG0129	dihydroxy-acid dehydratase activity
AORI_RS72265	COG0154	amidase activity
AORI_RS72270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AORI_RS72285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AORI_RS72305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_RS72310	COG0456	acetyltransferase
AORI_RS72315	COG0482	sulfurtransferase activity
AORI_RS72350	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AORI_RS72360	COG1307	EDD domain protein, DegV family
AORI_RS72370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_RS72380	COG0386	Belongs to the glutathione peroxidase family
AORI_RS72395	COG3250	beta-galactosidase activity
AORI_RS72405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AORI_RS72420	COG0702	epimerase
AORI_RS72435	COG0110	maltose O-acetyltransferase activity
AORI_RS72440	COG1957	nucleoside hydrolase
AORI_RS72445	COG0791	NLP P60 protein
AORI_RS72445	COG3883	PFAM NLP P60 protein
AORI_RS72475	COG1252	NADH dehydrogenase
AORI_RS72480	COG1595	DNA-templated transcription, initiation
AORI_RS72495	COG2272	Belongs to the type-B carboxylesterase lipase family
AORI_RS72500	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AORI_RS72525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AORI_RS72615	COG2226	methyltransferase
AORI_RS72620	COG1024	Enoyl-CoA hydratase
AORI_RS72625	COG1119	ATPase activity
AORI_RS72665	COG0058	SHG alpha-glucan phosphorylase activity
AORI_RS72690	COG1846	Transcriptional regulator
AORI_RS72700	COG3537	Alpha-1,2-mannosidase
AORI_RS72705	COG1609	Transcriptional regulator
AORI_RS72735	COG3275	phosphorelay sensor kinase activity
AORI_RS72740	COG3279	Response regulator of the LytR AlgR family
AORI_RS72750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_RS72760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AORI_RS72770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AORI_RS72775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AORI_RS72795	COG0183	Belongs to the thiolase family
AORI_RS72800	COG0346	lactoylglutathione lyase activity
AORI_RS72830	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AORI_RS72835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AORI_RS72850	COG2226	methyltransferase
AORI_RS72860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AORI_RS72870	COG0433	COG0433 Predicted ATPase
AORI_RS72875	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AORI_RS72890	COG1376	ErfK ybiS ycfS ynhG family protein
AORI_RS72900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_RS72960	COG0489	protein tyrosine kinase activity
AORI_RS73040	COG1024	Enoyl-CoA hydratase
AORI_RS73045	COG1309	transcriptional regulator
AORI_RS73050	COG0492	ferredoxin-NADP+ reductase activity
AORI_RS73070	COG0673	inositol 2-dehydrogenase activity
AORI_RS73080	COG2814	Major facilitator Superfamily
AORI_RS73090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AORI_RS73100	COG2267	carboxylic ester hydrolase activity
AORI_RS73120	COG0698	ribose 5-phosphate isomerase
AORI_RS73130	COG3469	chitinase activity
AORI_RS73170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AORI_RS73180	COG1408	metallophosphoesterase
AORI_RS73215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_RS73225	COG2259	Doxx family
AORI_RS73230	COG2259	Doxx family
AORI_RS73245	COG2018	Roadblock/LC7 domain
AORI_RS73260	COG3844	kynureninase activity
AORI_RS73275	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS73285	COG3706	GGDEF domain
AORI_RS73295	COG1316	TRANSCRIPTIONal
AORI_RS73410	COG0587	DNA-directed DNA polymerase activity
AORI_RS73455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AORI_RS73460	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AORI_RS73470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AORI_RS73485	COG1794	racemase activity, acting on amino acids and derivatives
AORI_RS73505	COG3191	aminopeptidase activity
AORI_RS73520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AORI_RS73525	COG1335	isochorismatase
AORI_RS73530	COG0800	Aldolase
AORI_RS73570	COG3830	Belongs to the UPF0237 family
AORI_RS73570	COG0560	Phosphoserine phosphatase
AORI_RS73575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AORI_RS73585	COG1819	glycosyl
AORI_RS73590	COG2267	carboxylic ester hydrolase activity
AORI_RS73610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AORI_RS73630	COG0668	transmembrane transport
AORI_RS73640	COG0626	cystathionine gamma-synthase activity
AORI_RS73645	COG1522	sequence-specific DNA binding
AORI_RS73660	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_RS73670	COG1461	Dihydroxyacetone kinase
AORI_RS73675	COG2376	Dihydroxyacetone kinase
AORI_RS73715	COG1752	Esterase of the alpha-beta hydrolase superfamily
AORI_RS73720	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AORI_RS73735	COG4977	sequence-specific DNA binding
AORI_RS73745	COG1126	abc transporter atp-binding protein
AORI_RS73750	COG0765	amino acid transport
AORI_RS73755	COG0765	amino acid transport
AORI_RS73760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_RS73765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AORI_RS73765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AORI_RS73780	COG1280	lysine exporter protein (LysE YggA)
AORI_RS73810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AORI_RS73820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AORI_RS73825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AORI_RS73830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AORI_RS73835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AORI_RS73840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AORI_RS73845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AORI_RS73850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AORI_RS73855	COG0356	it plays a direct role in the translocation of protons across the membrane
AORI_RS73865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AORI_RS73885	COG2890	protein-(glutamine-N5) methyltransferase activity
AORI_RS73890	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AORI_RS73900	COG0596	Alpha beta hydrolase
AORI_RS73925	COG0254	rRNA binding
AORI_RS73940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AORI_RS73940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AORI_RS73945	COG0083	homoserine kinase activity
AORI_RS73950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AORI_RS73955	COG0460	homoserine dehydrogenase
AORI_RS73960	COG0019	diaminopimelate decarboxylase activity
AORI_RS73965	COG0018	arginyl-trna synthetase
AORI_RS73985	COG0596	Alpha beta hydrolase
AORI_RS74055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AORI_RS74065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AORI_RS74070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AORI_RS74080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AORI_RS74095	COG0183	Belongs to the thiolase family
AORI_RS74100	COG1960	acyl-CoA dehydrogenase activity
AORI_RS74105	COG1960	acyl-CoA dehydrogenase activity
AORI_RS74110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS74120	COG2124	cytochrome p450
AORI_RS74125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_RS74130	COG1215	transferase activity, transferring glycosyl groups
AORI_RS74135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_RS74140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_RS74150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_RS74165	COG0644	oxidoreductase
AORI_RS74170	COG0475	glutathione-regulated potassium exporter activity
AORI_RS74175	COG1960	acyl-CoA dehydrogenase activity
AORI_RS74225	COG2197	response regulator
AORI_RS74255	COG2132	Multicopper oxidase
AORI_RS74265	COG4585	Histidine kinase
AORI_RS74270	COG2197	response regulator
AORI_RS74305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AORI_RS74320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS74325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AORI_RS74335	COG1053	succinate dehydrogenase
AORI_RS74350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AORI_RS74370	COG4941	Belongs to the sigma-70 factor family
AORI_RS74385	COG1846	Transcriptional regulator
AORI_RS74400	COG2910	NAD(P)H-binding
AORI_RS74420	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS74425	COG1414	Transcriptional regulator
AORI_RS74445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AORI_RS74455	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS74485	COG0435	Glutathione S-transferase
AORI_RS74495	COG2133	pyrroloquinoline quinone binding
AORI_RS74525	COG0667	Aldo Keto reductase
AORI_RS74540	COG0154	amidase activity
AORI_RS74570	COG0473	3-isopropylmalate dehydrogenase activity
AORI_RS74580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AORI_RS74595	COG3629	intracellular signal transduction
AORI_RS74595	COG3903	Transcriptional regulator
AORI_RS74610	COG0028	Belongs to the TPP enzyme family
AORI_RS74615	COG0477	Major facilitator Superfamily
AORI_RS74640	COG4585	Histidine kinase
AORI_RS74645	COG2197	response regulator
AORI_RS74650	COG2409	Drug exporters of the RND superfamily
AORI_RS74655	COG1024	Enoyl-CoA hydratase
AORI_RS74655	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_RS74660	COG0183	Belongs to the thiolase family
AORI_RS74665	COG1309	transcriptional regulator
AORI_RS74680	COG1960	acyl-CoA dehydrogenase activity
AORI_RS74695	COG4221	oxidoreductase activity
AORI_RS74710	COG1960	acyl-CoA dehydrogenase activity
AORI_RS74720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AORI_RS74725	COG2755	lipolytic protein G-D-S-L family
AORI_RS74740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AORI_RS74750	COG0346	lactoylglutathione lyase activity
AORI_RS74755	COG1695	Transcriptional regulator
AORI_RS74765	COG2508	Transcriptional regulator
AORI_RS74765	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AORI_RS74785	COG0686	Belongs to the AlaDH PNT family
AORI_RS74790	COG3629	intracellular signal transduction
AORI_RS74790	COG3903	Transcriptional regulator
AORI_RS74825	COG1132	(ABC) transporter
AORI_RS74845	COG0508	dehydrogenase complex catalyzes the overall conversion of
AORI_RS74845	COG0567	Dehydrogenase, E1 component
AORI_RS74855	COG1404	Belongs to the peptidase S8 family
AORI_RS74860	COG3153	acetyltransferase
AORI_RS74870	COG1174	glycine betaine transport
AORI_RS74875	COG1174	glycine betaine transport
AORI_RS74880	COG1125	glycine betaine transport
AORI_RS74880	COG0517	IMP dehydrogenase activity
AORI_RS74890	COG0281	malic enzyme
AORI_RS74895	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AORI_RS74915	COG0406	alpha-ribazole phosphatase activity
AORI_RS74930	COG1597	lipid kinase activity
AORI_RS74955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AORI_RS74970	COG2135	peptidase activity
AORI_RS74975	COG1162	GTPase activity
AORI_RS75000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AORI_RS75015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AORI_RS75020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_RS75030	COG0653	protein targeting
AORI_RS75035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AORI_RS75050	COG5000	phosphorelay sensor kinase activity
AORI_RS75050	COG5002	protein histidine kinase activity
AORI_RS75055	COG0745	RESPONSE REGULATOR receiver
AORI_RS75060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AORI_RS75065	COG2146	nitrite reductase [NAD(P)H] activity
AORI_RS75080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_RS75085	COG4638	Rieske (2fe-2S)
AORI_RS75110	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AORI_RS75125	COG0531	amino acid
AORI_RS75135	COG3629	intracellular signal transduction
AORI_RS75135	COG3903	Transcriptional regulator
AORI_RS75145	COG1482	cell wall glycoprotein biosynthetic process
AORI_RS75155	COG2835	tetraacyldisaccharide 4'-kinase activity
AORI_RS75160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AORI_RS75185	COG1994	Peptidase M50
AORI_RS75200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AORI_RS75215	COG0601	transmembrane transport
AORI_RS75225	COG0747	negative chemotaxis
AORI_RS75230	COG2826	transposase and inactivated derivatives, IS30 family
AORI_RS75235	COG1217	gtp-binding protein TYPA
AORI_RS75245	COG0180	Tryptophanyl-tRNA synthetase
AORI_RS75255	COG2205	protein histidine kinase activity
AORI_RS75270	COG1131	(ABC) transporter
AORI_RS75285	COG3842	ATPase activity
AORI_RS75290	COG4149	molybdate abc transporter
AORI_RS75300	COG2154	pterin-4-alpha-carbinolamine dehydratase
AORI_RS75310	COG3654	unkown
AORI_RS75325	COG2234	aminopeptidase activity
AORI_RS75365	COG0012	GTP binding
AORI_RS75380	COG0419	ATPase involved in DNA repair
AORI_RS75385	COG0420	3'-5' exonuclease activity
AORI_RS75400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AORI_RS75410	COG1570	exodeoxyribonuclease VII activity
AORI_RS75420	COG1722	exodeoxyribonuclease VII activity
AORI_RS75435	COG0492	ferredoxin-NADP+ reductase activity
AORI_RS75440	COG0114	fumarate hydratase activity
AORI_RS75460	COG1793	dna ligase
AORI_RS75495	COG1733	regulation of RNA biosynthetic process
AORI_RS75520	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AORI_RS75550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AORI_RS75575	COG1331	Highly conserved protein containing a thioredoxin domain
AORI_RS75585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AORI_RS75595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AORI_RS75605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AORI_RS75610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_RS75620	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AORI_RS75685	COG0183	Belongs to the thiolase family
AORI_RS75690	COG0477	Major facilitator Superfamily
AORI_RS75695	COG2391	methyltransferase activity
AORI_RS75740	COG1902	pentaerythritol trinitrate reductase activity
AORI_RS75745	COG0789	Transcriptional regulator
AORI_RS75760	COG0640	Transcriptional regulator
AORI_RS75765	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_RS75780	COG2124	cytochrome p450
AORI_RS75785	COG0406	alpha-ribazole phosphatase activity
AORI_RS75810	COG4585	Histidine kinase
AORI_RS75815	COG2197	response regulator
AORI_RS75830	COG0745	RESPONSE REGULATOR receiver
AORI_RS75925	COG1252	NADH dehydrogenase
AORI_RS75935	COG1515	deoxyribonuclease V activity
AORI_RS75950	COG1404	Belongs to the peptidase S8 family
AORI_RS75955	COG4608	Belongs to the ABC transporter superfamily
AORI_RS75960	COG0444	Belongs to the ABC transporter superfamily
AORI_RS75965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AORI_RS75970	COG0601	transmembrane transport
AORI_RS75975	COG4166	transmembrane transport
AORI_RS76000	COG0148	phosphopyruvate hydratase activity
AORI_RS76045	COG1131	(ABC) transporter
AORI_RS76055	COG1595	DNA-templated transcription, initiation
AORI_RS76075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS76085	COG0586	Pfam SNARE associated Golgi protein
AORI_RS76095	COG4585	Histidine kinase
AORI_RS76100	COG2197	response regulator
AORI_RS76105	COG2133	pyrroloquinoline quinone binding
AORI_RS76115	COG1335	isochorismatase
AORI_RS76150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AORI_RS76180	COG0193	aminoacyl-tRNA hydrolase activity
AORI_RS76195	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS76200	COG0488	(ABC) transporter
AORI_RS76205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AORI_RS76210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AORI_RS76215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AORI_RS76235	COG0084	hydrolase, TatD family'
AORI_RS76240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AORI_RS76320	COG2258	MOSC domain
AORI_RS76335	COG1012	belongs to the aldehyde dehydrogenase family
AORI_RS76350	COG1309	transcriptional regulator
AORI_RS76385	COG2409	Drug exporters of the RND superfamily
AORI_RS76390	COG2226	methyltransferase
AORI_RS76400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AORI_RS76410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_RS76485	COG0521	Mo-molybdopterin cofactor biosynthetic process
AORI_RS76485	COG0315	cyclic pyranopterin monophosphate synthase activity
AORI_RS76490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AORI_RS76505	COG5002	protein histidine kinase activity
AORI_RS76510	COG0745	RESPONSE REGULATOR receiver
AORI_RS76545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AORI_RS76550	COG1349	DNA-binding transcription factor activity
AORI_RS76560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AORI_RS76570	COG2205	protein histidine kinase activity
AORI_RS76575	COG0745	RESPONSE REGULATOR receiver
AORI_RS76580	COG2860	membrane
AORI_RS76585	COG2197	response regulator
AORI_RS76635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AORI_RS76645	COG1396	sequence-specific DNA binding
AORI_RS76675	COG3629	intracellular signal transduction
AORI_RS76675	COG3903	Transcriptional regulator
AORI_RS76725	COG4941	Belongs to the sigma-70 factor family
AORI_RS76740	COG0702	epimerase
AORI_RS76745	COG2264	protein methyltransferase activity
AORI_RS76750	COG0583	DNA-binding transcription factor activity
AORI_RS76760	COG2755	lipolytic protein G-D-S-L family
AORI_RS76760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AORI_RS76810	COG1940	carbohydrate kinase activity
AORI_RS76825	COG2814	Major facilitator Superfamily
AORI_RS76835	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AORI_RS76840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AORI_RS76845	COG1984	allophanate hydrolase subunit 2
AORI_RS76865	COG1321	iron dependent repressor
AORI_RS76875	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AORI_RS76880	COG1024	Enoyl-CoA hydratase
AORI_RS76885	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS76900	COG1960	acyl-CoA dehydrogenase activity
AORI_RS76905	COG1301	dicarboxylic acid transport
AORI_RS76915	COG1169	isochorismate synthase
AORI_RS76970	COG0277	FAD linked oxidase domain protein
AORI_RS77005	COG4152	abc transporter atp-binding protein
AORI_RS77010	COG1668	transmembrane transport
AORI_RS77015	COG0415	Belongs to the DNA photolyase family
AORI_RS77035	COG1960	acyl-CoA dehydrogenase activity
AORI_RS77050	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AORI_RS77060	COG2017	converts alpha-aldose to the beta-anomer
AORI_RS77065	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS77075	COG1309	transcriptional regulator
AORI_RS77105	COG0259	pyridoxamine-phosphate oxidase activity
AORI_RS77120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AORI_RS77125	COG1116	anion transmembrane transporter activity
AORI_RS77130	COG0642	Histidine kinase
AORI_RS77160	COG0829	nickel cation binding
AORI_RS77165	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AORI_RS77175	COG0804	urea catabolic process
AORI_RS77180	COG0832	Belongs to the urease beta subunit family
AORI_RS77185	COG0831	urea catabolic process
AORI_RS77225	COG1131	(ABC) transporter
AORI_RS77235	COG4585	Histidine kinase
AORI_RS77240	COG2197	response regulator
AORI_RS77245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_RS77265	COG5650	phosphatidylinositol metabolic process
AORI_RS77270	COG1136	(ABC) transporter
AORI_RS77270	COG0577	efflux transmembrane transporter activity
AORI_RS77275	COG0577	efflux transmembrane transporter activity
AORI_RS77275	COG1136	(ABC) transporter
AORI_RS77290	COG5183	chlorophyll binding
AORI_RS77290	COG2133	pyrroloquinoline quinone binding
AORI_RS77295	COG0745	RESPONSE REGULATOR receiver
AORI_RS77300	COG2205	protein histidine kinase activity
AORI_RS77325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AORI_RS77370	COG2814	Major facilitator Superfamily
AORI_RS77380	COG2252	PERMEase
AORI_RS77405	COG2814	Major facilitator Superfamily
AORI_RS77415	COG1278	Cold shock
AORI_RS77435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AORI_RS77450	COG0318	PFAM AMP-dependent synthetase and ligase
AORI_RS77455	COG0384	phenazine biosynthesis protein PhzF
AORI_RS77460	COG3304	Inner membrane component domain
AORI_RS77495	COG1846	Transcriptional regulator
AORI_RS77515	COG1388	LysM domain
AORI_RS77525	COG0521	Mo-molybdopterin cofactor biosynthetic process
AORI_RS77565	COG2018	Roadblock/LC7 domain
AORI_RS77580	COG2018	Roadblock/LC7 domain
AORI_RS77600	COG1174	glycine betaine transport
AORI_RS77605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AORI_RS77610	COG1116	anion transmembrane transporter activity
AORI_RS77610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AORI_RS77640	COG1061	Type III restriction enzyme res subunit
AORI_RS77655	COG3903	Transcriptional regulator
AORI_RS77655	COG3629	intracellular signal transduction
AORI_RS77660	COG4948	Mandelate Racemase Muconate Lactonizing
AORI_RS77695	COG0459	protein refolding
AORI_RS77705	COG1278	Cold shock
AORI_RS77735	COG2261	transglycosylase associated protein
AORI_RS77740	COG0688	phosphatidylethanolamine metabolic process
AORI_RS77760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AORI_RS77775	COG0242	peptide deformylase activity
AORI_RS77785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AORI_RS77790	COG0351	phosphomethylpyrimidine kinase
AORI_RS77800	COG1733	regulation of RNA biosynthetic process
AORI_RS77825	COG2022	thiamine diphosphate biosynthetic process
AORI_RS77835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AORI_RS77835	COG2022	thiamine diphosphate biosynthetic process
AORI_RS77840	COG0352	thiamine-phosphate diphosphorylase activity
AORI_RS77855	COG0477	Major facilitator Superfamily
AORI_RS77860	COG2188	Transcriptional regulator
AORI_RS77865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AORI_RS77870	COG2971	BadF BadG BcrA BcrD
AORI_RS77910	COG3903	Transcriptional regulator
AORI_RS77910	COG3629	intracellular signal transduction
AORI_RS77915	COG5285	phytanoyl-CoA dioxygenase
AORI_RS77920	COG1917	Cupin 2, conserved barrel domain protein
AORI_RS77930	COG0456	acetyltransferase
AORI_RS77935	COG1752	Esterase of the alpha-beta hydrolase superfamily
AORI_RS77940	COG4399	Belongs to the UPF0754 family
AORI_RS77965	COG5416	Lipopolysaccharide assembly protein A domain
AORI_RS77975	COG0400	carboxylic ester hydrolase activity
AORI_RS77980	COG0346	lactoylglutathione lyase activity
AORI_RS77990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_RS78025	COG3971	2-oxopent-4-enoate hydratase activity
AORI_RS78035	COG1832	CoA-binding protein
AORI_RS78045	COG1620	l-lactate permease
AORI_RS78060	COG4941	Belongs to the sigma-70 factor family
AORI_RS78065	COG3795	YCII-related domain
AORI_RS78075	COG0583	DNA-binding transcription factor activity
AORI_RS78110	COG0640	Transcriptional regulator
AORI_RS78150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AORI_RS78185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AORI_RS78195	COG1329	Transcriptional regulator
AORI_RS78200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AORI_RS78205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AORI_RS78225	COG0215	cysteine-tRNA ligase activity
AORI_RS78255	COG1309	transcriptional regulator
AORI_RS78285	COG0235	Class ii aldolase
AORI_RS78300	COG0698	ribose 5-phosphate isomerase
AORI_RS78305	COG2376	Dihydroxyacetone kinase
AORI_RS78310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_RS78320	COG1349	DNA-binding transcription factor activity
AORI_RS78325	COG2814	Major facilitator Superfamily
AORI_RS78330	COG1070	Carbohydrate kinase
AORI_RS78345	COG4399	Belongs to the UPF0754 family
AORI_RS78350	COG4399	Belongs to the UPF0754 family
AORI_RS78365	COG1120	ATPase activity
AORI_RS78370	COG0803	Belongs to the bacterial solute-binding protein 9 family
AORI_RS78375	COG1609	Transcriptional regulator
AORI_RS78385	COG1194	a g-specific adenine glycosylase
AORI_RS78410	COG1953	Uracil, thiamine, allantoin
AORI_RS78430	COG3118	belongs to the thioredoxin family
AORI_RS78435	COG0596	Alpha beta hydrolase
AORI_RS78455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AORI_RS78485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AORI_RS78490	COG0443	Heat shock 70 kDa protein
AORI_RS78495	COG1396	sequence-specific DNA binding
AORI_RS78500	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AORI_RS78540	COG2226	methyltransferase
AORI_RS78545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AORI_RS78550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AORI_RS78555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AORI_RS78580	COG0789	Transcriptional regulator
AORI_RS78595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AORI_RS78600	COG0302	gtp cyclohydrolase
AORI_RS78605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AORI_RS78635	COG0037	tRNA processing
AORI_RS78645	COG2027	D-alanyl-D-alanine carboxypeptidase
AORI_RS78650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AORI_RS78655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AORI_RS78665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AORI_RS78685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AORI_RS78690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AORI_RS78710	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS78715	COG0657	acetylesterase activity
AORI_RS78750	COG1660	Displays ATPase and GTPase activities
AORI_RS78815	COG0270	DNA (cytosine-5-)-methyltransferase activity
AORI_RS78845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AORI_RS78850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AORI_RS78880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AORI_RS78880	COG1754	DNA topoisomerase type I activity
AORI_RS78905	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AORI_RS78910	COG1111	helicase
AORI_RS78910	COG1205	dead DEAH box helicase
AORI_RS78960	COG1472	Belongs to the glycosyl hydrolase 3 family
AORI_RS78965	COG3876	Protein conserved in bacteria
AORI_RS78970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AORI_RS78975	COG1737	Transcriptional regulator
AORI_RS78980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AORI_RS78985	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AORI_RS78990	COG2814	Major facilitator Superfamily
AORI_RS78995	COG0640	Transcriptional regulator
AORI_RS79025	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS79035	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AORI_RS79045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AORI_RS79085	COG3104	oligopeptide transport
AORI_RS79090	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AORI_RS79100	COG0596	Alpha beta hydrolase
AORI_RS79115	COG0494	nUDIX hydrolase
AORI_RS79120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AORI_RS79155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AORI_RS79205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AORI_RS79210	COG1408	metallophosphoesterase
AORI_RS79220	COG2226	methyltransferase
AORI_RS79240	COG0076	glutamate decarboxylase activity
AORI_RS79245	COG0783	Belongs to the Dps family
AORI_RS79250	COG1764	response to oxidative stress
AORI_RS79285	COG1690	Belongs to the RtcB family
AORI_RS79290	COG0501	Belongs to the peptidase M48B family
AORI_RS79345	COG2201	protein-glutamate methylesterase activity
AORI_RS79370	COG0583	DNA-binding transcription factor activity
AORI_RS79375	COG0697	spore germination
AORI_RS79385	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS79400	COG4608	Belongs to the ABC transporter superfamily
AORI_RS79405	COG0444	Belongs to the ABC transporter superfamily
AORI_RS79410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AORI_RS79415	COG0601	transmembrane transport
AORI_RS79420	COG0747	negative chemotaxis
AORI_RS79425	COG0529	Catalyzes the synthesis of activated sulfate
AORI_RS79425	COG2046	Belongs to the sulfate adenylyltransferase family
AORI_RS79435	COG1216	Glycosyl transferase, family 2
AORI_RS79450	COG0463	Glycosyl transferase, family 2
AORI_RS79455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AORI_RS79460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AORI_RS79465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AORI_RS79470	COG0860	N-Acetylmuramoyl-L-alanine amidase
AORI_RS79500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AORI_RS79505	COG2205	protein histidine kinase activity
AORI_RS79510	COG0745	RESPONSE REGULATOR receiver
AORI_RS79525	COG4585	Histidine kinase
AORI_RS79530	COG2197	response regulator
AORI_RS79560	COG1250	3-hydroxyacyl-CoA dehydrogenase
AORI_RS79565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AORI_RS79565	COG5479	isomerase activity
AORI_RS79570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AORI_RS79570	COG5479	isomerase activity
AORI_RS79635	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
AORI_RS79665	COG1473	amidohydrolase
AORI_RS79670	COG4702	Belongs to the UPF0303 family
AORI_RS79675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_RS79690	COG3973	AAA domain
AORI_RS79750	COG0596	Alpha beta hydrolase
AORI_RS79755	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AORI_RS79770	COG0704	Plays a role in the regulation of phosphate uptake
AORI_RS79775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AORI_RS79800	COG0745	RESPONSE REGULATOR receiver
AORI_RS79830	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AORI_RS79835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AORI_RS79840	COG1984	allophanate hydrolase subunit 2
AORI_RS79860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AORI_RS79890	COG1569	PIN domain
AORI_RS79895	COG3311	Transcriptional regulator
AORI_RS79915	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AORI_RS79920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AORI_RS79990	COG1132	(ABC) transporter
AORI_RS79995	COG1132	(ABC) transporter
AORI_RS80000	COG0047	phosphoribosylformylglycinamidine synthase activity
AORI_RS80005	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AORI_RS80035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AORI_RS80040	COG2311	Membrane
AORI_RS80055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AORI_RS80065	COG1126	abc transporter atp-binding protein
AORI_RS80070	COG0765	amino acid transport
AORI_RS80075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_RS80080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AORI_RS80090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AORI_RS80135	COG5280	Phage tail tape measure protein TP901
AORI_RS80135	COG3953	SLT domain
AORI_RS80170	COG0584	glycerophosphoryl diester phosphodiesterase
AORI_RS80180	COG2814	Major facilitator Superfamily
AORI_RS80185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS80195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AORI_RS80220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AORI_RS80225	COG4172	Belongs to the ABC transporter superfamily
AORI_RS80230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS80245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS80295	COG0667	Aldo Keto reductase
AORI_RS80300	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS80345	COG0586	Pfam SNARE associated Golgi protein
AORI_RS80350	COG0277	FAD linked oxidase domain protein
AORI_RS80355	COG0477	Major facilitator Superfamily
AORI_RS80365	COG3467	pyridoxamine 5'-phosphate
AORI_RS80375	COG0477	Major facilitator Superfamily
AORI_RS80380	COG0586	Pfam SNARE associated Golgi protein
AORI_RS80390	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS80395	COG1072	(Pantothenic acid kinase))
AORI_RS80400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AORI_RS80420	COG1609	Transcriptional regulator
AORI_RS80425	COG1609	Transcriptional regulator
AORI_RS80440	COG0243	molybdopterin cofactor binding
AORI_RS80445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AORI_RS80465	COG0577	efflux transmembrane transporter activity
AORI_RS80465	COG1136	(ABC) transporter
AORI_RS80475	COG1285	pathogenesis
AORI_RS80495	COG0542	response to heat
AORI_RS80530	COG0789	Transcriptional regulator
AORI_RS80535	COG0484	heat shock protein binding
AORI_RS80540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AORI_RS80545	COG0443	Heat shock 70 kDa protein
AORI_RS80580	COG2076	Multidrug Resistance protein
AORI_RS80585	COG0247	lactate metabolic process
AORI_RS80585	COG2181	nitrate reductase activity
AORI_RS80600	COG2340	Cysteine-rich secretory protein family
AORI_RS80605	COG1846	Transcriptional regulator
AORI_RS80610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AORI_RS80615	COG0717	Belongs to the dCTP deaminase family
AORI_RS80630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AORI_RS80660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AORI_RS80670	COG4085	toxin activity
AORI_RS80670	COG0737	Belongs to the 5'-nucleotidase family
AORI_RS80670	COG1525	nuclease
AORI_RS80675	COG2267	carboxylic ester hydrolase activity
AORI_RS80695	COG3663	DNA glycosylase
AORI_RS80700	COG2197	response regulator
AORI_RS80705	COG1960	acyl-CoA dehydrogenase activity
AORI_RS80730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AORI_RS80790	COG1126	abc transporter atp-binding protein
AORI_RS80795	COG0765	amino acid transport
AORI_RS80820	COG1305	Transglutaminase-like
AORI_RS80825	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS80830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AORI_RS80840	COG0596	Alpha beta hydrolase
AORI_RS80845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AORI_RS80855	COG0022	dehydrogenase e1 component
AORI_RS80860	COG0508	dehydrogenase complex catalyzes the overall conversion of
AORI_RS80880	COG3030	protein affecting phage T7 exclusion by the F plasmid
AORI_RS80900	COG1309	transcriptional regulator
AORI_RS80905	COG2030	dehydratase
AORI_RS80910	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS80915	COG0183	Belongs to the thiolase family
AORI_RS80940	COG0584	glycerophosphoryl diester phosphodiesterase
AORI_RS80945	COG0789	Transcriptional regulator
AORI_RS81010	COG1131	(ABC) transporter
AORI_RS81020	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AORI_RS81035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AORI_RS81055	COG4585	Histidine kinase
AORI_RS81060	COG2197	response regulator
AORI_RS81090	COG1131	(ABC) transporter
AORI_RS81105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AORI_RS81115	COG1136	(ABC) transporter
AORI_RS81125	COG2197	response regulator
AORI_RS81130	COG0402	S-adenosylhomocysteine deaminase activity
AORI_RS81135	COG4221	oxidoreductase activity
AORI_RS81140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AORI_RS81145	COG2226	methyltransferase
AORI_RS81165	COG2814	Major facilitator Superfamily
AORI_RS81175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AORI_RS81185	COG1695	Transcriptional regulator
AORI_RS81195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AORI_RS81200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AORI_RS81205	COG0673	inositol 2-dehydrogenase activity
AORI_RS81210	COG1940	carbohydrate kinase activity
AORI_RS81255	COG0360	Binds together with S18 to 16S ribosomal RNA
AORI_RS81265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AORI_RS81270	COG0359	binds to the 23S rRNA
AORI_RS81300	COG2267	carboxylic ester hydrolase activity
AORI_RS81340	COG3384	dioxygenase
AORI_RS81345	COG0738	Major facilitator superfamily
AORI_RS81350	COG1940	carbohydrate kinase activity
AORI_RS81350	COG1846	Transcriptional regulator
AORI_RS81375	COG2197	response regulator
AORI_RS81390	COG0477	Major facilitator Superfamily
AORI_RS81395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AORI_RS81400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AORI_RS81435	COG1028	Short-chain dehydrogenase reductase Sdr
AORI_RS81440	COG0495	leucyl-tRNA aminoacylation
AORI_RS81515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AORI_RS81525	COG4585	Histidine kinase
AORI_RS81530	COG0617	tRNA 3'-terminal CCA addition
AORI_RS81560	COG1595	DNA-templated transcription, initiation
AORI_RS81575	COG3118	belongs to the thioredoxin family
AORI_RS81575	COG0492	ferredoxin-NADP+ reductase activity
AORI_RS81580	COG0860	N-Acetylmuramoyl-L-alanine amidase
AORI_RS81580	COG3409	Peptidoglycan-binding domain 1 protein
AORI_RS81595	COG1181	Belongs to the D-alanine--D-alanine ligase family
AORI_RS81610	COG1192	Involved in chromosome partitioning
AORI_RS81615	COG0357	Ribosomal RNA small subunit methyltransferase G
AORI_RS81625	COG0706	membrane insertase activity
AORI_RS81630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AORI_RS82205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AORI_RS82345	COG4585	Histidine kinase
AORI_RS82345	COG2203	Gaf domain
AORI_RS82375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AORI_RS82385	COG2197	response regulator
AORI_RS82415	COG0604	alcohol dehydrogenase
AORI_RS82415	COG3321	synthase
AORI_RS82470	COG3629	intracellular signal transduction
AORI_RS82470	COG3903	Transcriptional regulator
AORI_RS82525	COG3903	Transcriptional regulator
AORI_RS82525	COG3629	intracellular signal transduction
AORI_RS82550	COG2814	Major facilitator Superfamily