locus-tag	class	description
CU254_RS00045	COG0287	Prephenate dehydrogenase
CU254_RS00050	COG1902	pentaerythritol trinitrate reductase activity
CU254_RS00050	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU254_RS00070	COG2197	response regulator
CU254_RS00085	COG1846	Transcriptional regulator
CU254_RS00125	COG2318	DinB family
CU254_RS00135	COG3033	Beta-eliminating lyase
CU254_RS00215	COG4941	Belongs to the sigma-70 factor family
CU254_RS00220	COG1846	Transcriptional regulator
CU254_RS00235	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS00270	COG2130	NADP-dependent
CU254_RS00275	COG0583	DNA-binding transcription factor activity
CU254_RS00325	COG2272	Belongs to the type-B carboxylesterase lipase family
CU254_RS00385	COG2175	clavaminate synthase activity
CU254_RS00415	COG0596	Alpha beta hydrolase
CU254_RS00440	COG1132	(ABC) transporter
CU254_RS00550	COG0028	Belongs to the TPP enzyme family
CU254_RS00565	COG2217	Heavy metal translocating P-type atpase
CU254_RS00570	COG3199	ATP-NAD kinase
CU254_RS00580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_RS00585	COG0515	serine threonine protein kinase
CU254_RS00605	COG1595	DNA-templated transcription, initiation
CU254_RS00620	COG1278	Cold shock
CU254_RS00660	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CU254_RS00665	COG3300	MHYT domain
CU254_RS00665	COG5001	Diguanylate cyclase
CU254_RS00685	COG2233	PERMEase
CU254_RS00690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CU254_RS00700	COG0789	Transcriptional regulator
CU254_RS00725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CU254_RS00755	COG2814	Major facilitator Superfamily
CU254_RS00760	COG1309	transcriptional regulator
CU254_RS00775	COG0154	amidase activity
CU254_RS00810	COG2318	DinB family
CU254_RS00815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CU254_RS00835	COG0542	response to heat
CU254_RS00840	COG2364	Membrane
CU254_RS00845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS00860	COG2733	membrane
CU254_RS00885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CU254_RS00910	COG2986	histidine ammonia-lyase
CU254_RS00920	COG1174	glycine betaine transport
CU254_RS00935	COG2130	NADP-dependent
CU254_RS00965	COG1064	alcohol dehydrogenase
CU254_RS00995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CU254_RS01010	COG0438	transferase activity, transferring glycosyl groups
CU254_RS01040	COG0667	Aldo Keto reductase
CU254_RS01045	COG5002	protein histidine kinase activity
CU254_RS01075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU254_RS01120	COG1595	DNA-templated transcription, initiation
CU254_RS01125	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS01145	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CU254_RS01150	COG0181	hydroxymethylbilane synthase activity
CU254_RS01155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CU254_RS01155	COG1587	Uroporphyrinogen-III synthase
CU254_RS01180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CU254_RS01185	COG1136	(ABC) transporter
CU254_RS01190	COG1136	(ABC) transporter
CU254_RS01190	COG0577	efflux transmembrane transporter activity
CU254_RS01205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CU254_RS01210	COG0406	alpha-ribazole phosphatase activity
CU254_RS01220	COG0785	Cytochrome C biogenesis protein
CU254_RS01230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU254_RS01250	COG1522	sequence-specific DNA binding
CU254_RS01260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU254_RS01275	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU254_RS01280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CU254_RS01315	COG0438	transferase activity, transferring glycosyl groups
CU254_RS01330	COG2226	methyltransferase
CU254_RS01345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU254_RS01350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU254_RS01355	COG0649	NAD binding
CU254_RS01370	COG1034	ATP synthesis coupled electron transport
CU254_RS01375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CU254_RS01380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU254_RS01385	COG0839	Belongs to the complex I subunit 6 family
CU254_RS01390	COG0713	ATP synthesis coupled electron transport
CU254_RS01395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CU254_RS01405	COG1007	ATP synthesis coupled electron transport
CU254_RS01425	COG0142	geranyltranstransferase activity
CU254_RS01435	COG1013	pyruvate-flavodoxin oxidoreductase activity
CU254_RS01440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CU254_RS01440	COG0674	pyruvate-flavodoxin oxidoreductase activity
CU254_RS01450	COG1522	sequence-specific DNA binding
CU254_RS01455	COG1834	amidinotransferase
CU254_RS01495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU254_RS01540	COG0463	Glycosyl transferase, family 2
CU254_RS01540	COG1216	Glycosyl transferase, family 2
CU254_RS01560	COG0297	glycogen (starch) synthase activity
CU254_RS01585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CU254_RS01615	COG0789	Transcriptional regulator
CU254_RS01635	COG1666	GTP binding
CU254_RS01650	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CU254_RS01655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CU254_RS01690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CU254_RS01695	COG2030	dehydratase
CU254_RS01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS01735	COG0081	regulation of translation
CU254_RS01755	COG0222	ribosome binding
CU254_RS01770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU254_RS01795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU254_RS01825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CU254_RS01890	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS01925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CU254_RS01930	COG0049	tRNA binding
CU254_RS01935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CU254_RS01945	COG0051	transcription antitermination factor activity, RNA binding
CU254_RS01950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CU254_RS01955	COG0088	Forms part of the polypeptide exit tunnel
CU254_RS01960	COG0089	rRNA binding
CU254_RS01965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CU254_RS01970	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CU254_RS01975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CU254_RS01980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CU254_RS01995	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CU254_RS02000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CU254_RS02005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CU254_RS02010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CU254_RS02020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CU254_RS02025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CU254_RS02030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CU254_RS02035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CU254_RS02040	COG1841	ribosomal large subunit assembly
CU254_RS02045	COG0200	Binds to the 23S rRNA
CU254_RS02060	COG0563	adenylate kinase activity
CU254_RS02070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CU254_RS02075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CU254_RS02080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CU254_RS02090	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CU254_RS02095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CU254_RS02100	COG0202	RNA polymerase activity
CU254_RS02105	COG0203	ribosomal protein L17
CU254_RS02110	COG0101	tRNA pseudouridine synthase activity
CU254_RS02155	COG1404	Belongs to the peptidase S8 family
CU254_RS02165	COG1674	ftsk spoiiie
CU254_RS02170	COG0443	Heat shock 70 kDa protein
CU254_RS02200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CU254_RS02205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CU254_RS02210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU254_RS02245	COG1349	DNA-binding transcription factor activity
CU254_RS02250	COG1070	Carbohydrate kinase
CU254_RS02255	COG3842	ATPase activity
CU254_RS02260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CU254_RS02270	COG0802	atpase or kinase
CU254_RS02280	COG2321	neutral zinc metallopeptidase
CU254_RS02285	COG0477	Major facilitator Superfamily
CU254_RS02290	COG0825	malonyl-CoA metabolic process
CU254_RS02290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CU254_RS02295	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS02330	COG0456	acetyltransferase
CU254_RS02335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CU254_RS02370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CU254_RS02375	COG0459	protein refolding
CU254_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS02385	COG1309	transcriptional regulator
CU254_RS02440	COG0516	GMP reductase activity
CU254_RS02455	COG0277	FAD linked oxidase domain protein
CU254_RS02465	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS02480	COG0519	Catalyzes the synthesis of GMP from XMP
CU254_RS02480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CU254_RS02520	COG0697	spore germination
CU254_RS02525	COG0583	DNA-binding transcription factor activity
CU254_RS02530	COG0515	serine threonine protein kinase
CU254_RS02535	COG0515	serine threonine protein kinase
CU254_RS02535	COG2815	serine threonine protein kinase
CU254_RS02590	COG0045	succinate-CoA ligase (ADP-forming) activity
CU254_RS02615	COG0138	bifunctional purine biosynthesis protein purh
CU254_RS02630	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS02645	COG0587	DNA-directed DNA polymerase activity
CU254_RS02665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CU254_RS02675	COG2814	Major facilitator Superfamily
CU254_RS02680	COG0640	Transcriptional regulator
CU254_RS02685	COG2814	Major facilitator Superfamily
CU254_RS02715	COG2226	methyltransferase
CU254_RS02740	COG1234	tRNA 3'-trailer cleavage
CU254_RS02760	COG0180	Tryptophanyl-tRNA synthetase
CU254_RS02775	COG1295	ribonuclease BN
CU254_RS02780	COG1686	Belongs to the peptidase S11 family
CU254_RS02800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CU254_RS02815	COG2009	succinate dehydrogenase
CU254_RS02820	COG1744	ABC transporter substrate-binding protein PnrA-like
CU254_RS02825	COG3845	ABC transporter
CU254_RS02835	COG1079	Belongs to the binding-protein-dependent transport system permease family
CU254_RS02855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CU254_RS02860	COG2271	Major facilitator Superfamily
CU254_RS02865	COG1309	transcriptional regulator
CU254_RS02900	COG1063	alcohol dehydrogenase
CU254_RS02915	COG0395	ABC-type sugar transport system, permease component
CU254_RS02920	COG3842	ATPase activity
CU254_RS02935	COG2226	methyltransferase
CU254_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS02980	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS02985	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CU254_RS03000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CU254_RS03010	COG0789	Transcriptional regulator
CU254_RS03015	COG0667	Aldo Keto reductase
CU254_RS03035	COG0475	glutathione-regulated potassium exporter activity
CU254_RS03040	COG0745	RESPONSE REGULATOR receiver
CU254_RS03055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CU254_RS03090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU254_RS03120	COG0515	serine threonine protein kinase
CU254_RS03145	COG1473	amidohydrolase
CU254_RS03145	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CU254_RS03180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CU254_RS03185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CU254_RS03190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CU254_RS03200	COG4585	Histidine kinase
CU254_RS03215	COG4770	biotin carboxylase activity
CU254_RS03260	COG1309	transcriptional regulator
CU254_RS03275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU254_RS03310	COG3511	phospholipase C
CU254_RS03320	COG3629	intracellular signal transduction
CU254_RS03320	COG3903	Transcriptional regulator
CU254_RS03330	COG1388	LysM domain
CU254_RS03330	COG3103	Sh3 type 3 domain protein
CU254_RS03330	COG0791	NLP P60 protein
CU254_RS03365	COG0483	inositol monophosphate 1-phosphatase activity
CU254_RS03370	COG0745	RESPONSE REGULATOR receiver
CU254_RS03375	COG2205	protein histidine kinase activity
CU254_RS03420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CU254_RS03425	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS03455	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CU254_RS03480	COG1316	TRANSCRIPTIONal
CU254_RS03485	COG1316	TRANSCRIPTIONal
CU254_RS03570	COG1725	Transcriptional regulator
CU254_RS03585	COG0778	Nitroreductase
CU254_RS03585	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CU254_RS03590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CU254_RS03600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CU254_RS03635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_RS03655	COG1611	Belongs to the LOG family
CU254_RS03670	COG0463	Glycosyl transferase, family 2
CU254_RS03680	COG0842	Transport permease protein
CU254_RS03680	COG1131	(ABC) transporter
CU254_RS03680	COG1716	ATPase activity
CU254_RS03685	COG4988	ABC transporter
CU254_RS03690	COG1294	oxidase, subunit
CU254_RS03695	COG1271	oxidase subunit
CU254_RS03720	COG2818	Glycosylase
CU254_RS03725	COG1024	Enoyl-CoA hydratase
CU254_RS03735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CU254_RS03745	COG0583	DNA-binding transcription factor activity
CU254_RS03750	COG2814	Major facilitator Superfamily
CU254_RS03755	COG4122	O-methyltransferase activity
CU254_RS03775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU254_RS03780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU254_RS03800	COG2239	Acts as a magnesium transporter
CU254_RS03805	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
CU254_RS03810	COG0330	HflC and HflK could
CU254_RS03825	COG1960	acyl-CoA dehydrogenase activity
CU254_RS03870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CU254_RS03885	COG0598	Magnesium transport protein CorA
CU254_RS03915	COG0613	PHP domain protein
CU254_RS03920	COG2095	MarC family integral membrane protein
CU254_RS03940	COG0513	Belongs to the DEAD box helicase family
CU254_RS03970	COG2267	carboxylic ester hydrolase activity
CU254_RS04015	COG0243	molybdopterin cofactor binding
CU254_RS04020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU254_RS04025	COG2223	nitrite transmembrane transporter activity
CU254_RS04030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU254_RS04030	COG2146	nitrite reductase [NAD(P)H] activity
CU254_RS04035	COG2146	nitrite reductase [NAD(P)H] activity
CU254_RS04035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU254_RS04065	COG2378	regulation of single-species biofilm formation
CU254_RS04080	COG2801	Transposase and inactivated derivatives
CU254_RS04135	COG0714	Associated with various cellular activities
CU254_RS04140	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CU254_RS04170	COG0612	Peptidase, M16
CU254_RS04190	COG1175	transmembrane transport
CU254_RS04195	COG0395	ABC-type sugar transport system, permease component
CU254_RS04200	COG1486	melibiose metabolic process
CU254_RS04215	COG0640	Transcriptional regulator
CU254_RS04225	COG3265	gluconokinase activity
CU254_RS04255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CU254_RS04275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU254_RS04340	COG0557	exoribonuclease II activity
CU254_RS04345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU254_RS04350	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS04375	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS04380	COG3842	ATPase activity
CU254_RS04385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CU254_RS04390	COG1176	ABC-type spermidine putrescine transport system, permease component I
CU254_RS04395	COG1177	transmembrane transport
CU254_RS04400	COG0596	Alpha beta hydrolase
CU254_RS04410	COG1968	undecaprenyl-diphosphatase activity
CU254_RS04420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CU254_RS04435	COG2318	DinB family
CU254_RS04445	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CU254_RS04445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU254_RS04450	COG0653	protein targeting
CU254_RS04470	COG0174	glutamine synthetase
CU254_RS04475	COG0154	amidase activity
CU254_RS04495	COG1522	sequence-specific DNA binding
CU254_RS04505	COG0505	Belongs to the CarA family
CU254_RS04515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CU254_RS04530	COG2080	2 iron, 2 sulfur cluster binding
CU254_RS04535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CU254_RS04540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU254_RS04590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CU254_RS04650	COG0300	oxidoreductase activity
CU254_RS04690	COG1396	sequence-specific DNA binding
CU254_RS04695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_RS04700	COG1309	transcriptional regulator
CU254_RS04710	COG3012	SEC-C Motif Domain Protein
CU254_RS04720	COG0640	Transcriptional regulator
CU254_RS04725	COG0798	PFAM Bile acid sodium symporter
CU254_RS04730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CU254_RS04735	COG0174	glutamine synthetase
CU254_RS04810	COG3480	Lon protease (S16) C-terminal proteolytic domain
CU254_RS04820	COG1615	UPF0182 protein
CU254_RS04840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CU254_RS04845	COG2884	Cell division ATP-binding protein ftsE
CU254_RS04850	COG2177	Part of the ABC transporter FtsEX involved in
CU254_RS04855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CU254_RS04875	COG2197	response regulator
CU254_RS04880	COG4585	Histidine kinase
CU254_RS04900	COG2226	methyltransferase
CU254_RS04920	COG2986	histidine ammonia-lyase
CU254_RS04925	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CU254_RS04935	COG0402	S-adenosylhomocysteine deaminase activity
CU254_RS04940	COG1228	amidohydrolase
CU254_RS04970	COG4585	Histidine kinase
CU254_RS04975	COG2197	response regulator
CU254_RS04995	COG1131	(ABC) transporter
CU254_RS05000	COG1643	Atp-dependent helicase
CU254_RS05005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_RS05025	COG0791	NLP P60 protein
CU254_RS05025	COG3883	PFAM NLP P60 protein
CU254_RS05040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU254_RS05040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU254_RS05045	COG0187	DNA topoisomerase II activity
CU254_RS05085	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_RS05090	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_RS05095	COG1129	ABC transporter
CU254_RS05100	COG1879	ABC-type sugar transport system periplasmic component
CU254_RS05105	COG1609	Transcriptional regulator
CU254_RS05120	COG5640	endopeptidase activity
CU254_RS05140	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS05180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CU254_RS05195	COG3250	beta-galactosidase activity
CU254_RS05200	COG0395	ABC-type sugar transport system, permease component
CU254_RS05205	COG1175	transmembrane transport
CU254_RS05215	COG1609	Transcriptional regulator
CU254_RS05245	COG3706	GGDEF domain
CU254_RS05265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CU254_RS05280	COG2814	Major facilitator Superfamily
CU254_RS05300	COG3467	pyridoxamine 5'-phosphate
CU254_RS05305	COG2353	YceI-like domain
CU254_RS05315	COG0435	Glutathione S-transferase
CU254_RS05320	COG0596	Alpha beta hydrolase
CU254_RS05355	COG1247	-acetyltransferase
CU254_RS05360	COG1396	sequence-specific DNA binding
CU254_RS05380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU254_RS05390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU254_RS05425	COG4585	Histidine kinase
CU254_RS05430	COG2197	response regulator
CU254_RS05470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CU254_RS05485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU254_RS05490	COG4585	Histidine kinase
CU254_RS05575	COG0740	serine-type endopeptidase activity
CU254_RS05580	COG0740	serine-type endopeptidase activity
CU254_RS05585	COG1396	sequence-specific DNA binding
CU254_RS05595	COG0076	glutamate decarboxylase activity
CU254_RS05600	COG2814	Major facilitator Superfamily
CU254_RS05605	COG0656	L-ascorbic acid biosynthetic process
CU254_RS05665	COG2746	aminoglycoside 3-N-acetyltransferase activity
CU254_RS05675	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CU254_RS05680	COG1846	Transcriptional regulator
CU254_RS05710	COG0745	RESPONSE REGULATOR receiver
CU254_RS05715	COG2205	protein histidine kinase activity
CU254_RS05720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU254_RS05725	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CU254_RS05730	COG1181	Belongs to the D-alanine--D-alanine ligase family
CU254_RS05750	COG3903	Transcriptional regulator
CU254_RS05750	COG3629	intracellular signal transduction
CU254_RS05760	COG2197	response regulator
CU254_RS05765	COG4585	Histidine kinase
CU254_RS05795	COG0702	epimerase
CU254_RS05820	COG2124	cytochrome p450
CU254_RS05840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CU254_RS05855	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS05870	COG0604	alcohol dehydrogenase
CU254_RS05870	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS05870	COG3321	synthase
CU254_RS05875	COG2986	histidine ammonia-lyase
CU254_RS05885	COG0028	Belongs to the TPP enzyme family
CU254_RS05885	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CU254_RS05960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CU254_RS05965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU254_RS06000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_RS06005	COG0765	amino acid transport
CU254_RS06010	COG1126	abc transporter atp-binding protein
CU254_RS06025	COG1131	(ABC) transporter
CU254_RS06030	COG0842	Transport permease protein
CU254_RS06060	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS06095	COG1879	ABC-type sugar transport system periplasmic component
CU254_RS06110	COG3903	Transcriptional regulator
CU254_RS06110	COG3629	intracellular signal transduction
CU254_RS06120	COG2211	Major facilitator Superfamily
CU254_RS06130	COG4221	oxidoreductase activity
CU254_RS06135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CU254_RS06150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU254_RS06160	COG1278	Cold shock
CU254_RS06165	COG0513	Belongs to the DEAD box helicase family
CU254_RS06185	COG2183	response to ionizing radiation
CU254_RS06195	COG2072	flavoprotein involved in K transport
CU254_RS06215	COG2814	Major facilitator Superfamily
CU254_RS06230	COG0477	Major facilitator Superfamily
CU254_RS06245	COG4977	sequence-specific DNA binding
CU254_RS06260	COG1309	transcriptional regulator
CU254_RS06275	COG2030	dehydratase
CU254_RS06275	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS06280	COG3396	Phenylacetate-CoA oxygenase
CU254_RS06285	COG3460	Phenylacetate-CoA oxygenase
CU254_RS06290	COG3396	Phenylacetate-CoA oxygenase
CU254_RS06295	COG2151	metal-sulfur cluster biosynthetic enzyme
CU254_RS06300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU254_RS06315	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CU254_RS06345	COG0346	lactoylglutathione lyase activity
CU254_RS06350	COG0183	Belongs to the thiolase family
CU254_RS06375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_RS06380	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CU254_RS06385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_RS06395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_RS06405	COG3279	Response regulator of the LytR AlgR family
CU254_RS06410	COG3275	phosphorelay sensor kinase activity
CU254_RS06415	COG1879	ABC-type sugar transport system periplasmic component
CU254_RS06420	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_RS06435	COG1609	Transcriptional regulator
CU254_RS06440	COG3537	Alpha-1,2-mannosidase
CU254_RS06445	COG3537	Alpha-1,2-mannosidase
CU254_RS06455	COG1846	Transcriptional regulator
CU254_RS06480	COG0058	SHG alpha-glucan phosphorylase activity
CU254_RS06500	COG1119	ATPase activity
CU254_RS06505	COG1024	Enoyl-CoA hydratase
CU254_RS06510	COG2226	methyltransferase
CU254_RS06525	COG3979	chitinase
CU254_RS06530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CU254_RS06545	COG3634	alkyl hydroperoxide reductase activity
CU254_RS06565	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS06580	COG1309	transcriptional regulator
CU254_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS06620	COG3883	PFAM NLP P60 protein
CU254_RS06620	COG0791	NLP P60 protein
CU254_RS06630	COG0110	maltose O-acetyltransferase activity
CU254_RS06655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CU254_RS06660	COG2076	Multidrug Resistance protein
CU254_RS06670	COG0596	Alpha beta hydrolase
CU254_RS06690	COG0386	Belongs to the glutathione peroxidase family
CU254_RS06700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU254_RS06710	COG1307	EDD domain protein, DegV family
CU254_RS06720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CU254_RS06750	COG0482	sulfurtransferase activity
CU254_RS06765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS06785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CU254_RS06805	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CU254_RS06810	COG0154	amidase activity
CU254_RS06815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CU254_RS06840	COG0129	dihydroxy-acid dehydratase activity
CU254_RS06855	COG0440	acetolactate synthase activity
CU254_RS06860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CU254_RS06925	COG1404	Belongs to the peptidase S8 family
CU254_RS06930	COG0473	3-isopropylmalate dehydrogenase activity
CU254_RS06935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_RS06940	COG1120	ATPase activity
CU254_RS06950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU254_RS06955	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU254_RS07000	COG4176	ABC-type proline glycine betaine transport system permease component
CU254_RS07005	COG4175	Glycine betaine
CU254_RS07005	COG3448	diguanylate cyclase activity
CU254_RS07020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CU254_RS07025	COG0066	3-isopropylmalate dehydratase activity
CU254_RS07030	COG0776	regulation of translation
CU254_RS07045	COG1920	GTP binding
CU254_RS07055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CU254_RS07065	COG0252	asparaginase activity
CU254_RS07080	COG0745	RESPONSE REGULATOR receiver
CU254_RS07085	COG2205	protein histidine kinase activity
CU254_RS07095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS07110	COG0477	Major facilitator Superfamily
CU254_RS07135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CU254_RS07140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CU254_RS07150	COG2801	Transposase and inactivated derivatives
CU254_RS07155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CU254_RS07160	COG1461	Dihydroxyacetone kinase
CU254_RS07195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CU254_RS07255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CU254_RS07280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU254_RS07295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS07300	COG3973	AAA domain
CU254_RS07305	COG0742	ribosomal rna small subunit methyltransferase
CU254_RS07310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CU254_RS07335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CU254_RS07340	COG0571	ribonuclease III activity
CU254_RS07345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CU254_RS07370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CU254_RS07375	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS07385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CU254_RS07385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CU254_RS07390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CU254_RS07395	COG0509	glycine decarboxylation via glycine cleavage system
CU254_RS07400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CU254_RS07405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CU254_RS07410	COG1760	l-serine dehydratase
CU254_RS07420	COG2186	Transcriptional regulator
CU254_RS07425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_RS07430	COG1120	ATPase activity
CU254_RS07435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS07440	COG4221	oxidoreductase activity
CU254_RS07450	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU254_RS07455	COG2814	Major facilitator Superfamily
CU254_RS07460	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU254_RS07465	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_RS07480	COG1129	ABC transporter
CU254_RS07495	COG2186	Transcriptional regulator
CU254_RS07530	COG1929	Belongs to the glycerate kinase type-1 family
CU254_RS07540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CU254_RS07545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CU254_RS07555	COG3485	protocatechuate 3,4-dioxygenase
CU254_RS07560	COG3485	protocatechuate 3,4-dioxygenase
CU254_RS07565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU254_RS07570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_RS07575	COG1414	Transcriptional regulator
CU254_RS07580	COG0746	molybdenum cofactor guanylyltransferase activity
CU254_RS07620	COG3706	GGDEF domain
CU254_RS07655	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_RS07665	COG1082	Xylose isomerase domain protein TIM barrel
CU254_RS07670	COG1609	Transcriptional regulator
CU254_RS07675	COG0673	inositol 2-dehydrogenase activity
CU254_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS07695	COG0367	asparagine synthase
CU254_RS07705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CU254_RS07710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CU254_RS07715	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CU254_RS07735	COG1254	Belongs to the acylphosphatase family
CU254_RS07755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_RS07760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CU254_RS07775	COG1414	Transcriptional regulator
CU254_RS07780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CU254_RS07795	COG0326	Molecular chaperone. Has ATPase activity
CU254_RS07815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU254_RS07820	COG1309	transcriptional regulator
CU254_RS07825	COG2233	PERMEase
CU254_RS07850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU254_RS07855	COG4266	Belongs to the allantoicase family
CU254_RS07880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_RS07890	COG1832	CoA-binding protein
CU254_RS07895	COG2873	o-acetylhomoserine
CU254_RS07920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CU254_RS07940	COG1132	(ABC) transporter
CU254_RS07965	COG0228	four-way junction DNA binding
CU254_RS07975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CU254_RS07985	COG0336	Belongs to the RNA methyltransferase TrmD family
CU254_RS07990	COG0335	large ribosomal subunit rRNA binding
CU254_RS07995	COG0681	Belongs to the peptidase S26 family
CU254_RS08000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CU254_RS08010	COG0792	nuclease activity
CU254_RS08035	COG1191	sigma factor activity
CU254_RS08045	COG0052	Belongs to the universal ribosomal protein uS2 family
CU254_RS08050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CU254_RS08055	COG0528	UMP kinase activity
CU254_RS08060	COG0233	cytoplasmic translational termination
CU254_RS08075	COG2226	methyltransferase
CU254_RS08080	COG1695	Transcriptional regulator
CU254_RS08090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CU254_RS08095	COG2197	response regulator
CU254_RS08120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CU254_RS08130	COG2070	2-Nitropropane dioxygenase
CU254_RS08150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CU254_RS08195	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CU254_RS08225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_RS08235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CU254_RS08255	COG1846	Transcriptional regulator
CU254_RS08265	COG0277	FAD linked oxidase domain protein
CU254_RS08270	COG2814	Major facilitator Superfamily
CU254_RS08280	COG0477	Major facilitator Superfamily
CU254_RS08285	COG0431	NADPH-dependent FMN reductase
CU254_RS08295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CU254_RS08305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CU254_RS08315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CU254_RS08365	COG3345	alpha-galactosidase
CU254_RS08370	COG0456	acetyltransferase
CU254_RS08370	COG0454	-acetyltransferase
CU254_RS08380	COG2186	Transcriptional regulator
CU254_RS08385	COG2807	transmembrane transport
CU254_RS08420	COG0513	Belongs to the DEAD box helicase family
CU254_RS08430	COG0667	Aldo Keto reductase
CU254_RS08440	COG3022	response to hydroperoxide
CU254_RS08455	COG0442	prolyl-tRNA aminoacylation
CU254_RS08465	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CU254_RS08480	COG2197	response regulator
CU254_RS08500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU254_RS08510	COG0346	lactoylglutathione lyase activity
CU254_RS08560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU254_RS08575	COG4152	abc transporter atp-binding protein
CU254_RS08580	COG1668	transmembrane transport
CU254_RS08590	COG3201	nicotinamide mononucleotide transporter
CU254_RS08605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CU254_RS08625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU254_RS08635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CU254_RS08650	COG1113	amino acid transport
CU254_RS08660	COG0587	DNA-directed DNA polymerase activity
CU254_RS08665	COG0477	Major facilitator Superfamily
CU254_RS08695	COG1376	ErfK ybiS ycfS ynhG family protein
CU254_RS08700	COG4667	esterase of the alpha-beta hydrolase superfamily
CU254_RS08705	COG0586	Pfam SNARE associated Golgi protein
CU254_RS08710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CU254_RS08735	COG0321	lipoyl(octanoyl) transferase activity
CU254_RS08745	COG1090	epimerase
CU254_RS08760	COG2826	transposase and inactivated derivatives, IS30 family
CU254_RS08765	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU254_RS08770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU254_RS08810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU254_RS08820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CU254_RS08825	COG0667	Aldo Keto reductase
CU254_RS08845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_RS08855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CU254_RS08875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CU254_RS08890	COG1845	cytochrome c oxidase, subunit III
CU254_RS08895	COG2010	Cytochrome c
CU254_RS08905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CU254_RS08945	COG0438	transferase activity, transferring glycosyl groups
CU254_RS08960	COG2124	cytochrome p450
CU254_RS08965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU254_RS08970	COG0659	secondary active sulfate transmembrane transporter activity
CU254_RS08975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CU254_RS08985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CU254_RS08995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CU254_RS09000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CU254_RS09010	COG1404	Belongs to the peptidase S8 family
CU254_RS09080	COG1674	ftsk spoiiie
CU254_RS09105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CU254_RS09120	COG0477	Major facilitator Superfamily
CU254_RS09125	COG4977	sequence-specific DNA binding
CU254_RS09155	COG2197	response regulator
CU254_RS09160	COG2197	response regulator
CU254_RS09170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CU254_RS09175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU254_RS09180	COG0131	Imidazoleglycerol-phosphate dehydratase
CU254_RS09190	COG1234	tRNA 3'-trailer cleavage
CU254_RS09200	COG2409	Drug exporters of the RND superfamily
CU254_RS09205	COG1309	transcriptional regulator
CU254_RS09210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU254_RS09220	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CU254_RS09230	COG3959	Transketolase, thiamine diphosphate binding domain
CU254_RS09235	COG3958	Transketolase
CU254_RS09245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CU254_RS09250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CU254_RS09295	COG0107	imidazoleglycerol-phosphate synthase activity
CU254_RS09315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CU254_RS09325	COG0134	indole-3-glycerol-phosphate synthase activity
CU254_RS09330	COG0133	tryptophan synthase activity
CU254_RS09335	COG0159	tryptophan synthase activity
CU254_RS09365	COG1473	amidohydrolase
CU254_RS09370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CU254_RS09390	COG0070	glutamate synthase
CU254_RS09390	COG0067	glutamate synthase
CU254_RS09390	COG0069	glutamate synthase activity
CU254_RS09405	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CU254_RS09420	COG2268	Band 7 protein
CU254_RS09430	COG2815	serine threonine protein kinase
CU254_RS09430	COG0515	serine threonine protein kinase
CU254_RS09460	COG0142	geranyltranstransferase activity
CU254_RS09525	COG0242	peptide deformylase activity
CU254_RS09530	COG1201	RNA secondary structure unwinding
CU254_RS09540	COG0443	Heat shock 70 kDa protein
CU254_RS09550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CU254_RS09555	COG2137	regulation of response to DNA damage stimulus
CU254_RS09560	COG0800	Aldolase
CU254_RS09585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CU254_RS09660	COG0765	amino acid transport
CU254_RS09665	COG0765	amino acid transport
CU254_RS09670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_RS09675	COG1126	abc transporter atp-binding protein
CU254_RS09685	COG0642	Histidine kinase
CU254_RS09700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU254_RS09710	COG1196	nuclear chromosome segregation
CU254_RS09715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CU254_RS09725	COG0525	valine-tRNA ligase activity
CU254_RS09740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CU254_RS09750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CU254_RS09760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CU254_RS09765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU254_RS09770	COG1309	transcriptional regulator
CU254_RS09810	COG1505	serine-type exopeptidase activity
CU254_RS09840	COG2936	dipeptidyl-peptidase activity
CU254_RS09845	COG2197	response regulator
CU254_RS09850	COG4585	Histidine kinase
CU254_RS09865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU254_RS09870	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CU254_RS09890	COG0123	including yeast histone deacetylase and acetoin utilization protein
CU254_RS09900	COG1960	acyl-CoA dehydrogenase activity
CU254_RS09905	COG1960	acyl-CoA dehydrogenase activity
CU254_RS09925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU254_RS09930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CU254_RS10000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS10035	COG0003	Pfam Anion-transporting ATPase
CU254_RS10045	COG1940	carbohydrate kinase activity
CU254_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS10060	COG1309	transcriptional regulator
CU254_RS10070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CU254_RS10100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CU254_RS10140	COG0640	Transcriptional regulator
CU254_RS10160	COG1946	Acyl-CoA thioesterase
CU254_RS10180	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CU254_RS10180	COG1672	PFAM Archaeal ATPase
CU254_RS10190	COG3226	Transcriptional regulator
CU254_RS10195	COG1960	acyl-CoA dehydrogenase activity
CU254_RS10200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_RS10220	COG1566	PFAM secretion protein HlyD family protein
CU254_RS10230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_RS10245	COG2018	Roadblock/LC7 domain
CU254_RS10280	COG1703	isobutyryl-CoA mutase activity
CU254_RS10280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CU254_RS10280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CU254_RS10290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS10295	COG1960	acyl-CoA dehydrogenase activity
CU254_RS10300	COG1309	transcriptional regulator
CU254_RS10345	COG0302	gtp cyclohydrolase
CU254_RS10350	COG0657	acetylesterase activity
CU254_RS10355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_RS10380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU254_RS10385	COG1960	acyl-CoA dehydrogenase activity
CU254_RS10390	COG1960	acyl-CoA dehydrogenase activity
CU254_RS10395	COG2030	dehydratase
CU254_RS10420	COG0196	riboflavin kinase activity
CU254_RS10425	COG2030	dehydratase
CU254_RS10445	COG1053	succinate dehydrogenase
CU254_RS10455	COG1960	acyl-CoA dehydrogenase activity
CU254_RS10460	COG2267	carboxylic ester hydrolase activity
CU254_RS10465	COG0346	lactoylglutathione lyase activity
CU254_RS10470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_RS10485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS10505	COG2084	Dehydrogenase
CU254_RS10515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_RS10530	COG0596	Alpha beta hydrolase
CU254_RS10545	COG0183	Belongs to the thiolase family
CU254_RS10550	COG2124	cytochrome p450
CU254_RS10560	COG1295	ribonuclease BN
CU254_RS10570	COG0183	Belongs to the thiolase family
CU254_RS10585	COG1024	Enoyl-CoA hydratase
CU254_RS10595	COG2070	2-Nitropropane dioxygenase
CU254_RS10620	COG2188	Transcriptional regulator
CU254_RS10630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_RS10635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_RS10675	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CU254_RS10675	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CU254_RS10685	COG1490	D-aminoacyl-tRNA deacylase activity
CU254_RS10690	COG2890	protein-(glutamine-N5) methyltransferase activity
CU254_RS10710	COG2313	pseudouridylate synthase activity
CU254_RS10740	COG4213	ABC transporter substrate-binding protein
CU254_RS10750	COG4214	carbohydrate transport
CU254_RS10770	COG0174	glutamine synthetase
CU254_RS10780	COG1733	regulation of RNA biosynthetic process
CU254_RS10785	COG2910	NAD(P)H-binding
CU254_RS10790	COG0531	amino acid
CU254_RS10800	COG4585	Histidine kinase
CU254_RS10855	COG1940	carbohydrate kinase activity
CU254_RS10860	COG0483	inositol monophosphate 1-phosphatase activity
CU254_RS10880	COG0756	dUTP diphosphatase activity
CU254_RS10910	COG0569	domain protein
CU254_RS10915	COG0531	amino acid
CU254_RS10920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CU254_RS10940	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS10945	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CU254_RS10970	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS11000	COG0745	RESPONSE REGULATOR receiver
CU254_RS11005	COG2205	protein histidine kinase activity
CU254_RS11025	COG1024	Enoyl-CoA hydratase
CU254_RS11025	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS11030	COG0183	Belongs to the thiolase family
CU254_RS11040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS11040	COG1024	Enoyl-CoA hydratase
CU254_RS11050	COG1414	Transcriptional regulator
CU254_RS11060	COG2197	response regulator
CU254_RS11070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CU254_RS11080	COG3253	May function as heme-dependent peroxidase
CU254_RS11085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_RS11100	COG3220	belongs to the UPF0276 family
CU254_RS11120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU254_RS11130	COG2815	serine threonine protein kinase
CU254_RS11130	COG0515	serine threonine protein kinase
CU254_RS11150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS11160	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CU254_RS11160	COG2508	Transcriptional regulator
CU254_RS11165	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS11170	COG0506	proline dehydrogenase activity
CU254_RS11175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU254_RS11195	COG1793	dna ligase
CU254_RS11245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU254_RS11250	COG2326	polyphosphate kinase activity
CU254_RS11270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CU254_RS11325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CU254_RS11340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CU254_RS11345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU254_RS11365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU254_RS11370	COG1263	PTS System
CU254_RS11375	COG2188	Transcriptional regulator
CU254_RS11380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU254_RS11415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CU254_RS11420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CU254_RS11425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CU254_RS11430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CU254_RS11450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CU254_RS11455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CU254_RS11465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CU254_RS11470	COG0540	Belongs to the ATCase OTCase family
CU254_RS11485	COG0505	Belongs to the CarA family
CU254_RS11495	COG0284	orotidine-5'-phosphate decarboxylase activity
CU254_RS11505	COG0194	GDP metabolic process
CU254_RS11510	COG1758	RNA polymerase activity
CU254_RS11520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CU254_RS11550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU254_RS11565	COG1610	YqeY-like protein
CU254_RS11570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CU254_RS11600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU254_RS11600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU254_RS11605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CU254_RS11620	COG0322	excinuclease ABC activity
CU254_RS11625	COG1660	Displays ATPase and GTPase activities
CU254_RS11630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CU254_RS11635	COG1481	regulation of sporulation
CU254_RS11640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS11645	COG2133	pyrroloquinoline quinone binding
CU254_RS11675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CU254_RS11680	COG0126	phosphoglycerate kinase activity
CU254_RS11685	COG0149	triose-phosphate isomerase activity
CU254_RS11700	COG4585	Histidine kinase
CU254_RS11710	COG0363	glucosamine-6-phosphate deaminase activity
CU254_RS11725	COG0166	Belongs to the GPI family
CU254_RS11730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CU254_RS11740	COG0109	protoheme IX farnesyltransferase activity
CU254_RS11780	COG1612	heme a metabolic process
CU254_RS11790	COG1131	(ABC) transporter
CU254_RS11830	COG2151	metal-sulfur cluster biosynthetic enzyme
CU254_RS11845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CU254_RS11850	COG5640	endopeptidase activity
CU254_RS11855	COG2226	methyltransferase
CU254_RS11860	COG4585	Histidine kinase
CU254_RS11865	COG2197	response regulator
CU254_RS11870	COG2200	EAL domain
CU254_RS11870	COG2199	diguanylate cyclase activity
CU254_RS11875	COG0644	oxidoreductase
CU254_RS11900	COG0488	(ABC) transporter
CU254_RS11915	COG1132	(ABC) transporter
CU254_RS11930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU254_RS11935	COG1316	TRANSCRIPTIONal
CU254_RS11975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CU254_RS11980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CU254_RS11990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU254_RS11995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CU254_RS11995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU254_RS12020	COG1960	acyl-CoA dehydrogenase activity
CU254_RS12025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU254_RS12050	COG3469	chitinase activity
CU254_RS12075	COG1309	transcriptional regulator
CU254_RS12085	COG1132	(ABC) transporter
CU254_RS12090	COG1132	(ABC) transporter
CU254_RS12095	COG1505	serine-type exopeptidase activity
CU254_RS12105	COG0515	serine threonine protein kinase
CU254_RS12125	COG0546	phosphoglycolate phosphatase activity
CU254_RS12175	COG1846	Transcriptional regulator
CU254_RS12180	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS12215	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CU254_RS12230	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS12245	COG0477	Major facilitator Superfamily
CU254_RS12305	COG0402	S-adenosylhomocysteine deaminase activity
CU254_RS12325	COG2368	4-hydroxyphenylacetate
CU254_RS12350	COG1984	allophanate hydrolase subunit 2
CU254_RS12380	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CU254_RS12400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CU254_RS12420	COG1984	allophanate hydrolase subunit 2
CU254_RS12455	COG4552	Acetyltransferase involved in intracellular survival and related
CU254_RS12465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU254_RS12495	COG0577	efflux transmembrane transporter activity
CU254_RS12500	COG4585	Histidine kinase
CU254_RS12505	COG2197	response regulator
CU254_RS12560	COG1063	alcohol dehydrogenase
CU254_RS12570	COG0154	amidase activity
CU254_RS12575	COG2223	nitrite transmembrane transporter activity
CU254_RS12580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS12645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CU254_RS12740	COG3033	Beta-eliminating lyase
CU254_RS12760	COG2186	Transcriptional regulator
CU254_RS12765	COG0346	lactoylglutathione lyase activity
CU254_RS12790	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS12795	COG2186	Transcriptional regulator
CU254_RS12805	COG0747	negative chemotaxis
CU254_RS12815	COG0444	Belongs to the ABC transporter superfamily
CU254_RS12835	COG0028	Belongs to the TPP enzyme family
CU254_RS12850	COG0022	dehydrogenase e1 component
CU254_RS12855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU254_RS12860	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CU254_RS12900	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CU254_RS12910	COG0596	Alpha beta hydrolase
CU254_RS12940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CU254_RS12950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_RS12980	COG1021	2,3-dihydroxybenzoate-AMP ligase
CU254_RS12985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_RS12990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_RS12995	COG1169	isochorismate synthase
CU254_RS13000	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CU254_RS13005	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS13015	COG0477	Major facilitator Superfamily
CU254_RS13020	COG3469	chitinase activity
CU254_RS13025	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU254_RS13025	COG0456	acetyltransferase
CU254_RS13030	COG1960	acyl-CoA dehydrogenase activity
CU254_RS13035	COG1960	acyl-CoA dehydrogenase activity
CU254_RS13040	COG1960	acyl-CoA dehydrogenase activity
CU254_RS13065	COG0484	heat shock protein binding
CU254_RS13075	COG0531	amino acid
CU254_RS13080	COG3250	beta-galactosidase activity
CU254_RS13100	COG2124	cytochrome p450
CU254_RS13135	COG1846	Transcriptional regulator
CU254_RS13145	COG0477	Major facilitator Superfamily
CU254_RS13155	COG1793	dna ligase
CU254_RS13225	COG2807	transmembrane transport
CU254_RS13235	COG1309	transcriptional regulator
CU254_RS13245	COG2814	Major facilitator Superfamily
CU254_RS13260	COG0587	DNA-directed DNA polymerase activity
CU254_RS13270	COG0439	Biotin carboxylase
CU254_RS13275	COG1129	ABC transporter
CU254_RS13280	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU254_RS13310	COG0656	L-ascorbic acid biosynthetic process
CU254_RS13315	COG0297	glycogen (starch) synthase activity
CU254_RS13340	COG0069	glutamate synthase activity
CU254_RS13365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_RS13375	COG1131	(ABC) transporter
CU254_RS13395	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS13405	COG2890	protein-(glutamine-N5) methyltransferase activity
CU254_RS13410	COG0297	glycogen (starch) synthase activity
CU254_RS13415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU254_RS13430	COG2188	Transcriptional regulator
CU254_RS13450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_RS13455	COG4608	Belongs to the ABC transporter superfamily
CU254_RS13460	COG0444	Belongs to the ABC transporter superfamily
CU254_RS13470	COG0747	negative chemotaxis
CU254_RS13475	COG2186	Transcriptional regulator
CU254_RS13490	COG0673	inositol 2-dehydrogenase activity
CU254_RS13510	COG2205	protein histidine kinase activity
CU254_RS13515	COG0745	RESPONSE REGULATOR receiver
CU254_RS13525	COG4941	Belongs to the sigma-70 factor family
CU254_RS13530	COG3795	YCII-related domain
CU254_RS13575	COG1309	transcriptional regulator
CU254_RS13630	COG1960	acyl-CoA dehydrogenase activity
CU254_RS13660	COG2124	cytochrome p450
CU254_RS13665	COG1309	transcriptional regulator
CU254_RS13670	COG2801	Transposase and inactivated derivatives
CU254_RS13690	COG2423	ornithine cyclodeaminase activity
CU254_RS13695	COG4106	trans-aconitate 2-methyltransferase activity
CU254_RS13705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_RS13720	COG0148	phosphopyruvate hydratase activity
CU254_RS13735	COG4991	sh3 domain protein
CU254_RS13740	COG0702	epimerase
CU254_RS13750	COG4941	Belongs to the sigma-70 factor family
CU254_RS13770	COG2188	Transcriptional regulator
CU254_RS13790	COG0488	(ABC) transporter
CU254_RS13835	COG5006	permease, DMT superfamily
CU254_RS13885	COG0583	DNA-binding transcription factor activity
CU254_RS13890	COG2814	Major facilitator Superfamily
CU254_RS13895	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS13915	COG1657	PFAM Prenyltransferase squalene oxidase
CU254_RS13925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CU254_RS13935	COG1562	ergosterol biosynthetic process
CU254_RS13945	COG0300	oxidoreductase activity
CU254_RS13955	COG0697	spore germination
CU254_RS13970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU254_RS13975	COG0583	DNA-binding transcription factor activity
CU254_RS13985	COG1119	ATPase activity
CU254_RS14015	COG1120	ATPase activity
CU254_RS14035	COG1126	abc transporter atp-binding protein
CU254_RS14045	COG0277	FAD linked oxidase domain protein
CU254_RS14050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CU254_RS14080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS14095	COG1609	Transcriptional regulator
CU254_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS14145	COG3537	Alpha-1,2-mannosidase
CU254_RS14150	COG2814	Major facilitator Superfamily
CU254_RS14155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CU254_RS14225	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CU254_RS14260	COG3629	intracellular signal transduction
CU254_RS14260	COG3903	Transcriptional regulator
CU254_RS14275	COG2814	Major facilitator Superfamily
CU254_RS14280	COG0387	Pfam Sodium calcium exchanger
CU254_RS14300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU254_RS14320	COG2378	regulation of single-species biofilm formation
CU254_RS14330	COG2267	carboxylic ester hydrolase activity
CU254_RS14360	COG0535	radical SAM domain protein
CU254_RS14425	COG1169	isochorismate synthase
CU254_RS14435	COG2197	response regulator
CU254_RS14440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU254_RS14475	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS14480	COG1024	Enoyl-CoA hydratase
CU254_RS14490	COG1024	Enoyl-CoA hydratase
CU254_RS14495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU254_RS14505	COG2271	Major facilitator Superfamily
CU254_RS14515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_RS14535	COG0477	Major facilitator Superfamily
CU254_RS14550	COG0438	transferase activity, transferring glycosyl groups
CU254_RS14560	COG0477	Major facilitator Superfamily
CU254_RS14565	COG3962	Belongs to the TPP enzyme family
CU254_RS14570	COG3718	enzyme involved in inositol metabolism
CU254_RS14585	COG2188	Transcriptional regulator
CU254_RS14595	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CU254_RS14605	COG0247	lactate metabolic process
CU254_RS14605	COG0277	FAD linked oxidase domain protein
CU254_RS14610	COG2186	Transcriptional regulator
CU254_RS14625	COG4447	cellulose binding
CU254_RS14745	COG0438	transferase activity, transferring glycosyl groups
CU254_RS14880	COG3447	MASE1 domain protein
CU254_RS14880	COG5002	protein histidine kinase activity
CU254_RS14880	COG5001	Diguanylate cyclase
CU254_RS14900	COG0596	Alpha beta hydrolase
CU254_RS14915	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CU254_RS14935	COG2197	response regulator
CU254_RS14955	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS14970	COG1176	ABC-type spermidine putrescine transport system, permease component I
CU254_RS14975	COG1177	transmembrane transport
CU254_RS14980	COG3842	ATPase activity
CU254_RS14990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_RS15050	COG2261	transglycosylase associated protein
CU254_RS15055	COG1595	DNA-templated transcription, initiation
CU254_RS15060	COG2226	methyltransferase
CU254_RS15075	COG3511	phospholipase C
CU254_RS15085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS15100	COG0640	Transcriptional regulator
CU254_RS15125	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS15135	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS15140	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CU254_RS15170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU254_RS15180	COG0596	Alpha beta hydrolase
CU254_RS15200	COG0477	Major facilitator Superfamily
CU254_RS15245	COG1136	(ABC) transporter
CU254_RS15265	COG2072	flavoprotein involved in K transport
CU254_RS15275	COG2186	Transcriptional regulator
CU254_RS15290	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS15295	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS15300	COG0154	amidase activity
CU254_RS15310	COG1960	acyl-CoA dehydrogenase activity
CU254_RS15315	COG1960	acyl-CoA dehydrogenase activity
CU254_RS15320	COG1960	acyl-CoA dehydrogenase activity
CU254_RS15325	COG1024	Enoyl-CoA hydratase
CU254_RS15330	COG1960	acyl-CoA dehydrogenase activity
CU254_RS15345	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_RS15350	COG1454	alcohol dehydrogenase
CU254_RS15355	COG0531	amino acid
CU254_RS15400	COG0531	amino acid
CU254_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS15435	COG0277	FAD linked oxidase domain protein
CU254_RS15435	COG0247	lactate metabolic process
CU254_RS15440	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_RS15445	COG0028	Belongs to the TPP enzyme family
CU254_RS15450	COG3387	PFAM Glycoside hydrolase 15-related
CU254_RS15460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CU254_RS15465	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CU254_RS15475	COG0306	phosphate transporter
CU254_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS15545	COG2259	Doxx family
CU254_RS15555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CU254_RS15565	COG0531	amino acid
CU254_RS15580	COG2318	DinB family
CU254_RS15630	COG2890	protein-(glutamine-N5) methyltransferase activity
CU254_RS15645	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CU254_RS15650	COG0778	Nitroreductase
CU254_RS15655	COG1309	transcriptional regulator
CU254_RS15675	COG2814	Major facilitator Superfamily
CU254_RS15685	COG1733	regulation of RNA biosynthetic process
CU254_RS15695	COG0604	alcohol dehydrogenase
CU254_RS15710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS15715	COG0477	Major facilitator Superfamily
CU254_RS15740	COG1335	isochorismatase
CU254_RS15745	COG0596	Alpha beta hydrolase
CU254_RS15750	COG2309	aminopeptidase activity
CU254_RS15795	COG0243	molybdopterin cofactor binding
CU254_RS15810	COG0438	transferase activity, transferring glycosyl groups
CU254_RS15835	COG2192	nodulation
CU254_RS15840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CU254_RS15845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CU254_RS15845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CU254_RS15850	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS15860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU254_RS15885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CU254_RS15890	COG0859	PFAM glycosyl transferase family 9
CU254_RS15895	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS15920	COG0640	Transcriptional regulator
CU254_RS15935	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CU254_RS15945	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CU254_RS15970	COG0583	DNA-binding transcription factor activity
CU254_RS15990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS16025	COG2801	Transposase and inactivated derivatives
CU254_RS16045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU254_RS16050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU254_RS16060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU254_RS16070	COG0667	Aldo Keto reductase
CU254_RS16130	COG2197	response regulator
CU254_RS16140	COG2814	Major facilitator Superfamily
CU254_RS16160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS16200	COG0617	tRNA 3'-terminal CCA addition
CU254_RS16200	COG0517	IMP dehydrogenase activity
CU254_RS16200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CU254_RS16250	COG1733	regulation of RNA biosynthetic process
CU254_RS16260	COG1309	transcriptional regulator
CU254_RS16270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CU254_RS16285	COG1132	(ABC) transporter
CU254_RS16290	COG1132	(ABC) transporter
CU254_RS16300	COG0515	serine threonine protein kinase
CU254_RS16325	COG1486	melibiose metabolic process
CU254_RS16330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_RS16335	COG0395	ABC-type sugar transport system, permease component
CU254_RS16350	COG0673	inositol 2-dehydrogenase activity
CU254_RS16355	COG1349	DNA-binding transcription factor activity
CU254_RS16360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CU254_RS16370	COG0191	fructose-bisphosphate aldolase activity
CU254_RS16390	COG0402	S-adenosylhomocysteine deaminase activity
CU254_RS16395	COG1802	Transcriptional regulator
CU254_RS16400	COG1228	amidohydrolase
CU254_RS16405	COG1228	amidohydrolase
CU254_RS16410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_RS16430	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS16445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_RS16455	COG0601	transmembrane transport
CU254_RS16465	COG4608	Belongs to the ABC transporter superfamily
CU254_RS16485	COG3291	Pkd domain containing protein
CU254_RS16485	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CU254_RS16530	COG0693	protein deglycase activity
CU254_RS16570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CU254_RS16595	COG0010	Belongs to the arginase family
CU254_RS16600	COG0765	amino acid transport
CU254_RS16615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CU254_RS16625	COG0277	FAD linked oxidase domain protein
CU254_RS16640	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CU254_RS16655	COG0243	molybdopterin cofactor binding
CU254_RS16690	COG0366	Alpha amylase catalytic
CU254_RS16700	COG1175	transmembrane transport
CU254_RS16710	COG1609	Transcriptional regulator
CU254_RS16735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS16745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CU254_RS16780	COG0748	coenzyme F420 binding
CU254_RS16795	COG0604	alcohol dehydrogenase
CU254_RS16800	COG1846	Transcriptional regulator
CU254_RS16835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_RS16840	COG0601	transmembrane transport
CU254_RS16855	COG1609	Transcriptional regulator
CU254_RS16920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_RS16925	COG1414	Transcriptional regulator
CU254_RS16955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS17010	COG0596	Alpha beta hydrolase
CU254_RS17015	COG2807	transmembrane transport
CU254_RS17050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU254_RS17060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_RS17080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS17120	COG0300	oxidoreductase activity
CU254_RS17125	COG0129	dihydroxy-acid dehydratase activity
CU254_RS17140	COG0395	ABC-type sugar transport system, permease component
CU254_RS17145	COG1175	transmembrane transport
CU254_RS17155	COG1609	Transcriptional regulator
CU254_RS17160	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_RS17195	COG3794	PFAM blue (type 1) copper domain protein
CU254_RS17285	COG0477	Major facilitator Superfamily
CU254_RS17325	COG0640	Transcriptional regulator
CU254_RS17340	COG0477	Major facilitator Superfamily
CU254_RS17360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CU254_RS17375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU254_RS17380	COG2226	methyltransferase
CU254_RS17390	COG1410	methionine synthase
CU254_RS17390	COG0646	methionine synthase
CU254_RS17400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CU254_RS17455	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS17495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CU254_RS17555	COG1113	amino acid transport
CU254_RS17560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU254_RS17570	COG1414	Transcriptional regulator
CU254_RS17600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS17605	COG0686	Belongs to the AlaDH PNT family
CU254_RS17610	COG0280	phosphate acetyltransferase
CU254_RS17635	COG0583	DNA-binding transcription factor activity
CU254_RS17660	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
CU254_RS17670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS17675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS17700	COG4172	Belongs to the ABC transporter superfamily
CU254_RS17705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_RS17710	COG0601	transmembrane transport
CU254_RS17715	COG0747	negative chemotaxis
CU254_RS17725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU254_RS17740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU254_RS17750	COG0681	Belongs to the peptidase S26 family
CU254_RS17760	COG2327	Polysaccharide pyruvyl transferase
CU254_RS17765	COG0438	transferase activity, transferring glycosyl groups
CU254_RS17775	COG0438	transferase activity, transferring glycosyl groups
CU254_RS17785	COG0438	transferase activity, transferring glycosyl groups
CU254_RS17795	COG1215	transferase activity, transferring glycosyl groups
CU254_RS17805	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CU254_RS17810	COG1376	ErfK ybiS ycfS ynhG family protein
CU254_RS17825	COG4638	Rieske (2fe-2S)
CU254_RS17870	COG0656	L-ascorbic acid biosynthetic process
CU254_RS17885	COG1253	flavin adenine dinucleotide binding
CU254_RS17915	COG2267	carboxylic ester hydrolase activity
CU254_RS17920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU254_RS17925	COG0583	DNA-binding transcription factor activity
CU254_RS17930	COG3572	ergothioneine biosynthetic process
CU254_RS17935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CU254_RS17940	COG0121	glutamine amidotransferase
CU254_RS17945	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CU254_RS17970	COG2837	iron assimilation
CU254_RS17975	COG3511	phospholipase C
CU254_RS17980	COG2801	Transposase and inactivated derivatives
CU254_RS17985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CU254_RS17990	COG0791	NLP P60 protein
CU254_RS17990	COG3883	PFAM NLP P60 protein
CU254_RS18005	COG0714	Associated with various cellular activities
CU254_RS18015	COG2304	oxidoreductase activity
CU254_RS18030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CU254_RS18045	COG2205	protein histidine kinase activity
CU254_RS18055	COG0477	Major facilitator Superfamily
CU254_RS18065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CU254_RS18080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CU254_RS18090	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
CU254_RS18100	COG0789	Transcriptional regulator
CU254_RS18105	COG0215	cysteine-tRNA ligase activity
CU254_RS18110	COG0488	(ABC) transporter
CU254_RS18125	COG2814	Major facilitator Superfamily
CU254_RS18130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CU254_RS18145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_RS18150	COG0140	phosphoribosyl-ATP diphosphatase activity
CU254_RS18155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CU254_RS18160	COG1192	Involved in chromosome partitioning
CU254_RS18175	COG0517	IMP dehydrogenase activity
CU254_RS18175	COG1994	Peptidase M50
CU254_RS18195	COG1222	aaa ATPase
CU254_RS18235	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CU254_RS18240	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CU254_RS18245	COG4941	Belongs to the sigma-70 factor family
CU254_RS18250	COG3795	YCII-related domain
CU254_RS18260	COG1597	lipid kinase activity
CU254_RS18265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CU254_RS18290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CU254_RS18300	COG1597	lipid kinase activity
CU254_RS18315	COG4552	Acetyltransferase involved in intracellular survival and related
CU254_RS18325	COG4552	Acetyltransferase involved in intracellular survival and related
CU254_RS18365	COG1309	transcriptional regulator
CU254_RS18370	COG4941	Belongs to the sigma-70 factor family
CU254_RS18380	COG4221	oxidoreductase activity
CU254_RS18385	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS18445	COG2814	Major facilitator Superfamily
CU254_RS18455	COG0657	acetylesterase activity
CU254_RS18460	COG0667	Aldo Keto reductase
CU254_RS18465	COG1063	alcohol dehydrogenase
CU254_RS18470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CU254_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS18495	COG0601	transmembrane transport
CU254_RS18500	COG0444	Belongs to the ABC transporter superfamily
CU254_RS18505	COG4172	Belongs to the ABC transporter superfamily
CU254_RS18530	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS18535	COG1960	acyl-CoA dehydrogenase activity
CU254_RS18570	COG0038	chloride channel
CU254_RS18575	COG5000	phosphorelay sensor kinase activity
CU254_RS18575	COG5002	protein histidine kinase activity
CU254_RS18580	COG0745	RESPONSE REGULATOR receiver
CU254_RS18585	COG0235	Class ii aldolase
CU254_RS18590	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS18610	COG1414	Transcriptional regulator
CU254_RS18615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS18635	COG1414	Transcriptional regulator
CU254_RS18650	COG2271	Major facilitator Superfamily
CU254_RS18660	COG1309	transcriptional regulator
CU254_RS18675	COG0596	Alpha beta hydrolase
CU254_RS18680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_RS18685	COG0183	Belongs to the thiolase family
CU254_RS18690	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CU254_RS18700	COG1960	acyl-CoA dehydrogenase activity
CU254_RS18710	COG1960	acyl-CoA dehydrogenase activity
CU254_RS18720	COG0154	amidase activity
CU254_RS18725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS18755	COG3511	phospholipase C
CU254_RS18760	COG3511	phospholipase C
CU254_RS18785	COG1088	dTDP-glucose 4,6-dehydratase activity
CU254_RS18790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU254_RS18800	COG2205	protein histidine kinase activity
CU254_RS18810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU254_RS18820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CU254_RS18835	COG0477	Major facilitator Superfamily
CU254_RS18840	COG1609	Transcriptional regulator
CU254_RS18855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CU254_RS18860	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS18895	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS18910	COG3268	Saccharopine dehydrogenase
CU254_RS18940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU254_RS18950	COG0463	Glycosyl transferase, family 2
CU254_RS18960	COG0640	Transcriptional regulator
CU254_RS18970	COG2814	Major facilitator Superfamily
CU254_RS18975	COG0583	DNA-binding transcription factor activity
CU254_RS18990	COG1435	thymidine kinase activity
CU254_RS19020	COG0789	Transcriptional regulator
CU254_RS19030	COG4974	Belongs to the 'phage' integrase family
CU254_RS19035	COG4221	oxidoreductase activity
CU254_RS19045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS19050	COG1309	transcriptional regulator
CU254_RS19055	COG1960	acyl-CoA dehydrogenase activity
CU254_RS19060	COG2226	methyltransferase
CU254_RS19065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS19075	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU254_RS19080	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CU254_RS19100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU254_RS19115	COG0596	Alpha beta hydrolase
CU254_RS19120	COG3795	YCII-related domain
CU254_RS19180	COG0655	NAD(P)H dehydrogenase (quinone) activity
CU254_RS19195	COG2318	DinB family
CU254_RS19210	COG1309	transcriptional regulator
CU254_RS19215	COG1357	PFAM Pentapeptide repeats (8 copies)
CU254_RS19340	COG1136	(ABC) transporter
CU254_RS19355	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS19360	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CU254_RS19415	COG0477	Major facilitator Superfamily
CU254_RS19435	COG0667	Aldo Keto reductase
CU254_RS19455	COG1506	peptidase
CU254_RS19455	COG0823	Involved in the tonB-independent uptake of proteins
CU254_RS19455	COG4946	Tricorn protease homolog
CU254_RS19460	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU254_RS19495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_RS19500	COG0601	transmembrane transport
CU254_RS19505	COG4166	transmembrane transport
CU254_RS19515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_RS19535	COG3537	Alpha-1,2-mannosidase
CU254_RS19555	COG0667	Aldo Keto reductase
CU254_RS19570	COG1846	Transcriptional regulator
CU254_RS19580	COG0039	L-malate dehydrogenase activity
CU254_RS19605	COG3321	synthase
CU254_RS19605	COG0604	alcohol dehydrogenase
CU254_RS19615	COG3979	chitinase
CU254_RS19620	COG2271	Major facilitator Superfamily
CU254_RS19625	COG0339	signal peptide processing
CU254_RS19635	COG1968	undecaprenyl-diphosphatase activity
CU254_RS19640	COG0667	Aldo Keto reductase
CU254_RS19655	COG4941	Belongs to the sigma-70 factor family
CU254_RS19695	COG1309	transcriptional regulator
CU254_RS19700	COG3246	L-lysine catabolic process to acetate
CU254_RS19705	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS19720	COG0601	transmembrane transport
CU254_RS19735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU254_RS19770	COG3285	dna ligase
CU254_RS19770	COG1793	dna ligase
CU254_RS19840	COG4221	oxidoreductase activity
CU254_RS19860	COG3960	tartronate-semialdehyde synthase activity
CU254_RS19865	COG2084	Dehydrogenase
CU254_RS19870	COG3622	Belongs to the hyi family
CU254_RS19880	COG2850	peptidyl-arginine hydroxylation
CU254_RS19890	COG1802	Transcriptional regulator
CU254_RS19895	COG1017	nitric oxide dioxygenase activity
CU254_RS19895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CU254_RS19900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU254_RS19910	COG0277	FAD linked oxidase domain protein
CU254_RS19925	COG0583	DNA-binding transcription factor activity
CU254_RS19935	COG1053	succinate dehydrogenase
CU254_RS19940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CU254_RS19955	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS19970	COG0583	DNA-binding transcription factor activity
CU254_RS19975	COG2072	flavoprotein involved in K transport
CU254_RS20005	COG0531	amino acid
CU254_RS20030	COG4172	Belongs to the ABC transporter superfamily
CU254_RS20035	COG0747	negative chemotaxis
CU254_RS20045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_RS20060	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS20085	COG2182	Extracellular solute-binding protein
CU254_RS20090	COG1175	transmembrane transport
CU254_RS20095	COG0395	ABC-type sugar transport system, permease component
CU254_RS20100	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_RS20135	COG0009	L-threonylcarbamoyladenylate synthase
CU254_RS20165	COG0456	acetyltransferase
CU254_RS20170	COG1063	alcohol dehydrogenase
CU254_RS20180	COG0778	Nitroreductase
CU254_RS20180	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CU254_RS20190	COG0702	epimerase
CU254_RS20230	COG1716	ATPase activity
CU254_RS20260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU254_RS20265	COG1024	Enoyl-CoA hydratase
CU254_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS20280	COG1309	transcriptional regulator
CU254_RS20285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_RS20290	COG1648	precorrin-2 dehydrogenase activity
CU254_RS20290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CU254_RS20295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CU254_RS20300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CU254_RS20305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CU254_RS20310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CU254_RS20320	COG0254	rRNA binding
CU254_RS20330	COG0523	cobalamin synthesis protein
CU254_RS20340	COG2814	Major facilitator Superfamily
CU254_RS20355	COG2211	Major facilitator Superfamily
CU254_RS20360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS20385	COG1414	Transcriptional regulator
CU254_RS20395	COG1228	amidohydrolase
CU254_RS20425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS20435	COG1116	anion transmembrane transporter activity
CU254_RS20440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU254_RS20450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS20465	COG1132	(ABC) transporter
CU254_RS20470	COG1132	(ABC) transporter
CU254_RS20480	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CU254_RS20490	COG0488	(ABC) transporter
CU254_RS20500	COG1024	Enoyl-CoA hydratase
CU254_RS20530	COG1937	Protein conserved in bacteria
CU254_RS20545	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS20560	COG0405	Gamma-glutamyltransferase
CU254_RS20635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CU254_RS20640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_RS20645	COG1414	Transcriptional regulator
CU254_RS20650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU254_RS20655	COG0022	dehydrogenase e1 component
CU254_RS20660	COG4689	acetoacetate decarboxylase
CU254_RS20665	COG0477	Major facilitator Superfamily
CU254_RS20690	COG2814	Major facilitator Superfamily
CU254_RS20715	COG2271	Major facilitator Superfamily
CU254_RS20765	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS20810	COG2271	Major facilitator Superfamily
CU254_RS20830	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CU254_RS20840	COG0577	efflux transmembrane transporter activity
CU254_RS20840	COG1136	(ABC) transporter
CU254_RS20850	COG1609	Transcriptional regulator
CU254_RS20855	COG1175	transmembrane transport
CU254_RS20880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_RS20890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_RS20895	COG2301	Belongs to the HpcH HpaI aldolase family
CU254_RS20900	COG0477	Major facilitator Superfamily
CU254_RS20915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS20920	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS20930	COG0604	alcohol dehydrogenase
CU254_RS20960	COG1733	regulation of RNA biosynthetic process
CU254_RS20970	COG0671	phosphoesterase, PA-phosphatase related
CU254_RS20990	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_RS20995	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU254_RS21000	COG1595	DNA-templated transcription, initiation
CU254_RS21025	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU254_RS21030	COG0640	Transcriptional regulator
CU254_RS21035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU254_RS21040	COG1285	pathogenesis
CU254_RS21050	COG1116	anion transmembrane transporter activity
CU254_RS21055	COG2814	Major facilitator Superfamily
CU254_RS21090	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CU254_RS21105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CU254_RS21140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CU254_RS21150	COG3250	beta-galactosidase activity
CU254_RS21160	COG1695	Transcriptional regulator
CU254_RS21165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS21220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS21235	COG1793	dna ligase
CU254_RS21235	COG3285	dna ligase
CU254_RS21300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CU254_RS21315	COG0515	serine threonine protein kinase
CU254_RS21315	COG2815	serine threonine protein kinase
CU254_RS21340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CU254_RS21350	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CU254_RS21375	COG0028	Belongs to the TPP enzyme family
CU254_RS21415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS21450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CU254_RS21455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU254_RS21460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU254_RS21465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU254_RS21470	COG1862	Preprotein translocase
CU254_RS21475	COG2255	four-way junction helicase activity
CU254_RS21480	COG0632	four-way junction helicase activity
CU254_RS21485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CU254_RS21500	COG0217	transcriptional regulatory protein
CU254_RS21505	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CU254_RS21510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CU254_RS21525	COG2271	Major facilitator Superfamily
CU254_RS21535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS21545	COG3284	Transcriptional regulator
CU254_RS21550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS21585	COG1396	sequence-specific DNA binding
CU254_RS21610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CU254_RS21610	COG3608	succinylglutamate desuccinylase aspartoacylase
CU254_RS21620	COG0438	transferase activity, transferring glycosyl groups
CU254_RS21625	COG1560	Kdo2-lipid A biosynthetic process
CU254_RS21635	COG1846	Transcriptional regulator
CU254_RS21650	COG0778	Nitroreductase
CU254_RS21655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CU254_RS21680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU254_RS21690	COG2124	cytochrome p450
CU254_RS21700	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS21705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU254_RS21710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU254_RS21725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU254_RS21745	COG3321	synthase
CU254_RS21745	COG0604	alcohol dehydrogenase
CU254_RS21765	COG2124	cytochrome p450
CU254_RS21805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS21825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU254_RS21845	COG0300	oxidoreductase activity
CU254_RS21865	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS21885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CU254_RS21890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CU254_RS21895	COG1024	Enoyl-CoA hydratase
CU254_RS21895	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS21905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CU254_RS21920	COG0129	dihydroxy-acid dehydratase activity
CU254_RS21925	COG0762	integral membrane protein
CU254_RS21940	COG1335	isochorismatase
CU254_RS21945	COG1846	Transcriptional regulator
CU254_RS21950	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS21955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU254_RS21965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CU254_RS21975	COG0366	Alpha amylase catalytic
CU254_RS21980	COG0366	Alpha amylase catalytic
CU254_RS21990	COG2378	regulation of single-species biofilm formation
CU254_RS22045	COG1802	Transcriptional regulator
CU254_RS22100	COG1088	dTDP-glucose 4,6-dehydratase activity
CU254_RS22115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU254_RS22130	COG0714	Associated with various cellular activities
CU254_RS22140	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CU254_RS22155	COG0346	lactoylglutathione lyase activity
CU254_RS22165	COG5492	domain, Protein
CU254_RS22180	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_RS22185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_RS22190	COG1414	Transcriptional regulator
CU254_RS22195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU254_RS22245	COG1160	GTP binding
CU254_RS22250	COG0204	Acyl-transferase
CU254_RS22255	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CU254_RS22270	COG0475	glutathione-regulated potassium exporter activity
CU254_RS22275	COG2936	dipeptidyl-peptidase activity
CU254_RS22285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CU254_RS22310	COG0494	nUDIX hydrolase
CU254_RS22315	COG0504	CTP synthase activity
CU254_RS22320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CU254_RS22330	COG1802	Transcriptional regulator
CU254_RS22335	COG1953	Uracil, thiamine, allantoin
CU254_RS22390	COG0647	UMP catabolic process
CU254_RS22420	COG2094	Belongs to the DNA glycosylase MPG family
CU254_RS22425	COG0165	Argininosuccinate lyase
CU254_RS22430	COG0137	argininosuccinate synthase activity
CU254_RS22435	COG1438	arginine binding
CU254_RS22445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU254_RS22450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CU254_RS22455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CU254_RS22460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CU254_RS22480	COG0072	phenylalanine-tRNA ligase activity
CU254_RS22480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU254_RS22485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CU254_RS22490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_RS22495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CU254_RS22500	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CU254_RS22525	COG0251	oxidation-reduction process
CU254_RS22545	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CU254_RS22550	COG2610	gluconate transmembrane transporter activity
CU254_RS22555	COG2706	6-phosphogluconolactonase activity
CU254_RS22565	COG1175	transmembrane transport
CU254_RS22570	COG0395	ABC-type sugar transport system, permease component
CU254_RS22580	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS22585	COG4565	transcriptional regulatory protein
CU254_RS22590	COG3290	protein histidine kinase activity
CU254_RS22595	COG1301	dicarboxylic acid transport
CU254_RS22600	COG1733	regulation of RNA biosynthetic process
CU254_RS22625	COG0328	RNA-DNA hybrid ribonuclease activity
CU254_RS22640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS22660	COG0328	RNA-DNA hybrid ribonuclease activity
CU254_RS22670	COG3012	SEC-C Motif Domain Protein
CU254_RS22675	COG3250	beta-galactosidase activity
CU254_RS22680	COG2272	Belongs to the type-B carboxylesterase lipase family
CU254_RS22685	COG0025	NhaP-type Na H and K H
CU254_RS22690	COG0406	alpha-ribazole phosphatase activity
CU254_RS22715	COG1070	Carbohydrate kinase
CU254_RS22720	COG1609	Transcriptional regulator
CU254_RS22735	COG0823	Involved in the tonB-independent uptake of proteins
CU254_RS22735	COG1506	peptidase
CU254_RS22735	COG4946	Tricorn protease homolog
CU254_RS22745	COG1131	(ABC) transporter
CU254_RS22755	COG1024	Enoyl-CoA hydratase
CU254_RS22790	COG1131	(ABC) transporter
CU254_RS22820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CU254_RS22825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU254_RS22825	COG0237	dephospho-CoA kinase activity
CU254_RS22845	COG0539	negative regulation of cytoplasmic translation
CU254_RS22850	COG2226	methyltransferase
CU254_RS22865	COG1511	domain protein
CU254_RS22980	COG1335	isochorismatase
CU254_RS22990	COG1285	pathogenesis
CU254_RS23005	COG2909	trisaccharide binding
CU254_RS23015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CU254_RS23020	COG2197	response regulator
CU254_RS23055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CU254_RS23060	COG0163	prenyltransferase activity
CU254_RS23090	COG0300	oxidoreductase activity
CU254_RS23095	COG2409	Drug exporters of the RND superfamily
CU254_RS23100	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS23140	COG0612	Peptidase, M16
CU254_RS23150	COG1132	(ABC) transporter
CU254_RS23185	COG4585	Histidine kinase
CU254_RS23205	COG1414	Transcriptional regulator
CU254_RS23220	COG0402	S-adenosylhomocysteine deaminase activity
CU254_RS23240	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CU254_RS23240	COG1672	PFAM Archaeal ATPase
CU254_RS23250	COG0667	Aldo Keto reductase
CU254_RS23265	COG1687	branched-chain amino acid
CU254_RS23270	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CU254_RS23275	COG1522	sequence-specific DNA binding
CU254_RS23280	COG0604	alcohol dehydrogenase
CU254_RS23280	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS23280	COG3321	synthase
CU254_RS23290	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS23345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CU254_RS23360	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CU254_RS23390	COG0714	Associated with various cellular activities
CU254_RS23405	COG1053	succinate dehydrogenase
CU254_RS23415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_RS23425	COG2072	flavoprotein involved in K transport
CU254_RS23430	COG0346	lactoylglutathione lyase activity
CU254_RS23445	COG3631	Ketosteroid isomerase-related protein
CU254_RS23460	COG1414	Transcriptional regulator
CU254_RS23465	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS23480	COG3546	catalase activity
CU254_RS23485	COG0723	plastoquinol--plastocyanin reductase activity
CU254_RS23510	COG1309	transcriptional regulator
CU254_RS23515	COG0604	alcohol dehydrogenase
CU254_RS23520	COG1414	Transcriptional regulator
CU254_RS23525	COG0247	lactate metabolic process
CU254_RS23525	COG0277	FAD linked oxidase domain protein
CU254_RS23530	COG1454	alcohol dehydrogenase
CU254_RS23535	COG0477	Major facilitator Superfamily
CU254_RS23560	COG1659	Linocin_M18 bacteriocin protein
CU254_RS23585	COG0437	4 iron, 4 sulfur cluster binding
CU254_RS23590	COG3383	formate dehydrogenase (NAD+) activity
CU254_RS23590	COG0243	molybdopterin cofactor binding
CU254_RS23595	COG0243	molybdopterin cofactor binding
CU254_RS23595	COG3383	formate dehydrogenase (NAD+) activity
CU254_RS23615	COG0709	Synthesizes selenophosphate from selenide and ATP
CU254_RS23650	COG0651	ATP synthesis coupled electron transport
CU254_RS23695	COG0778	Nitroreductase
CU254_RS23695	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
CU254_RS23720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU254_RS23725	COG1376	ErfK ybiS ycfS ynhG family protein
CU254_RS23740	COG1230	cation diffusion facilitator family transporter
CU254_RS23745	COG0739	heme binding
CU254_RS23785	COG2855	membrane
CU254_RS23795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS23800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS23805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS23830	COG0604	alcohol dehydrogenase
CU254_RS23830	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS23830	COG3321	synthase
CU254_RS23845	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CU254_RS23850	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CU254_RS23865	COG2267	carboxylic ester hydrolase activity
CU254_RS23880	COG1309	transcriptional regulator
CU254_RS23890	COG2030	dehydratase
CU254_RS23895	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS23900	COG1024	Enoyl-CoA hydratase
CU254_RS23910	COG0183	Belongs to the thiolase family
CU254_RS23920	COG1960	acyl-CoA dehydrogenase activity
CU254_RS23925	COG1024	Enoyl-CoA hydratase
CU254_RS23930	COG1960	acyl-CoA dehydrogenase activity
CU254_RS23935	COG1960	acyl-CoA dehydrogenase activity
CU254_RS23940	COG1960	acyl-CoA dehydrogenase activity
CU254_RS23960	COG1309	transcriptional regulator
CU254_RS23965	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS23975	COG0183	Belongs to the thiolase family
CU254_RS24010	COG1309	transcriptional regulator
CU254_RS24020	COG2226	methyltransferase
CU254_RS24030	COG0583	DNA-binding transcription factor activity
CU254_RS24060	COG0581	inorganic phosphate transmembrane transporter activity
CU254_RS24070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CU254_RS24075	COG2346	COG2346, Truncated hemoglobins
CU254_RS24080	COG1733	regulation of RNA biosynthetic process
CU254_RS24125	COG4638	Rieske (2fe-2S)
CU254_RS24130	COG0583	DNA-binding transcription factor activity
CU254_RS24140	COG3485	protocatechuate 3,4-dioxygenase
CU254_RS24145	COG4829	muconolactone delta-isomerase
CU254_RS24150	COG1136	(ABC) transporter
CU254_RS24155	COG1136	(ABC) transporter
CU254_RS24165	COG1024	Enoyl-CoA hydratase
CU254_RS24180	COG1960	acyl-CoA dehydrogenase activity
CU254_RS24185	COG1960	acyl-CoA dehydrogenase activity
CU254_RS24190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_RS24215	COG0583	DNA-binding transcription factor activity
CU254_RS24255	COG2267	carboxylic ester hydrolase activity
CU254_RS24270	COG0745	RESPONSE REGULATOR receiver
CU254_RS24275	COG2205	protein histidine kinase activity
CU254_RS24285	COG1309	transcriptional regulator
CU254_RS24290	COG0644	oxidoreductase
CU254_RS24315	COG0514	ATP-dependent DNA helicase (RecQ)
CU254_RS24330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CU254_RS24340	COG0542	response to heat
CU254_RS24345	COG0667	Aldo Keto reductase
CU254_RS24350	COG0494	nUDIX hydrolase
CU254_RS24365	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CU254_RS24370	COG1846	Transcriptional regulator
CU254_RS24370	COG1940	carbohydrate kinase activity
CU254_RS24395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS24425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CU254_RS24435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU254_RS24445	COG0640	Transcriptional regulator
CU254_RS24450	COG0768	penicillin binding
CU254_RS24455	COG1113	amino acid transport
CU254_RS24460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CU254_RS24480	COG0640	Transcriptional regulator
CU254_RS24500	COG1799	cell septum assembly
CU254_RS24505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CU254_RS24510	COG1496	oxidoreductase activity
CU254_RS24515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CU254_RS24525	COG1595	DNA-templated transcription, initiation
CU254_RS24540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU254_RS24555	COG2318	DinB family
CU254_RS24570	COG0702	epimerase
CU254_RS24580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CU254_RS24585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU254_RS24595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CU254_RS24600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CU254_RS24620	COG0768	penicillin binding
CU254_RS24630	COG0275	rRNA processing
CU254_RS24635	COG2001	Belongs to the MraZ family
CU254_RS24660	COG0714	Associated with various cellular activities
CU254_RS24670	COG1305	Transglutaminase-like
CU254_RS24680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CU254_RS24690	COG1192	Involved in chromosome partitioning
CU254_RS24695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CU254_RS24710	COG0167	dihydroorotate dehydrogenase activity
CU254_RS24725	COG1842	Phage shock protein A
CU254_RS24730	COG1396	sequence-specific DNA binding
CU254_RS24735	COG1546	Belongs to the CinA family
CU254_RS24735	COG1058	Belongs to the CinA family
CU254_RS24745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU254_RS24750	COG0464	growth
CU254_RS24760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CU254_RS24770	COG1674	ftsk spoiiie
CU254_RS24785	COG0655	NAD(P)H dehydrogenase (quinone) activity
CU254_RS24795	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU254_RS24800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_RS24820	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CU254_RS24845	COG3214	Protein conserved in bacteria
CU254_RS24870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CU254_RS24875	COG0612	Peptidase, M16
CU254_RS24880	COG1185	polyribonucleotide nucleotidyltransferase activity
CU254_RS24885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CU254_RS24890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CU254_RS24905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CU254_RS24915	COG0384	phenazine biosynthesis protein PhzF
CU254_RS24930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CU254_RS24945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CU254_RS24970	COG0779	Required for maturation of 30S ribosomal subunits
CU254_RS25005	COG3851	Histidine kinase
CU254_RS25010	COG2197	response regulator
CU254_RS25035	COG1053	succinate dehydrogenase
CU254_RS25035	COG3976	FMN-binding domain protein
CU254_RS25045	COG1846	Transcriptional regulator
CU254_RS25070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CU254_RS25080	COG1733	regulation of RNA biosynthetic process
CU254_RS25090	COG0745	RESPONSE REGULATOR receiver
CU254_RS25095	COG5002	protein histidine kinase activity
CU254_RS25100	COG1316	TRANSCRIPTIONal
CU254_RS25115	COG2814	Major facilitator Superfamily
CU254_RS25135	COG0583	DNA-binding transcription factor activity
CU254_RS25180	COG1674	ftsk spoiiie
CU254_RS25200	COG0464	growth
CU254_RS25265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_RS25285	COG1609	Transcriptional regulator
CU254_RS25295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_RS25300	COG3104	oligopeptide transport
CU254_RS25315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_RS25315	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CU254_RS25320	COG1126	abc transporter atp-binding protein
CU254_RS25325	COG0765	amino acid transport
CU254_RS25350	COG2271	Major facilitator Superfamily
CU254_RS25360	COG3340	Belongs to the peptidase S51 family
CU254_RS25365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_RS25370	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CU254_RS25395	COG1609	Transcriptional regulator
CU254_RS25410	COG2160	L-arabinose isomerase activity
CU254_RS25415	COG4213	ABC transporter substrate-binding protein
CU254_RS25420	COG1129	ABC transporter
CU254_RS25425	COG4214	carbohydrate transport
CU254_RS25475	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_RS25485	COG4977	sequence-specific DNA binding
CU254_RS25495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU254_RS25540	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU254_RS25560	COG0604	alcohol dehydrogenase
CU254_RS25560	COG3321	synthase
CU254_RS25565	COG1309	transcriptional regulator
CU254_RS25580	COG2423	ornithine cyclodeaminase activity
CU254_RS25590	COG0477	Major facilitator Superfamily
CU254_RS25595	COG1309	transcriptional regulator
CU254_RS25600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CU254_RS25605	COG1082	Xylose isomerase domain protein TIM barrel
CU254_RS25605	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CU254_RS25650	COG0596	Alpha beta hydrolase
CU254_RS25680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CU254_RS25700	COG0789	Transcriptional regulator
CU254_RS25705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU254_RS25715	COG3973	AAA domain
CU254_RS25740	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS25745	COG2084	Dehydrogenase
CU254_RS25755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU254_RS25760	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CU254_RS25765	COG2080	2 iron, 2 sulfur cluster binding
CU254_RS25790	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS25850	COG1793	dna ligase
CU254_RS25850	COG3285	dna ligase
CU254_RS25925	COG1280	lysine exporter protein (LysE YggA)
CU254_RS25965	COG3345	alpha-galactosidase
CU254_RS25995	COG0477	Major facilitator Superfamily
CU254_RS26075	COG3246	L-lysine catabolic process to acetate
CU254_RS26080	COG0405	Gamma-glutamyltransferase
CU254_RS26125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CU254_RS26170	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS26230	COG1401	restriction endodeoxyribonuclease activity
CU254_RS26235	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CU254_RS26245	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CU254_RS26290	COG4106	trans-aconitate 2-methyltransferase activity
CU254_RS26305	COG1595	DNA-templated transcription, initiation
CU254_RS26325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CU254_RS26335	COG2197	response regulator
CU254_RS26340	COG4585	Histidine kinase
CU254_RS26350	COG1131	(ABC) transporter
CU254_RS26355	COG0423	glycine-tRNA ligase activity
CU254_RS26390	COG0701	Predicted permease
CU254_RS26400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CU254_RS26405	COG1381	Involved in DNA repair and RecF pathway recombination
CU254_RS26430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CU254_RS26445	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CU254_RS26455	COG0537	adenosine 5'-monophosphoramidase activity
CU254_RS26465	COG0484	heat shock protein binding
CU254_RS26525	COG2205	protein histidine kinase activity
CU254_RS26530	COG0745	RESPONSE REGULATOR receiver
CU254_RS26535	COG1953	Uracil, thiamine, allantoin
CU254_RS26545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU254_RS26635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU254_RS26655	COG0604	alcohol dehydrogenase
CU254_RS26665	COG0531	amino acid
CU254_RS26685	COG0481	GTPase activity
CU254_RS26690	COG2226	methyltransferase
CU254_RS26705	COG0268	Binds directly to 16S ribosomal RNA
CU254_RS26715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CU254_RS26720	COG2333	competence protein COMEC
CU254_RS26720	COG0658	competence protein
CU254_RS26725	COG1555	photosystem II stabilization
CU254_RS26745	COG1307	EDD domain protein, DegV family
CU254_RS26750	COG2755	lipolytic protein G-D-S-L family
CU254_RS26755	COG0406	alpha-ribazole phosphatase activity
CU254_RS26760	COG0799	negative regulation of ribosome biogenesis
CU254_RS26765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CU254_RS26775	COG0477	Major facilitator Superfamily
CU254_RS26780	COG0018	arginyl-trna synthetase
CU254_RS26785	COG1309	transcriptional regulator
CU254_RS26790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU254_RS26795	COG1960	acyl-CoA dehydrogenase activity
CU254_RS26800	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS26805	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS26820	COG1309	transcriptional regulator
CU254_RS26830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CU254_RS26840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CU254_RS26845	COG1530	ribonuclease E activity
CU254_RS26845	COG1530	ribonuclease E activity
CU254_RS26865	COG1131	(ABC) transporter
CU254_RS26890	COG0105	UTP biosynthetic process
CU254_RS26915	COG0285	dihydrofolate synthase activity
CU254_RS26930	COG0525	valine-tRNA ligase activity
CU254_RS26945	COG0477	Major facilitator Superfamily
CU254_RS26955	COG1316	TRANSCRIPTIONal
CU254_RS26960	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS27000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CU254_RS27010	COG1309	transcriptional regulator
CU254_RS27025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CU254_RS27030	COG0740	serine-type endopeptidase activity
CU254_RS27035	COG0740	serine-type endopeptidase activity
CU254_RS27040	COG0544	peptidyl-prolyl cis-trans isomerase activity
CU254_RS27045	COG3001	Fructosamine kinase
CU254_RS27050	COG2205	protein histidine kinase activity
CU254_RS27055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_RS27065	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_RS27110	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS27125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU254_RS27130	COG0702	epimerase
CU254_RS27135	COG1733	regulation of RNA biosynthetic process
CU254_RS27145	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CU254_RS27150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CU254_RS27165	COG1785	Belongs to the alkaline phosphatase family
CU254_RS27175	COG1940	carbohydrate kinase activity
CU254_RS27185	COG0017	Asparaginyl-tRNA synthetase
CU254_RS27190	COG1846	Transcriptional regulator
CU254_RS27195	COG0515	serine threonine protein kinase
CU254_RS27195	COG2815	serine threonine protein kinase
CU254_RS27205	COG0784	Response regulator, receiver
CU254_RS27205	COG5002	protein histidine kinase activity
CU254_RS27250	COG0667	Aldo Keto reductase
CU254_RS27305	COG3903	Transcriptional regulator
CU254_RS27305	COG3629	intracellular signal transduction
CU254_RS27330	COG2271	Major facilitator Superfamily
CU254_RS27335	COG0251	oxidation-reduction process
CU254_RS27355	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS27360	COG0583	DNA-binding transcription factor activity
CU254_RS27375	COG2197	response regulator
CU254_RS27380	COG4585	Histidine kinase
CU254_RS27395	COG0456	acetyltransferase
CU254_RS27405	COG1309	transcriptional regulator
CU254_RS27445	COG2814	Major facilitator Superfamily
CU254_RS27460	COG1846	Transcriptional regulator
CU254_RS27485	COG0698	ribose 5-phosphate isomerase
CU254_RS27500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU254_RS27510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CU254_RS27530	COG0668	transmembrane transport
CU254_RS27540	COG0366	Alpha amylase catalytic
CU254_RS27550	COG1278	Cold shock
CU254_RS27580	COG2902	Dehydrogenase
CU254_RS27600	COG1609	Transcriptional regulator
CU254_RS27725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS27730	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS27735	COG2072	flavoprotein involved in K transport
CU254_RS27765	COG3511	phospholipase C
CU254_RS27770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS27775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_RS27785	COG1960	acyl-CoA dehydrogenase activity
CU254_RS27820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU254_RS27850	COG3795	YCII-related domain
CU254_RS27865	COG0009	L-threonylcarbamoyladenylate synthase
CU254_RS27870	COG1285	pathogenesis
CU254_RS27880	COG1937	Protein conserved in bacteria
CU254_RS27915	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS27925	COG4941	Belongs to the sigma-70 factor family
CU254_RS27930	COG0596	Alpha beta hydrolase
CU254_RS27935	COG0596	Alpha beta hydrolase
CU254_RS27940	COG4221	oxidoreductase activity
CU254_RS27950	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CU254_RS27960	COG0657	acetylesterase activity
CU254_RS27985	COG1309	transcriptional regulator
CU254_RS28050	COG0745	RESPONSE REGULATOR receiver
CU254_RS28055	COG0642	Histidine kinase
CU254_RS28060	COG0531	amino acid
CU254_RS28065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU254_RS28105	COG2801	Transposase and inactivated derivatives
CU254_RS28130	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS28135	COG1024	Enoyl-CoA hydratase
CU254_RS28170	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS28180	COG1643	Atp-dependent helicase
CU254_RS28185	COG0475	glutathione-regulated potassium exporter activity
CU254_RS28205	COG1796	DNA polymerase
CU254_RS28205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CU254_RS28215	COG1802	Transcriptional regulator
CU254_RS28250	COG3795	YCII-related domain
CU254_RS28260	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CU254_RS28265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_RS28285	COG1609	Transcriptional regulator
CU254_RS28305	COG2233	PERMEase
CU254_RS28310	COG0163	prenyltransferase activity
CU254_RS28315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CU254_RS28320	COG0523	cobalamin synthesis protein
CU254_RS28330	COG0235	Class ii aldolase
CU254_RS28330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CU254_RS28355	COG1846	Transcriptional regulator
CU254_RS28360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS28365	COG0477	Major facilitator Superfamily
CU254_RS28390	COG1739	Uncharacterized protein family UPF0029
CU254_RS28395	COG0069	glutamate synthase activity
CU254_RS28395	COG0067	glutamate synthase
CU254_RS28395	COG0070	glutamate synthase
CU254_RS28405	COG1228	amidohydrolase
CU254_RS28410	COG0477	Major facilitator Superfamily
CU254_RS28415	COG0583	DNA-binding transcription factor activity
CU254_RS28435	COG3851	Histidine kinase
CU254_RS28440	COG2197	response regulator
CU254_RS28450	COG1492	cobalamin metabolic process
CU254_RS28455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CU254_RS28465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CU254_RS28475	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CU254_RS28490	COG1797	cobyrinic acid a,c-diamide synthase activity
CU254_RS28525	COG0778	Nitroreductase
CU254_RS28565	COG1131	(ABC) transporter
CU254_RS28575	COG1476	TRANSCRIPTIONal
CU254_RS28585	COG3469	chitinase activity
CU254_RS28590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU254_RS28590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU254_RS28595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CU254_RS28635	COG2226	methyltransferase
CU254_RS28650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU254_RS28660	COG0433	COG0433 Predicted ATPase
CU254_RS28665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CU254_RS28720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CU254_RS28760	COG2366	antibiotic biosynthetic process
CU254_RS28775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CU254_RS28805	COG2197	response regulator
CU254_RS28870	COG3033	Beta-eliminating lyase
CU254_RS28890	COG1309	transcriptional regulator
CU254_RS28930	COG0542	response to heat
CU254_RS28945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CU254_RS28950	COG0443	Heat shock 70 kDa protein
CU254_RS28985	COG3321	synthase
CU254_RS28985	COG0604	alcohol dehydrogenase
CU254_RS29015	COG2814	Major facilitator Superfamily
CU254_RS29020	COG0488	(ABC) transporter
CU254_RS29030	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS29080	COG0444	Belongs to the ABC transporter superfamily
CU254_RS29085	COG4608	Belongs to the ABC transporter superfamily
CU254_RS29095	COG4166	transmembrane transport
CU254_RS29100	COG1363	Peptidase, m42
CU254_RS29160	COG2197	response regulator
CU254_RS29170	COG4585	Histidine kinase
CU254_RS29185	COG2124	cytochrome p450
CU254_RS29185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CU254_RS29190	COG1309	transcriptional regulator
CU254_RS29210	COG3842	ATPase activity
CU254_RS29225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU254_RS29260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_RS29265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU254_RS29270	COG0473	3-isopropylmalate dehydrogenase activity
CU254_RS29270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU254_RS29275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU254_RS29280	COG3384	dioxygenase
CU254_RS29285	COG2159	amidohydrolase
CU254_RS29290	COG2368	4-hydroxyphenylacetate
CU254_RS29300	COG0028	Belongs to the TPP enzyme family
CU254_RS29305	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_RS29315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU254_RS29355	COG1335	isochorismatase
CU254_RS29365	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS29375	COG1802	Transcriptional regulator
CU254_RS29380	COG0436	Aminotransferase
CU254_RS29390	COG0477	Major facilitator Superfamily
CU254_RS29395	COG1309	transcriptional regulator
CU254_RS29420	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS29440	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_RS29450	COG3835	regulator
CU254_RS29465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CU254_RS29465	COG2010	Cytochrome c
CU254_RS29470	COG2080	2 iron, 2 sulfur cluster binding
CU254_RS29490	COG0022	dehydrogenase e1 component
CU254_RS29495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU254_RS29505	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_RS29540	COG1131	(ABC) transporter
CU254_RS29545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS29570	COG1802	Transcriptional regulator
CU254_RS29575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_RS29580	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS29590	COG4977	sequence-specific DNA binding
CU254_RS29680	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS29700	COG0402	S-adenosylhomocysteine deaminase activity
CU254_RS29705	COG0667	Aldo Keto reductase
CU254_RS29720	COG1595	DNA-templated transcription, initiation
CU254_RS29730	COG0640	Transcriptional regulator
CU254_RS29755	COG1522	sequence-specific DNA binding
CU254_RS29780	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS29785	COG3284	Transcriptional regulator
CU254_RS29800	COG1846	Transcriptional regulator
CU254_RS29805	COG0488	(ABC) transporter
CU254_RS29810	COG0488	(ABC) transporter
CU254_RS29815	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS29825	COG4260	virion core protein, lumpy skin disease virus
CU254_RS29835	COG2264	protein methyltransferase activity
CU254_RS29850	COG3629	intracellular signal transduction
CU254_RS29850	COG3903	Transcriptional regulator
CU254_RS29860	COG3629	intracellular signal transduction
CU254_RS29860	COG3903	Transcriptional regulator
CU254_RS29870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CU254_RS29890	COG1215	transferase activity, transferring glycosyl groups
CU254_RS29900	COG0137	argininosuccinate synthase activity
CU254_RS29920	COG2267	carboxylic ester hydrolase activity
CU254_RS29925	COG1309	transcriptional regulator
CU254_RS29930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CU254_RS29935	COG2188	Transcriptional regulator
CU254_RS29980	COG4941	Belongs to the sigma-70 factor family
CU254_RS30000	COG1234	tRNA 3'-trailer cleavage
CU254_RS30005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU254_RS30020	COG1309	transcriptional regulator
CU254_RS30045	COG3321	synthase
CU254_RS30045	COG0604	alcohol dehydrogenase
CU254_RS30055	COG0604	alcohol dehydrogenase
CU254_RS30055	COG3321	synthase
CU254_RS30070	COG1136	(ABC) transporter
CU254_RS30070	COG0577	efflux transmembrane transporter activity
CU254_RS30090	COG3321	synthase
CU254_RS30090	COG0604	alcohol dehydrogenase
CU254_RS30090	COG3321	synthase
CU254_RS30090	COG0604	alcohol dehydrogenase
CU254_RS30095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_RS30145	COG3321	synthase
CU254_RS30145	COG0604	alcohol dehydrogenase
CU254_RS30175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_RS30190	COG2267	carboxylic ester hydrolase activity
CU254_RS30205	COG2197	response regulator
CU254_RS30215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU254_RS30240	COG1522	sequence-specific DNA binding
CU254_RS30275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_RS30280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS30300	COG2226	methyltransferase
CU254_RS30305	COG2226	methyltransferase
CU254_RS30310	COG1070	Carbohydrate kinase
CU254_RS30325	COG1595	DNA-templated transcription, initiation
CU254_RS30365	COG0242	peptide deformylase activity
CU254_RS30375	COG1024	Enoyl-CoA hydratase
CU254_RS30455	COG2226	methyltransferase
CU254_RS30470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU254_RS30485	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_RS30515	COG0747	negative chemotaxis
CU254_RS30520	COG0601	transmembrane transport
CU254_RS30525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_RS30530	COG4172	Belongs to the ABC transporter superfamily
CU254_RS30550	COG3511	phospholipase C
CU254_RS30555	COG2837	iron assimilation
CU254_RS30560	COG2822	iron ion transport
CU254_RS30570	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS30580	COG1929	Belongs to the glycerate kinase type-1 family
CU254_RS30590	COG2252	PERMEase
CU254_RS30595	COG0590	tRNA wobble adenosine to inosine editing
CU254_RS30605	COG3835	regulator
CU254_RS30625	COG1228	amidohydrolase
CU254_RS30645	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS30655	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CU254_RS30665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS30700	COG1280	lysine exporter protein (LysE YggA)
CU254_RS30715	COG1408	metallophosphoesterase
CU254_RS30725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_RS30750	COG2018	Roadblock/LC7 domain
CU254_RS30755	COG0642	Histidine kinase
CU254_RS30765	COG3844	kynureninase activity
CU254_RS30775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU254_RS30800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU254_RS30805	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS30825	COG1316	TRANSCRIPTIONal
CU254_RS30870	COG0789	Transcriptional regulator
CU254_RS30895	COG1309	transcriptional regulator
CU254_RS30905	COG0583	DNA-binding transcription factor activity
CU254_RS30935	COG5002	protein histidine kinase activity
CU254_RS30940	COG0745	RESPONSE REGULATOR receiver
CU254_RS30945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CU254_RS30950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CU254_RS30960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CU254_RS31015	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CU254_RS31020	COG1335	isochorismatase
CU254_RS31030	COG1268	BioY protein
CU254_RS31060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU254_RS31070	COG2267	carboxylic ester hydrolase activity
CU254_RS31080	COG0477	Major facilitator Superfamily
CU254_RS31105	COG0626	cystathionine gamma-synthase activity
CU254_RS31115	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS31120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU254_RS31130	COG2376	Dihydroxyacetone kinase
CU254_RS31160	COG0655	NAD(P)H dehydrogenase (quinone) activity
CU254_RS31165	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
CU254_RS31175	COG1024	Enoyl-CoA hydratase
CU254_RS31180	COG4977	sequence-specific DNA binding
CU254_RS31190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CU254_RS31190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CU254_RS31210	COG1280	lysine exporter protein (LysE YggA)
CU254_RS31220	COG0702	epimerase
CU254_RS31225	COG3631	Ketosteroid isomerase-related protein
CU254_RS31255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CU254_RS31260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CU254_RS31265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CU254_RS31270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CU254_RS31280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CU254_RS31285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CU254_RS31290	COG0356	it plays a direct role in the translocation of protons across the membrane
CU254_RS31300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CU254_RS31325	COG2890	protein-(glutamine-N5) methyltransferase activity
CU254_RS31330	COG0789	Transcriptional regulator
CU254_RS31335	COG0596	Alpha beta hydrolase
CU254_RS31340	COG3547	Transposase (IS116 IS110 IS902 family)
CU254_RS31345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS31355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CU254_RS31360	COG0254	rRNA binding
CU254_RS31375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CU254_RS31380	COG0083	homoserine kinase activity
CU254_RS31385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CU254_RS31390	COG0460	homoserine dehydrogenase
CU254_RS31395	COG0019	diaminopimelate decarboxylase activity
CU254_RS31400	COG0018	arginyl-trna synthetase
CU254_RS31420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU254_RS31430	COG0596	Alpha beta hydrolase
CU254_RS31445	COG2814	Major facilitator Superfamily
CU254_RS31450	COG1953	Uracil, thiamine, allantoin
CU254_RS31485	COG3629	intracellular signal transduction
CU254_RS31485	COG3903	Transcriptional regulator
CU254_RS31495	COG0402	S-adenosylhomocysteine deaminase activity
CU254_RS31505	COG0477	Major facilitator Superfamily
CU254_RS31510	COG0277	FAD linked oxidase domain protein
CU254_RS31530	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CU254_RS31550	COG3226	Transcriptional regulator
CU254_RS31570	COG0583	DNA-binding transcription factor activity
CU254_RS31580	COG2132	Multicopper oxidase
CU254_RS31585	COG2197	response regulator
CU254_RS31595	COG1309	transcriptional regulator
CU254_RS31630	COG1595	DNA-templated transcription, initiation
CU254_RS31635	COG1252	NADH dehydrogenase
CU254_RS31640	COG0454	-acetyltransferase
CU254_RS31645	COG0488	(ABC) transporter
CU254_RS31655	COG2226	methyltransferase
CU254_RS31680	COG0159	tryptophan synthase activity
CU254_RS31685	COG2188	Transcriptional regulator
CU254_RS31700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU254_RS31710	COG2197	response regulator
CU254_RS31715	COG4585	Histidine kinase
CU254_RS31760	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS31765	COG3835	regulator
CU254_RS31775	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS31780	COG0583	DNA-binding transcription factor activity
CU254_RS31810	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS31910	COG0477	Major facilitator Superfamily
CU254_RS31915	COG1802	Transcriptional regulator
CU254_RS31945	COG0667	Aldo Keto reductase
CU254_RS31960	COG0154	amidase activity
CU254_RS31980	COG2186	Transcriptional regulator
CU254_RS31995	COG0473	3-isopropylmalate dehydrogenase activity
CU254_RS32005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CU254_RS32020	COG0028	Belongs to the TPP enzyme family
CU254_RS32050	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS32050	COG1024	Enoyl-CoA hydratase
CU254_RS32055	COG0183	Belongs to the thiolase family
CU254_RS32060	COG1309	transcriptional regulator
CU254_RS32075	COG1960	acyl-CoA dehydrogenase activity
CU254_RS32105	COG1733	regulation of RNA biosynthetic process
CU254_RS32110	COG0604	alcohol dehydrogenase
CU254_RS32110	COG3321	synthase
CU254_RS32110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_RS32110	COG4221	oxidoreductase activity
CU254_RS32120	COG3243	poly(R)-hydroxyalkanoic acid synthase
CU254_RS32125	COG4221	oxidoreductase activity
CU254_RS32135	COG1960	acyl-CoA dehydrogenase activity
CU254_RS32145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU254_RS32165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU254_RS32195	COG0686	Belongs to the AlaDH PNT family
CU254_RS32200	COG1132	(ABC) transporter
CU254_RS32230	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU254_RS32230	COG0567	Dehydrogenase, E1 component
CU254_RS32265	COG1174	glycine betaine transport
CU254_RS32270	COG1174	glycine betaine transport
CU254_RS32275	COG1125	glycine betaine transport
CU254_RS32275	COG0517	IMP dehydrogenase activity
CU254_RS32290	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CU254_RS32305	COG0406	alpha-ribazole phosphatase activity
CU254_RS32325	COG1597	lipid kinase activity
CU254_RS32345	COG1595	DNA-templated transcription, initiation
CU254_RS32350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CU254_RS32355	COG2226	methyltransferase
CU254_RS32365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS32385	COG2135	peptidase activity
CU254_RS32390	COG1162	GTPase activity
CU254_RS32420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_RS32425	COG1011	Hydrolase
CU254_RS32435	COG0653	protein targeting
CU254_RS32440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CU254_RS32450	COG5401	PFAM Sporulation and spore germination
CU254_RS32455	COG5002	protein histidine kinase activity
CU254_RS32460	COG0745	RESPONSE REGULATOR receiver
CU254_RS32485	COG1309	transcriptional regulator
CU254_RS32505	COG0442	prolyl-tRNA aminoacylation
CU254_RS32525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CU254_RS32540	COG0531	amino acid
CU254_RS32550	COG3620	sequence-specific DNA binding
CU254_RS32560	COG1482	cell wall glycoprotein biosynthetic process
CU254_RS32570	COG2835	tetraacyldisaccharide 4'-kinase activity
CU254_RS32605	COG1994	Peptidase M50
CU254_RS32620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_RS32625	COG0747	negative chemotaxis
CU254_RS32630	COG0601	transmembrane transport
CU254_RS32645	COG4608	Belongs to the ABC transporter superfamily
CU254_RS32650	COG0747	negative chemotaxis
CU254_RS32655	COG1217	gtp-binding protein TYPA
CU254_RS32670	COG0180	Tryptophanyl-tRNA synthetase
CU254_RS32675	COG0494	nUDIX hydrolase
CU254_RS32675	COG0406	alpha-ribazole phosphatase activity
CU254_RS32680	COG2205	protein histidine kinase activity
CU254_RS32685	COG0745	RESPONSE REGULATOR receiver
CU254_RS32695	COG1131	(ABC) transporter
CU254_RS32705	COG3842	ATPase activity
CU254_RS32720	COG2154	pterin-4-alpha-carbinolamine dehydratase
CU254_RS32740	COG0012	GTP binding
CU254_RS32755	COG0419	ATPase involved in DNA repair
CU254_RS32760	COG0420	3'-5' exonuclease activity
CU254_RS32775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CU254_RS32785	COG1570	exodeoxyribonuclease VII activity
CU254_RS32795	COG1722	exodeoxyribonuclease VII activity
CU254_RS32810	COG0492	ferredoxin-NADP+ reductase activity
CU254_RS32815	COG0114	fumarate hydratase activity
CU254_RS32825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU254_RS32870	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CU254_RS32900	COG1331	Highly conserved protein containing a thioredoxin domain
CU254_RS32930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_RS32940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CU254_RS32945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS32950	COG1522	sequence-specific DNA binding
CU254_RS32955	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CU254_RS32985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CU254_RS33025	COG0183	Belongs to the thiolase family
CU254_RS33030	COG0477	Major facilitator Superfamily
CU254_RS33110	COG1175	transmembrane transport
CU254_RS33120	COG2197	response regulator
CU254_RS33125	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_RS33145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU254_RS33150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CU254_RS33185	COG1175	transmembrane transport
CU254_RS33190	COG0395	ABC-type sugar transport system, permease component
CU254_RS33225	COG1876	peptidase activity
CU254_RS33250	COG0671	phosphoesterase, PA-phosphatase related
CU254_RS33270	COG0726	polysaccharide deacetylase
CU254_RS33280	COG1316	TRANSCRIPTIONal
CU254_RS33305	COG1414	Transcriptional regulator
CU254_RS33310	COG3591	Belongs to the peptidase S1B family
CU254_RS33315	COG0154	amidase activity
CU254_RS33385	COG2508	Transcriptional regulator
CU254_RS33385	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CU254_RS33390	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_RS33405	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CU254_RS33420	COG2271	Major facilitator Superfamily
CU254_RS33445	COG3239	Fatty acid desaturase
CU254_RS33460	COG2814	Major facilitator Superfamily
CU254_RS33470	COG1252	NADH dehydrogenase
CU254_RS33485	COG2197	response regulator
CU254_RS33495	COG1131	(ABC) transporter
CU254_RS33520	COG4608	Belongs to the ABC transporter superfamily
CU254_RS33525	COG0444	Belongs to the ABC transporter superfamily
CU254_RS33535	COG0601	transmembrane transport
CU254_RS33555	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS33560	COG0583	DNA-binding transcription factor activity
CU254_RS33585	COG0148	phosphopyruvate hydratase activity
CU254_RS33610	COG0672	)-iron permease
CU254_RS33620	COG2837	iron assimilation
CU254_RS33625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS33645	COG1131	(ABC) transporter
CU254_RS33660	COG3956	TIGRFAM MazG family protein
CU254_RS33680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS33690	COG0586	Pfam SNARE associated Golgi protein
CU254_RS33700	COG4585	Histidine kinase
CU254_RS33705	COG2197	response regulator
CU254_RS33710	COG2133	pyrroloquinoline quinone binding
CU254_RS33715	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS33755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CU254_RS33775	COG1309	transcriptional regulator
CU254_RS33800	COG0193	aminoacyl-tRNA hydrolase activity
CU254_RS33810	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS33815	COG0488	(ABC) transporter
CU254_RS33820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CU254_RS33830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CU254_RS33835	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CU254_RS33840	COG3583	domain protein
CU254_RS33845	COG0084	hydrolase, TatD family'
CU254_RS33850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU254_RS33910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CU254_RS33915	COG0515	serine threonine protein kinase
CU254_RS33935	COG2258	MOSC domain
CU254_RS33945	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS34005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU254_RS34010	COG2197	response regulator
CU254_RS34045	COG1902	pentaerythritol trinitrate reductase activity
CU254_RS34050	COG2267	carboxylic ester hydrolase activity
CU254_RS34055	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS34065	COG0583	DNA-binding transcription factor activity
CU254_RS34080	COG0583	DNA-binding transcription factor activity
CU254_RS34090	COG3209	COG3209 Rhs family protein
CU254_RS34130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU254_RS34140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CU254_RS34145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CU254_RS34170	COG0315	cyclic pyranopterin monophosphate synthase activity
CU254_RS34170	COG0521	Mo-molybdopterin cofactor biosynthetic process
CU254_RS34185	COG5002	protein histidine kinase activity
CU254_RS34190	COG0745	RESPONSE REGULATOR receiver
CU254_RS34225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU254_RS34235	COG1349	DNA-binding transcription factor activity
CU254_RS34250	COG2860	membrane
CU254_RS34255	COG2197	response regulator
CU254_RS34290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU254_RS34330	COG0477	Major facilitator Superfamily
CU254_RS34335	COG0702	epimerase
CU254_RS34440	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS34450	COG1960	acyl-CoA dehydrogenase activity
CU254_RS34460	COG0583	DNA-binding transcription factor activity
CU254_RS34485	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU254_RS34505	COG0275	rRNA processing
CU254_RS34535	COG3285	dna ligase
CU254_RS34535	COG1793	dna ligase
CU254_RS34550	COG0583	DNA-binding transcription factor activity
CU254_RS34590	COG1960	acyl-CoA dehydrogenase activity
CU254_RS34610	COG2814	Major facilitator Superfamily
CU254_RS34615	COG4336	lyase activity
CU254_RS34620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CU254_RS34630	COG1984	allophanate hydrolase subunit 2
CU254_RS34655	COG1321	iron dependent repressor
CU254_RS34670	COG1024	Enoyl-CoA hydratase
CU254_RS34675	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS34695	COG1169	isochorismate synthase
CU254_RS34710	COG2182	Extracellular solute-binding protein
CU254_RS34715	COG1175	transmembrane transport
CU254_RS34720	COG0395	ABC-type sugar transport system, permease component
CU254_RS34760	COG2226	methyltransferase
CU254_RS34765	COG0277	FAD linked oxidase domain protein
CU254_RS34790	COG4152	abc transporter atp-binding protein
CU254_RS34795	COG1668	transmembrane transport
CU254_RS34800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CU254_RS34810	COG0415	Belongs to the DNA photolyase family
CU254_RS34820	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CU254_RS34820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CU254_RS34830	COG1960	acyl-CoA dehydrogenase activity
CU254_RS34835	COG1733	regulation of RNA biosynthetic process
CU254_RS34850	COG1228	amidohydrolase
CU254_RS34865	COG1309	transcriptional regulator
CU254_RS34880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CU254_RS34885	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS34895	COG1113	amino acid transport
CU254_RS34900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU254_RS34905	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CU254_RS34910	COG0028	Belongs to the TPP enzyme family
CU254_RS34935	COG0259	pyridoxamine-phosphate oxidase activity
CU254_RS34945	COG0829	nickel cation binding
CU254_RS34950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CU254_RS34960	COG0804	urea catabolic process
CU254_RS34965	COG0832	Belongs to the urease beta subunit family
CU254_RS34970	COG0831	urea catabolic process
CU254_RS35000	COG4585	Histidine kinase
CU254_RS35010	COG1609	Transcriptional regulator
CU254_RS35015	COG1397	ADP-ribosylglycohydrolase
CU254_RS35055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_RS35070	COG5398	heme oxygenase
CU254_RS35085	COG2814	Major facilitator Superfamily
CU254_RS35095	COG2252	PERMEase
CU254_RS35120	COG2814	Major facilitator Superfamily
CU254_RS35130	COG1278	Cold shock
CU254_RS35145	COG1309	transcriptional regulator
CU254_RS35150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU254_RS35155	COG0318	PFAM AMP-dependent synthetase and ligase
CU254_RS35170	COG3304	Inner membrane component domain
CU254_RS35185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CU254_RS35220	COG1846	Transcriptional regulator
CU254_RS35270	COG2018	Roadblock/LC7 domain
CU254_RS35285	COG2018	Roadblock/LC7 domain
CU254_RS35295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU254_RS35305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU254_RS35310	COG1116	anion transmembrane transporter activity
CU254_RS35310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU254_RS35330	COG3142	Participates in the control of copper homeostasis
CU254_RS35350	COG1061	Type III restriction enzyme res subunit
CU254_RS35370	COG2319	Wd-40 repeat
CU254_RS35370	COG3903	Transcriptional regulator
CU254_RS35375	COG4948	Mandelate Racemase Muconate Lactonizing
CU254_RS35385	COG0459	protein refolding
CU254_RS35395	COG1278	Cold shock
CU254_RS35420	COG2261	transglycosylase associated protein
CU254_RS35430	COG0688	phosphatidylethanolamine metabolic process
CU254_RS35445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU254_RS35460	COG0242	peptide deformylase activity
CU254_RS35465	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CU254_RS35470	COG0351	phosphomethylpyrimidine kinase
CU254_RS35505	COG2022	thiamine diphosphate biosynthetic process
CU254_RS35515	COG2022	thiamine diphosphate biosynthetic process
CU254_RS35515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU254_RS35520	COG0352	thiamine-phosphate diphosphorylase activity
CU254_RS35530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CU254_RS35550	COG0477	Major facilitator Superfamily
CU254_RS35555	COG2188	Transcriptional regulator
CU254_RS35560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CU254_RS35575	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CU254_RS35605	COG3903	Transcriptional regulator
CU254_RS35605	COG3629	intracellular signal transduction
CU254_RS35610	COG5285	phytanoyl-CoA dioxygenase
CU254_RS35615	COG1917	Cupin 2, conserved barrel domain protein
CU254_RS35625	COG0456	acetyltransferase
CU254_RS35630	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU254_RS35635	COG4399	Belongs to the UPF0754 family
CU254_RS35650	COG5416	Lipopolysaccharide assembly protein A domain
CU254_RS35720	COG3971	2-oxopent-4-enoate hydratase activity
CU254_RS35725	COG0346	lactoylglutathione lyase activity
CU254_RS35735	COG1832	CoA-binding protein
CU254_RS35745	COG0745	RESPONSE REGULATOR receiver
CU254_RS35750	COG2205	protein histidine kinase activity
CU254_RS35755	COG1492	cobalamin metabolic process
CU254_RS35760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CU254_RS35765	COG1414	Transcriptional regulator
CU254_RS35770	COG4941	Belongs to the sigma-70 factor family
CU254_RS35780	COG3795	YCII-related domain
CU254_RS35795	COG2124	cytochrome p450
CU254_RS35800	COG0596	Alpha beta hydrolase
CU254_RS35805	COG1946	Acyl-CoA thioesterase
CU254_RS35830	COG4566	intracellular signal transduction
CU254_RS35850	COG3852	Histidine kinase
CU254_RS35865	COG4638	Rieske (2fe-2S)
CU254_RS35885	COG0477	Major facilitator Superfamily
CU254_RS35960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CU254_RS35970	COG1329	Transcriptional regulator
CU254_RS35975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CU254_RS35980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CU254_RS36000	COG0215	cysteine-tRNA ligase activity
CU254_RS36005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_RS36025	COG0235	Class ii aldolase
CU254_RS36035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CU254_RS36040	COG0698	ribose 5-phosphate isomerase
CU254_RS36045	COG2376	Dihydroxyacetone kinase
CU254_RS36050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_RS36055	COG0406	alpha-ribazole phosphatase activity
CU254_RS36060	COG1349	DNA-binding transcription factor activity
CU254_RS36065	COG2814	Major facilitator Superfamily
CU254_RS36070	COG1070	Carbohydrate kinase
CU254_RS36090	COG4399	Belongs to the UPF0754 family
CU254_RS36110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU254_RS36115	COG1120	ATPase activity
CU254_RS36120	COG0803	Belongs to the bacterial solute-binding protein 9 family
CU254_RS36125	COG1609	Transcriptional regulator
CU254_RS36135	COG1194	a g-specific adenine glycosylase
CU254_RS36205	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CU254_RS36210	COG0443	Heat shock 70 kDa protein
CU254_RS36245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CU254_RS36255	COG2076	Multidrug Resistance protein
CU254_RS36260	COG1595	DNA-templated transcription, initiation
CU254_RS36270	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CU254_RS36275	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CU254_RS36280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CU254_RS36305	COG0789	Transcriptional regulator
CU254_RS36330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU254_RS36370	COG2027	D-alanyl-D-alanine carboxypeptidase
CU254_RS36375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CU254_RS36385	COG3795	YCII-related domain
CU254_RS36390	COG4941	Belongs to the sigma-70 factor family
CU254_RS36395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CU254_RS36420	COG0640	Transcriptional regulator
CU254_RS36450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CU254_RS36455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CU254_RS36470	COG2223	nitrite transmembrane transporter activity
CU254_RS36475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU254_RS36475	COG1754	DNA topoisomerase type I activity
CU254_RS36500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CU254_RS36505	COG1111	helicase
CU254_RS36505	COG1205	dead DEAH box helicase
CU254_RS36555	COG1472	Belongs to the glycosyl hydrolase 3 family
CU254_RS36560	COG3876	Protein conserved in bacteria
CU254_RS36565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU254_RS36570	COG1737	Transcriptional regulator
CU254_RS36575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CU254_RS36580	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CU254_RS36585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_RS36590	COG1595	DNA-templated transcription, initiation
CU254_RS36595	COG0667	Aldo Keto reductase
CU254_RS36615	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS36625	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CU254_RS36635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU254_RS36690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU254_RS36710	COG1902	pentaerythritol trinitrate reductase activity
CU254_RS36720	COG3104	oligopeptide transport
CU254_RS36725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CU254_RS36735	COG0596	Alpha beta hydrolase
CU254_RS36790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS36840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_RS36845	COG1408	metallophosphoesterase
CU254_RS36870	COG0076	glutamate decarboxylase activity
CU254_RS36875	COG0783	Belongs to the Dps family
CU254_RS36880	COG1764	response to oxidative stress
CU254_RS36885	COG0431	NADPH-dependent FMN reductase
CU254_RS36890	COG0657	acetylesterase activity
CU254_RS36910	COG1690	Belongs to the RtcB family
CU254_RS36960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU254_RS36970	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS36980	COG0583	DNA-binding transcription factor activity
CU254_RS36985	COG0697	spore germination
CU254_RS36995	COG0586	Pfam SNARE associated Golgi protein
CU254_RS37000	COG4941	Belongs to the sigma-70 factor family
CU254_RS37015	COG4608	Belongs to the ABC transporter superfamily
CU254_RS37020	COG0444	Belongs to the ABC transporter superfamily
CU254_RS37025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_RS37030	COG0601	transmembrane transport
CU254_RS37035	COG0747	negative chemotaxis
CU254_RS37055	COG0463	Glycosyl transferase, family 2
CU254_RS37070	COG1215	transferase activity, transferring glycosyl groups
CU254_RS37075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CU254_RS37085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CU254_RS37090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CU254_RS37095	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU254_RS37135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CU254_RS37140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_RS37145	COG2205	protein histidine kinase activity
CU254_RS37150	COG0745	RESPONSE REGULATOR receiver
CU254_RS37175	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU254_RS37210	COG2813	Specifically methylates the guanine in position
CU254_RS37225	COG0477	Major facilitator Superfamily
CU254_RS37250	COG1674	ftsk spoiiie
CU254_RS37265	COG2843	Capsule synthesis protein
CU254_RS37270	COG2267	carboxylic ester hydrolase activity
CU254_RS37280	COG2175	clavaminate synthase activity
CU254_RS37295	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_RS37315	COG1473	amidohydrolase
CU254_RS37325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU254_RS37395	COG0596	Alpha beta hydrolase
CU254_RS37400	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CU254_RS37430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CU254_RS37455	COG0745	RESPONSE REGULATOR receiver
CU254_RS37490	COG4044	May play a role in the intracellular transport of hydrophobic ligands
CU254_RS37500	COG1984	allophanate hydrolase subunit 2
CU254_RS37520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CU254_RS37560	COG3845	ABC transporter
CU254_RS37645	COG0778	Nitroreductase
CU254_RS37655	COG1132	(ABC) transporter
CU254_RS37660	COG1132	(ABC) transporter
CU254_RS37675	COG0047	phosphoribosylformylglycinamidine synthase activity
CU254_RS37680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CU254_RS37730	COG2226	methyltransferase
CU254_RS37750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CU254_RS37775	COG0765	amino acid transport
CU254_RS37790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CU254_RS37805	COG0800	Aldolase
CU254_RS37855	COG1011	Hydrolase
CU254_RS37865	COG0436	Aminotransferase
CU254_RS37870	COG3953	SLT domain
CU254_RS37870	COG5280	Phage tail tape measure protein TP901
CU254_RS37905	COG0584	glycerophosphoryl diester phosphodiesterase
CU254_RS37925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS37940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CU254_RS37975	COG2153	protein acetylation
CU254_RS38000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU254_RS38015	COG0667	Aldo Keto reductase
CU254_RS38020	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS38075	COG0586	Pfam SNARE associated Golgi protein
CU254_RS38080	COG0277	FAD linked oxidase domain protein
CU254_RS38085	COG0500	methyltransferase
CU254_RS38095	COG1309	transcriptional regulator
CU254_RS38100	COG0477	Major facilitator Superfamily
CU254_RS38110	COG3467	pyridoxamine 5'-phosphate
CU254_RS38130	COG0586	Pfam SNARE associated Golgi protein
CU254_RS38150	COG0572	uridine kinase
CU254_RS38155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_RS38175	COG1609	Transcriptional regulator
CU254_RS38190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU254_RS38230	COG1136	(ABC) transporter
CU254_RS38230	COG0577	efflux transmembrane transporter activity
CU254_RS38235	COG0300	oxidoreductase activity
CU254_RS38250	COG2826	transposase and inactivated derivatives, IS30 family
CU254_RS38265	COG0542	response to heat
CU254_RS38300	COG0789	Transcriptional regulator
CU254_RS38305	COG0484	heat shock protein binding
CU254_RS38310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CU254_RS38315	COG0443	Heat shock 70 kDa protein
CU254_RS38355	COG2181	nitrate reductase activity
CU254_RS38355	COG0247	lactate metabolic process
CU254_RS38365	COG2340	Cysteine-rich secretory protein family
CU254_RS38370	COG3848	Pyruvate phosphate dikinase
CU254_RS38370	COG0574	Belongs to the PEP-utilizing enzyme family
CU254_RS38380	COG1846	Transcriptional regulator
CU254_RS38390	COG0717	Belongs to the dCTP deaminase family
CU254_RS38440	COG1960	acyl-CoA dehydrogenase activity
CU254_RS38445	COG2197	response regulator
CU254_RS38455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU254_RS38465	COG1525	nuclease
CU254_RS38465	COG0737	Belongs to the 5'-nucleotidase family
CU254_RS38465	COG4085	toxin activity
CU254_RS38475	COG2720	vancomycin resistance protein
CU254_RS38480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CU254_RS38530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU254_RS38545	COG1305	Transglutaminase-like
CU254_RS38550	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_RS38555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU254_RS38565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU254_RS38575	COG0022	dehydrogenase e1 component
CU254_RS38580	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU254_RS38595	COG4133	protoheme IX ABC transporter activity
CU254_RS38605	COG3030	protein affecting phage T7 exclusion by the F plasmid
CU254_RS38630	COG1309	transcriptional regulator
CU254_RS38635	COG2030	dehydratase
CU254_RS38640	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS38645	COG0183	Belongs to the thiolase family
CU254_RS38665	COG0456	acetyltransferase
CU254_RS38685	COG2826	transposase and inactivated derivatives, IS30 family
CU254_RS38720	COG1131	(ABC) transporter
CU254_RS38730	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CU254_RS38750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CU254_RS38775	COG4585	Histidine kinase
CU254_RS38780	COG2197	response regulator
CU254_RS38795	COG1131	(ABC) transporter
CU254_RS38810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CU254_RS38820	COG1136	(ABC) transporter
CU254_RS38830	COG2197	response regulator
CU254_RS38835	COG0402	S-adenosylhomocysteine deaminase activity
CU254_RS38840	COG4221	oxidoreductase activity
CU254_RS38845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CU254_RS38860	COG2814	Major facilitator Superfamily
CU254_RS38870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU254_RS38880	COG1695	Transcriptional regulator
CU254_RS38890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_RS38895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU254_RS38900	COG0673	inositol 2-dehydrogenase activity
CU254_RS38905	COG1940	carbohydrate kinase activity
CU254_RS38940	COG0360	Binds together with S18 to 16S ribosomal RNA
CU254_RS38950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CU254_RS38955	COG0359	binds to the 23S rRNA
CU254_RS38985	COG0640	Transcriptional regulator
CU254_RS39000	COG3384	dioxygenase
CU254_RS39025	COG2197	response regulator
CU254_RS39040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CU254_RS39045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU254_RS39055	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS39075	COG0495	leucyl-tRNA aminoacylation
CU254_RS39090	COG1678	Uncharacterized ACR, COG1678
CU254_RS39125	COG4585	Histidine kinase
CU254_RS39130	COG0617	tRNA 3'-terminal CCA addition
CU254_RS39155	COG1595	DNA-templated transcription, initiation
CU254_RS39170	COG0492	ferredoxin-NADP+ reductase activity
CU254_RS39170	COG3118	belongs to the thioredoxin family
CU254_RS39175	COG3409	Peptidoglycan-binding domain 1 protein
CU254_RS39175	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU254_RS39190	COG1181	Belongs to the D-alanine--D-alanine ligase family
CU254_RS39200	COG1192	Involved in chromosome partitioning
CU254_RS39205	COG0357	Ribosomal RNA small subunit methyltransferase G
CU254_RS39215	COG0706	membrane insertase activity
CU254_RS39220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CU254_RS39225	COG0594	ribonuclease P activity
CU254_RS39240	COG0592	DNA-directed DNA polymerase activity
CU254_RS39245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CU254_RS39250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CU254_RS39255	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
CU254_RS39260	COG0187	DNA topoisomerase II activity
CU254_RS39265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU254_RS39285	COG3173	Aminoglycoside phosphotransferase
CU254_RS39330	COG3973	AAA domain
CU254_RS39335	COG5650	phosphatidylinositol metabolic process
CU254_RS39355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU254_RS39400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CU254_RS39420	COG3764	Sortase (surface protein transpeptidase)
CU254_RS39440	COG1131	(ABC) transporter
CU254_RS39450	COG2197	response regulator
CU254_RS39460	COG0604	alcohol dehydrogenase
CU254_RS39490	COG0515	serine threonine protein kinase
CU254_RS39490	COG2815	serine threonine protein kinase
CU254_RS39495	COG0515	serine threonine protein kinase
CU254_RS39500	COG0768	penicillin binding
CU254_RS39515	COG1716	ATPase activity
CU254_RS39520	COG1716	ATPase activity
CU254_RS39600	COG2186	Transcriptional regulator
CU254_RS39605	COG0747	negative chemotaxis
CU254_RS39615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU254_RS39620	COG0444	Belongs to the ABC transporter superfamily
CU254_RS39630	COG1012	belongs to the aldehyde dehydrogenase family
CU254_RS39640	COG0154	amidase activity
CU254_RS39660	COG2301	Belongs to the HpcH HpaI aldolase family
CU254_RS39670	COG0702	epimerase
CU254_RS39675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CU254_RS39700	COG2211	Major facilitator Superfamily
CU254_RS39705	COG0789	Transcriptional regulator
CU254_RS39710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU254_RS39715	COG3209	COG3209 Rhs family protein
CU254_RS39745	COG1276	copper resistance
CU254_RS39745	COG2372	response to copper ion
CU254_RS39760	COG1174	glycine betaine transport
CU254_RS39770	COG1174	glycine betaine transport
CU254_RS39795	COG2226	methyltransferase
CU254_RS39805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU254_RS39830	COG0477	Major facilitator Superfamily
CU254_RS39840	COG4585	Histidine kinase
CU254_RS39845	COG2197	response regulator
CU254_RS39910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CU254_RS39920	COG3275	phosphorelay sensor kinase activity
CU254_RS39930	COG3279	Response regulator of the LytR AlgR family
CU254_RS39940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU254_RS39960	COG2814	Major facilitator Superfamily
CU254_RS39965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU254_RS39985	COG1191	sigma factor activity
CU254_RS40050	COG1271	oxidase subunit
CU254_RS40055	COG1294	oxidase, subunit
CU254_RS40060	COG4988	ABC transporter
CU254_RS40070	COG0596	Alpha beta hydrolase
CU254_RS40115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CU254_RS40125	COG0588	phosphoglycerate mutase activity
CU254_RS40160	COG0754	glutathionylspermidine amidase activity
CU254_RS40170	COG0596	Alpha beta hydrolase
CU254_RS40180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU254_RS40185	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CU254_RS40200	COG0579	oxidoreductase
CU254_RS40210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CU254_RS40225	COG0110	maltose O-acetyltransferase activity
CU254_RS40250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CU254_RS40255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CU254_RS40265	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS40305	COG0561	phosphatase activity
CU254_RS40310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU254_RS40325	COG0671	phosphoesterase, PA-phosphatase related
CU254_RS40330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CU254_RS40370	COG1028	Short-chain dehydrogenase reductase Sdr
CU254_RS40375	COG0277	FAD linked oxidase domain protein
CU254_RS40385	COG1216	Glycosyl transferase, family 2
CU254_RS40400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CU254_RS40425	COG1216	Glycosyl transferase, family 2
CU254_RS40445	COG0596	Alpha beta hydrolase
CU254_RS40460	COG1063	alcohol dehydrogenase
CU254_RS40480	COG4249	Peptidase C14 caspase catalytic subunit p20
CU254_RS40515	COG4565	transcriptional regulatory protein
CU254_RS40520	COG3290	protein histidine kinase activity
CU254_RS40525	COG1116	anion transmembrane transporter activity
CU254_RS40545	COG2329	Antibiotic biosynthesis monooxygenase
CU254_RS40570	COG1522	sequence-specific DNA binding
CU254_RS40575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU254_RS40595	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU254_RS40605	COG2186	Transcriptional regulator
CU254_RS40625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU254_RS40635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU254_RS40640	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CU254_RS40640	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CU254_RS40675	COG2274	protein secretion by the type I secretion system
CU254_RS40680	COG1132	(ABC) transporter
CU254_RS40695	COG2197	response regulator
CU254_RS40705	COG0842	Transport permease protein
CU254_RS40725	COG2326	polyphosphate kinase activity
CU254_RS40755	COG1404	Belongs to the peptidase S8 family
CU254_RS40775	COG2172	sigma factor antagonist activity
CU254_RS40785	COG1366	Belongs to the anti-sigma-factor antagonist family
CU254_RS40800	COG0702	epimerase
CU254_RS40840	COG3559	Exporter of polyketide antibiotics
CU254_RS40845	COG1131	(ABC) transporter
CU254_RS40975	COG2175	clavaminate synthase activity
CU254_RS40995	COG0602	queuosine metabolic process
CU254_RS41020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CU254_RS41050	COG0483	inositol monophosphate 1-phosphatase activity
CU254_RS41055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CU254_RS41090	COG3629	intracellular signal transduction
CU254_RS41090	COG3903	Transcriptional regulator
CU254_RS41110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU254_RS41200	COG0515	serine threonine protein kinase
CU254_RS41215	COG1994	Peptidase M50
CU254_RS41250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU254_RS41470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU254_RS41520	COG1192	Involved in chromosome partitioning
CU254_RS41605	COG5001	Diguanylate cyclase
CU254_RS41870	COG0484	heat shock protein binding
CU254_RS42040	COG2814	Major facilitator Superfamily
CU254_RS42045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU254_RS42065	COG1509	lysine 2,3-aminomutase activity
CU254_RS42075	COG1335	isochorismatase
CU254_RS42085	COG2301	Belongs to the HpcH HpaI aldolase family
CU254_RS42090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CU254_RS42095	COG2030	dehydratase
CU254_RS42100	COG2188	Transcriptional regulator
CU254_RS42105	COG2271	Major facilitator Superfamily
CU254_RS42125	COG3033	Beta-eliminating lyase
CU254_RS42200	COG0587	DNA-directed DNA polymerase activity
CU254_RS42340	COG2267	carboxylic ester hydrolase activity
CU254_RS42345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU254_RS42665	COG0358	DNA primase activity