locus-tag	class	description
I6J71_RS00015	COG1408	metallophosphoesterase
I6J71_RS00030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6J71_RS00080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_RS00130	COG0596	Alpha beta hydrolase
I6J71_RS00140	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J71_RS00145	COG3104	oligopeptide transport
I6J71_RS00170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_RS00180	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6J71_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS00205	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6J71_RS00210	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J71_RS00215	COG1737	Transcriptional regulator
I6J71_RS00220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J71_RS00225	COG3876	Protein conserved in bacteria
I6J71_RS00230	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_RS00290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6J71_RS00320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J71_RS00320	COG1754	DNA topoisomerase type I activity
I6J71_RS00325	COG2223	nitrite transmembrane transporter activity
I6J71_RS00340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6J71_RS00345	COG0470	DNA polymerase III
I6J71_RS00385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J71_RS00390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J71_RS00395	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J71_RS00405	COG0037	tRNA processing
I6J71_RS00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J71_RS00440	COG0302	gtp cyclohydrolase
I6J71_RS00445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J71_RS00460	COG0789	Transcriptional regulator
I6J71_RS00485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J71_RS00490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J71_RS00495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J71_RS00505	COG1595	DNA-templated transcription, initiation
I6J71_RS00515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J71_RS00550	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6J71_RS00585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J71_RS00625	COG1609	Transcriptional regulator
I6J71_RS00635	COG1121	(ABC) transporter
I6J71_RS00640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J71_RS00650	COG4399	Belongs to the UPF0754 family
I6J71_RS00670	COG0235	Class ii aldolase
I6J71_RS00685	COG0215	cysteine-tRNA ligase activity
I6J71_RS00705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6J71_RS00710	COG1329	Transcriptional regulator
I6J71_RS00715	COG2847	Copper chaperone PCu(A)C
I6J71_RS00720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J71_RS00745	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J71_RS00765	COG0784	Response regulator, receiver
I6J71_RS00765	COG2198	Histidine kinase
I6J71_RS00765	COG2205	protein histidine kinase activity
I6J71_RS00800	COG1309	transcriptional regulator
I6J71_RS00835	COG1946	Acyl-CoA thioesterase
I6J71_RS00840	COG0596	Alpha beta hydrolase
I6J71_RS00845	COG2124	cytochrome p450
I6J71_RS00880	COG3795	YCII-related domain
I6J71_RS00890	COG4941	Belongs to the sigma-70 factor family
I6J71_RS00910	COG2205	protein histidine kinase activity
I6J71_RS00915	COG0745	RESPONSE REGULATOR receiver
I6J71_RS00925	COG1832	CoA-binding protein
I6J71_RS00930	COG0346	lactoylglutathione lyase activity
I6J71_RS01005	COG0346	lactoylglutathione lyase activity
I6J71_RS01010	COG0400	carboxylic ester hydrolase activity
I6J71_RS01020	COG5416	Lipopolysaccharide assembly protein A domain
I6J71_RS01035	COG4399	Belongs to the UPF0754 family
I6J71_RS01045	COG0456	acetyltransferase
I6J71_RS01055	COG1917	Cupin 2, conserved barrel domain protein
I6J71_RS01060	COG5285	phytanoyl-CoA dioxygenase
I6J71_RS01065	COG3903	Transcriptional regulator
I6J71_RS01065	COG3629	intracellular signal transduction
I6J71_RS01095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J71_RS01100	COG2971	BadF BadG BcrA BcrD
I6J71_RS01105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J71_RS01110	COG2188	Transcriptional regulator
I6J71_RS01115	COG0477	Major facilitator Superfamily
I6J71_RS01120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J71_RS01130	COG0352	thiamine-phosphate diphosphorylase activity
I6J71_RS01135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J71_RS01135	COG2022	thiamine diphosphate biosynthetic process
I6J71_RS01145	COG2022	thiamine diphosphate biosynthetic process
I6J71_RS01165	COG0604	alcohol dehydrogenase
I6J71_RS01180	COG0351	phosphomethylpyrimidine kinase
I6J71_RS01185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6J71_RS01190	COG0242	peptide deformylase activity
I6J71_RS01205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J71_RS01215	COG0688	phosphatidylethanolamine metabolic process
I6J71_RS01225	COG2261	transglycosylase associated protein
I6J71_RS01255	COG1278	Cold shock
I6J71_RS01265	COG0459	protein refolding
I6J71_RS01275	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS01280	COG3629	intracellular signal transduction
I6J71_RS01280	COG3903	Transcriptional regulator
I6J71_RS01295	COG1061	Type III restriction enzyme res subunit
I6J71_RS01370	COG1116	anion transmembrane transporter activity
I6J71_RS01375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS01380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS01385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_RS01395	COG2018	Roadblock/LC7 domain
I6J71_RS01410	COG2018	Roadblock/LC7 domain
I6J71_RS01485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J71_RS01490	COG3304	Inner membrane component domain
I6J71_RS01495	COG0384	phenazine biosynthesis protein PhzF
I6J71_RS01520	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS01525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J71_RS01535	COG0546	phosphoglycolate phosphatase activity
I6J71_RS01545	COG1278	Cold shock
I6J71_RS01555	COG2814	Major facilitator Superfamily
I6J71_RS01580	COG2252	PERMEase
I6J71_RS01590	COG2814	Major facilitator Superfamily
I6J71_RS01595	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6J71_RS01605	COG5398	heme oxygenase
I6J71_RS01620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J71_RS01645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J71_RS01685	COG0831	urea catabolic process
I6J71_RS01690	COG0832	Belongs to the urease beta subunit family
I6J71_RS01695	COG0804	urea catabolic process
I6J71_RS01705	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6J71_RS01710	COG0829	nickel cation binding
I6J71_RS01720	COG0259	pyridoxamine-phosphate oxidase activity
I6J71_RS01745	COG1309	transcriptional regulator
I6J71_RS01750	COG2017	converts alpha-aldose to the beta-anomer
I6J71_RS01770	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS01790	COG0415	Belongs to the DNA photolyase family
I6J71_RS01800	COG1668	transmembrane transport
I6J71_RS01805	COG4152	abc transporter atp-binding protein
I6J71_RS01820	COG0277	FAD linked oxidase domain protein
I6J71_RS01875	COG0395	ABC-type sugar transport system, permease component
I6J71_RS01880	COG1175	transmembrane transport
I6J71_RS01885	COG2182	Extracellular solute-binding protein
I6J71_RS01900	COG1169	isochorismate synthase
I6J71_RS01910	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS01925	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS01930	COG1024	Enoyl-CoA hydratase
I6J71_RS01950	COG1321	iron dependent repressor
I6J71_RS01970	COG1984	allophanate hydrolase subunit 2
I6J71_RS01975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_RS01980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_RS01985	COG4336	lyase activity
I6J71_RS01990	COG2814	Major facilitator Superfamily
I6J71_RS02000	COG3469	chitinase activity
I6J71_RS02025	COG1940	carbohydrate kinase activity
I6J71_RS02025	COG1846	Transcriptional regulator
I6J71_RS02030	COG4166	transmembrane transport
I6J71_RS02040	COG0601	transmembrane transport
I6J71_RS02045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS02050	COG0444	Belongs to the ABC transporter superfamily
I6J71_RS02110	COG1846	Transcriptional regulator
I6J71_RS02120	COG2755	lipolytic protein G-D-S-L family
I6J71_RS02120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6J71_RS02130	COG3511	phospholipase C
I6J71_RS02140	COG0583	DNA-binding transcription factor activity
I6J71_RS02145	COG0515	serine threonine protein kinase
I6J71_RS02150	COG1510	regulation of RNA biosynthetic process
I6J71_RS02155	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_RS02165	COG3285	dna ligase
I6J71_RS02165	COG1793	dna ligase
I6J71_RS02200	COG3903	Transcriptional regulator
I6J71_RS02200	COG3629	intracellular signal transduction
I6J71_RS02315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J71_RS02325	COG1131	(ABC) transporter
I6J71_RS02360	COG1131	(ABC) transporter
I6J71_RS02410	COG1131	(ABC) transporter
I6J71_RS02430	COG2197	response regulator
I6J71_RS02435	COG2860	membrane
I6J71_RS02450	COG1349	DNA-binding transcription factor activity
I6J71_RS02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_RS02475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J71_RS02495	COG0745	RESPONSE REGULATOR receiver
I6J71_RS02500	COG5002	protein histidine kinase activity
I6J71_RS02515	COG1131	(ABC) transporter
I6J71_RS02540	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J71_RS02540	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J71_RS02565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J71_RS02570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J71_RS02625	COG0629	single-stranded DNA binding
I6J71_RS02685	COG1793	dna ligase
I6J71_RS02715	COG0583	DNA-binding transcription factor activity
I6J71_RS02740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J71_RS02790	COG2258	MOSC domain
I6J71_RS02805	COG0596	Alpha beta hydrolase
I6J71_RS02815	COG0515	serine threonine protein kinase
I6J71_RS02825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J71_RS02875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J71_RS02880	COG0084	hydrolase, TatD family'
I6J71_RS02890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J71_RS02900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J71_RS02905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J71_RS02910	COG0488	(ABC) transporter
I6J71_RS02915	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS02925	COG0193	aminoacyl-tRNA hydrolase activity
I6J71_RS02965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J71_RS02990	COG0583	DNA-binding transcription factor activity
I6J71_RS03030	COG0586	Pfam SNARE associated Golgi protein
I6J71_RS03050	COG2133	pyrroloquinoline quinone binding
I6J71_RS03060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS03105	COG0134	indole-3-glycerol-phosphate synthase activity
I6J71_RS03120	COG1595	DNA-templated transcription, initiation
I6J71_RS03130	COG1131	(ABC) transporter
I6J71_RS03150	COG2837	iron assimilation
I6J71_RS03155	COG2822	iron ion transport
I6J71_RS03160	COG0672	)-iron permease
I6J71_RS03190	COG0148	phosphopyruvate hydratase activity
I6J71_RS03210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J71_RS03220	COG4166	transmembrane transport
I6J71_RS03225	COG0601	transmembrane transport
I6J71_RS03230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS03240	COG4608	Belongs to the ABC transporter superfamily
I6J71_RS03300	COG2124	cytochrome p450
I6J71_RS03315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J71_RS03325	COG1515	deoxyribonuclease V activity
I6J71_RS03335	COG1252	NADH dehydrogenase
I6J71_RS03340	COG2132	Multicopper oxidase
I6J71_RS03385	COG0135	phosphoribosylanthranilate isomerase activity
I6J71_RS03405	COG2368	4-hydroxyphenylacetate
I6J71_RS03465	COG0778	Nitroreductase
I6J71_RS03485	COG0583	DNA-binding transcription factor activity
I6J71_RS03495	COG3971	2-oxopent-4-enoate hydratase activity
I6J71_RS03500	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6J71_RS03505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_RS03530	COG3483	tryptophan 2,3-dioxygenase activity
I6J71_RS03540	COG0477	Major facilitator Superfamily
I6J71_RS03565	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS03595	COG1396	sequence-specific DNA binding
I6J71_RS03620	COG1136	(ABC) transporter
I6J71_RS03650	COG1316	TRANSCRIPTIONal
I6J71_RS03660	COG0671	phosphoesterase, PA-phosphatase related
I6J71_RS03755	COG0395	ABC-type sugar transport system, permease component
I6J71_RS03760	COG1175	transmembrane transport
I6J71_RS03780	COG0667	Aldo Keto reductase
I6J71_RS03785	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_RS03790	COG2197	response regulator
I6J71_RS03800	COG1175	transmembrane transport
I6J71_RS03810	COG2723	6-phospho-beta-galactosidase activity
I6J71_RS03820	COG3629	intracellular signal transduction
I6J71_RS03820	COG3903	Transcriptional regulator
I6J71_RS03860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J71_RS03895	COG0477	Major facilitator Superfamily
I6J71_RS03900	COG0183	Belongs to the thiolase family
I6J71_RS03940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J71_RS03975	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J71_RS03985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_RS03990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J71_RS04000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J71_RS04010	COG1331	Highly conserved protein containing a thioredoxin domain
I6J71_RS04060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J71_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS04130	COG1793	dna ligase
I6J71_RS04145	COG0114	fumarate hydratase activity
I6J71_RS04150	COG0492	ferredoxin-NADP+ reductase activity
I6J71_RS04165	COG1722	exodeoxyribonuclease VII activity
I6J71_RS04175	COG1570	exodeoxyribonuclease VII activity
I6J71_RS04185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J71_RS04200	COG0420	3'-5' exonuclease activity
I6J71_RS04205	COG0419	ATPase involved in DNA repair
I6J71_RS04215	COG0012	GTP binding
I6J71_RS04280	COG1725	Transcriptional regulator
I6J71_RS04305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J71_RS04310	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6J71_RS04325	COG3842	ATPase activity
I6J71_RS04335	COG1131	(ABC) transporter
I6J71_RS04345	COG0745	RESPONSE REGULATOR receiver
I6J71_RS04355	COG0406	alpha-ribazole phosphatase activity
I6J71_RS04355	COG0494	nUDIX hydrolase
I6J71_RS04360	COG0180	Tryptophanyl-tRNA synthetase
I6J71_RS04375	COG1217	gtp-binding protein TYPA
I6J71_RS04380	COG0747	negative chemotaxis
I6J71_RS04385	COG4608	Belongs to the ABC transporter superfamily
I6J71_RS04400	COG0601	transmembrane transport
I6J71_RS04405	COG4166	transmembrane transport
I6J71_RS04410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J71_RS04430	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_RS04445	COG1994	Peptidase M50
I6J71_RS04485	COG1482	cell wall glycoprotein biosynthetic process
I6J71_RS04495	COG0531	amino acid
I6J71_RS04540	COG0656	L-ascorbic acid biosynthetic process
I6J71_RS04570	COG2146	nitrite reductase [NAD(P)H] activity
I6J71_RS04575	COG0745	RESPONSE REGULATOR receiver
I6J71_RS04580	COG5002	protein histidine kinase activity
I6J71_RS04595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6J71_RS04600	COG0653	protein targeting
I6J71_RS04620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J71_RS04655	COG1162	GTPase activity
I6J71_RS04660	COG2135	peptidase activity
I6J71_RS04675	COG1595	DNA-templated transcription, initiation
I6J71_RS04680	COG5662	AntiSigma factor
I6J71_RS04695	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS04730	COG1597	lipid kinase activity
I6J71_RS04745	COG0406	alpha-ribazole phosphatase activity
I6J71_RS04755	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6J71_RS04760	COG0281	malic enzyme
I6J71_RS04805	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_RS04805	COG0567	Dehydrogenase, E1 component
I6J71_RS04820	COG1132	(ABC) transporter
I6J71_RS04825	COG0686	Belongs to the AlaDH PNT family
I6J71_RS04840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J71_RS04840	COG2508	Transcriptional regulator
I6J71_RS04850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_RS04855	COG2755	lipolytic protein G-D-S-L family
I6J71_RS04870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J71_RS04880	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS04895	COG4221	oxidoreductase activity
I6J71_RS04970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J71_RS04975	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS04980	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS04990	COG1309	transcriptional regulator
I6J71_RS04995	COG0183	Belongs to the thiolase family
I6J71_RS05000	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_RS05000	COG1024	Enoyl-CoA hydratase
I6J71_RS05010	COG2188	Transcriptional regulator
I6J71_RS05025	COG4260	virion core protein, lumpy skin disease virus
I6J71_RS05060	COG0028	Belongs to the TPP enzyme family
I6J71_RS05080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J71_RS05090	COG0473	3-isopropylmalate dehydrogenase activity
I6J71_RS05120	COG0154	amidase activity
I6J71_RS05165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS05170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J71_RS05230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_RS05270	COG1595	DNA-templated transcription, initiation
I6J71_RS05285	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS05370	COG2814	Major facilitator Superfamily
I6J71_RS05430	COG2188	Transcriptional regulator
I6J71_RS05570	COG0596	Alpha beta hydrolase
I6J71_RS05580	COG2755	lipolytic protein G-D-S-L family
I6J71_RS05590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J71_RS05605	COG0018	arginyl-trna synthetase
I6J71_RS05610	COG0019	diaminopimelate decarboxylase activity
I6J71_RS05615	COG0460	homoserine dehydrogenase
I6J71_RS05620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J71_RS05625	COG0083	homoserine kinase activity
I6J71_RS05635	COG0254	rRNA binding
I6J71_RS05640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J71_RS05660	COG0463	Glycosyl transferase, family 2
I6J71_RS05665	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_RS05685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J71_RS05700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J71_RS05705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J71_RS05715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J71_RS05720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J71_RS05725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J71_RS05730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J71_RS05760	COG1309	transcriptional regulator
I6J71_RS05765	COG1280	lysine exporter protein (LysE YggA)
I6J71_RS05785	COG0765	amino acid transport
I6J71_RS05790	COG0765	amino acid transport
I6J71_RS05795	COG1126	abc transporter atp-binding protein
I6J71_RS05810	COG1024	Enoyl-CoA hydratase
I6J71_RS05825	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6J71_RS05855	COG2376	Dihydroxyacetone kinase
I6J71_RS05865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J71_RS05870	COG1522	sequence-specific DNA binding
I6J71_RS05875	COG0626	cystathionine gamma-synthase activity
I6J71_RS05900	COG2267	carboxylic ester hydrolase activity
I6J71_RS05910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J71_RS05915	COG0560	Phosphoserine phosphatase
I6J71_RS05915	COG3830	Belongs to the UPF0237 family
I6J71_RS05950	COG1335	isochorismatase
I6J71_RS05955	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J71_RS05995	COG1794	racemase activity, acting on amino acids and derivatives
I6J71_RS06020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J71_RS06025	COG1234	tRNA 3'-trailer cleavage
I6J71_RS06030	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6J71_RS06035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J71_RS06075	COG2188	Transcriptional regulator
I6J71_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS06100	COG1295	ribonuclease BN
I6J71_RS06135	COG1316	TRANSCRIPTIONal
I6J71_RS06170	COG3844	kynureninase activity
I6J71_RS06185	COG2018	Roadblock/LC7 domain
I6J71_RS06200	COG2259	Doxx family
I6J71_RS06205	COG1051	belongs to the nudix hydrolase family
I6J71_RS06210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J71_RS06225	COG1408	metallophosphoesterase
I6J71_RS06245	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS06250	COG1063	alcohol dehydrogenase
I6J71_RS06255	COG0022	dehydrogenase e1 component
I6J71_RS06275	COG1309	transcriptional regulator
I6J71_RS06280	COG1024	Enoyl-CoA hydratase
I6J71_RS06305	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS06315	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS06345	COG1733	regulation of RNA biosynthetic process
I6J71_RS06370	COG0662	Cupin 2, conserved barrel domain protein
I6J71_RS06385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS06390	COG3383	formate dehydrogenase (NAD+) activity
I6J71_RS06400	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS06405	COG2909	trisaccharide binding
I6J71_RS06415	COG4335	DNA alkylation repair
I6J71_RS06420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J71_RS06440	COG1309	transcriptional regulator
I6J71_RS06450	COG3835	regulator
I6J71_RS06470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_RS06475	COG0590	tRNA wobble adenosine to inosine editing
I6J71_RS06480	COG2252	PERMEase
I6J71_RS06490	COG1929	Belongs to the glycerate kinase type-1 family
I6J71_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS06525	COG2837	iron assimilation
I6J71_RS06530	COG3511	phospholipase C
I6J71_RS06550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J71_RS06555	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J71_RS06560	COG1120	ATPase activity
I6J71_RS06565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J71_RS06590	COG3250	beta-galactosidase activity
I6J71_RS06600	COG3250	beta-galactosidase activity
I6J71_RS06620	COG2226	methyltransferase
I6J71_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS06695	COG0706	membrane insertase activity
I6J71_RS06760	COG0367	asparagine synthase
I6J71_RS06785	COG0789	Transcriptional regulator
I6J71_RS06830	COG1024	Enoyl-CoA hydratase
I6J71_RS06845	COG0242	peptide deformylase activity
I6J71_RS06880	COG3540	Alkaline phosphatase
I6J71_RS06910	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS06915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS06925	COG1595	DNA-templated transcription, initiation
I6J71_RS06985	COG3214	Protein conserved in bacteria
I6J71_RS06995	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_RS07025	COG1126	abc transporter atp-binding protein
I6J71_RS07030	COG4215	(ABC) transporter
I6J71_RS07045	COG2186	Transcriptional regulator
I6J71_RS07050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_RS07055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS07105	COG0583	DNA-binding transcription factor activity
I6J71_RS07115	COG0477	Major facilitator Superfamily
I6J71_RS07135	COG2072	flavoprotein involved in K transport
I6J71_RS07160	COG1234	tRNA 3'-trailer cleavage
I6J71_RS07180	COG1349	DNA-binding transcription factor activity
I6J71_RS07210	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS07215	COG1309	transcriptional regulator
I6J71_RS07220	COG0596	Alpha beta hydrolase
I6J71_RS07225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J71_RS07230	COG0765	amino acid transport
I6J71_RS07235	COG0765	amino acid transport
I6J71_RS07245	COG1126	abc transporter atp-binding protein
I6J71_RS07275	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS07280	COG0473	3-isopropylmalate dehydrogenase activity
I6J71_RS07290	COG1136	(ABC) transporter
I6J71_RS07295	COG1136	(ABC) transporter
I6J71_RS07345	COG4977	sequence-specific DNA binding
I6J71_RS07350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_RS07355	COG2079	MmgE PrpD family protein
I6J71_RS07370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS07385	COG4214	carbohydrate transport
I6J71_RS07395	COG0410	ABC transporter
I6J71_RS07410	COG1053	succinate dehydrogenase
I6J71_RS07415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_RS07455	COG1309	transcriptional regulator
I6J71_RS07460	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J71_RS07480	COG0596	Alpha beta hydrolase
I6J71_RS07515	COG4638	Rieske (2fe-2S)
I6J71_RS07530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J71_RS07530	COG0519	Catalyzes the synthesis of GMP from XMP
I6J71_RS07540	COG2814	Major facilitator Superfamily
I6J71_RS07575	COG0778	Nitroreductase
I6J71_RS07580	COG0657	acetylesterase activity
I6J71_RS07595	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_RS07640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_RS07640	COG1017	nitric oxide dioxygenase activity
I6J71_RS07650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J71_RS07655	COG1611	Belongs to the LOG family
I6J71_RS07665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J71_RS07670	COG1309	transcriptional regulator
I6J71_RS07690	COG1053	succinate dehydrogenase
I6J71_RS07715	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS07730	COG0514	ATP-dependent DNA helicase (RecQ)
I6J71_RS07745	COG0583	DNA-binding transcription factor activity
I6J71_RS07755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS07805	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS07820	COG0753	catalase activity
I6J71_RS07840	COG0583	DNA-binding transcription factor activity
I6J71_RS07850	COG0583	DNA-binding transcription factor activity
I6J71_RS07865	COG2814	Major facilitator Superfamily
I6J71_RS07870	COG2188	Transcriptional regulator
I6J71_RS07885	COG1984	allophanate hydrolase subunit 2
I6J71_RS07890	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_RS07895	COG0439	Biotin carboxylase
I6J71_RS07905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_RS07910	COG2508	Transcriptional regulator
I6J71_RS07935	COG2226	methyltransferase
I6J71_RS07965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J71_RS07995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_RS08025	COG0154	amidase activity
I6J71_RS08030	COG0154	amidase activity
I6J71_RS08065	COG4413	Urea transporter
I6J71_RS08080	COG3540	Alkaline phosphatase
I6J71_RS08115	COG0531	amino acid
I6J71_RS08165	COG3511	phospholipase C
I6J71_RS08300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J71_RS08310	COG0477	Major facilitator Superfamily
I6J71_RS08315	COG1609	Transcriptional regulator
I6J71_RS08325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J71_RS08475	COG2801	Transposase and inactivated derivatives
I6J71_RS08535	COG2801	Transposase and inactivated derivatives
I6J71_RS08600	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS08605	COG2814	Major facilitator Superfamily
I6J71_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS08645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J71_RS08650	COG4988	ABC transporter
I6J71_RS08660	COG1294	oxidase, subunit
I6J71_RS08665	COG1271	oxidase subunit
I6J71_RS08700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS08730	COG2267	carboxylic ester hydrolase activity
I6J71_RS08755	COG3483	tryptophan 2,3-dioxygenase activity
I6J71_RS08765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J71_RS08765	COG2226	methyltransferase
I6J71_RS08765	COG3433	isochorismatase activity
I6J71_RS08770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J71_RS08775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J71_RS08840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J71_RS08845	COG0433	COG0433 Predicted ATPase
I6J71_RS08855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_RS08865	COG2226	methyltransferase
I6J71_RS09035	COG4195	phage-related replication protein
I6J71_RS09090	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6J71_RS09105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J71_RS09110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J71_RS09110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J71_RS09115	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_RS09120	COG3469	chitinase activity
I6J71_RS09135	COG1476	TRANSCRIPTIONal
I6J71_RS09170	COG0778	Nitroreductase
I6J71_RS09205	COG1797	cobyrinic acid a,c-diamide synthase activity
I6J71_RS09215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6J71_RS09220	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6J71_RS09230	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J71_RS09235	COG1492	cobalamin metabolic process
I6J71_RS09245	COG2197	response regulator
I6J71_RS09250	COG3851	Histidine kinase
I6J71_RS09255	COG0308	aminopeptidase N
I6J71_RS09265	COG1733	regulation of RNA biosynthetic process
I6J71_RS09280	COG0069	glutamate synthase activity
I6J71_RS09280	COG0070	glutamate synthase
I6J71_RS09280	COG0067	glutamate synthase
I6J71_RS09285	COG1739	Uncharacterized protein family UPF0029
I6J71_RS09295	COG0277	FAD linked oxidase domain protein
I6J71_RS09295	COG0247	lactate metabolic process
I6J71_RS09330	COG2072	flavoprotein involved in K transport
I6J71_RS09350	COG2144	transferase activity, transferring acyl groups
I6J71_RS09355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS09365	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS09380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6J71_RS09380	COG0235	Class ii aldolase
I6J71_RS09390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J71_RS09400	COG1595	DNA-templated transcription, initiation
I6J71_RS09405	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_RS09450	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
I6J71_RS09545	COG1674	ftsk spoiiie
I6J71_RS09550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J71_RS09585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J71_RS09585	COG1796	DNA polymerase
I6J71_RS09605	COG3268	Saccharopine dehydrogenase
I6J71_RS09630	COG0475	glutathione-regulated potassium exporter activity
I6J71_RS09635	COG1643	Atp-dependent helicase
I6J71_RS09640	COG2207	Transcriptional regulator
I6J71_RS09645	COG0667	Aldo Keto reductase
I6J71_RS09680	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS09705	COG3971	2-oxopent-4-enoate hydratase activity
I6J71_RS09710	COG1024	Enoyl-CoA hydratase
I6J71_RS09715	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS09770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS09780	COG0642	Histidine kinase
I6J71_RS09790	COG1609	Transcriptional regulator
I6J71_RS09835	COG0747	negative chemotaxis
I6J71_RS09860	COG0366	Alpha amylase catalytic
I6J71_RS09880	COG1609	Transcriptional regulator
I6J71_RS09885	COG1414	Transcriptional regulator
I6J71_RS09935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
I6J71_RS09945	COG4221	oxidoreductase activity
I6J71_RS09950	COG2267	carboxylic ester hydrolase activity
I6J71_RS09990	COG1937	Protein conserved in bacteria
I6J71_RS10005	COG1285	pathogenesis
I6J71_RS10010	COG0009	L-threonylcarbamoyladenylate synthase
I6J71_RS10020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_RS10030	COG0477	Major facilitator Superfamily
I6J71_RS10040	COG4941	Belongs to the sigma-70 factor family
I6J71_RS10090	COG2801	Transposase and inactivated derivatives
I6J71_RS10110	COG1609	Transcriptional regulator
I6J71_RS10115	COG0738	Major facilitator superfamily
I6J71_RS10120	COG0588	phosphoglycerate mutase activity
I6J71_RS10140	COG2902	Dehydrogenase
I6J71_RS10170	COG0366	Alpha amylase catalytic
I6J71_RS10180	COG0668	transmembrane transport
I6J71_RS10195	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J71_RS10205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J71_RS10220	COG0698	ribose 5-phosphate isomerase
I6J71_RS10270	COG0789	Transcriptional regulator
I6J71_RS10275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS10290	COG0531	amino acid
I6J71_RS10310	COG0657	acetylesterase activity
I6J71_RS10320	COG1024	Enoyl-CoA hydratase
I6J71_RS10340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_RS10465	COG0693	protein deglycase activity
I6J71_RS10490	COG0656	L-ascorbic acid biosynthetic process
I6J71_RS10505	COG2409	Drug exporters of the RND superfamily
I6J71_RS10515	COG2409	Drug exporters of the RND superfamily
I6J71_RS10520	COG0017	Asparaginyl-tRNA synthetase
I6J71_RS10550	COG1129	ABC transporter
I6J71_RS10555	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS10560	COG1879	ABC-type sugar transport system periplasmic component
I6J71_RS10565	COG0673	inositol 2-dehydrogenase activity
I6J71_RS10590	COG1940	carbohydrate kinase activity
I6J71_RS10610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6J71_RS10620	COG4689	acetoacetate decarboxylase
I6J71_RS10625	COG1309	transcriptional regulator
I6J71_RS10630	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I6J71_RS10640	COG2271	Major facilitator Superfamily
I6J71_RS10645	COG2423	ornithine cyclodeaminase activity
I6J71_RS10650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J71_RS10660	COG3537	Alpha-1,2-mannosidase
I6J71_RS10710	COG2205	protein histidine kinase activity
I6J71_RS10720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_RS10725	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J71_RS10730	COG0740	serine-type endopeptidase activity
I6J71_RS10735	COG0740	serine-type endopeptidase activity
I6J71_RS10740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6J71_RS10760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J71_RS10800	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_RS10820	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS10825	COG1316	TRANSCRIPTIONal
I6J71_RS10840	COG0477	Major facilitator Superfamily
I6J71_RS10855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J71_RS10855	COG2124	cytochrome p450
I6J71_RS10865	COG0525	valine-tRNA ligase activity
I6J71_RS10895	COG2755	lipolytic protein G-D-S-L family
I6J71_RS10910	COG0285	dihydrofolate synthase activity
I6J71_RS10920	COG0596	Alpha beta hydrolase
I6J71_RS10935	COG0105	UTP biosynthetic process
I6J71_RS10950	COG1131	(ABC) transporter
I6J71_RS10980	COG1530	ribonuclease E activity
I6J71_RS10980	COG1530	ribonuclease E activity
I6J71_RS10985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J71_RS10995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J71_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS11020	COG0018	arginyl-trna synthetase
I6J71_RS11025	COG0477	Major facilitator Superfamily
I6J71_RS11035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J71_RS11040	COG0799	negative regulation of ribosome biogenesis
I6J71_RS11045	COG0406	alpha-ribazole phosphatase activity
I6J71_RS11050	COG2755	lipolytic protein G-D-S-L family
I6J71_RS11055	COG1307	EDD domain protein, DegV family
I6J71_RS11075	COG1555	photosystem II stabilization
I6J71_RS11085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J71_RS11095	COG0268	Binds directly to 16S ribosomal RNA
I6J71_RS11110	COG2226	methyltransferase
I6J71_RS11115	COG0481	GTPase activity
I6J71_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS11145	COG2070	2-Nitropropane dioxygenase
I6J71_RS11150	COG0531	amino acid
I6J71_RS11160	COG0604	alcohol dehydrogenase
I6J71_RS11170	COG4290	ribonuclease
I6J71_RS11180	COG1024	Enoyl-CoA hydratase
I6J71_RS11210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J71_RS11225	COG1309	transcriptional regulator
I6J71_RS11260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_RS11265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS11270	COG1953	Uracil, thiamine, allantoin
I6J71_RS11275	COG0745	RESPONSE REGULATOR receiver
I6J71_RS11280	COG2205	protein histidine kinase activity
I6J71_RS11305	COG0667	Aldo Keto reductase
I6J71_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS11360	COG0537	adenosine 5'-monophosphoramidase activity
I6J71_RS11370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J71_RS11385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J71_RS11410	COG1381	Involved in DNA repair and RecF pathway recombination
I6J71_RS11415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J71_RS11425	COG0701	Predicted permease
I6J71_RS11460	COG0423	glycine-tRNA ligase activity
I6J71_RS11465	COG1131	(ABC) transporter
I6J71_RS11475	COG4585	Histidine kinase
I6J71_RS11480	COG2197	response regulator
I6J71_RS11490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J71_RS11510	COG1595	DNA-templated transcription, initiation
I6J71_RS11525	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS11620	COG0248	Ppx GppA phosphatase
I6J71_RS11625	COG3285	dna ligase
I6J71_RS11625	COG1793	dna ligase
I6J71_RS11635	COG3655	Transcriptional regulator
I6J71_RS11645	COG0789	Transcriptional regulator
I6J71_RS11680	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6J71_RS11685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS11790	COG1940	carbohydrate kinase activity
I6J71_RS11795	COG0656	L-ascorbic acid biosynthetic process
I6J71_RS11800	COG2197	response regulator
I6J71_RS11805	COG3940	Belongs to the glycosyl hydrolase 43 family
I6J71_RS11835	COG1609	Transcriptional regulator
I6J71_RS11845	COG3250	beta-galactosidase activity
I6J71_RS11860	COG3408	Glycogen debranching enzyme
I6J71_RS11885	COG0477	Major facilitator Superfamily
I6J71_RS11920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_RS11930	COG0589	response to stress
I6J71_RS11955	COG0667	Aldo Keto reductase
I6J71_RS11995	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6J71_RS12000	COG1082	Xylose isomerase domain protein TIM barrel
I6J71_RS12005	COG1063	alcohol dehydrogenase
I6J71_RS12020	COG0395	ABC-type sugar transport system, permease component
I6J71_RS12025	COG1940	carbohydrate kinase activity
I6J71_RS12050	COG0702	epimerase
I6J71_RS12055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J71_RS12060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_RS12065	COG1595	DNA-templated transcription, initiation
I6J71_RS12070	COG1959	2 iron, 2 sulfur cluster binding
I6J71_RS12090	COG0583	DNA-binding transcription factor activity
I6J71_RS12120	COG2871	sodium ion transport
I6J71_RS12130	COG3485	protocatechuate 3,4-dioxygenase
I6J71_RS12135	COG1959	2 iron, 2 sulfur cluster binding
I6J71_RS12160	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS12175	COG0789	Transcriptional regulator
I6J71_RS12190	COG1414	Transcriptional regulator
I6J71_RS12205	COG2271	Major facilitator Superfamily
I6J71_RS12260	COG0477	Major facilitator Superfamily
I6J71_RS12270	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_RS12280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS12300	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_RS12305	COG3473	Maleate cis-trans isomerase
I6J71_RS12340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS12350	COG0628	permease
I6J71_RS12360	COG2909	trisaccharide binding
I6J71_RS12415	COG0604	alcohol dehydrogenase
I6J71_RS12440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_RS12445	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_RS12450	COG0154	amidase activity
I6J71_RS12465	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS12565	COG0492	ferredoxin-NADP+ reductase activity
I6J71_RS12565	COG3118	belongs to the thioredoxin family
I6J71_RS12580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J71_RS12590	COG1573	uracil-dna glycosylase
I6J71_RS12595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J71_RS12600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J71_RS12600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J71_RS12620	COG0667	Aldo Keto reductase
I6J71_RS12625	COG0477	Major facilitator Superfamily
I6J71_RS12650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J71_RS12655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J71_RS12675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J71_RS12770	COG2801	Transposase and inactivated derivatives
I6J71_RS12780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J71_RS12815	COG0778	Nitroreductase
I6J71_RS12820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_RS12830	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS12845	COG0604	alcohol dehydrogenase
I6J71_RS12875	COG1309	transcriptional regulator
I6J71_RS12880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J71_RS12885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_RS12900	COG1063	alcohol dehydrogenase
I6J71_RS12925	COG0697	spore germination
I6J71_RS12975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS12990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_RS13015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS13055	COG0583	DNA-binding transcription factor activity
I6J71_RS13095	COG1316	TRANSCRIPTIONal
I6J71_RS13120	COG5002	protein histidine kinase activity
I6J71_RS13155	COG0477	Major facilitator Superfamily
I6J71_RS13160	COG0726	polysaccharide deacetylase
I6J71_RS13180	COG1733	regulation of RNA biosynthetic process
I6J71_RS13190	COG2197	response regulator
I6J71_RS13210	COG3226	Transcriptional regulator
I6J71_RS13230	COG0546	phosphoglycolate phosphatase activity
I6J71_RS13250	COG0779	Required for maturation of 30S ribosomal subunits
I6J71_RS13265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J71_RS13275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J71_RS13300	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_RS13310	COG0384	phenazine biosynthesis protein PhzF
I6J71_RS13320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J71_RS13340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J71_RS13345	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J71_RS13355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J71_RS13385	COG3214	Protein conserved in bacteria
I6J71_RS13420	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_RS13430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J71_RS13435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J71_RS13450	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J71_RS13460	COG1674	ftsk spoiiie
I6J71_RS13470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J71_RS13475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6J71_RS13475	COG2755	lipolytic protein G-D-S-L family
I6J71_RS13485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J71_RS13495	COG1546	Belongs to the CinA family
I6J71_RS13495	COG1058	Belongs to the CinA family
I6J71_RS13500	COG1396	sequence-specific DNA binding
I6J71_RS13505	COG1842	Phage shock protein A
I6J71_RS13520	COG0167	dihydroorotate dehydrogenase activity
I6J71_RS13530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J71_RS13535	COG1192	Involved in chromosome partitioning
I6J71_RS13545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J71_RS13555	COG1305	Transglutaminase-like
I6J71_RS13565	COG0714	Associated with various cellular activities
I6J71_RS13590	COG1522	sequence-specific DNA binding
I6J71_RS13605	COG2001	Belongs to the MraZ family
I6J71_RS13610	COG0275	rRNA processing
I6J71_RS13620	COG0768	penicillin binding
I6J71_RS13635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J71_RS13640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J71_RS13650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J71_RS13655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J71_RS13670	COG2814	Major facilitator Superfamily
I6J71_RS13680	COG2318	DinB family
I6J71_RS13690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J71_RS13695	COG1496	oxidoreductase activity
I6J71_RS13700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J71_RS13705	COG1799	cell septum assembly
I6J71_RS13715	COG3599	regulation of cell shape
I6J71_RS13725	COG0640	Transcriptional regulator
I6J71_RS13730	COG0477	Major facilitator Superfamily
I6J71_RS13735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J71_RS13740	COG0768	penicillin binding
I6J71_RS13745	COG0640	Transcriptional regulator
I6J71_RS13755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_RS13765	COG5564	TIM-barrel signal transduction protein
I6J71_RS13770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J71_RS13775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J71_RS13800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS13805	COG0248	Ppx GppA phosphatase
I6J71_RS13835	COG1846	Transcriptional regulator
I6J71_RS13835	COG1940	carbohydrate kinase activity
I6J71_RS13850	COG0667	Aldo Keto reductase
I6J71_RS13865	COG0542	response to heat
I6J71_RS13875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J71_RS13885	COG0514	ATP-dependent DNA helicase (RecQ)
I6J71_RS13955	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J71_RS13965	COG2201	protein-glutamate methylesterase activity
I6J71_RS13970	COG4585	Histidine kinase
I6J71_RS13980	COG2197	response regulator
I6J71_RS13985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J71_RS14040	COG2814	Major facilitator Superfamily
I6J71_RS14050	COG1609	Transcriptional regulator
I6J71_RS14060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J71_RS14075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J71_RS14080	COG3285	dna ligase
I6J71_RS14080	COG1793	dna ligase
I6J71_RS14125	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J71_RS14135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J71_RS14145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J71_RS14155	COG3485	protocatechuate 3,4-dioxygenase
I6J71_RS14165	COG2197	response regulator
I6J71_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS14345	COG1801	Protein of unknown function DUF72
I6J71_RS14355	COG1511	domain protein
I6J71_RS14370	COG2226	methyltransferase
I6J71_RS14375	COG0539	negative regulation of cytoplasmic translation
I6J71_RS14400	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J71_RS14400	COG0237	dephospho-CoA kinase activity
I6J71_RS14405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J71_RS14415	COG2197	response regulator
I6J71_RS14430	COG1131	(ABC) transporter
I6J71_RS14460	COG1024	Enoyl-CoA hydratase
I6J71_RS14470	COG1131	(ABC) transporter
I6J71_RS14480	COG0823	Involved in the tonB-independent uptake of proteins
I6J71_RS14480	COG1506	peptidase
I6J71_RS14480	COG4946	Tricorn protease homolog
I6J71_RS14505	COG1609	Transcriptional regulator
I6J71_RS14510	COG1070	Carbohydrate kinase
I6J71_RS14535	COG0406	alpha-ribazole phosphatase activity
I6J71_RS14550	COG3012	SEC-C Motif Domain Protein
I6J71_RS14555	COG0328	RNA-DNA hybrid ribonuclease activity
I6J71_RS14570	COG1024	Enoyl-CoA hydratase
I6J71_RS14575	COG2368	4-hydroxyphenylacetate
I6J71_RS14595	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS14620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_RS14665	COG1301	dicarboxylic acid transport
I6J71_RS14670	COG3290	protein histidine kinase activity
I6J71_RS14675	COG4565	transcriptional regulatory protein
I6J71_RS14700	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6J71_RS14715	COG1414	Transcriptional regulator
I6J71_RS14720	COG0251	oxidation-reduction process
I6J71_RS14725	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J71_RS14745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J71_RS14750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J71_RS14755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J71_RS14760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J71_RS14765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J71_RS14765	COG0072	phenylalanine-tRNA ligase activity
I6J71_RS14780	COG2267	carboxylic ester hydrolase activity
I6J71_RS14800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J71_RS14805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J71_RS14810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J71_RS14815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J71_RS14820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J71_RS14825	COG1438	arginine binding
I6J71_RS14830	COG0137	argininosuccinate synthase activity
I6J71_RS14835	COG0165	Argininosuccinate lyase
I6J71_RS14840	COG2094	Belongs to the DNA glycosylase MPG family
I6J71_RS14845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J71_RS14875	COG0647	UMP catabolic process
I6J71_RS14890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J71_RS14990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J71_RS14995	COG0504	CTP synthase activity
I6J71_RS15000	COG0494	nUDIX hydrolase
I6J71_RS15020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J71_RS15035	COG2936	dipeptidyl-peptidase activity
I6J71_RS15040	COG0475	glutathione-regulated potassium exporter activity
I6J71_RS15060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J71_RS15070	COG1160	GTP binding
I6J71_RS15085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J71_RS15105	COG4977	sequence-specific DNA binding
I6J71_RS15110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J71_RS15115	COG1414	Transcriptional regulator
I6J71_RS15120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J71_RS15125	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS15140	COG5492	domain, Protein
I6J71_RS15160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J71_RS15165	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6J71_RS15175	COG0714	Associated with various cellular activities
I6J71_RS15190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J71_RS15235	COG0590	tRNA wobble adenosine to inosine editing
I6J71_RS15240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS15280	COG0778	Nitroreductase
I6J71_RS15295	COG1674	ftsk spoiiie
I6J71_RS15505	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_RS15515	COG0477	Major facilitator Superfamily
I6J71_RS15545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS15565	COG0778	Nitroreductase
I6J71_RS15675	COG1802	Transcriptional regulator
I6J71_RS15690	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS15705	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS15750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6J71_RS15755	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6J71_RS15760	COG0366	Alpha amylase catalytic
I6J71_RS15765	COG0366	Alpha amylase catalytic
I6J71_RS15775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J71_RS15810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_RS15815	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS15820	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_RS15875	COG1063	alcohol dehydrogenase
I6J71_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS15910	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_RS15915	COG1609	Transcriptional regulator
I6J71_RS15925	COG1175	transmembrane transport
I6J71_RS15930	COG0395	ABC-type sugar transport system, permease component
I6J71_RS15935	COG0129	dihydroxy-acid dehydratase activity
I6J71_RS15945	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_RS15975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J71_RS15980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J71_RS16025	COG2197	response regulator
I6J71_RS16045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS16045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS16060	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS16065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS16075	COG0154	amidase activity
I6J71_RS16085	COG1595	DNA-templated transcription, initiation
I6J71_RS16090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J71_RS16155	COG2267	carboxylic ester hydrolase activity
I6J71_RS16165	COG0577	efflux transmembrane transporter activity
I6J71_RS16165	COG1136	(ABC) transporter
I6J71_RS16170	COG0745	RESPONSE REGULATOR receiver
I6J71_RS16175	COG2205	protein histidine kinase activity
I6J71_RS16190	COG1940	carbohydrate kinase activity
I6J71_RS16195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J71_RS16210	COG0477	Major facilitator Superfamily
I6J71_RS16255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_RS16260	COG1595	DNA-templated transcription, initiation
I6J71_RS16320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J71_RS16325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J71_RS16345	COG1560	Kdo2-lipid A biosynthetic process
I6J71_RS16350	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS16360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6J71_RS16360	COG3608	succinylglutamate desuccinylase aspartoacylase
I6J71_RS16385	COG1396	sequence-specific DNA binding
I6J71_RS16390	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6J71_RS16395	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J71_RS16400	COG0217	transcriptional regulatory protein
I6J71_RS16425	COG2255	four-way junction helicase activity
I6J71_RS16430	COG1862	Preprotein translocase
I6J71_RS16440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J71_RS16445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J71_RS16450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J71_RS16475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_RS16550	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J71_RS16560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J71_RS16605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS16610	COG1609	Transcriptional regulator
I6J71_RS16650	COG2318	DinB family
I6J71_RS16700	COG1309	transcriptional regulator
I6J71_RS16705	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS16720	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS16720	COG2030	dehydratase
I6J71_RS16725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J71_RS16730	COG2301	Belongs to the HpcH HpaI aldolase family
I6J71_RS16740	COG4770	biotin carboxylase activity
I6J71_RS16745	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS16760	COG3485	protocatechuate 3,4-dioxygenase
I6J71_RS16770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS16775	COG1414	Transcriptional regulator
I6J71_RS16780	COG0402	S-adenosylhomocysteine deaminase activity
I6J71_RS16785	COG3285	dna ligase
I6J71_RS16785	COG1793	dna ligase
I6J71_RS16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_RS16810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J71_RS16910	COG0542	response to heat
I6J71_RS16940	COG0459	protein refolding
I6J71_RS16970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_RS17015	COG2172	sigma factor antagonist activity
I6J71_RS17075	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS17085	COG0640	Transcriptional regulator
I6J71_RS17090	COG3250	beta-galactosidase activity
I6J71_RS17095	COG1733	regulation of RNA biosynthetic process
I6J71_RS17110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J71_RS17115	COG2814	Major facilitator Superfamily
I6J71_RS17140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS17145	COG2358	TRAP transporter, solute receptor (TAXI family
I6J71_RS17160	COG1802	Transcriptional regulator
I6J71_RS17165	COG1802	Transcriptional regulator
I6J71_RS17170	COG0583	DNA-binding transcription factor activity
I6J71_RS17175	COG0163	prenyltransferase activity
I6J71_RS17210	COG2233	PERMEase
I6J71_RS17225	COG1414	Transcriptional regulator
I6J71_RS17240	COG2814	Major facilitator Superfamily
I6J71_RS17250	COG0456	acetyltransferase
I6J71_RS17260	COG0477	Major facilitator Superfamily
I6J71_RS17265	COG4638	Rieske (2fe-2S)
I6J71_RS17270	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J71_RS17335	COG2814	Major facilitator Superfamily
I6J71_RS17345	COG1609	Transcriptional regulator
I6J71_RS17350	COG1129	ABC transporter
I6J71_RS17355	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS17360	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS17380	COG3347	Dehydrogenase
I6J71_RS17390	COG1070	Carbohydrate kinase
I6J71_RS17395	COG0247	lactate metabolic process
I6J71_RS17400	COG1139	Iron-sulfur cluster binding protein
I6J71_RS17405	COG1556	Lactate utilization protein
I6J71_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS17465	COG1396	sequence-specific DNA binding
I6J71_RS17480	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS17490	COG1129	ABC transporter
I6J71_RS17520	COG1063	alcohol dehydrogenase
I6J71_RS17525	COG2084	Dehydrogenase
I6J71_RS17530	COG1672	PFAM Archaeal ATPase
I6J71_RS17530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_RS17535	COG2080	2 iron, 2 sulfur cluster binding
I6J71_RS17540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J71_RS17545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_RS17555	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS17610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_RS17610	COG0617	tRNA 3'-terminal CCA addition
I6J71_RS17610	COG0517	IMP dehydrogenase activity
I6J71_RS17645	COG0517	IMP dehydrogenase activity
I6J71_RS17645	COG0617	tRNA 3'-terminal CCA addition
I6J71_RS17645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_RS17675	COG3284	Transcriptional regulator
I6J71_RS17705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J71_RS17710	COG2814	Major facilitator Superfamily
I6J71_RS17715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_RS17770	COG0138	bifunctional purine biosynthesis protein purh
I6J71_RS17775	COG2080	2 iron, 2 sulfur cluster binding
I6J71_RS17780	COG2010	Cytochrome c
I6J71_RS17780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_RS17795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS17800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_RS17820	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS17820	COG2030	dehydratase
I6J71_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS17830	COG4670	ketone body catabolic process
I6J71_RS17835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS17850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J71_RS17870	COG3485	protocatechuate 3,4-dioxygenase
I6J71_RS17875	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS17880	COG0583	DNA-binding transcription factor activity
I6J71_RS17905	COG2188	Transcriptional regulator
I6J71_RS17910	COG1414	Transcriptional regulator
I6J71_RS17915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_RS17920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J71_RS17970	COG0235	Class ii aldolase
I6J71_RS17980	COG0683	leucine binding
I6J71_RS18075	COG1595	DNA-templated transcription, initiation
I6J71_RS18080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J71_RS18085	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_RS18115	COG2261	transglycosylase associated protein
I6J71_RS18155	COG1454	alcohol dehydrogenase
I6J71_RS18160	COG0824	Thioesterase
I6J71_RS18160	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_RS18185	COG1129	ABC transporter
I6J71_RS18190	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS18195	COG3284	Transcriptional regulator
I6J71_RS18225	COG0704	Plays a role in the regulation of phosphate uptake
I6J71_RS18230	COG0671	phosphoesterase, PA-phosphatase related
I6J71_RS18265	COG0583	DNA-binding transcription factor activity
I6J71_RS18295	COG1999	signal sequence binding
I6J71_RS18325	COG4941	Belongs to the sigma-70 factor family
I6J71_RS18340	COG0387	Pfam Sodium calcium exchanger
I6J71_RS18365	COG0028	Belongs to the TPP enzyme family
I6J71_RS18440	COG0651	ATP synthesis coupled electron transport
I6J71_RS18475	COG0709	Synthesizes selenophosphate from selenide and ATP
I6J71_RS18490	COG3276	selenocysteine insertion sequence binding
I6J71_RS18495	COG0243	molybdopterin cofactor binding
I6J71_RS18495	COG3383	formate dehydrogenase (NAD+) activity
I6J71_RS18500	COG0243	molybdopterin cofactor binding
I6J71_RS18500	COG3383	formate dehydrogenase (NAD+) activity
I6J71_RS18505	COG0437	4 iron, 4 sulfur cluster binding
I6J71_RS18535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J71_RS18600	COG2267	carboxylic ester hydrolase activity
I6J71_RS18620	COG2080	2 iron, 2 sulfur cluster binding
I6J71_RS18650	COG1993	acr, cog1993
I6J71_RS18655	COG1993	acr, cog1993
I6J71_RS18660	COG0515	serine threonine protein kinase
I6J71_RS18665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J71_RS18665	COG0515	serine threonine protein kinase
I6J71_RS18745	COG0488	(ABC) transporter
I6J71_RS18775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_RS18810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS18815	COG2211	Major facilitator Superfamily
I6J71_RS18830	COG0412	Dienelactone hydrolase
I6J71_RS18835	COG2814	Major facilitator Superfamily
I6J71_RS18845	COG0523	cobalamin synthesis protein
I6J71_RS18855	COG0254	rRNA binding
I6J71_RS18865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J71_RS18870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J71_RS18875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J71_RS18880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J71_RS18885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J71_RS18885	COG1648	precorrin-2 dehydrogenase activity
I6J71_RS18890	COG2267	carboxylic ester hydrolase activity
I6J71_RS18895	COG1024	Enoyl-CoA hydratase
I6J71_RS18900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_RS18925	COG1716	ATPase activity
I6J71_RS18960	COG0656	L-ascorbic acid biosynthetic process
I6J71_RS18975	COG1253	flavin adenine dinucleotide binding
I6J71_RS19020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J71_RS19025	COG0583	DNA-binding transcription factor activity
I6J71_RS19030	COG3572	ergothioneine biosynthetic process
I6J71_RS19035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J71_RS19040	COG0121	glutamine amidotransferase
I6J71_RS19045	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6J71_RS19070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J71_RS19075	COG3883	PFAM NLP P60 protein
I6J71_RS19075	COG0791	NLP P60 protein
I6J71_RS19095	COG0714	Associated with various cellular activities
I6J71_RS19105	COG2304	oxidoreductase activity
I6J71_RS19110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J71_RS19125	COG2205	protein histidine kinase activity
I6J71_RS19130	COG0745	RESPONSE REGULATOR receiver
I6J71_RS19135	COG0477	Major facilitator Superfamily
I6J71_RS19145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J71_RS19155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS19160	COG1024	Enoyl-CoA hydratase
I6J71_RS19170	COG1982	Orn Lys Arg decarboxylase major
I6J71_RS19175	COG0243	molybdopterin cofactor binding
I6J71_RS19260	COG0723	plastoquinol--plastocyanin reductase activity
I6J71_RS19265	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_RS19280	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J71_RS19290	COG0300	oxidoreductase activity
I6J71_RS19360	COG0596	Alpha beta hydrolase
I6J71_RS19370	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I6J71_RS19410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6J71_RS19425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J71_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS19440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J71_RS19440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6J71_RS19445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6J71_RS19450	COG2192	nodulation
I6J71_RS19475	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS19525	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS19550	COG0248	Ppx GppA phosphatase
I6J71_RS19560	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS19570	COG0277	FAD linked oxidase domain protein
I6J71_RS19570	COG0247	lactate metabolic process
I6J71_RS19575	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS19580	COG0028	Belongs to the TPP enzyme family
I6J71_RS19590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS19595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS19625	COG2814	Major facilitator Superfamily
I6J71_RS19635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J71_RS19645	COG0477	Major facilitator Superfamily
I6J71_RS19655	COG2159	amidohydrolase
I6J71_RS19665	COG1609	Transcriptional regulator
I6J71_RS19675	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS19680	COG0366	Alpha amylase catalytic
I6J71_RS19725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J71_RS19740	COG1595	DNA-templated transcription, initiation
I6J71_RS19775	COG0681	Belongs to the peptidase S26 family
I6J71_RS19785	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6J71_RS19795	COG1024	Enoyl-CoA hydratase
I6J71_RS19800	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_RS19815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_RS19815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_RS19820	COG1620	l-lactate permease
I6J71_RS19830	COG2186	Transcriptional regulator
I6J71_RS19840	COG3842	ATPase activity
I6J71_RS19845	COG1175	transmembrane transport
I6J71_RS19855	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6J71_RS19880	COG2153	protein acetylation
I6J71_RS19920	COG3226	Transcriptional regulator
I6J71_RS19925	COG4638	Rieske (2fe-2S)
I6J71_RS19970	COG4221	oxidoreductase activity
I6J71_RS19985	COG0395	ABC-type sugar transport system, permease component
I6J71_RS19990	COG1175	transmembrane transport
I6J71_RS19995	COG2182	Extracellular solute-binding protein
I6J71_RS20000	COG4991	sh3 domain protein
I6J71_RS20035	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_RS20055	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS20090	COG2267	carboxylic ester hydrolase activity
I6J71_RS20125	COG0583	DNA-binding transcription factor activity
I6J71_RS20130	COG0028	Belongs to the TPP enzyme family
I6J71_RS20145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J71_RS20150	COG1053	succinate dehydrogenase
I6J71_RS20165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_RS20170	COG2223	nitrite transmembrane transporter activity
I6J71_RS20175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J71_RS20185	COG0583	DNA-binding transcription factor activity
I6J71_RS20230	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J71_RS20240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS20260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J71_RS20265	COG3383	formate dehydrogenase (NAD+) activity
I6J71_RS20285	COG3622	Belongs to the hyi family
I6J71_RS20290	COG2084	Dehydrogenase
I6J71_RS20295	COG3960	tartronate-semialdehyde synthase activity
I6J71_RS20315	COG1846	Transcriptional regulator
I6J71_RS20330	COG0730	response to heat
I6J71_RS20360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_RS20385	COG1793	dna ligase
I6J71_RS20385	COG3285	dna ligase
I6J71_RS20395	COG0183	Belongs to the thiolase family
I6J71_RS20425	COG0583	DNA-binding transcription factor activity
I6J71_RS20430	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6J71_RS20455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS20465	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_RS20475	COG1309	transcriptional regulator
I6J71_RS20485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS20495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J71_RS20525	COG0667	Aldo Keto reductase
I6J71_RS20530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS20535	COG1968	undecaprenyl-diphosphatase activity
I6J71_RS20545	COG0339	signal peptide processing
I6J71_RS20555	COG0039	L-malate dehydrogenase activity
I6J71_RS20585	COG3537	Alpha-1,2-mannosidase
I6J71_RS20595	COG0154	amidase activity
I6J71_RS20600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J71_RS20605	COG2362	D-Aminopeptidase
I6J71_RS20615	COG0601	transmembrane transport
I6J71_RS20620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS20650	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J71_RS20690	COG0477	Major facilitator Superfamily
I6J71_RS20700	COG0346	lactoylglutathione lyase activity
I6J71_RS20705	COG0640	Transcriptional regulator
I6J71_RS20715	COG1309	transcriptional regulator
I6J71_RS20735	COG1357	PFAM Pentapeptide repeats (8 copies)
I6J71_RS20740	COG4974	Belongs to the 'phage' integrase family
I6J71_RS20765	COG0740	serine-type endopeptidase activity
I6J71_RS20805	COG0596	Alpha beta hydrolase
I6J71_RS20810	COG4941	Belongs to the sigma-70 factor family
I6J71_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS20835	COG2226	methyltransferase
I6J71_RS20840	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS20845	COG1309	transcriptional regulator
I6J71_RS20855	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS20860	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS20865	COG4941	Belongs to the sigma-70 factor family
I6J71_RS20870	COG3795	YCII-related domain
I6J71_RS20875	COG4974	Belongs to the 'phage' integrase family
I6J71_RS20880	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS20905	COG1435	thymidine kinase activity
I6J71_RS20915	COG0463	Glycosyl transferase, family 2
I6J71_RS20925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_RS20940	COG3973	AAA domain
I6J71_RS20965	COG4941	Belongs to the sigma-70 factor family
I6J71_RS21020	COG0702	epimerase
I6J71_RS21030	COG4552	Acetyltransferase involved in intracellular survival and related
I6J71_RS21040	COG4552	Acetyltransferase involved in intracellular survival and related
I6J71_RS21055	COG1597	lipid kinase activity
I6J71_RS21065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J71_RS21075	COG2378	regulation of single-species biofilm formation
I6J71_RS21085	COG4221	oxidoreductase activity
I6J71_RS21095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J71_RS21100	COG1597	lipid kinase activity
I6J71_RS21110	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J71_RS21115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6J71_RS21155	COG1222	aaa ATPase
I6J71_RS21175	COG0517	IMP dehydrogenase activity
I6J71_RS21175	COG1994	Peptidase M50
I6J71_RS21190	COG1192	Involved in chromosome partitioning
I6J71_RS21195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J71_RS21200	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J71_RS21220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J71_RS21240	COG0488	(ABC) transporter
I6J71_RS21245	COG0215	cysteine-tRNA ligase activity
I6J71_RS21260	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I6J71_RS21280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J71_RS21485	COG2080	2 iron, 2 sulfur cluster binding
I6J71_RS21490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J71_RS21495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_RS21525	COG2208	phosphoserine phosphatase activity
I6J71_RS21525	COG2770	Histidine kinase
I6J71_RS21545	COG1073	alpha beta
I6J71_RS21560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS21635	COG2814	Major facilitator Superfamily
I6J71_RS21660	COG3158	transport of potassium into the cell
I6J71_RS21675	COG5285	phytanoyl-CoA dioxygenase
I6J71_RS21700	COG0640	Transcriptional regulator
I6J71_RS21750	COG1968	undecaprenyl-diphosphatase activity
I6J71_RS21775	COG3848	Pyruvate phosphate dikinase
I6J71_RS21775	COG0574	Belongs to the PEP-utilizing enzyme family
I6J71_RS21780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J71_RS21800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J71_RS21850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS21895	COG0739	heme binding
I6J71_RS21925	COG0778	Nitroreductase
I6J71_RS21935	COG4221	oxidoreductase activity
I6J71_RS21940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_RS21945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_RS21950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J71_RS21990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_RS21995	COG0395	ABC-type sugar transport system, permease component
I6J71_RS22005	COG2205	protein histidine kinase activity
I6J71_RS22060	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS22100	COG2197	response regulator
I6J71_RS22105	COG2197	response regulator
I6J71_RS22155	COG4221	oxidoreductase activity
I6J71_RS22175	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J71_RS22180	COG0477	Major facilitator Superfamily
I6J71_RS22185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_RS22205	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS22230	COG0642	Histidine kinase
I6J71_RS22270	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS22275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J71_RS22285	COG0586	Pfam SNARE associated Golgi protein
I6J71_RS22305	COG3383	formate dehydrogenase (NAD+) activity
I6J71_RS22330	COG0477	Major facilitator Superfamily
I6J71_RS22340	COG4214	carbohydrate transport
I6J71_RS22345	COG1129	ABC transporter
I6J71_RS22355	COG2160	L-arabinose isomerase activity
I6J71_RS22370	COG1609	Transcriptional regulator
I6J71_RS22390	COG1846	Transcriptional regulator
I6J71_RS22415	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS22420	COG1024	Enoyl-CoA hydratase
I6J71_RS22425	COG1620	l-lactate permease
I6J71_RS22435	COG2814	Major facilitator Superfamily
I6J71_RS22445	COG1802	Transcriptional regulator
I6J71_RS22450	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS22465	COG1301	dicarboxylic acid transport
I6J71_RS22515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_RS22515	COG0617	tRNA 3'-terminal CCA addition
I6J71_RS22515	COG0517	IMP dehydrogenase activity
I6J71_RS22520	COG2326	polyphosphate kinase activity
I6J71_RS22580	COG1309	transcriptional regulator
I6J71_RS22585	COG2124	cytochrome p450
I6J71_RS22585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J71_RS22590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_RS22630	COG1271	oxidase subunit
I6J71_RS22640	COG3387	PFAM Glycoside hydrolase 15-related
I6J71_RS22645	COG1252	NADH dehydrogenase
I6J71_RS22675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J71_RS22690	COG1595	DNA-templated transcription, initiation
I6J71_RS22705	COG0427	acetyl-CoA hydrolase
I6J71_RS22730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J71_RS22735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS22740	COG1064	alcohol dehydrogenase
I6J71_RS22745	COG0477	Major facilitator Superfamily
I6J71_RS22765	COG0477	Major facilitator Superfamily
I6J71_RS22770	COG4585	Histidine kinase
I6J71_RS22775	COG2197	response regulator
I6J71_RS22790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J71_RS22880	COG2771	luxR family
I6J71_RS22890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J71_RS22900	COG0535	radical SAM domain protein
I6J71_RS22905	COG0535	radical SAM domain protein
I6J71_RS22915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J71_RS22935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J71_RS22955	COG3629	intracellular signal transduction
I6J71_RS22955	COG3903	Transcriptional regulator
I6J71_RS23060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J71_RS23065	COG4208	sulfate ABC transporter
I6J71_RS23070	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J71_RS23075	COG0024	Methionine aminopeptidase
I6J71_RS23085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS23095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J71_RS23105	COG1733	regulation of RNA biosynthetic process
I6J71_RS23110	COG1017	nitric oxide dioxygenase activity
I6J71_RS23110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_RS23125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_RS23135	COG4221	oxidoreductase activity
I6J71_RS23140	COG0583	DNA-binding transcription factor activity
I6J71_RS23155	COG2080	2 iron, 2 sulfur cluster binding
I6J71_RS23160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6J71_RS23165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_RS23235	COG1584	GPR1 FUN34 yaaH family protein
I6J71_RS23240	COG1620	l-lactate permease
I6J71_RS23245	COG0247	lactate metabolic process
I6J71_RS23250	COG0277	FAD linked oxidase domain protein
I6J71_RS23255	COG0277	FAD linked oxidase domain protein
I6J71_RS23310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J71_RS23330	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6J71_RS23340	COG0517	IMP dehydrogenase activity
I6J71_RS23340	COG0617	tRNA 3'-terminal CCA addition
I6J71_RS23340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J71_RS23385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_RS23390	COG1116	anion transmembrane transporter activity
I6J71_RS23415	COG2066	Belongs to the glutaminase family
I6J71_RS23435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_RS23465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J71_RS23505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_RS23505	COG1116	anion transmembrane transporter activity
I6J71_RS23510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS23515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS23525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J71_RS23545	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_RS23550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_RS23580	COG0154	amidase activity
I6J71_RS23605	COG2226	methyltransferase
I6J71_RS23620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J71_RS23625	COG2301	Belongs to the HpcH HpaI aldolase family
I6J71_RS23630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS23635	COG2271	Major facilitator Superfamily
I6J71_RS23655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS23695	COG2267	carboxylic ester hydrolase activity
I6J71_RS23795	COG0657	acetylesterase activity
I6J71_RS23830	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_RS23835	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6J71_RS23840	COG2084	Dehydrogenase
I6J71_RS23860	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J71_RS23865	COG3842	ATPase activity
I6J71_RS23900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J71_RS23910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS23915	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J71_RS23920	COG2186	Transcriptional regulator
I6J71_RS23935	COG2159	amidohydrolase
I6J71_RS23940	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J71_RS23945	COG1063	alcohol dehydrogenase
I6J71_RS23955	COG0698	ribose 5-phosphate isomerase
I6J71_RS23960	COG0588	phosphoglycerate mutase activity
I6J71_RS23965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_RS23970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J71_RS23990	COG1132	(ABC) transporter
I6J71_RS24010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J71_RS24015	COG0477	Major facilitator Superfamily
I6J71_RS24025	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS24045	COG0252	asparaginase activity
I6J71_RS24050	COG1609	Transcriptional regulator
I6J71_RS24065	COG1113	amino acid transport
I6J71_RS24070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J71_RS24075	COG1228	amidohydrolase
I6J71_RS24085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS24170	COG0601	transmembrane transport
I6J71_RS24175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS24180	COG4172	Belongs to the ABC transporter superfamily
I6J71_RS24185	COG3119	arylsulfatase activity
I6J71_RS24190	COG1940	carbohydrate kinase activity
I6J71_RS24200	COG2315	Protein conserved in bacteria
I6J71_RS24270	COG4447	cellulose binding
I6J71_RS24290	COG0583	DNA-binding transcription factor activity
I6J71_RS24305	COG2124	cytochrome p450
I6J71_RS24335	COG3293	Transposase
I6J71_RS24360	COG0604	alcohol dehydrogenase
I6J71_RS24380	COG2814	Major facilitator Superfamily
I6J71_RS24390	COG2188	Transcriptional regulator
I6J71_RS24400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_RS24505	COG0142	geranyltranstransferase activity
I6J71_RS24530	COG2226	methyltransferase
I6J71_RS24535	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I6J71_RS24560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J71_RS24570	COG2801	Transposase and inactivated derivatives
I6J71_RS24575	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_RS24680	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS24690	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS24700	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
I6J71_RS24715	COG3118	belongs to the thioredoxin family
I6J71_RS24715	COG0492	ferredoxin-NADP+ reductase activity
I6J71_RS24725	COG2814	Major facilitator Superfamily
I6J71_RS24730	COG0656	L-ascorbic acid biosynthetic process
I6J71_RS24745	COG2815	serine threonine protein kinase
I6J71_RS24745	COG0515	serine threonine protein kinase
I6J71_RS24785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_RS24820	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS24865	COG0515	serine threonine protein kinase
I6J71_RS24885	COG0515	serine threonine protein kinase
I6J71_RS24950	COG4566	intracellular signal transduction
I6J71_RS24965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J71_RS25000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_RS25035	COG4585	Histidine kinase
I6J71_RS25040	COG2197	response regulator
I6J71_RS25130	COG1140	nitrate reductase beta subunit
I6J71_RS25135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6J71_RS25185	COG2132	Multicopper oxidase
I6J71_RS25195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_RS25215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_RS25275	COG0587	DNA-directed DNA polymerase activity
I6J71_RS25285	COG0667	Aldo Keto reductase
I6J71_RS25385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J71_RS25385	COG0515	serine threonine protein kinase
I6J71_RS25490	COG0121	glutamine amidotransferase
I6J71_RS25545	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS25575	COG2079	MmgE PrpD family protein
I6J71_RS25580	COG1309	transcriptional regulator
I6J71_RS25610	COG1309	transcriptional regulator
I6J71_RS25615	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS25620	COG1024	Enoyl-CoA hydratase
I6J71_RS25630	COG0427	acetyl-CoA hydrolase
I6J71_RS25635	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS25650	COG0183	Belongs to the thiolase family
I6J71_RS25675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS25675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS25690	COG1129	ABC transporter
I6J71_RS25700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS25705	COG4608	Belongs to the ABC transporter superfamily
I6J71_RS25710	COG0444	Belongs to the ABC transporter superfamily
I6J71_RS25730	COG2843	Capsule synthesis protein
I6J71_RS25765	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS25780	COG0535	radical SAM domain protein
I6J71_RS25795	COG3878	Protein conserved in bacteria
I6J71_RS25840	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J71_RS25845	COG0798	PFAM Bile acid sodium symporter
I6J71_RS25850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J71_RS25855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J71_RS25860	COG0640	Transcriptional regulator
I6J71_RS25900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J71_RS25915	COG1063	alcohol dehydrogenase
I6J71_RS25920	COG0516	GMP reductase activity
I6J71_RS25920	COG0517	IMP dehydrogenase activity
I6J71_RS25930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J71_RS25930	COG0574	Belongs to the PEP-utilizing enzyme family
I6J71_RS25935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J71_RS25945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J71_RS25950	COG1042	CoA-binding domain protein
I6J71_RS25950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J71_RS25950	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J71_RS26000	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS26095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6J71_RS26110	COG1993	acr, cog1993
I6J71_RS26195	COG0165	Argininosuccinate lyase
I6J71_RS26200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_RS26205	COG0129	dihydroxy-acid dehydratase activity
I6J71_RS26225	COG2197	response regulator
I6J71_RS26230	COG2072	flavoprotein involved in K transport
I6J71_RS26320	COG1733	regulation of RNA biosynthetic process
I6J71_RS26350	COG1309	transcriptional regulator
I6J71_RS26370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J71_RS26375	COG0142	geranyltranstransferase activity
I6J71_RS26385	COG0142	geranyltranstransferase activity
I6J71_RS26485	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6J71_RS26490	COG1335	isochorismatase
I6J71_RS26495	COG2259	Doxx family
I6J71_RS26540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J71_RS26620	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS26755	COG2801	Transposase and inactivated derivatives
I6J71_RS26830	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_RS26885	COG1082	Xylose isomerase domain protein TIM barrel
I6J71_RS26885	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J71_RS26895	COG3976	FMN-binding domain protein
I6J71_RS26895	COG1053	succinate dehydrogenase
I6J71_RS26900	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS26905	COG0583	DNA-binding transcription factor activity
I6J71_RS26910	COG0477	Major facilitator Superfamily
I6J71_RS26915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS26920	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS26935	COG0129	dihydroxy-acid dehydratase activity
I6J71_RS26975	COG4249	Peptidase C14 caspase catalytic subunit p20
I6J71_RS27060	COG1674	ftsk spoiiie
I6J71_RS27075	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS27100	COG2124	cytochrome p450
I6J71_RS27110	COG1024	Enoyl-CoA hydratase
I6J71_RS27120	COG0439	Biotin carboxylase
I6J71_RS27125	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS27135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS27140	COG0562	UDP-galactopyranose mutase
I6J71_RS27160	COG2124	cytochrome p450
I6J71_RS27165	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J71_RS27185	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS27190	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS27205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J71_RS27230	COG1414	Transcriptional regulator
I6J71_RS27245	COG0410	ABC transporter
I6J71_RS27275	COG1946	Acyl-CoA thioesterase
I6J71_RS27280	COG2030	dehydratase
I6J71_RS27285	COG2030	dehydratase
I6J71_RS27300	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS27305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J71_RS27315	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS27320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS27325	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_RS27330	COG0183	Belongs to the thiolase family
I6J71_RS27335	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J71_RS27350	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS27400	COG2197	response regulator
I6J71_RS27420	COG0583	DNA-binding transcription factor activity
I6J71_RS27425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J71_RS27460	COG0367	asparagine synthase
I6J71_RS27470	COG2124	cytochrome p450
I6J71_RS27480	COG2226	methyltransferase
I6J71_RS27490	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS27505	COG0477	Major facilitator Superfamily
I6J71_RS27570	COG0477	Major facilitator Superfamily
I6J71_RS27645	COG1309	transcriptional regulator
I6J71_RS27660	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS27680	COG1309	transcriptional regulator
I6J71_RS27685	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS27695	COG1309	transcriptional regulator
I6J71_RS27700	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J71_RS27715	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS27720	COG1228	amidohydrolase
I6J71_RS27730	COG2186	Transcriptional regulator
I6J71_RS27740	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS27760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J71_RS27770	COG1595	DNA-templated transcription, initiation
I6J71_RS27790	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_RS27795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J71_RS27825	COG0596	Alpha beta hydrolase
I6J71_RS27830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J71_RS27830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J71_RS27850	COG2301	Belongs to the HpcH HpaI aldolase family
I6J71_RS27855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS27860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J71_RS27865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J71_RS27890	COG1175	transmembrane transport
I6J71_RS27895	COG1609	Transcriptional regulator
I6J71_RS27900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J71_RS27920	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J71_RS27950	COG2367	Beta-lactamase
I6J71_RS27960	COG2367	Beta-lactamase
I6J71_RS27980	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS27990	COG1301	dicarboxylic acid transport
I6J71_RS28025	COG1216	Glycosyl transferase, family 2
I6J71_RS28035	COG4106	trans-aconitate 2-methyltransferase activity
I6J71_RS28045	COG3387	PFAM Glycoside hydrolase 15-related
I6J71_RS28050	COG0477	Major facilitator Superfamily
I6J71_RS28100	COG4221	oxidoreductase activity
I6J71_RS28115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J71_RS28125	COG1609	Transcriptional regulator
I6J71_RS28145	COG0167	dihydroorotate dehydrogenase activity
I6J71_RS28150	COG2814	Major facilitator Superfamily
I6J71_RS28180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_RS28200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J71_RS28205	COG3938	Belongs to the proline racemase family
I6J71_RS28215	COG1846	Transcriptional regulator
I6J71_RS28220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J71_RS28235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J71_RS28265	COG1309	transcriptional regulator
I6J71_RS28275	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS28280	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS28285	COG2814	Major facilitator Superfamily
I6J71_RS28300	COG4585	Histidine kinase
I6J71_RS28315	COG0459	protein refolding
I6J71_RS28320	COG1063	alcohol dehydrogenase
I6J71_RS28345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_RS28385	COG3511	phospholipase C
I6J71_RS28410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J71_RS28430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J71_RS28440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J71_RS28450	COG1126	abc transporter atp-binding protein
I6J71_RS28455	COG0765	amino acid transport
I6J71_RS28465	COG1802	Transcriptional regulator
I6J71_RS28500	COG0601	transmembrane transport
I6J71_RS28505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS28510	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS28525	COG4608	Belongs to the ABC transporter superfamily
I6J71_RS28535	COG1802	Transcriptional regulator
I6J71_RS28550	COG1672	PFAM Archaeal ATPase
I6J71_RS28550	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_RS28555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J71_RS28560	COG0277	FAD linked oxidase domain protein
I6J71_RS28565	COG2814	Major facilitator Superfamily
I6J71_RS28570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS28575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS28600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_RS28600	COG1116	anion transmembrane transporter activity
I6J71_RS28605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS28625	COG2197	response regulator
I6J71_RS28630	COG3629	intracellular signal transduction
I6J71_RS28630	COG3903	Transcriptional regulator
I6J71_RS28635	COG0739	heme binding
I6J71_RS28660	COG2197	response regulator
I6J71_RS28675	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6J71_RS28695	COG3237	CsbD-like
I6J71_RS28730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J71_RS28735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J71_RS28745	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J71_RS28750	COG0697	spore germination
I6J71_RS28765	COG3835	regulator
I6J71_RS28790	COG1657	PFAM Prenyltransferase squalene oxidase
I6J71_RS28805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_RS28805	COG2010	Cytochrome c
I6J71_RS28810	COG2080	2 iron, 2 sulfur cluster binding
I6J71_RS28830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_RS28840	COG1764	response to oxidative stress
I6J71_RS28870	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS28880	COG1132	(ABC) transporter
I6J71_RS28930	COG1349	DNA-binding transcription factor activity
I6J71_RS28935	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS28965	COG0583	DNA-binding transcription factor activity
I6J71_RS28990	COG2423	ornithine cyclodeaminase activity
I6J71_RS29015	COG0300	oxidoreductase activity
I6J71_RS29025	COG4221	oxidoreductase activity
I6J71_RS29050	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_RS29075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J71_RS29090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J71_RS29095	COG0587	DNA-directed DNA polymerase activity
I6J71_RS29110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J71_RS29115	COG2814	Major facilitator Superfamily
I6J71_RS29140	COG2368	4-hydroxyphenylacetate
I6J71_RS29165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS29170	COG1116	anion transmembrane transporter activity
I6J71_RS29170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J71_RS29185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J71_RS29195	COG3618	amidohydrolase
I6J71_RS29200	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6J71_RS29215	COG0473	3-isopropylmalate dehydrogenase activity
I6J71_RS29225	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6J71_RS29225	COG1082	Xylose isomerase domain protein TIM barrel
I6J71_RS29230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J71_RS29235	COG1309	transcriptional regulator
I6J71_RS29245	COG0477	Major facilitator Superfamily
I6J71_RS29255	COG4336	lyase activity
I6J71_RS29260	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J71_RS29265	COG1402	creatininase
I6J71_RS29270	COG2188	Transcriptional regulator
I6J71_RS29275	COG2814	Major facilitator Superfamily
I6J71_RS29285	COG0667	Aldo Keto reductase
I6J71_RS29300	COG4941	Belongs to the sigma-70 factor family
I6J71_RS29350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS29355	COG0601	transmembrane transport
I6J71_RS29375	COG0583	DNA-binding transcription factor activity
I6J71_RS29390	COG0148	phosphopyruvate hydratase activity
I6J71_RS29395	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6J71_RS29400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6J71_RS29405	COG3639	organic phosphonate transmembrane transporter activity
I6J71_RS29425	COG3626	phosphonate metabolism
I6J71_RS29430	COG3627	carbon phosphorus lyase activity
I6J71_RS29440	COG3454	Phosphonate metabolism
I6J71_RS29480	COG2814	Major facilitator Superfamily
I6J71_RS29480	COG0477	Major facilitator Superfamily
I6J71_RS29485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS29490	COG1846	Transcriptional regulator
I6J71_RS29500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J71_RS29525	COG1335	isochorismatase
I6J71_RS29550	COG2264	protein methyltransferase activity
I6J71_RS29560	COG2423	ornithine cyclodeaminase activity
I6J71_RS29565	COG3938	Belongs to the proline racemase family
I6J71_RS29575	COG0477	Major facilitator Superfamily
I6J71_RS29585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS29610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J71_RS29650	COG2124	cytochrome p450
I6J71_RS29655	COG1309	transcriptional regulator
I6J71_RS29695	COG0745	RESPONSE REGULATOR receiver
I6J71_RS29700	COG2205	protein histidine kinase activity
I6J71_RS29710	COG2223	nitrite transmembrane transporter activity
I6J71_RS29720	COG0673	inositol 2-dehydrogenase activity
I6J71_RS29750	COG2186	Transcriptional regulator
I6J71_RS29755	COG4166	transmembrane transport
I6J71_RS29765	COG0444	Belongs to the ABC transporter superfamily
I6J71_RS29775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J71_RS29795	COG2188	Transcriptional regulator
I6J71_RS29800	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_RS29820	COG0297	glycogen (starch) synthase activity
I6J71_RS29830	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_RS29875	COG2271	Major facilitator Superfamily
I6J71_RS29880	COG1414	Transcriptional regulator
I6J71_RS29885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS29890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_RS29895	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS29950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J71_RS29980	COG0784	Response regulator, receiver
I6J71_RS29985	COG4251	negative regulation of phosphorylation
I6J71_RS29990	COG0745	RESPONSE REGULATOR receiver
I6J71_RS30000	COG1410	methionine synthase
I6J71_RS30000	COG0646	methionine synthase
I6J71_RS30020	COG1846	Transcriptional regulator
I6J71_RS30035	COG2318	DinB family
I6J71_RS30050	COG3964	amidohydrolase
I6J71_RS30060	COG1024	Enoyl-CoA hydratase
I6J71_RS30070	COG0765	amino acid transport
I6J71_RS30085	COG3622	Belongs to the hyi family
I6J71_RS30090	COG2084	Dehydrogenase
I6J71_RS30100	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS30115	COG0656	L-ascorbic acid biosynthetic process
I6J71_RS30160	COG0439	Biotin carboxylase
I6J71_RS30165	COG1454	alcohol dehydrogenase
I6J71_RS30205	COG2815	serine threonine protein kinase
I6J71_RS30205	COG0515	serine threonine protein kinase
I6J71_RS30215	COG1715	Restriction endonuclease
I6J71_RS30230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J71_RS30235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6J71_RS30260	COG1793	dna ligase
I6J71_RS30265	COG1414	Transcriptional regulator
I6J71_RS30290	COG2271	Major facilitator Superfamily
I6J71_RS30310	COG0066	3-isopropylmalate dehydratase activity
I6J71_RS30315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J71_RS30320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J71_RS30325	COG0066	3-isopropylmalate dehydratase activity
I6J71_RS30340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS30345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS30375	COG2826	transposase and inactivated derivatives, IS30 family
I6J71_RS30385	COG0477	Major facilitator Superfamily
I6J71_RS30395	COG1309	transcriptional regulator
I6J71_RS30430	COG1846	Transcriptional regulator
I6J71_RS30440	COG0564	pseudouridine synthase activity
I6J71_RS30455	COG1063	alcohol dehydrogenase
I6J71_RS30465	COG2124	cytochrome p450
I6J71_RS30490	COG1609	Transcriptional regulator
I6J71_RS30500	COG1940	carbohydrate kinase activity
I6J71_RS30505	COG3250	beta-galactosidase activity
I6J71_RS30510	COG0531	amino acid
I6J71_RS30520	COG0484	heat shock protein binding
I6J71_RS30525	COG1280	lysine exporter protein (LysE YggA)
I6J71_RS30545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_RS30550	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS30560	COG2197	response regulator
I6J71_RS30580	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS30585	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS30590	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS30595	COG0596	Alpha beta hydrolase
I6J71_RS30600	COG0154	amidase activity
I6J71_RS30615	COG1309	transcriptional regulator
I6J71_RS30625	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS30635	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS30650	COG3573	Dehydrogenase
I6J71_RS30655	COG0129	dihydroxy-acid dehydratase activity
I6J71_RS30660	COG0477	Major facilitator Superfamily
I6J71_RS30665	COG0583	DNA-binding transcription factor activity
I6J71_RS30670	COG1309	transcriptional regulator
I6J71_RS30685	COG3706	GGDEF domain
I6J71_RS30700	COG3469	chitinase activity
I6J71_RS30735	COG0583	DNA-binding transcription factor activity
I6J71_RS30750	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS30765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J71_RS30770	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS30785	COG1024	Enoyl-CoA hydratase
I6J71_RS30790	COG4689	acetoacetate decarboxylase
I6J71_RS30795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J71_RS30795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J71_RS30800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J71_RS30830	COG1316	TRANSCRIPTIONal
I6J71_RS30835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J71_RS30845	COG4821	SIS domain
I6J71_RS30850	COG1132	(ABC) transporter
I6J71_RS30865	COG0488	(ABC) transporter
I6J71_RS30880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6J71_RS30890	COG2200	EAL domain
I6J71_RS30890	COG2199	diguanylate cyclase activity
I6J71_RS30905	COG5640	endopeptidase activity
I6J71_RS30920	COG1742	UPF0060 membrane protein
I6J71_RS30930	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J71_RS30945	COG0396	ATPase activity
I6J71_RS31010	COG1278	Cold shock
I6J71_RS31030	COG0109	protoheme IX farnesyltransferase activity
I6J71_RS31040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J71_RS31045	COG0166	Belongs to the GPI family
I6J71_RS31060	COG0363	glucosamine-6-phosphate deaminase activity
I6J71_RS31065	COG4585	Histidine kinase
I6J71_RS31075	COG0277	FAD linked oxidase domain protein
I6J71_RS31095	COG0149	triose-phosphate isomerase activity
I6J71_RS31100	COG0126	phosphoglycerate kinase activity
I6J71_RS31105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J71_RS31115	COG1280	lysine exporter protein (LysE YggA)
I6J71_RS31160	COG1481	regulation of sporulation
I6J71_RS31170	COG1660	Displays ATPase and GTPase activities
I6J71_RS31175	COG0322	excinuclease ABC activity
I6J71_RS31195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J71_RS31200	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS31200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS31230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J71_RS31235	COG1610	YqeY-like protein
I6J71_RS31250	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J71_RS31255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J71_RS31265	COG1758	RNA polymerase activity
I6J71_RS31270	COG0194	GDP metabolic process
I6J71_RS31280	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J71_RS31290	COG0505	Belongs to the CarA family
I6J71_RS31305	COG0540	Belongs to the ATCase OTCase family
I6J71_RS31310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J71_RS31325	COG3547	Transposase (IS116 IS110 IS902 family)
I6J71_RS31335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J71_RS31340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J71_RS31345	COG0006	proline dipeptidase activity
I6J71_RS31365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J71_RS31370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J71_RS31375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J71_RS31380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J71_RS31415	COG1263	PTS System
I6J71_RS31415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J71_RS31415	COG2190	(PTS) system
I6J71_RS31420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J71_RS31425	COG2188	Transcriptional regulator
I6J71_RS31430	COG1263	PTS System
I6J71_RS31435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J71_RS31455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J71_RS31460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J71_RS31475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J71_RS31490	COG2084	Dehydrogenase
I6J71_RS31495	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6J71_RS31515	COG2124	cytochrome p450
I6J71_RS31535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J71_RS31565	COG0174	glutamine synthetase
I6J71_RS31595	COG2326	polyphosphate kinase activity
I6J71_RS31605	COG0640	Transcriptional regulator
I6J71_RS31610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J71_RS31630	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J71_RS31640	COG1595	DNA-templated transcription, initiation
I6J71_RS31660	COG1793	dna ligase
I6J71_RS31675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J71_RS31680	COG0506	proline dehydrogenase activity
I6J71_RS31685	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS31690	COG2508	Transcriptional regulator
I6J71_RS31690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J71_RS31705	COG0539	negative regulation of cytoplasmic translation
I6J71_RS31710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS31730	COG0515	serine threonine protein kinase
I6J71_RS31730	COG2815	serine threonine protein kinase
I6J71_RS31745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J71_RS31755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS31760	COG3253	May function as heme-dependent peroxidase
I6J71_RS31770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J71_RS31780	COG2197	response regulator
I6J71_RS31800	COG0183	Belongs to the thiolase family
I6J71_RS31805	COG1024	Enoyl-CoA hydratase
I6J71_RS31805	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_RS31820	COG2205	protein histidine kinase activity
I6J71_RS31825	COG0745	RESPONSE REGULATOR receiver
I6J71_RS31860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J71_RS31865	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS31895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J71_RS31900	COG0531	amino acid
I6J71_RS31905	COG0569	domain protein
I6J71_RS31935	COG0756	dUTP diphosphatase activity
I6J71_RS31955	COG0483	inositol monophosphate 1-phosphatase activity
I6J71_RS31960	COG1940	carbohydrate kinase activity
I6J71_RS32025	COG2197	response regulator
I6J71_RS32030	COG0531	amino acid
I6J71_RS32040	COG0174	glutamine synthetase
I6J71_RS32060	COG4214	carbohydrate transport
I6J71_RS32070	COG4213	ABC transporter substrate-binding protein
I6J71_RS32105	COG2313	pseudouridylate synthase activity
I6J71_RS32125	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J71_RS32130	COG1490	D-aminoacyl-tRNA deacylase activity
I6J71_RS32140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J71_RS32140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J71_RS32170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J71_RS32175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J71_RS32205	COG1295	ribonuclease BN
I6J71_RS32215	COG2124	cytochrome p450
I6J71_RS32260	COG0596	Alpha beta hydrolase
I6J71_RS32285	COG4585	Histidine kinase
I6J71_RS32290	COG2197	response regulator
I6J71_RS32305	COG1228	amidohydrolase
I6J71_RS32310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS32320	COG1473	amidohydrolase
I6J71_RS32395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J71_RS32420	COG2030	dehydratase
I6J71_RS32425	COG0196	riboflavin kinase activity
I6J71_RS32465	COG0657	acetylesterase activity
I6J71_RS32475	COG0302	gtp cyclohydrolase
I6J71_RS32490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J71_RS32500	COG1309	transcriptional regulator
I6J71_RS32505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS32515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS32525	COG1703	isobutyryl-CoA mutase activity
I6J71_RS32525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_RS32525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6J71_RS32545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J71_RS32560	COG2018	Roadblock/LC7 domain
I6J71_RS32575	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS32580	COG1309	transcriptional regulator
I6J71_RS32595	COG1566	PFAM secretion protein HlyD family protein
I6J71_RS32620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS32625	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS32650	COG1672	PFAM Archaeal ATPase
I6J71_RS32650	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_RS32670	COG1946	Acyl-CoA thioesterase
I6J71_RS32710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J71_RS32745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J71_RS32755	COG1940	carbohydrate kinase activity
I6J71_RS32765	COG0003	Pfam Anion-transporting ATPase
I6J71_RS32800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_RS32815	COG2255	four-way junction helicase activity
I6J71_RS32835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J71_RS32860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J71_RS32865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J71_RS32885	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6J71_RS32900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J71_RS32905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J71_RS32920	COG4585	Histidine kinase
I6J71_RS32925	COG2197	response regulator
I6J71_RS32935	COG2936	dipeptidyl-peptidase activity
I6J71_RS32945	COG0516	GMP reductase activity
I6J71_RS32945	COG0517	IMP dehydrogenase activity
I6J71_RS32970	COG1505	serine-type exopeptidase activity
I6J71_RS32980	COG3226	Transcriptional regulator
I6J71_RS32990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J71_RS32995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J71_RS33005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J71_RS33015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J71_RS33030	COG0525	valine-tRNA ligase activity
I6J71_RS33035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6J71_RS33040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J71_RS33045	COG1196	nuclear chromosome segregation
I6J71_RS33055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J71_RS33075	COG1126	abc transporter atp-binding protein
I6J71_RS33080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_RS33085	COG0765	amino acid transport
I6J71_RS33090	COG0765	amino acid transport
I6J71_RS33100	COG1228	amidohydrolase
I6J71_RS33115	COG1053	succinate dehydrogenase
I6J71_RS33135	COG0800	Aldolase
I6J71_RS33140	COG2137	regulation of response to DNA damage stimulus
I6J71_RS33145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J71_RS33155	COG0443	Heat shock 70 kDa protein
I6J71_RS33160	COG2271	Major facilitator Superfamily
I6J71_RS33165	COG1201	RNA secondary structure unwinding
I6J71_RS33170	COG0242	peptide deformylase activity
I6J71_RS33190	COG1131	(ABC) transporter
I6J71_RS33255	COG0142	geranyltranstransferase activity
I6J71_RS33290	COG2268	Band 7 protein
I6J71_RS33305	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6J71_RS33315	COG0067	glutamate synthase
I6J71_RS33315	COG0070	glutamate synthase
I6J71_RS33315	COG0069	glutamate synthase activity
I6J71_RS33340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J71_RS33345	COG1473	amidohydrolase
I6J71_RS33360	COG0174	glutamine synthetase
I6J71_RS33365	COG0159	tryptophan synthase activity
I6J71_RS33370	COG0133	tryptophan synthase activity
I6J71_RS33375	COG0134	indole-3-glycerol-phosphate synthase activity
I6J71_RS33385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J71_RS33415	COG0107	imidazoleglycerol-phosphate synthase activity
I6J71_RS33445	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6J71_RS33450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J71_RS33460	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS33465	COG3958	Transketolase
I6J71_RS33470	COG3959	Transketolase, thiamine diphosphate binding domain
I6J71_RS33480	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6J71_RS33485	COG1309	transcriptional regulator
I6J71_RS33490	COG2409	Drug exporters of the RND superfamily
I6J71_RS33500	COG1234	tRNA 3'-trailer cleavage
I6J71_RS33510	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J71_RS33515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J71_RS33520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J71_RS33545	COG0456	acetyltransferase
I6J71_RS33545	COG0454	-acetyltransferase
I6J71_RS33550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_RS33560	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS33585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J71_RS33590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J71_RS33600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J71_RS33620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6J71_RS33635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6J71_RS33640	COG2124	cytochrome p450
I6J71_RS33650	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS33680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J71_RS33690	COG2010	Cytochrome c
I6J71_RS33695	COG1845	cytochrome c oxidase, subunit III
I6J71_RS33710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J71_RS33730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J71_RS33745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J71_RS33765	COG0667	Aldo Keto reductase
I6J71_RS33780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J71_RS33815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_RS33820	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_RS33835	COG1090	epimerase
I6J71_RS33845	COG0321	lipoyl(octanoyl) transferase activity
I6J71_RS33870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J71_RS33885	COG1376	ErfK ybiS ycfS ynhG family protein
I6J71_RS33915	COG0587	DNA-directed DNA polymerase activity
I6J71_RS33950	COG1104	cysteine desulfurase activity
I6J71_RS33955	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS33990	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6J71_RS34000	COG1620	l-lactate permease
I6J71_RS34005	COG3201	nicotinamide mononucleotide transporter
I6J71_RS34015	COG1668	transmembrane transport
I6J71_RS34020	COG4152	abc transporter atp-binding protein
I6J71_RS34035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J71_RS34065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J71_RS34085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6J71_RS34095	COG1309	transcriptional regulator
I6J71_RS34120	COG2197	response regulator
I6J71_RS34135	COG0546	phosphoglycolate phosphatase activity
I6J71_RS34150	COG0442	prolyl-tRNA aminoacylation
I6J71_RS34170	COG3022	response to hydroperoxide
I6J71_RS34175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J71_RS34190	COG0513	Belongs to the DEAD box helicase family
I6J71_RS34225	COG2807	transmembrane transport
I6J71_RS34230	COG2186	Transcriptional regulator
I6J71_RS34255	COG0456	acetyltransferase
I6J71_RS34255	COG0454	-acetyltransferase
I6J71_RS34280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J71_RS34285	COG0750	zinc metalloprotease
I6J71_RS34290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J71_RS34300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J71_RS34310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6J71_RS34310	COG2755	lipolytic protein G-D-S-L family
I6J71_RS34315	COG2814	Major facilitator Superfamily
I6J71_RS34320	COG0277	FAD linked oxidase domain protein
I6J71_RS34365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J71_RS34370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J71_RS34375	COG1695	Transcriptional regulator
I6J71_RS34380	COG2226	methyltransferase
I6J71_RS34390	COG0477	Major facilitator Superfamily
I6J71_RS34400	COG0233	cytoplasmic translational termination
I6J71_RS34405	COG0528	UMP kinase activity
I6J71_RS34410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J71_RS34415	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J71_RS34425	COG1191	sigma factor activity
I6J71_RS34445	COG0792	nuclease activity
I6J71_RS34455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J71_RS34460	COG0681	Belongs to the peptidase S26 family
I6J71_RS34465	COG0335	large ribosomal subunit rRNA binding
I6J71_RS34470	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J71_RS34475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J71_RS34485	COG0228	four-way junction DNA binding
I6J71_RS34505	COG1132	(ABC) transporter
I6J71_RS34525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6J71_RS34540	COG2226	methyltransferase
I6J71_RS34555	COG2873	o-acetylhomoserine
I6J71_RS34560	COG1832	CoA-binding protein
I6J71_RS34590	COG4266	Belongs to the allantoicase family
I6J71_RS34595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J71_RS34620	COG2233	PERMEase
I6J71_RS34625	COG1309	transcriptional regulator
I6J71_RS34630	COG0281	malic enzyme
I6J71_RS34645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J71_RS34665	COG3835	regulator
I6J71_RS34670	COG0326	Molecular chaperone. Has ATPase activity
I6J71_RS34680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J71_RS34685	COG1414	Transcriptional regulator
I6J71_RS34690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J71_RS34710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6J71_RS34715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS34730	COG1254	Belongs to the acylphosphatase family
I6J71_RS34750	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6J71_RS34755	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J71_RS34760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J71_RS34770	COG0367	asparagine synthase
I6J71_RS34790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J71_RS34795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_RS34805	COG0667	Aldo Keto reductase
I6J71_RS34810	COG0673	inositol 2-dehydrogenase activity
I6J71_RS34820	COG1082	Xylose isomerase domain protein TIM barrel
I6J71_RS34840	COG3718	enzyme involved in inositol metabolism
I6J71_RS34845	COG3962	Belongs to the TPP enzyme family
I6J71_RS34855	COG0492	ferredoxin-NADP+ reductase activity
I6J71_RS34905	COG0746	molybdenum cofactor guanylyltransferase activity
I6J71_RS34910	COG1414	Transcriptional regulator
I6J71_RS34915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J71_RS34920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_RS34925	COG3485	protocatechuate 3,4-dioxygenase
I6J71_RS34930	COG3485	protocatechuate 3,4-dioxygenase
I6J71_RS34940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J71_RS34945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J71_RS34955	COG0395	ABC-type sugar transport system, permease component
I6J71_RS34960	COG1175	transmembrane transport
I6J71_RS34985	COG1929	Belongs to the glycerate kinase type-1 family
I6J71_RS35030	COG2186	Transcriptional regulator
I6J71_RS35035	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS35040	COG1129	ABC transporter
I6J71_RS35045	COG1879	ABC-type sugar transport system periplasmic component
I6J71_RS35055	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS35060	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_RS35090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_RS35095	COG1120	ATPase activity
I6J71_RS35100	COG4122	O-methyltransferase activity
I6J71_RS35110	COG2186	Transcriptional regulator
I6J71_RS35125	COG1760	l-serine dehydratase
I6J71_RS35130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J71_RS35135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J71_RS35140	COG0509	glycine decarboxylation via glycine cleavage system
I6J71_RS35145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J71_RS35150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J71_RS35150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J71_RS35165	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS35170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J71_RS35210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J71_RS35215	COG0571	ribonuclease III activity
I6J71_RS35220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J71_RS35240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J71_RS35245	COG0742	ribosomal rna small subunit methyltransferase
I6J71_RS35250	COG3973	AAA domain
I6J71_RS35255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS35280	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6J71_RS35320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J71_RS35330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J71_RS35335	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J71_RS35370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_RS35410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J71_RS35415	COG0252	asparaginase activity
I6J71_RS35425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J71_RS35435	COG1920	GTP binding
I6J71_RS35450	COG0776	regulation of translation
I6J71_RS35455	COG0066	3-isopropylmalate dehydratase activity
I6J71_RS35460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J71_RS35475	COG0776	regulation of translation
I6J71_RS35515	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J71_RS35520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_RS35525	COG0473	3-isopropylmalate dehydrogenase activity
I6J71_RS35530	COG1404	Belongs to the peptidase S8 family
I6J71_RS35555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J71_RS35560	COG0440	acetolactate synthase activity
I6J71_RS35575	COG0129	dihydroxy-acid dehydratase activity
I6J71_RS35580	COG2259	Doxx family
I6J71_RS35585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J71_RS35605	COG0154	amidase activity
I6J71_RS35610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J71_RS35625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J71_RS35645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J71_RS35655	COG0482	sulfurtransferase activity
I6J71_RS35670	COG2197	response regulator
I6J71_RS35690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J71_RS35700	COG1307	EDD domain protein, DegV family
I6J71_RS35710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6J71_RS35720	COG0386	Belongs to the glutathione peroxidase family
I6J71_RS35725	COG3250	beta-galactosidase activity
I6J71_RS35750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J71_RS35765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J71_RS35800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS35805	COG0531	amino acid
I6J71_RS35810	COG0110	maltose O-acetyltransferase activity
I6J71_RS35820	COG0791	NLP P60 protein
I6J71_RS35820	COG3883	PFAM NLP P60 protein
I6J71_RS35845	COG4552	Acetyltransferase involved in intracellular survival and related
I6J71_RS35855	COG1309	transcriptional regulator
I6J71_RS35870	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS35900	COG0492	ferredoxin-NADP+ reductase activity
I6J71_RS35945	COG2226	methyltransferase
I6J71_RS35950	COG1024	Enoyl-CoA hydratase
I6J71_RS35955	COG1119	ATPase activity
I6J71_RS35980	COG0058	SHG alpha-glucan phosphorylase activity
I6J71_RS36005	COG1846	Transcriptional regulator
I6J71_RS36015	COG3537	Alpha-1,2-mannosidase
I6J71_RS36020	COG3537	Alpha-1,2-mannosidase
I6J71_RS36025	COG1609	Transcriptional regulator
I6J71_RS36050	COG3275	phosphorelay sensor kinase activity
I6J71_RS36055	COG3279	Response regulator of the LytR AlgR family
I6J71_RS36065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS36075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS36095	COG0183	Belongs to the thiolase family
I6J71_RS36100	COG0346	lactoylglutathione lyase activity
I6J71_RS36125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_RS36130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_RS36135	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J71_RS36140	COG3396	Phenylacetate-CoA oxygenase
I6J71_RS36145	COG3460	Phenylacetate-CoA oxygenase
I6J71_RS36150	COG3396	Phenylacetate-CoA oxygenase
I6J71_RS36155	COG2030	dehydratase
I6J71_RS36155	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS36170	COG1309	transcriptional regulator
I6J71_RS36195	COG2072	flavoprotein involved in K transport
I6J71_RS36210	COG2183	response to ionizing radiation
I6J71_RS36220	COG0513	Belongs to the DEAD box helicase family
I6J71_RS36230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J71_RS36245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J71_RS36250	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS36255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J71_RS36285	COG3540	Alkaline phosphatase
I6J71_RS36295	COG3629	intracellular signal transduction
I6J71_RS36295	COG3903	Transcriptional regulator
I6J71_RS36320	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J71_RS36330	COG1879	ABC-type sugar transport system periplasmic component
I6J71_RS36350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J71_RS36355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J71_RS36355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J71_RS36375	COG1129	ABC transporter
I6J71_RS36380	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS36385	COG2186	Transcriptional regulator
I6J71_RS36415	COG1131	(ABC) transporter
I6J71_RS36420	COG0596	Alpha beta hydrolase
I6J71_RS36440	COG1126	abc transporter atp-binding protein
I6J71_RS36445	COG0765	amino acid transport
I6J71_RS36450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_RS36520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J71_RS36590	COG1595	DNA-templated transcription, initiation
I6J71_RS36625	COG2801	Transposase and inactivated derivatives
I6J71_RS36670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J71_RS36685	COG3119	arylsulfatase activity
I6J71_RS36695	COG2814	Major facilitator Superfamily
I6J71_RS36710	COG1609	Transcriptional regulator
I6J71_RS36715	COG2814	Major facilitator Superfamily
I6J71_RS36720	COG3119	arylsulfatase activity
I6J71_RS36730	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_RS36775	COG0494	nUDIX hydrolase
I6J71_RS36785	COG0704	Plays a role in the regulation of phosphate uptake
I6J71_RS36800	COG4941	Belongs to the sigma-70 factor family
I6J71_RS36820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS36830	COG1063	alcohol dehydrogenase
I6J71_RS36865	COG3387	PFAM Glycoside hydrolase 15-related
I6J71_RS36870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J71_RS36875	COG0129	dihydroxy-acid dehydratase activity
I6J71_RS36880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J71_RS36890	COG2234	aminopeptidase activity
I6J71_RS36930	COG1073	alpha beta
I6J71_RS36935	COG1414	Transcriptional regulator
I6J71_RS36940	COG0477	Major facilitator Superfamily
I6J71_RS36945	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS36960	COG0154	amidase activity
I6J71_RS37010	COG2986	histidine ammonia-lyase
I6J71_RS37025	COG1595	DNA-templated transcription, initiation
I6J71_RS37030	COG2814	Major facilitator Superfamily
I6J71_RS37060	COG0789	Transcriptional regulator
I6J71_RS37065	COG2226	methyltransferase
I6J71_RS37085	COG0488	(ABC) transporter
I6J71_RS37090	COG3511	phospholipase C
I6J71_RS37115	COG2226	methyltransferase
I6J71_RS37130	COG2072	flavoprotein involved in K transport
I6J71_RS37135	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS37140	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS37145	COG1309	transcriptional regulator
I6J71_RS37165	COG2205	protein histidine kinase activity
I6J71_RS37175	COG0726	polysaccharide deacetylase
I6J71_RS37180	COG2197	response regulator
I6J71_RS37190	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J71_RS37195	COG3858	chitin binding
I6J71_RS37195	COG1388	LysM domain
I6J71_RS37235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J71_RS37245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J71_RS37255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS37265	COG1396	sequence-specific DNA binding
I6J71_RS37330	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS37335	COG0435	Glutathione S-transferase
I6J71_RS37345	COG2353	YceI-like domain
I6J71_RS37360	COG1309	transcriptional regulator
I6J71_RS37375	COG2814	Major facilitator Superfamily
I6J71_RS37395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J71_RS37415	COG2815	serine threonine protein kinase
I6J71_RS37415	COG0515	serine threonine protein kinase
I6J71_RS37425	COG3706	GGDEF domain
I6J71_RS37430	COG0393	Putative heavy-metal-binding
I6J71_RS37450	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS37570	COG4221	oxidoreductase activity
I6J71_RS37600	COG3458	cephalosporin-C deacetylase activity
I6J71_RS37610	COG0395	ABC-type sugar transport system, permease component
I6J71_RS37620	COG3345	alpha-galactosidase
I6J71_RS37640	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J71_RS37650	COG1309	transcriptional regulator
I6J71_RS37670	COG3795	YCII-related domain
I6J71_RS37675	COG4941	Belongs to the sigma-70 factor family
I6J71_RS37685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS37690	COG0187	DNA topoisomerase II activity
I6J71_RS37695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J71_RS37695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J71_RS37705	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J71_RS37720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_RS37725	COG1643	Atp-dependent helicase
I6J71_RS37730	COG1131	(ABC) transporter
I6J71_RS37750	COG2197	response regulator
I6J71_RS37755	COG4585	Histidine kinase
I6J71_RS37790	COG1228	amidohydrolase
I6J71_RS37805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J71_RS37810	COG2986	histidine ammonia-lyase
I6J71_RS37820	COG0405	Gamma-glutamyltransferase
I6J71_RS37830	COG0583	DNA-binding transcription factor activity
I6J71_RS37845	COG4585	Histidine kinase
I6J71_RS37850	COG2197	response regulator
I6J71_RS37870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J71_RS37875	COG2177	Part of the ABC transporter FtsEX involved in
I6J71_RS37880	COG2884	Cell division ATP-binding protein ftsE
I6J71_RS37885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J71_RS37920	COG1615	UPF0182 protein
I6J71_RS37930	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J71_RS38015	COG2226	methyltransferase
I6J71_RS38025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J71_RS38045	COG1522	sequence-specific DNA binding
I6J71_RS38065	COG0174	glutamine synthetase
I6J71_RS38085	COG0653	protein targeting
I6J71_RS38090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS38090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J71_RS38095	COG2169	Transcriptional regulator
I6J71_RS38095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J71_RS38105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6J71_RS38105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J71_RS38110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6J71_RS38120	COG1968	undecaprenyl-diphosphatase activity
I6J71_RS38125	COG0596	Alpha beta hydrolase
I6J71_RS38130	COG1309	transcriptional regulator
I6J71_RS38135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS38140	COG1177	transmembrane transport
I6J71_RS38145	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J71_RS38150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6J71_RS38155	COG3842	ATPase activity
I6J71_RS38160	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS38185	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS38195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J71_RS38265	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6J71_RS38285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J71_RS38305	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6J71_RS38315	COG3265	gluconokinase activity
I6J71_RS38325	COG0667	Aldo Keto reductase
I6J71_RS38330	COG2207	Transcriptional regulator
I6J71_RS38335	COG0640	Transcriptional regulator
I6J71_RS38350	COG1486	melibiose metabolic process
I6J71_RS38355	COG0395	ABC-type sugar transport system, permease component
I6J71_RS38360	COG1175	transmembrane transport
I6J71_RS38380	COG0612	Peptidase, M16
I6J71_RS38415	COG0714	Associated with various cellular activities
I6J71_RS38475	COG2378	regulation of single-species biofilm formation
I6J71_RS38505	COG2146	nitrite reductase [NAD(P)H] activity
I6J71_RS38505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J71_RS38510	COG2223	nitrite transmembrane transporter activity
I6J71_RS38515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J71_RS38520	COG0243	molybdopterin cofactor binding
I6J71_RS38540	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6J71_RS38555	COG2267	carboxylic ester hydrolase activity
I6J71_RS38585	COG0513	Belongs to the DEAD box helicase family
I6J71_RS38605	COG2095	MarC family integral membrane protein
I6J71_RS38610	COG0613	PHP domain protein
I6J71_RS38635	COG0598	Magnesium transport protein CorA
I6J71_RS38660	COG1309	transcriptional regulator
I6J71_RS38735	COG0330	HflC and HflK could
I6J71_RS38745	COG2239	Acts as a magnesium transporter
I6J71_RS38765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J71_RS38770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J71_RS38790	COG2814	Major facilitator Superfamily
I6J71_RS38795	COG0583	DNA-binding transcription factor activity
I6J71_RS38800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J71_RS38810	COG1024	Enoyl-CoA hydratase
I6J71_RS38815	COG2818	Glycosylase
I6J71_RS38840	COG1271	oxidase subunit
I6J71_RS38845	COG1294	oxidase, subunit
I6J71_RS38850	COG4988	ABC transporter
I6J71_RS38855	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J71_RS38860	COG0463	Glycosyl transferase, family 2
I6J71_RS38875	COG1611	Belongs to the LOG family
I6J71_RS38880	COG2353	YceI-like domain
I6J71_RS38935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J71_RS38940	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6J71_RS38940	COG0778	Nitroreductase
I6J71_RS38955	COG1725	Transcriptional regulator
I6J71_RS39000	COG0297	glycogen (starch) synthase activity
I6J71_RS39030	COG1316	TRANSCRIPTIONal
I6J71_RS39035	COG1316	TRANSCRIPTIONal
I6J71_RS39075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J71_RS39080	COG2267	carboxylic ester hydrolase activity
I6J71_RS39090	COG0667	Aldo Keto reductase
I6J71_RS39120	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS39125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J71_RS39185	COG2205	protein histidine kinase activity
I6J71_RS39195	COG0483	inositol monophosphate 1-phosphatase activity
I6J71_RS39205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS39240	COG1388	LysM domain
I6J71_RS39240	COG3103	Sh3 type 3 domain protein
I6J71_RS39240	COG0791	NLP P60 protein
I6J71_RS39255	COG3511	phospholipase C
I6J71_RS39290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J71_RS39305	COG1309	transcriptional regulator
I6J71_RS39330	COG0424	maF-like protein
I6J71_RS39335	COG1301	dicarboxylic acid transport
I6J71_RS39350	COG4770	biotin carboxylase activity
I6J71_RS39380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J71_RS39390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J71_RS39430	COG1473	amidohydrolase
I6J71_RS39430	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6J71_RS39455	COG0515	serine threonine protein kinase
I6J71_RS39500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J71_RS39530	COG1309	transcriptional regulator
I6J71_RS39540	COG0596	Alpha beta hydrolase
I6J71_RS39565	COG4191	Histidine kinase
I6J71_RS39570	COG0745	RESPONSE REGULATOR receiver
I6J71_RS39575	COG0475	glutathione-regulated potassium exporter activity
I6J71_RS39595	COG0667	Aldo Keto reductase
I6J71_RS39600	COG0667	Aldo Keto reductase
I6J71_RS39605	COG0789	Transcriptional regulator
I6J71_RS39675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J71_RS39680	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS39685	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS39715	COG2124	cytochrome p450
I6J71_RS39740	COG3842	ATPase activity
I6J71_RS39745	COG0395	ABC-type sugar transport system, permease component
I6J71_RS39750	COG1175	transmembrane transport
I6J71_RS39760	COG1063	alcohol dehydrogenase
I6J71_RS39770	COG1280	lysine exporter protein (LysE YggA)
I6J71_RS39785	COG2271	Major facilitator Superfamily
I6J71_RS39790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J71_RS39810	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J71_RS39820	COG3845	ABC transporter
I6J71_RS39825	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J71_RS39835	COG2009	succinate dehydrogenase
I6J71_RS39850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J71_RS39875	COG1295	ribonuclease BN
I6J71_RS39895	COG0180	Tryptophanyl-tRNA synthetase
I6J71_RS39965	COG2814	Major facilitator Superfamily
I6J71_RS39970	COG0640	Transcriptional regulator
I6J71_RS39975	COG2814	Major facilitator Superfamily
I6J71_RS39985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J71_RS40015	COG0587	DNA-directed DNA polymerase activity
I6J71_RS40030	COG0596	Alpha beta hydrolase
I6J71_RS40035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J71_RS40040	COG0138	bifunctional purine biosynthesis protein purh
I6J71_RS40065	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J71_RS40110	COG0515	serine threonine protein kinase
I6J71_RS40125	COG0697	spore germination
I6J71_RS40150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J71_RS40150	COG0519	Catalyzes the synthesis of GMP from XMP
I6J71_RS40170	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS40175	COG0277	FAD linked oxidase domain protein
I6J71_RS40195	COG0516	GMP reductase activity
I6J71_RS40250	COG1309	transcriptional regulator
I6J71_RS40255	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS40260	COG0459	protein refolding
I6J71_RS40265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J71_RS40270	COG0640	Transcriptional regulator
I6J71_RS40290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J71_RS40295	COG0456	acetyltransferase
I6J71_RS40305	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS40310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J71_RS40310	COG0825	malonyl-CoA metabolic process
I6J71_RS40315	COG0802	atpase or kinase
I6J71_RS40325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J71_RS40330	COG3842	ATPase activity
I6J71_RS40335	COG1070	Carbohydrate kinase
I6J71_RS40340	COG1349	DNA-binding transcription factor activity
I6J71_RS40345	COG2226	methyltransferase
I6J71_RS40360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J71_RS40400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J71_RS40410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J71_RS40440	COG0443	Heat shock 70 kDa protein
I6J71_RS40445	COG1674	ftsk spoiiie
I6J71_RS40455	COG1404	Belongs to the peptidase S8 family
I6J71_RS40490	COG0203	ribosomal protein L17
I6J71_RS40495	COG0202	RNA polymerase activity
I6J71_RS40500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J71_RS40505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J71_RS40515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J71_RS40520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J71_RS40525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J71_RS40535	COG0563	adenylate kinase activity
I6J71_RS40545	COG0200	Binds to the 23S rRNA
I6J71_RS40550	COG1841	ribosomal large subunit assembly
I6J71_RS40555	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J71_RS40560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J71_RS40565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J71_RS40570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J71_RS40580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J71_RS40585	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J71_RS40590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J71_RS40595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6J71_RS40600	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J71_RS40605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J71_RS40610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J71_RS40615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J71_RS40620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J71_RS40625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J71_RS40630	COG0089	rRNA binding
I6J71_RS40635	COG0088	Forms part of the polypeptide exit tunnel
I6J71_RS40640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J71_RS40645	COG0051	transcription antitermination factor activity, RNA binding
I6J71_RS40655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J71_RS40660	COG0049	tRNA binding
I6J71_RS40665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J71_RS40700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J71_RS40710	COG1605	Chorismate mutase
I6J71_RS40730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J71_RS40755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J71_RS40790	COG0081	regulation of translation
I6J71_RS40830	COG2030	dehydratase
I6J71_RS40835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J71_RS40870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J71_RS40885	COG1666	GTP binding
I6J71_RS40905	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J71_RS40920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS40930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J71_RS40945	COG4310	Domain of unknown function (DUF2172)
I6J71_RS40955	COG1216	Glycosyl transferase, family 2
I6J71_RS40955	COG0463	Glycosyl transferase, family 2
I6J71_RS40965	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6J71_RS40970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J71_RS41030	COG0367	asparagine synthase
I6J71_RS41050	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J71_RS41065	COG1834	amidinotransferase
I6J71_RS41070	COG1522	sequence-specific DNA binding
I6J71_RS41075	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6J71_RS41075	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6J71_RS41080	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6J71_RS41090	COG0142	geranyltranstransferase activity
I6J71_RS41110	COG1007	ATP synthesis coupled electron transport
I6J71_RS41120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J71_RS41125	COG0713	ATP synthesis coupled electron transport
I6J71_RS41130	COG0839	Belongs to the complex I subunit 6 family
I6J71_RS41135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J71_RS41140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6J71_RS41145	COG1034	ATP synthesis coupled electron transport
I6J71_RS41150	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J71_RS41160	COG0649	NAD binding
I6J71_RS41165	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J71_RS41170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J71_RS41185	COG2226	methyltransferase
I6J71_RS41190	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS41220	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J71_RS41240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J71_RS41250	COG1522	sequence-specific DNA binding
I6J71_RS41270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J71_RS41280	COG0785	Cytochrome C biogenesis protein
I6J71_RS41290	COG0406	alpha-ribazole phosphatase activity
I6J71_RS41295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J71_RS41325	COG0577	efflux transmembrane transporter activity
I6J71_RS41325	COG1136	(ABC) transporter
I6J71_RS41330	COG0577	efflux transmembrane transporter activity
I6J71_RS41330	COG1136	(ABC) transporter
I6J71_RS41335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J71_RS41375	COG1587	Uroporphyrinogen-III synthase
I6J71_RS41375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J71_RS41380	COG0181	hydroxymethylbilane synthase activity
I6J71_RS41385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6J71_RS41390	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J71_RS41415	COG1595	DNA-templated transcription, initiation
I6J71_RS41450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J71_RS41485	COG5002	protein histidine kinase activity
I6J71_RS41490	COG0667	Aldo Keto reductase
I6J71_RS41505	COG0588	phosphoglycerate mutase activity
I6J71_RS41520	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS41535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J71_RS41565	COG1064	alcohol dehydrogenase
I6J71_RS41585	COG2130	NADP-dependent
I6J71_RS41600	COG1174	glycine betaine transport
I6J71_RS41605	COG1174	glycine betaine transport
I6J71_RS41620	COG2986	histidine ammonia-lyase
I6J71_RS41675	COG2733	membrane
I6J71_RS41695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J71_RS41780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS41785	COG0667	Aldo Keto reductase
I6J71_RS41840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J71_RS41885	COG2124	cytochrome p450
I6J71_RS41890	COG1414	Transcriptional regulator
I6J71_RS41895	COG0789	Transcriptional regulator
I6J71_RS41905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J71_RS41910	COG2233	PERMEase
I6J71_RS41945	COG2814	Major facilitator Superfamily
I6J71_RS41950	COG0477	Major facilitator Superfamily
I6J71_RS42005	COG1278	Cold shock
I6J71_RS42030	COG0515	serine threonine protein kinase
I6J71_RS42035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J71_RS42065	COG0022	dehydrogenase e1 component
I6J71_RS42070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J71_RS42075	COG3199	ATP-NAD kinase
I6J71_RS42095	COG0028	Belongs to the TPP enzyme family
I6J71_RS42115	COG1335	isochorismatase
I6J71_RS42120	COG2124	cytochrome p450
I6J71_RS42145	COG5002	protein histidine kinase activity
I6J71_RS42210	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS42215	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS42280	COG3033	Beta-eliminating lyase
I6J71_RS42330	COG2267	carboxylic ester hydrolase activity
I6J71_RS42335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6J71_RS42350	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS42355	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS42370	COG1309	transcriptional regulator
I6J71_RS42375	COG2318	DinB family
I6J71_RS42410	COG1846	Transcriptional regulator
I6J71_RS42430	COG1902	pentaerythritol trinitrate reductase activity
I6J71_RS42430	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J71_RS42435	COG0287	Prephenate dehydrogenase
I6J71_RS42500	COG1131	(ABC) transporter
I6J71_RS42505	COG3559	Exporter of polyketide antibiotics
I6J71_RS42540	COG2172	sigma factor antagonist activity
I6J71_RS42555	COG0667	Aldo Keto reductase
I6J71_RS42560	COG3583	domain protein
I6J71_RS42560	COG3584	3D domain protein
I6J71_RS42580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6J71_RS42590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6J71_RS42635	COG0409	Hydrogenase expression formation protein
I6J71_RS42645	COG0375	protein maturation
I6J71_RS42655	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6J71_RS42670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J71_RS42675	COG1720	tRNA m6t6A37 methyltransferase activity
I6J71_RS42715	COG1494	fructose-1,6-bisphosphatase
I6J71_RS42745	COG3279	Response regulator of the LytR AlgR family
I6J71_RS42760	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6J71_RS42765	COG1971	Probably functions as a manganese efflux pump
I6J71_RS42785	COG3588	fructose-bisphosphate aldolase
I6J71_RS42790	COG0583	DNA-binding transcription factor activity
I6J71_RS42800	COG0535	radical SAM domain protein
I6J71_RS42815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J71_RS42840	COG1309	transcriptional regulator
I6J71_RS42865	COG2124	cytochrome p450
I6J71_RS42875	COG1597	lipid kinase activity
I6J71_RS42905	COG0596	Alpha beta hydrolase
I6J71_RS43015	COG0582	viral genome integration into host DNA
I6J71_RS43035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J71_RS43045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J71_RS43065	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS43075	COG2186	Transcriptional regulator
I6J71_RS43090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J71_RS43095	COG1522	sequence-specific DNA binding
I6J71_RS43115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6J71_RS43115	COG1672	PFAM Archaeal ATPase
I6J71_RS43120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J71_RS43130	COG2329	Antibiotic biosynthesis monooxygenase
I6J71_RS43150	COG1116	anion transmembrane transporter activity
I6J71_RS43155	COG3290	protein histidine kinase activity
I6J71_RS43160	COG4565	transcriptional regulatory protein
I6J71_RS43210	COG2234	aminopeptidase activity
I6J71_RS43215	COG1063	alcohol dehydrogenase
I6J71_RS43230	COG0596	Alpha beta hydrolase
I6J71_RS43240	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I6J71_RS43245	COG1086	Polysaccharide biosynthesis protein
I6J71_RS43250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J71_RS43260	COG2089	acid synthase
I6J71_RS43290	COG1216	Glycosyl transferase, family 2
I6J71_RS43320	COG1216	Glycosyl transferase, family 2
I6J71_RS43330	COG0277	FAD linked oxidase domain protein
I6J71_RS43335	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS43375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J71_RS43395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS43400	COG0561	phosphatase activity
I6J71_RS43435	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS43440	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS43450	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J71_RS43455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J71_RS43480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J71_RS43495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6J71_RS43505	COG0579	oxidoreductase
I6J71_RS43525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J71_RS43530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J71_RS43535	COG0596	Alpha beta hydrolase
I6J71_RS43545	COG0754	glutathionylspermidine amidase activity
I6J71_RS43575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J71_RS43580	COG0406	alpha-ribazole phosphatase activity
I6J71_RS43590	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J71_RS43595	COG1072	(Pantothenic acid kinase))
I6J71_RS43610	COG4715	Zinc finger, swim domain protein
I6J71_RS43635	COG4988	ABC transporter
I6J71_RS43640	COG1294	oxidase, subunit
I6J71_RS43645	COG1271	oxidase subunit
I6J71_RS43710	COG1191	sigma factor activity
I6J71_RS43730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J71_RS43740	COG2814	Major facilitator Superfamily
I6J71_RS43765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS43775	COG3279	Response regulator of the LytR AlgR family
I6J71_RS43785	COG3275	phosphorelay sensor kinase activity
I6J71_RS43795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J71_RS43850	COG0438	transferase activity, transferring glycosyl groups
I6J71_RS43865	COG2197	response regulator
I6J71_RS43870	COG4585	Histidine kinase
I6J71_RS43880	COG0477	Major facilitator Superfamily
I6J71_RS43920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6J71_RS43930	COG1073	alpha beta
I6J71_RS43930	COG2226	methyltransferase
I6J71_RS43950	COG1733	regulation of RNA biosynthetic process
I6J71_RS43965	COG1174	glycine betaine transport
I6J71_RS43990	COG1276	copper resistance
I6J71_RS43990	COG2372	response to copper ion
I6J71_RS44020	COG2211	Major facilitator Superfamily
I6J71_RS44030	COG1309	transcriptional regulator
I6J71_RS44035	COG0789	Transcriptional regulator
I6J71_RS44055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J71_RS44060	COG0702	epimerase
I6J71_RS44085	COG1012	belongs to the aldehyde dehydrogenase family
I6J71_RS44090	COG4608	Belongs to the ABC transporter superfamily
I6J71_RS44095	COG0444	Belongs to the ABC transporter superfamily
I6J71_RS44100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS44110	COG0747	negative chemotaxis
I6J71_RS44115	COG2186	Transcriptional regulator
I6J71_RS44190	COG1716	ATPase activity
I6J71_RS44195	COG1716	ATPase activity
I6J71_RS44210	COG0768	penicillin binding
I6J71_RS44215	COG0515	serine threonine protein kinase
I6J71_RS44220	COG2815	serine threonine protein kinase
I6J71_RS44220	COG0515	serine threonine protein kinase
I6J71_RS44260	COG1131	(ABC) transporter
I6J71_RS44285	COG3764	Sortase (surface protein transpeptidase)
I6J71_RS44305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J71_RS44365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J71_RS44365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J71_RS44390	COG0673	inositol 2-dehydrogenase activity
I6J71_RS44405	COG1609	Transcriptional regulator
I6J71_RS44415	COG0800	Aldolase
I6J71_RS44420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J71_RS44430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J71_RS44435	COG1518	maintenance of DNA repeat elements
I6J71_RS44450	COG1857	crispr-associated protein
I6J71_RS44485	COG2801	Transposase and inactivated derivatives
I6J71_RS44560	COG0546	phosphoglycolate phosphatase activity
I6J71_RS44590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J71_RS44595	COG0187	DNA topoisomerase II activity
I6J71_RS44600	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6J71_RS44605	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J71_RS44610	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J71_RS44615	COG0592	DNA-directed DNA polymerase activity
I6J71_RS44625	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J71_RS44635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J71_RS44640	COG0706	membrane insertase activity
I6J71_RS44655	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J71_RS44660	COG1192	Involved in chromosome partitioning
I6J71_RS44675	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J71_RS44700	COG3409	Peptidoglycan-binding domain 1 protein
I6J71_RS44700	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J71_RS44705	COG0492	ferredoxin-NADP+ reductase activity
I6J71_RS44705	COG3118	belongs to the thioredoxin family
I6J71_RS44720	COG1595	DNA-templated transcription, initiation
I6J71_RS44745	COG0617	tRNA 3'-terminal CCA addition
I6J71_RS44750	COG4585	Histidine kinase
I6J71_RS44790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6J71_RS44810	COG0495	leucyl-tRNA aminoacylation
I6J71_RS44845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J71_RS44850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J71_RS44865	COG2197	response regulator
I6J71_RS44870	COG3920	Histidine kinase
I6J71_RS44890	COG3384	dioxygenase
I6J71_RS44935	COG0359	binds to the 23S rRNA
I6J71_RS44940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J71_RS44950	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J71_RS44985	COG0673	inositol 2-dehydrogenase activity
I6J71_RS44990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J71_RS44995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J71_RS45005	COG1695	Transcriptional regulator
I6J71_RS45015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J71_RS45025	COG2814	Major facilitator Superfamily
I6J71_RS45040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J71_RS45045	COG4221	oxidoreductase activity
I6J71_RS45050	COG0402	S-adenosylhomocysteine deaminase activity
I6J71_RS45065	COG2197	response regulator
I6J71_RS45075	COG1136	(ABC) transporter
I6J71_RS45085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J71_RS45100	COG1131	(ABC) transporter
I6J71_RS45115	COG2197	response regulator
I6J71_RS45120	COG4585	Histidine kinase
I6J71_RS45135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J71_RS45150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6J71_RS45160	COG1131	(ABC) transporter
I6J71_RS45205	COG0454	-acetyltransferase
I6J71_RS45205	COG0456	acetyltransferase
I6J71_RS45230	COG0183	Belongs to the thiolase family
I6J71_RS45235	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS45240	COG2030	dehydratase
I6J71_RS45245	COG1309	transcriptional regulator
I6J71_RS45290	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6J71_RS45295	COG4133	protoheme IX ABC transporter activity
I6J71_RS45310	COG2197	response regulator
I6J71_RS45340	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_RS45345	COG0022	dehydrogenase e1 component
I6J71_RS45355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J71_RS45365	COG0765	amino acid transport
I6J71_RS45370	COG1126	abc transporter atp-binding protein
I6J71_RS45410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J71_RS45425	COG1960	acyl-CoA dehydrogenase activity
I6J71_RS45430	COG2197	response regulator
I6J71_RS45435	COG3663	DNA glycosylase
I6J71_RS45450	COG4085	toxin activity
I6J71_RS45450	COG0737	Belongs to the 5'-nucleotidase family
I6J71_RS45450	COG1525	nuclease
I6J71_RS45475	COG3795	YCII-related domain
I6J71_RS45480	COG4941	Belongs to the sigma-70 factor family
I6J71_RS45525	COG0477	Major facilitator Superfamily
I6J71_RS45530	COG2340	Cysteine-rich secretory protein family
I6J71_RS45545	COG0247	lactate metabolic process
I6J71_RS45545	COG2181	nitrate reductase activity
I6J71_RS45550	COG2076	Multidrug Resistance protein
I6J71_RS45580	COG0443	Heat shock 70 kDa protein
I6J71_RS45585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J71_RS45590	COG0484	heat shock protein binding
I6J71_RS45595	COG0789	Transcriptional regulator
I6J71_RS45605	COG1017	nitric oxide dioxygenase activity
I6J71_RS45605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J71_RS45630	COG0542	response to heat
I6J71_RS45645	COG4221	oxidoreductase activity
I6J71_RS45650	COG0577	efflux transmembrane transporter activity
I6J71_RS45650	COG1136	(ABC) transporter
I6J71_RS45680	COG1302	Protein conserved in bacteria
I6J71_RS45690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J71_RS45730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J71_RS45735	COG0572	uridine kinase
I6J71_RS45740	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS45755	COG0586	Pfam SNARE associated Golgi protein
I6J71_RS45775	COG3467	pyridoxamine 5'-phosphate
I6J71_RS45780	COG0277	FAD linked oxidase domain protein
I6J71_RS45785	COG0586	Pfam SNARE associated Golgi protein
I6J71_RS45830	COG0667	Aldo Keto reductase
I6J71_RS45905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS45910	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS45915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS45920	COG2267	carboxylic ester hydrolase activity
I6J71_RS45925	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS45930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J71_RS45940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS45940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS45960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J71_RS45975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J71_RS45980	COG0584	glycerophosphoryl diester phosphodiesterase
I6J71_RS46025	COG0436	Aminotransferase
I6J71_RS46075	COG1175	transmembrane transport
I6J71_RS46080	COG0395	ABC-type sugar transport system, permease component
I6J71_RS46095	COG0800	Aldolase
I6J71_RS46115	COG4948	Mandelate Racemase Muconate Lactonizing
I6J71_RS46125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J71_RS46150	COG0765	amino acid transport
I6J71_RS46155	COG1126	abc transporter atp-binding protein
I6J71_RS46175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J71_RS46195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS46200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J71_RS46215	COG0318	PFAM AMP-dependent synthetase and ligase
I6J71_RS46240	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS46270	COG1309	transcriptional regulator
I6J71_RS46310	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J71_RS46315	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J71_RS46325	COG1132	(ABC) transporter
I6J71_RS46330	COG1132	(ABC) transporter
I6J71_RS46390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J71_RS46395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6J71_RS46445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J71_RS46460	COG1984	allophanate hydrolase subunit 2
I6J71_RS46465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J71_RS46470	COG4044	May play a role in the intracellular transport of hydrophobic ligands
I6J71_RS46500	COG0745	RESPONSE REGULATOR receiver
I6J71_RS46525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J71_RS46545	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J71_RS46550	COG0596	Alpha beta hydrolase
I6J71_RS46580	COG1674	ftsk spoiiie
I6J71_RS46600	COG0464	growth
I6J71_RS46665	COG1397	ADP-ribosylglycohydrolase
I6J71_RS46670	COG2188	Transcriptional regulator
I6J71_RS46690	COG1063	alcohol dehydrogenase
I6J71_RS46715	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J71_RS46715	COG0596	Alpha beta hydrolase
I6J71_RS46720	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS46725	COG0431	NADPH-dependent FMN reductase
I6J71_RS46740	COG2197	response regulator
I6J71_RS46745	COG2267	carboxylic ester hydrolase activity
I6J71_RS46750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS46750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J71_RS46815	COG0346	lactoylglutathione lyase activity
I6J71_RS46830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J71_RS46835	COG4702	Belongs to the UPF0303 family
I6J71_RS46845	COG1473	amidohydrolase
I6J71_RS46870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J71_RS46875	COG2226	methyltransferase
I6J71_RS46895	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I6J71_RS46900	COG2843	Capsule synthesis protein
I6J71_RS46935	COG1674	ftsk spoiiie
I6J71_RS46955	COG0596	Alpha beta hydrolase
I6J71_RS47015	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J71_RS47045	COG0745	RESPONSE REGULATOR receiver
I6J71_RS47050	COG2205	protein histidine kinase activity
I6J71_RS47055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J71_RS47060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J71_RS47100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J71_RS47105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J71_RS47115	COG0463	Glycosyl transferase, family 2
I6J71_RS47145	COG0747	negative chemotaxis
I6J71_RS47150	COG0601	transmembrane transport
I6J71_RS47155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J71_RS47160	COG0444	Belongs to the ABC transporter superfamily
I6J71_RS47165	COG4608	Belongs to the ABC transporter superfamily
I6J71_RS47180	COG4941	Belongs to the sigma-70 factor family
I6J71_RS47195	COG0697	spore germination
I6J71_RS47200	COG0583	DNA-binding transcription factor activity
I6J71_RS47210	COG1028	Short-chain dehydrogenase reductase Sdr
I6J71_RS47220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J71_RS47275	COG1690	Belongs to the RtcB family
I6J71_RS47295	COG0657	acetylesterase activity
I6J71_RS47305	COG1764	response to oxidative stress
I6J71_RS47310	COG0783	Belongs to the Dps family
I6J71_RS47320	COG0076	glutamate decarboxylase activity
I6J71_RS47325	COG1902	pentaerythritol trinitrate reductase activity