locus-tag class description HUT10_RS00010 ENOG4105DYS nad(p)h dehydrogenase (quinone) HUT10_RS00045 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HUT10_RS00055 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HUT10_RS00060 ENOG4105EM7 Selenocysteine-specific translation elongation factor HUT10_RS00060 ENOG4105EM7 Selenocysteine-specific translation elongation factor HUT10_RS00070 ENOG4105EMU Dehydrogenase HUT10_RS00075 ENOG4105EBM Alpha Beta Hydrolase Fold protein HUT10_RS00115 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS00120 ENOG4105BZU Histidine kinase HUT10_RS00125 ENOG4105CKK Glycosyl transferase, family 2 HUT10_RS00130 ENOG4105CSA Coproporphyrinogen iii oxidase HUT10_RS00150 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT10_RS00195 ENOG4105CHP RNA polymerase HUT10_RS00225 ENOG4107TPY serine threonine protein kinase HUT10_RS00310 ENOG4108IXY short-chain dehydrogenase reductase HUT10_RS00330 ENOG4105CHR reductase HUT10_RS00340 ENOG4105EMU Dehydrogenase HUT10_RS00350 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUT10_RS00360 ENOG4105F0K SARP family transcriptional regulator HUT10_RS00370 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HUT10_RS00375 ENOG4105FBA Phospholipase Carboxylesterase HUT10_RS00395 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT10_RS00405 ENOG4105ENE Histidine kinase HUT10_RS00410 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS00450 ENOG4105C5H ABC transporter HUT10_RS00495 ENOG4105E0A ABC, transporter HUT10_RS00500 ENOG4105TVJ transport system, permease HUT10_RS00505 ENOG4105DQ5 transport system permease protein HUT10_RS00515 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT10_RS00535 ENOG4105BZ1 (ABC) transporter HUT10_RS00540 ENOG4105BZ1 (ABC) transporter HUT10_RS00565 ENOG4105DDW LysR family Transcriptional regulator HUT10_RS00585 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT10_RS00590 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT10_RS00595 ENOG4105E2Y ABC, transporter HUT10_RS00630 ENOG4105DYW oxidoreductase HUT10_RS00635 ENOG4105CT4 transporter HUT10_RS00640 ENOG4105CVK Glutamate decarboxylase HUT10_RS00655 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HUT10_RS00680 ENOG4105CKI cobalamin synthesis protein HUT10_RS00685 ENOG4108BT0 50S ribosomal protein L32 HUT10_RS00690 ENOG4105NRA 50s ribosomal protein l31 type b HUT10_RS00700 ENOG4105KDC 50s ribosomal protein l28 HUT10_RS00705 ENOG4105W0E 50S ribosomal protein L33 HUT10_RS00710 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT10_RS00715 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT10_RS00745 ENOG4105E39 Enoyl-CoA hydratase HUT10_RS00750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT10_RS00780 ENOG4108UW8 fha domain-containing protein HUT10_RS00795 ENOG4107SWG transcriptional regulator MERR family HUT10_RS00800 ENOG4105C3M thioredoxin reductase HUT10_RS00815 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT10_RS00835 ENOG4105CMR udp-glucose 4-epimerase HUT10_RS00880 ENOG4108Q5F Tetr family transcriptional regulator HUT10_RS00920 ENOG4105D1K glutamate--cysteine ligase HUT10_RS00925 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT10_RS00935 ENOG41067HS methyltransferase HUT10_RS00955 ENOG4107QM5 aconitate hydratase HUT10_RS00960 ENOG4105ZXU NLP P60 protein HUT10_RS00965 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT10_RS00970 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUT10_RS00975 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT10_RS00985 ENOG4107QVM von Willebrand factor, type A HUT10_RS00995 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HUT10_RS01015 ENOG4108RQS Two component transcriptional regulator (Winged helix family HUT10_RS01020 ENOG4105CSH Transporter HUT10_RS01030 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUT10_RS01045 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT10_RS01050 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT10_RS01060 ENOG4105EET magnesium chelatase HUT10_RS01070 ENOG4105C8N cysteinyl-tRNA synthetase HUT10_RS01115 ENOG4105C3R Methionine synthase HUT10_RS01120 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT10_RS01135 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUT10_RS01140 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT10_RS01150 ENOG4107QJE Chromosome Partitioning Protein HUT10_RS01185 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT10_RS01205 ENOG4105WAB arsR family transcriptional regulator HUT10_RS01225 ENOG4105PTV Nudix Hydrolase HUT10_RS01230 ENOG4105E5F proteasome HUT10_RS01235 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUT10_RS01240 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT10_RS01245 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT10_RS01260 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT10_RS01270 ENOG4105EMU Dehydrogenase HUT10_RS01280 ENOG4105KVH Transcriptional regulator HUT10_RS01290 ENOG4107TMB Transcriptional regulator HUT10_RS01300 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT10_RS01310 ENOG4105CBD Diacylglycerol kinase HUT10_RS01350 ENOG4105J0Q Transcriptional regulator HUT10_RS01380 ENOG4108RZE Tetr family transcriptional regulator HUT10_RS01385 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT10_RS01390 ENOG4108W5M transcriptional regulator HUT10_RS01395 ENOG4105EMU Dehydrogenase HUT10_RS01415 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT10_RS01420 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT10_RS01430 ENOG4108NNZ chitinase HUT10_RS01460 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT10_RS01465 ENOG4107HP6 Transcriptional regulator HUT10_RS01470 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT10_RS01505 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT10_RS01605 ENOG4108S01 response regulator HUT10_RS01610 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS01620 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT10_RS01675 ENOG4105CPF Cell wall formation (By similarity) HUT10_RS01680 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT10_RS01695 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUT10_RS01715 ENOG4105DNP FAD linked oxidase domain protein HUT10_RS01725 ENOG4105CIK Amidinotransferase HUT10_RS01785 ENOG4105D7Z glutathione synthase HUT10_RS01805 ENOG4105C7W Xanthine dehydrogenase HUT10_RS01810 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT10_RS01870 ENOG4105DQE DNA ligase HUT10_RS01880 ENOG4105DE4 1-phosphofructokinase HUT10_RS01895 ENOG4105JF0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 2 HUT10_RS01900 ENOG4105CPQ Dehydrogenase HUT10_RS01905 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT10_RS01910 ENOG41080Z8 PHOSPHOCARRIER protein HUT10_RS01945 ENOG4105C0K Gdp-mannose 4,6-dehydratase HUT10_RS01975 ENOG4108JA1 polyketide synthase HUT10_RS02110 ENOG4108JA1 polyketide synthase HUT10_RS02140 ENOG41087PP glycosyltransferase MGT family HUT10_RS02145 ENOG410804X Transcriptional regulator HUT10_RS02160 ENOG4105CPN adenine deaminase HUT10_RS02170 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT10_RS02175 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT10_RS02185 ENOG4107VIJ nudix hydrolase HUT10_RS02195 ENOG4107W53 thymidine kinase HUT10_RS02230 ENOG4105NPE arsR family transcriptional regulator HUT10_RS02245 ENOG4108JCI Transcriptional regulator HUT10_RS02260 ENOG4108SGK Tetr family transcriptional regulator HUT10_RS02265 ENOG4105CSU acyl-Coa dehydrogenase HUT10_RS02310 ENOG4106A3M Cytochrome p-450 HUT10_RS02320 ENOG4105CHP RNA polymerase HUT10_RS02345 ENOG4105E7U AraC family transcriptional regulator HUT10_RS02370 ENOG4105CHP RNA polymerase HUT10_RS02400 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS02450 ENOG41060GW HUT10_RS02455 ENOG4105CSH Transporter HUT10_RS02495 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUT10_RS02500 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUT10_RS02510 ENOG41090CE integral membrane protein HUT10_RS02525 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT10_RS02535 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUT10_RS02540 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT10_RS02570 ENOG4105CWX Alpha-1,2-mannosidase HUT10_RS02590 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUT10_RS02595 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT10_RS02610 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT10_RS02615 ENOG4105DYW oxidoreductase HUT10_RS02620 ENOG4105CPC Aldo Keto reductase HUT10_RS02655 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT10_RS02660 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT10_RS02670 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS02680 ENOG4105CI0 Citrate lyase HUT10_RS02695 ENOG4108W5M transcriptional regulator HUT10_RS02725 ENOG4105CHU acetyl-coa acetyltransferase HUT10_RS02730 ENOG4105DQE DNA ligase HUT10_RS02755 ENOG4108YIQ Alpha beta hydrolase HUT10_RS02760 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT10_RS02775 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT10_RS02780 ENOG4108SGR YheO domain-containing protein HUT10_RS02785 ENOG4105CSV Glutaminase HUT10_RS02790 ENOG4105C85 amino acid HUT10_RS02795 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS02815 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT10_RS02850 ENOG4105C7N Xanthine uracil vitamin C permease HUT10_RS02855 ENOG4107Y2X deaminase HUT10_RS02875 ENOG41060W2 glyoxylate carboligase HUT10_RS02880 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HUT10_RS02885 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HUT10_RS02895 ENOG4105JQZ Methyltransferase HUT10_RS02900 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT10_RS02930 ENOG4105VEQ Cold shock protein HUT10_RS02960 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS02965 ENOG4105DET Rhamnulokinase HUT10_RS02985 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HUT10_RS03000 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT10_RS03010 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS03065 ENOG4105C7K acetolactate synthase HUT10_RS03070 ENOG4105C5Q Transcriptional regulator HUT10_RS03085 ENOG4105BZU Histidine kinase HUT10_RS03095 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUT10_RS03120 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT10_RS03125 ENOG4105VEQ Cold shock protein HUT10_RS03135 ENOG4107T94 Endo-14-beta-xylanase HUT10_RS03145 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS03155 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT10_RS03170 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS03245 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT10_RS03255 ENOG4105DQE DNA ligase HUT10_RS03300 ENOG4105C57 major facilitator superfamily HUT10_RS03305 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HUT10_RS03380 ENOG4107QPH glycogen) synthase HUT10_RS03385 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT10_RS03415 ENOG4105ECP epimerase HUT10_RS03445 ENOG4105CZX twitching motility protein HUT10_RS03450 ENOG4107QHF type ii secretion system protein e HUT10_RS03525 ENOG4105DDC Oxidoreductase domain protein HUT10_RS03540 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT10_RS03545 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT10_RS03550 ENOG410769Z extracellular solute-binding protein family 1 HUT10_RS03560 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS03565 ENOG4105QE3 oxidoreductase HUT10_RS03630 ENOG4105CDH Citrulline--aspartate ligase HUT10_RS03645 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT10_RS03650 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT10_RS03655 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT10_RS03660 ENOG4108K8U Glycerol operon regulatory protein HUT10_RS03665 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT10_RS03690 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS03700 ENOG4108HWW ABC transporter HUT10_RS03705 ENOG4105C2J ABC transporter HUT10_RS03710 ENOG4105DFW ABC transporter HUT10_RS03715 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HUT10_RS03725 ENOG4105EF1 ribulokinase HUT10_RS03735 ENOG41062B0 ABC transporter, permease HUT10_RS03740 ENOG4107R9N ABC transporter HUT10_RS03745 ENOG4105C2J ABC transporter HUT10_RS03750 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUT10_RS03780 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HUT10_RS03795 ENOG4105ESP cell wall surface anchor family protein HUT10_RS03800 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS03825 ENOG4105EUJ GTP cyclohydrolase i HUT10_RS03890 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HUT10_RS03895 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HUT10_RS03920 ENOG4107S9B Shikimate dehydrogenase HUT10_RS03930 ENOG4105CSH Transporter HUT10_RS03945 ENOG4105DF6 Fe-S oxidoreductase HUT10_RS03970 ENOG4105JZI cytochrome P450 HUT10_RS03985 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS04000 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT10_RS04015 ENOG4105J7D transcriptional regulator HUT10_RS04020 ENOG4108YYC ycei family HUT10_RS04025 ENOG4105FS7 Transcriptional regulator HUT10_RS04030 ENOG4105CHF Glutathione S-transferase HUT10_RS04040 ENOG4105CIR epoxide hydrolase HUT10_RS04060 ENOG41070H7 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT10_RS04065 ENOG4105CPQ Dehydrogenase HUT10_RS04105 ENOG4107W6X Transcriptional regulator HUT10_RS04155 ENOG4105CIR epoxide hydrolase HUT10_RS04230 ENOG4108NBA ATP-dependent carboxylate-amine ligase (By similarity) HUT10_RS04245 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT10_RS04255 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT10_RS04270 ENOG4107FW0 short-chain dehydrogenase reductase HUT10_RS04290 ENOG4107S2Z UPF0761 membrane protein HUT10_RS04310 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HUT10_RS04335 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT10_RS04340 ENOG4107SJB teichoic acid biosynthesis HUT10_RS04355 ENOG4105CMR udp-glucose 4-epimerase HUT10_RS04365 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT10_RS04370 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT10_RS04385 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT10_RS04405 ENOG4105C26 Dehydrogenase HUT10_RS04410 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HUT10_RS04415 ENOG4105DKP glycosyl transferase, family 9 HUT10_RS04425 ENOG4107R33 ppx gppa phosphatase HUT10_RS04435 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT10_RS04480 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT10_RS04495 ENOG4105D9P serine threonine protein kinase HUT10_RS04505 ENOG4108MP6 LysR family Transcriptional regulator HUT10_RS04540 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT10_RS04545 ENOG4105EW9 transcriptional regulator AsnC family HUT10_RS04560 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT10_RS04565 ENOG4105K6V RNA polymerase HUT10_RS04570 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT10_RS04640 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT10_RS04660 ENOG4108JU3 Alkyl hydroperoxide reductase HUT10_RS04680 ENOG410645S MarR family Transcriptional regulator HUT10_RS04750 ENOG4105DQE DNA ligase HUT10_RS04790 ENOG4105DQE DNA ligase HUT10_RS04810 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT10_RS04835 ENOG4107RCI amp-dependent synthetase and ligase HUT10_RS04860 ENOG4105C57 major facilitator superfamily HUT10_RS04900 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT10_RS04925 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS04935 ENOG4107ZR7 Membrane HUT10_RS04950 ENOG4105BZU Histidine kinase HUT10_RS04955 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS05025 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS05060 ENOG4105K56 Transcriptional regulator HUT10_RS05070 ENOG4105C34 Pseudouridine synthase HUT10_RS05105 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS05130 ENOG4105CUB amino acid HUT10_RS05135 ENOG4105DKQ ROK family HUT10_RS05180 ENOG4105JQZ Methyltransferase HUT10_RS05185 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT10_RS05215 ENOG4105CPQ Dehydrogenase HUT10_RS05235 ENOG4108WYP Transcriptional regulator HUT10_RS05250 ENOG4105D2B acyl-CoA dehydrogenase HUT10_RS05255 ENOG4105D2B acyl-CoA dehydrogenase HUT10_RS05270 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS05275 ENOG4105CC9 acyl-Coa dehydrogenase HUT10_RS05280 ENOG4105CHR reductase HUT10_RS05285 ENOG4105F2C Acetyl-CoA acetyltransferase HUT10_RS05290 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT10_RS05295 ENOG4105EA8 2-Nitropropane dioxygenase HUT10_RS05310 ENOG41060WC Enoyl-CoA hydratase HUT10_RS05315 ENOG4105CHR reductase HUT10_RS05350 ENOG4105D8K carboxyl transferase HUT10_RS05365 ENOG4105C57 major facilitator superfamily HUT10_RS05370 ENOG4105EYF MMPL domain protein HUT10_RS05380 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT10_RS05395 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT10_RS05400 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT10_RS05405 ENOG4105CCF Lysine exporter protein (Lyse ygga) HUT10_RS05440 ENOG4106SPC secreted protein HUT10_RS05485 ENOG4105C7W Xanthine dehydrogenase HUT10_RS05490 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT10_RS05495 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT10_RS05500 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT10_RS05505 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HUT10_RS05525 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases HUT10_RS05560 ENOG4105BZU Histidine kinase HUT10_RS05570 ENOG4107WAU Protein tyrosine phosphatase HUT10_RS05580 ENOG4105C7B Threonine dehydratase HUT10_RS05605 ENOG4105E2D ec 3.2.1.52 HUT10_RS05610 ENOG4105FDP GntR family transcriptional regulator HUT10_RS05620 ENOG4105BZU Histidine kinase HUT10_RS05630 ENOG4105GWZ Roadblock lc7 family protein HUT10_RS05665 ENOG4105E1F short-chain dehydrogenase reductase HUT10_RS05680 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT10_RS05700 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS05775 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS05805 ENOG41084GC stage II sporulation protein HUT10_RS05830 ENOG4105E9F Enoyl-CoA hydratase HUT10_RS05835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT10_RS05870 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT10_RS05885 ENOG4105DQE DNA ligase HUT10_RS05895 ENOG4106Z5D Glycoside Hydrolase Family 43 HUT10_RS05950 ENOG4108PA7 Methyltransferase HUT10_RS05960 ENOG4105ESN nucleotide-binding protein HUT10_RS05970 ENOG4105ESN nucleotide-binding protein HUT10_RS05970 ENOG4105ESN nucleotide-binding protein HUT10_RS05980 ENOG4105CTU Proline racemase HUT10_RS05985 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT10_RS06000 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT10_RS06020 ENOG41067TZ transcriptional regulator, MarR family HUT10_RS06045 ENOG4105E33 succinate dehydrogenase HUT10_RS06060 ENOG4105DND Transcriptional regulator HUT10_RS06065 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT10_RS06115 ENOG4105C54 Major Facilitator superfamily HUT10_RS06120 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT10_RS06125 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT10_RS06130 ENOG4107WHI formate dehydrogenase, beta subunit HUT10_RS06160 ENOG4105E98 transcriptional regulator DeoR family HUT10_RS06225 ENOG4108KPJ rna polymerase sigma factor HUT10_RS06230 ENOG4105CG3 alpha amylase, catalytic region HUT10_RS06240 ENOG4105DU1 integral membrane protein, terc HUT10_RS06275 ENOG4105DSF transport protein HUT10_RS06280 ENOG41061ZR Transcriptional regulator HUT10_RS06320 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS06325 ENOG4105BZP glycoside hydrolase 15-related HUT10_RS06340 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT10_RS06370 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT10_RS06400 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS06405 ENOG4105D2B acyl-CoA dehydrogenase HUT10_RS06410 ENOG4105D2B acyl-CoA dehydrogenase HUT10_RS06430 ENOG4105YA8 Transcriptional regulator HUT10_RS06440 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS06450 ENOG4105CNT hydrolase family 2 HUT10_RS06465 ENOG4105CJ1 ABC, transporter HUT10_RS06485 ENOG4105BZU Histidine kinase HUT10_RS06490 ENOG4105JSC dimethylmenaquinone methyltransferase HUT10_RS06495 ENOG4105CXK mandelate racemase muconate lactonizing HUT10_RS06500 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT10_RS06510 ENOG4105JXH GntR family transcriptional regulator HUT10_RS06590 ENOG4105D2N Aldolase HUT10_RS06610 ENOG4105E70 isomerase HUT10_RS06615 ENOG410804X Transcriptional regulator HUT10_RS06635 ENOG4105DRS transport system, permease HUT10_RS06640 ENOG4105F8D glycoside hydrolase family 4 HUT10_RS06645 ENOG4105CYP glycoside hydrolase, family HUT10_RS06650 ENOG4105EX0 alpha-galactosidase HUT10_RS06660 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS06665 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT10_RS06700 ENOG4105H3G oxidoreductase HUT10_RS06715 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT10_RS06730 ENOG4105BZU Histidine kinase HUT10_RS06740 ENOG4105C0X amino acid HUT10_RS06785 ENOG4105NTD Inherit from COG: Hydrolase HUT10_RS06790 ENOG4105CHR reductase HUT10_RS06795 ENOG4105ERH Fumarylacetoacetate hydrolase HUT10_RS06805 ENOG41061H0 Monooxygenase HUT10_RS06820 ENOG4105D2S major facilitator superfamily HUT10_RS06835 ENOG4105NAF rna polymerase sigma factor HUT10_RS06860 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT10_RS06865 ENOG4105C2J ABC transporter HUT10_RS06900 ENOG4108R86 Transcriptional regulator HUT10_RS06920 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS06925 ENOG4105BZU Histidine kinase HUT10_RS06955 ENOG41085FC arsR family transcriptional regulator HUT10_RS06970 ENOG4108Z0Z intracellular protease Pfpi family HUT10_RS06975 ENOG4105E2A Dehydrogenase HUT10_RS06995 ENOG4105EAB amino acid AbC transporter HUT10_RS07000 ENOG4105CDA abc transporter atp-binding protein HUT10_RS07025 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS07040 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT10_RS07090 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT10_RS07100 ENOG4105E2Y ABC, transporter HUT10_RS07105 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUT10_RS07145 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HUT10_RS07155 ENOG4105DTQ mandelate racemase muconate lactonizing HUT10_RS07160 ENOG4108QMY dioxygenase HUT10_RS07175 ENOG4107HP6 Transcriptional regulator HUT10_RS07190 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT10_RS07195 ENOG4105J7D transcriptional regulator HUT10_RS07210 ENOG4108JGH Tetr family transcriptional regulator HUT10_RS07225 ENOG4108JA1 polyketide synthase HUT10_RS07230 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HUT10_RS07290 ENOG4108IG5 Transcriptional regulator HUT10_RS07310 ENOG4105DQ4 alcohol dehydrogenase HUT10_RS07475 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT10_RS07480 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT10_RS07485 ENOG4108R86 Transcriptional regulator HUT10_RS07505 ENOG4105EMU Dehydrogenase HUT10_RS07540 ENOG41074CX linocin_m18 bacteriocin protein HUT10_RS07580 ENOG4107S73 homocitrate synthase HUT10_RS07590 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS07605 ENOG4105YIP Tetr family transcriptional regulator HUT10_RS07615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT10_RS07680 ENOG4105PDP Short chain dehydrogenase HUT10_RS07710 ENOG4105DRR Transcriptional regulator, GntR family HUT10_RS07725 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT10_RS07730 ENOG4105EJC lysr family transcriptional regulator HUT10_RS07735 ENOG4105CPC Aldo Keto reductase HUT10_RS07740 ENOG4108Q5F Tetr family transcriptional regulator HUT10_RS07745 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT10_RS07750 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT10_RS07760 ENOG4105CHR reductase HUT10_RS07795 ENOG4105VRS hydrolase family 18 HUT10_RS07830 ENOG4105C0Z ABC transporter HUT10_RS07835 ENOG4108IV0 ABC, transporter HUT10_RS07860 ENOG4105EFZ amidohydrolase HUT10_RS07885 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT10_RS07910 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT10_RS07915 ENOG4105CPN adenine deaminase HUT10_RS07920 ENOG4105CPQ Dehydrogenase HUT10_RS07950 ENOG4105ERH Fumarylacetoacetate hydrolase HUT10_RS07955 ENOG4105DRR Transcriptional regulator, GntR family HUT10_RS07960 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT10_RS07975 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT10_RS08080 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS08135 ENOG4105VBF alkaline shock protein HUT10_RS08170 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT10_RS08190 ENOG4105CNA YD repeat protein HUT10_RS08190 ENOG4105CNA YD repeat protein HUT10_RS08195 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT10_RS08200 ENOG4107S9D Alpha beta hydrolase HUT10_RS08220 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HUT10_RS08225 ENOG4105CSH Transporter HUT10_RS08235 ENOG4108M9J MaoC like domain protein HUT10_RS08250 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS08275 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS08285 ENOG4107HP6 Transcriptional regulator HUT10_RS08290 ENOG4105IKQ hydratase HUT10_RS08295 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HUT10_RS08300 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUT10_RS08390 ENOG4105CH6 catalase HUT10_RS08430 ENOG4105K56 Transcriptional regulator HUT10_RS08440 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT10_RS08450 ENOG4105CSH Transporter HUT10_RS08455 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT10_RS08475 ENOG4105E39 Enoyl-CoA hydratase HUT10_RS08480 ENOG4108Z4U Ferredoxin HUT10_RS08485 ENOG4105CAY ferredoxin--nadp reductase HUT10_RS08495 ENOG4105DP7 Protocatechuate 4,5-dioxygenase HUT10_RS08520 ENOG4108FUF Transcriptional regulator, IclR family HUT10_RS08525 ENOG4105EBR Carboxylesterase HUT10_RS08555 ENOG4108JA1 polyketide synthase HUT10_RS08600 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT10_RS08670 ENOG41062D9 Histidine kinase HUT10_RS08685 ENOG4105EDW glycosyl transferase, family 39 HUT10_RS08705 ENOG4105WEM extracellular solute-binding protein HUT10_RS08730 ENOG4105EQ2 LysR family Transcriptional regulator HUT10_RS08750 ENOG4105CDA abc transporter atp-binding protein HUT10_RS08775 ENOG4107TTQ Alpha beta hydrolase fold HUT10_RS08800 ENOG4108R85 Short chain dehydrogenase HUT10_RS08810 ENOG4105VBF alkaline shock protein HUT10_RS08870 ENOG4105BZP glycoside hydrolase 15-related HUT10_RS08885 ENOG4105K6V RNA polymerase HUT10_RS08890 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT10_RS08920 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT10_RS08985 ENOG4107VGF ig domain protein group 2 domain protein HUT10_RS09020 ENOG4105DU6 RNA polymerase HUT10_RS09080 ENOG4105VBF alkaline shock protein HUT10_RS09110 ENOG4105VBF alkaline shock protein HUT10_RS09120 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUT10_RS09145 ENOG41060NJ transcriptional regulator HUT10_RS09170 ENOG4105G9B Transcriptional regulator HUT10_RS09175 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS09180 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS09230 ENOG4105EYF MMPL domain protein HUT10_RS09250 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT10_RS09340 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUT10_RS09345 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT10_RS09350 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT10_RS09370 ENOG4105C0X amino acid HUT10_RS09500 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS09610 ENOG4105EC2 ftsk spoIIIe HUT10_RS09645 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT10_RS09660 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HUT10_RS09670 ENOG4106F1P AAA ATPase, central domain protein HUT10_RS09700 ENOG4108S01 response regulator HUT10_RS09735 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS09745 ENOG4107QPD alcohol dehydrogenase HUT10_RS09760 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HUT10_RS09785 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT10_RS09835 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS09855 ENOG4105C84 Histidine ammonia-lyase HUT10_RS09870 ENOG4107STQ Multicopper oxidase HUT10_RS09905 ENOG4105C57 major facilitator superfamily HUT10_RS09915 ENOG4108KK4 3-dehydroquinate synthase HUT10_RS09925 ENOG4105DC7 peptidase M24 HUT10_RS09935 ENOG4106A3M Cytochrome p-450 HUT10_RS09970 ENOG4105Q56 cytochrome P450 HUT10_RS09975 ENOG4107RCI amp-dependent synthetase and ligase HUT10_RS10010 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT10_RS10020 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS10030 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT10_RS10075 ENOG4105D9P serine threonine protein kinase HUT10_RS10145 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT10_RS10195 ENOG4105ENX hydrolase HUT10_RS10275 ENOG4105C0B DNA polymerase III (alpha subunit) HUT10_RS10325 ENOG4105C0B DNA polymerase III (alpha subunit) HUT10_RS10465 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS10505 ENOG4105C84 Histidine ammonia-lyase HUT10_RS10900 ENOG4105ZXU NLP P60 protein HUT10_RS11095 ENOG4105CYP glycoside hydrolase, family HUT10_RS11110 ENOG4105FP9 thiamine pyrophosphate HUT10_RS11120 ENOG4105D2S major facilitator superfamily HUT10_RS11155 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT10_RS11160 ENOG4108Z6Z Transcriptional regulator HUT10_RS11165 ENOG41082SX arsR family transcriptional regulator HUT10_RS11190 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT10_RS11215 ENOG4105EPJ extracellular solute-binding protein family 1 HUT10_RS11245 ENOG4105DVE abc transporter atp-binding protein HUT10_RS11250 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT10_RS11255 ENOG4106IPI cyclase, family HUT10_RS11260 ENOG4105C7K acetolactate synthase HUT10_RS11275 ENOG4108VVK transcriptional Regulator, AsnC HUT10_RS11285 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS11300 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT10_RS11310 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT10_RS11320 ENOG4105CGD Nad-dependent epimerase dehydratase HUT10_RS11335 ENOG4107RSM transcriptional regulator HUT10_RS11340 ENOG4105C7B Threonine dehydratase HUT10_RS11410 ENOG4108IXY short-chain dehydrogenase reductase HUT10_RS11415 ENOG4105EMU Dehydrogenase HUT10_RS11420 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HUT10_RS11510 ENOG4108MUZ hydrolase HUT10_RS11565 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT10_RS11610 ENOG4105D9P serine threonine protein kinase HUT10_RS11620 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT10_RS11625 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUT10_RS11655 ENOG4105FBN Acid phosphatase HUT10_RS11795 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT10_RS11805 ENOG4105DEG Vwa containing coxe family protein HUT10_RS11830 ENOG4106AM8 polysaccharide lyase family 8 HUT10_RS11845 ENOG4105EQX glucarate dehydratase HUT10_RS11850 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HUT10_RS11860 ENOG4106P37 HTH-type transcriptional regulator YjhI HUT10_RS11865 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HUT10_RS11945 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT10_RS11955 ENOG4105CAT Cytidine monophosphate kinase HUT10_RS11975 ENOG4107S91 Sodium hydrogen exchanger HUT10_RS11990 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT10_RS12000 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT10_RS12035 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT10_RS12055 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HUT10_RS12095 ENOG4108UYE Lactoylglutathione lyase HUT10_RS12105 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT10_RS12120 ENOG4105DSU hydrolase HUT10_RS12145 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT10_RS12150 ENOG4108VX5 3-methyladenine DNA glycosylase HUT10_RS12155 ENOG4105CH7 arginosuccinase HUT10_RS12165 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUT10_RS12170 ENOG4105DBV ornithine carbamoyltransferase HUT10_RS12175 ENOG4105C8Y Acetylornithine aminotransferase HUT10_RS12180 ENOG4105CAS nag kinase HUT10_RS12185 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT10_RS12190 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT10_RS12205 ENOG4106JDR secreted HUT10_RS12215 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT10_RS12220 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT10_RS12230 ENOG4108RWN rrna methyltransferase HUT10_RS12235 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT10_RS12240 ENOG41084BS 50S ribosomal protein L35 HUT10_RS12265 ENOG4105K6H D-cysteine desulfhydrase HUT10_RS12270 ENOG4105KME endoribonuclease L-psp HUT10_RS12295 ENOG4105C6Z Gluconate HUT10_RS12340 ENOG4108MRH transcriptional regulatory protein HUT10_RS12345 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT10_RS12350 ENOG4107QJT sodium dicarboxylate symporter HUT10_RS12355 ENOG4105KVH Transcriptional regulator HUT10_RS12400 ENOG4105C5X domain protein HUT10_RS12430 ENOG4105EYW Ion transport protein HUT10_RS12435 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT10_RS12440 ENOG4105K5B UPF0225 protein HUT10_RS12460 ENOG4105EBR Carboxylesterase HUT10_RS12470 ENOG4105CVJ phosphoglycerate mutase HUT10_RS12490 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS12510 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HUT10_RS12515 ENOG4105DU1 integral membrane protein, terc HUT10_RS12520 ENOG4105CJ1 ABC, transporter HUT10_RS12530 ENOG4105CGU Enoyl-CoA hydratase HUT10_RS12575 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT10_RS12595 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT10_RS12815 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT10_RS12820 ENOG4105DMQ Methyltransferase HUT10_RS12840 ENOG4105ECB domain protein HUT10_RS12845 ENOG4108IG5 Transcriptional regulator HUT10_RS12895 ENOG4105C32 Amino acid ABC transporter (Permease) HUT10_RS12900 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT10_RS12905 ENOG4105C0Z ABC transporter HUT10_RS12910 ENOG4108IV0 ABC, transporter HUT10_RS12985 ENOG4105CIS alcohol dehydrogenase HUT10_RS13010 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT10_RS13025 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT10_RS13060 ENOG4105ECQ AraC Family Transcriptional Regulator HUT10_RS13085 ENOG4107U32 Beta-lactamase domain protein HUT10_RS13105 ENOG4107SCK Monooxygenase HUT10_RS13115 ENOG4107S5I aldo keto reductase HUT10_RS13120 ENOG4107RSM transcriptional regulator HUT10_RS13155 ENOG4105KVH Transcriptional regulator HUT10_RS13185 ENOG4105VMI -acetyltransferase HUT10_RS13200 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT10_RS13260 ENOG4105BZU Histidine kinase HUT10_RS13265 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS13290 ENOG4108SHN Glycosyl transferase, family 2 HUT10_RS13300 ENOG4105C8Y Acetylornithine aminotransferase HUT10_RS13305 ENOG41061ZR Transcriptional regulator HUT10_RS13400 ENOG4105WQT MbtH domain protein HUT10_RS13465 ENOG4105EQ0 Major Facilitator superfamily HUT10_RS13495 ENOG4105ME9 cell division protein FtsQ HUT10_RS13500 ENOG4105DFU Cell wall formation (By similarity) HUT10_RS13515 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT10_RS13520 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT10_RS13535 ENOG4105CJN penicillin-binding protein HUT10_RS13545 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT10_RS13550 ENOG4108V6E Cell division protein mraZ HUT10_RS13575 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT10_RS13605 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HUT10_RS13610 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUT10_RS13615 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT10_RS13625 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT10_RS13630 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT10_RS13645 ENOG4105WBV Transcriptional regulator HUT10_RS13660 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT10_RS13685 ENOG4107QZI cell division protein FtsK HUT10_RS13715 ENOG4105C85 amino acid HUT10_RS13735 ENOG4105CN5 Metallo-Beta-Lactamase HUT10_RS13740 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT10_RS13745 ENOG4107TPY serine threonine protein kinase HUT10_RS13775 ENOG4108Z6Z Transcriptional regulator HUT10_RS13820 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase HUT10_RS13830 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT10_RS13840 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT10_RS13845 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT10_RS13865 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT10_RS13895 ENOG4105DZ6 Band 7 protein HUT10_RS13910 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT10_RS13930 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT10_RS13940 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUT10_RS13950 ENOG4105CHV Transcription elongation factor NusA HUT10_RS13955 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT10_RS13990 ENOG4105W1N transcriptional regulator HUT10_RS14000 ENOG4105BZU Histidine kinase HUT10_RS14005 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS14015 ENOG4105KVH Transcriptional regulator HUT10_RS14025 ENOG4108IG5 Transcriptional regulator HUT10_RS14050 ENOG4105BZU Histidine kinase HUT10_RS14055 ENOG4108W5M transcriptional regulator HUT10_RS14065 ENOG4106YT9 Enoyl-CoA hydratase HUT10_RS14075 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HUT10_RS14080 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS14085 ENOG4107TB5 TRANSCRIPTIONal HUT10_RS14115 ENOG4107NQ8 LysR family Transcriptional regulator HUT10_RS14120 ENOG4105DHU Bile acid HUT10_RS14150 ENOG4108W5M transcriptional regulator HUT10_RS14155 ENOG4108M8W Monooxygenase HUT10_RS14240 ENOG4105EEF Alkane 1-monooxygenase HUT10_RS14280 ENOG4108KPJ rna polymerase sigma factor HUT10_RS14305 ENOG4105DSG hydrolase family 43 HUT10_RS14350 ENOG4105CHR reductase HUT10_RS14385 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT10_RS14400 ENOG4108KPJ rna polymerase sigma factor HUT10_RS14450 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT10_RS14460 ENOG4108S01 response regulator HUT10_RS14465 ENOG4105BZU Histidine kinase HUT10_RS14475 ENOG4108M15 ABC transporter HUT10_RS14480 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT10_RS14515 ENOG4108PJD permease HUT10_RS14525 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT10_RS14530 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT10_RS14560 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT10_RS14575 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT10_RS14585 ENOG4105K59 histidine triad (HIT) protein HUT10_RS14595 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT10_RS14600 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT10_RS14625 ENOG4105CPC Aldo Keto reductase HUT10_RS14635 ENOG4105C26 Dehydrogenase HUT10_RS14645 ENOG4105ZSU inhibitor HUT10_RS14665 ENOG4105EB3 Histidine kinase HUT10_RS14670 ENOG4108PYU two-component system response regulator HUT10_RS14675 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HUT10_RS14685 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HUT10_RS14725 ENOG4105D9P serine threonine protein kinase HUT10_RS14735 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT10_RS14745 ENOG4105IDI abc transporter atp-binding protein HUT10_RS14800 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT10_RS14830 ENOG4108M7F enoyl-CoA hydratase isomerase HUT10_RS14835 ENOG41067XF inhibitor HUT10_RS14850 ENOG4105CB2 alcohol dehydrogenase HUT10_RS14860 ENOG4105CUB amino acid HUT10_RS14865 ENOG4105EA8 2-Nitropropane dioxygenase HUT10_RS14880 ENOG4105E2D ec 3.2.1.52 HUT10_RS14915 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS14930 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT10_RS14945 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HUT10_RS14955 ENOG4105EPR degv family HUT10_RS14965 ENOG4105CVJ phosphoglycerate mutase HUT10_RS14970 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HUT10_RS14975 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT10_RS14980 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT10_RS14985 ENOG4105CSH Transporter HUT10_RS14990 ENOG4105C75 arginyL-tRNA synthetase HUT10_RS15005 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT10_RS15010 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT10_RS15015 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT10_RS15020 ENOG4105K46 50S ribosomal protein l27 HUT10_RS15025 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT10_RS15030 ENOG4105C03 ribonuclease HUT10_RS15030 ENOG4105C03 ribonuclease HUT10_RS15050 ENOG4105CJ1 ABC, transporter HUT10_RS15065 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT10_RS15130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT10_RS15145 ENOG4107TTQ Alpha beta hydrolase fold HUT10_RS15150 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HUT10_RS15155 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS15165 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT10_RS15185 ENOG41080V3 Major Facilitator superfamily HUT10_RS15200 ENOG4107TB5 TRANSCRIPTIONal HUT10_RS15205 ENOG4105CHR reductase HUT10_RS15215 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT10_RS15245 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT10_RS15250 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT10_RS15255 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT10_RS15260 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT10_RS15270 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT10_RS15280 ENOG4105BZU Histidine kinase HUT10_RS15285 ENOG4105EDW glycosyl transferase, family 39 HUT10_RS15315 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HUT10_RS15350 ENOG4105EDW glycosyl transferase, family 39 HUT10_RS15390 ENOG4105CWX Alpha-1,2-mannosidase HUT10_RS15405 ENOG4105CPN adenine deaminase HUT10_RS15410 ENOG4105DIM ABC transporter HUT10_RS15415 ENOG4105CIG ABC transporter HUT10_RS15420 ENOG4108X07 Tetr family transcriptional regulator HUT10_RS15430 ENOG4105E2R ROK family HUT10_RS15470 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase HUT10_RS15485 ENOG4105F27 Major Facilitator HUT10_RS15490 ENOG4105CV8 reductase HUT10_RS15520 ENOG4108Z0Z intracellular protease Pfpi family HUT10_RS15525 ENOG4107SGM protein serine threonine phosphatase HUT10_RS15530 ENOG4105BZU Histidine kinase HUT10_RS15555 ENOG4105KVH Transcriptional regulator HUT10_RS15560 ENOG4105EX0 alpha-galactosidase HUT10_RS15585 ENOG4108JA1 polyketide synthase HUT10_RS15685 ENOG4106A3M Cytochrome p-450 HUT10_RS15690 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT10_RS15710 ENOG41087PP glycosyltransferase MGT family HUT10_RS15715 ENOG4105CJ1 ABC, transporter HUT10_RS15725 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS15730 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT10_RS15740 ENOG4105C0K Gdp-mannose 4,6-dehydratase HUT10_RS15780 ENOG4108YZG isomerase HUT10_RS15795 ENOG4105MC2 DSBA oxidoreductase HUT10_RS15805 ENOG4109057 HUT10_RS15820 ENOG4105D8X mechanosensitive ion channel HUT10_RS15830 ENOG4105CG3 alpha amylase, catalytic region HUT10_RS15845 ENOG4108TGP Thioesterase superfamily protein HUT10_RS15850 ENOG4105C7I Dehydrogenase HUT10_RS15865 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein HUT10_RS15925 ENOG4105C57 major facilitator superfamily HUT10_RS15935 ENOG4108VQT Alpha beta hydrolase fold protein HUT10_RS15945 ENOG4107QQG Dehydrogenase HUT10_RS15950 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT10_RS16005 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS16045 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HUT10_RS16120 ENOG4105D8K carboxyl transferase HUT10_RS16195 ENOG4105E7U AraC family transcriptional regulator HUT10_RS16210 ENOG4105CHP RNA polymerase HUT10_RS16215 ENOG4105GRZ Ycii-related protein HUT10_RS16225 ENOG4107RTD sua5 ycio yrdc ywlc family protein HUT10_RS16245 ENOG4105E7U AraC family transcriptional regulator HUT10_RS16250 ENOG4108S01 response regulator HUT10_RS16255 ENOG4105BZU Histidine kinase HUT10_RS16300 ENOG4105VPX protein, conserved in bacteria HUT10_RS16345 ENOG4105C0B DNA polymerase III (alpha subunit) HUT10_RS16365 ENOG4108IJ0 Aspartate ammonia-lyase HUT10_RS16405 ENOG4105C3J Cysteine desulfurase HUT10_RS16415 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS16445 ENOG4105C57 major facilitator superfamily HUT10_RS16470 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT10_RS16480 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT10_RS16490 ENOG4105DAA L-lactate HUT10_RS16510 ENOG4105RHA ABC transporter, permease HUT10_RS16515 ENOG4108IUX (ABC) transporter HUT10_RS16530 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT10_RS16560 ENOG4107QN2 dihydrolipoyl dehydrogenase HUT10_RS16575 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HUT10_RS16580 ENOG4105W8H transhydrogenase (subunit alpha HUT10_RS16585 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HUT10_RS16590 ENOG4105EJ2 Transcriptional regulator HUT10_RS16595 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT10_RS16635 ENOG4105FF5 Membrane HUT10_RS16660 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT10_RS16675 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HUT10_RS16695 ENOG4107XFJ UPF0246 protein HUT10_RS16700 ENOG4107VFR oxidoreductase HUT10_RS16710 ENOG4108Q5F Tetr family transcriptional regulator HUT10_RS16715 ENOG4108XW1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT10_RS16720 ENOG4108W5M transcriptional regulator HUT10_RS16760 ENOG4105C1J atp-dependent rna helicase HUT10_RS16775 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap HUT10_RS16805 ENOG4105JXH GntR family transcriptional regulator HUT10_RS16840 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT10_RS16860 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT10_RS16865 ENOG4105DZP Membrane-associated zinc metalloprotease HUT10_RS16870 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUT10_RS16880 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HUT10_RS16935 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HUT10_RS16950 ENOG4105CHR reductase HUT10_RS16955 ENOG4105ES4 Nitrilase HUT10_RS16965 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT10_RS16970 ENOG4108222 arsenate reductase HUT10_RS16985 ENOG4105CHP RNA polymerase HUT10_RS16990 ENOG4105GRZ Ycii-related protein HUT10_RS17025 ENOG4105VUF Transcriptional regulator HUT10_RS17075 ENOG4105CFG Acts as a chaperone (By similarity) HUT10_RS17080 ENOG4108M24 von Willebrand factor, type A HUT10_RS17165 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT10_RS17175 ENOG4105DZC cytosine deaminase HUT10_RS17215 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT10_RS17225 ENOG4105CV1 Transketolase (EC 2.2.1.1) HUT10_RS17235 ENOG4108MES Periplasmic binding protein HUT10_RS17245 ENOG4105TVJ transport system, permease HUT10_RS17250 ENOG4105DQ5 transport system permease protein HUT10_RS17275 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT10_RS17280 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT10_RS17285 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT10_RS17290 ENOG4105CE9 30S ribosomal protein S2 HUT10_RS17300 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT10_RS17305 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT10_RS17325 ENOG41080R2 UPF0102 protein HUT10_RS17335 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT10_RS17340 ENOG4107QYR Signal peptidase i HUT10_RS17345 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT10_RS17350 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT10_RS17355 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT10_RS17365 ENOG4105K5M 30s ribosomal protein S16 HUT10_RS17390 ENOG4105BZ1 (ABC) transporter HUT10_RS17400 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT10_RS17410 ENOG4105M4P Tetr family transcriptional regulator HUT10_RS17415 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT10_RS17420 ENOG4105BZU Histidine kinase HUT10_RS17425 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT10_RS17450 ENOG4108KPJ rna polymerase sigma factor HUT10_RS17455 ENOG4105C5Q Transcriptional regulator HUT10_RS17475 ENOG4105K4P CoA-binding domain protein HUT10_RS17495 ENOG4105EMN RNA polymerase sigma factor HUT10_RS17535 ENOG4105J7D transcriptional regulator HUT10_RS17540 ENOG4105EX0 alpha-galactosidase HUT10_RS17545 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT10_RS17550 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT10_RS17575 ENOG4105CK2 sodium dicarboxylate symporter HUT10_RS17600 ENOG4107R9S Malate synthase HUT10_RS17605 ENOG41069M3 Transcriptional regulator HUT10_RS17630 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HUT10_RS17635 ENOG4107RUZ Sss sodium solute transporter superfamily HUT10_RS17655 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HUT10_RS17680 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUT10_RS17685 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT10_RS17690 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT10_RS17700 ENOG4105CAQ asparagine synthetase HUT10_RS17710 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT10_RS17720 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HUT10_RS17730 ENOG4105CNN ABC, transporter HUT10_RS17735 ENOG4105C2J ABC transporter HUT10_RS17740 ENOG4105EDK PfkB domain protein HUT10_RS17745 ENOG4105DH8 myo-inositol catabolism HUT10_RS17750 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUT10_RS17775 ENOG4105CPC Aldo Keto reductase HUT10_RS17785 ENOG4105BZU Histidine kinase HUT10_RS17830 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT10_RS17835 ENOG410801B Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HUT10_RS17840 ENOG4107HP6 Transcriptional regulator HUT10_RS17845 ENOG4108Z8I decarboxylase HUT10_RS17850 ENOG4105F2Z 3-oxoadipate enol-lactonase HUT10_RS17855 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HUT10_RS17865 ENOG4105CHU acetyl-coa acetyltransferase HUT10_RS17885 ENOG4105DRS transport system, permease HUT10_RS17895 ENOG4107FKK extracellular solute-binding protein family 1 HUT10_RS17915 ENOG4105BZW Glycerate kinase HUT10_RS17935 ENOG4105VG5 Membrane HUT10_RS17960 ENOG4105JXH GntR family transcriptional regulator HUT10_RS17965 ENOG4105CNN ABC, transporter HUT10_RS17970 ENOG4105C2J ABC transporter HUT10_RS17980 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT10_RS17985 ENOG4105DIA mandelate racemase muconate lactonizing HUT10_RS17990 ENOG4105ERH Fumarylacetoacetate hydrolase HUT10_RS17995 ENOG4105C2C drug resistance transporter, Bcr CflA HUT10_RS18005 ENOG4107TXC Transcriptional regulator HUT10_RS18030 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT10_RS18035 ENOG4107SQD Transcriptional regulator, GntR family HUT10_RS18045 ENOG4105BZ4 penicillin-binding protein HUT10_RS18050 ENOG41073TP transcriptional regulator HUT10_RS18060 ENOG4105EJQ L-serine dehydratase HUT10_RS18065 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT10_RS18070 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT10_RS18075 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUT10_RS18080 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT10_RS18085 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT10_RS18110 ENOG4105C26 Dehydrogenase HUT10_RS18115 ENOG4108Z86 Glutamine amidotransferase HUT10_RS18165 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT10_RS18175 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT10_RS18180 ENOG41084BZ 50S ribosomal protein L32 HUT10_RS18210 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT10_RS18215 ENOG4106H78 methyltransferase HUT10_RS18220 ENOG4105EEM helicase HUT10_RS18225 ENOG4108HMN Caspase domain HUT10_RS18230 ENOG4105DEN Luciferase family HUT10_RS18345 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT10_RS18375 ENOG4105DP4 dak2 domain fusion protein ylov HUT10_RS18380 ENOG4105VB9 50S ribosomal protein l28 HUT10_RS18390 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT10_RS18395 ENOG4108Z0R Transferase HUT10_RS18430 ENOG4105CPF Cell wall formation (By similarity) HUT10_RS18435 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT10_RS18445 ENOG4105BZU Histidine kinase HUT10_RS18450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT10_RS18490 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT10_RS18495 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS18525 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT10_RS18530 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT10_RS18570 ENOG4105EYH Exonuclease HUT10_RS18585 ENOG4105K70 DNA-binding protein HUT10_RS18675 ENOG4105ERH Fumarylacetoacetate hydrolase HUT10_RS18680 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT10_RS18685 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT10_RS18690 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT10_RS18730 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT10_RS18735 ENOG4108ZP8 Acetolactate synthase small subunit HUT10_RS18750 ENOG4105C01 Dihydroxy-acid dehydratase HUT10_RS18785 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT10_RS18790 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT10_RS18795 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT10_RS18810 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT10_RS18830 ENOG4105C5X domain protein HUT10_RS18850 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT10_RS18865 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS18885 ENOG4105C10 Electron transfer flavoprotein HUT10_RS18895 ENOG4105EPR degv family HUT10_RS18905 ENOG4108KQJ Type 11 methyltransferase HUT10_RS18915 ENOG4108V06 Glutathione peroxidase HUT10_RS18930 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HUT10_RS18950 ENOG4107R9S Malate synthase HUT10_RS18995 ENOG4105EVB acetyltransferase HUT10_RS19005 ENOG4105ZXU NLP P60 protein HUT10_RS19015 ENOG4105KVH Transcriptional regulator HUT10_RS19070 ENOG4108NNZ chitinase HUT10_RS19095 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS19100 ENOG4105UPE Enoyl-CoA hydratase HUT10_RS19105 ENOG4105DKW ABC transporter HUT10_RS19145 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUT10_RS19170 ENOG41067TZ transcriptional regulator, MarR family HUT10_RS19180 ENOG4105CWX Alpha-1,2-mannosidase HUT10_RS19185 ENOG4105CWX Alpha-1,2-mannosidase HUT10_RS19190 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS19200 ENOG4105C2J ABC transporter HUT10_RS19205 ENOG4105CNN ABC, transporter HUT10_RS19210 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT10_RS19220 ENOG4108HRK Histidine kinase HUT10_RS19225 ENOG4108NEV two component transcriptional regulator, LytTR family HUT10_RS19245 ENOG4107QN1 sodium solute HUT10_RS19250 ENOG4105CR4 methylisocitrate lyase HUT10_RS19255 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT10_RS19260 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT10_RS19275 ENOG4105CHU acetyl-coa acetyltransferase HUT10_RS19310 ENOG4108QER Adenylate cyclase HUT10_RS19320 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT10_RS19325 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT10_RS19330 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT10_RS19335 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT10_RS19340 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT10_RS19345 ENOG4105DXM phenylacetic acid degradation protein HUT10_RS19360 ENOG4108IG5 Transcriptional regulator HUT10_RS19385 ENOG4105F95 Monooxygenase HUT10_RS19400 ENOG4105BZM domain protein HUT10_RS19420 ENOG4105C1J atp-dependent rna helicase HUT10_RS19425 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT10_RS19450 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HUT10_RS19455 ENOG4105CHR reductase HUT10_RS19475 ENOG4105DKQ ROK family HUT10_RS19480 ENOG4107WCA isomerase HUT10_RS19490 ENOG4105F5H Glycosyl Hydrolase Family 88 HUT10_RS19495 ENOG4107MV2 Inherit from COG: Hemolysin-type calcium-binding HUT10_RS19505 ENOG4105DGI Alkaline phosphatase HUT10_RS19520 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HUT10_RS19535 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HUT10_RS19550 ENOG4105ESN nucleotide-binding protein HUT10_RS19555 ENOG4105ESN nucleotide-binding protein HUT10_RS19555 ENOG4105ESN nucleotide-binding protein HUT10_RS19570 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator HUT10_RS19575 ENOG4105C2J ABC transporter HUT10_RS19580 ENOG4105CNN ABC, transporter HUT10_RS19585 ENOG4105C6F GntR Family Transcriptional Regulator HUT10_RS19615 ENOG4108M15 ABC transporter HUT10_RS19635 ENOG4105WWK YheO domain protein HUT10_RS19640 ENOG4105CDA abc transporter atp-binding protein HUT10_RS19645 ENOG4108HW4 amino acid AbC transporter HUT10_RS19650 ENOG4108HW3 (ABC) transporter HUT10_RS19685 ENOG4105KVH Transcriptional regulator HUT10_RS19775 ENOG4105EBR Carboxylesterase HUT10_RS19790 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT10_RS19800 ENOG4105EGE secreted protein HUT10_RS19835 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT10_RS19910 ENOG4107QX8 SPFH domain, Band 7 family protein HUT10_RS19985 ENOG4105CHR reductase HUT10_RS19990 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT10_RS20015 ENOG4105ERH Fumarylacetoacetate hydrolase HUT10_RS20040 ENOG4108PVQ transcriptional regulator HUT10_RS20050 ENOG4105CV8 reductase HUT10_RS20055 ENOG4107SET aldo keto reductase HUT10_RS20100 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT10_RS20105 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT10_RS20110 ENOG4105C7W Xanthine dehydrogenase HUT10_RS20145 ENOG4105EMU Dehydrogenase HUT10_RS20160 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS20170 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS20185 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT10_RS20215 ENOG4105C57 major facilitator superfamily HUT10_RS20230 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS20235 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT10_RS20240 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS20250 ENOG4105C0D helicase HUT10_RS20255 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS20260 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS20285 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT10_RS20340 ENOG4105CJ1 ABC, transporter HUT10_RS20350 ENOG4107T94 Endo-14-beta-xylanase HUT10_RS20370 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT10_RS20400 ENOG4108IG5 Transcriptional regulator HUT10_RS20410 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT10_RS20420 ENOG4108IV0 ABC, transporter HUT10_RS20425 ENOG4105C0Z ABC transporter HUT10_RS20430 ENOG4105GVF (ABC) transporter HUT10_RS20435 ENOG4105E8G Major facilitator Superfamily HUT10_RS20460 ENOG4108XCU pts system HUT10_RS20465 ENOG4105F3R pts system mannose fructose sorbose family iid HUT10_RS20470 ENOG4105KPI PTS system sorbose subfamily IIB component HUT10_RS20480 ENOG4108ZT1 Transcriptional regulator HUT10_RS20485 ENOG4108KTG Membrane protein, drug metabolite transporter HUT10_RS20595 ENOG4105CIR epoxide hydrolase HUT10_RS20605 ENOG4105D82 Glutamate dehydrogenase HUT10_RS20615 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HUT10_RS20625 ENOG4105F8D glycoside hydrolase family 4 HUT10_RS20630 ENOG4108MGF sugar kinase HUT10_RS20635 ENOG4105K8R UPF0145 protein HUT10_RS20640 ENOG4105K8R UPF0145 protein HUT10_RS20655 ENOG4108RZE Tetr family transcriptional regulator HUT10_RS20665 ENOG4105CPT Alpha beta hydrolase HUT10_RS20675 ENOG4108R85 Short chain dehydrogenase HUT10_RS20690 ENOG4105CHR reductase HUT10_RS20700 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT10_RS20715 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HUT10_RS20750 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT10_RS20775 ENOG4105CHR reductase HUT10_RS20785 ENOG4105S7M extracellular small neutral protease HUT10_RS20790 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT10_RS20795 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS20800 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUT10_RS20805 ENOG4105C2J ABC transporter HUT10_RS20810 ENOG4107R9N ABC transporter HUT10_RS20815 ENOG41062B0 ABC transporter, permease HUT10_RS20830 ENOG4105FQP Beta-lactamase HUT10_RS20840 ENOG4108UZX fmn reductase HUT10_RS20855 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT10_RS20860 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT10_RS20870 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT10_RS20890 ENOG4105ZXU NLP P60 protein HUT10_RS20910 ENOG4107UBR Extracellular solute-binding protein family 3 HUT10_RS20915 ENOG4105CQ7 ATP-dependent helicase HUT10_RS20920 ENOG4105CJ1 ABC, transporter HUT10_RS20940 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS20945 ENOG4105BZU Histidine kinase HUT10_RS20975 ENOG4107IFA Lipase (EC 3.1.1.3) HUT10_RS20980 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT10_RS20995 ENOG4105CGP Urocanate hydratase HUT10_RS21000 ENOG4105C84 Histidine ammonia-lyase HUT10_RS21025 ENOG4105BZU Histidine kinase HUT10_RS21045 ENOG4105ENE Histidine kinase HUT10_RS21050 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS21070 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT10_RS21075 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HUT10_RS21080 ENOG4105CAK Cell division ATP-binding protein ftsE HUT10_RS21085 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT10_RS21115 ENOG4105DJZ UPF0182 protein HUT10_RS21160 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT10_RS21185 ENOG4105C5F glutamine synthetase HUT10_RS21195 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT10_RS21205 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT10_RS21235 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT10_RS21240 ENOG4105C5F glutamine synthetase HUT10_RS21260 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT10_RS21265 ENOG4105C4K Nad synthetase HUT10_RS21275 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT10_RS21295 ENOG4105CRK lysyL-tRNA synthetase HUT10_RS21300 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT10_RS21310 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT10_RS21315 ENOG4108HGY Proline imino-peptidase HUT10_RS21320 ENOG4108X07 Tetr family transcriptional regulator HUT10_RS21325 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HUT10_RS21330 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HUT10_RS21335 ENOG4105D81 ABC transporter, permease HUT10_RS21340 ENOG4107TYH extracellular solute-binding protein family 1 HUT10_RS21345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT10_RS21350 ENOG4105C26 Dehydrogenase HUT10_RS21390 ENOG4105C26 Dehydrogenase HUT10_RS21400 ENOG4105BZU Histidine kinase HUT10_RS21410 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT10_RS21520 ENOG4105EGD dinuclear metal center protein, YbgI family HUT10_RS21550 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUT10_RS21560 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT10_RS21565 ENOG4105C6Z Gluconate HUT10_RS21575 ENOG41082BM Transcriptional regulator, arsr family HUT10_RS21590 ENOG4105F8D glycoside hydrolase family 4 HUT10_RS21595 ENOG4105DRS transport system, permease HUT10_RS21600 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT10_RS21610 ENOG4105E2R ROK family HUT10_RS21620 ENOG4105C1V Peptidase, M16 HUT10_RS21640 ENOG4105CGZ zinc metallopeptidase HUT10_RS21660 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT10_RS21665 ENOG4108WQ6 secreted protein HUT10_RS21730 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT10_RS21755 ENOG4107QZF nitrite reductase NADPH large subunit HUT10_RS21760 ENOG4107QZF nitrite reductase NADPH large subunit HUT10_RS21765 ENOG4107QND Nitrite extrusion protein HUT10_RS21775 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT10_RS21800 ENOG4108R86 Transcriptional regulator HUT10_RS21805 ENOG410832A alpha/beta hydrolase fold HUT10_RS21825 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS21845 ENOG4105C1J atp-dependent rna helicase HUT10_RS21870 ENOG41081FY multiple antibiotic resistance (MarC)-related HUT10_RS21875 ENOG4105DB7 PHP domain protein HUT10_RS21905 ENOG4105D7N magnesium and cobalt transport protein CorA HUT10_RS21945 ENOG4105BZU Histidine kinase HUT10_RS21950 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS21960 ENOG4108SGK Tetr family transcriptional regulator HUT10_RS22000 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS22025 ENOG4105CJW magnesium transporter HUT10_RS22040 ENOG4105UTW Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT10_RS22045 ENOG4105C0H protease HUT10_RS22055 ENOG4105DU6 RNA polymerase HUT10_RS22060 ENOG4107ZBN O-methyltransferase HUT10_RS22065 ENOG4105D94 Major Facilitator Superfamily HUT10_RS22075 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT10_RS22085 ENOG4108UKI Enoyl-CoA hydratase HUT10_RS22090 ENOG4108R3E Dna-3-methyladenine glycosylase i HUT10_RS22115 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT10_RS22120 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT10_RS22125 ENOG4108JJ9 ABC, transporter HUT10_RS22130 ENOG4105BZ1 (ABC) transporter HUT10_RS22135 ENOG4105C3Q Glycosyl transferase, family 2 HUT10_RS22145 ENOG4108URH decarboxylase HUT10_RS22150 ENOG4108URH decarboxylase HUT10_RS22155 ENOG4105NTD Inherit from COG: Hydrolase HUT10_RS22160 ENOG410600Z Regulatory protein MarR HUT10_RS22250 ENOG4108Z4U Ferredoxin HUT10_RS22270 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT10_RS22285 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HUT10_RS22320 ENOG4105E2K Glycosyl transferase (Group 1 HUT10_RS22335 ENOG4108TJN glycosyl transferase group 1 HUT10_RS22345 ENOG4108SGK Tetr family transcriptional regulator HUT10_RS22360 ENOG4107TB5 TRANSCRIPTIONal HUT10_RS22365 ENOG4107TB5 TRANSCRIPTIONal HUT10_RS22405 ENOG4105ENX hydrolase HUT10_RS22420 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS22480 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS22485 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS22490 ENOG41065SU Two-component system sensor kinase HUT10_RS22500 ENOG4107TK4 histidinol-phosphate phosphatase HUT10_RS22515 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT10_RS22525 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HUT10_RS22530 ENOG4105K4H Nlp p60 protein HUT10_RS22545 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS22550 ENOG4105BZU Histidine kinase HUT10_RS22575 ENOG4108KPJ rna polymerase sigma factor HUT10_RS22580 ENOG4107QVI Methyltransferase, type 11 HUT10_RS22600 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS22610 ENOG4105ECQ AraC Family Transcriptional Regulator HUT10_RS22615 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT10_RS22620 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT10_RS22630 ENOG4105KVH Transcriptional regulator HUT10_RS22640 ENOG4108IG5 Transcriptional regulator HUT10_RS22645 ENOG4108WS4 fmn reductase HUT10_RS22660 ENOG4108ZGX Histidine kinase HUT10_RS22670 ENOG4105D8K carboxyl transferase HUT10_RS22680 ENOG4108V8F Transcriptional regulator, MarR family HUT10_RS22685 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT10_RS22705 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT10_RS22710 ENOG4107WR6 Maf-like protein HUT10_RS22715 ENOG4107QJT sodium dicarboxylate symporter HUT10_RS22730 ENOG4108JIK carboxylase HUT10_RS22750 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT10_RS22755 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT10_RS22760 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT10_RS22800 ENOG4107RM1 amidohydrolase HUT10_RS22825 ENOG4107TPY serine threonine protein kinase HUT10_RS22855 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT10_RS22880 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT10_RS22895 ENOG41062D9 Histidine kinase HUT10_RS22900 ENOG4105ETX regulatoR HUT10_RS22925 ENOG4105CPC Aldo Keto reductase HUT10_RS22930 ENOG4108Z4X TRANSCRIPTIONal HUT10_RS22945 ENOG4105WH9 RNA polymerase HUT10_RS22965 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUT10_RS22970 ENOG4105C26 Dehydrogenase HUT10_RS22975 ENOG4105C26 Dehydrogenase HUT10_RS23035 ENOG4105CPQ Dehydrogenase HUT10_RS23065 ENOG4105KVH Transcriptional regulator HUT10_RS23090 ENOG4105E5T Major Facilitator Superfamily HUT10_RS23095 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT10_RS23125 ENOG4108JQ9 ABC transporter HUT10_RS23130 ENOG4105DIH basic membrane HUT10_RS23135 ENOG4105EX0 alpha-galactosidase HUT10_RS23155 ENOG4105E33 succinate dehydrogenase HUT10_RS23175 ENOG4107H3J ribonuclease HUT10_RS23185 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT10_RS23235 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT10_RS23265 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS23270 ENOG4108RWP Major Facilitator Superfamily protein HUT10_RS23275 ENOG4105YVS arsR family transcriptional regulator HUT10_RS23280 ENOG4105F27 Major Facilitator HUT10_RS23290 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT10_RS23315 ENOG4105C0B DNA polymerase III (alpha subunit) HUT10_RS23345 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT10_RS23370 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT10_RS23385 ENOG4108K5P (LipO)protein HUT10_RS23390 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS23425 ENOG4105D9P serine threonine protein kinase HUT10_RS23430 ENOG4107QPV Serine Threonine protein kinase HUT10_RS23435 ENOG4107RSM transcriptional regulator HUT10_RS23465 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT10_RS23485 ENOG4105DNP FAD linked oxidase domain protein HUT10_RS23505 ENOG4107QVP Dehydrogenase HUT10_RS23560 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT10_RS23570 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT10_RS23575 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT10_RS23610 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT10_RS23615 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HUT10_RS23625 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS23630 ENOG4105D8K carboxyl transferase HUT10_RS23640 ENOG4108097 ATP-binding protein HUT10_RS23645 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT10_RS23650 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT10_RS23665 ENOG4107EDW L-fucose operon activator HUT10_RS23705 ENOG4107RCI amp-dependent synthetase and ligase HUT10_RS23715 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT10_RS23720 ENOG4108UJD 30S ribosomal protein S9 HUT10_RS23725 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT10_RS23755 ENOG4105CFG Acts as a chaperone (By similarity) HUT10_RS23760 ENOG4105EC2 ftsk spoIIIe HUT10_RS23770 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin HUT10_RS23805 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT10_RS23810 ENOG4108ZT0 50S ribosomal protein l17 HUT10_RS23815 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT10_RS23820 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT10_RS23825 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT10_RS23835 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT10_RS23840 ENOG41067V7 50S ribosomal protein L36 HUT10_RS23855 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT10_RS23865 ENOG410829K Lysine exporter protein (Lyse ygga) HUT10_RS23875 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT10_RS23880 ENOG410849U 50S ribosomal protein L30 HUT10_RS23885 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT10_RS23890 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT10_RS23895 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT10_RS23900 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT10_RS23905 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT10_RS23910 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT10_RS23915 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT10_RS23920 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT10_RS23925 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT10_RS23930 ENOG41082SA 50s ribosomal protein l29 HUT10_RS23935 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT10_RS23940 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT10_RS23945 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT10_RS23950 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT10_RS23955 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT10_RS23960 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT10_RS23965 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT10_RS23970 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT10_RS23980 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT10_RS23985 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT10_RS23990 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT10_RS23995 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT10_RS24060 ENOG4108UQS dipeptidase HUT10_RS24070 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT10_RS24085 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT10_RS24105 ENOG4107QVI Methyltransferase, type 11 HUT10_RS24110 ENOG4105Q56 cytochrome P450 HUT10_RS24125 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HUT10_RS24150 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT10_RS24155 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HUT10_RS24170 ENOG4105Q56 cytochrome P450 HUT10_RS24175 ENOG4106YKD Cytochrome p-450 HUT10_RS24195 ENOG4105C57 major facilitator superfamily HUT10_RS24205 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT10_RS24215 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT10_RS24230 ENOG4107S9B Shikimate dehydrogenase HUT10_RS24235 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT10_RS24240 ENOG4105D49 3-dehydroquinate synthase HUT10_RS24300 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT10_RS24360 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUT10_RS24365 ENOG4108VZM 50s ribosomal protein L10 HUT10_RS24380 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT10_RS24385 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT10_RS24410 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT10_RS24430 ENOG410900P UPF0336 protein HUT10_RS24435 ENOG4105WDJ 50S ribosomal protein L33 HUT10_RS24450 ENOG4105BZU Histidine kinase HUT10_RS24470 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT10_RS24480 ENOG4108VPT UPF0234 protein HUT10_RS24505 ENOG4105DYW oxidoreductase HUT10_RS24520 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HUT10_RS24530 ENOG4105CMR udp-glucose 4-epimerase HUT10_RS24535 ENOG4105EQQ protein containing aminopeptidase domain HUT10_RS24555 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HUT10_RS24560 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT10_RS24600 ENOG4107RRD Dehydrogenase HUT10_RS24605 ENOG4105CAQ asparagine synthetase HUT10_RS24625 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT10_RS24640 ENOG4105CIK Amidinotransferase HUT10_RS24645 ENOG4108VVK transcriptional Regulator, AsnC HUT10_RS24665 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT10_RS24670 ENOG4105DQU oxidoreductase, subunit beta HUT10_RS24715 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT10_RS24725 ENOG4105D65 subunit l HUT10_RS24730 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT10_RS24735 ENOG41087XN oxidoreductase HUT10_RS24740 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT10_RS24745 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT10_RS24750 ENOG4108IEH NADH dehydrogenase subunit g HUT10_RS24755 ENOG4107QIZ NADH dehydrogenase HUT10_RS24765 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT10_RS24770 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT10_RS24775 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT10_RS24790 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS24795 ENOG4108MJN Glycosyl Transferase HUT10_RS24805 ENOG4105ECY inositol monophosphatase HUT10_RS24820 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HUT10_RS24825 ENOG4107SIQ Naphthoate synthase HUT10_RS24855 ENOG4105F7P transcriptional regulator AsnC family HUT10_RS24875 ENOG4105CRE cytochrome C HUT10_RS24885 ENOG4107QIV Cytochrome c biogenesis protein HUT10_RS24900 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUT10_RS24905 ENOG4108RH7 phosphoglycerate mutase HUT10_RS24910 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT10_RS24925 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT10_RS24930 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT10_RS24935 ENOG4105DJY efflux transporter, rnd family, mfp subunit HUT10_RS24965 ENOG4105CMR udp-glucose 4-epimerase HUT10_RS24970 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT10_RS24975 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT10_RS24980 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT10_RS24985 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT10_RS25000 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS25045 ENOG4105II7 pyrroline-5-carboxylate reductase HUT10_RS25060 ENOG41063NU Membrane HUT10_RS25075 ENOG4105BZU Histidine kinase HUT10_RS25080 ENOG4107S5I aldo keto reductase HUT10_RS25095 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT10_RS25105 ENOG4108YZJ Pfam:DUF2596 HUT10_RS25110 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT10_RS25125 ENOG4107R4N Cell wall formation (By similarity) HUT10_RS25155 ENOG4105DQ4 alcohol dehydrogenase HUT10_RS25160 ENOG41067SE Tetr family transcriptional regulator HUT10_RS25170 ENOG4105YVS arsR family transcriptional regulator HUT10_RS25180 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT10_RS25235 ENOG4105R40 Glycine betaine carnitine choline HUT10_RS25255 ENOG4105C84 Histidine ammonia-lyase HUT10_RS25275 ENOG4105V9F hemagglutinin HUT10_RS25285 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT10_RS25290 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUT10_RS25310 ENOG4106BRA Membrane HUT10_RS25325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT10_RS25330 ENOG4108VW9 Membrane HUT10_RS25355 ENOG4105K6H D-cysteine desulfhydrase HUT10_RS25445 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUT10_RS25470 ENOG4107HP6 Transcriptional regulator HUT10_RS25490 ENOG4105C2W permease HUT10_RS25515 ENOG4105BZU Histidine kinase HUT10_RS25520 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HUT10_RS25535 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS25590 ENOG4105FDP GntR family transcriptional regulator HUT10_RS25635 ENOG4105VEQ Cold shock protein HUT10_RS25650 ENOG4105NAF rna polymerase sigma factor HUT10_RS25660 ENOG4105CSH Transporter HUT10_RS25670 ENOG4107Q25 Serine Threonine protein kinase HUT10_RS25675 ENOG4105CT1 (ABC) transporter HUT10_RS25685 ENOG4107RR1 TRANSCRIPTIONal HUT10_RS25690 ENOG4107R0V Pyruvate dehydrogenase HUT10_RS25695 ENOG4106Z86 ATP-nad acox kinase HUT10_RS25730 ENOG4105CJA serine threonine protein kinase HUT10_RS25790 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT10_RS25805 ENOG4105DBV ornithine carbamoyltransferase HUT10_RS25820 ENOG4105K56 Transcriptional regulator HUT10_RS25840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT10_RS25845 ENOG4105EVN Prephenate dehydrogenase HUT10_RS25900 ENOG4105CIG ABC transporter HUT10_RS25905 ENOG4105DIM ABC transporter HUT10_RS25945 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT10_RS25970 ENOG4105CPC Aldo Keto reductase HUT10_RS25980 ENOG41069ER domain protein HUT10_RS26015 ENOG4106UDK Cellulose-binding, family II HUT10_RS26045 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT10_RS26055 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT10_RS26085 ENOG41073TP transcriptional regulator HUT10_RS26105 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT10_RS26115 ENOG4105KF0 sporulation and cell division protein, SsgA HUT10_RS26120 ENOG4106T9R serine protease HUT10_RS26125 ENOG4107SM8 Adenylate Guanylate cyclase HUT10_RS26155 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT10_RS26160 ENOG4108MRH transcriptional regulatory protein HUT10_RS26220 ENOG4105IIU Aminopeptidase HUT10_RS26225 ENOG4105CPQ Dehydrogenase HUT10_RS26235 ENOG4108VC7 Protein of unknown function (DUF2587) HUT10_RS26250 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HUT10_RS26255 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase HUT10_RS26260 ENOG4105D2T synthase HUT10_RS26275 ENOG4108MKI Glycosyl transferase, family 2 HUT10_RS26305 ENOG410602S Transferase HUT10_RS26315 ENOG4105IQ5 FAD linked oxidase domain protein HUT10_RS26320 ENOG4108RG3 short-chain dehydrogenase reductase HUT10_RS26335 ENOG4106YN8 Prenyltransferase HUT10_RS26355 ENOG4105DYW oxidoreductase HUT10_RS26360 ENOG4108KP7 hydrolase HUT10_RS26400 ENOG4105CHR reductase HUT10_RS26410 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HUT10_RS26450 ENOG4105JNK Glycosyl transferase (Group 1 HUT10_RS26460 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT10_RS26480 ENOG4105D5U fad dependent oxidoreductase HUT10_RS26490 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT10_RS26495 ENOG4105C8Y Acetylornithine aminotransferase HUT10_RS26505 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT10_RS26510 ENOG4108J2P Alpha beta hydrolase fold HUT10_RS26520 ENOG4106032 Glutathionylspermidine synthase HUT10_RS26555 ENOG4108RH7 phosphoglycerate mutase HUT10_RS26565 ENOG4108UVJ appr-1-p processing domain protein HUT10_RS26570 ENOG4105CS9 pantothenic acid kinase HUT10_RS26585 ENOG4105KBK Zinc finger, swim domain protein HUT10_RS26650 ENOG4108JJ9 ABC, transporter HUT10_RS26655 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT10_RS26660 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT10_RS26700 ENOG4108HMN Caspase domain HUT10_RS26740 ENOG4105CEU Arginine dihydrolase HUT10_RS26775 ENOG4105T1M mycothiol conjugate amidase mca HUT10_RS26780 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS26800 ENOG4107QN1 sodium solute HUT10_RS26825 ENOG4108HRK Histidine kinase HUT10_RS26900 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS26905 ENOG4105BZU Histidine kinase HUT10_RS26950 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT10_RS26960 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS26980 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HUT10_RS26985 ENOG4105E90 ABC transporter HUT10_RS26990 ENOG4108IJ8 ABC transporter HUT10_RS26995 ENOG4105E90 ABC transporter HUT10_RS27010 ENOG4108T5E Copper resistance protein HUT10_RS27050 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT10_RS27070 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT10_RS27085 ENOG4105CI0 Citrate lyase HUT10_RS27105 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT10_RS27110 ENOG4108JQ7 (ABC) transporter HUT10_RS27115 ENOG4105C3U ABC transporter HUT10_RS27120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT10_RS27130 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT10_RS27135 ENOG4108QBF Transcriptional regulator HUT10_RS27165 ENOG4105C28 cystathionine HUT10_RS27195 ENOG4105TV9 FHA Domain-Containing protein HUT10_RS27200 ENOG4105HZM Fha domain containing protein HUT10_RS27215 ENOG4105CJN penicillin-binding protein HUT10_RS27220 ENOG4107TPY serine threonine protein kinase HUT10_RS27225 ENOG4105D9P serine threonine protein kinase HUT10_RS27240 ENOG4105CIG ABC transporter HUT10_RS27255 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS27290 ENOG4108U4N (sortase) family HUT10_RS27305 ENOG4107ZXI Rhomboid family HUT10_RS27345 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT10_RS27400 ENOG41082BM Transcriptional regulator, arsr family HUT10_RS27435 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT10_RS27445 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT10_RS27450 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT10_RS27455 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT10_RS27460 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HUT10_RS27470 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HUT10_RS27475 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT10_RS27480 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT10_RS27490 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT10_RS27495 ENOG4107QJE Chromosome Partitioning Protein HUT10_RS27505 ENOG4105CPF Cell wall formation (By similarity) HUT10_RS27520 ENOG4108E1C hydrolase HUT10_RS27525 ENOG4105C3M thioredoxin reductase HUT10_RS27530 ENOG4105C3M thioredoxin reductase HUT10_RS27570 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUT10_RS27595 ENOG41065RQ ADP-ribosylation crystallin J1 HUT10_RS27650 ENOG4105C8T Leucyl-tRNA synthetase HUT10_RS27655 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT10_RS27710 ENOG4108RVA ribokinase HUT10_RS27720 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT10_RS27725 ENOG4105C57 major facilitator superfamily HUT10_RS27740 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS27765 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUT10_RS27805 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT10_RS27810 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT10_RS27820 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT10_RS27850 ENOG4105E2R ROK family HUT10_RS27855 ENOG4105D9R oxidoreductase HUT10_RS27860 ENOG4105BZ4 penicillin-binding protein HUT10_RS27865 ENOG4105BZ4 penicillin-binding protein HUT10_RS27885 ENOG4105NAF rna polymerase sigma factor HUT10_RS27895 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HUT10_RS27900 ENOG41067TZ transcriptional regulator, MarR family HUT10_RS27905 ENOG4105DXB Major Facilitator superfamily HUT10_RS27915 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein HUT10_RS27920 ENOG4105EMU Dehydrogenase HUT10_RS27925 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT10_RS27930 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS27940 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT10_RS27950 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUT10_RS27965 ENOG4105CJ1 ABC, transporter HUT10_RS27985 ENOG4105CHR reductase HUT10_RS27990 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS27995 ENOG4105BZU Histidine kinase HUT10_RS28020 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT10_RS28035 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT10_RS28050 ENOG4108WUZ (ABC) transporter HUT10_RS28120 ENOG4105CHU acetyl-coa acetyltransferase HUT10_RS28125 ENOG4105CHR reductase HUT10_RS28130 ENOG4108F01 MaoC domain protein HUT10_RS28135 ENOG4108R86 Transcriptional regulator HUT10_RS28170 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HUT10_RS28195 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT10_RS28200 ENOG4105CPP Dehydrogenase, E1 component HUT10_RS28210 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT10_RS28270 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT10_RS28300 ENOG4105CSU acyl-Coa dehydrogenase HUT10_RS28305 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS28310 ENOG4108VCA G U mismatch-specific DNA glycosylase HUT10_RS28335 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT10_RS28340 ENOG4107T31 5'-nucleotidase HUT10_RS28350 ENOG4108MK9 spermidine N(1)-acetyltransferase HUT10_RS28365 ENOG4105GRZ Ycii-related protein HUT10_RS28370 ENOG4105CHP RNA polymerase HUT10_RS28385 ENOG4105CB5 ATP-dependent DNA helicase recG HUT10_RS28390 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT10_RS28455 ENOG41061H0 Monooxygenase HUT10_RS28470 ENOG4105K4I Scp-like extracellular HUT10_RS28485 ENOG4105DF6 Fe-S oxidoreductase HUT10_RS28530 ENOG4105CFG Acts as a chaperone (By similarity) HUT10_RS28535 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT10_RS28540 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT10_RS28545 ENOG4105KNI merR family transcriptional Regulator HUT10_RS28565 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT10_RS28585 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT10_RS28605 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT10_RS28620 ENOG4105EMN RNA polymerase sigma factor HUT10_RS28640 ENOG4105VBF alkaline shock protein HUT10_RS28650 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT10_RS28660 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT10_RS28675 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS28685 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator HUT10_RS28690 ENOG4105CNN ABC, transporter HUT10_RS28695 ENOG4105C2J ABC transporter HUT10_RS28700 ENOG4108MGF sugar kinase HUT10_RS28705 ENOG4105DBI uridine monophosphokinase HUT10_RS28710 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT10_RS28725 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT10_RS28735 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS28745 ENOG410905P Pyridoxamine 5-phosphate HUT10_RS28750 ENOG4105CQB FAD linked oxidase domain protein HUT10_RS28755 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT10_RS28765 ENOG4105CE4 GlcNAc 6-P deacetylase HUT10_RS28790 ENOG4107RN6 Monooxygenase HUT10_RS28800 ENOG4105CHR reductase HUT10_RS28805 ENOG4105CPC Aldo Keto reductase HUT10_RS28860 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT10_RS28890 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT10_RS28905 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT10_RS28910 ENOG4105EEQ Na H antiporter HUT10_RS28915 ENOG4105D2S major facilitator superfamily HUT10_RS28930 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HUT10_RS29035 ENOG4105CXK mandelate racemase muconate lactonizing HUT10_RS29040 ENOG4105C83 adenylosuccinate lyase HUT10_RS29050 ENOG4105EAB amino acid AbC transporter HUT10_RS29060 ENOG4105EAD ABC transporter HUT10_RS29065 ENOG4105CDA abc transporter atp-binding protein HUT10_RS29080 ENOG4105C8V SAICAR synthetase HUT10_RS29130 ENOG410839H phosphoribosylformylglycinamidine synthase HUT10_RS29135 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT10_RS29145 ENOG4105BZ1 (ABC) transporter HUT10_RS29155 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT10_RS29165 ENOG4105BZU Histidine kinase HUT10_RS29230 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT10_RS29235 ENOG4108YZN class I peptide chain release factor HUT10_RS29265 ENOG4105BZ1 (ABC) transporter HUT10_RS29285 ENOG4108TAC HUT10_RS29315 ENOG4107R7A Allophanate hydrolase subunit 2 HUT10_RS29320 ENOG4105P4J Allophanate hydrolase, subunit 1 HUT10_RS29325 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT10_RS29330 ENOG4105PKJ carbohydrate binding HUT10_RS29335 ENOG4105KHC sulfurtransferase HUT10_RS29355 ENOG4107NHD transcriptional regulator HUT10_RS29360 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT10_RS29365 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HUT10_RS29380 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT10_RS29390 ENOG4108KGH TRANSCRIPTIONal HUT10_RS29395 ENOG4105BZU Histidine kinase HUT10_RS29400 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT10_RS29405 ENOG4105D74 hydrolase HUT10_RS29425 ENOG4108RVA ribokinase HUT10_RS29430 ENOG4108KD5 ADP-ribosylation crystallin J1 HUT10_RS29435 ENOG4105FDP GntR family transcriptional regulator HUT10_RS29455 ENOG4108UVJ appr-1-p processing domain protein HUT10_RS29460 ENOG4105EE0 oxidoreductase HUT10_RS29495 ENOG4105EEM helicase HUT10_RS29505 ENOG4105CUB amino acid HUT10_RS29520 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT10_RS29525 ENOG4105DRR Transcriptional regulator, GntR family HUT10_RS29540 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT10_RS29550 ENOG4108Z6Z Transcriptional regulator HUT10_RS29560 ENOG41090KN UPF0303 protein HUT10_RS29585 ENOG4108Z6B deaminase HUT10_RS29620 ENOG4105MXB limonene-12-epoxide hydrolase HUT10_RS29665 ENOG4105EC2 ftsk spoIIIe HUT10_RS29710 ENOG4107YB1 Trehalose corynomycolyl transferase HUT10_RS29720 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT10_RS29740 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS29755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT10_RS29760 ENOG4105BZU Histidine kinase HUT10_RS29765 ENOG4105EDW glycosyl transferase, family 39 HUT10_RS29775 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT10_RS29835 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT10_RS29840 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HUT10_RS29850 ENOG4105CND Glycosyl transferase, family 2 HUT10_RS29870 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT10_RS29885 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT10_RS29890 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT10_RS29895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT10_RS29900 ENOG4105C3U ABC transporter HUT10_RS29905 ENOG4108JQ7 (ABC) transporter HUT10_RS29910 ENOG4105CHP RNA polymerase HUT10_RS29915 ENOG4105GRZ Ycii-related protein HUT10_RS29935 ENOG4108594 Permease of the drug metabolite transporter HUT10_RS29940 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS29985 ENOG4105CFH Aspartokinase HUT10_RS29995 ENOG4105E0Y RtcB Protein HUT10_RS30010 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS30035 ENOG4108ZHJ Organic hydroperoxide resistance protein HUT10_RS30040 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT10_RS30045 ENOG4105CVK Glutamate decarboxylase HUT10_RS30055 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT10_RS30085 ENOG4105DIN metallophosphoesterase HUT10_RS30095 ENOG4108JQC penicillin-binding protein 1A HUT10_RS30145 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT10_RS30160 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT10_RS30210 ENOG4105D74 hydrolase HUT10_RS30220 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT10_RS30225 ENOG4105DUX Transporter HUT10_RS30250 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT10_RS30260 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HUT10_RS30270 ENOG4105YVS arsR family transcriptional regulator HUT10_RS30275 ENOG4108SUT Major Facilitator Superfamily HUT10_RS30280 ENOG4105D9G High-affinity HUT10_RS30285 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT10_RS30290 ENOG4106KNT transcriptional regulator HUT10_RS30295 ENOG4107S1E Beta-lactamase HUT10_RS30300 ENOG4105EHZ conserved protein UCP016719 HUT10_RS30305 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT10_RS30360 ENOG4108I5C dEAD DEAH box helicase HUT10_RS30365 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT10_RS30385 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT10_RS30415 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT10_RS30420 ENOG4105C6E dna polymerase iii HUT10_RS30495 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT10_RS30500 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT10_RS30505 ENOG4105ECY inositol monophosphatase HUT10_RS30520 ENOG4105F0N pyrophosphate phospho-hydrolase HUT10_RS30535 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT10_RS30565 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT10_RS30570 ENOG4105EUJ GTP cyclohydrolase i HUT10_RS30575 ENOG4105EEI dihydropteroate synthase HUT10_RS30590 ENOG4105W1Y Transcriptional regulator HUT10_RS30615 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT10_RS30620 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT10_RS30625 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT10_RS30640 ENOG4105CRK lysyL-tRNA synthetase HUT10_RS30670 ENOG4105CFG Acts as a chaperone (By similarity) HUT10_RS30695 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HUT10_RS30735 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HUT10_RS30760 ENOG4105CEN a g-specific adenine glycosylase HUT10_RS30780 ENOG4105DSE periplasmic solute binding protein HUT10_RS30785 ENOG4105E0A ABC, transporter HUT10_RS30790 ENOG4105CC5 ABC transporter HUT10_RS30800 ENOG4106MP8 UPF0754 membrane protein HUT10_RS30815 ENOG4107W7X Aldolase HUT10_RS30850 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HUT10_RS30860 ENOG4105C8N cysteinyl-tRNA synthetase HUT10_RS30875 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT10_RS30880 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT10_RS30885 ENOG4108VJ1 Transcriptional regulator (CarD family HUT10_RS30890 ENOG41062GB lipoprotein lpqE HUT10_RS30895 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HUT10_RS30905 ENOG4105I6B RNA polymerase HUT10_RS30935 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT10_RS30970 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT10_RS31005 ENOG4105VUF Transcriptional regulator HUT10_RS31020 ENOG4105EGE secreted protein HUT10_RS31040 ENOG4108KPJ rna polymerase sigma factor HUT10_RS31080 ENOG4105GR3 Histidine kinase HUT10_RS31100 ENOG4105GRZ Ycii-related protein HUT10_RS31105 ENOG4105GRZ Ycii-related protein HUT10_RS31110 ENOG4105CHP RNA polymerase HUT10_RS31115 ENOG4105DK2 UPF0207 protein HUT10_RS31120 ENOG4105DAA L-lactate HUT10_RS31140 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT10_RS31145 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT10_RS31155 ENOG4105ETX regulatoR HUT10_RS31175 ENOG4107ETC gas vesicle protein HUT10_RS31180 ENOG4108XNA Gas vesicle HUT10_RS31185 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth HUT10_RS31200 ENOG4105K4P CoA-binding domain protein HUT10_RS31225 ENOG4105BZ1 (ABC) transporter HUT10_RS31260 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT10_RS31310 ENOG41060H3 Protein of unknown function (DUF1049) HUT10_RS31325 ENOG4106MP8 UPF0754 membrane protein HUT10_RS31355 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HUT10_RS31360 ENOG4105EV8 ectoine hydroxylase HUT10_RS31395 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HUT10_RS31405 ENOG4105RD7 BadF BadG BcrA BcrD HUT10_RS31410 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT10_RS31415 ENOG4105FDP GntR family transcriptional regulator HUT10_RS31420 ENOG4105C57 major facilitator superfamily HUT10_RS31425 ENOG4105C7B Threonine dehydratase HUT10_RS31435 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT10_RS31450 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT10_RS31475 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT10_RS31480 ENOG4105KVH Transcriptional regulator HUT10_RS31495 ENOG4105DWF phosphomethylpyrimidine kinase HUT10_RS31500 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT10_RS31515 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT10_RS31540 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUT10_RS31550 ENOG4105Y3U Transglycosylase-associated protein HUT10_RS31580 ENOG4105VEQ Cold shock protein HUT10_RS31595 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT10_RS31615 ENOG4107TCW O-succinylbenzoate synthase HUT10_RS31640 ENOG4105CFI type iii restriction protein res subunit HUT10_RS31695 ENOG4105D7T ABC transporter HUT10_RS31700 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT10_RS31715 ENOG4105DHQ Histidine kinase HUT10_RS31720 ENOG4105GWZ Roadblock lc7 family protein HUT10_RS31735 ENOG4105GWZ Roadblock lc7 family protein HUT10_RS31790 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT10_RS31830 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HUT10_RS31835 ENOG410901E Membrane HUT10_RS31840 ENOG4107TIF Phenazine biosynthesis protein, PhzF family HUT10_RS31865 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUT10_RS31885 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT10_RS31900 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS31910 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta HUT10_RS31920 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT10_RS31930 ENOG4105VEQ Cold shock protein HUT10_RS31940 ENOG4108N0W Major Facilitator superfamily HUT10_RS31965 ENOG4105C7N Xanthine uracil vitamin C permease HUT10_RS31980 ENOG4107SFI Major Facilitator superfamily HUT10_RS31985 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HUT10_RS32010 ENOG4105FCS tRNA rRNA methyltransferase HUT10_RS32030 ENOG4106F60 Histidine kinase HUT10_RS32035 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT10_RS32050 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT10_RS32055 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT10_RS32060 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT10_RS32065 ENOG4108VJY integral membrane protein HUT10_RS32070 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT10_RS32085 ENOG4105ED2 Beta-lactamase HUT10_RS32090 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS32105 ENOG4105CJ1 ABC, transporter HUT10_RS32125 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUT10_RS32130 ENOG4105KI2 Urea amidohydrolase subunit beta HUT10_RS32135 ENOG4105CQM Urea amidohydrolase subunit alpha HUT10_RS32145 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUT10_RS32150 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HUT10_RS32170 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT10_RS32195 ENOG4105J7D transcriptional regulator HUT10_RS32200 ENOG4107WI4 Aldose-1-epimerase HUT10_RS32210 ENOG4105CPN adenine deaminase HUT10_RS32225 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS32245 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT10_RS32255 ENOG4108IUX (ABC) transporter HUT10_RS32280 ENOG4105CQB FAD linked oxidase domain protein HUT10_RS32300 ENOG4108KPJ rna polymerase sigma factor HUT10_RS32330 ENOG4105DRS transport system, permease HUT10_RS32340 ENOG4107FKK extracellular solute-binding protein family 1 HUT10_RS32355 ENOG4105E4F Isochorismate synthase HUT10_RS32390 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS32395 ENOG4105E39 Enoyl-CoA hydratase HUT10_RS32415 ENOG4105KST dependent repressor HUT10_RS32435 ENOG4105CF1 Alkylated DNA repair protein HUT10_RS32450 ENOG4107R7A Allophanate hydrolase subunit 2 HUT10_RS32465 ENOG4105CFM UPF0317 protein HUT10_RS32480 ENOG4106UDK Cellulose-binding, family II HUT10_RS32510 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT10_RS32520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT10_RS32525 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT10_RS32545 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS32590 ENOG4105EXC Acyl-transferase HUT10_RS32600 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS32610 ENOG4105DQE DNA ligase HUT10_RS32630 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT10_RS32645 ENOG4107QJN gtp cyclohydrolase ii HUT10_RS32655 ENOG4105ECY inositol monophosphatase HUT10_RS32660 ENOG4105D9P serine threonine protein kinase HUT10_RS32665 ENOG4105CPK Glycosyl transferase (Group 1 HUT10_RS32690 ENOG4105CPC Aldo Keto reductase HUT10_RS32695 ENOG4105DUM transcriptional regulator, lysR family HUT10_RS32700 ENOG4105C57 major facilitator superfamily HUT10_RS32745 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS32750 ENOG4107ZT3 family UPF0126 HUT10_RS32770 ENOG4105E98 transcriptional regulator DeoR family HUT10_RS32820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT10_RS32825 ENOG4105BZU Histidine kinase HUT10_RS32830 ENOG4105CMR udp-glucose 4-epimerase HUT10_RS32835 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT10_RS32865 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT10_RS32870 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT10_RS32880 ENOG4105D9U N-acetyltransferase HUT10_RS32925 ENOG4105C4R Atp-dependent dna helicase HUT10_RS32980 ENOG4105CPF Cell wall formation (By similarity) HUT10_RS32985 ENOG4108UQS dipeptidase HUT10_RS32990 ENOG4106F60 Histidine kinase HUT10_RS32995 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT10_RS33010 ENOG4105CE9 30S ribosomal protein S2 HUT10_RS33020 ENOG4105JZI cytochrome P450 HUT10_RS33030 ENOG4107RT3 EamA-like transporter family HUT10_RS33070 ENOG4108KPJ rna polymerase sigma factor HUT10_RS33080 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HUT10_RS33095 ENOG4108RPX mosc domain containing protein HUT10_RS33120 ENOG4105E2D ec 3.2.1.52 HUT10_RS33125 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT10_RS33130 ENOG4107TPY serine threonine protein kinase HUT10_RS33135 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT10_RS33165 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT10_RS33170 ENOG4105CRQ synthase (Component I) HUT10_RS33195 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT10_RS33200 ENOG4105F8V Hydrolase, tatD family HUT10_RS33210 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT10_RS33215 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT10_RS33220 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT10_RS33225 ENOG4105C5H ABC transporter HUT10_RS33230 ENOG4107RCI amp-dependent synthetase and ligase HUT10_RS33240 ENOG4107VQS DivIVA family HUT10_RS33245 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT10_RS33250 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT10_RS33275 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT10_RS33305 ENOG4108Z4K mutator MutT protein HUT10_RS33310 ENOG4105M6F mutator MutT protein HUT10_RS33335 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS33340 ENOG4105BZU Histidine kinase HUT10_RS33350 ENOG4108K81 inner membrane protein YghB HUT10_RS33420 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT10_RS33440 ENOG4105DBE peroxidase HUT10_RS33470 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT10_RS33495 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT10_RS33500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT10_RS33505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT10_RS33510 ENOG4105C3U ABC transporter HUT10_RS33515 ENOG4108JQ7 (ABC) transporter HUT10_RS33545 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT10_RS33560 ENOG4108NNZ chitinase HUT10_RS33600 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HUT10_RS33620 ENOG4105BZU Histidine kinase HUT10_RS33710 ENOG4105BZ1 (ABC) transporter HUT10_RS33720 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT10_RS33725 ENOG4106F60 Histidine kinase HUT10_RS33740 ENOG41065HY 1,4-beta-cellobiosidase HUT10_RS33760 ENOG4106T9R serine protease HUT10_RS33800 ENOG4107S5I aldo keto reductase HUT10_RS33810 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS33900 ENOG4105CUC YeeE YedE family protein HUT10_RS33905 ENOG4105CHU acetyl-coa acetyltransferase HUT10_RS33950 ENOG4105C7B Threonine dehydratase HUT10_RS33980 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT10_RS33985 ENOG4105EW9 transcriptional regulator AsnC family HUT10_RS33995 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT10_RS34005 ENOG4105T1M mycothiol conjugate amidase mca HUT10_RS34015 ENOG4107S1Q Phosphatase HUT10_RS34020 ENOG4105DXX methyltransferase HUT10_RS34030 ENOG4105C7Z Conserved Protein HUT10_RS34045 ENOG4105DDI hemolysin-type calcium-binding region HUT10_RS34055 ENOG4107KM7 Heat induced stress protein YflT HUT10_RS34080 ENOG4108IAB Phoh family HUT10_RS34100 ENOG4107VMB Beta-lactamase domain protein HUT10_RS34125 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) HUT10_RS34135 ENOG4105C9Q fumarate hydratase class II HUT10_RS34140 ENOG4108QB1 triacylglycerol lipase EC 3.1.1.3 HUT10_RS34150 ENOG4105CAY ferredoxin--nadp reductase HUT10_RS34165 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT10_RS34175 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT10_RS34185 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT10_RS34210 ENOG4105EYH Exonuclease HUT10_RS34225 ENOG4105C3G gtp-binding protein HUT10_RS34265 ENOG4105KZX Pterin carbinolamine dehydratase HUT10_RS34280 ENOG4108UCS ABC, transporter HUT10_RS34295 ENOG4105CJ1 ABC, transporter HUT10_RS34305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT10_RS34310 ENOG4105JJR Histidine kinase HUT10_RS34320 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT10_RS34335 ENOG4105CI3 gtp-binding protein typa HUT10_RS34340 ENOG4107USK Extracellular solute-binding protein, family 5 HUT10_RS34350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT10_RS34365 ENOG4105KVH Transcriptional regulator HUT10_RS34370 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HUT10_RS34380 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT10_RS34405 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT10_RS34425 ENOG4107QKV phosphomannomutase HUT10_RS34430 ENOG4105W49 UPF0434 protein HUT10_RS34440 ENOG4105EIP mannose-6-phosphate isomerase HUT10_RS34455 ENOG4105CUB amino acid HUT10_RS34470 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT10_RS34520 ENOG4107HP6 Transcriptional regulator HUT10_RS34530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT10_RS34535 ENOG4105BZU Histidine kinase HUT10_RS34540 ENOG4108MKR lipoprotein lpqb HUT10_RS34550 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT10_RS34555 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT10_RS34570 ENOG4105PAD Hydrolase HUT10_RS34575 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT10_RS34605 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT10_RS34610 ENOG4108RAV Conserved protein HUT10_RS34625 ENOG4108Z66 YbaK ebsC protein HUT10_RS34630 ENOG4105EMN RNA polymerase sigma factor HUT10_RS34650 ENOG4105CBD Diacylglycerol kinase HUT10_RS34665 ENOG4108ZM9 phosphoglycerate mutase HUT10_RS34680 ENOG4105RV9 Transcriptional regulator HUT10_RS34690 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HUT10_RS34705 ENOG4108IJ8 ABC transporter HUT10_RS34710 ENOG4105E90 ABC transporter HUT10_RS34715 ENOG4105E90 ABC transporter HUT10_RS34740 ENOG4107GJV short-chain dehydrogenase reductase HUT10_RS34750 ENOG410829K Lysine exporter protein (Lyse ygga) HUT10_RS34755 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT10_RS34770 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT10_RS34790 ENOG4105BZ1 (ABC) transporter HUT10_RS34805 ENOG4105ETX regulatoR HUT10_RS34810 ENOG4105DCF alanine dehydrogenase HUT10_RS34830 ENOG4108K8K Transcriptional regulator HUT10_RS34835 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT10_RS34870 ENOG4105DWV Homoserine O-trans-acetylase HUT10_RS34885 ENOG4106R7G Glycoside hydrolase family 5 HUT10_RS34895 ENOG4108TCJ secreted hydrolase HUT10_RS34900 ENOG4107QX3 carboxylase HUT10_RS34910 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS34945 ENOG4105EMU Dehydrogenase HUT10_RS35015 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT10_RS35020 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS35025 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS35095 ENOG4105CHU acetyl-coa acetyltransferase HUT10_RS35100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT10_RS35105 ENOG4105EYF MMPL domain protein HUT10_RS35110 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS35115 ENOG4105BZU Histidine kinase HUT10_RS35165 ENOG4107S5I aldo keto reductase HUT10_RS35175 ENOG4108JPW Aminotransferase HUT10_RS35185 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT10_RS35215 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT10_RS35255 ENOG4105WF7 pyrroloquinoline quinone biosynthesis protein d HUT10_RS35260 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HUT10_RS35275 ENOG4105MWK D-amino acid dehydrogenase, small subunit HUT10_RS35280 ENOG4105C7K acetolactate synthase HUT10_RS35285 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) HUT10_RS35295 ENOG41076PI Short-chain dehydrogenase reductase Sdr HUT10_RS35315 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT10_RS35320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT10_RS35410 ENOG4105EYF MMPL domain protein HUT10_RS35440 ENOG4107TTQ Alpha beta hydrolase fold HUT10_RS35450 ENOG4106R7G Glycoside hydrolase family 5 HUT10_RS35470 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS35505 ENOG4105CIR epoxide hydrolase HUT10_RS35510 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS35545 ENOG4105C75 arginyL-tRNA synthetase HUT10_RS35550 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT10_RS35555 ENOG4105D6E homoserine dehydrogenase HUT10_RS35560 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT10_RS35565 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT10_RS35575 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT10_RS35580 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT10_RS35600 ENOG4105CKK Glycosyl transferase, family 2 HUT10_RS35605 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT10_RS35620 ENOG4105ESV Glycosyl transferase, family 4 HUT10_RS35630 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) HUT10_RS35635 ENOG4106DE0 ATP synthase HUT10_RS35640 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT10_RS35645 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT10_RS35655 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT10_RS35660 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT10_RS35665 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT10_RS35680 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT10_RS35690 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT10_RS35695 ENOG4108JGH Tetr family transcriptional regulator HUT10_RS35700 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HUT10_RS35705 ENOG4107S9F NmrA family HUT10_RS35715 ENOG4105N14 lysine exporter protein LysE YggA HUT10_RS35720 ENOG4105N14 lysine exporter protein LysE YggA HUT10_RS35725 ENOG4105N14 lysine exporter protein LysE YggA HUT10_RS35750 ENOG4105ECQ AraC Family Transcriptional Regulator HUT10_RS35755 ENOG4108IPT Naphthoate synthase HUT10_RS35775 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT10_RS35805 ENOG4105CMT Dihydroxyacetone kinase HUT10_RS35810 ENOG4108UTZ Dihydroxyacetone kinase HUT10_RS35850 ENOG4108YXU transcriptional regulator AsnC family HUT10_RS35885 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HUT10_RS35895 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT10_RS35900 ENOG4105EAC phosphoserine phosphatase HUT10_RS35930 ENOG4105VKD bioY protein HUT10_RS35940 ENOG4108RTU Aldolase HUT10_RS35945 ENOG4108RWI nicotinamidase HUT10_RS35950 ENOG4107RKP Nicotinate phosphoribosyltransferase HUT10_RS35955 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT10_RS35965 ENOG4105KXX peptidase s58 dmpa HUT10_RS36010 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HUT10_RS36015 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT10_RS36020 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT10_RS36025 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT10_RS36070 ENOG4105ECQ AraC Family Transcriptional Regulator HUT10_RS36095 ENOG4107RN6 Monooxygenase HUT10_RS36105 ENOG4107TB5 TRANSCRIPTIONal HUT10_RS36120 ENOG4105BZU Histidine kinase HUT10_RS36130 ENOG4105CHR reductase HUT10_RS36150 ENOG4105GWZ Roadblock lc7 family protein HUT10_RS36165 ENOG4105MGM doxx family HUT10_RS36175 ENOG4107YBY Hydrolase HUT10_RS36195 ENOG4107RN3 metallophosphoesterase HUT10_RS36200 ENOG4105VTS DnaJ-like, subfamily C HUT10_RS36225 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HUT10_RS36280 ENOG4105ECQ AraC Family Transcriptional Regulator HUT10_RS36285 ENOG41082W1 Cupin 2, conserved barrel domain protein HUT10_RS36305 ENOG4105DYW oxidoreductase HUT10_RS36310 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT10_RS36320 ENOG4105CIR epoxide hydrolase HUT10_RS36325 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS36345 ENOG4105XEA Tetr family transcriptional regulator HUT10_RS36355 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT10_RS36415 ENOG4105CPC Aldo Keto reductase HUT10_RS36420 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT10_RS36425 ENOG4107EEY synthase HUT10_RS36435 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT10_RS36520 ENOG4107RCI amp-dependent synthetase and ligase HUT10_RS36525 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS36560 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT10_RS36600 ENOG4105EEX Two component transcriptional regulator (Winged helix family HUT10_RS36625 ENOG4105HSS phospholipase C HUT10_RS36630 ENOG4105DBE peroxidase HUT10_RS36635 ENOG410650H (LipO)protein HUT10_RS36640 ENOG41082BM Transcriptional regulator, arsr family HUT10_RS36660 ENOG4108DT4 serine threonine protein kinase HUT10_RS36680 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HUT10_RS36685 ENOG4105BZU Histidine kinase HUT10_RS36690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT10_RS36730 ENOG4105DVW rieske (2Fe-2S) HUT10_RS36735 ENOG4108RFG Tetr family transcriptional regulator HUT10_RS36780 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT10_RS36835 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT10_RS36840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT10_RS36870 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HUT10_RS36895 ENOG4108M6P methyltransferase HUT10_RS36900 ENOG41090MF Protein of unknown function (DUF3068) HUT10_RS36910 ENOG4105VMP Transcriptional regulator HUT10_RS36925 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS36955 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) HUT10_RS36960 ENOG4105KV4 Transcriptional regulator HUT10_RS36975 ENOG4105BZU Histidine kinase HUT10_RS37030 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT10_RS37035 ENOG4105C01 Dihydroxy-acid dehydratase HUT10_RS37040 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS37045 ENOG4105KF0 sporulation and cell division protein, SsgA HUT10_RS37050 ENOG4105K6V RNA polymerase HUT10_RS37080 ENOG4105CB2 alcohol dehydrogenase HUT10_RS37095 ENOG4107ZXU DSBA oxidoreductase HUT10_RS37105 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS37115 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT10_RS37125 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUT10_RS37155 ENOG41079KZ Major Facilitator Superfamily HUT10_RS37170 ENOG4105CPC Aldo Keto reductase HUT10_RS37220 ENOG4105GWZ Roadblock lc7 family protein HUT10_RS37235 ENOG4105BZU Histidine kinase HUT10_RS37265 ENOG4107YEV ferritin HUT10_RS37270 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HUT10_RS37275 ENOG4108MXZ Esterase HUT10_RS37290 ENOG4105CZV ABC transporter HUT10_RS37295 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT10_RS37310 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT10_RS37335 ENOG4105C0B DNA polymerase III (alpha subunit) HUT10_RS37340 ENOG4105E1F short-chain dehydrogenase reductase HUT10_RS37355 ENOG4105M4P Tetr family transcriptional regulator HUT10_RS37360 ENOG4105CYP glycoside hydrolase, family HUT10_RS37370 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HUT10_RS37375 ENOG4105CPC Aldo Keto reductase HUT10_RS37390 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT10_RS37400 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT10_RS37430 ENOG4105CX8 fg-gap repeat protein HUT10_RS37460 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT10_RS37465 ENOG4105C1Q protoporphyrinogen oxidase HUT10_RS37470 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUT10_RS37485 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT10_RS37505 ENOG4107T8Q Glycosyl transferase (Group 1 HUT10_RS37560 ENOG4105EX0 alpha-galactosidase HUT10_RS37570 ENOG4105CJ1 ABC, transporter HUT10_RS37595 ENOG4105BZU Histidine kinase HUT10_RS37600 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS37605 ENOG4108TM9 integral membrane protein HUT10_RS37630 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HUT10_RS37640 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT10_RS37645 ENOG4105CSH Transporter HUT10_RS37655 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUT10_RS37660 ENOG4105D7A ATP-binding protein HUT10_RS37670 ENOG4105C0H protease HUT10_RS37690 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT10_RS37700 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HUT10_RS37705 ENOG4106UDK Cellulose-binding, family II HUT10_RS37710 ENOG4106F60 Histidine kinase HUT10_RS37715 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT10_RS37720 ENOG4105EDW glycosyl transferase, family 39 HUT10_RS37730 ENOG4105CTK cobaltochelatase, cobn subunit HUT10_RS37760 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS37765 ENOG4105VZ8 Transcriptional regulator HUT10_RS37775 ENOG4105CJ1 ABC, transporter HUT10_RS37790 ENOG41081F0 Precorrin-8x methylmutase HUT10_RS37800 ENOG4105J1Z Arabinosyltransferase HUT10_RS37805 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HUT10_RS37825 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HUT10_RS37835 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HUT10_RS37840 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT10_RS37855 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT10_RS37865 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT10_RS37870 ENOG4108YZT Adenosylcobinamide kinase HUT10_RS37875 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUT10_RS37880 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT10_RS37920 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HUT10_RS37930 ENOG4105CBC glutamate synthase HUT10_RS37935 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUT10_RS37940 ENOG4105CWX Alpha-1,2-mannosidase HUT10_RS37945 ENOG41068WN HUT10_RS37970 ENOG4105C32 Amino acid ABC transporter (Permease) HUT10_RS37975 ENOG4105C32 Amino acid ABC transporter (Permease) HUT10_RS37980 ENOG4105C0Z ABC transporter HUT10_RS37985 ENOG4108IV0 ABC, transporter HUT10_RS37995 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS38005 ENOG4105CQB FAD linked oxidase domain protein HUT10_RS38010 ENOG4108RZE Tetr family transcriptional regulator HUT10_RS38020 ENOG4106YKD Cytochrome p-450 HUT10_RS38025 ENOG4105U3E Transcriptional regulator HUT10_RS38040 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT10_RS38050 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT10_RS38060 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT10_RS38085 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT10_RS38105 ENOG4105CHP RNA polymerase HUT10_RS38155 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT10_RS38160 ENOG4105BZU Histidine kinase HUT10_RS38185 ENOG4105DRR Transcriptional regulator, GntR family HUT10_RS38195 ENOG4105DCG PHP domain protein HUT10_RS38210 ENOG4105F95 Monooxygenase HUT10_RS38225 ENOG4105EG6 Saccharopine dehydrogenase HUT10_RS38230 ENOG4105DMF Dehydrogenase HUT10_RS38240 ENOG4105CQ7 ATP-dependent helicase HUT10_RS38295 ENOG4108UKI Enoyl-CoA hydratase HUT10_RS38340 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS38345 ENOG4107T8T UPF0173 metal-dependent hydrolase HUT10_RS38365 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT10_RS38370 ENOG4105CHU acetyl-coa acetyltransferase HUT10_RS38425 ENOG4105CUB amino acid HUT10_RS38435 ENOG4105ECM Sensor protein basS pmrB HUT10_RS38460 ENOG41060NJ transcriptional regulator HUT10_RS38480 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT10_RS38490 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT10_RS38505 ENOG4108MP6 LysR family Transcriptional regulator HUT10_RS38525 ENOG4105IQ5 FAD linked oxidase domain protein HUT10_RS38530 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS38550 ENOG4105C88 aminopeptidase HUT10_RS38565 ENOG4105CG3 alpha amylase, catalytic region HUT10_RS38585 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS38630 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT10_RS38640 ENOG4105EMU Dehydrogenase HUT10_RS38665 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT10_RS38680 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT10_RS38695 ENOG41067SE Tetr family transcriptional regulator HUT10_RS38705 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT10_RS38735 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS38750 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT10_RS38770 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT10_RS38795 ENOG4105C8V SAICAR synthetase HUT10_RS38805 ENOG4105CPC Aldo Keto reductase HUT10_RS38830 ENOG4107T4Z adenosine kinase HUT10_RS38840 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT10_RS38845 ENOG4108ZRS Part of cytochrome c oxidase, its function is HUT10_RS38850 ENOG4105ECQ AraC Family Transcriptional Regulator HUT10_RS38860 ENOG4108I0Q anthranilate phosphoribosyltransferase HUT10_RS38875 ENOG4105CCU oxidase (Subunit III) HUT10_RS38880 ENOG4107UDY cytochrome C HUT10_RS38890 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT10_RS38940 ENOG4106A3M Cytochrome p-450 HUT10_RS38945 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT10_RS38950 ENOG4105CHH sulfate transporter HUT10_RS38955 ENOG4105CHH sulfate transporter HUT10_RS38960 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT10_RS38965 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT10_RS38980 ENOG4105D0M Protease HtpX homolog HUT10_RS38995 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT10_RS39000 ENOG4108IYU L-aspartate oxidase HUT10_RS39005 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HUT10_RS39010 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HUT10_RS39060 ENOG4107F3J Amp-dependent synthetase and ligase HUT10_RS39095 ENOG4105EC2 ftsk spoIIIe HUT10_RS39130 ENOG4108MYR Secreted protein HUT10_RS39150 ENOG4108ZXC Two component transcriptional regulator, luxr family HUT10_RS39155 ENOG4108S01 response regulator HUT10_RS39165 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT10_RS39170 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT10_RS39175 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT10_RS39185 ENOG4105EYF MMPL domain protein HUT10_RS39190 ENOG4107XI7 Tetr family transcriptional regulator HUT10_RS39195 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HUT10_RS39200 ENOG4108Z4X TRANSCRIPTIONal HUT10_RS39225 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS39240 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT10_RS39245 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT10_RS39250 ENOG4108RFG Tetr family transcriptional regulator HUT10_RS39280 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT10_RS39290 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT10_RS39325 ENOG4105CRQ synthase (Component I) HUT10_RS39335 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT10_RS39340 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT10_RS39345 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT10_RS39355 ENOG4105C5F glutamine synthetase HUT10_RS39370 ENOG4105CH2 amidohydrolase HUT10_RS39375 ENOG4107V6M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT10_RS39385 ENOG4105CBC glutamate synthase HUT10_RS39420 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT10_RS39445 ENOG4105DZ6 Band 7 protein HUT10_RS39545 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT10_RS39555 ENOG4105E98 transcriptional regulator DeoR family HUT10_RS39565 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HUT10_RS39580 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT10_RS39585 ENOG4105KC9 Modulates RecA activity (By similarity) HUT10_RS39600 ENOG4108UHU Aldolase HUT10_RS39605 ENOG4105C01 Dihydroxy-acid dehydratase HUT10_RS39620 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUT10_RS39635 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT10_RS39670 ENOG4105CHR reductase HUT10_RS39675 ENOG4105DRP amino acid AbC transporter HUT10_RS39680 ENOG4108Q1T ABC transporter HUT10_RS39685 ENOG4107UBR Extracellular solute-binding protein family 3 HUT10_RS39690 ENOG4105CDA abc transporter atp-binding protein HUT10_RS39700 ENOG4105DHQ Histidine kinase HUT10_RS39760 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT10_RS39775 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT10_RS39785 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT10_RS39800 ENOG4105C99 atpase involved in dna repair HUT10_RS39805 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT10_RS39810 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT10_RS39815 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT10_RS39830 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT10_RS39840 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT10_RS39850 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUT10_RS39855 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT10_RS39920 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HUT10_RS39925 ENOG4105GFG DUF218 domain HUT10_RS39935 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS39955 ENOG4105CMR udp-glucose 4-epimerase HUT10_RS39960 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT10_RS39970 ENOG4105KHC sulfurtransferase HUT10_RS39975 ENOG4105DGU Histone deacetylase HUT10_RS39990 ENOG4108KC2 acyl-Coa dehydrogenase HUT10_RS39995 ENOG4105X7H acyl-CoA dehydrogenase HUT10_RS40005 ENOG4108KEZ Dehydrogenase HUT10_RS40075 ENOG4105XT2 Transcriptional regulator HUT10_RS40090 ENOG4107KJX Transcriptional regulator HUT10_RS40105 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT10_RS40120 ENOG4108IQE Amp-dependent synthetase and ligase HUT10_RS40150 ENOG4105DKQ ROK family HUT10_RS40160 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HUT10_RS40185 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HUT10_RS40210 ENOG4105KVH Transcriptional regulator HUT10_RS40215 ENOG41082BM Transcriptional regulator, arsr family HUT10_RS40240 ENOG4105C29 acyl-CoA thioesterase HUT10_RS40260 ENOG4107SM8 Adenylate Guanylate cyclase HUT10_RS40265 ENOG4105C26 Dehydrogenase HUT10_RS40280 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS40285 ENOG410846T CoA-transferase family III HUT10_RS40330 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT10_RS40335 ENOG4107QN1 sodium solute HUT10_RS40350 ENOG4105GWZ Roadblock lc7 family protein HUT10_RS40365 ENOG4105NAE bifunctional deaminase-reductase domain protein HUT10_RS40385 ENOG4105D5P Methylmalonyl-coA mutase HUT10_RS40390 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT10_RS40400 ENOG4108SGK Tetr family transcriptional regulator HUT10_RS40405 ENOG4105D2B acyl-CoA dehydrogenase HUT10_RS40410 ENOG4105C0D helicase HUT10_RS40445 ENOG4108RK3 acyl-Coa dehydrogenase HUT10_RS40450 ENOG4105X7H acyl-CoA dehydrogenase HUT10_RS40455 ENOG410900P UPF0336 protein HUT10_RS40475 ENOG4105DTN riboflavin biosynthesis protein ribF HUT10_RS40500 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HUT10_RS40510 ENOG4108KC1 acyl-Coa dehydrogenase HUT10_RS40515 ENOG41088PD hydrolase HUT10_RS40520 ENOG4105H37 Glyoxalase Bleomycin resistance protein (Dioxygenase HUT10_RS40525 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT10_RS40530 ENOG41067QZ Membrane HUT10_RS40550 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT10_RS40580 ENOG4105C57 major facilitator superfamily HUT10_RS40585 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HUT10_RS40645 ENOG4105E1V na solute symporter HUT10_RS40650 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT10_RS40655 ENOG4108VQT Alpha beta hydrolase fold protein HUT10_RS40665 ENOG4105F2C Acetyl-CoA acetyltransferase HUT10_RS40670 ENOG4106A3M Cytochrome p-450 HUT10_RS40685 ENOG4107H3J ribonuclease HUT10_RS40740 ENOG4105FDP GntR family transcriptional regulator HUT10_RS40755 ENOG4106SPC secreted protein HUT10_RS40760 ENOG4107GFK fumarate HUT10_RS40770 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT10_RS40780 ENOG4105CH2 amidohydrolase HUT10_RS40790 ENOG4105D7K pfkb domain protein HUT10_RS40795 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HUT10_RS40835 ENOG4105DFW ABC transporter HUT10_RS40840 ENOG4105C2J ABC transporter HUT10_RS40845 ENOG4108HWW ABC transporter HUT10_RS40875 ENOG4105CUB amino acid HUT10_RS40890 ENOG4105IIP Membrane HUT10_RS40920 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT10_RS40925 ENOG4105CG3 alpha amylase, catalytic region HUT10_RS40935 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT10_RS40950 ENOG4105DFK Polyphosphate glucokinase HUT10_RS40975 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT10_RS41005 ENOG4107VEG TrkA-N domain protein HUT10_RS41010 ENOG4105C0X amino acid HUT10_RS41015 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT10_RS41035 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT10_RS41045 ENOG4105C26 Dehydrogenase HUT10_RS41070 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT10_RS41075 ENOG4106F60 Histidine kinase HUT10_RS41095 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT10_RS41100 ENOG4105CHU acetyl-coa acetyltransferase HUT10_RS41145 ENOG4105MKU Transcriptional regulator HUT10_RS41160 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS41170 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT10_RS41180 ENOG4107JTW chlorite dismutase HUT10_RS41185 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F HUT10_RS41205 ENOG4105E18 UPF0276 protein HUT10_RS41220 ENOG4105E0X reductase HUT10_RS41230 ENOG4105D9P serine threonine protein kinase HUT10_RS41240 ENOG4105DQE DNA ligase HUT10_RS41255 ENOG4105DEN Luciferase family HUT10_RS41260 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT10_RS41270 ENOG4108K8K Transcriptional regulator HUT10_RS41275 ENOG4105C26 Dehydrogenase HUT10_RS41285 ENOG41080RH Thioredoxin HUT10_RS41300 ENOG4105CHP RNA polymerase HUT10_RS41340 ENOG4105VBF alkaline shock protein HUT10_RS41350 ENOG4105EMN RNA polymerase sigma factor HUT10_RS41385 ENOG4105C8Y Acetylornithine aminotransferase HUT10_RS41390 ENOG4105MHT Transcriptional regulator, ARSR family HUT10_RS41400 ENOG4105CSR polyphosphate kinase 2 HUT10_RS41420 ENOG41083TI Protein CrcB homolog HUT10_RS41425 ENOG4105KJJ Uncharacterized ACR, COG1993 HUT10_RS41430 ENOG41083YR Protein CrcB homolog HUT10_RS41450 ENOG4105CFQ glutamine synthetase HUT10_RS41460 ENOG4107SM8 Adenylate Guanylate cyclase HUT10_RS41480 ENOG4105C9M aspartyl-trna synthetase HUT10_RS41505 ENOG4106A3M Cytochrome p-450 HUT10_RS41525 ENOG4106KE4 Dehydrogenase HUT10_RS41540 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT10_RS41550 ENOG4105HHA aminodeoxychorismate lyase HUT10_RS41555 ENOG4105E2X shikimate dehydrogenase HUT10_RS41560 ENOG4105RHY Pfam:UPF0157 HUT10_RS41565 ENOG41082JN Transcriptional regulator HUT10_RS41575 ENOG4105F6J Alpha beta hydrolase fold HUT10_RS41600 ENOG41080Z8 PHOSPHOCARRIER protein HUT10_RS41620 ENOG4105C5Y PTS System HUT10_RS41645 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT10_RS41650 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUT10_RS41655 ENOG4105D49 3-dehydroquinate synthase HUT10_RS41660 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT10_RS41665 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HUT10_RS41685 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT10_RS41690 ENOG410803B Involved in the transcription termination process (By similarity) HUT10_RS41705 ENOG4105CXT aspartate transcarbamylase HUT10_RS41720 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT10_RS41730 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUT10_RS41740 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUT10_RS41745 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUT10_RS41755 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT10_RS41790 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUT10_RS41795 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT10_RS41820 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS41825 ENOG4105BZU Histidine kinase HUT10_RS41840 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT10_RS41845 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT10_RS41865 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT10_RS41870 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT10_RS41880 ENOG4105CIE May be required for sporulation (By similarity) HUT10_RS41885 ENOG4105C3Q Glycosyl transferase, family 2 HUT10_RS41915 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HUT10_RS41950 ENOG410829K Lysine exporter protein (Lyse ygga) HUT10_RS41960 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT10_RS41965 ENOG4105BZA Phosphoglycerate kinase HUT10_RS41970 ENOG4105CP7 Triose-phosphate isomerase HUT10_RS41990 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT10_RS41995 ENOG410630P Transcriptional regulator HUT10_RS42000 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT10_RS42005 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT10_RS42025 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT10_RS42035 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT10_RS42060 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT10_RS42100 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS42120 ENOG4107JC6 Membrane HUT10_RS42140 ENOG4105C3K feS assembly ATPase SufC HUT10_RS42150 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT10_RS42155 ENOG4105VG1 fes assembly suf system protein HUT10_RS42165 ENOG4105KK4 UPF0060 membrane protein HUT10_RS42175 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT10_RS42225 ENOG4105BZU Histidine kinase HUT10_RS42245 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT10_RS42260 ENOG4105C5H ABC transporter HUT10_RS42285 ENOG4105BZ1 (ABC) transporter HUT10_RS42295 ENOG4108SU4 UPF0309 protein HUT10_RS42305 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT10_RS42310 ENOG4108KGH TRANSCRIPTIONal HUT10_RS42325 ENOG4105BZU Histidine kinase HUT10_RS42350 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT10_RS42355 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT10_RS42365 ENOG41060WC Enoyl-CoA hydratase HUT10_RS42380 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS42385 ENOG4107QX3 carboxylase HUT10_RS42400 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT10_RS42430 ENOG4106UDK Cellulose-binding, family II HUT10_RS42435 ENOG4105BZU Histidine kinase HUT10_RS42470 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT10_RS42505 ENOG4105BZU Histidine kinase HUT10_RS42510 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS42520 ENOG4105S6R Iron-hydroxamate transporter permease subunit HUT10_RS42530 ENOG4105E0A ABC, transporter HUT10_RS42620 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUT10_RS42625 ENOG4108S4H thioesterase Superfamily protein HUT10_RS42635 ENOG4105K56 Transcriptional regulator HUT10_RS42650 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT10_RS42665 ENOG4105K6V RNA polymerase HUT10_RS42675 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT10_RS42690 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT10_RS42710 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT10_RS42715 ENOG4105CJN penicillin-binding protein HUT10_RS42720 ENOG4108ZHR arsR family transcriptional regulator HUT10_RS42730 ENOG4105C9B Cysteine desulfurase HUT10_RS42765 ENOG4105DYW oxidoreductase HUT10_RS42775 ENOG4107R33 ppx gppa phosphatase HUT10_RS42820 ENOG4108KQ5 Integrase catalytic subunit HUT10_RS42835 ENOG4105E2R ROK family HUT10_RS42880 ENOG4107Z3H Transcriptional regulator, TetR family HUT10_RS42885 ENOG4105EMU Dehydrogenase HUT10_RS42890 ENOG4105CPC Aldo Keto reductase HUT10_RS42895 ENOG4106JDQ ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB HUT10_RS42905 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT10_RS42915 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT10_RS42925 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT10_RS42945 ENOG4108Z4X TRANSCRIPTIONal HUT10_RS42960 ENOG41065SU Two-component system sensor kinase HUT10_RS42965 ENOG4108KXV response regulator HUT10_RS42985 ENOG4105EUB pirin domain protein HUT10_RS43045 ENOG4105CB2 alcohol dehydrogenase HUT10_RS43055 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HUT10_RS43080 ENOG4108XG2 Histidine kinase HUT10_RS43085 ENOG4105EBR Carboxylesterase HUT10_RS43090 ENOG4105C7W Xanthine dehydrogenase HUT10_RS43095 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT10_RS43100 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT10_RS43115 ENOG4105C26 Dehydrogenase HUT10_RS43125 ENOG4108TZY GntR Family Transcriptional Regulator HUT10_RS43140 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT10_RS43145 ENOG4105FUA antagonist HUT10_RS43150 ENOG4107MMM Anti-sigma-factor antagonist HUT10_RS43165 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT10_RS43170 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT10_RS43195 ENOG4105ECR NmrA family HUT10_RS43200 ENOG4105KVH Transcriptional regulator HUT10_RS43215 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS43225 ENOG4105D56 permease protein HUT10_RS43230 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT10_RS43250 ENOG4107S5I aldo keto reductase HUT10_RS43265 ENOG4105ECQ AraC Family Transcriptional Regulator HUT10_RS43275 ENOG4105CPC Aldo Keto reductase HUT10_RS43295 ENOG4105C8M UPF0272 protein HUT10_RS43300 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase HUT10_RS43305 ENOG4105QUH Domain of unknown function (DUF2088) HUT10_RS43315 ENOG4105ERH Fumarylacetoacetate hydrolase HUT10_RS43320 ENOG4105DIA mandelate racemase muconate lactonizing HUT10_RS43335 ENOG4105C2J ABC transporter HUT10_RS43375 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HUT10_RS43380 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS43385 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS43405 ENOG4105WQT MbtH domain protein HUT10_RS43425 ENOG4106A3M Cytochrome p-450 HUT10_RS43485 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT10_RS43495 ENOG4106R7G Glycoside hydrolase family 5 HUT10_RS43500 ENOG4105J5T Amp-dependent synthetase and ligase HUT10_RS43520 ENOG4105DZ2 Transcriptional regulator HUT10_RS43530 ENOG4105EMU Dehydrogenase HUT10_RS43535 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS43545 ENOG4105CXK mandelate racemase muconate lactonizing HUT10_RS43550 ENOG4105DRS transport system, permease HUT10_RS43555 ENOG4105EG2 ABC transporter, permease HUT10_RS43600 ENOG4105C0W non-ribosomal peptide synthetase HUT10_RS43650 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT10_RS43685 ENOG4105GWZ Roadblock lc7 family protein HUT10_RS43690 ENOG4105BZU Histidine kinase HUT10_RS43720 ENOG4105E2R ROK family HUT10_RS43730 ENOG4105C2J ABC transporter HUT10_RS43735 ENOG4105CNN ABC, transporter HUT10_RS43810 ENOG4107RE3 peptidase, S41 HUT10_RS43840 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT10_RS43900 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS43905 ENOG4105CJ1 ABC, transporter HUT10_RS43930 ENOG41067QW Transcriptional regulator HUT10_RS43960 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT10_RS43980 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT10_RS44005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT10_RS44015 ENOG4105FBW Monooxygenase HUT10_RS44065 ENOG4105ECR NmrA family HUT10_RS44095 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT10_RS44115 ENOG4105D9U N-acetyltransferase HUT10_RS44130 ENOG4105EAD ABC transporter HUT10_RS44175 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS44215 ENOG4105G9B Transcriptional regulator HUT10_RS44220 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT10_RS44230 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT10_RS44235 ENOG4105K64 Glycosyl transferase, family 2 HUT10_RS44245 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS44255 ENOG4105DFH Transport of potassium into the cell (By similarity) HUT10_RS44260 ENOG4105BZF Glycosyl transferase (Group 1 HUT10_RS44300 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUT10_RS44315 ENOG4105EMY transcriptional regulator HUT10_RS44355 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT10_RS44370 ENOG4105WH1 Two component transcriptional regulator luxr family HUT10_RS44380 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT10_RS44390 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HUT10_RS44455 ENOG4105CHR reductase HUT10_RS44465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT10_RS44480 ENOG4106DE0 ATP synthase HUT10_RS44495 ENOG4107S46 esterase, PHB depolymerase HUT10_RS44500 ENOG4105ECY inositol monophosphatase HUT10_RS44505 ENOG4105G2Y Transcriptional regulator HUT10_RS44545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT10_RS44670 ENOG4106A3M Cytochrome p-450 HUT10_RS44740 ENOG4106ARF phosphopantetheine-binding protein HUT10_RS44750 ENOG4105DRS transport system, permease HUT10_RS44765 ENOG41060NJ transcriptional regulator HUT10_RS44850 ENOG4108KDT Molybdate metabolism regulator HUT10_RS44870 ENOG4108M8W Monooxygenase HUT10_RS44880 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUT10_RS44890 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HUT10_RS44895 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HUT10_RS44900 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HUT10_RS44905 ENOG4105C26 Dehydrogenase HUT10_RS44910 ENOG4105DZQ phospholipase D Transphosphatidylase HUT10_RS44940 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) HUT10_RS44995 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HUT10_RS45010 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT10_RS45085 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS45090 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HUT10_RS45110 ENOG4107S9F NmrA family HUT10_RS45155 ENOG4105DTQ mandelate racemase muconate lactonizing HUT10_RS45175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT10_RS45195 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT10_RS45235 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT10_RS45260 ENOG4105DE4 1-phosphofructokinase HUT10_RS45265 ENOG4107W7X Aldolase HUT10_RS45270 ENOG4108PJD permease HUT10_RS45305 ENOG4105ESP cell wall surface anchor family protein HUT10_RS45315 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS45330 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT10_RS45350 ENOG4107T4Z adenosine kinase HUT10_RS45375 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT10_RS45380 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT10_RS45385 ENOG4105C7W Xanthine dehydrogenase HUT10_RS45400 ENOG4105D8V Glucose sorbosone dehydrogenase HUT10_RS45485 ENOG410814C multidrug resistance protein HUT10_RS45505 ENOG4106R7G Glycoside hydrolase family 5 HUT10_RS45515 ENOG4107NHD transcriptional regulator HUT10_RS45520 ENOG4105DEN Luciferase family HUT10_RS45535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT10_RS45550 ENOG4108JQ6 ABC transporter HUT10_RS45560 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HUT10_RS45565 ENOG4105DWY Agmatine deiminase HUT10_RS45570 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT10_RS45580 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HUT10_RS45605 ENOG4108M15 ABC transporter HUT10_RS45620 ENOG4105C0D helicase HUT10_RS45625 ENOG4107XWB Zinc finger, swim domain protein HUT10_RS45640 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT10_RS45670 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT10_RS45690 ENOG4105NAE bifunctional deaminase-reductase domain protein HUT10_RS45725 ENOG4105K63 Thioredoxin HUT10_RS45730 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT10_RS45740 ENOG4105DVC DnaJ domain protein HUT10_RS45745 ENOG410827T Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT10_RS45750 ENOG4105CFG Acts as a chaperone (By similarity) HUT10_RS45770 ENOG4105CG3 alpha amylase, catalytic region HUT10_RS45805 ENOG4105VBF alkaline shock protein HUT10_RS45830 ENOG4105DU6 RNA polymerase HUT10_RS45890 ENOG4107QN2 dihydrolipoyl dehydrogenase HUT10_RS45900 ENOG4105E2A Dehydrogenase HUT10_RS45905 ENOG4108IXY short-chain dehydrogenase reductase HUT10_RS45910 ENOG4108JGH Tetr family transcriptional regulator HUT10_RS45920 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT10_RS45970 ENOG4105EMN RNA polymerase sigma factor HUT10_RS46015 ENOG4105CSH Transporter HUT10_RS46105 ENOG4108KEZ Dehydrogenase HUT10_RS46115 ENOG4105C0W non-ribosomal peptide synthetase HUT10_RS46120 ENOG4105C0W non-ribosomal peptide synthetase HUT10_RS46130 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HUT10_RS46160 ENOG4105C0W non-ribosomal peptide synthetase HUT10_RS46165 ENOG4107EEY synthase HUT10_RS46195 ENOG4105CHH sulfate transporter HUT10_RS46210 ENOG4105EBM Alpha Beta Hydrolase Fold protein HUT10_RS46275 ENOG4108HMN Caspase domain HUT10_RS46290 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HUT10_RS46350 ENOG4107S9F NmrA family HUT10_RS46395 ENOG41062D9 Histidine kinase HUT10_RS46400 ENOG4105ETX regulatoR HUT10_RS46435 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT10_RS46530 ENOG4105E1F short-chain dehydrogenase reductase HUT10_RS46665 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT10_RS46680 ENOG4105EUJ GTP cyclohydrolase i HUT10_RS46685 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT10_RS46705 ENOG4105CGD Nad-dependent epimerase dehydratase HUT10_RS46830 ENOG4105CQS hydrogenase expression formation protein HypD HUT10_RS46840 ENOG4105C8H hydrogenase maturation protein Hypf HUT10_RS46850 ENOG4107SHJ sulfite reductase subunit b HUT10_RS46920 ENOG41062D9 Histidine kinase HUT10_RS46950 ENOG41061GT Aldolase HUT10_RS46960 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HUT10_RS46965 ENOG4105DDK oxidoreductase, beta subunit HUT10_RS46970 ENOG4105BZ8 glutamate synthase HUT10_RS46985 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT10_RS47005 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT10_RS47045 ENOG4105CSR polyphosphate kinase 2 HUT10_RS47060 ENOG4108YV4 Universal stress protein HUT10_RS47065 ENOG4105CJW magnesium transporter HUT10_RS47105 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HUT10_RS47115 ENOG4107QRI Phosphoketolase HUT10_RS47135 ENOG4108JJ9 ABC, transporter HUT10_RS47140 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT10_RS47175 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT10_RS47215 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT10_RS47220 ENOG4105CIG ABC transporter HUT10_RS47225 ENOG4105DIM ABC transporter HUT10_RS47240 ENOG4105CJW magnesium transporter HUT10_RS47250 ENOG4108YV4 Universal stress protein HUT10_RS47265 ENOG4105E2A Dehydrogenase HUT10_RS47310 ENOG4105C2J ABC transporter HUT10_RS47315 ENOG4105EPW hflc protein HUT10_RS47320 ENOG4105CEP NADH dehydrogenase HUT10_RS47390 ENOG4105CHR reductase HUT10_RS47435 ENOG4105EDW glycosyl transferase, family 39 HUT10_RS47465 ENOG4105CNT hydrolase family 2 HUT10_RS47480 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS47490 ENOG4105CBP Major Facilitator HUT10_RS47495 ENOG4105HFT AraC family transcriptional regulator HUT10_RS47520 ENOG4105CY0 Metallo-Beta-Lactamase HUT10_RS47525 ENOG4105EBR Carboxylesterase HUT10_RS47545 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT10_RS47585 ENOG4107FW0 short-chain dehydrogenase reductase HUT10_RS47605 ENOG4105CEY Amp-dependent synthetase and ligase HUT10_RS47620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT10_RS47630 ENOG4105C1G acyl-Coa dehydrogenase HUT10_RS47665 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HUT10_RS47710 ENOG4105CV8 reductase HUT10_RS47720 ENOG4105E2A Dehydrogenase HUT10_RS47755 ENOG41065SU Two-component system sensor kinase HUT10_RS47780 ENOG41088YS Glycosyl transferase (Group 1 HUT10_RS47790 ENOG4107S5I aldo keto reductase HUT10_RS47870 ENOG41089UC methyltransferase, type 11 HUT10_RS47880 ENOG41082BM Transcriptional regulator, arsr family HUT10_RS47895 ENOG4105HS2 Arsenate reductase HUT10_RS47905 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HUT10_RS47910 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HUT10_RS47920 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HUT10_RS47930 ENOG4105HS2 Arsenate reductase HUT10_RS47955 ENOG41089UC methyltransferase, type 11 HUT10_RS47970 ENOG4105CPF Cell wall formation (By similarity) HUT10_RS47980 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT10_RS48060 ENOG4108Z4X TRANSCRIPTIONal HUT10_RS48260 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HUT10_RS48285 ENOG4105ZXU NLP P60 protein HUT10_RS48340 ENOG4105CPQ Dehydrogenase HUT10_RS48400 ENOG4107SM8 Adenylate Guanylate cyclase HUT10_RS48425 ENOG4105DRR Transcriptional regulator, GntR family HUT10_RS48430 ENOG4105CPQ Dehydrogenase HUT10_RS48480 ENOG4105CHJ isochorismatase hydrolase HUT10_RS48490 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT10_RS48515 ENOG4105IKQ hydratase HUT10_RS48535 ENOG4105DP7 Protocatechuate 4,5-dioxygenase HUT10_RS48560 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HUT10_RS48565 ENOG4107RGD Major Facilitator superfamily HUT10_RS48580 ENOG4105H1N peptidase, M24 HUT10_RS48590 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS48610 ENOG4105C7S Dehydrogenase HUT10_RS48620 ENOG4105C26 Dehydrogenase HUT10_RS48665 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HUT10_RS48700 ENOG4105KF0 sporulation and cell division protein, SsgA HUT10_RS48710 ENOG4105D3Q Sugar transferase HUT10_RS48715 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT10_RS48720 ENOG4105C22 threonyL-tRNA synthetase HUT10_RS48745 ENOG4105E2K Glycosyl transferase (Group 1 HUT10_RS48770 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HUT10_RS48780 ENOG4105DNP FAD linked oxidase domain protein HUT10_RS48790 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT10_RS48795 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT10_RS48805 ENOG4108IMY Transcriptional regulator HUT10_RS48820 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT10_RS48825 ENOG4105CDY transcriptional regulatory protein HUT10_RS48845 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT10_RS48850 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT10_RS48855 ENOG4105ZCJ preprotein translocase subunit yajC HUT10_RS48865 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT10_RS48870 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT10_RS48875 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT10_RS48880 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT10_RS48915 ENOG4106HB6 Alpha beta hydrolase HUT10_RS48935 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HUT10_RS48940 ENOG4105C5X domain protein HUT10_RS49005 ENOG4108TQ9 Histidine kinase HUT10_RS49010 ENOG4105GWZ Roadblock lc7 family protein HUT10_RS49030 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT10_RS49045 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT10_RS49090 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HUT10_RS49110 ENOG4105EGE secreted protein HUT10_RS49125 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS49195 ENOG4105CNA YD repeat protein HUT10_RS49205 ENOG4105CSH Transporter HUT10_RS49225 ENOG4105EEM helicase HUT10_RS49225 ENOG4105EEM helicase HUT10_RS49230 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HUT10_RS49240 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT10_RS49245 ENOG4106NZI LysR family Transcriptional regulator HUT10_RS49285 ENOG4105CV8 reductase HUT10_RS49350 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT10_RS49355 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HUT10_RS49380 ENOG4105DRS transport system, permease HUT10_RS49395 ENOG4105ETE Transcriptional regulator (LacI family HUT10_RS49400 ENOG4105CYP glycoside hydrolase, family HUT10_RS49405 ENOG4106R7G Glycoside hydrolase family 5 HUT10_RS49410 ENOG41065HY 1,4-beta-cellobiosidase HUT10_RS49415 ENOG4108XET gCN5-related N-acetyltransferase HUT10_RS49435 ENOG4107QKS N-acylglucosamine 2-epimerase HUT10_RS49440 ENOG4105CPC Aldo Keto reductase HUT10_RS49445 ENOG4106R7G Glycoside hydrolase family 5 HUT10_RS49480 ENOG4105C54 Major Facilitator superfamily HUT10_RS49490 ENOG4105C3R Methionine synthase HUT10_RS49510 ENOG4105VF7 tolerance protein HUT10_RS49525 ENOG4108S01 response regulator HUT10_RS49535 ENOG4105ENE Histidine kinase HUT10_RS49540 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HUT10_RS49590 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HUT10_RS49620 ENOG4105CPC Aldo Keto reductase HUT10_RS49675 ENOG4106T9R serine protease HUT10_RS49685 ENOG4108Q5F Tetr family transcriptional regulator HUT10_RS49690 ENOG4108KDQ Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons (By similarity) HUT10_RS49700 ENOG4105MKU Transcriptional regulator HUT10_RS49725 ENOG4105C0W non-ribosomal peptide synthetase