locus-tag	class	description
L1857_RS00020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1857_RS00040	COG1408	metallophosphoesterase
L1857_RS00060	COG0783	Belongs to the Dps family
L1857_RS00065	COG1764	response to oxidative stress
L1857_RS00075	COG0657	acetylesterase activity
L1857_RS00115	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L1857_RS00120	COG0667	Aldo Keto reductase
L1857_RS00165	COG1132	(ABC) transporter
L1857_RS00170	COG1132	(ABC) transporter
L1857_RS00180	COG0515	serine threonine protein kinase
L1857_RS00200	COG0583	DNA-binding transcription factor activity
L1857_RS00205	COG0697	spore germination
L1857_RS00215	COG4608	Belongs to the ABC transporter superfamily
L1857_RS00220	COG0444	Belongs to the ABC transporter superfamily
L1857_RS00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_RS00230	COG0601	transmembrane transport
L1857_RS00235	COG0747	negative chemotaxis
L1857_RS00245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L1857_RS00250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1857_RS00255	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1857_RS00270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L1857_RS00280	COG2205	protein histidine kinase activity
L1857_RS00285	COG0745	RESPONSE REGULATOR receiver
L1857_RS00315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L1857_RS00335	COG1959	2 iron, 2 sulfur cluster binding
L1857_RS00345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L1857_RS00355	COG5001	Diguanylate cyclase
L1857_RS00445	COG1278	Cold shock
L1857_RS00465	COG0477	Major facilitator Superfamily
L1857_RS00475	COG0515	serine threonine protein kinase
L1857_RS00480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_RS00535	COG2188	Transcriptional regulator
L1857_RS00605	COG2391	methyltransferase activity
L1857_RS00610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1857_RS00615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L1857_RS00640	COG1609	Transcriptional regulator
L1857_RS00645	COG2814	Major facilitator Superfamily
L1857_RS00655	COG3250	beta-galactosidase activity
L1857_RS00675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1857_RS00730	COG0477	Major facilitator Superfamily
L1857_RS00735	COG1960	acyl-CoA dehydrogenase activity
L1857_RS00740	COG1309	transcriptional regulator
L1857_RS00760	COG0247	lactate metabolic process
L1857_RS00760	COG2181	nitrate reductase activity
L1857_RS00765	COG2076	Multidrug Resistance protein
L1857_RS00790	COG0443	Heat shock 70 kDa protein
L1857_RS00800	COG0484	heat shock protein binding
L1857_RS00805	COG0789	Transcriptional regulator
L1857_RS00810	COG2801	Transposase and inactivated derivatives
L1857_RS00820	COG0412	Dienelactone hydrolase
L1857_RS00835	COG0477	Major facilitator Superfamily
L1857_RS00840	COG3547	Transposase (IS116 IS110 IS902 family)
L1857_RS00845	COG0542	response to heat
L1857_RS00855	COG4221	oxidoreductase activity
L1857_RS00865	COG2318	DinB family
L1857_RS00880	COG1053	succinate dehydrogenase
L1857_RS00885	COG2223	nitrite transmembrane transporter activity
L1857_RS00890	COG0583	DNA-binding transcription factor activity
L1857_RS00910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_RS00915	COG0243	molybdopterin cofactor binding
L1857_RS00925	COG1609	Transcriptional regulator
L1857_RS00950	COG1072	(Pantothenic acid kinase))
L1857_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS00990	COG0586	Pfam SNARE associated Golgi protein
L1857_RS00995	COG2353	YceI-like domain
L1857_RS01005	COG1846	Transcriptional regulator
L1857_RS01010	COG0277	FAD linked oxidase domain protein
L1857_RS01015	COG0586	Pfam SNARE associated Golgi protein
L1857_RS01050	COG0300	oxidoreductase activity
L1857_RS01055	COG0667	Aldo Keto reductase
L1857_RS01095	COG4172	Belongs to the ABC transporter superfamily
L1857_RS01100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_RS01105	COG0601	transmembrane transport
L1857_RS01110	COG0747	negative chemotaxis
L1857_RS01135	COG0025	NhaP-type Na H and K H
L1857_RS01140	COG5650	phosphatidylinositol metabolic process
L1857_RS01145	COG0477	Major facilitator Superfamily
L1857_RS01180	COG5280	Phage tail tape measure protein TP901
L1857_RS01180	COG3953	SLT domain
L1857_RS01185	COG0436	Aminotransferase
L1857_RS01220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L1857_RS01240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1857_RS01245	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS01250	COG1376	ErfK ybiS ycfS ynhG family protein
L1857_RS01285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1857_RS01290	COG0047	phosphoribosylformylglycinamidine synthase activity
L1857_RS01295	COG1132	(ABC) transporter
L1857_RS01300	COG1132	(ABC) transporter
L1857_RS01305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L1857_RS01380	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L1857_RS01385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L1857_RS01425	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS01445	COG1984	allophanate hydrolase subunit 2
L1857_RS01455	COG4044	May play a role in the intracellular transport of hydrophobic ligands
L1857_RS01485	COG0745	RESPONSE REGULATOR receiver
L1857_RS01490	COG0456	acetyltransferase
L1857_RS01490	COG0454	-acetyltransferase
L1857_RS01510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1857_RS01530	COG2357	RelA SpoT domain protein
L1857_RS01535	COG0704	Plays a role in the regulation of phosphate uptake
L1857_RS01555	COG0737	Belongs to the 5'-nucleotidase family
L1857_RS01555	COG1525	nuclease
L1857_RS01555	COG4085	toxin activity
L1857_RS01585	COG2197	response regulator
L1857_RS01590	COG1960	acyl-CoA dehydrogenase activity
L1857_RS01625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L1857_RS01665	COG3030	protein affecting phage T7 exclusion by the F plasmid
L1857_RS01675	COG1309	transcriptional regulator
L1857_RS01680	COG2030	dehydratase
L1857_RS01685	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS01690	COG0183	Belongs to the thiolase family
L1857_RS01705	COG1733	regulation of RNA biosynthetic process
L1857_RS01770	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L1857_RS01785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L1857_RS01795	COG4585	Histidine kinase
L1857_RS01800	COG2197	response regulator
L1857_RS01835	COG1136	(ABC) transporter
L1857_RS01845	COG2197	response regulator
L1857_RS01865	COG0402	S-adenosylhomocysteine deaminase activity
L1857_RS01870	COG0702	epimerase
L1857_RS01875	COG1309	transcriptional regulator
L1857_RS01895	COG4221	oxidoreductase activity
L1857_RS01915	COG2814	Major facilitator Superfamily
L1857_RS01920	COG1846	Transcriptional regulator
L1857_RS01930	COG0640	Transcriptional regulator
L1857_RS01935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L1857_RS01945	COG1695	Transcriptional regulator
L1857_RS01955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1857_RS01985	COG0360	Binds together with S18 to 16S ribosomal RNA
L1857_RS01995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L1857_RS02000	COG0359	binds to the 23S rRNA
L1857_RS02030	COG0789	Transcriptional regulator
L1857_RS02040	COG2267	carboxylic ester hydrolase activity
L1857_RS02060	COG3384	dioxygenase
L1857_RS02095	COG2205	protein histidine kinase activity
L1857_RS02100	COG2197	response regulator
L1857_RS02110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1857_RS02115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1857_RS02125	COG0495	leucyl-tRNA aminoacylation
L1857_RS02140	COG1678	Uncharacterized ACR, COG1678
L1857_RS02195	COG4585	Histidine kinase
L1857_RS02200	COG0617	tRNA 3'-terminal CCA addition
L1857_RS02225	COG1595	DNA-templated transcription, initiation
L1857_RS02240	COG0492	ferredoxin-NADP+ reductase activity
L1857_RS02240	COG3118	belongs to the thioredoxin family
L1857_RS02245	COG0860	N-Acetylmuramoyl-L-alanine amidase
L1857_RS02245	COG3409	Peptidoglycan-binding domain 1 protein
L1857_RS02260	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1857_RS02270	COG1192	Involved in chromosome partitioning
L1857_RS02275	COG0357	Ribosomal RNA small subunit methyltransferase G
L1857_RS02290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L1857_RS02310	COG0583	DNA-binding transcription factor activity
L1857_RS02320	COG0592	DNA-directed DNA polymerase activity
L1857_RS02325	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L1857_RS02330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L1857_RS02335	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
L1857_RS02340	COG0187	DNA topoisomerase II activity
L1857_RS02345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L1857_RS02490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1857_RS02505	COG2353	YceI-like domain
L1857_RS02570	COG0457	Tetratricopeptide repeat
L1857_RS02570	COG0705	Rhomboid family
L1857_RS02585	COG3764	Sortase (surface protein transpeptidase)
L1857_RS02625	COG0745	RESPONSE REGULATOR receiver
L1857_RS02630	COG2205	protein histidine kinase activity
L1857_RS02645	COG0515	serine threonine protein kinase
L1857_RS02650	COG0768	penicillin binding
L1857_RS02665	COG1716	ATPase activity
L1857_RS02670	COG1716	ATPase activity
L1857_RS02695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1857_RS02700	COG0583	DNA-binding transcription factor activity
L1857_RS02760	COG2186	Transcriptional regulator
L1857_RS02765	COG0747	negative chemotaxis
L1857_RS02775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_RS02785	COG4608	Belongs to the ABC transporter superfamily
L1857_RS02790	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS02795	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS02800	COG0154	amidase activity
L1857_RS02815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L1857_RS02825	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_RS02830	COG0515	serine threonine protein kinase
L1857_RS02875	COG2211	Major facilitator Superfamily
L1857_RS02905	COG2372	response to copper ion
L1857_RS02905	COG1276	copper resistance
L1857_RS02920	COG1174	glycine betaine transport
L1857_RS02930	COG1174	glycine betaine transport
L1857_RS02965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L1857_RS02980	COG0477	Major facilitator Superfamily
L1857_RS02990	COG3209	COG3209 Rhs family protein
L1857_RS03005	COG4585	Histidine kinase
L1857_RS03010	COG2197	response regulator
L1857_RS03025	COG0438	transferase activity, transferring glycosyl groups
L1857_RS03030	COG4106	trans-aconitate 2-methyltransferase activity
L1857_RS03070	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_RS03075	COG0022	dehydrogenase e1 component
L1857_RS03085	COG0683	leucine binding
L1857_RS03100	COG1022	Amp-dependent synthetase and ligase
L1857_RS03110	COG0410	ABC transporter
L1857_RS03115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_RS03125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_RS03130	COG0765	amino acid transport
L1857_RS03160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1857_RS03165	COG3275	phosphorelay sensor kinase activity
L1857_RS03175	COG3279	Response regulator of the LytR AlgR family
L1857_RS03185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_RS03195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_RS03200	COG0425	Belongs to the sulfur carrier protein TusA family
L1857_RS03200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L1857_RS03225	COG1191	sigma factor activity
L1857_RS03235	COG1528	Iron-storage protein
L1857_RS03280	COG1271	oxidase subunit
L1857_RS03285	COG1294	oxidase, subunit
L1857_RS03290	COG4988	ABC transporter
L1857_RS03320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1857_RS03330	COG1846	Transcriptional regulator
L1857_RS03335	COG1289	transmembrane transporter activity
L1857_RS03390	COG1072	(Pantothenic acid kinase))
L1857_RS03395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L1857_RS03405	COG0406	alpha-ribazole phosphatase activity
L1857_RS03420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_RS03445	COG0754	glutathionylspermidine amidase activity
L1857_RS03450	COG3766	membrane
L1857_RS03455	COG0596	Alpha beta hydrolase
L1857_RS03470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L1857_RS03475	COG3473	Maleate cis-trans isomerase
L1857_RS03490	COG0579	oxidoreductase
L1857_RS03520	COG2207	Transcriptional regulator
L1857_RS03525	COG2223	nitrite transmembrane transporter activity
L1857_RS03530	COG0673	inositol 2-dehydrogenase activity
L1857_RS03535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1857_RS03540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L1857_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS03585	COG0561	phosphatase activity
L1857_RS03590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS03605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1857_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS03630	COG0277	FAD linked oxidase domain protein
L1857_RS03640	COG1216	Glycosyl transferase, family 2
L1857_RS03650	COG1216	Glycosyl transferase, family 2
L1857_RS03670	COG2089	acid synthase
L1857_RS03700	COG1063	alcohol dehydrogenase
L1857_RS03705	COG2234	aminopeptidase activity
L1857_RS03740	COG2188	Transcriptional regulator
L1857_RS03775	COG0443	Heat shock 70 kDa protein
L1857_RS03805	COG4585	Histidine kinase
L1857_RS03810	COG2197	response regulator
L1857_RS03825	COG1522	sequence-specific DNA binding
L1857_RS03845	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L1857_RS03875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1857_RS03885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_RS03890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L1857_RS03890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L1857_RS03925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS03930	COG2124	cytochrome p450
L1857_RS03940	COG0477	Major facilitator Superfamily
L1857_RS03950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS03975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L1857_RS03980	COG2814	Major facilitator Superfamily
L1857_RS03985	COG1309	transcriptional regulator
L1857_RS03990	COG1937	Protein conserved in bacteria
L1857_RS03995	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
L1857_RS04010	COG2072	flavoprotein involved in K transport
L1857_RS04020	COG0028	Belongs to the TPP enzyme family
L1857_RS04025	COG0248	Ppx GppA phosphatase
L1857_RS04040	COG2723	6-phospho-beta-galactosidase activity
L1857_RS04065	COG1309	transcriptional regulator
L1857_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS04085	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS04090	COG1120	ATPase activity
L1857_RS04095	COG1280	lysine exporter protein (LysE YggA)
L1857_RS04110	COG3559	Exporter of polyketide antibiotics
L1857_RS04115	COG1131	(ABC) transporter
L1857_RS04185	COG0287	Prephenate dehydrogenase
L1857_RS04190	COG1473	amidohydrolase
L1857_RS04240	COG1674	ftsk spoiiie
L1857_RS04260	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L1857_RS04270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1857_RS04285	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_RS04295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS04300	COG0427	acetyl-CoA hydrolase
L1857_RS04310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1857_RS04315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1857_RS04320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L1857_RS04335	COG0444	Belongs to the ABC transporter superfamily
L1857_RS04340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_RS04345	COG0601	transmembrane transport
L1857_RS04350	COG0747	negative chemotaxis
L1857_RS04370	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
L1857_RS04380	COG1414	Transcriptional regulator
L1857_RS04385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1857_RS04400	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_RS04405	COG0277	FAD linked oxidase domain protein
L1857_RS04410	COG0247	lactate metabolic process
L1857_RS04440	COG2200	EAL domain
L1857_RS04465	COG1472	Belongs to the glycosyl hydrolase 3 family
L1857_RS04535	COG0542	response to heat
L1857_RS04540	COG2364	Membrane
L1857_RS04545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_RS04565	COG2733	membrane
L1857_RS04585	COG1136	(ABC) transporter
L1857_RS04600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1857_RS04605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L1857_RS04630	COG1174	glycine betaine transport
L1857_RS04650	COG2130	NADP-dependent
L1857_RS04690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L1857_RS04705	COG0438	transferase activity, transferring glycosyl groups
L1857_RS04715	COG0588	phosphoglycerate mutase activity
L1857_RS04725	COG0667	Aldo Keto reductase
L1857_RS04730	COG5002	protein histidine kinase activity
L1857_RS04755	COG0506	proline dehydrogenase activity
L1857_RS04770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L1857_RS04805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1857_RS04820	COG1595	DNA-templated transcription, initiation
L1857_RS04825	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS04840	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L1857_RS04845	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L1857_RS04850	COG0181	hydroxymethylbilane synthase activity
L1857_RS04855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1857_RS04855	COG1648	precorrin-2 dehydrogenase activity
L1857_RS04880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1857_RS04885	COG0406	alpha-ribazole phosphatase activity
L1857_RS04900	COG0785	Cytochrome C biogenesis protein
L1857_RS04910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L1857_RS04940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L1857_RS04960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L1857_RS04965	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L1857_RS04995	COG0438	transferase activity, transferring glycosyl groups
L1857_RS05000	COG2226	methyltransferase
L1857_RS05015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1857_RS05020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1857_RS05025	COG0649	NAD binding
L1857_RS05040	COG1034	ATP synthesis coupled electron transport
L1857_RS05045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L1857_RS05050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L1857_RS05055	COG0839	Belongs to the complex I subunit 6 family
L1857_RS05060	COG0713	ATP synthesis coupled electron transport
L1857_RS05065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L1857_RS05090	COG0142	geranyltranstransferase activity
L1857_RS05100	COG1013	pyruvate-flavodoxin oxidoreductase activity
L1857_RS05105	COG0674	pyruvate-flavodoxin oxidoreductase activity
L1857_RS05105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L1857_RS05115	COG1522	sequence-specific DNA binding
L1857_RS05120	COG1834	amidinotransferase
L1857_RS05130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1857_RS05150	COG1215	transferase activity, transferring glycosyl groups
L1857_RS05160	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
L1857_RS05165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L1857_RS05230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1857_RS05240	COG0297	glycogen (starch) synthase activity
L1857_RS05245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L1857_RS05270	COG0367	asparagine synthase
L1857_RS05290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L1857_RS05295	COG0501	Belongs to the peptidase M48B family
L1857_RS05305	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L1857_RS05310	COG0596	Alpha beta hydrolase
L1857_RS05320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L1857_RS05340	COG1666	GTP binding
L1857_RS05355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L1857_RS05390	COG2205	protein histidine kinase activity
L1857_RS05395	COG0745	RESPONSE REGULATOR receiver
L1857_RS05415	COG1136	(ABC) transporter
L1857_RS05415	COG0577	efflux transmembrane transporter activity
L1857_RS05425	COG4941	Belongs to the sigma-70 factor family
L1857_RS05430	COG1793	dna ligase
L1857_RS05445	COG3486	L-lysine 6-monooxygenase (NADPH) activity
L1857_RS05455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS05460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS05465	COG1021	2,3-dihydroxybenzoate-AMP ligase
L1857_RS05470	COG0477	Major facilitator Superfamily
L1857_RS05490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1857_RS05510	COG0438	transferase activity, transferring glycosyl groups
L1857_RS05520	COG2814	Major facilitator Superfamily
L1857_RS05530	COG2197	response regulator
L1857_RS05535	COG4585	Histidine kinase
L1857_RS05545	COG2132	Multicopper oxidase
L1857_RS05560	COG4585	Histidine kinase
L1857_RS05565	COG0586	Pfam SNARE associated Golgi protein
L1857_RS05570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L1857_RS05595	COG2030	dehydratase
L1857_RS05615	COG2755	lipolytic protein G-D-S-L family
L1857_RS05620	COG0436	Aminotransferase
L1857_RS05630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L1857_RS05645	COG0081	regulation of translation
L1857_RS05655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L1857_RS05660	COG0222	ribosome binding
L1857_RS05675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1857_RS05700	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L1857_RS05725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L1857_RS05750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L1857_RS05755	COG0049	tRNA binding
L1857_RS05760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L1857_RS05770	COG0051	transcription antitermination factor activity, RNA binding
L1857_RS05775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L1857_RS05780	COG0088	Forms part of the polypeptide exit tunnel
L1857_RS05785	COG0089	rRNA binding
L1857_RS05790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L1857_RS05795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L1857_RS05800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L1857_RS05805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L1857_RS05815	COG0255	Belongs to the universal ribosomal protein uL29 family
L1857_RS05820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L1857_RS05825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L1857_RS05830	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L1857_RS05835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L1857_RS05845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L1857_RS05850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L1857_RS05860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L1857_RS05865	COG1841	ribosomal large subunit assembly
L1857_RS05890	COG0563	adenylate kinase activity
L1857_RS05900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L1857_RS05905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L1857_RS05920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L1857_RS05925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L1857_RS05930	COG0202	RNA polymerase activity
L1857_RS05935	COG0203	ribosomal protein L17
L1857_RS05940	COG0101	tRNA pseudouridine synthase activity
L1857_RS05960	COG1404	Belongs to the peptidase S8 family
L1857_RS05970	COG1674	ftsk spoiiie
L1857_RS05975	COG0443	Heat shock 70 kDa protein
L1857_RS06000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L1857_RS06005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L1857_RS06010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1857_RS06035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1857_RS06050	COG1175	transmembrane transport
L1857_RS06055	COG0395	ABC-type sugar transport system, permease component
L1857_RS06060	COG1063	alcohol dehydrogenase
L1857_RS06065	COG1349	DNA-binding transcription factor activity
L1857_RS06070	COG1070	Carbohydrate kinase
L1857_RS06075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L1857_RS06085	COG0802	atpase or kinase
L1857_RS06095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L1857_RS06095	COG0825	malonyl-CoA metabolic process
L1857_RS06100	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS06110	COG2186	Transcriptional regulator
L1857_RS06120	COG0456	acetyltransferase
L1857_RS06125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L1857_RS06140	COG3540	Alkaline phosphatase
L1857_RS06145	COG1733	regulation of RNA biosynthetic process
L1857_RS06155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L1857_RS06160	COG0459	protein refolding
L1857_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS06170	COG1309	transcriptional regulator
L1857_RS06215	COG0516	GMP reductase activity
L1857_RS06245	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS06260	COG0519	Catalyzes the synthesis of GMP from XMP
L1857_RS06260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L1857_RS06295	COG0583	DNA-binding transcription factor activity
L1857_RS06305	COG0515	serine threonine protein kinase
L1857_RS06345	COG0739	heme binding
L1857_RS06360	COG0045	succinate-CoA ligase (ADP-forming) activity
L1857_RS06385	COG0138	bifunctional purine biosynthesis protein purh
L1857_RS06390	COG0667	Aldo Keto reductase
L1857_RS06410	COG0587	DNA-directed DNA polymerase activity
L1857_RS06415	COG2816	NAD+ diphosphatase activity
L1857_RS06430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1857_RS06440	COG2814	Major facilitator Superfamily
L1857_RS06480	COG1234	tRNA 3'-trailer cleavage
L1857_RS06485	COG0708	Exodeoxyribonuclease III
L1857_RS06500	COG0180	Tryptophanyl-tRNA synthetase
L1857_RS06505	COG1295	ribonuclease BN
L1857_RS06510	COG1686	Belongs to the peptidase S11 family
L1857_RS06535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L1857_RS06550	COG2009	succinate dehydrogenase
L1857_RS06555	COG1744	ABC transporter substrate-binding protein PnrA-like
L1857_RS06570	COG1079	Belongs to the binding-protein-dependent transport system permease family
L1857_RS06595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L1857_RS06600	COG2271	Major facilitator Superfamily
L1857_RS06630	COG2124	cytochrome p450
L1857_RS06640	COG1063	alcohol dehydrogenase
L1857_RS06655	COG0395	ABC-type sugar transport system, permease component
L1857_RS06665	COG2124	cytochrome p450
L1857_RS06680	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS06685	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS06690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L1857_RS06715	COG4106	trans-aconitate 2-methyltransferase activity
L1857_RS06730	COG0667	Aldo Keto reductase
L1857_RS06770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1857_RS06780	COG0515	serine threonine protein kinase
L1857_RS06805	COG1473	amidohydrolase
L1857_RS06805	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L1857_RS06835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L1857_RS06840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1857_RS06845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L1857_RS06870	COG4770	biotin carboxylase activity
L1857_RS06890	COG1301	dicarboxylic acid transport
L1857_RS06895	COG0424	maF-like protein
L1857_RS06910	COG1802	Transcriptional regulator
L1857_RS06925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1857_RS06940	COG0640	Transcriptional regulator
L1857_RS06945	COG3467	pyridoxamine 5'-phosphate
L1857_RS06990	COG0596	Alpha beta hydrolase
L1857_RS06995	COG3629	intracellular signal transduction
L1857_RS06995	COG3903	Transcriptional regulator
L1857_RS07005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1857_RS07010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS07020	COG0791	NLP P60 protein
L1857_RS07020	COG1388	LysM domain
L1857_RS07060	COG0483	inositol monophosphate 1-phosphatase activity
L1857_RS07065	COG0745	RESPONSE REGULATOR receiver
L1857_RS07070	COG2205	protein histidine kinase activity
L1857_RS07120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS07125	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS07140	COG2259	Doxx family
L1857_RS07150	COG1316	TRANSCRIPTIONal
L1857_RS07155	COG1316	TRANSCRIPTIONal
L1857_RS07175	COG4221	oxidoreductase activity
L1857_RS07180	COG0438	transferase activity, transferring glycosyl groups
L1857_RS07195	COG0438	transferase activity, transferring glycosyl groups
L1857_RS07230	COG1725	Transcriptional regulator
L1857_RS07245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L1857_RS07255	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L1857_RS07265	COG1309	transcriptional regulator
L1857_RS07290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_RS07295	COG1611	Belongs to the LOG family
L1857_RS07310	COG0463	Glycosyl transferase, family 2
L1857_RS07325	COG0519	Catalyzes the synthesis of GMP from XMP
L1857_RS07330	COG1024	Enoyl-CoA hydratase
L1857_RS07340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L1857_RS07345	COG0583	DNA-binding transcription factor activity
L1857_RS07350	COG2814	Major facilitator Superfamily
L1857_RS07365	COG4122	O-methyltransferase activity
L1857_RS07380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1857_RS07385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L1857_RS07400	COG2239	Acts as a magnesium transporter
L1857_RS07410	COG0330	HflC and HflK could
L1857_RS07415	COG1960	acyl-CoA dehydrogenase activity
L1857_RS07465	COG0598	Magnesium transport protein CorA
L1857_RS07480	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS07500	COG0613	PHP domain protein
L1857_RS07505	COG2095	MarC family integral membrane protein
L1857_RS07525	COG1309	transcriptional regulator
L1857_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS07550	COG0513	Belongs to the DEAD box helicase family
L1857_RS07580	COG2267	carboxylic ester hydrolase activity
L1857_RS07610	COG2319	Wd-40 repeat
L1857_RS07620	COG0243	molybdopterin cofactor binding
L1857_RS07625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1857_RS07630	COG2223	nitrite transmembrane transporter activity
L1857_RS07635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1857_RS07635	COG2146	nitrite reductase [NAD(P)H] activity
L1857_RS07670	COG2378	regulation of single-species biofilm formation
L1857_RS07700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1857_RS07730	COG0714	Associated with various cellular activities
L1857_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS07765	COG1309	transcriptional regulator
L1857_RS07780	COG0612	Peptidase, M16
L1857_RS07800	COG3265	gluconokinase activity
L1857_RS07810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L1857_RS07845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L1857_RS07895	COG3903	Transcriptional regulator
L1857_RS07895	COG3629	intracellular signal transduction
L1857_RS07915	COG3629	intracellular signal transduction
L1857_RS07915	COG3903	Transcriptional regulator
L1857_RS07935	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
L1857_RS07945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L1857_RS07960	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS07965	COG3842	ATPase activity
L1857_RS07970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L1857_RS07975	COG1176	ABC-type spermidine putrescine transport system, permease component I
L1857_RS07980	COG1177	transmembrane transport
L1857_RS07985	COG1968	undecaprenyl-diphosphatase activity
L1857_RS07990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L1857_RS08005	COG2318	DinB family
L1857_RS08015	COG0653	protein targeting
L1857_RS08045	COG0174	glutamine synthetase
L1857_RS08070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L1857_RS08080	COG0174	glutamine synthetase
L1857_RS08125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L1857_RS08145	COG3480	Lon protease (S16) C-terminal proteolytic domain
L1857_RS08155	COG1615	UPF0182 protein
L1857_RS08190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L1857_RS08195	COG2884	Cell division ATP-binding protein ftsE
L1857_RS08200	COG2177	Part of the ABC transporter FtsEX involved in
L1857_RS08205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L1857_RS08235	COG2197	response regulator
L1857_RS08255	COG3547	Transposase (IS116 IS110 IS902 family)
L1857_RS08260	COG1414	Transcriptional regulator
L1857_RS08265	COG2986	histidine ammonia-lyase
L1857_RS08270	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
L1857_RS08275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_RS08285	COG1228	amidohydrolase
L1857_RS08330	COG4585	Histidine kinase
L1857_RS08335	COG2197	response regulator
L1857_RS08345	COG1131	(ABC) transporter
L1857_RS08355	COG1643	Atp-dependent helicase
L1857_RS08415	COG2801	Transposase and inactivated derivatives
L1857_RS08440	COG0582	viral genome integration into host DNA
L1857_RS08550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1857_RS08555	COG2816	NAD+ diphosphatase activity
L1857_RS08570	COG2755	lipolytic protein G-D-S-L family
L1857_RS08600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1857_RS08690	COG3328	transposase activity
L1857_RS08725	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS08735	COG1960	acyl-CoA dehydrogenase activity
L1857_RS08755	COG1231	oxidoreductase activity
L1857_RS08775	COG4221	oxidoreductase activity
L1857_RS08795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1857_RS08820	COG1595	DNA-templated transcription, initiation
L1857_RS08830	COG4999	Histidine kinase
L1857_RS08830	COG3850	Histidine kinase
L1857_RS08830	COG3437	response regulator, receiver
L1857_RS08830	COG2205	protein histidine kinase activity
L1857_RS08835	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_RS08840	COG0583	DNA-binding transcription factor activity
L1857_RS08845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L1857_RS08855	COG0583	DNA-binding transcription factor activity
L1857_RS08860	COG1119	ATPase activity
L1857_RS08875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L1857_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS08910	COG1228	amidohydrolase
L1857_RS08950	COG0438	transferase activity, transferring glycosyl groups
L1857_RS08950	COG1216	Glycosyl transferase, family 2
L1857_RS08965	COG0477	Major facilitator Superfamily
L1857_RS08970	COG1309	transcriptional regulator
L1857_RS08975	COG0187	DNA topoisomerase II activity
L1857_RS08980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L1857_RS08985	COG3547	Transposase (IS116 IS110 IS902 family)
L1857_RS08995	COG2208	phosphoserine phosphatase activity
L1857_RS09000	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_RS09005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS09010	COG0372	Belongs to the citrate synthase family
L1857_RS09015	COG0372	Belongs to the citrate synthase family
L1857_RS09025	COG0583	DNA-binding transcription factor activity
L1857_RS09035	COG0129	dihydroxy-acid dehydratase activity
L1857_RS09060	COG4336	lyase activity
L1857_RS09100	COG4977	sequence-specific DNA binding
L1857_RS09125	COG3285	dna ligase
L1857_RS09125	COG1793	dna ligase
L1857_RS09140	COG1063	alcohol dehydrogenase
L1857_RS09150	COG1280	lysine exporter protein (LysE YggA)
L1857_RS09175	COG0564	pseudouridine synthase activity
L1857_RS09200	COG3226	Transcriptional regulator
L1857_RS09225	COG2186	Transcriptional regulator
L1857_RS09275	COG1725	Transcriptional regulator
L1857_RS09305	COG0018	arginyl-trna synthetase
L1857_RS09310	COG0019	diaminopimelate decarboxylase activity
L1857_RS09315	COG0460	homoserine dehydrogenase
L1857_RS09320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L1857_RS09325	COG0083	homoserine kinase activity
L1857_RS09340	COG0254	rRNA binding
L1857_RS09345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L1857_RS09350	COG0596	Alpha beta hydrolase
L1857_RS09355	COG0789	Transcriptional regulator
L1857_RS09360	COG2890	protein-(glutamine-N5) methyltransferase activity
L1857_RS09370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L1857_RS09380	COG0356	it plays a direct role in the translocation of protons across the membrane
L1857_RS09385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1857_RS09390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L1857_RS09395	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L1857_RS09400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L1857_RS09405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L1857_RS09410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L1857_RS09415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L1857_RS09440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L1857_RS09450	COG1280	lysine exporter protein (LysE YggA)
L1857_RS09455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L1857_RS09455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L1857_RS09465	COG0765	amino acid transport
L1857_RS09470	COG0765	amino acid transport
L1857_RS09475	COG1126	abc transporter atp-binding protein
L1857_RS09485	COG1024	Enoyl-CoA hydratase
L1857_RS09500	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
L1857_RS09520	COG2376	Dihydroxyacetone kinase
L1857_RS09545	COG1309	transcriptional regulator
L1857_RS09570	COG2267	carboxylic ester hydrolase activity
L1857_RS09585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L1857_RS09620	COG1335	isochorismatase
L1857_RS09625	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L1857_RS09630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L1857_RS09640	COG3191	aminopeptidase activity
L1857_RS09675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L1857_RS09680	COG1234	tRNA 3'-trailer cleavage
L1857_RS09700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L1857_RS09705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L1857_RS09710	COG1984	allophanate hydrolase subunit 2
L1857_RS09715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L1857_RS09720	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L1857_RS09755	COG0300	oxidoreductase activity
L1857_RS09810	COG0110	maltose O-acetyltransferase activity
L1857_RS09820	COG0431	NADPH-dependent FMN reductase
L1857_RS09835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L1857_RS09865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L1857_RS09885	COG1307	EDD domain protein, DegV family
L1857_RS09895	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L1857_RS09925	COG0482	sulfurtransferase activity
L1857_RS09960	COG0640	Transcriptional regulator
L1857_RS10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_RS10020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L1857_RS10050	COG2409	Drug exporters of the RND superfamily
L1857_RS10060	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L1857_RS10100	COG2259	Doxx family
L1857_RS10105	COG0129	dihydroxy-acid dehydratase activity
L1857_RS10110	COG2186	Transcriptional regulator
L1857_RS10115	COG0154	amidase activity
L1857_RS10135	COG0440	acetolactate synthase activity
L1857_RS10140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L1857_RS10165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1857_RS10170	COG1404	Belongs to the peptidase S8 family
L1857_RS10175	COG0473	3-isopropylmalate dehydrogenase activity
L1857_RS10180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_RS10195	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_RS10205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L1857_RS10260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1857_RS10265	COG0066	3-isopropylmalate dehydratase activity
L1857_RS10280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L1857_RS10295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1857_RS10320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_RS10325	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1857_RS10350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L1857_RS10355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L1857_RS10360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L1857_RS10365	COG1461	Dihydroxyacetone kinase
L1857_RS10380	COG3800	Transcriptional regulator
L1857_RS10380	COG1396	sequence-specific DNA binding
L1857_RS10395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1857_RS10400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS10405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_RS10410	COG3973	AAA domain
L1857_RS10415	COG0742	ribosomal rna small subunit methyltransferase
L1857_RS10420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L1857_RS10440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L1857_RS10445	COG0571	ribonuclease III activity
L1857_RS10450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1857_RS10455	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L1857_RS10470	COG0367	asparagine synthase
L1857_RS10480	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L1857_RS10485	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L1857_RS10490	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
L1857_RS10515	COG1254	Belongs to the acylphosphatase family
L1857_RS10535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_RS10540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L1857_RS10580	COG1414	Transcriptional regulator
L1857_RS10585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L1857_RS10600	COG3835	regulator
L1857_RS10620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_RS10630	COG1309	transcriptional regulator
L1857_RS10640	COG2233	PERMEase
L1857_RS10665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1857_RS10670	COG4266	Belongs to the allantoicase family
L1857_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS10690	COG2873	o-acetylhomoserine
L1857_RS10700	COG0477	Major facilitator Superfamily
L1857_RS10725	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
L1857_RS10735	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L1857_RS10780	COG0228	four-way junction DNA binding
L1857_RS10795	COG0336	Belongs to the RNA methyltransferase TrmD family
L1857_RS10800	COG0335	large ribosomal subunit rRNA binding
L1857_RS10805	COG0681	Belongs to the peptidase S26 family
L1857_RS10810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L1857_RS10820	COG0792	nuclease activity
L1857_RS10845	COG1191	sigma factor activity
L1857_RS10855	COG0052	Belongs to the universal ribosomal protein uS2 family
L1857_RS10860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L1857_RS10865	COG0528	UMP kinase activity
L1857_RS10870	COG0233	cytoplasmic translational termination
L1857_RS10885	COG2226	methyltransferase
L1857_RS10895	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L1857_RS10905	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L1857_RS10910	COG0750	zinc metalloprotease
L1857_RS10915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L1857_RS10945	COG2186	Transcriptional regulator
L1857_RS10950	COG2807	transmembrane transport
L1857_RS10995	COG0513	Belongs to the DEAD box helicase family
L1857_RS11005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_RS11010	COG3022	response to hydroperoxide
L1857_RS11025	COG3903	Transcriptional regulator
L1857_RS11025	COG3629	intracellular signal transduction
L1857_RS11050	COG1609	Transcriptional regulator
L1857_RS11055	COG2223	nitrite transmembrane transporter activity
L1857_RS11080	COG2902	Dehydrogenase
L1857_RS11095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS11105	COG0668	transmembrane transport
L1857_RS11120	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L1857_RS11130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L1857_RS11160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1857_RS11175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L1857_RS11195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1857_RS11200	COG1793	dna ligase
L1857_RS11200	COG3285	dna ligase
L1857_RS11220	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS11240	COG0395	ABC-type sugar transport system, permease component
L1857_RS11270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L1857_RS11275	COG2205	protein histidine kinase activity
L1857_RS11305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L1857_RS11310	COG0544	peptidyl-prolyl cis-trans isomerase activity
L1857_RS11315	COG0740	serine-type endopeptidase activity
L1857_RS11320	COG0740	serine-type endopeptidase activity
L1857_RS11325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L1857_RS11340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS11345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L1857_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS11385	COG2353	YceI-like domain
L1857_RS11390	COG0346	lactoylglutathione lyase activity
L1857_RS11405	COG0477	Major facilitator Superfamily
L1857_RS11425	COG0525	valine-tRNA ligase activity
L1857_RS11430	COG2318	DinB family
L1857_RS11450	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS11460	COG2755	lipolytic protein G-D-S-L family
L1857_RS11465	COG1960	acyl-CoA dehydrogenase activity
L1857_RS11470	COG0154	amidase activity
L1857_RS11485	COG0285	dihydrofolate synthase activity
L1857_RS11505	COG0105	UTP biosynthetic process
L1857_RS11510	COG1414	Transcriptional regulator
L1857_RS11515	COG1131	(ABC) transporter
L1857_RS11535	COG1530	ribonuclease E activity
L1857_RS11535	COG1530	ribonuclease E activity
L1857_RS11540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L1857_RS11545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L1857_RS11550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L1857_RS11560	COG0477	Major facilitator Superfamily
L1857_RS11565	COG0514	ATP-dependent DNA helicase (RecQ)
L1857_RS11570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L1857_RS11575	COG0799	negative regulation of ribosome biogenesis
L1857_RS11585	COG2755	lipolytic protein G-D-S-L family
L1857_RS11590	COG1307	EDD domain protein, DegV family
L1857_RS11595	COG1596	polysaccharide export
L1857_RS11595	COG1555	photosystem II stabilization
L1857_RS11605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L1857_RS11615	COG0268	Binds directly to 16S ribosomal RNA
L1857_RS11630	COG2226	methyltransferase
L1857_RS11660	COG2070	2-Nitropropane dioxygenase
L1857_RS11675	COG3328	transposase activity
L1857_RS11705	COG5183	chlorophyll binding
L1857_RS11705	COG2133	pyrroloquinoline quinone binding
L1857_RS11725	COG5183	chlorophyll binding
L1857_RS11725	COG2133	pyrroloquinoline quinone binding
L1857_RS11770	COG0531	amino acid
L1857_RS11785	COG0604	alcohol dehydrogenase
L1857_RS11800	COG2732	(Barnase) inhibitor
L1857_RS11805	COG1024	Enoyl-CoA hydratase
L1857_RS11830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1857_RS11840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1857_RS11865	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1857_RS11905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS11910	COG3104	oligopeptide transport
L1857_RS11925	COG0477	Major facilitator Superfamily
L1857_RS11930	COG1309	transcriptional regulator
L1857_RS11935	COG0367	asparagine synthase
L1857_RS11940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS11950	COG3976	FMN-binding domain protein
L1857_RS11950	COG1053	succinate dehydrogenase
L1857_RS11955	COG0395	ABC-type sugar transport system, permease component
L1857_RS11995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1857_RS12005	COG1953	Uracil, thiamine, allantoin
L1857_RS12020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1857_RS12035	COG0484	heat shock protein binding
L1857_RS12045	COG0537	adenosine 5'-monophosphoramidase activity
L1857_RS12055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L1857_RS12070	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L1857_RS12085	COG1381	Involved in DNA repair and RecF pathway recombination
L1857_RS12090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L1857_RS12100	COG0701	Predicted permease
L1857_RS12125	COG0423	glycine-tRNA ligase activity
L1857_RS12135	COG1396	sequence-specific DNA binding
L1857_RS12140	COG1131	(ABC) transporter
L1857_RS12150	COG4585	Histidine kinase
L1857_RS12155	COG2197	response regulator
L1857_RS12180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L1857_RS12185	COG0789	Transcriptional regulator
L1857_RS12195	COG1595	DNA-templated transcription, initiation
L1857_RS12200	COG0358	DNA primase activity
L1857_RS12210	COG4106	trans-aconitate 2-methyltransferase activity
L1857_RS12215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L1857_RS12235	COG0582	viral genome integration into host DNA
L1857_RS12305	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS12335	COG0410	ABC transporter
L1857_RS12370	COG3467	pyridoxamine 5'-phosphate
L1857_RS12390	COG1234	tRNA 3'-trailer cleavage
L1857_RS12420	COG0124	histidyl-tRNA synthetase
L1857_RS12435	COG0596	Alpha beta hydrolase
L1857_RS12440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_RS12445	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1857_RS12450	COG2080	2 iron, 2 sulfur cluster binding
L1857_RS12465	COG1802	Transcriptional regulator
L1857_RS12475	COG1454	alcohol dehydrogenase
L1857_RS12485	COG0277	FAD linked oxidase domain protein
L1857_RS12485	COG0247	lactate metabolic process
L1857_RS12490	COG2318	DinB family
L1857_RS12500	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS12510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_RS12525	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS12530	COG0183	Belongs to the thiolase family
L1857_RS12535	COG1960	acyl-CoA dehydrogenase activity
L1857_RS12540	COG1960	acyl-CoA dehydrogenase activity
L1857_RS12545	COG1024	Enoyl-CoA hydratase
L1857_RS12550	COG1024	Enoyl-CoA hydratase
L1857_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS12560	COG1960	acyl-CoA dehydrogenase activity
L1857_RS12590	COG0009	L-threonylcarbamoyladenylate synthase
L1857_RS12595	COG4221	oxidoreductase activity
L1857_RS12610	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS12695	COG2186	Transcriptional regulator
L1857_RS12705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L1857_RS12725	COG1309	transcriptional regulator
L1857_RS12755	COG4565	transcriptional regulatory protein
L1857_RS12760	COG3290	protein histidine kinase activity
L1857_RS12785	COG0702	epimerase
L1857_RS12795	COG1309	transcriptional regulator
L1857_RS12800	COG0791	NLP P60 protein
L1857_RS12805	COG1984	allophanate hydrolase subunit 2
L1857_RS12815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1857_RS12840	COG1674	ftsk spoiiie
L1857_RS12945	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS12950	COG0477	Major facilitator Superfamily
L1857_RS12955	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS12970	COG0747	negative chemotaxis
L1857_RS13010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_RS13015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1857_RS13060	COG3629	intracellular signal transduction
L1857_RS13060	COG3903	Transcriptional regulator
L1857_RS13065	COG3903	Transcriptional regulator
L1857_RS13065	COG3629	intracellular signal transduction
L1857_RS13070	COG2197	response regulator
L1857_RS13075	COG3903	Transcriptional regulator
L1857_RS13075	COG3629	intracellular signal transduction
L1857_RS13090	COG0671	phosphoesterase, PA-phosphatase related
L1857_RS13120	COG1595	DNA-templated transcription, initiation
L1857_RS13150	COG2011	ABC-type metal ion transport system permease component
L1857_RS13155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1857_RS13160	COG1464	Belongs to the NlpA lipoprotein family
L1857_RS13195	COG1609	Transcriptional regulator
L1857_RS13200	COG1129	ABC transporter
L1857_RS13205	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_RS13210	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_RS13230	COG3347	Dehydrogenase
L1857_RS13230	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS13240	COG1070	Carbohydrate kinase
L1857_RS13245	COG0247	lactate metabolic process
L1857_RS13250	COG1139	Iron-sulfur cluster binding protein
L1857_RS13255	COG1556	Lactate utilization protein
L1857_RS13260	COG2197	response regulator
L1857_RS13270	COG2132	Multicopper oxidase
L1857_RS13275	COG2132	Multicopper oxidase
L1857_RS13340	COG4974	Belongs to the 'phage' integrase family
L1857_RS13345	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS13355	COG1733	regulation of RNA biosynthetic process
L1857_RS13370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1857_RS13380	COG0789	Transcriptional regulator
L1857_RS13385	COG2814	Major facilitator Superfamily
L1857_RS13390	COG2814	Major facilitator Superfamily
L1857_RS13435	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS13445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1857_RS13450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1857_RS13455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1857_RS13465	COG1129	ABC transporter
L1857_RS13475	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_RS13485	COG4214	carbohydrate transport
L1857_RS13495	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS13535	COG2801	Transposase and inactivated derivatives
L1857_RS13545	COG4829	muconolactone delta-isomerase
L1857_RS13550	COG3485	protocatechuate 3,4-dioxygenase
L1857_RS13560	COG0583	DNA-binding transcription factor activity
L1857_RS13565	COG4638	Rieske (2fe-2S)
L1857_RS13585	COG2814	Major facilitator Superfamily
L1857_RS13595	COG3135	benzoate transporter
L1857_RS13610	COG3285	dna ligase
L1857_RS13610	COG1793	dna ligase
L1857_RS13615	COG0477	Major facilitator Superfamily
L1857_RS13625	COG0028	Belongs to the TPP enzyme family
L1857_RS13640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1857_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS13690	COG0515	serine threonine protein kinase
L1857_RS13720	COG0673	inositol 2-dehydrogenase activity
L1857_RS13735	COG0405	Gamma-glutamyltransferase
L1857_RS13755	COG1120	ATPase activity
L1857_RS13765	COG0803	Belongs to the bacterial solute-binding protein 9 family
L1857_RS13765	COG3443	Belongs to the bacterial solute-binding protein 9 family
L1857_RS13800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1857_RS13805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_RS13810	COG2814	Major facilitator Superfamily
L1857_RS13840	COG0702	epimerase
L1857_RS13855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L1857_RS13860	COG2218	PFAM glutamate synthase alpha subunit domain protein
L1857_RS13865	COG0069	glutamate synthase activity
L1857_RS13880	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L1857_RS13885	COG1024	Enoyl-CoA hydratase
L1857_RS13890	COG0584	glycerophosphoryl diester phosphodiesterase
L1857_RS13910	COG0477	Major facilitator Superfamily
L1857_RS13920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L1857_RS13925	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS13945	COG0477	Major facilitator Superfamily
L1857_RS13960	COG2376	Dihydroxyacetone kinase
L1857_RS13965	COG0698	ribose 5-phosphate isomerase
L1857_RS13975	COG3959	Transketolase, thiamine diphosphate binding domain
L1857_RS13980	COG3958	Transketolase
L1857_RS13985	COG2197	response regulator
L1857_RS13990	COG0477	Major facilitator Superfamily
L1857_RS13995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_RS14000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS14010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS14055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_RS14060	COG2188	Transcriptional regulator
L1857_RS14100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1857_RS14110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS14115	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_RS14135	COG2367	Beta-lactamase
L1857_RS14210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1857_RS14225	COG0477	Major facilitator Superfamily
L1857_RS14235	COG2072	flavoprotein involved in K transport
L1857_RS14245	COG4585	Histidine kinase
L1857_RS14250	COG2197	response regulator
L1857_RS14255	COG4152	abc transporter atp-binding protein
L1857_RS14285	COG0583	DNA-binding transcription factor activity
L1857_RS14305	COG3622	Belongs to the hyi family
L1857_RS14370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS14385	COG1309	transcriptional regulator
L1857_RS14395	COG0488	(ABC) transporter
L1857_RS14400	COG3540	Alkaline phosphatase
L1857_RS14420	COG0604	alcohol dehydrogenase
L1857_RS14420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1857_RS14420	COG3321	synthase
L1857_RS14420	COG4221	oxidoreductase activity
L1857_RS14425	COG1595	DNA-templated transcription, initiation
L1857_RS14440	COG0488	(ABC) transporter
L1857_RS14475	COG0604	alcohol dehydrogenase
L1857_RS14505	COG2084	Dehydrogenase
L1857_RS14515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1857_RS14520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_RS14550	COG0861	Integral membrane protein TerC family
L1857_RS14560	COG0477	Major facilitator Superfamily
L1857_RS14570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L1857_RS14575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1857_RS14580	COG1609	Transcriptional regulator
L1857_RS14595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L1857_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS14615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L1857_RS14640	COG1454	alcohol dehydrogenase
L1857_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS14675	COG0477	Major facilitator Superfamily
L1857_RS14680	COG0640	Transcriptional regulator
L1857_RS14700	COG1960	acyl-CoA dehydrogenase activity
L1857_RS14705	COG1309	transcriptional regulator
L1857_RS14710	COG0477	Major facilitator Superfamily
L1857_RS14725	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS14765	COG2814	Major facilitator Superfamily
L1857_RS14790	COG0745	RESPONSE REGULATOR receiver
L1857_RS14795	COG5002	protein histidine kinase activity
L1857_RS14840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L1857_RS14840	COG0646	methionine synthase
L1857_RS14850	COG0402	S-adenosylhomocysteine deaminase activity
L1857_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS14910	COG1309	transcriptional regulator
L1857_RS14950	COG0779	Required for maturation of 30S ribosomal subunits
L1857_RS14965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L1857_RS14965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L1857_RS14975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L1857_RS14990	COG0300	oxidoreductase activity
L1857_RS15010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L1857_RS15025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L1857_RS15045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L1857_RS15050	COG1185	polyribonucleotide nucleotidyltransferase activity
L1857_RS15060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L1857_RS15075	COG0667	Aldo Keto reductase
L1857_RS15105	COG3214	Protein conserved in bacteria
L1857_RS15150	COG0515	serine threonine protein kinase
L1857_RS15155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_RS15160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L1857_RS15190	COG0655	NAD(P)H dehydrogenase (quinone) activity
L1857_RS15215	COG1674	ftsk spoiiie
L1857_RS15225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L1857_RS15230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L1857_RS15240	COG1058	Belongs to the CinA family
L1857_RS15240	COG1546	Belongs to the CinA family
L1857_RS15245	COG1396	sequence-specific DNA binding
L1857_RS15250	COG1842	Phage shock protein A
L1857_RS15260	COG0167	dihydroorotate dehydrogenase activity
L1857_RS15280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1857_RS15295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1857_RS15305	COG2814	Major facilitator Superfamily
L1857_RS15315	COG1609	Transcriptional regulator
L1857_RS15325	COG0366	Alpha amylase catalytic
L1857_RS15335	COG1305	Transglutaminase-like
L1857_RS15345	COG0714	Associated with various cellular activities
L1857_RS15370	COG2001	Belongs to the MraZ family
L1857_RS15375	COG0275	rRNA processing
L1857_RS15385	COG0768	penicillin binding
L1857_RS15390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L1857_RS15400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L1857_RS15405	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L1857_RS15415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L1857_RS15420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L1857_RS15425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L1857_RS15455	COG1799	cell septum assembly
L1857_RS15475	COG0640	Transcriptional regulator
L1857_RS15480	COG0477	Major facilitator Superfamily
L1857_RS15485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L1857_RS15500	COG3263	regulation of cellular component size
L1857_RS15505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L1857_RS15510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L1857_RS15540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS15550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L1857_RS15570	COG0640	Transcriptional regulator
L1857_RS15590	COG0542	response to heat
L1857_RS15610	COG0438	transferase activity, transferring glycosyl groups
L1857_RS15615	COG3546	catalase activity
L1857_RS15630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L1857_RS15635	COG2192	nodulation
L1857_RS15640	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L1857_RS15645	COG0859	PFAM glycosyl transferase family 9
L1857_RS15650	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L1857_RS15655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L1857_RS15655	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L1857_RS15665	COG0859	PFAM glycosyl transferase family 9
L1857_RS15670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L1857_RS15730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L1857_RS15745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1857_RS15750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L1857_RS15780	COG2186	Transcriptional regulator
L1857_RS15785	COG3386	PFAM SMP-30 Gluconolaconase
L1857_RS15805	COG1316	TRANSCRIPTIONal
L1857_RS15825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L1857_RS15825	COG0237	dephospho-CoA kinase activity
L1857_RS15840	COG2197	response regulator
L1857_RS15855	COG1131	(ABC) transporter
L1857_RS15890	COG1131	(ABC) transporter
L1857_RS15900	COG0823	Involved in the tonB-independent uptake of proteins
L1857_RS15900	COG1506	peptidase
L1857_RS15900	COG4946	Tricorn protease homolog
L1857_RS15920	COG1129	ABC transporter
L1857_RS15925	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_RS15935	COG1609	Transcriptional regulator
L1857_RS15940	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
L1857_RS15945	COG1070	Carbohydrate kinase
L1857_RS15950	COG1285	pathogenesis
L1857_RS15985	COG0328	RNA-DNA hybrid ribonuclease activity
L1857_RS15995	COG1864	DNA RNA non-specific endonuclease
L1857_RS15995	COG3591	Belongs to the peptidase S1B family
L1857_RS16045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_RS16065	COG1301	dicarboxylic acid transport
L1857_RS16070	COG3290	protein histidine kinase activity
L1857_RS16075	COG4565	transcriptional regulatory protein
L1857_RS16085	COG2610	gluconate transmembrane transporter activity
L1857_RS16090	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
L1857_RS16105	COG0251	oxidation-reduction process
L1857_RS16120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L1857_RS16125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L1857_RS16130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_RS16135	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L1857_RS16140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1857_RS16140	COG0072	phenylalanine-tRNA ligase activity
L1857_RS16165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L1857_RS16170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L1857_RS16175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L1857_RS16180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1857_RS16185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L1857_RS16190	COG1438	arginine binding
L1857_RS16195	COG0165	Argininosuccinate lyase
L1857_RS16205	COG2094	Belongs to the DNA glycosylase MPG family
L1857_RS16210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L1857_RS16235	COG0647	UMP catabolic process
L1857_RS16250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1857_RS16280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L1857_RS16285	COG0504	CTP synthase activity
L1857_RS16290	COG0494	nUDIX hydrolase
L1857_RS16310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L1857_RS16315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L1857_RS16325	COG0514	ATP-dependent DNA helicase (RecQ)
L1857_RS16335	COG0475	glutathione-regulated potassium exporter activity
L1857_RS16355	COG1160	GTP binding
L1857_RS16375	COG4213	ABC transporter substrate-binding protein
L1857_RS16385	COG4214	carbohydrate transport
L1857_RS16400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_RS16410	COG0747	negative chemotaxis
L1857_RS16475	COG2851	Citrate transporter
L1857_RS16505	COG0577	efflux transmembrane transporter activity
L1857_RS16505	COG1136	(ABC) transporter
L1857_RS16510	COG4591	ABC-type transport system involved in lipoprotein release permease component
L1857_RS16515	COG2124	cytochrome p450
L1857_RS16525	COG1414	Transcriptional regulator
L1857_RS16530	COG0745	RESPONSE REGULATOR receiver
L1857_RS16540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1857_RS16545	COG1116	anion transmembrane transporter activity
L1857_RS16550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L1857_RS16555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS16560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L1857_RS16565	COG0506	proline dehydrogenase activity
L1857_RS16570	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS16585	COG1309	transcriptional regulator
L1857_RS16590	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L1857_RS16595	COG3281	Trehalose synthase
L1857_RS16600	COG0366	Alpha amylase catalytic
L1857_RS16605	COG0366	Alpha amylase catalytic
L1857_RS16650	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS16675	COG2843	Capsule synthesis protein
L1857_RS16690	COG1940	carbohydrate kinase activity
L1857_RS16700	COG1129	ABC transporter
L1857_RS16705	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_RS16710	COG1879	ABC-type sugar transport system periplasmic component
L1857_RS16725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L1857_RS16755	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L1857_RS16770	COG1268	BioY protein
L1857_RS16785	COG1122	ATPase activity
L1857_RS16805	COG0142	geranyltranstransferase activity
L1857_RS16815	COG4585	Histidine kinase
L1857_RS16850	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_RS16850	COG1024	Enoyl-CoA hydratase
L1857_RS16855	COG1063	alcohol dehydrogenase
L1857_RS16860	COG1410	methionine synthase
L1857_RS16860	COG0646	methionine synthase
L1857_RS16890	COG2115	Belongs to the xylose isomerase family
L1857_RS16895	COG3842	ATPase activity
L1857_RS16900	COG1940	carbohydrate kinase activity
L1857_RS16915	COG0246	Mannitol dehydrogenase
L1857_RS16920	COG0477	Major facilitator Superfamily
L1857_RS16925	COG1063	alcohol dehydrogenase
L1857_RS16935	COG0800	Aldolase
L1857_RS16940	COG0604	alcohol dehydrogenase
L1857_RS16955	COG1802	Transcriptional regulator
L1857_RS16985	COG1595	DNA-templated transcription, initiation
L1857_RS17025	COG0583	DNA-binding transcription factor activity
L1857_RS17030	COG1280	lysine exporter protein (LysE YggA)
L1857_RS17065	COG1414	Transcriptional regulator
L1857_RS17090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L1857_RS17125	COG0110	maltose O-acetyltransferase activity
L1857_RS17140	COG1215	transferase activity, transferring glycosyl groups
L1857_RS17150	COG0778	Nitroreductase
L1857_RS17170	COG1846	Transcriptional regulator
L1857_RS17180	COG1560	Kdo2-lipid A biosynthetic process
L1857_RS17185	COG0438	transferase activity, transferring glycosyl groups
L1857_RS17195	COG3608	succinylglutamate desuccinylase aspartoacylase
L1857_RS17195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L1857_RS17210	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L1857_RS17215	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
L1857_RS17220	COG0217	transcriptional regulatory protein
L1857_RS17230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L1857_RS17235	COG0632	four-way junction helicase activity
L1857_RS17240	COG2255	four-way junction helicase activity
L1857_RS17255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L1857_RS17260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L1857_RS17265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L1857_RS17270	COG1024	Enoyl-CoA hydratase
L1857_RS17310	COG1653	transport
L1857_RS17325	COG4977	sequence-specific DNA binding
L1857_RS17335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L1857_RS17345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L1857_RS17360	COG2040	homocysteine
L1857_RS17370	COG2124	cytochrome p450
L1857_RS17400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
L1857_RS17410	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS17450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS17455	COG1120	ATPase activity
L1857_RS17470	COG2264	protein methyltransferase activity
L1857_RS17510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1857_RS17515	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS17520	COG0596	Alpha beta hydrolase
L1857_RS17535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS17545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1857_RS17550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L1857_RS17555	COG3833	ABC-type maltose transport systems, permease component
L1857_RS17565	COG3842	ATPase activity
L1857_RS17575	COG1408	metallophosphoesterase
L1857_RS17585	COG2814	Major facilitator Superfamily
L1857_RS17605	COG1064	alcohol dehydrogenase
L1857_RS17615	COG0477	Major facilitator Superfamily
L1857_RS17700	COG4941	Belongs to the sigma-70 factor family
L1857_RS17715	COG1309	transcriptional regulator
L1857_RS17720	COG1511	domain protein
L1857_RS17735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L1857_RS17740	COG0539	negative regulation of cytoplasmic translation
L1857_RS17750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1857_RS17785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS17795	COG2211	Major facilitator Superfamily
L1857_RS17805	COG0523	cobalamin synthesis protein
L1857_RS17825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L1857_RS17835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L1857_RS17840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L1857_RS17850	COG1648	precorrin-2 dehydrogenase activity
L1857_RS17850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L1857_RS17865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_RS17890	COG1716	ATPase activity
L1857_RS17945	COG3572	ergothioneine biosynthetic process
L1857_RS17950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L1857_RS17955	COG0121	glutamine amidotransferase
L1857_RS17960	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
L1857_RS17990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L1857_RS17995	COG0492	ferredoxin-NADP+ reductase activity
L1857_RS18000	COG1309	transcriptional regulator
L1857_RS18005	COG0183	Belongs to the thiolase family
L1857_RS18010	COG3104	oligopeptide transport
L1857_RS18030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L1857_RS18035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L1857_RS18045	COG1414	Transcriptional regulator
L1857_RS18050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L1857_RS18070	COG0110	maltose O-acetyltransferase activity
L1857_RS18085	COG0640	Transcriptional regulator
L1857_RS18130	COG0477	Major facilitator Superfamily
L1857_RS18140	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS18160	COG0513	Belongs to the DEAD box helicase family
L1857_RS18175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS18185	COG0022	dehydrogenase e1 component
L1857_RS18190	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_RS18205	COG2197	response regulator
L1857_RS18210	COG4585	Histidine kinase
L1857_RS18235	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
L1857_RS18240	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L1857_RS18260	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L1857_RS18295	COG0477	Major facilitator Superfamily
L1857_RS18345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L1857_RS18350	COG0129	dihydroxy-acid dehydratase activity
L1857_RS18370	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_RS18390	COG4948	Mandelate Racemase Muconate Lactonizing
L1857_RS18395	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_RS18425	COG0583	DNA-binding transcription factor activity
L1857_RS18450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_RS18450	COG2010	Cytochrome c
L1857_RS18455	COG2080	2 iron, 2 sulfur cluster binding
L1857_RS18475	COG3226	Transcriptional regulator
L1857_RS18480	COG2814	Major facilitator Superfamily
L1857_RS18490	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_RS18490	COG1024	Enoyl-CoA hydratase
L1857_RS18505	COG0477	Major facilitator Superfamily
L1857_RS18515	COG4566	intracellular signal transduction
L1857_RS18560	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS18570	COG3958	Transketolase
L1857_RS18575	COG3959	Transketolase, thiamine diphosphate binding domain
L1857_RS18580	COG1414	Transcriptional regulator
L1857_RS18585	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS18590	COG1879	ABC-type sugar transport system periplasmic component
L1857_RS18595	COG1129	ABC transporter
L1857_RS18600	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_RS18610	COG2072	flavoprotein involved in K transport
L1857_RS18645	COG0745	RESPONSE REGULATOR receiver
L1857_RS18650	COG0745	RESPONSE REGULATOR receiver
L1857_RS18655	COG2205	protein histidine kinase activity
L1857_RS18665	COG0714	Associated with various cellular activities
L1857_RS18710	COG3547	Transposase (IS116 IS110 IS902 family)
L1857_RS18725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1857_RS18755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L1857_RS18760	COG1674	ftsk spoiiie
L1857_RS18805	COG2072	flavoprotein involved in K transport
L1857_RS18810	COG0583	DNA-binding transcription factor activity
L1857_RS18835	COG1309	transcriptional regulator
L1857_RS18845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_RS18850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1857_RS18855	COG2080	2 iron, 2 sulfur cluster binding
L1857_RS18860	COG1309	transcriptional regulator
L1857_RS18885	COG0659	secondary active sulfate transmembrane transporter activity
L1857_RS18925	COG0673	inositol 2-dehydrogenase activity
L1857_RS18955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L1857_RS18975	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS18985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS18995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
L1857_RS19025	COG3250	beta-galactosidase activity
L1857_RS19035	COG1609	Transcriptional regulator
L1857_RS19045	COG0148	phosphopyruvate hydratase activity
L1857_RS19055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1857_RS19060	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_RS19090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS19095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS19100	COG0477	Major facilitator Superfamily
L1857_RS19105	COG0477	Major facilitator Superfamily
L1857_RS19165	COG1960	acyl-CoA dehydrogenase activity
L1857_RS19180	COG1278	Cold shock
L1857_RS19185	COG3328	transposase activity
L1857_RS19220	COG0659	secondary active sulfate transmembrane transporter activity
L1857_RS19225	COG3973	AAA domain
L1857_RS19245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L1857_RS19265	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L1857_RS19270	COG0789	Transcriptional regulator
L1857_RS19290	COG1309	transcriptional regulator
L1857_RS19295	COG3328	transposase activity
L1857_RS19325	COG0640	Transcriptional regulator
L1857_RS19330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1857_RS19340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1857_RS19355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L1857_RS19360	COG0573	inorganic phosphate transmembrane transporter activity
L1857_RS19365	COG0581	inorganic phosphate transmembrane transporter activity
L1857_RS19370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L1857_RS19375	COG0745	RESPONSE REGULATOR receiver
L1857_RS19380	COG0640	Transcriptional regulator
L1857_RS19390	COG0798	PFAM Bile acid sodium symporter
L1857_RS19395	COG2072	flavoprotein involved in K transport
L1857_RS19400	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1857_RS19440	COG0697	spore germination
L1857_RS19500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1857_RS19510	COG3209	COG3209 Rhs family protein
L1857_RS19530	COG1846	Transcriptional regulator
L1857_RS19540	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L1857_RS19560	COG2072	flavoprotein involved in K transport
L1857_RS19595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L1857_RS19610	COG0431	NADPH-dependent FMN reductase
L1857_RS19615	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS19625	COG0656	L-ascorbic acid biosynthetic process
L1857_RS19655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1857_RS19715	COG0437	4 iron, 4 sulfur cluster binding
L1857_RS19725	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1857_RS19745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS19765	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS19780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_RS19800	COG0667	Aldo Keto reductase
L1857_RS19805	COG1968	undecaprenyl-diphosphatase activity
L1857_RS19815	COG0339	signal peptide processing
L1857_RS19820	COG2226	methyltransferase
L1857_RS19830	COG0154	amidase activity
L1857_RS19850	COG1846	Transcriptional regulator
L1857_RS19875	COG0039	L-malate dehydrogenase activity
L1857_RS19915	COG0601	transmembrane transport
L1857_RS19920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L1857_RS19925	COG4172	Belongs to the ABC transporter superfamily
L1857_RS19945	COG1619	proteins homologs of microcin C7 resistance protein MccF
L1857_RS19965	COG1595	DNA-templated transcription, initiation
L1857_RS20010	COG1733	regulation of RNA biosynthetic process
L1857_RS20065	COG0477	Major facilitator Superfamily
L1857_RS20075	COG1595	DNA-templated transcription, initiation
L1857_RS20105	COG0300	oxidoreductase activity
L1857_RS20130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_RS20140	COG0477	Major facilitator Superfamily
L1857_RS20145	COG3976	FMN-binding domain protein
L1857_RS20145	COG1053	succinate dehydrogenase
L1857_RS20150	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS20155	COG1802	Transcriptional regulator
L1857_RS20175	COG2860	membrane
L1857_RS20200	COG0583	DNA-binding transcription factor activity
L1857_RS20215	COG2890	protein-(glutamine-N5) methyltransferase activity
L1857_RS20220	COG1802	Transcriptional regulator
L1857_RS20270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L1857_RS20305	COG1435	thymidine kinase activity
L1857_RS20315	COG0463	Glycosyl transferase, family 2
L1857_RS20325	COG1228	amidohydrolase
L1857_RS20390	COG4152	abc transporter atp-binding protein
L1857_RS20450	COG2378	regulation of single-species biofilm formation
L1857_RS20455	COG2378	regulation of single-species biofilm formation
L1857_RS20470	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L1857_RS20475	COG1357	PFAM Pentapeptide repeats (8 copies)
L1857_RS20480	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L1857_RS20485	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
L1857_RS20525	COG1222	aaa ATPase
L1857_RS20545	COG0517	IMP dehydrogenase activity
L1857_RS20545	COG1994	Peptidase M50
L1857_RS20560	COG1192	Involved in chromosome partitioning
L1857_RS20565	COG2814	Major facilitator Superfamily
L1857_RS20575	COG4941	Belongs to the sigma-70 factor family
L1857_RS20580	COG3795	YCII-related domain
L1857_RS20595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L1857_RS20600	COG0140	phosphoribosyl-ATP diphosphatase activity
L1857_RS20610	COG1410	methionine synthase
L1857_RS20610	COG0646	methionine synthase
L1857_RS20625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L1857_RS20630	COG0488	(ABC) transporter
L1857_RS20635	COG0215	cysteine-tRNA ligase activity
L1857_RS20685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L1857_RS20690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L1857_RS20700	COG0477	Major facilitator Superfamily
L1857_RS20705	COG0745	RESPONSE REGULATOR receiver
L1857_RS20725	COG2226	methyltransferase
L1857_RS20730	COG3540	Alkaline phosphatase
L1857_RS20735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L1857_RS20745	COG2304	oxidoreductase activity
L1857_RS20755	COG0714	Associated with various cellular activities
L1857_RS20770	COG0746	molybdenum cofactor guanylyltransferase activity
L1857_RS20775	COG0596	Alpha beta hydrolase
L1857_RS20780	COG0791	NLP P60 protein
L1857_RS20780	COG3883	PFAM NLP P60 protein
L1857_RS20795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L1857_RS20800	COG0477	Major facilitator Superfamily
L1857_RS20815	COG2197	response regulator
L1857_RS20845	COG0589	response to stress
L1857_RS20850	COG2814	Major facilitator Superfamily
L1857_RS20855	COG1082	Xylose isomerase domain protein TIM barrel
L1857_RS20860	COG0673	inositol 2-dehydrogenase activity
L1857_RS20865	COG1082	Xylose isomerase domain protein TIM barrel
L1857_RS20875	COG3962	Belongs to the TPP enzyme family
L1857_RS20880	COG3718	enzyme involved in inositol metabolism
L1857_RS20890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1857_RS20895	COG1609	Transcriptional regulator
L1857_RS20910	COG0714	Associated with various cellular activities
L1857_RS20920	COG3552	Protein containing von Willebrand factor type A (VWA) domain
L1857_RS20925	COG0137	argininosuccinate synthase activity
L1857_RS20955	COG1802	Transcriptional regulator
L1857_RS20965	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
L1857_RS20970	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_RS20985	COG1414	Transcriptional regulator
L1857_RS20990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_RS20995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS21000	COG2610	gluconate transmembrane transporter activity
L1857_RS21010	COG3655	Transcriptional regulator
L1857_RS21015	COG2814	Major facilitator Superfamily
L1857_RS21070	COG2226	methyltransferase
L1857_RS21090	COG5479	isomerase activity
L1857_RS21090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L1857_RS21105	COG4941	Belongs to the sigma-70 factor family
L1857_RS21125	COG0640	Transcriptional regulator
L1857_RS21145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L1857_RS21160	COG1309	transcriptional regulator
L1857_RS21165	COG2267	carboxylic ester hydrolase activity
L1857_RS21170	COG2755	lipolytic protein G-D-S-L family
L1857_RS21180	COG1733	regulation of RNA biosynthetic process
L1857_RS21190	COG2814	Major facilitator Superfamily
L1857_RS21205	COG0251	oxidation-reduction process
L1857_RS21240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1857_RS21275	COG1846	Transcriptional regulator
L1857_RS21285	COG0477	Major facilitator Superfamily
L1857_RS21290	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS21315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1857_RS21320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L1857_RS21330	COG4948	Mandelate Racemase Muconate Lactonizing
L1857_RS21340	COG3250	beta-galactosidase activity
L1857_RS21345	COG1609	Transcriptional regulator
L1857_RS21350	COG1904	glucuronate isomerase
L1857_RS21355	COG0246	Mannitol dehydrogenase
L1857_RS21415	COG0596	Alpha beta hydrolase
L1857_RS21420	COG1335	isochorismatase
L1857_RS21445	COG0477	Major facilitator Superfamily
L1857_RS21460	COG2309	aminopeptidase activity
L1857_RS21470	COG1280	lysine exporter protein (LysE YggA)
L1857_RS21480	COG0596	Alpha beta hydrolase
L1857_RS21495	COG0583	DNA-binding transcription factor activity
L1857_RS21530	COG5280	Phage tail tape measure protein TP901
L1857_RS21530	COG3953	SLT domain
L1857_RS21550	COG0596	Alpha beta hydrolase
L1857_RS21585	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS21590	COG1024	Enoyl-CoA hydratase
L1857_RS21595	COG1960	acyl-CoA dehydrogenase activity
L1857_RS21605	COG1309	transcriptional regulator
L1857_RS21610	COG1739	Uncharacterized protein family UPF0029
L1857_RS21615	COG0009	L-threonylcarbamoyladenylate synthase
L1857_RS21645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_RS21655	COG0477	Major facilitator Superfamily
L1857_RS21660	COG1802	Transcriptional regulator
L1857_RS21670	COG1937	Protein conserved in bacteria
L1857_RS21700	COG0583	DNA-binding transcription factor activity
L1857_RS21705	COG1942	4-Oxalocrotonate Tautomerase
L1857_RS21710	COG2855	membrane
L1857_RS21725	COG0280	phosphate acetyltransferase
L1857_RS21735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_RS21750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_RS21765	COG1414	Transcriptional regulator
L1857_RS21775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1857_RS21780	COG1113	amino acid transport
L1857_RS21810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L1857_RS21815	COG0569	domain protein
L1857_RS21820	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L1857_RS21870	COG0025	NhaP-type Na H and K H
L1857_RS21875	COG1063	alcohol dehydrogenase
L1857_RS21880	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS21885	COG3387	PFAM Glycoside hydrolase 15-related
L1857_RS21895	COG1295	ribonuclease BN
L1857_RS21920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
L1857_RS21955	COG1957	nucleoside hydrolase
L1857_RS21995	COG0740	serine-type endopeptidase activity
L1857_RS22000	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS22020	COG1846	Transcriptional regulator
L1857_RS22055	COG0477	Major facilitator Superfamily
L1857_RS22060	COG3971	2-oxopent-4-enoate hydratase activity
L1857_RS22070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1857_RS22070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1857_RS22085	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS22090	COG1309	transcriptional regulator
L1857_RS22095	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS22100	COG0045	succinate-CoA ligase (ADP-forming) activity
L1857_RS22100	COG1042	CoA-binding domain protein
L1857_RS22100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L1857_RS22105	COG1960	acyl-CoA dehydrogenase activity
L1857_RS22115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L1857_RS22145	COG2197	response regulator
L1857_RS22150	COG4585	Histidine kinase
L1857_RS22165	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS22185	COG3835	regulator
L1857_RS22195	COG4266	Belongs to the allantoicase family
L1857_RS22200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1857_RS22205	COG1929	Belongs to the glycerate kinase type-1 family
L1857_RS22210	COG3960	tartronate-semialdehyde synthase activity
L1857_RS22215	COG2084	Dehydrogenase
L1857_RS22220	COG3622	Belongs to the hyi family
L1857_RS22230	COG2252	PERMEase
L1857_RS22235	COG0590	tRNA wobble adenosine to inosine editing
L1857_RS22240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_RS22260	COG2351	hydroxyisourate hydrolase activity
L1857_RS22270	COG3835	regulator
L1857_RS22295	COG0189	ligase activity
L1857_RS22355	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS22360	COG4221	oxidoreductase activity
L1857_RS22410	COG1846	Transcriptional regulator
L1857_RS22430	COG0492	ferredoxin-NADP+ reductase activity
L1857_RS22435	COG1247	-acetyltransferase
L1857_RS22440	COG0477	Major facilitator Superfamily
L1857_RS22455	COG1414	Transcriptional regulator
L1857_RS22460	COG2814	Major facilitator Superfamily
L1857_RS22485	COG3485	protocatechuate 3,4-dioxygenase
L1857_RS22490	COG1454	alcohol dehydrogenase
L1857_RS22495	COG2814	Major facilitator Superfamily
L1857_RS22505	COG0596	Alpha beta hydrolase
L1857_RS22535	COG0640	Transcriptional regulator
L1857_RS22565	COG1136	(ABC) transporter
L1857_RS22575	COG4585	Histidine kinase
L1857_RS22580	COG2197	response regulator
L1857_RS22605	COG0022	dehydrogenase e1 component
L1857_RS22610	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_RS22620	COG1940	carbohydrate kinase activity
L1857_RS22620	COG1846	Transcriptional regulator
L1857_RS22630	COG0183	Belongs to the thiolase family
L1857_RS22645	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS22650	COG1960	acyl-CoA dehydrogenase activity
L1857_RS22665	COG0280	phosphate acetyltransferase
L1857_RS22680	COG5416	Lipopolysaccharide assembly protein A domain
L1857_RS22710	COG1302	Protein conserved in bacteria
L1857_RS22730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS22750	COG0596	Alpha beta hydrolase
L1857_RS22770	COG1309	transcriptional regulator
L1857_RS22795	COG1063	alcohol dehydrogenase
L1857_RS22815	COG2318	DinB family
L1857_RS22820	COG1796	DNA polymerase
L1857_RS22820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L1857_RS22825	COG4941	Belongs to the sigma-70 factor family
L1857_RS22850	COG2259	Doxx family
L1857_RS22860	COG3209	COG3209 Rhs family protein
L1857_RS22890	COG5650	phosphatidylinositol metabolic process
L1857_RS22895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L1857_RS22930	COG1960	acyl-CoA dehydrogenase activity
L1857_RS22935	COG1960	acyl-CoA dehydrogenase activity
L1857_RS22940	COG1960	acyl-CoA dehydrogenase activity
L1857_RS22945	COG1309	transcriptional regulator
L1857_RS22955	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS22960	COG1309	transcriptional regulator
L1857_RS22965	COG0596	Alpha beta hydrolase
L1857_RS22995	COG1309	transcriptional regulator
L1857_RS23015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1857_RS23020	COG1960	acyl-CoA dehydrogenase activity
L1857_RS23035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_RS23035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L1857_RS23040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_RS23070	COG0657	acetylesterase activity
L1857_RS23085	COG1316	TRANSCRIPTIONal
L1857_RS23095	COG4821	SIS domain
L1857_RS23100	COG1132	(ABC) transporter
L1857_RS23115	COG0488	(ABC) transporter
L1857_RS23120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L1857_RS23125	COG4251	negative regulation of phosphorylation
L1857_RS23125	COG5001	Diguanylate cyclase
L1857_RS23125	COG3706	GGDEF domain
L1857_RS23125	COG2203	Gaf domain
L1857_RS23135	COG2151	metal-sulfur cluster biosynthetic enzyme
L1857_RS23140	COG0822	iron-sulfur transferase activity
L1857_RS23150	COG0396	ATPase activity
L1857_RS23210	COG3453	Protein conserved in bacteria
L1857_RS23210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_RS23215	COG2226	methyltransferase
L1857_RS23235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L1857_RS23240	COG1657	PFAM Prenyltransferase squalene oxidase
L1857_RS23250	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L1857_RS23280	COG0697	spore germination
L1857_RS23285	COG0300	oxidoreductase activity
L1857_RS23300	COG0109	protoheme IX farnesyltransferase activity
L1857_RS23310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L1857_RS23315	COG0166	Belongs to the GPI family
L1857_RS23330	COG0363	glucosamine-6-phosphate deaminase activity
L1857_RS23340	COG4585	Histidine kinase
L1857_RS23355	COG0149	triose-phosphate isomerase activity
L1857_RS23360	COG0126	phosphoglycerate kinase activity
L1857_RS23365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L1857_RS23410	COG1846	Transcriptional regulator
L1857_RS23435	COG2205	protein histidine kinase activity
L1857_RS23440	COG0745	RESPONSE REGULATOR receiver
L1857_RS23450	COG1481	regulation of sporulation
L1857_RS23460	COG1660	Displays ATPase and GTPase activities
L1857_RS23465	COG0322	excinuclease ABC activity
L1857_RS23480	COG0708	Exodeoxyribonuclease III
L1857_RS23490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L1857_RS23495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1857_RS23495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L1857_RS23520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L1857_RS23525	COG0405	Gamma-glutamyltransferase
L1857_RS23535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L1857_RS23545	COG1758	RNA polymerase activity
L1857_RS23550	COG0194	GDP metabolic process
L1857_RS23560	COG0284	orotidine-5'-phosphate decarboxylase activity
L1857_RS23570	COG0505	Belongs to the CarA family
L1857_RS23585	COG0540	Belongs to the ATCase OTCase family
L1857_RS23590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L1857_RS23600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L1857_RS23605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L1857_RS23625	COG0346	lactoylglutathione lyase activity
L1857_RS23630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L1857_RS23635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L1857_RS23640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L1857_RS23645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L1857_RS23685	COG2190	(PTS) system
L1857_RS23690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L1857_RS23695	COG2188	Transcriptional regulator
L1857_RS23700	COG1263	PTS System
L1857_RS23705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L1857_RS23730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L1857_RS23785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L1857_RS23800	COG1733	regulation of RNA biosynthetic process
L1857_RS23810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
L1857_RS23830	COG0702	epimerase
L1857_RS23835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS23850	COG0386	Belongs to the glutathione peroxidase family
L1857_RS23870	COG1252	NADH dehydrogenase
L1857_RS23875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1857_RS23885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
L1857_RS23890	COG1473	amidohydrolase
L1857_RS23920	COG1414	Transcriptional regulator
L1857_RS23950	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS23960	COG2814	Major facilitator Superfamily
L1857_RS23975	COG2018	Roadblock/LC7 domain
L1857_RS24020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1857_RS24025	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS24050	COG2197	response regulator
L1857_RS24070	COG0439	Biotin carboxylase
L1857_RS24075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS24085	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_RS24095	COG2814	Major facilitator Superfamily
L1857_RS24120	COG0477	Major facilitator Superfamily
L1857_RS24125	COG0583	DNA-binding transcription factor activity
L1857_RS24130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1857_RS24135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L1857_RS24140	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_RS24145	COG1960	acyl-CoA dehydrogenase activity
L1857_RS24175	COG1278	Cold shock
L1857_RS24180	COG1940	carbohydrate kinase activity
L1857_RS24185	COG0673	inositol 2-dehydrogenase activity
L1857_RS24210	COG0590	tRNA wobble adenosine to inosine editing
L1857_RS24220	COG1522	sequence-specific DNA binding
L1857_RS24245	COG1960	acyl-CoA dehydrogenase activity
L1857_RS24260	COG1802	Transcriptional regulator
L1857_RS24285	COG2376	Dihydroxyacetone kinase
L1857_RS24290	COG1414	Transcriptional regulator
L1857_RS24305	COG2197	response regulator
L1857_RS24335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS24365	COG0542	response to heat
L1857_RS24385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS24400	COG2226	methyltransferase
L1857_RS24420	COG0640	Transcriptional regulator
L1857_RS24425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L1857_RS24475	COG1316	TRANSCRIPTIONal
L1857_RS24500	COG2175	clavaminate synthase activity
L1857_RS24505	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
L1857_RS24510	COG3336	cytochrome c oxidase
L1857_RS24530	COG2318	DinB family
L1857_RS24535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L1857_RS24540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_RS24545	COG0765	amino acid transport
L1857_RS24620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1857_RS24635	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS24655	COG2272	Belongs to the type-B carboxylesterase lipase family
L1857_RS24685	COG4941	Belongs to the sigma-70 factor family
L1857_RS24690	COG3795	YCII-related domain
L1857_RS24730	COG4946	Tricorn protease homolog
L1857_RS24730	COG0823	Involved in the tonB-independent uptake of proteins
L1857_RS24730	COG1506	peptidase
L1857_RS24755	COG0697	spore germination
L1857_RS24760	COG0463	Glycosyl transferase, family 2
L1857_RS24795	COG1309	transcriptional regulator
L1857_RS24805	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS24840	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS24845	COG3622	Belongs to the hyi family
L1857_RS24850	COG1846	Transcriptional regulator
L1857_RS24855	COG0477	Major facilitator Superfamily
L1857_RS24860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS24870	COG2018	Roadblock/LC7 domain
L1857_RS24885	COG3033	Beta-eliminating lyase
L1857_RS24895	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS24900	COG1024	Enoyl-CoA hydratase
L1857_RS24905	COG0577	efflux transmembrane transporter activity
L1857_RS24905	COG1136	(ABC) transporter
L1857_RS24910	COG0577	efflux transmembrane transporter activity
L1857_RS24910	COG1136	(ABC) transporter
L1857_RS24930	COG0745	RESPONSE REGULATOR receiver
L1857_RS24935	COG2205	protein histidine kinase activity
L1857_RS24940	COG3012	SEC-C Motif Domain Protein
L1857_RS24955	COG0183	Belongs to the thiolase family
L1857_RS24975	COG2271	Major facilitator Superfamily
L1857_RS24980	COG0583	DNA-binding transcription factor activity
L1857_RS24990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_RS25005	COG3386	PFAM SMP-30 Gluconolaconase
L1857_RS25065	COG3835	regulator
L1857_RS25080	COG2271	Major facilitator Superfamily
L1857_RS25090	COG0657	acetylesterase activity
L1857_RS25095	COG1414	Transcriptional regulator
L1857_RS25100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS25105	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_RS25125	COG1414	Transcriptional regulator
L1857_RS25130	COG2814	Major facilitator Superfamily
L1857_RS25140	COG3250	beta-galactosidase activity
L1857_RS25145	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_RS25170	COG0673	inositol 2-dehydrogenase activity
L1857_RS25175	COG1063	alcohol dehydrogenase
L1857_RS25185	COG1136	(ABC) transporter
L1857_RS25190	COG0577	efflux transmembrane transporter activity
L1857_RS25190	COG1136	(ABC) transporter
L1857_RS25210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L1857_RS25215	COG0765	amino acid transport
L1857_RS25220	COG0765	amino acid transport
L1857_RS25225	COG1126	abc transporter atp-binding protein
L1857_RS25245	COG2267	carboxylic ester hydrolase activity
L1857_RS25265	COG0640	Transcriptional regulator
L1857_RS25270	COG0798	PFAM Bile acid sodium symporter
L1857_RS25275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L1857_RS25310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1857_RS25310	COG0426	domain, Protein
L1857_RS25315	COG1960	acyl-CoA dehydrogenase activity
L1857_RS25320	COG1960	acyl-CoA dehydrogenase activity
L1857_RS25325	COG1960	acyl-CoA dehydrogenase activity
L1857_RS25330	COG1024	Enoyl-CoA hydratase
L1857_RS25335	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS25340	COG1960	acyl-CoA dehydrogenase activity
L1857_RS25350	COG0183	Belongs to the thiolase family
L1857_RS25370	COG1024	Enoyl-CoA hydratase
L1857_RS25375	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS25390	COG0640	Transcriptional regulator
L1857_RS25395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L1857_RS25405	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_RS25405	COG1024	Enoyl-CoA hydratase
L1857_RS25460	COG2375	cellular response to nickel ion
L1857_RS25460	COG1132	(ABC) transporter
L1857_RS25465	COG1132	(ABC) transporter
L1857_RS25470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L1857_RS25475	COG4638	Rieske (2fe-2S)
L1857_RS25480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L1857_RS25515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L1857_RS25520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1857_RS25530	COG1760	l-serine dehydratase
L1857_RS25540	COG1414	Transcriptional regulator
L1857_RS25545	COG2146	nitrite reductase [NAD(P)H] activity
L1857_RS25555	COG3226	Transcriptional regulator
L1857_RS25560	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS25585	COG4977	sequence-specific DNA binding
L1857_RS25590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L1857_RS25595	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS25610	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L1857_RS25630	COG0574	Belongs to the PEP-utilizing enzyme family
L1857_RS25630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L1857_RS25710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS25730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_RS25740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1857_RS25800	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_RS25810	COG0154	amidase activity
L1857_RS25835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L1857_RS25840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1857_RS25845	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS25855	COG1735	metal-dependent hydrolase with the TIM-barrel fold
L1857_RS25865	COG2124	cytochrome p450
L1857_RS25900	COG0596	Alpha beta hydrolase
L1857_RS25925	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS25935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L1857_RS25940	COG4176	ABC-type proline glycine betaine transport system permease component
L1857_RS25945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L1857_RS25955	COG0066	3-isopropylmalate dehydratase activity
L1857_RS25960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L1857_RS25965	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L1857_RS25970	COG1414	Transcriptional regulator
L1857_RS25975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_RS26035	COG3883	PFAM NLP P60 protein
L1857_RS26035	COG0791	NLP P60 protein
L1857_RS26100	COG0714	Associated with various cellular activities
L1857_RS26265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1857_RS26265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1857_RS26325	COG4977	sequence-specific DNA binding
L1857_RS26335	COG0174	glutamine synthetase
L1857_RS26365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L1857_RS26380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L1857_RS26390	COG1793	dna ligase
L1857_RS26410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS26465	COG3253	May function as heme-dependent peroxidase
L1857_RS26475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L1857_RS26485	COG2197	response regulator
L1857_RS26495	COG0183	Belongs to the thiolase family
L1857_RS26500	COG1024	Enoyl-CoA hydratase
L1857_RS26500	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_RS26505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS26510	COG1846	Transcriptional regulator
L1857_RS26515	COG0656	L-ascorbic acid biosynthetic process
L1857_RS26520	COG2205	protein histidine kinase activity
L1857_RS26525	COG0745	RESPONSE REGULATOR receiver
L1857_RS26530	COG0583	DNA-binding transcription factor activity
L1857_RS26540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L1857_RS26555	COG1053	succinate dehydrogenase
L1857_RS26560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L1857_RS26570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L1857_RS26575	COG0531	amino acid
L1857_RS26580	COG0569	domain protein
L1857_RS26590	COG0596	Alpha beta hydrolase
L1857_RS26625	COG0756	dUTP diphosphatase activity
L1857_RS26645	COG0483	inositol monophosphate 1-phosphatase activity
L1857_RS26665	COG0531	amino acid
L1857_RS26675	COG0174	glutamine synthetase
L1857_RS26710	COG2313	pseudouridylate synthase activity
L1857_RS26725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L1857_RS26730	COG2318	DinB family
L1857_RS26745	COG1490	D-aminoacyl-tRNA deacylase activity
L1857_RS26770	COG3795	YCII-related domain
L1857_RS26775	COG4941	Belongs to the sigma-70 factor family
L1857_RS26790	COG2070	2-Nitropropane dioxygenase
L1857_RS26830	COG2124	cytochrome p450
L1857_RS26835	COG0183	Belongs to the thiolase family
L1857_RS26845	COG2226	methyltransferase
L1857_RS26855	COG0583	DNA-binding transcription factor activity
L1857_RS26860	COG1733	regulation of RNA biosynthetic process
L1857_RS26865	COG0702	epimerase
L1857_RS26880	COG1473	amidohydrolase
L1857_RS26890	COG0596	Alpha beta hydrolase
L1857_RS26910	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L1857_RS26915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_RS26925	COG0366	Alpha amylase catalytic
L1857_RS26930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L1857_RS26935	COG0346	lactoylglutathione lyase activity
L1857_RS26940	COG2267	carboxylic ester hydrolase activity
L1857_RS26945	COG1960	acyl-CoA dehydrogenase activity
L1857_RS26955	COG1053	succinate dehydrogenase
L1857_RS26975	COG2030	dehydratase
L1857_RS27000	COG1960	acyl-CoA dehydrogenase activity
L1857_RS27005	COG1960	acyl-CoA dehydrogenase activity
L1857_RS27010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L1857_RS27015	COG0657	acetylesterase activity
L1857_RS27025	COG1733	regulation of RNA biosynthetic process
L1857_RS27030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L1857_RS27035	COG1960	acyl-CoA dehydrogenase activity
L1857_RS27040	COG1309	transcriptional regulator
L1857_RS27060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L1857_RS27060	COG1703	isobutyryl-CoA mutase activity
L1857_RS27060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L1857_RS27075	COG2018	Roadblock/LC7 domain
L1857_RS27090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_RS27095	COG0019	diaminopimelate decarboxylase activity
L1857_RS27100	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L1857_RS27115	COG1566	PFAM secretion protein HlyD family protein
L1857_RS27135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS27150	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS27155	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L1857_RS27155	COG1672	PFAM Archaeal ATPase
L1857_RS27180	COG1946	Acyl-CoA thioesterase
L1857_RS27205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L1857_RS27215	COG0204	Acyl-transferase
L1857_RS27230	COG1929	Belongs to the glycerate kinase type-1 family
L1857_RS27235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_RS27245	COG1309	transcriptional regulator
L1857_RS27260	COG2890	protein-(glutamine-N5) methyltransferase activity
L1857_RS27280	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L1857_RS27285	COG0723	plastoquinol--plastocyanin reductase activity
L1857_RS27290	COG3328	transposase activity
L1857_RS27295	COG3328	transposase activity
L1857_RS27350	COG1278	Cold shock
L1857_RS27365	COG2080	2 iron, 2 sulfur cluster binding
L1857_RS27370	COG2010	Cytochrome c
L1857_RS27370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_RS27400	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1857_RS27400	COG1902	pentaerythritol trinitrate reductase activity
L1857_RS27405	COG1902	pentaerythritol trinitrate reductase activity
L1857_RS27405	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1857_RS27415	COG0535	radical SAM domain protein
L1857_RS27445	COG1940	carbohydrate kinase activity
L1857_RS27455	COG0003	Pfam Anion-transporting ATPase
L1857_RS27475	COG1022	Amp-dependent synthetase and ligase
L1857_RS27530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1857_RS27535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L1857_RS27545	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS27550	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS27560	COG1960	acyl-CoA dehydrogenase activity
L1857_RS27565	COG1960	acyl-CoA dehydrogenase activity
L1857_RS27570	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS27580	COG0123	including yeast histone deacetylase and acetoin utilization protein
L1857_RS27590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L1857_RS27595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L1857_RS27615	COG0516	GMP reductase activity
L1857_RS27615	COG0517	IMP dehydrogenase activity
L1857_RS27630	COG1505	serine-type exopeptidase activity
L1857_RS27635	COG0477	Major facilitator Superfamily
L1857_RS27650	COG0758	DNA mediated transformation
L1857_RS27660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_RS27665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L1857_RS27670	COG1388	LysM domain
L1857_RS27675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L1857_RS27685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L1857_RS27700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L1857_RS27705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L1857_RS27715	COG1196	nuclear chromosome segregation
L1857_RS27735	COG2814	Major facilitator Superfamily
L1857_RS27750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L1857_RS27760	COG1126	abc transporter atp-binding protein
L1857_RS27770	COG0765	amino acid transport
L1857_RS27775	COG0765	amino acid transport
L1857_RS27780	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
L1857_RS27785	COG3842	ATPase activity
L1857_RS27795	COG1175	transmembrane transport
L1857_RS27805	COG1940	carbohydrate kinase activity
L1857_RS27815	COG1053	succinate dehydrogenase
L1857_RS27835	COG0800	Aldolase
L1857_RS27845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_RS27865	COG2137	regulation of response to DNA damage stimulus
L1857_RS27870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L1857_RS27880	COG0443	Heat shock 70 kDa protein
L1857_RS27885	COG1201	RNA secondary structure unwinding
L1857_RS27890	COG0242	peptide deformylase activity
L1857_RS27920	COG5504	Zn-dependent protease
L1857_RS27940	COG0697	spore germination
L1857_RS27960	COG0583	DNA-binding transcription factor activity
L1857_RS27970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L1857_RS27975	COG1396	sequence-specific DNA binding
L1857_RS28025	COG3328	transposase activity
L1857_RS28040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_RS28045	COG0142	geranyltranstransferase activity
L1857_RS28075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
L1857_RS28080	COG2409	Drug exporters of the RND superfamily
L1857_RS28100	COG0067	glutamate synthase
L1857_RS28100	COG0070	glutamate synthase
L1857_RS28100	COG0069	glutamate synthase activity
L1857_RS28110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS28115	COG1120	ATPase activity
L1857_RS28145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L1857_RS28165	COG0159	tryptophan synthase activity
L1857_RS28170	COG0133	tryptophan synthase activity
L1857_RS28175	COG0134	indole-3-glycerol-phosphate synthase activity
L1857_RS28185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L1857_RS28195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L1857_RS28200	COG0107	imidazoleglycerol-phosphate synthase activity
L1857_RS28215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L1857_RS28220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L1857_RS28230	COG3958	Transketolase
L1857_RS28235	COG3959	Transketolase, thiamine diphosphate binding domain
L1857_RS28245	COG0456	acetyltransferase
L1857_RS28250	COG1309	transcriptional regulator
L1857_RS28255	COG2409	Drug exporters of the RND superfamily
L1857_RS28265	COG0131	Imidazoleglycerol-phosphate dehydratase
L1857_RS28270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L1857_RS28275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L1857_RS28290	COG2197	response regulator
L1857_RS28305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1857_RS28305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L1857_RS28325	COG0157	Belongs to the NadC ModD family
L1857_RS28330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L1857_RS28360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L1857_RS28370	COG0789	Transcriptional regulator
L1857_RS28380	COG2124	cytochrome p450
L1857_RS28395	COG0438	transferase activity, transferring glycosyl groups
L1857_RS28400	COG0791	NLP P60 protein
L1857_RS28425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L1857_RS28435	COG2010	Cytochrome c
L1857_RS28440	COG1845	cytochrome c oxidase, subunit III
L1857_RS28455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L1857_RS28465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L1857_RS28475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L1857_RS28495	COG0667	Aldo Keto reductase
L1857_RS28515	COG1228	amidohydrolase
L1857_RS28520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L1857_RS28540	COG1064	alcohol dehydrogenase
L1857_RS28550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L1857_RS28555	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_RS28570	COG1090	epimerase
L1857_RS28580	COG0321	lipoyl(octanoyl) transferase activity
L1857_RS28605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L1857_RS28610	COG0586	Pfam SNARE associated Golgi protein
L1857_RS28625	COG1752	Esterase of the alpha-beta hydrolase superfamily
L1857_RS28630	COG1376	ErfK ybiS ycfS ynhG family protein
L1857_RS28635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1857_RS28645	COG0587	DNA-directed DNA polymerase activity
L1857_RS28665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L1857_RS28685	COG4585	Histidine kinase
L1857_RS28690	COG2197	response regulator
L1857_RS28695	COG1472	Belongs to the glycosyl hydrolase 3 family
L1857_RS28705	COG1653	transport
L1857_RS28710	COG1175	transmembrane transport
L1857_RS28740	COG1397	ADP-ribosylglycohydrolase
L1857_RS28770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
L1857_RS28785	COG1620	l-lactate permease
L1857_RS28790	COG3201	nicotinamide mononucleotide transporter
L1857_RS28805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L1857_RS28810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L1857_RS28855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS28860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS28880	COG0442	prolyl-tRNA aminoacylation
L1857_RS28890	COG1414	Transcriptional regulator
L1857_RS28910	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L1857_RS28930	COG2186	Transcriptional regulator
L1857_RS28935	COG0028	Belongs to the TPP enzyme family
L1857_RS28940	COG1742	UPF0060 membrane protein
L1857_RS28945	COG0859	PFAM glycosyl transferase family 9
L1857_RS28955	COG1946	Acyl-CoA thioesterase
L1857_RS28985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L1857_RS28990	COG2151	metal-sulfur cluster biosynthetic enzyme
L1857_RS28995	COG3396	Phenylacetate-CoA oxygenase
L1857_RS29000	COG3460	Phenylacetate-CoA oxygenase
L1857_RS29005	COG3396	Phenylacetate-CoA oxygenase
L1857_RS29010	COG2030	dehydratase
L1857_RS29010	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS29030	COG1309	transcriptional regulator
L1857_RS29035	COG2814	Major facilitator Superfamily
L1857_RS29060	COG1690	Belongs to the RtcB family
L1857_RS29065	COG1522	sequence-specific DNA binding
L1857_RS29080	COG2226	methyltransferase
L1857_RS29095	COG2267	carboxylic ester hydrolase activity
L1857_RS29100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS29105	COG0789	Transcriptional regulator
L1857_RS29130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_RS29140	COG3285	dna ligase
L1857_RS29140	COG1793	dna ligase
L1857_RS29145	COG1672	PFAM Archaeal ATPase
L1857_RS29145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L1857_RS29150	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L1857_RS29160	COG3540	Alkaline phosphatase
L1857_RS29165	COG4941	Belongs to the sigma-70 factor family
L1857_RS29180	COG0477	Major facilitator Superfamily
L1857_RS29190	COG0242	peptide deformylase activity
L1857_RS29230	COG2315	Protein conserved in bacteria
L1857_RS29255	COG1846	Transcriptional regulator
L1857_RS29265	COG0477	Major facilitator Superfamily
L1857_RS29270	COG0596	Alpha beta hydrolase
L1857_RS29345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1857_RS29350	COG1414	Transcriptional regulator
L1857_RS29355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L1857_RS29405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS29415	COG0179	Fumarylacetoacetate (FAA) hydrolase
L1857_RS29420	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS29425	COG1506	peptidase
L1857_RS29425	COG0823	Involved in the tonB-independent uptake of proteins
L1857_RS29445	COG0604	alcohol dehydrogenase
L1857_RS29450	COG1733	regulation of RNA biosynthetic process
L1857_RS29495	COG3275	phosphorelay sensor kinase activity
L1857_RS29500	COG3279	Response regulator of the LytR AlgR family
L1857_RS29510	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_RS29520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L1857_RS29535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L1857_RS29540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
L1857_RS29545	COG2080	2 iron, 2 sulfur cluster binding
L1857_RS29555	COG2186	Transcriptional regulator
L1857_RS29560	COG0747	negative chemotaxis
L1857_RS29580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_RS29595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L1857_RS29605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L1857_RS29610	COG0531	amino acid
L1857_RS29635	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS29655	COG1609	Transcriptional regulator
L1857_RS29660	COG3328	transposase activity
L1857_RS29700	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS29710	COG1643	Atp-dependent helicase
L1857_RS29730	COG4978	Transcriptional regulator
L1857_RS29730	COG0789	Transcriptional regulator
L1857_RS29735	COG0475	glutathione-regulated potassium exporter activity
L1857_RS29745	COG2814	Major facilitator Superfamily
L1857_RS29770	COG0446	pyridine nucleotide-disulphide oxidoreductase
L1857_RS29785	COG1120	ATPase activity
L1857_RS29790	COG4122	O-methyltransferase activity
L1857_RS29800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L1857_RS29805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L1857_RS29810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1857_RS29810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L1857_RS29820	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
L1857_RS29825	COG0174	glutamine synthetase
L1857_RS29890	COG4106	trans-aconitate 2-methyltransferase activity
L1857_RS29895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L1857_RS29910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L1857_RS29915	COG1414	Transcriptional regulator
L1857_RS29920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1857_RS29925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1857_RS29935	COG3485	protocatechuate 3,4-dioxygenase
L1857_RS29940	COG3485	protocatechuate 3,4-dioxygenase
L1857_RS29945	COG0183	Belongs to the thiolase family
L1857_RS29950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L1857_RS29955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L1857_RS29975	COG1309	transcriptional regulator
L1857_RS29980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L1857_RS30020	COG3268	Saccharopine dehydrogenase
L1857_RS30050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1857_RS30055	COG0583	DNA-binding transcription factor activity
L1857_RS30080	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
L1857_RS30085	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L1857_RS30085	COG0235	Class ii aldolase
L1857_RS30105	COG2197	response regulator
L1857_RS30110	COG2197	response regulator
L1857_RS30115	COG0410	ABC transporter
L1857_RS30120	COG0411	ABC transporter
L1857_RS30125	COG0559	Belongs to the binding-protein-dependent transport system permease family
L1857_RS30145	COG1136	(ABC) transporter
L1857_RS30145	COG0577	efflux transmembrane transporter activity
L1857_RS30155	COG3971	2-oxopent-4-enoate hydratase activity
L1857_RS30175	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L1857_RS30180	COG0069	glutamate synthase activity
L1857_RS30180	COG0070	glutamate synthase
L1857_RS30180	COG0067	glutamate synthase
L1857_RS30195	COG1349	DNA-binding transcription factor activity
L1857_RS30200	COG1492	cobalamin metabolic process
L1857_RS30205	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
L1857_RS30220	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L1857_RS30240	COG1797	cobyrinic acid a,c-diamide synthase activity
L1857_RS30275	COG0778	Nitroreductase
L1857_RS30295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L1857_RS30300	COG1131	(ABC) transporter
L1857_RS30310	COG1476	TRANSCRIPTIONal
L1857_RS30320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L1857_RS30345	COG2183	response to ionizing radiation
L1857_RS30365	COG1522	sequence-specific DNA binding
L1857_RS30375	COG3328	transposase activity
L1857_RS30385	COG2910	NAD(P)H-binding
L1857_RS30390	COG0431	NADPH-dependent FMN reductase
L1857_RS30400	COG3328	transposase activity
L1857_RS30410	COG0277	FAD linked oxidase domain protein
L1857_RS30430	COG0515	serine threonine protein kinase
L1857_RS30430	COG2815	serine threonine protein kinase
L1857_RS30455	COG1119	ATPase activity
L1857_RS30485	COG0477	Major facilitator Superfamily
L1857_RS30500	COG4948	Mandelate Racemase Muconate Lactonizing
L1857_RS30505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L1857_RS30515	COG0058	SHG alpha-glucan phosphorylase activity
L1857_RS30525	COG1846	Transcriptional regulator
L1857_RS30540	COG2409	Drug exporters of the RND superfamily
L1857_RS30545	COG2205	protein histidine kinase activity
L1857_RS30550	COG0745	RESPONSE REGULATOR receiver
L1857_RS30575	COG1172	Belongs to the binding-protein-dependent transport system permease family
L1857_RS30580	COG1879	ABC-type sugar transport system periplasmic component
L1857_RS30585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L1857_RS30590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L1857_RS30595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_RS30605	COG0183	Belongs to the thiolase family
L1857_RS30640	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L1857_RS30650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L1857_RS30670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1857_RS30685	COG1376	ErfK ybiS ycfS ynhG family protein
L1857_RS30760	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_RS30780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_RS30785	COG1396	sequence-specific DNA binding
L1857_RS30850	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
L1857_RS30860	COG1414	Transcriptional regulator
L1857_RS30875	COG0784	Response regulator, receiver
L1857_RS30875	COG2205	protein histidine kinase activity
L1857_RS30895	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_RS30900	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_RS30905	COG2172	sigma factor antagonist activity
L1857_RS30925	COG1366	Belongs to the anti-sigma-factor antagonist family
L1857_RS30955	COG0517	IMP dehydrogenase activity
L1857_RS30985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L1857_RS30985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L1857_RS31005	COG1846	Transcriptional regulator
L1857_RS31050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L1857_RS31050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L1857_RS31085	COG0366	Alpha amylase catalytic
L1857_RS31120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L1857_RS31150	COG3844	kynureninase activity
L1857_RS31165	COG2814	Major facilitator Superfamily
L1857_RS31185	COG1316	TRANSCRIPTIONal
L1857_RS31200	COG1309	transcriptional regulator
L1857_RS31265	COG1595	DNA-templated transcription, initiation
L1857_RS31275	COG1082	Xylose isomerase domain protein TIM barrel
L1857_RS31275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L1857_RS31280	COG1309	transcriptional regulator
L1857_RS31285	COG0477	Major facilitator Superfamily
L1857_RS31310	COG0484	heat shock protein binding
L1857_RS31320	COG1396	sequence-specific DNA binding
L1857_RS31320	COG3800	Transcriptional regulator
L1857_RS31330	COG3340	Belongs to the peptidase S51 family
L1857_RS31335	COG0242	peptide deformylase activity
L1857_RS31360	COG1309	transcriptional regulator
L1857_RS31375	COG0596	Alpha beta hydrolase
L1857_RS31385	COG0477	Major facilitator Superfamily
L1857_RS31395	COG0655	NAD(P)H dehydrogenase (quinone) activity
L1857_RS31400	COG1063	alcohol dehydrogenase
L1857_RS31410	COG0435	Glutathione S-transferase
L1857_RS31420	COG0667	Aldo Keto reductase
L1857_RS31425	COG0154	amidase activity
L1857_RS31430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1857_RS31455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L1857_RS31460	COG0473	3-isopropylmalate dehydrogenase activity
L1857_RS31470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L1857_RS31485	COG0028	Belongs to the TPP enzyme family
L1857_RS31490	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_RS31490	COG1024	Enoyl-CoA hydratase
L1857_RS31495	COG0183	Belongs to the thiolase family
L1857_RS31500	COG1309	transcriptional regulator
L1857_RS31515	COG2409	Drug exporters of the RND superfamily
L1857_RS31520	COG1960	acyl-CoA dehydrogenase activity
L1857_RS31525	COG1960	acyl-CoA dehydrogenase activity
L1857_RS31550	COG0640	Transcriptional regulator
L1857_RS31555	COG0346	lactoylglutathione lyase activity
L1857_RS31585	COG1960	acyl-CoA dehydrogenase activity
L1857_RS31595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1857_RS31630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L1857_RS31645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L1857_RS31645	COG2508	Transcriptional regulator
L1857_RS31675	COG1132	(ABC) transporter
L1857_RS31680	COG0277	FAD linked oxidase domain protein
L1857_RS31690	COG3209	COG3209 Rhs family protein
L1857_RS31705	COG0567	Dehydrogenase, E1 component
L1857_RS31705	COG0508	dehydrogenase complex catalyzes the overall conversion of
L1857_RS31765	COG0406	alpha-ribazole phosphatase activity
L1857_RS31770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L1857_RS31785	COG1597	lipid kinase activity
L1857_RS31800	COG5662	AntiSigma factor
L1857_RS31810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L1857_RS31820	COG2135	peptidase activity
L1857_RS31840	COG0506	proline dehydrogenase activity
L1857_RS31840	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L1857_RS31840	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L1857_RS31855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_RS31860	COG1011	Hydrolase
L1857_RS31870	COG0653	protein targeting
L1857_RS31875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L1857_RS31890	COG0477	Major facilitator Superfamily
L1857_RS31900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L1857_RS31905	COG5401	PFAM Sporulation and spore germination
L1857_RS31910	COG5000	phosphorelay sensor kinase activity
L1857_RS31910	COG5002	protein histidine kinase activity
L1857_RS31915	COG0745	RESPONSE REGULATOR receiver
L1857_RS31935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L1857_RS31945	COG0531	amino acid
L1857_RS31970	COG1482	cell wall glycoprotein biosynthetic process
L1857_RS31980	COG2835	tetraacyldisaccharide 4'-kinase activity
L1857_RS31985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L1857_RS32010	COG1994	Peptidase M50
L1857_RS32025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_RS32030	COG0747	negative chemotaxis
L1857_RS32050	COG4608	Belongs to the ABC transporter superfamily
L1857_RS32055	COG0747	negative chemotaxis
L1857_RS32060	COG1217	gtp-binding protein TYPA
L1857_RS32080	COG0180	Tryptophanyl-tRNA synthetase
L1857_RS32090	COG2205	protein histidine kinase activity
L1857_RS32095	COG0745	RESPONSE REGULATOR receiver
L1857_RS32105	COG1131	(ABC) transporter
L1857_RS32115	COG3842	ATPase activity
L1857_RS32120	COG4149	molybdate abc transporter
L1857_RS32130	COG2154	pterin-4-alpha-carbinolamine dehydratase
L1857_RS32145	COG0012	GTP binding
L1857_RS32160	COG0419	ATPase involved in DNA repair
L1857_RS32165	COG0420	3'-5' exonuclease activity
L1857_RS32180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L1857_RS32190	COG1570	exodeoxyribonuclease VII activity
L1857_RS32200	COG1722	exodeoxyribonuclease VII activity
L1857_RS32215	COG0492	ferredoxin-NADP+ reductase activity
L1857_RS32220	COG0114	fumarate hydratase activity
L1857_RS32225	COG0667	Aldo Keto reductase
L1857_RS32245	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
L1857_RS32255	COG0697	spore germination
L1857_RS32260	COG1793	dna ligase
L1857_RS32270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS32275	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L1857_RS32295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L1857_RS32335	COG1331	Highly conserved protein containing a thioredoxin domain
L1857_RS32350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_RS32360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L1857_RS32365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L1857_RS32370	COG1522	sequence-specific DNA binding
L1857_RS32375	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L1857_RS32380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L1857_RS32420	COG0183	Belongs to the thiolase family
L1857_RS32450	COG0642	Histidine kinase
L1857_RS32490	COG3707	response regulator
L1857_RS32515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L1857_RS32525	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS32530	COG0477	Major facilitator Superfamily
L1857_RS32535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_RS32545	COG2409	Drug exporters of the RND superfamily
L1857_RS32555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L1857_RS32590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L1857_RS32600	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS32635	COG1252	NADH dehydrogenase
L1857_RS32685	COG0148	phosphopyruvate hydratase activity
L1857_RS32705	COG3956	TIGRFAM MazG family protein
L1857_RS32730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L1857_RS32750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1857_RS32755	COG2133	pyrroloquinoline quinone binding
L1857_RS32760	COG1113	amino acid transport
L1857_RS32785	COG2076	Multidrug Resistance protein
L1857_RS32815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
L1857_RS32840	COG0193	aminoacyl-tRNA hydrolase activity
L1857_RS32850	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS32870	COG1309	transcriptional regulator
L1857_RS32875	COG0488	(ABC) transporter
L1857_RS32880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L1857_RS32895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L1857_RS32900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L1857_RS32905	COG3583	domain protein
L1857_RS32910	COG0084	hydrolase, TatD family'
L1857_RS32915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L1857_RS32970	COG0515	serine threonine protein kinase
L1857_RS33015	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS33030	COG2217	Heavy metal translocating P-type atpase
L1857_RS33035	COG0640	Transcriptional regulator
L1857_RS33075	COG0745	RESPONSE REGULATOR receiver
L1857_RS33080	COG2205	protein histidine kinase activity
L1857_RS33085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L1857_RS33090	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
L1857_RS33095	COG1181	Belongs to the D-alanine--D-alanine ligase family
L1857_RS33130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L1857_RS33135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L1857_RS33160	COG0315	cyclic pyranopterin monophosphate synthase activity
L1857_RS33160	COG0521	Mo-molybdopterin cofactor biosynthetic process
L1857_RS33165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L1857_RS33175	COG1349	DNA-binding transcription factor activity
L1857_RS33180	COG2205	protein histidine kinase activity
L1857_RS33185	COG0745	RESPONSE REGULATOR receiver
L1857_RS33190	COG2197	response regulator
L1857_RS33220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L1857_RS33260	COG0387	Pfam Sodium calcium exchanger
L1857_RS33270	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS33315	COG0668	transmembrane transport
L1857_RS33320	COG1234	tRNA 3'-trailer cleavage
L1857_RS33330	COG1012	belongs to the aldehyde dehydrogenase family
L1857_RS33335	COG3795	YCII-related domain
L1857_RS33340	COG4941	Belongs to the sigma-70 factor family
L1857_RS33350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L1857_RS33365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L1857_RS33370	COG2267	carboxylic ester hydrolase activity
L1857_RS33395	COG0583	DNA-binding transcription factor activity
L1857_RS33400	COG2814	Major facilitator Superfamily
L1857_RS33405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L1857_RS33430	COG0583	DNA-binding transcription factor activity
L1857_RS33435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L1857_RS33445	COG1250	3-hydroxyacyl-CoA dehydrogenase
L1857_RS33450	COG1960	acyl-CoA dehydrogenase activity
L1857_RS33455	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L1857_RS33455	COG5479	isomerase activity
L1857_RS33465	COG1064	alcohol dehydrogenase
L1857_RS33470	COG1321	iron dependent repressor
L1857_RS33500	COG1024	Enoyl-CoA hydratase
L1857_RS33505	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS33510	COG1309	transcriptional regulator
L1857_RS33520	COG1960	acyl-CoA dehydrogenase activity
L1857_RS33530	COG2091	lysine biosynthetic process via aminoadipic acid
L1857_RS33535	COG1169	isochorismate synthase
L1857_RS33545	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS33580	COG4152	abc transporter atp-binding protein
L1857_RS33585	COG1668	transmembrane transport
L1857_RS33595	COG2801	Transposase and inactivated derivatives
L1857_RS33600	COG0415	Belongs to the DNA photolyase family
L1857_RS33615	COG1309	transcriptional regulator
L1857_RS33625	COG3328	transposase activity
L1857_RS33650	COG1960	acyl-CoA dehydrogenase activity
L1857_RS33655	COG1228	amidohydrolase
L1857_RS33665	COG2017	converts alpha-aldose to the beta-anomer
L1857_RS33670	COG1309	transcriptional regulator
L1857_RS33695	COG0259	pyridoxamine-phosphate oxidase activity
L1857_RS33700	COG0829	nickel cation binding
L1857_RS33705	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
L1857_RS33715	COG0804	urea catabolic process
L1857_RS33720	COG0832	Belongs to the urease beta subunit family
L1857_RS33725	COG0831	urea catabolic process
L1857_RS33755	COG5650	phosphatidylinositol metabolic process
L1857_RS33785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_RS33795	COG5398	heme oxygenase
L1857_RS33805	COG2162	N-hydroxyarylamine O-acetyltransferase activity
L1857_RS33815	COG2814	Major facilitator Superfamily
L1857_RS33835	COG2252	PERMEase
L1857_RS33860	COG2814	Major facilitator Superfamily
L1857_RS33870	COG1278	Cold shock
L1857_RS33880	COG0546	phosphoglycolate phosphatase activity
L1857_RS33890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L1857_RS33895	COG0318	PFAM AMP-dependent synthetase and ligase
L1857_RS33900	COG0384	phenazine biosynthesis protein PhzF
L1857_RS33905	COG3304	Inner membrane component domain
L1857_RS33925	COG2814	Major facilitator Superfamily
L1857_RS33960	COG1846	Transcriptional regulator
L1857_RS33975	COG1388	LysM domain
L1857_RS34020	COG2018	Roadblock/LC7 domain
L1857_RS34035	COG2018	Roadblock/LC7 domain
L1857_RS34045	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L1857_RS34050	COG0765	amino acid transport
L1857_RS34055	COG0765	amino acid transport
L1857_RS34075	COG1061	Type III restriction enzyme res subunit
L1857_RS34095	COG0693	protein deglycase activity
L1857_RS34105	COG1063	alcohol dehydrogenase
L1857_RS34110	COG4948	Mandelate Racemase Muconate Lactonizing
L1857_RS34130	COG0459	protein refolding
L1857_RS34140	COG1278	Cold shock
L1857_RS34160	COG0688	phosphatidylethanolamine metabolic process
L1857_RS34165	COG1183	phosphatidylcholine synthase activity
L1857_RS34185	COG1309	transcriptional regulator
L1857_RS34190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1857_RS34205	COG0242	peptide deformylase activity
L1857_RS34220	COG0596	Alpha beta hydrolase
L1857_RS34230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L1857_RS34250	COG2022	thiamine diphosphate biosynthetic process
L1857_RS34260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L1857_RS34260	COG2022	thiamine diphosphate biosynthetic process
L1857_RS34265	COG0352	thiamine-phosphate diphosphorylase activity
L1857_RS34270	COG3226	Transcriptional regulator
L1857_RS34285	COG2188	Transcriptional regulator
L1857_RS34290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L1857_RS34295	COG2971	BadF BadG BcrA BcrD
L1857_RS34305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L1857_RS34320	COG3629	intracellular signal transduction
L1857_RS34320	COG3903	Transcriptional regulator
L1857_RS34325	COG5285	phytanoyl-CoA dioxygenase
L1857_RS34330	COG1917	Cupin 2, conserved barrel domain protein
L1857_RS34340	COG0456	acetyltransferase
L1857_RS34380	COG0346	lactoylglutathione lyase activity
L1857_RS34415	COG0129	dihydroxy-acid dehydratase activity
L1857_RS34435	COG3276	selenocysteine insertion sequence binding
L1857_RS34450	COG0709	Synthesizes selenophosphate from selenide and ATP
L1857_RS34460	COG1832	CoA-binding protein
L1857_RS34465	COG1028	Short-chain dehydrogenase reductase Sdr
L1857_RS34470	COG3835	regulator
L1857_RS34475	COG0477	Major facilitator Superfamily
L1857_RS34500	COG2301	Belongs to the HpcH HpaI aldolase family
L1857_RS34575	COG0582	viral genome integration into host DNA
L1857_RS34600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L1857_RS34605	COG2847	Copper chaperone PCu(A)C
L1857_RS34610	COG1329	Transcriptional regulator
L1857_RS34615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L1857_RS34620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L1857_RS34625	COG0546	phosphoglycolate phosphatase activity
L1857_RS34630	COG0215	cysteine-tRNA ligase activity
L1857_RS34635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L1857_RS34665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L1857_RS34670	COG0698	ribose 5-phosphate isomerase
L1857_RS34675	COG2376	Dihydroxyacetone kinase
L1857_RS34680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L1857_RS34690	COG1349	DNA-binding transcription factor activity
L1857_RS34695	COG2814	Major facilitator Superfamily
L1857_RS34700	COG1070	Carbohydrate kinase
L1857_RS34710	COG4399	Belongs to the UPF0754 family
L1857_RS34715	COG4399	Belongs to the UPF0754 family
L1857_RS34725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L1857_RS34730	COG1121	(ABC) transporter
L1857_RS34740	COG1609	Transcriptional regulator
L1857_RS34750	COG1194	a g-specific adenine glycosylase
L1857_RS34755	COG0667	Aldo Keto reductase
L1857_RS34765	COG0596	Alpha beta hydrolase
L1857_RS34770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1857_RS34780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L1857_RS34795	COG0583	DNA-binding transcription factor activity
L1857_RS34820	COG0443	Heat shock 70 kDa protein
L1857_RS34825	COG0542	response to heat
L1857_RS34860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L1857_RS34865	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L1857_RS34895	COG0789	Transcriptional regulator
L1857_RS34910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L1857_RS34920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L1857_RS34950	COG0037	tRNA processing
L1857_RS34960	COG2027	D-alanyl-D-alanine carboxypeptidase
L1857_RS34965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L1857_RS34970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L1857_RS35015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L1857_RS35020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L1857_RS35035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L1857_RS35035	COG1754	DNA topoisomerase type I activity
L1857_RS35060	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L1857_RS35065	COG1205	dead DEAH box helicase
L1857_RS35065	COG1111	helicase
L1857_RS35115	COG1472	Belongs to the glycosyl hydrolase 3 family
L1857_RS35120	COG3876	Protein conserved in bacteria
L1857_RS35130	COG1737	Transcriptional regulator
L1857_RS35135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L1857_RS35145	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
L1857_RS35155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L1857_RS35180	COG0477	Major facilitator Superfamily
L1857_RS35190	COG4941	Belongs to the sigma-70 factor family
L1857_RS35210	COG3104	oligopeptide transport
L1857_RS35215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L1857_RS35225	COG2267	carboxylic ester hydrolase activity
L1857_RS35270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid