locus-tag	class	description
ANA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANA_RS00070	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ANA_RS00075	COG0668	transmembrane transport
ANA_RS00095	COG0784	Response regulator, receiver
ANA_RS00100	COG4245	von Willebrand factor, type A
ANA_RS00115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ANA_RS00120	COG0579	oxidoreductase
ANA_RS00125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ANA_RS00130	COG1216	Glycosyl transferase, family 2
ANA_RS00135	COG1216	Glycosyl transferase, family 2
ANA_RS00160	COG0489	protein tyrosine kinase activity
ANA_RS00175	COG1132	(ABC) transporter
ANA_RS00185	COG1216	Glycosyl transferase, family 2
ANA_RS00190	COG0438	transferase activity, transferring glycosyl groups
ANA_RS00225	COG3903	Transcriptional regulator
ANA_RS00225	COG2319	Wd-40 repeat
ANA_RS00230	COG2988	succinylglutamate desuccinylase activity
ANA_RS00235	COG0438	transferase activity, transferring glycosyl groups
ANA_RS00240	COG5433	transposase activity
ANA_RS00255	COG2319	Wd-40 repeat
ANA_RS00265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ANA_RS00270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANA_RS00285	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS00285	COG0515	serine threonine protein kinase
ANA_RS00300	COG2197	response regulator
ANA_RS00305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ANA_RS00315	COG5002	protein histidine kinase activity
ANA_RS00330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ANA_RS00370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ANA_RS00380	COG0390	transport system, permease component
ANA_RS00405	COG1012	belongs to the aldehyde dehydrogenase family
ANA_RS00410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ANA_RS00425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ANA_RS00430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ANA_RS00435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ANA_RS00440	COG0544	peptidyl-prolyl cis-trans isomerase activity
ANA_RS00445	COG0740	serine-type endopeptidase activity
ANA_RS00450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ANA_RS00465	COG0406	alpha-ribazole phosphatase activity
ANA_RS00475	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ANA_RS00500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ANA_RS00520	COG0802	atpase or kinase
ANA_RS00530	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ANA_RS00535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ANA_RS00540	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ANA_RS00550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ANA_RS00560	COG1175	transmembrane transport
ANA_RS00570	COG0426	domain, Protein
ANA_RS00570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ANA_RS00580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ANA_RS00580	COG0426	domain, Protein
ANA_RS00590	COG0724	RNA recognition motif
ANA_RS00595	COG2205	protein histidine kinase activity
ANA_RS00600	COG1505	serine-type exopeptidase activity
ANA_RS00605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANA_RS00610	COG0051	transcription antitermination factor activity, RNA binding
ANA_RS00615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANA_RS00620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANA_RS00625	COG0049	tRNA binding
ANA_RS00630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ANA_RS00635	COG0316	Belongs to the HesB IscA family
ANA_RS00650	COG0067	glutamate synthase
ANA_RS00650	COG0069	glutamate synthase activity
ANA_RS00650	COG0070	glutamate synthase
ANA_RS00665	COG0463	Glycosyl transferase, family 2
ANA_RS00670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANA_RS00695	COG0561	phosphatase activity
ANA_RS00715	COG0432	Pfam Uncharacterised protein family UPF0047
ANA_RS00720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANA_RS00730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ANA_RS00770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ANA_RS00770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ANA_RS00775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ANA_RS00800	COG0494	nUDIX hydrolase
ANA_RS00805	COG0534	Mate efflux family protein
ANA_RS00810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ANA_RS00815	COG1268	BioY protein
ANA_RS00820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ANA_RS00825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ANA_RS00845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ANA_RS00850	COG0601	transmembrane transport
ANA_RS00865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ANA_RS00905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ANA_RS00925	COG0601	transmembrane transport
ANA_RS00930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANA_RS00945	COG0432	Pfam Uncharacterised protein family UPF0047
ANA_RS00950	COG0745	RESPONSE REGULATOR receiver
ANA_RS00955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ANA_RS00960	COG1333	cytochrome c biogenesis protein
ANA_RS00965	COG4232	protein-disulfide reductase activity
ANA_RS00985	COG2166	iron-sulfur cluster assembly
ANA_RS01005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ANA_RS01035	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ANA_RS01045	COG0133	tryptophan synthase activity
ANA_RS01065	COG0023	Translation Initiation Factor
ANA_RS01120	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS01120	COG0515	serine threonine protein kinase
ANA_RS01130	COG1131	(ABC) transporter
ANA_RS01135	COG2319	Wd-40 repeat
ANA_RS01135	COG1672	PFAM Archaeal ATPase
ANA_RS01140	COG4251	negative regulation of phosphorylation
ANA_RS01140	COG3706	GGDEF domain
ANA_RS01140	COG2203	Gaf domain
ANA_RS01140	COG5001	Diguanylate cyclase
ANA_RS01150	COG1316	TRANSCRIPTIONal
ANA_RS01155	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS01160	COG0728	peptidoglycan biosynthetic process
ANA_RS01165	COG2239	Acts as a magnesium transporter
ANA_RS01175	COG0540	Belongs to the ATCase OTCase family
ANA_RS01195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ANA_RS01195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ANA_RS01200	COG0222	ribosome binding
ANA_RS01205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ANA_RS01210	COG0081	regulation of translation
ANA_RS01215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ANA_RS01220	COG0250	Participates in transcription elongation, termination and antitermination
ANA_RS01225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ANA_RS01235	COG0335	large ribosomal subunit rRNA binding
ANA_RS01240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ANA_RS01275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ANA_RS01300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANA_RS01305	COG0193	aminoacyl-tRNA hydrolase activity
ANA_RS01310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ANA_RS01315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ANA_RS01340	COG2205	protein histidine kinase activity
ANA_RS01380	COG1672	PFAM Archaeal ATPase
ANA_RS01380	COG2319	Wd-40 repeat
ANA_RS01405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANA_RS01410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ANA_RS01425	COG0697	spore germination
ANA_RS01430	COG0306	phosphate transporter
ANA_RS01435	COG2226	methyltransferase
ANA_RS01450	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS01450	COG0515	serine threonine protein kinase
ANA_RS01510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS01540	COG2361	Protein of unknown function DUF86
ANA_RS01560	COG0708	Exodeoxyribonuclease III
ANA_RS01585	COG0824	Thioesterase
ANA_RS01590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ANA_RS01595	COG0534	Mate efflux family protein
ANA_RS01600	COG0416	fatty acid biosynthetic process
ANA_RS01605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ANA_RS01610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANA_RS01635	COG0270	DNA (cytosine-5-)-methyltransferase activity
ANA_RS01645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ANA_RS01660	COG2204	response regulator
ANA_RS01690	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
ANA_RS01700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ANA_RS01740	COG0535	radical SAM domain protein
ANA_RS01775	COG0339	signal peptide processing
ANA_RS01800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANA_RS01810	COG3206	protein involved in exopolysaccharide biosynthesis
ANA_RS01810	COG0489	protein tyrosine kinase activity
ANA_RS01825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_RS01880	COG0360	Binds together with S18 to 16S ribosomal RNA
ANA_RS01900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ANA_RS01905	COG0606	chelatase, subunit chli
ANA_RS01925	COG0537	adenosine 5'-monophosphoramidase activity
ANA_RS01940	COG0724	RNA recognition motif
ANA_RS01945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ANA_RS01965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ANA_RS01970	COG3794	PFAM blue (type 1) copper domain protein
ANA_RS01975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANA_RS01995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANA_RS02000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ANA_RS02020	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ANA_RS02040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ANA_RS02050	COG1160	GTP binding
ANA_RS02065	COG0745	RESPONSE REGULATOR receiver
ANA_RS02070	COG0429	hydrolase of the alpha beta-hydrolase fold
ANA_RS02075	COG2091	lysine biosynthetic process via aminoadipic acid
ANA_RS02095	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ANA_RS02100	COG0047	phosphoribosylformylglycinamidine synthase activity
ANA_RS02110	COG4680	protein conserved in bacteria
ANA_RS02130	COG0312	modulator of DNA gyrase
ANA_RS02175	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS02180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ANA_RS02185	COG0673	inositol 2-dehydrogenase activity
ANA_RS02200	COG2211	Major facilitator Superfamily
ANA_RS02205	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
ANA_RS02210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ANA_RS02215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_RS02230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ANA_RS02250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANA_RS02260	COG1492	cobalamin metabolic process
ANA_RS02280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_RS02285	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS02305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANA_RS02325	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ANA_RS02350	COG0395	ABC-type sugar transport system, permease component
ANA_RS02365	COG3437	response regulator, receiver
ANA_RS02365	COG2205	protein histidine kinase activity
ANA_RS02365	COG3850	Histidine kinase
ANA_RS02365	COG4999	Histidine kinase
ANA_RS02375	COG0814	amino acid
ANA_RS02420	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
ANA_RS02435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANA_RS02440	COG0772	Belongs to the SEDS family
ANA_RS02445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ANA_RS02460	COG0154	amidase activity
ANA_RS02490	COG0587	DNA-directed DNA polymerase activity
ANA_RS02500	COG2274	protein secretion by the type I secretion system
ANA_RS02520	COG2203	Gaf domain
ANA_RS02525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANA_RS02550	COG2084	Dehydrogenase
ANA_RS02555	COG0629	single-stranded DNA binding
ANA_RS02570	COG1136	(ABC) transporter
ANA_RS02570	COG0577	efflux transmembrane transporter activity
ANA_RS02590	COG0564	pseudouridine synthase activity
ANA_RS02615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ANA_RS02620	COG3903	Transcriptional regulator
ANA_RS02620	COG2319	Wd-40 repeat
ANA_RS02675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ANA_RS02680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ANA_RS02710	COG1595	DNA-templated transcription, initiation
ANA_RS02715	COG1376	ErfK ybiS ycfS ynhG family protein
ANA_RS02715	COG1388	LysM domain
ANA_RS02725	COG0739	heme binding
ANA_RS02725	COG1196	nuclear chromosome segregation
ANA_RS02725	COG0741	lytic transglycosylase activity
ANA_RS02730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANA_RS02730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANA_RS02740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ANA_RS02755	COG1027	Aspartate ammonia-lyase
ANA_RS02760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_RS02775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ANA_RS02780	COG2890	protein-(glutamine-N5) methyltransferase activity
ANA_RS02805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ANA_RS02825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ANA_RS02840	COG0628	permease
ANA_RS02850	COG1316	TRANSCRIPTIONal
ANA_RS02860	COG0515	serine threonine protein kinase
ANA_RS02860	COG3266	domain, Protein
ANA_RS02905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ANA_RS02910	COG3536	Protein conserved in bacteria
ANA_RS02920	COG0138	bifunctional purine biosynthesis protein purh
ANA_RS02935	COG0095	Lipoate-protein ligase
ANA_RS02950	COG1196	nuclear chromosome segregation
ANA_RS02950	COG1674	ftsk spoiiie
ANA_RS02955	COG1192	Involved in chromosome partitioning
ANA_RS02975	COG2066	Belongs to the glutaminase family
ANA_RS02980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ANA_RS02985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ANA_RS02985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ANA_RS02990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ANA_RS03020	COG0723	plastoquinol--plastocyanin reductase activity
ANA_RS03025	COG3258	Cytochrome c
ANA_RS03030	COG0363	glucosamine-6-phosphate deaminase activity
ANA_RS03035	COG0577	efflux transmembrane transporter activity
ANA_RS03035	COG1136	(ABC) transporter
ANA_RS03055	COG3321	synthase
ANA_RS03055	COG0604	alcohol dehydrogenase
ANA_RS03055	COG3321	synthase
ANA_RS03055	COG0604	alcohol dehydrogenase
ANA_RS03065	COG2070	2-Nitropropane dioxygenase
ANA_RS03065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANA_RS03075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANA_RS03075	COG3320	Male sterility
ANA_RS03095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ANA_RS03100	COG1799	cell septum assembly
ANA_RS03105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ANA_RS03130	COG1160	GTP binding
ANA_RS03155	COG4581	dead DEAH box helicase
ANA_RS03165	COG3385	transposase activity
ANA_RS03170	COG1902	pentaerythritol trinitrate reductase activity
ANA_RS03175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ANA_RS03205	COG0308	aminopeptidase N
ANA_RS03210	COG0768	penicillin binding
ANA_RS03215	COG3842	ATPase activity
ANA_RS03220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ANA_RS03225	COG1176	ABC-type spermidine putrescine transport system, permease component I
ANA_RS03230	COG0673	inositol 2-dehydrogenase activity
ANA_RS03240	COG0497	DNA recombination
ANA_RS03245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ANA_RS03255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANA_RS03260	COG0583	DNA-binding transcription factor activity
ANA_RS03280	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS03305	COG1429	ligase activity, forming nitrogen-metal bonds
ANA_RS03385	COG0113	porphobilinogen synthase activity
ANA_RS03400	COG0678	peroxiredoxin activity
ANA_RS03435	COG0166	Belongs to the GPI family
ANA_RS03440	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ANA_RS03460	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS03465	COG1160	GTP binding
ANA_RS03475	COG5635	Nacht domain
ANA_RS03475	COG2319	Wd-40 repeat
ANA_RS03480	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ANA_RS03490	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ANA_RS03500	COG0501	Belongs to the peptidase M48B family
ANA_RS03515	COG0297	glycogen (starch) synthase activity
ANA_RS03530	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ANA_RS03535	COG3659	wide pore channel activity
ANA_RS03540	COG0803	Belongs to the bacterial solute-binding protein 9 family
ANA_RS03545	COG1121	(ABC) transporter
ANA_RS03555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ANA_RS03575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ANA_RS03605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ANA_RS03610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANA_RS03615	COG1218	3'(2'),5'-bisphosphate nucleotidase
ANA_RS03620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ANA_RS03635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_RS03650	COG1116	anion transmembrane transporter activity
ANA_RS03655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ANA_RS03655	COG1116	anion transmembrane transporter activity
ANA_RS03680	COG0515	serine threonine protein kinase
ANA_RS03685	COG0538	isocitrate dehydrogenase activity
ANA_RS03700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ANA_RS03720	COG0505	Belongs to the CarA family
ANA_RS03730	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ANA_RS03735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANA_RS03745	COG0596	Alpha beta hydrolase
ANA_RS03755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ANA_RS03755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANA_RS03760	COG2076	Multidrug Resistance protein
ANA_RS03770	COG0129	dihydroxy-acid dehydratase activity
ANA_RS03780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ANA_RS03800	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ANA_RS03825	COG0515	serine threonine protein kinase
ANA_RS03825	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS03835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ANA_RS03855	COG1530	ribonuclease E activity
ANA_RS03860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ANA_RS03870	COG0077	Prephenate dehydratase
ANA_RS03870	COG1605	Chorismate mutase
ANA_RS03885	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ANA_RS03890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ANA_RS03895	COG0742	ribosomal rna small subunit methyltransferase
ANA_RS03900	COG2010	Cytochrome c
ANA_RS03930	COG0653	protein targeting
ANA_RS03940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_RS03970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ANA_RS03975	COG0438	transferase activity, transferring glycosyl groups
ANA_RS03985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ANA_RS03990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANA_RS03995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ANA_RS04010	COG1002	Type II restriction enzyme, methylase subunits
ANA_RS04030	COG0745	RESPONSE REGULATOR receiver
ANA_RS04045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ANA_RS04055	COG0702	epimerase
ANA_RS04060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ANA_RS04075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS04080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS04090	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ANA_RS04135	COG2183	response to ionizing radiation
ANA_RS04150	COG1950	PFAM Membrane protein of
ANA_RS04170	COG2010	Cytochrome c
ANA_RS04205	COG3266	domain, Protein
ANA_RS04205	COG0515	serine threonine protein kinase
ANA_RS04260	COG3657	addiction module killer protein
ANA_RS04280	COG0159	tryptophan synthase activity
ANA_RS04300	COG4572	Cation transport regulator
ANA_RS04330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANA_RS04345	COG0656	L-ascorbic acid biosynthetic process
ANA_RS04370	COG0442	prolyl-tRNA aminoacylation
ANA_RS04395	COG5554	nitrogen fixation
ANA_RS04400	COG5554	nitrogen fixation
ANA_RS04405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANA_RS04420	COG1045	serine acetyltransferase
ANA_RS04435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ANA_RS04450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ANA_RS04460	COG0045	succinate-CoA ligase (ADP-forming) activity
ANA_RS04475	COG2217	Heavy metal translocating P-type atpase
ANA_RS04480	COG0123	including yeast histone deacetylase and acetoin utilization protein
ANA_RS04495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANA_RS04510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ANA_RS04520	COG0616	signal peptide processing
ANA_RS04560	COG0469	pyruvate kinase activity
ANA_RS04580	COG0484	heat shock protein binding
ANA_RS04590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANA_RS04610	COG4636	protein conserved in cyanobacteria
ANA_RS04660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ANA_RS04680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANA_RS04685	COG0398	Pfam SNARE associated Golgi protein
ANA_RS04705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ANA_RS04705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ANA_RS04745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ANA_RS04765	COG0748	coenzyme F420 binding
ANA_RS04780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANA_RS04795	COG0181	hydroxymethylbilane synthase activity
ANA_RS04805	COG0297	glycogen (starch) synthase activity
ANA_RS04820	COG4178	(ABC) transporter
ANA_RS04825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANA_RS04840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ANA_RS04845	COG3321	synthase
ANA_RS04845	COG0604	alcohol dehydrogenase
ANA_RS04880	COG4948	Mandelate Racemase Muconate Lactonizing
ANA_RS04895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ANA_RS04900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ANA_RS04920	COG3629	intracellular signal transduction
ANA_RS04920	COG3903	Transcriptional regulator
ANA_RS04930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ANA_RS04935	COG0745	RESPONSE REGULATOR receiver
ANA_RS04950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ANA_RS04960	COG3878	Protein conserved in bacteria
ANA_RS04975	COG3659	wide pore channel activity
ANA_RS04995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ANA_RS05000	COG1408	metallophosphoesterase
ANA_RS05015	COG0473	3-isopropylmalate dehydrogenase activity
ANA_RS05020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ANA_RS05060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANA_RS05065	COG4178	(ABC) transporter
ANA_RS05075	COG0436	Aminotransferase
ANA_RS05080	COG0463	Glycosyl transferase, family 2
ANA_RS05080	COG0457	Tetratricopeptide repeat
ANA_RS05085	COG0322	excinuclease ABC activity
ANA_RS05095	COG0217	transcriptional regulatory protein
ANA_RS05105	COG0837	glucose binding
ANA_RS05115	COG0436	Aminotransferase
ANA_RS05150	COG1252	NADH dehydrogenase
ANA_RS05155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ANA_RS05165	COG0154	amidase activity
ANA_RS05185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ANA_RS05245	COG0784	Response regulator, receiver
ANA_RS05250	COG0564	pseudouridine synthase activity
ANA_RS05265	COG0237	dephospho-CoA kinase activity
ANA_RS05270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ANA_RS05275	COG1413	lyase activity
ANA_RS05280	COG1413	lyase activity
ANA_RS05285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANA_RS05290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANA_RS05295	COG0237	dephospho-CoA kinase activity
ANA_RS05300	COG0237	dephospho-CoA kinase activity
ANA_RS05315	COG0121	glutamine amidotransferase
ANA_RS05320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ANA_RS05325	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ANA_RS05335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ANA_RS05340	COG4208	sulfate ABC transporter
ANA_RS05360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANA_RS05370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ANA_RS05375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ANA_RS05385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ANA_RS05385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANA_RS05400	COG1940	carbohydrate kinase activity
ANA_RS05430	COG2082	Precorrin-8x methylmutase
ANA_RS05445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ANA_RS05450	COG0443	Heat shock 70 kDa protein
ANA_RS05475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_RS05475	COG0515	serine threonine protein kinase
ANA_RS05505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANA_RS05530	COG3118	belongs to the thioredoxin family
ANA_RS05535	COG0516	GMP reductase activity
ANA_RS05560	COG0628	permease
ANA_RS05570	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS05590	COG0083	homoserine kinase activity
ANA_RS05600	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS05600	COG0515	serine threonine protein kinase
ANA_RS05605	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ANA_RS05610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ANA_RS05620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ANA_RS05625	COG0512	Glutamine amidotransferase of anthranilate synthase
ANA_RS05630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ANA_RS05640	COG0006	proline dipeptidase activity
ANA_RS05645	COG2319	Wd-40 repeat
ANA_RS05645	COG5635	Nacht domain
ANA_RS05655	COG0454	-acetyltransferase
ANA_RS05665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ANA_RS05685	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ANA_RS05705	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ANA_RS05720	COG0714	Associated with various cellular activities
ANA_RS05785	COG0322	excinuclease ABC activity
ANA_RS05795	COG0215	cysteine-tRNA ligase activity
ANA_RS05800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ANA_RS05805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANA_RS05815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANA_RS05820	COG0359	binds to the 23S rRNA
ANA_RS05825	COG0305	Participates in initiation and elongation during chromosome replication
ANA_RS05825	COG1372	Participates in initiation and elongation during chromosome replication
ANA_RS05870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS05890	COG0515	serine threonine protein kinase
ANA_RS05895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ANA_RS05900	COG1121	(ABC) transporter
ANA_RS05905	COG0803	Belongs to the bacterial solute-binding protein 9 family
ANA_RS05910	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ANA_RS05915	COG5398	heme oxygenase
ANA_RS05920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ANA_RS05930	COG1994	Peptidase M50
ANA_RS05930	COG0517	IMP dehydrogenase activity
ANA_RS05940	COG0135	phosphoribosylanthranilate isomerase activity
ANA_RS05945	COG0302	gtp cyclohydrolase
ANA_RS05950	COG0300	oxidoreductase activity
ANA_RS05955	COG0825	malonyl-CoA metabolic process
ANA_RS05960	COG5322	oxidoreductase activity
ANA_RS05965	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ANA_RS06000	COG2154	pterin-4-alpha-carbinolamine dehydratase
ANA_RS06010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ANA_RS06020	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ANA_RS06050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ANA_RS06060	COG0683	leucine binding
ANA_RS06080	COG0586	Pfam SNARE associated Golgi protein
ANA_RS06085	COG1132	(ABC) transporter
ANA_RS06110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ANA_RS06115	COG0254	rRNA binding
ANA_RS06120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ANA_RS06130	COG0101	tRNA pseudouridine synthase activity
ANA_RS06135	COG0203	ribosomal protein L17
ANA_RS06140	COG0202	RNA polymerase activity
ANA_RS06145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ANA_RS06150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ANA_RS06155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ANA_RS06160	COG0563	adenylate kinase activity
ANA_RS06165	COG0201	protein transport
ANA_RS06170	COG0200	Binds to the 23S rRNA
ANA_RS06175	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ANA_RS06180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ANA_RS06185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ANA_RS06190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ANA_RS06195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ANA_RS06200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ANA_RS06205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ANA_RS06210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ANA_RS06215	COG0255	Belongs to the universal ribosomal protein uL29 family
ANA_RS06220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ANA_RS06225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ANA_RS06230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ANA_RS06235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ANA_RS06240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ANA_RS06245	COG0089	rRNA binding
ANA_RS06250	COG0088	Forms part of the polypeptide exit tunnel
ANA_RS06255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ANA_RS06285	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ANA_RS06305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ANA_RS06320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ANA_RS06320	COG0617	tRNA 3'-terminal CCA addition
ANA_RS06320	COG0517	IMP dehydrogenase activity
ANA_RS06340	COG3937	granule-associated protein
ANA_RS06345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANA_RS06350	COG0631	protein serine/threonine phosphatase activity
ANA_RS06365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ANA_RS06370	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ANA_RS06380	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANA_RS06395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ANA_RS06400	COG1381	Involved in DNA repair and RecF pathway recombination
ANA_RS06410	COG0438	transferase activity, transferring glycosyl groups
ANA_RS06415	COG3631	Ketosteroid isomerase-related protein
ANA_RS06440	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ANA_RS06465	COG0539	negative regulation of cytoplasmic translation
ANA_RS06470	COG0412	Dienelactone hydrolase
ANA_RS06475	COG2188	Transcriptional regulator
ANA_RS06485	COG0483	inositol monophosphate 1-phosphatase activity
ANA_RS06495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANA_RS06515	COG1361	Conserved repeat domain
ANA_RS06530	COG0352	thiamine-phosphate diphosphorylase activity
ANA_RS06560	COG0501	Belongs to the peptidase M48B family
ANA_RS06565	COG0464	growth
ANA_RS06570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANA_RS06590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ANA_RS06605	COG1850	ribulose-bisphosphate carboxylase activity
ANA_RS06615	COG4451	ribulose bisphosphate carboxylase, small
ANA_RS06670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ANA_RS06675	COG0438	transferase activity, transferring glycosyl groups
ANA_RS06680	COG1177	transmembrane transport
ANA_RS06695	COG0436	Aminotransferase
ANA_RS06700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANA_RS06755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ANA_RS06755	COG0284	orotidine-5'-phosphate decarboxylase activity
ANA_RS06760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANA_RS06765	COG1104	cysteine desulfurase activity
ANA_RS06785	COG0312	modulator of DNA gyrase
ANA_RS06790	COG0312	modulator of DNA gyrase
ANA_RS06820	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ANA_RS06830	COG0009	L-threonylcarbamoyladenylate synthase
ANA_RS06845	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ANA_RS06860	COG2176	DNA-directed DNA polymerase activity
ANA_RS06880	COG0463	Glycosyl transferase, family 2
ANA_RS06905	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ANA_RS06920	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ANA_RS06930	COG0113	porphobilinogen synthase activity
ANA_RS06935	COG0523	cobalamin synthesis protein
ANA_RS06940	COG0302	gtp cyclohydrolase
ANA_RS06970	COG0408	coproporphyrinogen oxidase activity
ANA_RS07015	COG0582	viral genome integration into host DNA
ANA_RS07025	COG1943	Transposase
ANA_RS07085	COG2501	S4 domain
ANA_RS07095	COG0746	molybdenum cofactor guanylyltransferase activity
ANA_RS07135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ANA_RS07160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ANA_RS07170	COG2226	methyltransferase
ANA_RS07180	COG0375	protein maturation
ANA_RS07195	COG0409	Hydrogenase expression formation protein
ANA_RS07200	COG0298	carbon dioxide binding
ANA_RS07205	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ANA_RS07270	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS07275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANA_RS07300	COG0563	adenylate kinase activity
ANA_RS07305	COG3118	belongs to the thioredoxin family
ANA_RS07325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ANA_RS07330	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ANA_RS07345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ANA_RS07365	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_RS07390	COG0004	ammonium transporteR
ANA_RS07400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ANA_RS07410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS07415	COG1937	Protein conserved in bacteria
ANA_RS07435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ANA_RS07460	COG0024	Methionine aminopeptidase
ANA_RS07465	COG0673	inositol 2-dehydrogenase activity
ANA_RS07490	COG2385	sporulation resulting in formation of a cellular spore
ANA_RS07500	COG1366	Belongs to the anti-sigma-factor antagonist family
ANA_RS07505	COG0745	RESPONSE REGULATOR receiver
ANA_RS07525	COG0107	imidazoleglycerol-phosphate synthase activity
ANA_RS07530	COG2255	four-way junction helicase activity
ANA_RS07540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS07550	COG0515	serine threonine protein kinase
ANA_RS07550	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS07555	COG1366	Belongs to the anti-sigma-factor antagonist family
ANA_RS07560	COG0586	Pfam SNARE associated Golgi protein
ANA_RS07565	COG0137	argininosuccinate synthase activity
ANA_RS07570	COG0463	Glycosyl transferase, family 2
ANA_RS07600	COG0752	glycyl-tRNA synthetase alpha subunit
ANA_RS07620	COG1819	glycosyl
ANA_RS07625	COG2124	cytochrome p450
ANA_RS07650	COG2267	carboxylic ester hydrolase activity
ANA_RS07660	COG3266	domain, Protein
ANA_RS07660	COG0515	serine threonine protein kinase
ANA_RS07665	COG0515	serine threonine protein kinase
ANA_RS07665	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS07670	COG1073	alpha beta
ANA_RS07675	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
ANA_RS07680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ANA_RS07700	COG3266	domain, Protein
ANA_RS07700	COG0515	serine threonine protein kinase
ANA_RS07725	COG0024	Methionine aminopeptidase
ANA_RS07735	COG0612	Peptidase, M16
ANA_RS07760	COG0285	dihydrofolate synthase activity
ANA_RS07790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ANA_RS07795	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ANA_RS07800	COG1959	2 iron, 2 sulfur cluster binding
ANA_RS07815	COG0038	chloride channel
ANA_RS07825	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANA_RS07840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ANA_RS07845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ANA_RS07855	COG0473	3-isopropylmalate dehydrogenase activity
ANA_RS07860	COG1872	DUF167
ANA_RS07895	COG1473	amidohydrolase
ANA_RS07910	COG1136	(ABC) transporter
ANA_RS07920	COG0303	'Molybdopterin
ANA_RS07930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_RS07940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ANA_RS07960	COG2831	hemolysin activation secretion protein
ANA_RS07985	COG0513	Belongs to the DEAD box helicase family
ANA_RS08000	COG0592	DNA-directed DNA polymerase activity
ANA_RS08005	COG2010	Cytochrome c
ANA_RS08065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ANA_RS08075	COG1051	belongs to the nudix hydrolase family
ANA_RS08080	COG0628	permease
ANA_RS08095	COG1979	alcohol dehydrogenase
ANA_RS08100	COG0151	Belongs to the GarS family
ANA_RS08125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ANA_RS08175	COG1420	regulation of RNA biosynthetic process
ANA_RS08195	COG0793	Belongs to the peptidase S41A family
ANA_RS08210	COG0850	regulation of cytokinetic process
ANA_RS08215	COG2894	cell division
ANA_RS08220	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ANA_RS08225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANA_RS08255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ANA_RS08275	COG2385	sporulation resulting in formation of a cellular spore
ANA_RS08280	COG0489	protein tyrosine kinase activity
ANA_RS08300	COG1252	NADH dehydrogenase
ANA_RS08305	COG1404	Belongs to the peptidase S8 family
ANA_RS08305	COG4935	Belongs to the peptidase S8 family
ANA_RS08330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANA_RS08335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ANA_RS08340	COG4597	amino acid ABC transporter
ANA_RS08365	COG0765	amino acid transport
ANA_RS08370	COG1126	abc transporter atp-binding protein
ANA_RS08385	COG0523	cobalamin synthesis protein
ANA_RS08400	COG0517	IMP dehydrogenase activity
ANA_RS08400	COG1125	glycine betaine transport
ANA_RS08430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_RS08435	COG5002	protein histidine kinase activity
ANA_RS08445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ANA_RS08450	COG0237	dephospho-CoA kinase activity
ANA_RS08455	COG1587	Uroporphyrinogen-III synthase
ANA_RS08460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ANA_RS08465	COG0745	RESPONSE REGULATOR receiver
ANA_RS08505	COG1032	radical SAM domain protein
ANA_RS08515	COG0180	Tryptophanyl-tRNA synthetase
ANA_RS08525	COG0515	serine threonine protein kinase
ANA_RS08525	COG3266	domain, Protein
ANA_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
ANA_RS08545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANA_RS08550	COG0459	protein refolding
ANA_RS08555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ANA_RS08570	COG0124	histidyl-tRNA synthetase
ANA_RS08590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANA_RS08595	COG0573	inorganic phosphate transmembrane transporter activity
ANA_RS08600	COG0581	inorganic phosphate transmembrane transporter activity
ANA_RS08605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANA_RS08625	COG0515	serine threonine protein kinase
ANA_RS08625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_RS08645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANA_RS08655	COG0581	inorganic phosphate transmembrane transporter activity
ANA_RS08660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANA_RS08670	COG0629	single-stranded DNA binding
ANA_RS08675	COG1077	Cell shape determining protein MreB Mrl
ANA_RS08690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANA_RS08710	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ANA_RS08745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ANA_RS08745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ANA_RS08760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANA_RS08770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ANA_RS08790	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS08805	COG4178	(ABC) transporter
ANA_RS08835	COG3621	Patatin-like phospholipase
ANA_RS08860	COG0018	arginyl-trna synthetase
ANA_RS08865	COG1193	negative regulation of DNA recombination
ANA_RS08880	COG1215	transferase activity, transferring glycosyl groups
ANA_RS08885	COG0463	Glycosyl transferase, family 2
ANA_RS08890	COG1619	proteins homologs of microcin C7 resistance protein MccF
ANA_RS08895	COG0697	spore germination
ANA_RS08900	COG0314	molybdopterin synthase activity
ANA_RS08910	COG0811	peptide transport
ANA_RS08915	COG0848	biopolymer transport protein
ANA_RS08930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ANA_RS08960	COG2046	Belongs to the sulfate adenylyltransferase family
ANA_RS08965	COG3240	lipase activity
ANA_RS08980	COG4680	protein conserved in bacteria
ANA_RS09005	COG0584	glycerophosphoryl diester phosphodiesterase
ANA_RS09020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ANA_RS09045	COG2124	cytochrome p450
ANA_RS09090	COG2337	Toxic component of a toxin-antitoxin (TA) module
ANA_RS09115	COG3609	addiction module antidote protein, CC2985 family
ANA_RS09130	COG5433	transposase activity
ANA_RS09165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ANA_RS09175	COG0857	belongs to the CobB CobQ family
ANA_RS09245	COG1215	transferase activity, transferring glycosyl groups
ANA_RS09275	COG3259	Nickel-dependent hydrogenase
ANA_RS09285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS09305	COG0589	response to stress
ANA_RS09310	COG2205	protein histidine kinase activity
ANA_RS09315	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ANA_RS09320	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ANA_RS09325	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ANA_RS09330	COG2205	protein histidine kinase activity
ANA_RS09345	COG4279	zinc finger
ANA_RS09375	COG1185	polyribonucleotide nucleotidyltransferase activity
ANA_RS09380	COG0165	Argininosuccinate lyase
ANA_RS09390	COG1691	(AIR) carboxylase
ANA_RS09395	COG0668	transmembrane transport
ANA_RS09405	COG4166	transmembrane transport
ANA_RS09425	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ANA_RS09430	COG0336	Belongs to the RNA methyltransferase TrmD family
ANA_RS09440	COG4242	Belongs to the peptidase S51 family
ANA_RS09445	COG0189	ligase activity
ANA_RS09445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ANA_RS09455	COG0003	Pfam Anion-transporting ATPase
ANA_RS09460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ANA_RS09480	COG0316	Belongs to the HesB IscA family
ANA_RS09495	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ANA_RS09510	COG4251	negative regulation of phosphorylation
ANA_RS09510	COG2203	Gaf domain
ANA_RS09510	COG3706	GGDEF domain
ANA_RS09510	COG5001	Diguanylate cyclase
ANA_RS09530	COG0438	transferase activity, transferring glycosyl groups
ANA_RS09540	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANA_RS09540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANA_RS09540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANA_RS09540	COG1013	pyruvate-flavodoxin oxidoreductase activity
ANA_RS09545	COG0167	dihydroorotate dehydrogenase activity
ANA_RS09550	COG0205	6-phosphofructokinase activity
ANA_RS09570	COG0469	pyruvate kinase activity
ANA_RS09575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANA_RS09575	COG0574	Belongs to the PEP-utilizing enzyme family
ANA_RS09585	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ANA_RS09620	COG1252	NADH dehydrogenase
ANA_RS09670	COG0556	nucleotide-excision repair
ANA_RS09685	COG4636	protein conserved in cyanobacteria
ANA_RS09710	COG0419	ATPase involved in DNA repair
ANA_RS09720	COG2223	nitrite transmembrane transporter activity
ANA_RS09760	COG1968	undecaprenyl-diphosphatase activity
ANA_RS09765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ANA_RS09770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ANA_RS09780	COG2267	carboxylic ester hydrolase activity
ANA_RS09785	COG1361	Conserved repeat domain
ANA_RS09805	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ANA_RS09810	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_RS09815	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_RS09825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANA_RS09880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ANA_RS09900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANA_RS09900	COG0072	phenylalanine-tRNA ligase activity
ANA_RS09930	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ANA_RS09940	COG2319	Wd-40 repeat
ANA_RS09940	COG4249	Peptidase C14 caspase catalytic subunit p20
ANA_RS09950	COG1132	(ABC) transporter
ANA_RS09955	COG0328	RNA-DNA hybrid ribonuclease activity
ANA_RS09975	COG0343	queuine tRNA-ribosyltransferase activity
ANA_RS09985	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ANA_RS10010	COG1040	competence protein
ANA_RS10035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ANA_RS10055	COG1666	GTP binding
ANA_RS10080	COG1070	Carbohydrate kinase
ANA_RS10115	COG3266	domain, Protein
ANA_RS10115	COG0515	serine threonine protein kinase
ANA_RS10120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ANA_RS10140	COG0644	oxidoreductase
ANA_RS10170	COG0215	cysteine-tRNA ligase activity
ANA_RS10175	COG0523	cobalamin synthesis protein
ANA_RS10260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANA_RS10285	COG0495	leucyl-tRNA aminoacylation
ANA_RS10290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_RS10290	COG0515	serine threonine protein kinase
ANA_RS10325	COG0003	Pfam Anion-transporting ATPase
ANA_RS10355	COG0066	3-isopropylmalate dehydratase activity
ANA_RS10360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ANA_RS10365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ANA_RS10375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ANA_RS10390	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ANA_RS10395	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS10460	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ANA_RS10465	COG5398	heme oxygenase
ANA_RS10470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANA_RS10475	COG0450	alkyl hydroperoxide reductase
ANA_RS10495	COG1834	amidinotransferase
ANA_RS10515	COG0515	serine threonine protein kinase
ANA_RS10515	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS10535	COG1429	ligase activity, forming nitrogen-metal bonds
ANA_RS10540	COG0577	efflux transmembrane transporter activity
ANA_RS10540	COG1136	(ABC) transporter
ANA_RS10560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ANA_RS10580	COG1649	PFAM Uncharacterised BCR, COG1649
ANA_RS10585	COG0494	nUDIX hydrolase
ANA_RS10605	COG0516	GMP reductase activity
ANA_RS10605	COG0517	IMP dehydrogenase activity
ANA_RS10620	COG0149	triose-phosphate isomerase activity
ANA_RS10625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ANA_RS10630	COG0330	HflC and HflK could
ANA_RS10635	COG1596	polysaccharide export
ANA_RS10640	COG1131	(ABC) transporter
ANA_RS10645	COG0131	Imidazoleglycerol-phosphate dehydratase
ANA_RS10650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ANA_RS10655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANA_RS10660	COG4372	Transposase
ANA_RS10685	COG0826	peptidase U32
ANA_RS10710	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANA_RS10720	COG0504	CTP synthase activity
ANA_RS10730	COG1940	carbohydrate kinase activity
ANA_RS10740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ANA_RS10745	COG4968	Prepilin-type N-terminal cleavage methylation domain
ANA_RS10785	COG1196	nuclear chromosome segregation
ANA_RS10805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_RS10830	COG1487	ribonuclease activity
ANA_RS10840	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ANA_RS10870	COG1253	flavin adenine dinucleotide binding
ANA_RS10875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ANA_RS10910	COG0259	pyridoxamine-phosphate oxidase activity
ANA_RS10920	COG0628	permease
ANA_RS10935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ANA_RS10940	COG1166	arginine decarboxylase activity
ANA_RS10945	COG0105	UTP biosynthetic process
ANA_RS10950	COG0861	Integral membrane protein TerC family
ANA_RS10960	COG0745	RESPONSE REGULATOR receiver
ANA_RS10975	COG0419	ATPase involved in DNA repair
ANA_RS11015	COG0642	Histidine kinase
ANA_RS11015	COG3850	Histidine kinase
ANA_RS11040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ANA_RS11065	COG2161	toxin-antitoxin pair type II binding
ANA_RS11075	COG0750	zinc metalloprotease
ANA_RS11080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ANA_RS11085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ANA_RS11095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ANA_RS11110	COG0242	peptide deformylase activity
ANA_RS11145	COG0725	ABC transporter, periplasmic molybdate-binding protein
ANA_RS11150	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ANA_RS11180	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANA_RS11190	COG0426	domain, Protein
ANA_RS11190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ANA_RS11195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ANA_RS11195	COG0426	domain, Protein
ANA_RS11200	COG4399	Belongs to the UPF0754 family
ANA_RS11205	COG2226	methyltransferase
ANA_RS11215	COG2815	serine threonine protein kinase
ANA_RS11215	COG0515	serine threonine protein kinase
ANA_RS11235	COG0210	DNA helicase
ANA_RS11240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ANA_RS11260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ANA_RS11280	COG1672	PFAM Archaeal ATPase
ANA_RS11280	COG2319	Wd-40 repeat
ANA_RS11290	COG0572	uridine kinase
ANA_RS11295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ANA_RS11300	COG0460	homoserine dehydrogenase
ANA_RS11310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANA_RS11360	COG1836	PFAM Integral membrane protein DUF92
ANA_RS11415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ANA_RS11415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ANA_RS11435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ANA_RS11445	COG0148	phosphopyruvate hydratase activity
ANA_RS11480	COG0148	phosphopyruvate hydratase activity
ANA_RS11500	COG0346	lactoylglutathione lyase activity
ANA_RS11505	COG0542	response to heat
ANA_RS11550	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ANA_RS11575	COG5002	protein histidine kinase activity
ANA_RS11585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ANA_RS11590	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ANA_RS11625	COG0735	belongs to the Fur family
ANA_RS11630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANA_RS11635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ANA_RS11640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ANA_RS11650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ANA_RS11655	COG4804	nuclease activity
ANA_RS11660	COG0732	type I restriction modification DNA specificity domain
ANA_RS11680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS11700	COG1247	-acetyltransferase
ANA_RS11710	COG0739	heme binding
ANA_RS11715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ANA_RS11720	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ANA_RS11740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ANA_RS11745	COG0713	ATP synthesis coupled electron transport
ANA_RS11750	COG0839	Belongs to the complex I subunit 6 family
ANA_RS11755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS11760	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ANA_RS11765	COG0372	Belongs to the citrate synthase family
ANA_RS11770	COG2062	phosphohistidine phosphatase, SixA
ANA_RS11800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ANA_RS11815	COG2203	Gaf domain
ANA_RS11815	COG0840	transmembrane signaling receptor activity
ANA_RS11820	COG2198	Histidine kinase
ANA_RS11820	COG0784	Response regulator, receiver
ANA_RS11820	COG0643	Histidine kinase
ANA_RS11835	COG3639	organic phosphonate transmembrane transporter activity
ANA_RS11840	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ANA_RS11850	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS11855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ANA_RS11860	COG0509	glycine decarboxylation via glycine cleavage system
ANA_RS11880	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ANA_RS11885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ANA_RS11890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ANA_RS11920	COG1606	tRNA processing
ANA_RS11925	COG5002	protein histidine kinase activity
ANA_RS11945	COG1032	radical SAM domain protein
ANA_RS11950	COG5002	protein histidine kinase activity
ANA_RS11950	COG3850	Histidine kinase
ANA_RS11955	COG0784	Response regulator, receiver
ANA_RS11960	COG4251	negative regulation of phosphorylation
ANA_RS12010	COG0793	Belongs to the peptidase S41A family
ANA_RS12015	COG0515	serine threonine protein kinase
ANA_RS12015	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS12025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANA_RS12030	COG2326	polyphosphate kinase activity
ANA_RS12045	COG1797	cobyrinic acid a,c-diamide synthase activity
ANA_RS12050	COG1615	UPF0182 protein
ANA_RS12075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ANA_RS12100	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ANA_RS12105	COG0515	serine threonine protein kinase
ANA_RS12105	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS12110	COG3311	Transcriptional regulator
ANA_RS12115	COG1063	alcohol dehydrogenase
ANA_RS12155	COG0438	transferase activity, transferring glycosyl groups
ANA_RS12180	COG1086	Polysaccharide biosynthesis protein
ANA_RS12200	COG1134	teichoic acid transport
ANA_RS12215	COG0438	transferase activity, transferring glycosyl groups
ANA_RS12235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ANA_RS12240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ANA_RS12245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANA_RS12250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ANA_RS12255	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ANA_RS12270	COG0445	tRNA wobble uridine modification
ANA_RS12290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_RS12290	COG0515	serine threonine protein kinase
ANA_RS12300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ANA_RS12305	COG0751	glycine-tRNA ligase activity
ANA_RS12340	COG2217	Heavy metal translocating P-type atpase
ANA_RS12345	COG1090	epimerase
ANA_RS12365	COG2852	Protein conserved in bacteria
ANA_RS12375	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS12395	COG0450	alkyl hydroperoxide reductase
ANA_RS12440	COG1091	dTDP-4-dehydrorhamnose reductase activity
ANA_RS12480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANA_RS12485	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ANA_RS12490	COG0783	Belongs to the Dps family
ANA_RS12520	COG3266	domain, Protein
ANA_RS12520	COG0515	serine threonine protein kinase
ANA_RS12530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS12535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANA_RS12540	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANA_RS12545	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANA_RS12550	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ANA_RS12555	COG4451	ribulose bisphosphate carboxylase, small
ANA_RS12555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ANA_RS12570	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ANA_RS12580	COG0745	RESPONSE REGULATOR receiver
ANA_RS12605	COG0134	indole-3-glycerol-phosphate synthase activity
ANA_RS12610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANA_RS12625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ANA_RS12645	COG0758	DNA mediated transformation
ANA_RS12645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANA_RS12665	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ANA_RS12680	COG1234	tRNA 3'-trailer cleavage
ANA_RS12685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANA_RS12700	COG1104	cysteine desulfurase activity
ANA_RS12705	COG0531	amino acid
ANA_RS12720	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ANA_RS12725	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ANA_RS12735	COG1473	amidohydrolase
ANA_RS12740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ANA_RS12750	COG0515	serine threonine protein kinase
ANA_RS12750	COG4991	sh3 domain protein
ANA_RS12750	COG3064	Membrane
ANA_RS12755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ANA_RS12775	COG1217	gtp-binding protein TYPA
ANA_RS12780	COG0038	chloride channel
ANA_RS12800	COG0312	modulator of DNA gyrase
ANA_RS12810	COG1573	uracil-dna glycosylase
ANA_RS12820	COG1058	Belongs to the CinA family
ANA_RS12820	COG1546	Belongs to the CinA family
ANA_RS12835	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ANA_RS12880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANA_RS12895	COG1215	transferase activity, transferring glycosyl groups
ANA_RS12900	COG0438	transferase activity, transferring glycosyl groups
ANA_RS12935	COG1696	Membrane protein involved in D-alanine export
ANA_RS12945	COG0463	Glycosyl transferase, family 2
ANA_RS12970	COG0438	transferase activity, transferring glycosyl groups
ANA_RS12980	COG0438	transferase activity, transferring glycosyl groups
ANA_RS13000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_RS13005	COG0463	Glycosyl transferase, family 2
ANA_RS13030	COG0489	protein tyrosine kinase activity
ANA_RS13045	COG0501	Belongs to the peptidase M48B family
ANA_RS13050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ANA_RS13055	COG0321	lipoyl(octanoyl) transferase activity
ANA_RS13060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ANA_RS13065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANA_RS13110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ANA_RS13125	COG0768	penicillin binding
ANA_RS13155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ANA_RS13185	COG0191	fructose-bisphosphate aldolase activity
ANA_RS13235	COG2226	methyltransferase
ANA_RS13250	COG1045	serine acetyltransferase
ANA_RS13285	COG1372	Participates in initiation and elongation during chromosome replication
ANA_RS13285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ANA_RS13290	COG3977	Valine--pyruvate aminotransferase
ANA_RS13295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ANA_RS13310	COG2132	Multicopper oxidase
ANA_RS13325	COG0310	cobalt ion transport
ANA_RS13335	COG1122	ATPase activity
ANA_RS13345	COG0514	ATP-dependent DNA helicase (RecQ)
ANA_RS13350	COG1446	asparaginase
ANA_RS13355	COG0167	dihydroorotate dehydrogenase activity
ANA_RS13370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANA_RS13370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANA_RS13395	COG0745	RESPONSE REGULATOR receiver
ANA_RS13400	COG5002	protein histidine kinase activity
ANA_RS13405	COG0704	Plays a role in the regulation of phosphate uptake
ANA_RS13410	COG3659	wide pore channel activity
ANA_RS13415	COG0277	FAD linked oxidase domain protein
ANA_RS13420	COG0247	lactate metabolic process
ANA_RS13430	COG2442	InterPro IPR007367
ANA_RS13440	COG0515	serine threonine protein kinase
ANA_RS13440	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS13445	COG0572	uridine kinase
ANA_RS13450	COG2003	Belongs to the UPF0758 family
ANA_RS13465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANA_RS13475	COG0384	phenazine biosynthesis protein PhzF
ANA_RS13490	COG0612	Peptidase, M16
ANA_RS13495	COG0612	Peptidase, M16
ANA_RS13500	COG0004	ammonium transporteR
ANA_RS13515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ANA_RS13520	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS13535	COG1106	Psort location Cytoplasmic, score
ANA_RS13545	COG4636	protein conserved in cyanobacteria
ANA_RS13580	COG1657	PFAM Prenyltransferase squalene oxidase
ANA_RS13605	COG0612	Peptidase, M16
ANA_RS13610	COG2226	methyltransferase
ANA_RS13620	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ANA_RS13645	COG0799	negative regulation of ribosome biogenesis
ANA_RS13670	COG1494	fructose-1,6-bisphosphatase
ANA_RS13675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ANA_RS13700	COG0019	diaminopimelate decarboxylase activity
ANA_RS13715	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ANA_RS13715	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
ANA_RS13730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANA_RS13740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ANA_RS13750	COG0194	GDP metabolic process
ANA_RS13755	COG2052	Domain of unknown function (DUF370)
ANA_RS13780	COG0142	geranyltranstransferase activity
ANA_RS13790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ANA_RS13795	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANA_RS13800	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANA_RS13800	COG2247	cell wall binding repeat
ANA_RS13805	COG0475	glutathione-regulated potassium exporter activity
ANA_RS13820	COG1012	belongs to the aldehyde dehydrogenase family
ANA_RS13825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS13830	COG2059	Chromate
ANA_RS13835	COG0584	glycerophosphoryl diester phosphodiesterase
ANA_RS13840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANA_RS13845	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ANA_RS13850	COG0310	cobalt ion transport
ANA_RS13855	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
ANA_RS13865	COG1122	ATPase activity
ANA_RS13885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ANA_RS13910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_RS13920	COG0248	Ppx GppA phosphatase
ANA_RS13925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ANA_RS13935	COG2208	phosphoserine phosphatase activity
ANA_RS13950	COG0552	protein localization to endoplasmic reticulum
ANA_RS13955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANA_RS13965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ANA_RS13975	COG4221	oxidoreductase activity
ANA_RS13995	COG0589	response to stress
ANA_RS14000	COG0126	phosphoglycerate kinase activity
ANA_RS14020	COG0515	serine threonine protein kinase
ANA_RS14020	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS14045	COG4636	protein conserved in cyanobacteria
ANA_RS14070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ANA_RS14075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ANA_RS14085	COG2912	Transglutaminase-like superfamily
ANA_RS14095	COG1160	GTP binding
ANA_RS14100	COG1136	(ABC) transporter
ANA_RS14105	COG1136	(ABC) transporter
ANA_RS14105	COG0577	efflux transmembrane transporter activity
ANA_RS14110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANA_RS14140	COG0438	transferase activity, transferring glycosyl groups
ANA_RS14145	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ANA_RS14150	COG0546	phosphoglycolate phosphatase activity
ANA_RS14155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ANA_RS14160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANA_RS14165	COG0824	Thioesterase
ANA_RS14170	COG0318	PFAM AMP-dependent synthetase and ligase
ANA_RS14180	COG1575	Belongs to the MenA family. Type 1 subfamily
ANA_RS14190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ANA_RS14270	COG0003	Pfam Anion-transporting ATPase
ANA_RS14280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ANA_RS14290	COG1233	COG1233 Phytoene dehydrogenase and related
ANA_RS14300	COG3956	TIGRFAM MazG family protein
ANA_RS14315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ANA_RS14320	COG4636	protein conserved in cyanobacteria
ANA_RS14350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ANA_RS14360	COG0277	FAD linked oxidase domain protein
ANA_RS14375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_RS14385	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ANA_RS14390	COG4221	oxidoreductase activity
ANA_RS14400	COG1570	exodeoxyribonuclease VII activity
ANA_RS14430	COG0156	8-amino-7-oxononanoate synthase activity
ANA_RS14435	COG0632	four-way junction helicase activity
ANA_RS14440	COG0561	phosphatase activity
ANA_RS14445	COG0561	phosphatase activity
ANA_RS14490	COG1722	exodeoxyribonuclease VII activity
ANA_RS14525	COG0515	serine threonine protein kinase
ANA_RS14525	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS14535	COG1012	belongs to the aldehyde dehydrogenase family
ANA_RS14580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ANA_RS14585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ANA_RS14590	COG3409	Peptidoglycan-binding domain 1 protein
ANA_RS14590	COG3429	Glucose-6-phosphate dehydrogenase subunit
ANA_RS14615	COG1943	Transposase
ANA_RS14620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ANA_RS14640	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ANA_RS14650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ANA_RS14675	COG2045	Belongs to the ComB family
ANA_RS14680	COG2363	Small membrane protein
ANA_RS14690	COG0556	nucleotide-excision repair
ANA_RS14695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ANA_RS14700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ANA_RS14710	COG0582	viral genome integration into host DNA
ANA_RS14715	COG5433	transposase activity
ANA_RS14755	COG2815	serine threonine protein kinase
ANA_RS14755	COG0515	serine threonine protein kinase
ANA_RS14950	COG0582	viral genome integration into host DNA
ANA_RS14960	COG4178	(ABC) transporter
ANA_RS14965	COG1874	Beta-galactosidase
ANA_RS14965	COG0366	Alpha amylase catalytic
ANA_RS14975	COG0463	Glycosyl transferase, family 2
ANA_RS14990	COG0318	PFAM AMP-dependent synthetase and ligase
ANA_RS15015	COG1028	Short-chain dehydrogenase reductase Sdr
ANA_RS15035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANA_RS15040	COG1819	glycosyl
ANA_RS15065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ANA_RS15095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ANA_RS15100	COG0719	Fe-S assembly protein
ANA_RS15105	COG0396	ATPase activity
ANA_RS15110	COG0719	Fe-S assembly protein
ANA_RS15150	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS15170	COG0659	secondary active sulfate transmembrane transporter activity
ANA_RS15185	COG0393	Putative heavy-metal-binding
ANA_RS15205	COG2197	response regulator
ANA_RS15215	COG1053	succinate dehydrogenase
ANA_RS15220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS15230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS15255	COG0701	Predicted permease
ANA_RS15270	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANA_RS15305	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ANA_RS15310	COG0830	nickel cation binding
ANA_RS15315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ANA_RS15335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ANA_RS15345	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ANA_RS15350	COG0798	PFAM Bile acid sodium symporter
ANA_RS15360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ANA_RS15365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANA_RS15390	COG3394	polysaccharide catabolic process
ANA_RS15455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ANA_RS15460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ANA_RS15475	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ANA_RS15480	COG0489	protein tyrosine kinase activity
ANA_RS15500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ANA_RS15520	COG1132	(ABC) transporter
ANA_RS15530	COG0463	Glycosyl transferase, family 2
ANA_RS15530	COG1216	Glycosyl transferase, family 2
ANA_RS15535	COG1215	transferase activity, transferring glycosyl groups
ANA_RS15550	COG0438	transferase activity, transferring glycosyl groups
ANA_RS15555	COG0438	transferase activity, transferring glycosyl groups
ANA_RS15560	COG1216	Glycosyl transferase, family 2
ANA_RS15565	COG0438	transferase activity, transferring glycosyl groups
ANA_RS15595	COG0134	indole-3-glycerol-phosphate synthase activity
ANA_RS15600	COG1088	dTDP-glucose 4,6-dehydratase activity
ANA_RS15635	COG1845	cytochrome c oxidase, subunit III
ANA_RS15640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANA_RS15645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ANA_RS15655	COG0109	protoheme IX farnesyltransferase activity
ANA_RS15665	COG1543	Belongs to the glycosyl hydrolase 57 family
ANA_RS15670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ANA_RS15685	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANA_RS15690	COG1162	GTPase activity
ANA_RS15700	COG0484	heat shock protein binding
ANA_RS15705	COG0443	Heat shock 70 kDa protein
ANA_RS15710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ANA_RS15715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ANA_RS15725	COG1459	type II secretion system
ANA_RS15730	COG1748	Saccharopine dehydrogenase
ANA_RS15735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANA_RS15735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANA_RS15740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ANA_RS15750	COG0561	phosphatase activity
ANA_RS15760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANA_RS15765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANA_RS15770	COG0515	serine threonine protein kinase
ANA_RS15775	COG0583	DNA-binding transcription factor activity
ANA_RS15785	COG3118	belongs to the thioredoxin family
ANA_RS15790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANA_RS15805	COG4636	protein conserved in cyanobacteria
ANA_RS15830	COG0667	Aldo Keto reductase
ANA_RS15870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANA_RS15875	COG1372	Participates in initiation and elongation during chromosome replication
ANA_RS15875	COG0187	DNA topoisomerase II activity
ANA_RS15880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ANA_RS15890	COG4680	protein conserved in bacteria
ANA_RS15905	COG0706	membrane insertase activity
ANA_RS15915	COG0594	ribonuclease P activity
ANA_RS15950	COG2337	Toxic component of a toxin-antitoxin (TA) module
ANA_RS16005	COG0484	heat shock protein binding
ANA_RS16010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ANA_RS16015	COG1959	2 iron, 2 sulfur cluster binding
ANA_RS16020	COG3659	wide pore channel activity
ANA_RS16035	COG1122	ATPase activity
ANA_RS16045	COG3688	RNA-binding protein containing a PIN domain
ANA_RS16055	COG4771	TonB-dependent receptor
ANA_RS16100	COG0604	alcohol dehydrogenase
ANA_RS16100	COG3321	synthase
ANA_RS16105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ANA_RS16105	COG3321	synthase
ANA_RS16105	COG4221	oxidoreductase activity
ANA_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
ANA_RS16115	COG0300	oxidoreductase activity
ANA_RS16115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANA_RS16115	COG4221	oxidoreductase activity
ANA_RS16115	COG3321	synthase
ANA_RS16120	COG2070	2-Nitropropane dioxygenase
ANA_RS16120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANA_RS16125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANA_RS16125	COG3320	Male sterility
ANA_RS16130	COG0300	oxidoreductase activity
ANA_RS16135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANA_RS16155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANA_RS16160	COG0515	serine threonine protein kinase
ANA_RS16180	COG0521	Mo-molybdopterin cofactor biosynthetic process
ANA_RS16190	COG1785	Belongs to the alkaline phosphatase family
ANA_RS16200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ANA_RS16210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_RS16220	COG3119	arylsulfatase activity
ANA_RS16225	COG0525	valine-tRNA ligase activity
ANA_RS16255	COG2274	protein secretion by the type I secretion system
ANA_RS16280	COG1054	Belongs to the UPF0176 family
ANA_RS16285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANA_RS16285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANA_RS16310	COG1487	ribonuclease activity
ANA_RS16320	COG1555	photosystem II stabilization
ANA_RS16325	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ANA_RS16370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANA_RS16385	COG0010	Belongs to the arginase family
ANA_RS16390	COG2264	protein methyltransferase activity
ANA_RS16395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANA_RS16400	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ANA_RS16405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ANA_RS16440	COG2124	cytochrome p450
ANA_RS16450	COG0513	Belongs to the DEAD box helicase family
ANA_RS16455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANA_RS16460	COG0434	BtpA family
ANA_RS16465	COG4243	Vitamin k epoxide reductase
ANA_RS16470	COG0542	response to heat
ANA_RS16490	COG1773	rubredoxin
ANA_RS16495	COG2081	HI0933 family
ANA_RS16500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANA_RS16505	COG0848	biopolymer transport protein
ANA_RS16510	COG0811	peptide transport
ANA_RS16515	COG2226	methyltransferase
ANA_RS16520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ANA_RS16535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ANA_RS16545	COG3852	Histidine kinase
ANA_RS16560	COG0772	Belongs to the SEDS family
ANA_RS16565	COG0489	protein tyrosine kinase activity
ANA_RS16575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANA_RS16580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANA_RS16625	COG1131	(ABC) transporter
ANA_RS16650	COG0788	formyltetrahydrofolate deformylase activity
ANA_RS16665	COG0315	cyclic pyranopterin monophosphate synthase activity
ANA_RS16675	COG0477	Major facilitator Superfamily
ANA_RS16680	COG0463	Glycosyl transferase, family 2
ANA_RS16685	COG0791	NLP P60 protein
ANA_RS16730	COG4115	mRNA cleavage
ANA_RS16745	COG0515	serine threonine protein kinase
ANA_RS16745	COG3266	domain, Protein
ANA_RS16750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ANA_RS16780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ANA_RS16790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANA_RS16800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANA_RS16805	COG1104	cysteine desulfurase activity
ANA_RS16810	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ANA_RS16810	COG2906	2 iron, 2 sulfur cluster binding
ANA_RS16810	COG0822	iron-sulfur transferase activity
ANA_RS16815	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ANA_RS16975	COG1324	tolerance protein
ANA_RS17055	COG0631	protein serine/threonine phosphatase activity
ANA_RS17200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANA_RS17235	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ANA_RS17280	COG0582	viral genome integration into host DNA
ANA_RS17285	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ANA_RS17290	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_RS17295	COG2319	Wd-40 repeat
ANA_RS17295	COG3903	Transcriptional regulator
ANA_RS17335	COG3903	Transcriptional regulator
ANA_RS17335	COG2319	Wd-40 repeat
ANA_RS17385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANA_RS17390	COG1598	PFAM Uncharacterised protein family UPF0150
ANA_RS17400	COG0582	viral genome integration into host DNA
ANA_RS17405	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_RS17410	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_RS17415	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANA_RS17430	COG5420	small protein containing a coiled-coil domain
ANA_RS17440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ANA_RS17445	COG0316	Belongs to the HesB IscA family
ANA_RS17450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANA_RS17490	COG4636	protein conserved in cyanobacteria
ANA_RS17495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANA_RS17515	COG0515	serine threonine protein kinase
ANA_RS17515	COG2815	serine threonine protein kinase
ANA_RS17525	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ANA_RS17535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ANA_RS17540	COG0170	dolichyl monophosphate biosynthetic process
ANA_RS17590	COG0528	UMP kinase activity
ANA_RS17595	COG0233	cytoplasmic translational termination
ANA_RS17685	COG1702	phosphate starvation-inducible protein PhoH
ANA_RS17695	COG0228	four-way junction DNA binding
ANA_RS17755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ANA_RS17760	COG0612	Peptidase, M16
ANA_RS17780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ANA_RS17815	COG0515	serine threonine protein kinase
ANA_RS17830	COG0439	Biotin carboxylase
ANA_RS17850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ANA_RS17880	COG0515	serine threonine protein kinase
ANA_RS17880	COG3064	Membrane
ANA_RS17880	COG4991	sh3 domain protein
ANA_RS17885	COG0037	tRNA processing
ANA_RS17910	COG2198	Histidine kinase
ANA_RS17910	COG0643	Histidine kinase
ANA_RS17910	COG2198	Histidine kinase
ANA_RS17910	COG0643	Histidine kinase
ANA_RS17925	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ANA_RS17930	COG0745	RESPONSE REGULATOR receiver
ANA_RS17945	COG1007	ATP synthesis coupled electron transport
ANA_RS17985	COG2988	succinylglutamate desuccinylase activity
ANA_RS18010	COG1404	Belongs to the peptidase S8 family
ANA_RS18015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANA_RS18015	COG1754	DNA topoisomerase type I activity
ANA_RS18025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ANA_RS18035	COG1480	7TM receptor with intracellular HD hydrolase
ANA_RS18080	COG5002	protein histidine kinase activity
ANA_RS18080	COG0784	Response regulator, receiver
ANA_RS18095	COG0307	riboflavin synthase, alpha
ANA_RS18100	COG0739	heme binding
ANA_RS18100	COG0741	lytic transglycosylase activity
ANA_RS18100	COG1196	nuclear chromosome segregation
ANA_RS18105	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ANA_RS18105	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ANA_RS18110	COG1496	oxidoreductase activity
ANA_RS18140	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ANA_RS18145	COG0519	Catalyzes the synthesis of GMP from XMP
ANA_RS18145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANA_RS18150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANA_RS18155	COG0189	ligase activity
ANA_RS18160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ANA_RS18205	COG4447	cellulose binding
ANA_RS18210	COG1773	rubredoxin
ANA_RS18220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS18225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS18230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANA_RS18250	COG0251	oxidation-reduction process
ANA_RS18265	COG2816	NAD+ diphosphatase activity
ANA_RS18270	COG1640	4-alpha-glucanotransferase
ANA_RS18275	COG1426	Protein conserved in bacteria
ANA_RS18280	COG1187	pseudouridine synthase activity
ANA_RS18290	COG0575	Belongs to the CDS family
ANA_RS18300	COG0515	serine threonine protein kinase
ANA_RS18300	COG3266	domain, Protein
ANA_RS18310	COG2885	chlorophyll binding
ANA_RS18325	COG2066	Belongs to the glutaminase family
ANA_RS18335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ANA_RS18340	COG1487	ribonuclease activity
ANA_RS18360	COG0515	serine threonine protein kinase
ANA_RS18380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ANA_RS18385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ANA_RS18395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ANA_RS18410	COG0572	uridine kinase
ANA_RS18425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ANA_RS18430	COG2205	protein histidine kinase activity
ANA_RS18440	COG4251	negative regulation of phosphorylation
ANA_RS18445	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ANA_RS18485	COG0602	queuosine metabolic process
ANA_RS18490	COG0720	synthase
ANA_RS18525	COG4783	chaperone-mediated protein folding
ANA_RS18530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANA_RS18545	COG0617	tRNA 3'-terminal CCA addition
ANA_RS18555	COG1214	PFAM Peptidase M22, glycoprotease
ANA_RS18580	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANA_RS18580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANA_RS18580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANA_RS18580	COG1013	pyruvate-flavodoxin oxidoreductase activity
ANA_RS18595	COG0583	DNA-binding transcription factor activity
ANA_RS18600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ANA_RS18605	COG0243	molybdopterin cofactor binding
ANA_RS18610	COG2223	nitrite transmembrane transporter activity
ANA_RS18640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ANA_RS18645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ANA_RS18670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ANA_RS18680	COG2133	pyrroloquinoline quinone binding
ANA_RS18680	COG5183	chlorophyll binding
ANA_RS18720	COG0157	Belongs to the NadC ModD family
ANA_RS18725	COG0436	Aminotransferase
ANA_RS18730	COG3118	belongs to the thioredoxin family
ANA_RS18760	COG1842	Phage shock protein A
ANA_RS18765	COG1842	Phage shock protein A
ANA_RS18785	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ANA_RS18790	COG3266	domain, Protein
ANA_RS18790	COG0515	serine threonine protein kinase
ANA_RS18805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS18810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS18820	COG4636	protein conserved in cyanobacteria
ANA_RS18825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ANA_RS18830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ANA_RS18835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANA_RS18840	COG2048	Heterodisulfide reductase, subunit B
ANA_RS18845	COG0242	peptide deformylase activity
ANA_RS18850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS18890	COG2890	protein-(glutamine-N5) methyltransferase activity
ANA_RS19650	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ANA_RS19650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ANA_RS20075	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ANA_RS20075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ANA_RS20095	COG0081	regulation of translation
ANA_RS20650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANA_RS20935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ANA_RS21285	COG1754	DNA topoisomerase type I activity
ANA_RS21285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANA_RS21730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ANA_RS22445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ANA_RS23075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ANA_RS23285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANA_RS23350	COG0784	Response regulator, receiver
ANA_RS23380	COG1401	restriction endodeoxyribonuclease activity
ANA_RS23390	COG1216	Glycosyl transferase, family 2
ANA_RS23400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANA_RS23400	COG0515	serine threonine protein kinase
ANA_RS23405	COG2205	protein histidine kinase activity
ANA_RS23415	COG0571	ribonuclease III activity
ANA_RS23420	COG0515	serine threonine protein kinase
ANA_RS23420	COG3266	domain, Protein
ANA_RS23515	COG5001	Diguanylate cyclase
ANA_RS23515	COG4251	negative regulation of phosphorylation
ANA_RS23515	COG3706	GGDEF domain
ANA_RS23515	COG2203	Gaf domain
ANA_RS23570	COG0484	heat shock protein binding
ANA_RS23580	COG2226	methyltransferase
ANA_RS23590	COG1216	Glycosyl transferase, family 2
ANA_RS23590	COG0463	Glycosyl transferase, family 2
ANA_RS23595	COG1216	Glycosyl transferase, family 2
ANA_RS23595	COG0463	Glycosyl transferase, family 2
ANA_RS23600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS23640	COG1215	transferase activity, transferring glycosyl groups
ANA_RS23645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANA_RS23700	COG1357	PFAM Pentapeptide repeats (8 copies)
ANA_RS23700	COG0515	serine threonine protein kinase
ANA_RS23725	COG2319	Wd-40 repeat
ANA_RS23725	COG3903	Transcriptional regulator