locus-tag	class	description
AA650_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA650_RS00025	COG0515	serine threonine protein kinase
AA650_RS00035	COG1187	pseudouridine synthase activity
AA650_RS00045	COG0443	Heat shock 70 kDa protein
AA650_RS00080	COG0237	dephospho-CoA kinase activity
AA650_RS00080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA650_RS00095	COG0489	protein tyrosine kinase activity
AA650_RS00100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA650_RS00120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA650_RS00145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA650_RS00165	COG0367	asparagine synthase
AA650_RS00200	COG0440	acetolactate synthase activity
AA650_RS00215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AA650_RS00265	COG2022	thiamine diphosphate biosynthetic process
AA650_RS00265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA650_RS00275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA650_RS00315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA650_RS00330	COG0402	S-adenosylhomocysteine deaminase activity
AA650_RS00360	COG0598	Magnesium transport protein CorA
AA650_RS00365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA650_RS00375	COG1132	(ABC) transporter
AA650_RS00380	COG0328	RNA-DNA hybrid ribonuclease activity
AA650_RS00395	COG3385	transposase activity
AA650_RS00415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA650_RS00420	COG1252	NADH dehydrogenase
AA650_RS00465	COG4251	negative regulation of phosphorylation
AA650_RS00470	COG0784	Response regulator, receiver
AA650_RS00480	COG1032	radical SAM domain protein
AA650_RS00490	COG1505	serine-type exopeptidase activity
AA650_RS00500	COG1051	belongs to the nudix hydrolase family
AA650_RS00505	COG0628	permease
AA650_RS00510	COG1979	alcohol dehydrogenase
AA650_RS00525	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AA650_RS00530	COG5322	oxidoreductase activity
AA650_RS00535	COG0825	malonyl-CoA metabolic process
AA650_RS00540	COG0300	oxidoreductase activity
AA650_RS00545	COG0302	gtp cyclohydrolase
AA650_RS00550	COG0135	phosphoribosylanthranilate isomerase activity
AA650_RS00560	COG1994	Peptidase M50
AA650_RS00560	COG0517	IMP dehydrogenase activity
AA650_RS00570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA650_RS00575	COG5398	heme oxygenase
AA650_RS00580	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AA650_RS00590	COG1121	(ABC) transporter
AA650_RS00595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA650_RS00620	COG1160	GTP binding
AA650_RS00625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA650_RS00665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AA650_RS00685	COG1752	Esterase of the alpha-beta hydrolase superfamily
AA650_RS00690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA650_RS00720	COG0411	ABC transporter
AA650_RS00730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA650_RS00730	COG0072	phenylalanine-tRNA ligase activity
AA650_RS00750	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AA650_RS00770	COG0515	serine threonine protein kinase
AA650_RS00780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS00825	COG1372	Participates in initiation and elongation during chromosome replication
AA650_RS00825	COG0305	Participates in initiation and elongation during chromosome replication
AA650_RS00830	COG0359	binds to the 23S rRNA
AA650_RS00850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA650_RS00860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA650_RS00875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AA650_RS00895	COG3631	Ketosteroid isomerase-related protein
AA650_RS00900	COG0515	serine threonine protein kinase
AA650_RS00920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA650_RS00925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA650_RS00935	COG0175	sulfate reduction
AA650_RS00960	COG0784	Response regulator, receiver
AA650_RS00960	COG5002	protein histidine kinase activity
AA650_RS00960	COG2205	protein histidine kinase activity
AA650_RS00990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AA650_RS01000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS01025	COG1285	pathogenesis
AA650_RS01030	COG0574	Belongs to the PEP-utilizing enzyme family
AA650_RS01030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA650_RS01040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA650_RS01055	COG0163	prenyltransferase activity
AA650_RS01060	COG0557	exoribonuclease II activity
AA650_RS01070	COG0740	serine-type endopeptidase activity
AA650_RS01075	COG0672	)-iron permease
AA650_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_RS01100	COG1082	Xylose isomerase domain protein TIM barrel
AA650_RS01105	COG2814	Major facilitator Superfamily
AA650_RS01110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA650_RS01115	COG2132	Multicopper oxidase
AA650_RS01160	COG0310	cobalt ion transport
AA650_RS01170	COG1122	ATPase activity
AA650_RS01185	COG0514	ATP-dependent DNA helicase (RecQ)
AA650_RS01190	COG1446	asparaginase
AA650_RS01200	COG0167	dihydroorotate dehydrogenase activity
AA650_RS01215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA650_RS01215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA650_RS01240	COG0745	RESPONSE REGULATOR receiver
AA650_RS01245	COG5002	protein histidine kinase activity
AA650_RS01250	COG0704	Plays a role in the regulation of phosphate uptake
AA650_RS01255	COG3659	wide pore channel activity
AA650_RS01260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AA650_RS01285	COG1214	PFAM Peptidase M22, glycoprotease
AA650_RS01295	COG0617	tRNA 3'-terminal CCA addition
AA650_RS01310	COG4783	chaperone-mediated protein folding
AA650_RS01350	COG0666	response to abiotic stimulus
AA650_RS01355	COG0720	synthase
AA650_RS01360	COG0602	queuosine metabolic process
AA650_RS01370	COG0215	cysteine-tRNA ligase activity
AA650_RS01380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA650_RS01385	COG0406	alpha-ribazole phosphatase activity
AA650_RS01390	COG0768	penicillin binding
AA650_RS01395	COG3842	ATPase activity
AA650_RS01400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AA650_RS01405	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA650_RS01410	COG3266	domain, Protein
AA650_RS01410	COG0515	serine threonine protein kinase
AA650_RS01460	COG0515	serine threonine protein kinase
AA650_RS01460	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS01475	COG1012	belongs to the aldehyde dehydrogenase family
AA650_RS01495	COG1597	lipid kinase activity
AA650_RS01505	COG0443	Heat shock 70 kDa protein
AA650_RS01520	COG0316	Belongs to the HesB IscA family
AA650_RS01535	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA650_RS01550	COG0438	transferase activity, transferring glycosyl groups
AA650_RS01560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA650_RS01560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AA650_RS01560	COG0674	pyruvate-flavodoxin oxidoreductase activity
AA650_RS01560	COG1013	pyruvate-flavodoxin oxidoreductase activity
AA650_RS01565	COG0167	dihydroorotate dehydrogenase activity
AA650_RS01570	COG0205	6-phosphofructokinase activity
AA650_RS01615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA650_RS01620	COG1136	(ABC) transporter
AA650_RS01620	COG0577	efflux transmembrane transporter activity
AA650_RS01675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA650_RS01685	COG0483	inositol monophosphate 1-phosphatase activity
AA650_RS01695	COG3659	wide pore channel activity
AA650_RS01700	COG1959	2 iron, 2 sulfur cluster binding
AA650_RS01705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA650_RS01715	COG0484	heat shock protein binding
AA650_RS01740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AA650_RS01750	COG0557	exoribonuclease II activity
AA650_RS01795	COG0242	peptide deformylase activity
AA650_RS01815	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AA650_RS01815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA650_RS01820	COG0314	molybdopterin synthase activity
AA650_RS01825	COG0697	spore germination
AA650_RS01830	COG1619	proteins homologs of microcin C7 resistance protein MccF
AA650_RS01840	COG1819	glycosyl
AA650_RS01845	COG1215	transferase activity, transferring glycosyl groups
AA650_RS01850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA650_RS01855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA650_RS01865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA650_RS01875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA650_RS01890	COG0443	Heat shock 70 kDa protein
AA650_RS01895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA650_RS01900	COG3977	Valine--pyruvate aminotransferase
AA650_RS01905	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA650_RS01915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA650_RS01920	COG4956	integral membrane protein (PIN domain superfamily)
AA650_RS01950	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AA650_RS01965	COG2211	Major facilitator Superfamily
AA650_RS01970	COG0018	arginyl-trna synthetase
AA650_RS01980	COG2361	Protein of unknown function DUF86
AA650_RS02005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA650_RS02040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA650_RS02045	COG1294	oxidase, subunit
AA650_RS02050	COG1271	oxidase subunit
AA650_RS02090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA650_RS02095	COG1120	ATPase activity
AA650_RS02110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA650_RS02120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA650_RS02125	COG0552	protein localization to endoplasmic reticulum
AA650_RS02170	COG3321	synthase
AA650_RS02170	COG0604	alcohol dehydrogenase
AA650_RS02175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA650_RS02175	COG4221	oxidoreductase activity
AA650_RS02175	COG3321	synthase
AA650_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_RS02185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_RS02185	COG3321	synthase
AA650_RS02185	COG4221	oxidoreductase activity
AA650_RS02185	COG0300	oxidoreductase activity
AA650_RS02190	COG2070	2-Nitropropane dioxygenase
AA650_RS02190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA650_RS02195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_RS02195	COG3320	Male sterility
AA650_RS02200	COG0300	oxidoreductase activity
AA650_RS02210	COG0644	oxidoreductase
AA650_RS02225	COG3385	transposase activity
AA650_RS02250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA650_RS02255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA650_RS02265	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
AA650_RS02295	COG0484	heat shock protein binding
AA650_RS02300	COG0443	Heat shock 70 kDa protein
AA650_RS02305	COG2234	aminopeptidase activity
AA650_RS02325	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS02335	COG3118	belongs to the thioredoxin family
AA650_RS02340	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA650_RS02360	COG1022	Amp-dependent synthetase and ligase
AA650_RS02370	COG0514	ATP-dependent DNA helicase (RecQ)
AA650_RS02420	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA650_RS02440	COG0791	NLP P60 protein
AA650_RS02450	COG0463	Glycosyl transferase, family 2
AA650_RS02485	COG0315	cyclic pyranopterin monophosphate synthase activity
AA650_RS02495	COG3153	acetyltransferase
AA650_RS02500	COG0788	formyltetrahydrofolate deformylase activity
AA650_RS02510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA650_RS02525	COG1131	(ABC) transporter
AA650_RS02535	COG0006	proline dipeptidase activity
AA650_RS02545	COG0052	Belongs to the universal ribosomal protein uS2 family
AA650_RS02550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA650_RS02560	COG0515	serine threonine protein kinase
AA650_RS02560	COG3266	domain, Protein
AA650_RS02585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA650_RS02600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AA650_RS02615	COG2267	carboxylic ester hydrolase activity
AA650_RS02635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AA650_RS02650	COG5002	protein histidine kinase activity
AA650_RS02660	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AA650_RS02665	COG2201	protein-glutamate methylesterase activity
AA650_RS02685	COG0515	serine threonine protein kinase
AA650_RS02685	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS02690	COG4636	protein conserved in cyanobacteria
AA650_RS02695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA650_RS02700	COG0335	large ribosomal subunit rRNA binding
AA650_RS02710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AA650_RS02715	COG0250	Participates in transcription elongation, termination and antitermination
AA650_RS02720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AA650_RS02725	COG0081	regulation of translation
AA650_RS02730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA650_RS02735	COG0222	ribosome binding
AA650_RS02740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA650_RS02740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA650_RS02760	COG0540	Belongs to the ATCase OTCase family
AA650_RS02765	COG2239	Acts as a magnesium transporter
AA650_RS02770	COG0728	peptidoglycan biosynthetic process
AA650_RS02775	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS02780	COG1316	TRANSCRIPTIONal
AA650_RS02800	COG0539	negative regulation of cytoplasmic translation
AA650_RS02805	COG0412	Dienelactone hydrolase
AA650_RS02810	COG2188	Transcriptional regulator
AA650_RS02855	COG4969	Belongs to the N-Me-Phe pilin family
AA650_RS02875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA650_RS02885	COG0460	homoserine dehydrogenase
AA650_RS02890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA650_RS02895	COG0572	uridine kinase
AA650_RS02920	COG2319	Wd-40 repeat
AA650_RS02920	COG1672	PFAM Archaeal ATPase
AA650_RS02925	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS02935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA650_RS02960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AA650_RS03005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA650_RS03030	COG3118	belongs to the thioredoxin family
AA650_RS03035	COG0516	GMP reductase activity
AA650_RS03055	COG5635	Nacht domain
AA650_RS03055	COG2319	Wd-40 repeat
AA650_RS03065	COG0628	permease
AA650_RS03070	COG0492	ferredoxin-NADP+ reductase activity
AA650_RS03075	COG0233	cytoplasmic translational termination
AA650_RS03080	COG0528	UMP kinase activity
AA650_RS03120	COG0170	dolichyl monophosphate biosynthetic process
AA650_RS03125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA650_RS03140	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AA650_RS03150	COG0515	serine threonine protein kinase
AA650_RS03150	COG2815	serine threonine protein kinase
AA650_RS03155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA650_RS03160	COG0745	RESPONSE REGULATOR receiver
AA650_RS03170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA650_RS03180	COG2814	Major facilitator Superfamily
AA650_RS03195	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA650_RS03200	COG0271	Belongs to the BolA IbaG family
AA650_RS03210	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS03220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA650_RS03235	COG2166	iron-sulfur cluster assembly
AA650_RS03260	COG4232	protein-disulfide reductase activity
AA650_RS03265	COG1333	cytochrome c biogenesis protein
AA650_RS03270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA650_RS03275	COG0745	RESPONSE REGULATOR receiver
AA650_RS03280	COG0432	Pfam Uncharacterised protein family UPF0047
AA650_RS03290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA650_RS03295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA650_RS03305	COG0601	transmembrane transport
AA650_RS03325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA650_RS03330	COG3657	addiction module killer protein
AA650_RS03360	COG3903	Transcriptional regulator
AA650_RS03360	COG2319	Wd-40 repeat
AA650_RS03380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA650_RS03385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_RS03405	COG0811	peptide transport
AA650_RS03410	COG0848	biopolymer transport protein
AA650_RS03415	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA650_RS03425	COG2081	HI0933 family
AA650_RS03455	COG4636	protein conserved in cyanobacteria
AA650_RS03460	COG0542	response to heat
AA650_RS03480	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA650_RS03490	COG3794	PFAM blue (type 1) copper domain protein
AA650_RS03495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA650_RS03500	COG0066	3-isopropylmalate dehydratase activity
AA650_RS03515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA650_RS03535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AA650_RS03545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AA650_RS03550	COG1799	cell septum assembly
AA650_RS03555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AA650_RS03605	COG1518	maintenance of DNA repeat elements
AA650_RS03605	COG1468	defense response to virus
AA650_RS03620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_RS03620	COG3320	Male sterility
AA650_RS03630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA650_RS03630	COG2070	2-Nitropropane dioxygenase
AA650_RS03635	COG3321	synthase
AA650_RS03640	COG0604	alcohol dehydrogenase
AA650_RS03640	COG3321	synthase
AA650_RS03660	COG1136	(ABC) transporter
AA650_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_RS03670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA650_RS03685	COG0616	signal peptide processing
AA650_RS03690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA650_RS03715	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA650_RS03720	COG2226	methyltransferase
AA650_RS03725	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA650_RS03735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AA650_RS03750	COG0772	Belongs to the SEDS family
AA650_RS03755	COG0489	protein tyrosine kinase activity
AA650_RS03770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_RS03785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA650_RS03785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA650_RS03805	COG3385	transposase activity
AA650_RS03815	COG0484	heat shock protein binding
AA650_RS03820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA650_RS03825	COG1045	serine acetyltransferase
AA650_RS03840	COG1420	regulation of RNA biosynthetic process
AA650_RS03860	COG0483	inositol monophosphate 1-phosphatase activity
AA650_RS03880	COG0363	glucosamine-6-phosphate deaminase activity
AA650_RS03885	COG1716	ATPase activity
AA650_RS03890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA650_RS03920	COG1222	aaa ATPase
AA650_RS03925	COG1049	propionate catabolic process, 2-methylcitrate cycle
AA650_RS03985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA650_RS04015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA650_RS04070	COG1472	Belongs to the glycosyl hydrolase 3 family
AA650_RS04075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA650_RS04080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA650_RS04080	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AA650_RS04085	COG1562	ergosterol biosynthetic process
AA650_RS04100	COG0071	Belongs to the small heat shock protein (HSP20) family
AA650_RS04150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AA650_RS04180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA650_RS04220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA650_RS04225	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AA650_RS04235	COG0321	lipoyl(octanoyl) transferase activity
AA650_RS04240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA650_RS04245	COG0501	Belongs to the peptidase M48B family
AA650_RS04255	COG0489	protein tyrosine kinase activity
AA650_RS04265	COG0110	maltose O-acetyltransferase activity
AA650_RS04275	COG0463	Glycosyl transferase, family 2
AA650_RS04280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_RS04305	COG0438	transferase activity, transferring glycosyl groups
AA650_RS04340	COG2089	acid synthase
AA650_RS04365	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AA650_RS04375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA650_RS04380	COG1132	(ABC) transporter
AA650_RS04385	COG1086	Polysaccharide biosynthesis protein
AA650_RS04415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_RS04425	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AA650_RS04445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS04455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA650_RS04465	COG0038	chloride channel
AA650_RS04480	COG0312	modulator of DNA gyrase
AA650_RS04490	COG1573	uracil-dna glycosylase
AA650_RS04505	COG1546	Belongs to the CinA family
AA650_RS04505	COG1058	Belongs to the CinA family
AA650_RS04515	COG1032	radical SAM domain protein
AA650_RS04530	COG0180	Tryptophanyl-tRNA synthetase
AA650_RS04570	COG0124	histidyl-tRNA synthetase
AA650_RS04595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA650_RS04600	COG0573	inorganic phosphate transmembrane transporter activity
AA650_RS04605	COG0581	inorganic phosphate transmembrane transporter activity
AA650_RS04610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA650_RS04660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AA650_RS04670	COG4636	protein conserved in cyanobacteria
AA650_RS04685	COG0724	RNA recognition motif
AA650_RS04705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS04725	COG0083	homoserine kinase activity
AA650_RS04735	COG0515	serine threonine protein kinase
AA650_RS04735	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS04740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AA650_RS04745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA650_RS04755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AA650_RS04760	COG0512	Glutamine amidotransferase of anthranilate synthase
AA650_RS04765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA650_RS04775	COG0004	ammonium transporteR
AA650_RS04785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA650_RS04795	COG1748	Saccharopine dehydrogenase
AA650_RS04800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA650_RS04810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA650_RS04815	COG0415	Belongs to the DNA photolyase family
AA650_RS04820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA650_RS04825	COG3383	formate dehydrogenase (NAD+) activity
AA650_RS04835	COG2223	nitrite transmembrane transporter activity
AA650_RS04895	COG3385	transposase activity
AA650_RS04980	COG0739	heme binding
AA650_RS04985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AA650_RS04990	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AA650_RS04995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA650_RS05000	COG0713	ATP synthesis coupled electron transport
AA650_RS05005	COG0839	Belongs to the complex I subunit 6 family
AA650_RS05010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS05015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA650_RS05020	COG0372	Belongs to the citrate synthase family
AA650_RS05025	COG2062	phosphohistidine phosphatase, SixA
AA650_RS05040	COG1131	(ABC) transporter
AA650_RS05050	COG2203	Gaf domain
AA650_RS05050	COG0840	transmembrane signaling receptor activity
AA650_RS05055	COG2198	Histidine kinase
AA650_RS05055	COG0784	Response regulator, receiver
AA650_RS05055	COG0643	Histidine kinase
AA650_RS05065	COG0596	Alpha beta hydrolase
AA650_RS05070	COG3639	organic phosphonate transmembrane transporter activity
AA650_RS05080	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AA650_RS05100	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS05105	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA650_RS05110	COG0509	glycine decarboxylation via glycine cleavage system
AA650_RS05120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA650_RS05125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA650_RS05160	COG4279	zinc finger
AA650_RS05175	COG0393	Putative heavy-metal-binding
AA650_RS05190	COG0659	secondary active sulfate transmembrane transporter activity
AA650_RS05210	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS05260	COG0719	Fe-S assembly protein
AA650_RS05265	COG0396	ATPase activity
AA650_RS05270	COG0719	Fe-S assembly protein
AA650_RS05275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA650_RS05280	COG0454	-acetyltransferase
AA650_RS05285	COG5002	protein histidine kinase activity
AA650_RS05375	COG0814	amino acid
AA650_RS05410	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
AA650_RS05435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AA650_RS05465	COG3429	Glucose-6-phosphate dehydrogenase subunit
AA650_RS05465	COG3409	Peptidoglycan-binding domain 1 protein
AA650_RS05470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA650_RS05475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AA650_RS05485	COG0745	RESPONSE REGULATOR receiver
AA650_RS05495	COG0784	Response regulator, receiver
AA650_RS05495	COG5002	protein histidine kinase activity
AA650_RS05515	COG0395	ABC-type sugar transport system, permease component
AA650_RS05535	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AA650_RS05550	COG0515	serine threonine protein kinase
AA650_RS05565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA650_RS05575	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS05580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_RS05585	COG1492	cobalamin metabolic process
AA650_RS05595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA650_RS05610	COG1253	flavin adenine dinucleotide binding
AA650_RS05625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AA650_RS05630	COG3237	CsbD-like
AA650_RS05645	COG3237	CsbD-like
AA650_RS05650	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AA650_RS05660	COG1132	(ABC) transporter
AA650_RS05675	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA650_RS05680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA650_RS05715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA650_RS05745	COG1193	negative regulation of DNA recombination
AA650_RS05780	COG0668	transmembrane transport
AA650_RS05785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AA650_RS05805	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AA650_RS05815	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AA650_RS05825	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA650_RS05840	COG0426	domain, Protein
AA650_RS05840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA650_RS05845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA650_RS05845	COG0426	domain, Protein
AA650_RS05850	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AA650_RS05890	COG0312	modulator of DNA gyrase
AA650_RS05905	COG0047	phosphoribosylformylglycinamidine synthase activity
AA650_RS05915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA650_RS05920	COG0735	belongs to the Fur family
AA650_RS05925	COG0330	HflC and HflK could
AA650_RS05950	COG2091	lysine biosynthetic process via aminoadipic acid
AA650_RS05955	COG0429	hydrolase of the alpha beta-hydrolase fold
AA650_RS05960	COG0745	RESPONSE REGULATOR receiver
AA650_RS05965	COG1160	GTP binding
AA650_RS05970	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AA650_RS05980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA650_RS06045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_RS06050	COG4636	protein conserved in cyanobacteria
AA650_RS06065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS06105	COG0667	Aldo Keto reductase
AA650_RS06125	COG3385	transposase activity
AA650_RS06130	COG3385	transposase activity
AA650_RS06150	COG1473	amidohydrolase
AA650_RS06165	COG1872	DUF167
AA650_RS06170	COG0473	3-isopropylmalate dehydrogenase activity
AA650_RS06180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AA650_RS06185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA650_RS06205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA650_RS06215	COG0038	chloride channel
AA650_RS06220	COG1136	(ABC) transporter
AA650_RS06235	COG2010	Cytochrome c
AA650_RS06240	COG0592	DNA-directed DNA polymerase activity
AA650_RS06250	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA650_RS06265	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA650_RS06270	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AA650_RS06280	COG0515	serine threonine protein kinase
AA650_RS06310	COG2198	Histidine kinase
AA650_RS06310	COG2205	protein histidine kinase activity
AA650_RS06310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA650_RS06310	COG0784	Response regulator, receiver
AA650_RS06320	COG0542	response to heat
AA650_RS06335	COG1127	ABC transporter
AA650_RS06340	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AA650_RS06345	COG0686	Belongs to the AlaDH PNT family
AA650_RS06355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA650_RS06375	COG1361	Conserved repeat domain
AA650_RS06385	COG3266	domain, Protein
AA650_RS06385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA650_RS06395	COG0195	Participates in both transcription termination and antitermination
AA650_RS06400	COG0779	Required for maturation of 30S ribosomal subunits
AA650_RS06405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AA650_RS06440	COG1672	PFAM Archaeal ATPase
AA650_RS06440	COG2319	Wd-40 repeat
AA650_RS06465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA650_RS06470	COG0051	transcription antitermination factor activity, RNA binding
AA650_RS06475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA650_RS06480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA650_RS06485	COG0049	tRNA binding
AA650_RS06490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AA650_RS06500	COG0316	Belongs to the HesB IscA family
AA650_RS06515	COG0070	glutamate synthase
AA650_RS06515	COG0067	glutamate synthase
AA650_RS06515	COG0069	glutamate synthase activity
AA650_RS06545	COG2076	Multidrug Resistance protein
AA650_RS06550	COG0463	Glycosyl transferase, family 2
AA650_RS06560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA650_RS06575	COG0586	Pfam SNARE associated Golgi protein
AA650_RS06580	COG1132	(ABC) transporter
AA650_RS06640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AA650_RS06645	COG0254	rRNA binding
AA650_RS06650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AA650_RS06655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA650_RS06660	COG0101	tRNA pseudouridine synthase activity
AA650_RS06665	COG0203	ribosomal protein L17
AA650_RS06670	COG0202	RNA polymerase activity
AA650_RS06675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA650_RS06680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA650_RS06690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA650_RS06695	COG0563	adenylate kinase activity
AA650_RS06700	COG0201	protein transport
AA650_RS06705	COG0200	Binds to the 23S rRNA
AA650_RS06710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AA650_RS06715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AA650_RS06720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA650_RS06725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA650_RS06730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AA650_RS06735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA650_RS06740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA650_RS06745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AA650_RS06750	COG0255	Belongs to the universal ribosomal protein uL29 family
AA650_RS06755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA650_RS06760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA650_RS06765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AA650_RS06770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA650_RS06775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA650_RS06780	COG0089	rRNA binding
AA650_RS06785	COG0088	Forms part of the polypeptide exit tunnel
AA650_RS06790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AA650_RS06830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA650_RS06845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA650_RS06855	COG0517	IMP dehydrogenase activity
AA650_RS06855	COG0617	tRNA 3'-terminal CCA addition
AA650_RS06855	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AA650_RS06860	COG4636	protein conserved in cyanobacteria
AA650_RS06885	COG3937	granule-associated protein
AA650_RS06895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA650_RS06900	COG0631	protein serine/threonine phosphatase activity
AA650_RS06910	COG0515	serine threonine protein kinase
AA650_RS06910	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS06935	COG1834	amidinotransferase
AA650_RS06960	COG0450	alkyl hydroperoxide reductase
AA650_RS06965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA650_RS06970	COG5398	heme oxygenase
AA650_RS06980	COG1230	cation diffusion facilitator family transporter
AA650_RS06985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA650_RS07020	COG2205	protein histidine kinase activity
AA650_RS07030	COG1230	cation diffusion facilitator family transporter
AA650_RS07055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA650_RS07060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA650_RS07090	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AA650_RS07100	COG0463	Glycosyl transferase, family 2
AA650_RS07135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA650_RS07150	COG0009	L-threonylcarbamoyladenylate synthase
AA650_RS07155	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AA650_RS07165	COG0312	modulator of DNA gyrase
AA650_RS07170	COG0312	modulator of DNA gyrase
AA650_RS07175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS07190	COG2183	response to ionizing radiation
AA650_RS07210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AA650_RS07225	COG1950	PFAM Membrane protein of
AA650_RS07245	COG2010	Cytochrome c
AA650_RS07270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA650_RS07275	COG0784	Response regulator, receiver
AA650_RS07280	COG0564	pseudouridine synthase activity
AA650_RS07295	COG0237	dephospho-CoA kinase activity
AA650_RS07300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AA650_RS07305	COG1413	lyase activity
AA650_RS07310	COG1413	lyase activity
AA650_RS07315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA650_RS07320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA650_RS07325	COG0237	dephospho-CoA kinase activity
AA650_RS07330	COG0237	dephospho-CoA kinase activity
AA650_RS07345	COG0121	glutamine amidotransferase
AA650_RS07350	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA650_RS07355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA650_RS07360	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AA650_RS07365	COG4208	sulfate ABC transporter
AA650_RS07375	COG1715	Restriction endonuclease
AA650_RS07385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA650_RS07395	COG2337	Toxic component of a toxin-antitoxin (TA) module
AA650_RS07405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AA650_RS07420	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AA650_RS07430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_RS07430	COG0515	serine threonine protein kinase
AA650_RS07440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AA650_RS07445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_RS07450	COG0456	acetyltransferase
AA650_RS07455	COG2010	Cytochrome c
AA650_RS07475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA650_RS07480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AA650_RS07485	COG0416	fatty acid biosynthetic process
AA650_RS07490	COG0534	Mate efflux family protein
AA650_RS07495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA650_RS07500	COG0824	Thioesterase
AA650_RS07555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA650_RS07585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AA650_RS07590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA650_RS07600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AA650_RS07605	COG1002	Type II restriction enzyme, methylase subunits
AA650_RS07615	COG0629	single-stranded DNA binding
AA650_RS07620	COG1077	Cell shape determining protein MreB Mrl
AA650_RS07635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA650_RS07645	COG0475	glutathione-regulated potassium exporter activity
AA650_RS07650	COG2247	cell wall binding repeat
AA650_RS07650	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA650_RS07655	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA650_RS07660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA650_RS07670	COG0142	geranyltranstransferase activity
AA650_RS07695	COG2052	Domain of unknown function (DUF370)
AA650_RS07700	COG0194	GDP metabolic process
AA650_RS07715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA650_RS07720	COG2267	carboxylic ester hydrolase activity
AA650_RS07735	COG0454	-acetyltransferase
AA650_RS07745	COG0824	Thioesterase
AA650_RS07750	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_RS07760	COG1575	Belongs to the MenA family. Type 1 subfamily
AA650_RS07770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA650_RS07860	COG0003	Pfam Anion-transporting ATPase
AA650_RS07865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_RS07870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA650_RS07890	COG1233	COG1233 Phytoene dehydrogenase and related
AA650_RS07900	COG3956	TIGRFAM MazG family protein
AA650_RS07915	COG4636	protein conserved in cyanobacteria
AA650_RS07945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AA650_RS07955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AA650_RS07960	COG0546	phosphoglycolate phosphatase activity
AA650_RS07965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AA650_RS07980	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA650_RS07990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA650_RS07995	COG2226	methyltransferase
AA650_RS08000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA650_RS08005	COG0569	domain protein
AA650_RS08015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AA650_RS08025	COG0792	nuclease activity
AA650_RS08045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA650_RS08050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA650_RS08065	COG3118	belongs to the thioredoxin family
AA650_RS08095	COG1487	ribonuclease activity
AA650_RS08120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA650_RS08155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA650_RS08160	COG0751	glycine-tRNA ligase activity
AA650_RS08170	COG4968	Prepilin-type N-terminal cleavage methylation domain
AA650_RS08200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA650_RS08205	COG0673	inositol 2-dehydrogenase activity
AA650_RS08215	COG0110	maltose O-acetyltransferase activity
AA650_RS08220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_RS08225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA650_RS08275	COG2886	Uncharacterised protein family (UPF0175)
AA650_RS08310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS08320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS08350	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AA650_RS08380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AA650_RS08415	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS08420	COG3609	addiction module antidote protein, CC2985 family
AA650_RS08445	COG2337	Toxic component of a toxin-antitoxin (TA) module
AA650_RS08480	COG2124	cytochrome p450
AA650_RS08505	COG0149	triose-phosphate isomerase activity
AA650_RS08510	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AA650_RS08515	COG0330	HflC and HflK could
AA650_RS08520	COG1596	polysaccharide export
AA650_RS08530	COG1131	(ABC) transporter
AA650_RS08535	COG0131	Imidazoleglycerol-phosphate dehydratase
AA650_RS08545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AA650_RS08550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_RS08555	COG4372	Transposase
AA650_RS08595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_RS08600	COG0187	DNA topoisomerase II activity
AA650_RS08600	COG1372	Participates in initiation and elongation during chromosome replication
AA650_RS08605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA650_RS08610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA650_RS08635	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA650_RS08650	COG0284	orotidine-5'-phosphate decarboxylase activity
AA650_RS08660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AA650_RS08685	COG0681	Belongs to the peptidase S26 family
AA650_RS08695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA650_RS08700	COG1652	LysM domain
AA650_RS08715	COG2310	stress, protein
AA650_RS08730	COG0539	negative regulation of cytoplasmic translation
AA650_RS08740	COG0778	Nitroreductase
AA650_RS08770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA650_RS08775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA650_RS08780	COG1845	cytochrome c oxidase, subunit III
AA650_RS08785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AA650_RS08800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA650_RS08805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA650_RS08820	COG0438	transferase activity, transferring glycosyl groups
AA650_RS08860	COG1215	transferase activity, transferring glycosyl groups
AA650_RS08875	COG1132	(ABC) transporter
AA650_RS08900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_RS08920	COG0673	inositol 2-dehydrogenase activity
AA650_RS08930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA650_RS08935	COG0489	protein tyrosine kinase activity
AA650_RS08940	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AA650_RS08985	COG1487	ribonuclease activity
AA650_RS09020	COG3385	transposase activity
AA650_RS09035	COG2337	Toxic component of a toxin-antitoxin (TA) module
AA650_RS09100	COG0594	ribonuclease P activity
AA650_RS09110	COG0706	membrane insertase activity
AA650_RS09125	COG4680	protein conserved in bacteria
AA650_RS09135	COG1185	polyribonucleotide nucleotidyltransferase activity
AA650_RS09140	COG0165	Argininosuccinate lyase
AA650_RS09150	COG1691	(AIR) carboxylase
AA650_RS09155	COG4166	transmembrane transport
AA650_RS09170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AA650_RS09175	COG0336	Belongs to the RNA methyltransferase TrmD family
AA650_RS09185	COG4242	Belongs to the peptidase S51 family
AA650_RS09190	COG0189	ligase activity
AA650_RS09190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA650_RS09195	COG1487	ribonuclease activity
AA650_RS09225	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AA650_RS09245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AA650_RS09250	COG1253	flavin adenine dinucleotide binding
AA650_RS09255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AA650_RS09290	COG0259	pyridoxamine-phosphate oxidase activity
AA650_RS09295	COG0628	permease
AA650_RS09305	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA650_RS09310	COG1166	arginine decarboxylase activity
AA650_RS09315	COG0105	UTP biosynthetic process
AA650_RS09320	COG0861	Integral membrane protein TerC family
AA650_RS09330	COG0745	RESPONSE REGULATOR receiver
AA650_RS09345	COG0419	ATPase involved in DNA repair
AA650_RS09375	COG0445	tRNA wobble uridine modification
AA650_RS09390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA650_RS09395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA650_RS09425	COG0673	inositol 2-dehydrogenase activity
AA650_RS09430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AA650_RS09445	COG2226	methyltransferase
AA650_RS09450	COG0306	phosphate transporter
AA650_RS09455	COG0697	spore germination
AA650_RS09470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA650_RS09475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AA650_RS09485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA650_RS09485	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA650_RS09545	COG0129	dihydroxy-acid dehydratase activity
AA650_RS09555	COG2319	Wd-40 repeat
AA650_RS09555	COG4249	Peptidase C14 caspase catalytic subunit p20
AA650_RS09570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA650_RS09570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA650_RS09585	COG1073	alpha beta
AA650_RS09585	COG2226	methyltransferase
AA650_RS09595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA650_RS09600	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AA650_RS09610	COG0505	Belongs to the CarA family
AA650_RS09630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA650_RS09680	COG1785	Belongs to the alkaline phosphatase family
AA650_RS09710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA650_RS09730	COG1530	ribonuclease E activity
AA650_RS09735	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AA650_RS09745	COG1605	Chorismate mutase
AA650_RS09745	COG0077	Prephenate dehydratase
AA650_RS09755	COG1136	(ABC) transporter
AA650_RS09755	COG0577	efflux transmembrane transporter activity
AA650_RS09775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA650_RS09790	COG0395	ABC-type sugar transport system, permease component
AA650_RS09805	COG2304	oxidoreductase activity
AA650_RS09810	COG0612	Peptidase, M16
AA650_RS09820	COG0748	coenzyme F420 binding
AA650_RS09830	COG0351	phosphomethylpyrimidine kinase
AA650_RS09840	COG0649	NAD binding
AA650_RS09865	COG0275	rRNA processing
AA650_RS09900	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AA650_RS09905	COG4251	negative regulation of phosphorylation
AA650_RS09915	COG2205	protein histidine kinase activity
AA650_RS09920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA650_RS09940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AA650_RS09960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA650_RS09970	COG0745	RESPONSE REGULATOR receiver
AA650_RS10015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AA650_RS10020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AA650_RS10040	COG1160	GTP binding
AA650_RS10045	COG1162	GTPase activity
AA650_RS10055	COG1487	ribonuclease activity
AA650_RS10060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA650_RS10070	COG2066	Belongs to the glutaminase family
AA650_RS10085	COG2885	chlorophyll binding
AA650_RS10110	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AA650_RS10115	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS10130	COG0758	DNA mediated transformation
AA650_RS10130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA650_RS10150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA650_RS10165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA650_RS10170	COG0134	indole-3-glycerol-phosphate synthase activity
AA650_RS10200	COG0745	RESPONSE REGULATOR receiver
AA650_RS10235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_RS10255	COG2255	four-way junction helicase activity
AA650_RS10295	COG3321	synthase
AA650_RS10295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA650_RS10295	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_RS10295	COG0300	oxidoreductase activity
AA650_RS10295	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_RS10315	COG0484	heat shock protein binding
AA650_RS10320	COG0740	serine-type endopeptidase activity
AA650_RS10325	COG0740	serine-type endopeptidase activity
AA650_RS10330	COG0740	serine-type endopeptidase activity
AA650_RS10345	COG1136	(ABC) transporter
AA650_RS10345	COG0577	efflux transmembrane transporter activity
AA650_RS10395	COG1122	ATPase activity
AA650_RS10400	COG0357	Ribosomal RNA small subunit methyltransferase G
AA650_RS10405	COG0196	riboflavin kinase activity
AA650_RS10420	COG0714	Associated with various cellular activities
AA650_RS10440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA650_RS10445	COG1408	metallophosphoesterase
AA650_RS10460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS10525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA650_RS10560	COG0003	Pfam Anion-transporting ATPase
AA650_RS10580	COG0006	proline dipeptidase activity
AA650_RS10585	COG3385	transposase activity
AA650_RS10615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA650_RS10640	COG0745	RESPONSE REGULATOR receiver
AA650_RS10645	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA650_RS10670	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA650_RS10675	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA650_RS10690	COG2815	serine threonine protein kinase
AA650_RS10690	COG0515	serine threonine protein kinase
AA650_RS10700	COG4948	Mandelate Racemase Muconate Lactonizing
AA650_RS10730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA650_RS10735	COG3266	domain, Protein
AA650_RS10735	COG0515	serine threonine protein kinase
AA650_RS10745	COG0575	Belongs to the CDS family
AA650_RS10755	COG1187	pseudouridine synthase activity
AA650_RS10760	COG1426	Protein conserved in bacteria
AA650_RS10765	COG1640	4-alpha-glucanotransferase
AA650_RS10775	COG0251	oxidation-reduction process
AA650_RS10785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA650_RS10785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AA650_RS10785	COG1013	pyruvate-flavodoxin oxidoreductase activity
AA650_RS10785	COG0674	pyruvate-flavodoxin oxidoreductase activity
AA650_RS10790	COG0464	growth
AA650_RS10805	COG2197	response regulator
AA650_RS10860	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AA650_RS10865	COG0668	transmembrane transport
AA650_RS10870	COG0668	transmembrane transport
AA650_RS10875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_RS10880	COG5002	protein histidine kinase activity
AA650_RS10890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AA650_RS10910	COG0237	dephospho-CoA kinase activity
AA650_RS10915	COG1587	Uroporphyrinogen-III synthase
AA650_RS10920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA650_RS10925	COG0745	RESPONSE REGULATOR receiver
AA650_RS10950	COG1131	(ABC) transporter
AA650_RS10950	COG1716	ATPase activity
AA650_RS10950	COG0842	Transport permease protein
AA650_RS10965	COG2198	Histidine kinase
AA650_RS10965	COG0643	Histidine kinase
AA650_RS10970	COG2203	Gaf domain
AA650_RS10970	COG0840	transmembrane signaling receptor activity
AA650_RS10985	COG2201	protein-glutamate methylesterase activity
AA650_RS10990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AA650_RS11005	COG0531	amino acid
AA650_RS11035	COG1234	tRNA 3'-trailer cleavage
AA650_RS11040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA650_RS11045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA650_RS11055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AA650_RS11060	COG0772	Belongs to the SEDS family
AA650_RS11070	COG0148	phosphopyruvate hydratase activity
AA650_RS11110	COG0577	efflux transmembrane transporter activity
AA650_RS11110	COG1136	(ABC) transporter
AA650_RS11125	COG0148	phosphopyruvate hydratase activity
AA650_RS11130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA650_RS11150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA650_RS11150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA650_RS11195	COG0408	coproporphyrinogen oxidase activity
AA650_RS11210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA650_RS11215	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AA650_RS11220	COG3385	transposase activity
AA650_RS11245	COG2084	Dehydrogenase
AA650_RS11250	COG0629	single-stranded DNA binding
AA650_RS11265	COG0577	efflux transmembrane transporter activity
AA650_RS11265	COG1136	(ABC) transporter
AA650_RS11285	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_RS11290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_RS11290	COG3320	Male sterility
AA650_RS11300	COG3239	Fatty acid desaturase
AA650_RS11305	COG3239	Fatty acid desaturase
AA650_RS11320	COG1136	(ABC) transporter
AA650_RS11330	COG0564	pseudouridine synthase activity
AA650_RS11345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA650_RS11365	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_RS11385	COG2205	protein histidine kinase activity
AA650_RS11385	COG3850	Histidine kinase
AA650_RS11385	COG3437	response regulator, receiver
AA650_RS11385	COG4999	Histidine kinase
AA650_RS11400	COG0481	GTPase activity
AA650_RS11405	COG0277	FAD linked oxidase domain protein
AA650_RS11410	COG0247	lactate metabolic process
AA650_RS11425	COG0515	serine threonine protein kinase
AA650_RS11425	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS11430	COG0572	uridine kinase
AA650_RS11435	COG2003	Belongs to the UPF0758 family
AA650_RS11440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AA650_RS11465	COG0516	GMP reductase activity
AA650_RS11465	COG0517	IMP dehydrogenase activity
AA650_RS11530	COG2234	aminopeptidase activity
AA650_RS11540	COG0438	transferase activity, transferring glycosyl groups
AA650_RS11590	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
AA650_RS11600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AA650_RS11660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_RS11675	COG0243	molybdopterin cofactor binding
AA650_RS11680	COG1116	anion transmembrane transporter activity
AA650_RS11685	COG1116	anion transmembrane transporter activity
AA650_RS11685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_RS11690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA650_RS11695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_RS11715	COG3385	transposase activity
AA650_RS11750	COG0523	cobalamin synthesis protein
AA650_RS11760	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS11765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA650_RS11770	COG0581	inorganic phosphate transmembrane transporter activity
AA650_RS11775	COG0573	inorganic phosphate transmembrane transporter activity
AA650_RS11785	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS11795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA650_RS11800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AA650_RS11805	COG0515	serine threonine protein kinase
AA650_RS11805	COG3266	domain, Protein
AA650_RS11870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA650_RS11885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA650_RS11895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA650_RS11895	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA650_RS11900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA650_RS11905	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA650_RS11930	COG0783	Belongs to the Dps family
AA650_RS11940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA650_RS11945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_RS11955	COG0494	nUDIX hydrolase
AA650_RS11970	COG1126	abc transporter atp-binding protein
AA650_RS11975	COG0765	amino acid transport
AA650_RS11980	COG4597	amino acid ABC transporter
AA650_RS11985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA650_RS11990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AA650_RS12005	COG4935	Belongs to the peptidase S8 family
AA650_RS12005	COG1404	Belongs to the peptidase S8 family
AA650_RS12030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA650_RS12040	COG0436	Aminotransferase
AA650_RS12050	COG1136	(ABC) transporter
AA650_RS12080	COG0384	phenazine biosynthesis protein PhzF
AA650_RS12095	COG0612	Peptidase, M16
AA650_RS12100	COG0612	Peptidase, M16
AA650_RS12105	COG0004	ammonium transporteR
AA650_RS12155	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AA650_RS12155	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AA650_RS12195	COG0616	signal peptide processing
AA650_RS12200	COG1304	FMN binding
AA650_RS12205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AA650_RS12210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AA650_RS12215	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA650_RS12220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA650_RS12220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA650_RS12225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA650_RS12230	COG1192	Involved in chromosome partitioning
AA650_RS12235	COG1196	nuclear chromosome segregation
AA650_RS12235	COG1674	ftsk spoiiie
AA650_RS12250	COG0095	Lipoate-protein ligase
AA650_RS12265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA650_RS12275	COG5002	protein histidine kinase activity
AA650_RS12285	COG0138	bifunctional purine biosynthesis protein purh
AA650_RS12315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AA650_RS12335	COG3536	Protein conserved in bacteria
AA650_RS12350	COG0515	serine threonine protein kinase
AA650_RS12350	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS12370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AA650_RS12380	COG0628	permease
AA650_RS12390	COG1316	TRANSCRIPTIONal
AA650_RS12405	COG0438	transferase activity, transferring glycosyl groups
AA650_RS12405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA650_RS12425	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_RS12435	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA650_RS12440	COG0515	serine threonine protein kinase
AA650_RS12440	COG3266	domain, Protein
AA650_RS12470	COG0515	serine threonine protein kinase
AA650_RS12470	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS12480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA650_RS12485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AA650_RS12495	COG0745	RESPONSE REGULATOR receiver
AA650_RS12500	COG3385	transposase activity
AA650_RS12510	COG0134	indole-3-glycerol-phosphate synthase activity
AA650_RS12515	COG1088	dTDP-glucose 4,6-dehydratase activity
AA650_RS12545	COG1943	Transposase
AA650_RS12555	COG0587	DNA-directed DNA polymerase activity
AA650_RS12595	COG0154	amidase activity
AA650_RS12600	COG1473	amidohydrolase
AA650_RS12605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AA650_RS12610	COG3266	domain, Protein
AA650_RS12610	COG0515	serine threonine protein kinase
AA650_RS12615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA650_RS12640	COG1217	gtp-binding protein TYPA
AA650_RS12650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS12655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AA650_RS12660	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AA650_RS12665	COG2211	Major facilitator Superfamily
AA650_RS12675	COG1053	succinate dehydrogenase
AA650_RS12680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS12690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS12715	COG0701	Predicted permease
AA650_RS12720	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
AA650_RS12735	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AA650_RS12765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA650_RS12770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA650_RS12780	COG0798	PFAM Bile acid sodium symporter
AA650_RS12785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AA650_RS12795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA650_RS12810	COG3118	belongs to the thioredoxin family
AA650_RS12820	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA650_RS12825	COG0830	nickel cation binding
AA650_RS12830	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AA650_RS12870	COG1657	PFAM Prenyltransferase squalene oxidase
AA650_RS12925	COG0024	Methionine aminopeptidase
AA650_RS12935	COG0612	Peptidase, M16
AA650_RS12960	COG0285	dihydrofolate synthase activity
AA650_RS12990	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AA650_RS13000	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AA650_RS13005	COG1959	2 iron, 2 sulfur cluster binding
AA650_RS13045	COG1091	dTDP-4-dehydrorhamnose reductase activity
AA650_RS13090	COG0469	pyruvate kinase activity
AA650_RS13100	COG3001	Fructosamine kinase
AA650_RS13120	COG1606	tRNA processing
AA650_RS13125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA650_RS13130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AA650_RS13135	COG0720	synthase
AA650_RS13170	COG0752	glycyl-tRNA synthetase alpha subunit
AA650_RS13180	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AA650_RS13190	COG0406	alpha-ribazole phosphatase activity
AA650_RS13205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AA650_RS13220	COG0438	transferase activity, transferring glycosyl groups
AA650_RS13230	COG1381	Involved in DNA repair and RecF pathway recombination
AA650_RS13245	COG0513	Belongs to the DEAD box helicase family
AA650_RS13255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AA650_RS13265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_RS13275	COG0303	'Molybdopterin
AA650_RS13280	COG3258	Cytochrome c
AA650_RS13285	COG0723	plastoquinol--plastocyanin reductase activity
AA650_RS13325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA650_RS13325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AA650_RS13330	COG1054	Belongs to the UPF0176 family
AA650_RS13350	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA650_RS13360	COG2267	carboxylic ester hydrolase activity
AA650_RS13375	COG0538	isocitrate dehydrogenase activity
AA650_RS13380	COG0515	serine threonine protein kinase
AA650_RS13385	COG0571	ribonuclease III activity
AA650_RS13395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA650_RS13400	COG1116	anion transmembrane transporter activity
AA650_RS13400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_RS13405	COG1116	anion transmembrane transporter activity
AA650_RS13420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_RS13435	COG4771	TonB-dependent receptor
AA650_RS13440	COG0826	peptidase U32
AA650_RS13485	COG0504	CTP synthase activity
AA650_RS13490	COG1940	carbohydrate kinase activity
AA650_RS13495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA650_RS13505	COG0750	zinc metalloprotease
AA650_RS13510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA650_RS13520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA650_RS13550	COG0651	ATP synthesis coupled electron transport
AA650_RS13555	COG1006	Multisubunit Na H antiporter MnhC subunit
AA650_RS13560	COG1982	Orn Lys Arg decarboxylase major
AA650_RS13590	COG3394	polysaccharide catabolic process
AA650_RS13660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA650_RS13670	COG0151	Belongs to the GarS family
AA650_RS13675	COG0475	glutathione-regulated potassium exporter activity
AA650_RS13675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA650_RS13705	COG0714	Associated with various cellular activities
AA650_RS13720	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AA650_RS13760	COG0457	Tetratricopeptide repeat
AA650_RS13765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA650_RS13780	COG0515	serine threonine protein kinase
AA650_RS13795	COG0439	Biotin carboxylase
AA650_RS13850	COG2197	response regulator
AA650_RS13860	COG1234	tRNA 3'-trailer cleavage
AA650_RS13865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA650_RS13875	COG1104	cysteine desulfurase activity
AA650_RS13880	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AA650_RS13890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA650_RS13910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA650_RS13950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS13955	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA650_RS13965	COG1785	Belongs to the alkaline phosphatase family
AA650_RS13975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AA650_RS13985	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_RS14000	COG0525	valine-tRNA ligase activity
AA650_RS14035	COG0534	Mate efflux family protein
AA650_RS14040	COG0436	Aminotransferase
AA650_RS14050	COG0837	glucose binding
AA650_RS14075	COG0217	transcriptional regulatory protein
AA650_RS14080	COG0322	excinuclease ABC activity
AA650_RS14085	COG0463	Glycosyl transferase, family 2
AA650_RS14085	COG0457	Tetratricopeptide repeat
AA650_RS14090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA650_RS14095	COG0436	Aminotransferase
AA650_RS14140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_RS14150	COG0561	phosphatase activity
AA650_RS14165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA650_RS14165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AA650_RS14185	COG0450	alkyl hydroperoxide reductase
AA650_RS14195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS14200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS14230	COG0484	heat shock protein binding
AA650_RS14240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AA650_RS14295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA650_RS14310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA650_RS14355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA650_RS14360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA650_RS14365	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA650_RS14370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AA650_RS14375	COG0584	glycerophosphoryl diester phosphodiesterase
AA650_RS14395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA650_RS14405	COG3385	transposase activity
AA650_RS14465	COG2852	Protein conserved in bacteria
AA650_RS14490	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS14500	COG2161	toxin-antitoxin pair type II binding
AA650_RS14505	COG4115	mRNA cleavage
AA650_RS14515	COG4658	electron transport chain
AA650_RS14530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS14540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA650_RS14545	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_RS14550	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_RS14555	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
AA650_RS14560	COG4451	ribulose bisphosphate carboxylase, small
AA650_RS14560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA650_RS14565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA650_RS14570	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_RS14575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA650_RS14585	COG0583	DNA-binding transcription factor activity
AA650_RS14660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA650_RS14680	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA650_RS14685	COG2217	Heavy metal translocating P-type atpase
AA650_RS14695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA650_RS14730	COG0708	Exodeoxyribonuclease III
AA650_RS14765	COG1175	transmembrane transport
AA650_RS14795	COG0475	glutathione-regulated potassium exporter activity
AA650_RS14800	COG0488	(ABC) transporter
AA650_RS14825	COG0308	aminopeptidase N
AA650_RS14850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA650_RS14875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA650_RS14905	COG3848	Pyruvate phosphate dikinase
AA650_RS14905	COG0574	Belongs to the PEP-utilizing enzyme family
AA650_RS14920	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_RS14945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AA650_RS14965	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA650_RS14970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AA650_RS14990	COG3118	belongs to the thioredoxin family
AA650_RS14995	COG0563	adenylate kinase activity
AA650_RS15035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA650_RS15045	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS15115	COG0746	molybdenum cofactor guanylyltransferase activity
AA650_RS15125	COG2501	S4 domain
AA650_RS15180	COG0776	regulation of translation
AA650_RS15190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA650_RS15205	COG0534	Mate efflux family protein
AA650_RS15210	COG0494	nUDIX hydrolase
AA650_RS15255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AA650_RS15265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_RS15270	COG0432	Pfam Uncharacterised protein family UPF0047
AA650_RS15290	COG0561	phosphatase activity
AA650_RS15295	COG2197	response regulator
AA650_RS15310	COG0859	PFAM glycosyl transferase family 9
AA650_RS15315	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AA650_RS15330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS15340	COG2304	oxidoreductase activity
AA650_RS15345	COG2304	oxidoreductase activity
AA650_RS15380	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AA650_RS15385	COG0298	carbon dioxide binding
AA650_RS15390	COG0409	Hydrogenase expression formation protein
AA650_RS15405	COG0375	protein maturation
AA650_RS15415	COG2226	methyltransferase
AA650_RS15425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA650_RS15470	COG0582	viral genome integration into host DNA
AA650_RS15525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AA650_RS15530	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AA650_RS15540	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA650_RS15600	COG1518	maintenance of DNA repeat elements
AA650_RS15605	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AA650_RS15640	COG0157	Belongs to the NadC ModD family
AA650_RS15645	COG0436	Aminotransferase
AA650_RS15650	COG3118	belongs to the thioredoxin family
AA650_RS15665	COG1842	Phage shock protein A
AA650_RS15670	COG1842	Phage shock protein A
AA650_RS15690	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AA650_RS15695	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AA650_RS15710	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS15715	COG0515	serine threonine protein kinase
AA650_RS15715	COG3266	domain, Protein
AA650_RS15750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA650_RS15760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA650_RS15790	COG2217	Heavy metal translocating P-type atpase
AA650_RS15800	COG1090	epimerase
AA650_RS15810	COG0583	DNA-binding transcription factor activity
AA650_RS15820	COG3118	belongs to the thioredoxin family
AA650_RS15825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA650_RS15860	COG4451	ribulose bisphosphate carboxylase, small
AA650_RS15870	COG1850	ribulose-bisphosphate carboxylase activity
AA650_RS15880	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA650_RS15935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA650_RS15940	COG0438	transferase activity, transferring glycosyl groups
AA650_RS15945	COG1177	transmembrane transport
AA650_RS15960	COG1160	GTP binding
AA650_RS15970	COG2912	Transglutaminase-like superfamily
AA650_RS15985	COG3385	transposase activity
AA650_RS15995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA650_RS16000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA650_RS16035	COG2319	Wd-40 repeat
AA650_RS16035	COG3903	Transcriptional regulator
AA650_RS16100	COG1136	(ABC) transporter
AA650_RS16100	COG0577	efflux transmembrane transporter activity
AA650_RS16105	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_RS16120	COG3385	transposase activity
AA650_RS16145	COG3311	Transcriptional regulator
AA650_RS16150	COG1569	PIN domain
AA650_RS16195	COG4644	lycopene metabolic process
AA650_RS16285	COG4974	Belongs to the 'phage' integrase family
AA650_RS16320	COG1192	Involved in chromosome partitioning
AA650_RS16325	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA650_RS16365	COG1475	DNA binding
AA650_RS16370	COG1192	Involved in chromosome partitioning
AA650_RS16480	COG0534	Mate efflux family protein
AA650_RS16485	COG2192	nodulation
AA650_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_RS16520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA650_RS16525	COG0459	protein refolding
AA650_RS16535	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AA650_RS16540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA650_RS16575	COG2885	chlorophyll binding
AA650_RS16575	COG3047	cAMP biosynthetic process
AA650_RS16585	COG0012	GTP binding
AA650_RS16620	COG0793	Belongs to the peptidase S41A family
AA650_RS16625	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_RS16625	COG0515	serine threonine protein kinase
AA650_RS16635	COG0850	regulation of cytokinetic process
AA650_RS16640	COG2894	cell division
AA650_RS16645	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AA650_RS16650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AA650_RS16670	COG0670	Belongs to the BI1 family
AA650_RS16685	COG3239	Fatty acid desaturase
AA650_RS16695	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AA650_RS16705	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
AA650_RS16745	COG2119	membrane
AA650_RS16765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AA650_RS16765	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AA650_RS16775	COG2373	Large extracellular alpha-helical protein
AA650_RS16780	COG4953	penicillin-binding protein 1C
AA650_RS16805	COG0571	ribonuclease III activity
AA650_RS16810	COG1672	PFAM Archaeal ATPase
AA650_RS16815	COG0724	RNA recognition motif
AA650_RS16820	COG0724	RNA recognition motif
AA650_RS16835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA650_RS16845	COG1543	Belongs to the glycosyl hydrolase 57 family
AA650_RS16855	COG1162	GTPase activity
AA650_RS16865	COG0484	heat shock protein binding
AA650_RS16870	COG0443	Heat shock 70 kDa protein
AA650_RS16885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA650_RS16890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AA650_RS16900	COG1459	type II secretion system
AA650_RS16925	COG3854	ATPases associated with a variety of cellular activities
AA650_RS16950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA650_RS16965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA650_RS16970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS16985	COG0802	atpase or kinase
AA650_RS16995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AA650_RS17000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA650_RS17030	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA650_RS17080	COG1566	PFAM secretion protein HlyD family protein
AA650_RS17090	COG1136	(ABC) transporter
AA650_RS17090	COG0577	efflux transmembrane transporter activity
AA650_RS17110	COG2385	sporulation resulting in formation of a cellular spore
AA650_RS17115	COG0489	protein tyrosine kinase activity
AA650_RS17140	COG1252	NADH dehydrogenase
AA650_RS17150	COG0534	Mate efflux family protein
AA650_RS17165	COG1819	glycosyl
AA650_RS17185	COG0284	orotidine-5'-phosphate decarboxylase activity
AA650_RS17185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA650_RS17190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA650_RS17195	COG1104	cysteine desulfurase activity
AA650_RS17235	COG1487	ribonuclease activity
AA650_RS17265	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AA650_RS17285	COG0799	negative regulation of ribosome biogenesis
AA650_RS17305	COG1494	fructose-1,6-bisphosphatase
AA650_RS17310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA650_RS17330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AA650_RS17335	COG0724	RNA recognition motif
AA650_RS17350	COG1696	Membrane protein involved in D-alanine export
AA650_RS17360	COG1943	Transposase
AA650_RS17420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA650_RS17435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AA650_RS17435	COG0574	Belongs to the PEP-utilizing enzyme family
AA650_RS17440	COG0469	pyruvate kinase activity
AA650_RS17445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA650_RS17455	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AA650_RS17475	COG4680	protein conserved in bacteria
AA650_RS17495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA650_RS17500	COG0601	transmembrane transport
AA650_RS17525	COG0438	transferase activity, transferring glycosyl groups
AA650_RS17535	COG0438	transferase activity, transferring glycosyl groups
AA650_RS17540	COG3842	ATPase activity
AA650_RS17580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA650_RS17580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA650_RS17595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA650_RS17615	COG1027	Aspartate ammonia-lyase
AA650_RS17635	COG0438	transferase activity, transferring glycosyl groups
AA650_RS17670	COG0500	methyltransferase
AA650_RS17675	COG1215	transferase activity, transferring glycosyl groups
AA650_RS17680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_RS17715	COG0003	Pfam Anion-transporting ATPase
AA650_RS17720	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AA650_RS17750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA650_RS17755	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AA650_RS17760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA650_RS17775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_RS17780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA650_RS17785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_RS17785	COG1116	anion transmembrane transporter activity
AA650_RS17790	COG1116	anion transmembrane transporter activity
AA650_RS17795	COG4636	protein conserved in cyanobacteria
AA650_RS17835	COG1252	NADH dehydrogenase
AA650_RS17850	COG0398	Pfam SNARE associated Golgi protein
AA650_RS17875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA650_RS17910	COG1615	UPF0182 protein
AA650_RS17915	COG1797	cobyrinic acid a,c-diamide synthase activity
AA650_RS17925	COG2201	protein-glutamate methylesterase activity
AA650_RS17930	COG2326	polyphosphate kinase activity
AA650_RS17935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA650_RS17950	COG0415	Belongs to the DNA photolyase family
AA650_RS17955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA650_RS17975	COG2203	Gaf domain
AA650_RS17995	COG2274	protein secretion by the type I secretion system
AA650_RS18010	COG0010	Belongs to the arginase family
AA650_RS18015	COG2264	protein methyltransferase activity
AA650_RS18020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA650_RS18025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AA650_RS18030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA650_RS18045	COG0842	Transport permease protein
AA650_RS18050	COG0842	Transport permease protein
AA650_RS18050	COG1129	ABC transporter
AA650_RS18055	COG1131	(ABC) transporter
AA650_RS18060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA650_RS18075	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA650_RS18080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA650_RS18085	COG0085	RNA polymerase activity
AA650_RS18090	COG0084	hydrolase, TatD family'
AA650_RS18095	COG0268	Binds directly to 16S ribosomal RNA
AA650_RS18100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AA650_RS18120	COG2119	membrane
AA650_RS18125	COG2226	methyltransferase
AA650_RS18140	COG0515	serine threonine protein kinase
AA650_RS18140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_RS18150	COG2226	methyltransferase
AA650_RS18155	COG0482	sulfurtransferase activity
AA650_RS18165	COG0424	maF-like protein
AA650_RS18190	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS18195	COG2886	Uncharacterised protein family (UPF0175)
AA650_RS18250	COG0633	Ferredoxin
AA650_RS18255	COG0316	Belongs to the HesB IscA family
AA650_RS18260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA650_RS18270	COG5420	small protein containing a coiled-coil domain
AA650_RS18285	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_RS18290	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_RS18295	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_RS18320	COG0582	viral genome integration into host DNA
AA650_RS18330	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS18370	COG4221	oxidoreductase activity
AA650_RS18385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA650_RS18425	COG3903	Transcriptional regulator
AA650_RS18425	COG2319	Wd-40 repeat
AA650_RS18465	COG2319	Wd-40 repeat
AA650_RS18465	COG3903	Transcriptional regulator
AA650_RS18475	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AA650_RS18480	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AA650_RS18485	COG0582	viral genome integration into host DNA
AA650_RS18530	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AA650_RS18575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_RS18615	COG3119	arylsulfatase activity
AA650_RS18620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA650_RS18635	COG3385	transposase activity
AA650_RS18665	COG1132	(ABC) transporter
AA650_RS18670	COG0667	Aldo Keto reductase
AA650_RS18685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA650_RS18690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA650_RS18740	COG0625	glutathione transferase activity
AA650_RS18830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA650_RS18835	COG2873	o-acetylhomoserine
AA650_RS18840	COG0412	Dienelactone hydrolase
AA650_RS18845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_RS18850	COG4221	oxidoreductase activity
AA650_RS18860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_RS18865	COG1285	pathogenesis
AA650_RS18870	COG5002	protein histidine kinase activity
AA650_RS18890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA650_RS18900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA650_RS18905	COG1028	Short-chain dehydrogenase reductase Sdr
AA650_RS18930	COG0667	Aldo Keto reductase
AA650_RS18935	COG3659	wide pore channel activity
AA650_RS18940	COG0778	Nitroreductase
AA650_RS18950	COG1116	anion transmembrane transporter activity
AA650_RS18960	COG2175	clavaminate synthase activity
AA650_RS18965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA650_RS18970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA650_RS18975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA650_RS18980	COG0431	NADPH-dependent FMN reductase
AA650_RS19005	COG0730	response to heat
AA650_RS19025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA650_RS19030	COG1959	2 iron, 2 sulfur cluster binding
AA650_RS19035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_RS19090	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AA650_RS19095	COG0822	iron-sulfur transferase activity
AA650_RS19095	COG2906	2 iron, 2 sulfur cluster binding
AA650_RS19095	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA650_RS19100	COG1104	cysteine desulfurase activity
AA650_RS19105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AA650_RS19120	COG1045	serine acetyltransferase
AA650_RS19135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA650_RS19140	COG5554	nitrogen fixation
AA650_RS19145	COG5554	nitrogen fixation
AA650_RS19165	COG0442	prolyl-tRNA aminoacylation
AA650_RS19170	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS19170	COG0515	serine threonine protein kinase
AA650_RS19195	COG0534	Mate efflux family protein
AA650_RS19200	COG1902	pentaerythritol trinitrate reductase activity
AA650_RS19205	COG4638	Rieske (2fe-2S)
AA650_RS19225	COG0604	alcohol dehydrogenase
AA650_RS19225	COG3321	synthase
AA650_RS19225	COG3321	synthase
AA650_RS19225	COG0604	alcohol dehydrogenase
AA650_RS19235	COG3321	synthase
AA650_RS19235	COG0604	alcohol dehydrogenase
AA650_RS19245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA650_RS19250	COG1960	acyl-CoA dehydrogenase activity
AA650_RS19270	COG0511	ligase activity, forming carbon-carbon bonds
AA650_RS19275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA650_RS19285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AA650_RS19295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AA650_RS19300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA650_RS19305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA650_RS19310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA650_RS19315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA650_RS19320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA650_RS19330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS19340	COG0358	DNA primase activity
AA650_RS19360	COG3385	transposase activity
AA650_RS19365	COG4585	Histidine kinase
AA650_RS19390	COG4572	Cation transport regulator
AA650_RS19395	COG0783	Belongs to the Dps family
AA650_RS19400	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AA650_RS19420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_RS19435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AA650_RS19465	COG0793	Belongs to the peptidase S41A family
AA650_RS19475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AA650_RS19495	COG0019	diaminopimelate decarboxylase activity
AA650_RS19500	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AA650_RS19505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA650_RS19515	COG0484	heat shock protein binding
AA650_RS19540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA650_RS19545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AA650_RS19550	COG0508	dehydrogenase complex catalyzes the overall conversion of
AA650_RS19550	COG0022	dehydrogenase e1 component
AA650_RS19575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AA650_RS19605	COG3385	transposase activity
AA650_RS19630	COG1063	alcohol dehydrogenase
AA650_RS19640	COG3311	Transcriptional regulator
AA650_RS19645	COG0515	serine threonine protein kinase
AA650_RS19645	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS19705	COG0495	leucyl-tRNA aminoacylation
AA650_RS19710	COG2124	cytochrome p450
AA650_RS19740	COG2267	carboxylic ester hydrolase activity
AA650_RS19750	COG4636	protein conserved in cyanobacteria
AA650_RS19780	COG3385	transposase activity
AA650_RS19810	COG4581	dead DEAH box helicase
AA650_RS19880	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AA650_RS19895	COG0612	Peptidase, M16
AA650_RS19935	COG0438	transferase activity, transferring glycosyl groups
AA650_RS19955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_RS19970	COG0463	Glycosyl transferase, family 2
AA650_RS19990	COG0667	Aldo Keto reductase
AA650_RS20000	COG0352	thiamine-phosphate diphosphorylase activity
AA650_RS20015	COG1361	Conserved repeat domain
AA650_RS20030	COG1468	defense response to virus
AA650_RS20030	COG1518	maintenance of DNA repeat elements
AA650_RS20065	COG3385	transposase activity
AA650_RS20080	COG0154	amidase activity
AA650_RS20125	COG3240	lipase activity
AA650_RS20165	COG0584	glycerophosphoryl diester phosphodiesterase
AA650_RS20205	COG0501	Belongs to the peptidase M48B family
AA650_RS20210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA650_RS20235	COG0488	(ABC) transporter
AA650_RS20245	COG1132	(ABC) transporter
AA650_RS20255	COG0300	oxidoreductase activity
AA650_RS20255	COG3000	fatty acid hydroxylase
AA650_RS20260	COG4245	von Willebrand factor, type A
AA650_RS20265	COG2319	Wd-40 repeat
AA650_RS20265	COG4249	Peptidase C14 caspase catalytic subunit p20
AA650_RS20315	COG1487	ribonuclease activity
AA650_RS20395	COG0556	nucleotide-excision repair
AA650_RS20405	COG4636	protein conserved in cyanobacteria
AA650_RS20430	COG0419	ATPase involved in DNA repair
AA650_RS20445	COG2223	nitrite transmembrane transporter activity
AA650_RS20475	COG1968	undecaprenyl-diphosphatase activity
AA650_RS20490	COG1555	photosystem II stabilization
AA650_RS20495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA650_RS20530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AA650_RS20535	COG4243	Vitamin k epoxide reductase
AA650_RS20540	COG0434	BtpA family
AA650_RS20545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA650_RS20550	COG0513	Belongs to the DEAD box helicase family
AA650_RS20590	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS20665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA650_RS20670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AA650_RS20675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA650_RS20680	COG0735	belongs to the Fur family
AA650_RS20685	COG3409	Peptidoglycan-binding domain 1 protein
AA650_RS20685	COG3773	Cell wall hydrolase
AA650_RS20725	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AA650_RS20735	COG0857	belongs to the CobB CobQ family
AA650_RS20790	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS20800	COG1215	transferase activity, transferring glycosyl groups
AA650_RS20830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS20855	COG0589	response to stress
AA650_RS20860	COG2205	protein histidine kinase activity
AA650_RS20875	COG0725	ABC transporter, periplasmic molybdate-binding protein
AA650_RS20880	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA650_RS20885	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AA650_RS20895	COG0811	peptide transport
AA650_RS20900	COG0848	biopolymer transport protein
AA650_RS20915	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AA650_RS20935	COG2046	Belongs to the sulfate adenylyltransferase family
AA650_RS20950	COG0793	Belongs to the peptidase S41A family
AA650_RS20990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA650_RS21005	COG0181	hydroxymethylbilane synthase activity
AA650_RS21010	COG0297	glycogen (starch) synthase activity
AA650_RS21020	COG0523	cobalamin synthesis protein
AA650_RS21025	COG0215	cysteine-tRNA ligase activity
AA650_RS21045	COG4251	negative regulation of phosphorylation
AA650_RS21045	COG4251	negative regulation of phosphorylation
AA650_RS21050	COG0277	FAD linked oxidase domain protein
AA650_RS21055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AA650_RS21065	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AA650_RS21070	COG4221	oxidoreductase activity
AA650_RS21075	COG0156	8-amino-7-oxononanoate synthase activity
AA650_RS21080	COG0632	four-way junction helicase activity
AA650_RS21085	COG0561	phosphatase activity
AA650_RS21090	COG0561	phosphatase activity
AA650_RS21150	COG1722	exodeoxyribonuclease VII activity
AA650_RS21195	COG0589	response to stress
AA650_RS21200	COG0126	phosphoglycerate kinase activity
AA650_RS21205	COG4636	protein conserved in cyanobacteria
AA650_RS21210	COG2208	phosphoserine phosphatase activity
AA650_RS21245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA650_RS21250	COG0805	protein transport
AA650_RS21285	COG0515	serine threonine protein kinase
AA650_RS21290	COG0515	serine threonine protein kinase
AA650_RS21290	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS21300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA650_RS21320	COG1012	belongs to the aldehyde dehydrogenase family
AA650_RS21330	COG0140	phosphoribosyl-ATP diphosphatase activity
AA650_RS21330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AA650_RS21335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA650_RS21345	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS21345	COG0515	serine threonine protein kinase
AA650_RS21405	COG0037	tRNA processing
AA650_RS21415	COG0784	Response regulator, receiver
AA650_RS21440	COG2198	Histidine kinase
AA650_RS21440	COG0643	Histidine kinase
AA650_RS21440	COG2198	Histidine kinase
AA650_RS21440	COG0643	Histidine kinase
AA650_RS21455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA650_RS21460	COG0745	RESPONSE REGULATOR receiver
AA650_RS21465	COG3385	transposase activity
AA650_RS21475	COG1007	ATP synthesis coupled electron transport
AA650_RS21555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AA650_RS21555	COG1754	DNA topoisomerase type I activity
AA650_RS21565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AA650_RS21575	COG1480	7TM receptor with intracellular HD hydrolase
AA650_RS21610	COG0307	riboflavin synthase, alpha
AA650_RS21620	COG4942	peptidase
AA650_RS21625	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AA650_RS21625	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AA650_RS21630	COG1496	oxidoreductase activity
AA650_RS21650	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AA650_RS21655	COG0519	Catalyzes the synthesis of GMP from XMP
AA650_RS21655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA650_RS21660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AA650_RS21665	COG0189	ligase activity
AA650_RS21675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA650_RS21720	COG4447	cellulose binding
AA650_RS21725	COG1773	rubredoxin
AA650_RS21730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS21735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS21740	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA650_RS21745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA650_RS21760	COG2890	protein-(glutamine-N5) methyltransferase activity
AA650_RS21765	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS21765	COG0515	serine threonine protein kinase
AA650_RS21780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA650_RS21800	COG0360	Binds together with S18 to 16S ribosomal RNA
AA650_RS21810	COG0587	DNA-directed DNA polymerase activity
AA650_RS21890	COG0542	response to heat
AA650_RS21905	COG0109	protoheme IX farnesyltransferase activity
AA650_RS21915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA650_RS21920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA650_RS21925	COG1845	cytochrome c oxidase, subunit III
AA650_RS21940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AA650_RS21950	COG2197	response regulator
AA650_RS21960	COG1489	DNA binding
AA650_RS21975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA650_RS21980	COG3321	synthase
AA650_RS21980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_RS21980	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AA650_RS21980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_RS21985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA650_RS21990	COG1981	membrane
AA650_RS22000	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AA650_RS22010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA650_RS22015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AA650_RS22060	COG0436	Aminotransferase
AA650_RS22065	COG0371	Dehydrogenase
AA650_RS22080	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AA650_RS22105	COG1666	GTP binding
AA650_RS22110	COG0625	glutathione transferase activity
AA650_RS22140	COG1070	Carbohydrate kinase
AA650_RS22150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA650_RS22185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA650_RS22190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA650_RS22195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA650_RS22200	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AA650_RS22205	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA650_RS22210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AA650_RS22215	COG1410	methionine synthase
AA650_RS22215	COG0646	methionine synthase
AA650_RS22225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA650_RS22240	COG1012	belongs to the aldehyde dehydrogenase family
AA650_RS22245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA650_RS22270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA650_RS22275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AA650_RS22280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA650_RS22285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AA650_RS22290	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA650_RS22295	COG0740	serine-type endopeptidase activity
AA650_RS22300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA650_RS22390	COG1836	PFAM Integral membrane protein DUF92
AA650_RS22405	COG1940	carbohydrate kinase activity
AA650_RS22430	COG2082	Precorrin-8x methylmutase
AA650_RS22440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA650_RS22490	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA650_RS22500	COG0343	queuine tRNA-ribosyltransferase activity
AA650_RS22545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA650_RS22565	COG0667	Aldo Keto reductase
AA650_RS22570	COG0537	adenosine 5'-monophosphoramidase activity
AA650_RS22590	COG0606	chelatase, subunit chli
AA650_RS22595	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AA650_RS22610	COG0673	inositol 2-dehydrogenase activity
AA650_RS22615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA650_RS22625	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AA650_RS22635	COG0133	tryptophan synthase activity
AA650_RS22640	COG0515	serine threonine protein kinase
AA650_RS22640	COG1357	PFAM Pentapeptide repeats (8 copies)
AA650_RS22675	COG0023	Translation Initiation Factor
AA650_RS22680	COG2161	toxin-antitoxin pair type II binding
AA650_RS22695	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AA650_RS22700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA650_RS22715	COG0768	penicillin binding
AA650_RS22745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA650_RS22775	COG0191	fructose-bisphosphate aldolase activity
AA650_RS22815	COG1122	ATPase activity
AA650_RS22830	COG1247	-acetyltransferase
AA650_RS22835	COG0746	molybdenum cofactor guanylyltransferase activity
AA650_RS22840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AA650_RS22845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA650_RS22850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AA650_RS22855	COG2080	2 iron, 2 sulfur cluster binding
AA650_RS22860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AA650_RS22880	COG1649	PFAM Uncharacterised BCR, COG1649
AA650_RS22900	COG0535	radical SAM domain protein
AA650_RS22940	COG0497	DNA recombination
AA650_RS22955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AA650_RS22960	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA650_RS22970	COG0159	tryptophan synthase activity
AA650_RS22985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA650_RS22990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA650_RS23010	COG0501	Belongs to the peptidase M48B family
AA650_RS23015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AA650_RS23040	COG1895	HEPN domain
AA650_RS23050	COG1396	sequence-specific DNA binding
AA650_RS23055	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AA650_RS23060	COG4636	protein conserved in cyanobacteria
AA650_RS23065	COG0300	oxidoreductase activity
AA650_RS23090	COG0302	gtp cyclohydrolase
AA650_RS23095	COG0523	cobalamin synthesis protein
AA650_RS23105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA650_RS23125	COG0675	Transposase, IS605 OrfB family
AA650_RS23135	COG0113	porphobilinogen synthase activity
AA650_RS23140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA650_RS23140	COG2022	thiamine diphosphate biosynthetic process
AA650_RS23155	COG1388	LysM domain
AA650_RS23155	COG1376	ErfK ybiS ycfS ynhG family protein
AA650_RS23160	COG1595	DNA-templated transcription, initiation
AA650_RS23215	COG0459	protein refolding
AA650_RS23220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA650_RS23225	COG0745	RESPONSE REGULATOR receiver
AA650_RS23230	COG4636	protein conserved in cyanobacteria
AA650_RS23240	COG0829	nickel cation binding
AA650_RS23245	COG0831	urea catabolic process
AA650_RS23260	COG0832	Belongs to the urease beta subunit family
AA650_RS23265	COG0804	urea catabolic process
AA650_RS23270	COG0739	heme binding
AA650_RS23280	COG1131	(ABC) transporter
AA650_RS23290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA650_RS23310	COG0017	Asparaginyl-tRNA synthetase
AA650_RS23325	COG0515	serine threonine protein kinase
AA650_RS23325	COG3266	domain, Protein
AA650_RS23335	COG3385	transposase activity
AA650_RS23345	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AA650_RS23350	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AA650_RS23360	COG0228	four-way junction DNA binding
AA650_RS23370	COG1702	phosphate starvation-inducible protein PhoH
AA650_RS23455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA650_RS23460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AA650_RS23465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA650_RS23470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA650_RS23475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA650_RS23480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA650_RS23485	COG0356	it plays a direct role in the translocation of protons across the membrane
AA650_RS23495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA650_RS23505	COG3385	transposase activity
AA650_RS23510	COG3385	transposase activity
AA650_RS23515	COG3385	transposase activity
AA650_RS23520	COG1401	restriction endodeoxyribonuclease activity
AA650_RS23535	COG0765	amino acid transport
AA650_RS23550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA650_RS23585	COG2226	methyltransferase
AA650_RS23590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA650_RS23605	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_RS23610	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_RS23640	COG3903	Transcriptional regulator
AA650_RS23640	COG2319	Wd-40 repeat
AA650_RS23645	COG2988	succinylglutamate desuccinylase activity
AA650_RS23650	COG0438	transferase activity, transferring glycosyl groups
AA650_RS23660	COG2319	Wd-40 repeat
AA650_RS23665	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AA650_RS23670	COG3906	Belongs to the UPF0473 family
AA650_RS23675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA650_RS23695	COG0793	Belongs to the peptidase S41A family
AA650_RS23700	COG2045	Belongs to the ComB family
AA650_RS23705	COG2363	Small membrane protein
AA650_RS23715	COG0390	transport system, permease component
AA650_RS23750	COG5002	protein histidine kinase activity
AA650_RS23780	COG1216	Glycosyl transferase, family 2
AA650_RS23785	COG1132	(ABC) transporter
AA650_RS23800	COG0489	protein tyrosine kinase activity
AA650_RS23830	COG1216	Glycosyl transferase, family 2
AA650_RS23835	COG1216	Glycosyl transferase, family 2
AA650_RS23840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA650_RS23845	COG0579	oxidoreductase
AA650_RS23850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AA650_RS23870	COG4245	von Willebrand factor, type A
AA650_RS23875	COG0784	Response regulator, receiver
AA650_RS23955	COG1690	Belongs to the RtcB family
AA650_RS23965	COG1361	Conserved repeat domain
AA650_RS23975	COG0113	porphobilinogen synthase activity
AA650_RS23985	COG0735	belongs to the Fur family
AA650_RS23990	COG0678	peroxiredoxin activity
AA650_RS24040	COG0166	Belongs to the GPI family
AA650_RS24060	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS24065	COG1160	GTP binding
AA650_RS24085	COG5635	Nacht domain
AA650_RS24085	COG2319	Wd-40 repeat
AA650_RS24125	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AA650_RS24135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AA650_RS24140	COG0501	Belongs to the peptidase M48B family
AA650_RS24150	COG0297	glycogen (starch) synthase activity
AA650_RS24160	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AA650_RS24170	COG3659	wide pore channel activity
AA650_RS24175	COG0803	Belongs to the bacterial solute-binding protein 9 family
AA650_RS24180	COG1121	(ABC) transporter
AA650_RS24185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA650_RS24260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA650_RS24300	COG0339	signal peptide processing
AA650_RS24335	COG1429	ligase activity, forming nitrogen-metal bonds
AA650_RS24345	COG4636	protein conserved in cyanobacteria
AA650_RS24460	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA650_RS24470	COG0668	transmembrane transport
AA650_RS24475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS24480	COG1937	Protein conserved in bacteria
AA650_RS24500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AA650_RS24530	COG0675	Transposase, IS605 OrfB family
AA650_RS24555	COG0024	Methionine aminopeptidase
AA650_RS24560	COG0673	inositol 2-dehydrogenase activity
AA650_RS24595	COG0633	Ferredoxin
AA650_RS24600	COG2385	sporulation resulting in formation of a cellular spore
AA650_RS24610	COG1366	Belongs to the anti-sigma-factor antagonist family
AA650_RS24615	COG0745	RESPONSE REGULATOR receiver
AA650_RS24635	COG0107	imidazoleglycerol-phosphate synthase activity
AA650_RS24650	COG1185	polyribonucleotide nucleotidyltransferase activity
AA650_RS24655	COG2223	nitrite transmembrane transporter activity
AA650_RS24720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA650_RS24740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA650_RS24745	COG0193	aminoacyl-tRNA hydrolase activity
AA650_RS24755	COG1216	Glycosyl transferase, family 2
AA650_RS24760	COG0137	argininosuccinate synthase activity
AA650_RS24765	COG0586	Pfam SNARE associated Golgi protein
AA650_RS24775	COG2255	four-way junction helicase activity
AA650_RS24780	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AA650_RS24800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA650_RS24805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA650_RS24815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS24825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS24845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA650_RS24850	COG0210	DNA helicase
AA650_RS24865	COG2815	serine threonine protein kinase
AA650_RS24865	COG0515	serine threonine protein kinase
AA650_RS24875	COG2226	methyltransferase
AA650_RS24880	COG4399	Belongs to the UPF0754 family
AA650_RS24890	COG0426	domain, Protein
AA650_RS24890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA650_RS24895	COG0426	domain, Protein
AA650_RS24895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AA650_RS24905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA650_RS24905	COG2755	lipolytic protein G-D-S-L family
AA650_RS24910	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AA650_RS24920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS24950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA650_RS24975	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS25005	COG0542	response to heat
AA650_RS25010	COG0346	lactoylglutathione lyase activity
AA650_RS25025	COG0653	protein targeting
AA650_RS25035	COG2010	Cytochrome c
AA650_RS25045	COG0742	ribosomal rna small subunit methyltransferase
AA650_RS25050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA650_RS25070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AA650_RS25075	COG0438	transferase activity, transferring glycosyl groups
AA650_RS25085	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AA650_RS25090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA650_RS25095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AA650_RS25100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA650_RS25125	COG0745	RESPONSE REGULATOR receiver
AA650_RS25200	COG1598	PFAM Uncharacterised protein family UPF0150
AA650_RS25225	COG1429	ligase activity, forming nitrogen-metal bonds
AA650_RS25305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA650_RS25310	COG0702	epimerase
AA650_RS25320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA650_RS25325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AA650_RS25335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA650_RS25340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA650_RS25345	COG2048	Heterodisulfide reductase, subunit B
AA650_RS25350	COG0242	peptide deformylase activity
AA650_RS25360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA650_RS25460	COG1309	transcriptional regulator
AA650_RS25465	COG1136	(ABC) transporter
AA650_RS25490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA650_RS25495	COG0604	alcohol dehydrogenase
AA650_RS25495	COG3321	synthase
AA650_RS25495	COG0604	alcohol dehydrogenase
AA650_RS25495	COG3321	synthase
AA650_RS25510	COG0318	PFAM AMP-dependent synthetase and ligase
AA650_RS25565	COG4974	Belongs to the 'phage' integrase family
AA650_RS25620	COG1475	DNA binding
AA650_RS25625	COG1192	Involved in chromosome partitioning
AA650_RS25630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AA650_RS25730	COG4474	Belongs to the UPF0398 family
AA650_RS25805	COG0776	regulation of translation