locus-tag	class	description
AWH56_RS00005	COG1940	carbohydrate kinase activity
AWH56_RS00010	COG3842	ATPase activity
AWH56_RS00030	COG0697	spore germination
AWH56_RS00035	COG1363	Peptidase, m42
AWH56_RS00045	COG0457	Tetratricopeptide repeat
AWH56_RS00045	COG0705	Rhomboid family
AWH56_RS00065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AWH56_RS00070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWH56_RS00085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AWH56_RS00090	COG1543	Belongs to the glycosyl hydrolase 57 family
AWH56_RS00115	COG0768	penicillin binding
AWH56_RS00120	COG0477	Major facilitator Superfamily
AWH56_RS00125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWH56_RS00130	COG1968	undecaprenyl-diphosphatase activity
AWH56_RS00165	COG5521	maltodextrose utilization protein MalA
AWH56_RS00175	COG4086	secreted protein
AWH56_RS00180	COG2814	Major facilitator Superfamily
AWH56_RS00185	COG1388	LysM domain
AWH56_RS00190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AWH56_RS00200	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AWH56_RS00205	COG0735	belongs to the Fur family
AWH56_RS00210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWH56_RS00215	COG1121	(ABC) transporter
AWH56_RS00225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWH56_RS00230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWH56_RS00235	COG1121	(ABC) transporter
AWH56_RS00245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AWH56_RS00250	COG0513	Belongs to the DEAD box helicase family
AWH56_RS00260	COG1329	Transcriptional regulator
AWH56_RS00265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AWH56_RS00270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWH56_RS00275	COG2384	SAM-dependent methyltransferase
AWH56_RS00290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWH56_RS00295	COG0358	DNA primase activity
AWH56_RS00300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWH56_RS00305	COG0517	IMP dehydrogenase activity
AWH56_RS00310	COG1381	Involved in DNA repair and RecF pathway recombination
AWH56_RS00320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWH56_RS00325	COG0295	cytidine deaminase activity
AWH56_RS00335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AWH56_RS00340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWH56_RS00345	COG1480	7TM receptor with intracellular HD hydrolase
AWH56_RS00350	COG1702	phosphate starvation-inducible protein PhoH
AWH56_RS00370	COG4864	UPF0365 protein
AWH56_RS00375	COG1030	water channel activity
AWH56_RS00380	COG1610	YqeY-like protein
AWH56_RS00385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWH56_RS00390	COG1283	sodium-dependent phosphate transmembrane transporter activity
AWH56_RS00395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AWH56_RS00400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWH56_RS00405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AWH56_RS00410	COG2264	protein methyltransferase activity
AWH56_RS00415	COG0484	heat shock protein binding
AWH56_RS00420	COG0443	Heat shock 70 kDa protein
AWH56_RS00425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWH56_RS00430	COG1420	regulation of RNA biosynthetic process
AWH56_RS00435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWH56_RS00440	COG0481	GTPase activity
AWH56_RS00450	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWH56_RS00460	COG0268	Binds directly to 16S ribosomal RNA
AWH56_RS00465	COG1466	dna polymerase III delta subunit
AWH56_RS00475	COG0658	competence protein
AWH56_RS00475	COG2333	competence protein COMEC
AWH56_RS00480	COG2131	deaminase
AWH56_RS00490	COG1555	photosystem II stabilization
AWH56_RS00490	COG1596	polysaccharide export
AWH56_RS00500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWH56_RS00505	COG2226	methyltransferase
AWH56_RS00510	COG2996	Protein conserved in bacteria
AWH56_RS00515	COG0799	negative regulation of ribosome biogenesis
AWH56_RS00520	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWH56_RS00525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWH56_RS00530	COG1534	Rna-binding protein
AWH56_RS00535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWH56_RS00540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWH56_RS00555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWH56_RS00555	COG2111	Na H antiporter
AWH56_RS00560	COG2111	Na H antiporter
AWH56_RS00565	COG1006	Multisubunit Na H antiporter MnhC subunit
AWH56_RS00570	COG0651	ATP synthesis coupled electron transport
AWH56_RS00575	COG1863	multisubunit Na H antiporter MnhE subunit
AWH56_RS00580	COG2212	antiporter activity
AWH56_RS00585	COG1320	monovalent cation:proton antiporter activity
AWH56_RS00595	COG0247	lactate metabolic process
AWH56_RS00600	COG0277	FAD linked oxidase domain protein
AWH56_RS00605	COG3835	regulator
AWH56_RS00610	COG0688	phosphatidylethanolamine metabolic process
AWH56_RS00615	COG1183	phosphatidylcholine synthase activity
AWH56_RS00625	COG0617	tRNA 3'-terminal CCA addition
AWH56_RS00625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWH56_RS00625	COG3620	sequence-specific DNA binding
AWH56_RS00640	COG0655	NAD(P)H dehydrogenase (quinone) activity
AWH56_RS00645	COG1846	Transcriptional regulator
AWH56_RS00710	COG1309	transcriptional regulator
AWH56_RS00715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWH56_RS00720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWH56_RS00725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AWH56_RS00730	COG1024	Enoyl-CoA hydratase
AWH56_RS00735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWH56_RS00740	COG0511	ligase activity, forming carbon-carbon bonds
AWH56_RS00745	COG0439	Biotin carboxylase
AWH56_RS00750	COG1960	acyl-CoA dehydrogenase activity
AWH56_RS00780	COG2239	Acts as a magnesium transporter
AWH56_RS00790	COG0366	Alpha amylase catalytic
AWH56_RS00795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWH56_RS00805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AWH56_RS00820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWH56_RS00830	COG0768	penicillin binding
AWH56_RS00835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWH56_RS00840	COG0572	uridine kinase
AWH56_RS00845	COG0826	peptidase U32
AWH56_RS00850	COG0826	peptidase U32
AWH56_RS00860	COG4122	O-methyltransferase activity
AWH56_RS00865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWH56_RS00870	COG3906	Belongs to the UPF0473 family
AWH56_RS00880	COG4472	Bacterial protein of unknown function (DUF965)
AWH56_RS00885	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWH56_RS00890	COG0628	permease
AWH56_RS00910	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWH56_RS00920	COG0482	sulfurtransferase activity
AWH56_RS00925	COG1104	cysteine desulfurase activity
AWH56_RS00930	COG1959	2 iron, 2 sulfur cluster binding
AWH56_RS00935	COG2364	Membrane
AWH56_RS00940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWH56_RS00950	COG1556	Lactate utilization protein
AWH56_RS00955	COG1139	Iron-sulfur cluster binding protein
AWH56_RS00960	COG0247	lactate metabolic process
AWH56_RS00965	COG1620	l-lactate permease
AWH56_RS00970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AWH56_RS00980	COG0460	homoserine dehydrogenase
AWH56_RS00985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWH56_RS00990	COG0124	histidyl-tRNA synthetase
AWH56_RS01010	COG1490	D-aminoacyl-tRNA deacylase activity
AWH56_RS01015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWH56_RS01020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWH56_RS01025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWH56_RS01025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWH56_RS01030	COG5416	Lipopolysaccharide assembly protein A domain
AWH56_RS01035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWH56_RS01040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWH56_RS01040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWH56_RS01045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWH56_RS01045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWH56_RS01060	COG2244	polysaccharide biosynthetic process
AWH56_RS01070	COG2323	membrane
AWH56_RS01085	COG1862	Preprotein translocase
AWH56_RS01090	COG0343	queuine tRNA-ribosyltransferase activity
AWH56_RS01105	COG2255	four-way junction helicase activity
AWH56_RS01110	COG0632	four-way junction helicase activity
AWH56_RS01125	COG1388	LysM domain
AWH56_RS01135	COG0157	Belongs to the NadC ModD family
AWH56_RS01140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AWH56_RS01145	COG1104	cysteine desulfurase activity
AWH56_RS01150	COG1827	regulation of RNA biosynthetic process
AWH56_RS01155	COG0077	Prephenate dehydratase
AWH56_RS01160	COG4492	Belongs to the UPF0735 family
AWH56_RS01165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AWH56_RS01170	COG3290	protein histidine kinase activity
AWH56_RS01175	COG1116	anion transmembrane transporter activity
AWH56_RS01190	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AWH56_RS01195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AWH56_RS01200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AWH56_RS01205	COG0697	spore germination
AWH56_RS01225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_RS01230	COG0785	Cytochrome C biogenesis protein
AWH56_RS01235	COG1473	amidohydrolase
AWH56_RS01250	COG4473	ABC transporter
AWH56_RS01255	COG1131	(ABC) transporter
AWH56_RS01260	COG0318	PFAM AMP-dependent synthetase and ligase
AWH56_RS01265	COG0537	adenosine 5'-monophosphoramidase activity
AWH56_RS01270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AWH56_RS01285	COG1846	Transcriptional regulator
AWH56_RS01310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AWH56_RS01325	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWH56_RS01330	COG2205	protein histidine kinase activity
AWH56_RS01330	COG2770	Histidine kinase
AWH56_RS01335	COG0745	RESPONSE REGULATOR receiver
AWH56_RS01355	COG0420	3'-5' exonuclease activity
AWH56_RS01370	COG0561	phosphatase activity
AWH56_RS01375	COG3679	Belongs to the UPF0342 family
AWH56_RS01380	COG4399	Belongs to the UPF0754 family
AWH56_RS01385	COG0189	ligase activity
AWH56_RS01390	COG0189	ligase activity
AWH56_RS01395	COG0189	ligase activity
AWH56_RS01400	COG0189	ligase activity
AWH56_RS01420	COG2508	Transcriptional regulator
AWH56_RS01425	COG3842	ATPase activity
AWH56_RS01440	COG0840	transmembrane signaling receptor activity
AWH56_RS01445	COG0840	transmembrane signaling receptor activity
AWH56_RS01465	COG1741	Belongs to the pirin family
AWH56_RS01470	COG0702	epimerase
AWH56_RS01475	COG1132	(ABC) transporter
AWH56_RS01480	COG1132	(ABC) transporter
AWH56_RS01485	COG3764	Sortase (surface protein transpeptidase)
AWH56_RS01500	COG0517	IMP dehydrogenase activity
AWH56_RS01500	COG0617	tRNA 3'-terminal CCA addition
AWH56_RS01500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWH56_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS01545	COG3706	GGDEF domain
AWH56_RS01575	COG0783	Belongs to the Dps family
AWH56_RS01595	COG1834	amidinotransferase
AWH56_RS01600	COG1278	Cold shock
AWH56_RS01610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AWH56_RS01615	COG0697	spore germination
AWH56_RS01640	COG1396	sequence-specific DNA binding
AWH56_RS01680	COG1131	(ABC) transporter
AWH56_RS01685	COG0697	spore germination
AWH56_RS01705	COG1187	pseudouridine synthase activity
AWH56_RS01725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWH56_RS01745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWH56_RS01755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWH56_RS01755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWH56_RS01755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWH56_RS01760	COG1105	Belongs to the carbohydrate kinase PfkB family
AWH56_RS01765	COG1349	DNA-binding transcription factor activity
AWH56_RS01770	COG0586	Pfam SNARE associated Golgi protein
AWH56_RS01775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWH56_RS01800	COG4512	PFAM Accessory gene regulator B
AWH56_RS01810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AWH56_RS01820	COG1910	domain protein
AWH56_RS01835	COG0586	Pfam SNARE associated Golgi protein
AWH56_RS01840	COG2112	serine threonine protein kinase
AWH56_RS01855	COG0477	Major facilitator Superfamily
AWH56_RS01860	COG3273	potassium ion transport
AWH56_RS01860	COG0471	metal ion transport
AWH56_RS01875	COG2409	Drug exporters of the RND superfamily
AWH56_RS01890	COG0347	Belongs to the P(II) protein family
AWH56_RS01920	COG1785	Belongs to the alkaline phosphatase family
AWH56_RS01930	COG1968	undecaprenyl-diphosphatase activity
AWH56_RS01935	COG0772	Belongs to the SEDS family
AWH56_RS02065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_RS02150	COG3243	poly(R)-hydroxyalkanoic acid synthase
AWH56_RS02155	COG2124	cytochrome p450
AWH56_RS02170	COG1924	4 iron, 4 sulfur cluster binding
AWH56_RS02210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWH56_RS02215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWH56_RS02225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWH56_RS02230	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AWH56_RS02240	COG3153	acetyltransferase
AWH56_RS02240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWH56_RS02260	COG1079	Belongs to the binding-protein-dependent transport system permease family
AWH56_RS02265	COG4603	Belongs to the binding-protein-dependent transport system permease family
AWH56_RS02270	COG3845	ABC transporter
AWH56_RS02275	COG1744	ABC transporter substrate-binding protein PnrA-like
AWH56_RS02315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWH56_RS02320	COG2201	protein-glutamate methylesterase activity
AWH56_RS02325	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AWH56_RS02330	COG3005	denitrification pathway
AWH56_RS02335	COG4187	Peptidase family M20/M25/M40
AWH56_RS02345	COG5002	protein histidine kinase activity
AWH56_RS02350	COG4251	negative regulation of phosphorylation
AWH56_RS02350	COG2203	Gaf domain
AWH56_RS02350	COG5001	Diguanylate cyclase
AWH56_RS02350	COG3706	GGDEF domain
AWH56_RS02355	COG4608	Belongs to the ABC transporter superfamily
AWH56_RS02360	COG0444	Belongs to the ABC transporter superfamily
AWH56_RS02365	COG0601	transmembrane transport
AWH56_RS02370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_RS02385	COG1858	cytochrome C peroxidase
AWH56_RS02395	COG1937	Protein conserved in bacteria
AWH56_RS02400	COG0425	Belongs to the sulfur carrier protein TusA family
AWH56_RS02405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_RS02405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_RS02410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_RS02410	COG0425	Belongs to the sulfur carrier protein TusA family
AWH56_RS02415	COG2210	Belongs to the sulfur carrier protein TusA family
AWH56_RS02440	COG0437	4 iron, 4 sulfur cluster binding
AWH56_RS02450	COG4191	Histidine kinase
AWH56_RS02465	COG1131	(ABC) transporter
AWH56_RS02475	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AWH56_RS02480	COG0644	oxidoreductase
AWH56_RS02495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AWH56_RS02505	COG1131	(ABC) transporter
AWH56_RS02525	COG4585	Histidine kinase
AWH56_RS02530	COG2197	response regulator
AWH56_RS02545	COG0840	transmembrane signaling receptor activity
AWH56_RS02555	COG1388	LysM domain
AWH56_RS02555	COG3584	3D domain protein
AWH56_RS02565	COG3858	chitin binding
AWH56_RS02635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWH56_RS02640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWH56_RS02655	COG0109	protoheme IX farnesyltransferase activity
AWH56_RS02665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_RS02670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_RS02680	COG2207	Transcriptional regulator
AWH56_RS02680	COG1917	Cupin 2, conserved barrel domain protein
AWH56_RS02685	COG3620	sequence-specific DNA binding
AWH56_RS02695	COG2259	Doxx family
AWH56_RS02700	COG1733	regulation of RNA biosynthetic process
AWH56_RS02705	COG4974	Belongs to the 'phage' integrase family
AWH56_RS02810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_RS02815	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_RS02820	COG2301	Belongs to the HpcH HpaI aldolase family
AWH56_RS02825	COG1063	alcohol dehydrogenase
AWH56_RS02830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_RS02830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_RS02840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_RS02845	COG1929	Belongs to the glycerate kinase type-1 family
AWH56_RS02875	COG4974	Belongs to the 'phage' integrase family
AWH56_RS02880	COG0582	viral genome integration into host DNA
AWH56_RS02885	COG4974	Belongs to the 'phage' integrase family
AWH56_RS02900	COG1074	ATP-dependent DNA helicase activity
AWH56_RS02960	COG1404	Belongs to the peptidase S8 family
AWH56_RS02965	COG2718	Belongs to the UPF0229 family
AWH56_RS02980	COG2766	serine protein kinase
AWH56_RS02985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_RS02995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWH56_RS03005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWH56_RS03025	COG2207	Transcriptional regulator
AWH56_RS03045	COG3852	Histidine kinase
AWH56_RS03055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AWH56_RS03065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AWH56_RS03095	COG1484	DNA-dependent DNA replication
AWH56_RS03115	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AWH56_RS03125	COG2201	protein-glutamate methylesterase activity
AWH56_RS03245	COG0735	belongs to the Fur family
AWH56_RS03250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_RS03255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AWH56_RS03275	COG4555	ABC transporter
AWH56_RS03280	COG1316	TRANSCRIPTIONal
AWH56_RS03285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AWH56_RS03290	COG0070	glutamate synthase
AWH56_RS03290	COG0067	glutamate synthase
AWH56_RS03290	COG0069	glutamate synthase activity
AWH56_RS03295	COG4129	membrane
AWH56_RS03320	COG1132	(ABC) transporter
AWH56_RS03325	COG3557	Belongs to the UPF0374 family
AWH56_RS03345	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS03360	COG0436	Aminotransferase
AWH56_RS03375	COG2059	Chromate
AWH56_RS03380	COG2059	Chromate
AWH56_RS03385	COG0405	Gamma-glutamyltransferase
AWH56_RS03395	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS03400	COG1194	a g-specific adenine glycosylase
AWH56_RS03410	COG1988	membrane-bound metal-dependent
AWH56_RS03435	COG1620	l-lactate permease
AWH56_RS03440	COG2137	regulation of response to DNA damage stimulus
AWH56_RS03445	COG1090	epimerase
AWH56_RS03475	COG4585	Histidine kinase
AWH56_RS03480	COG2197	response regulator
AWH56_RS03490	COG0456	acetyltransferase
AWH56_RS03495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AWH56_RS03500	COG1917	Cupin 2, conserved barrel domain protein
AWH56_RS03520	COG0431	NADPH-dependent FMN reductase
AWH56_RS03540	COG2197	response regulator
AWH56_RS03545	COG4585	Histidine kinase
AWH56_RS03570	COG3033	Beta-eliminating lyase
AWH56_RS03585	COG2358	TRAP transporter, solute receptor (TAXI family
AWH56_RS03595	COG2197	response regulator
AWH56_RS03600	COG4585	Histidine kinase
AWH56_RS03605	COG3239	Fatty acid desaturase
AWH56_RS03665	COG2197	response regulator
AWH56_RS03685	COG1183	phosphatidylcholine synthase activity
AWH56_RS03690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_RS03705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWH56_RS03770	COG4974	Belongs to the 'phage' integrase family
AWH56_RS03785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_RS03795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AWH56_RS03805	COG3621	Patatin-like phospholipase
AWH56_RS03850	COG4372	Transposase
AWH56_RS03875	COG4372	Transposase
AWH56_RS03900	COG2801	Transposase and inactivated derivatives
AWH56_RS03905	COG2801	Transposase and inactivated derivatives
AWH56_RS03910	COG2801	Transposase and inactivated derivatives
AWH56_RS03920	COG1555	photosystem II stabilization
AWH56_RS03920	COG3568	Endonuclease Exonuclease Phosphatase
AWH56_RS03935	COG1320	monovalent cation:proton antiporter activity
AWH56_RS03940	COG2212	antiporter activity
AWH56_RS03945	COG1863	multisubunit Na H antiporter MnhE subunit
AWH56_RS03950	COG0651	ATP synthesis coupled electron transport
AWH56_RS03955	COG1006	Multisubunit Na H antiporter MnhC subunit
AWH56_RS03960	COG2111	Na H antiporter
AWH56_RS03965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWH56_RS03965	COG2111	Na H antiporter
AWH56_RS04010	COG0719	Fe-S assembly protein
AWH56_RS04015	COG0822	iron-sulfur transferase activity
AWH56_RS04020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWH56_RS04025	COG0719	Fe-S assembly protein
AWH56_RS04030	COG0396	ATPase activity
AWH56_RS04045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AWH56_RS04055	COG1464	Belongs to the NlpA lipoprotein family
AWH56_RS04060	COG2011	ABC-type metal ion transport system permease component
AWH56_RS04065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWH56_RS04085	COG0509	glycine decarboxylation via glycine cleavage system
AWH56_RS04090	COG1393	Belongs to the ArsC family
AWH56_RS04100	COG1960	acyl-CoA dehydrogenase activity
AWH56_RS04105	COG0183	Belongs to the thiolase family
AWH56_RS04110	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWH56_RS04110	COG1024	Enoyl-CoA hydratase
AWH56_RS04120	COG5577	PFAM Coat F domain
AWH56_RS04145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWH56_RS04155	COG4447	cellulose binding
AWH56_RS04160	COG1191	sigma factor activity
AWH56_RS04200	COG2205	protein histidine kinase activity
AWH56_RS04205	COG0745	RESPONSE REGULATOR receiver
AWH56_RS04220	COG0745	RESPONSE REGULATOR receiver
AWH56_RS04225	COG2217	Heavy metal translocating P-type atpase
AWH56_RS04230	COG0840	transmembrane signaling receptor activity
AWH56_RS04260	COG2132	Multicopper oxidase
AWH56_RS04270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWH56_RS04300	COG5002	protein histidine kinase activity
AWH56_RS04315	COG0367	asparagine synthase
AWH56_RS04320	COG0791	NLP P60 protein
AWH56_RS04345	COG1393	Belongs to the ArsC family
AWH56_RS04350	COG0398	Pfam SNARE associated Golgi protein
AWH56_RS04360	COG4372	Transposase
AWH56_RS04380	COG3850	Histidine kinase
AWH56_RS04380	COG5002	protein histidine kinase activity
AWH56_RS04385	COG0745	RESPONSE REGULATOR receiver
AWH56_RS04390	COG0367	asparagine synthase
AWH56_RS04395	COG0791	NLP P60 protein
AWH56_RS04395	COG1388	LysM domain
AWH56_RS04410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWH56_RS04415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AWH56_RS04420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AWH56_RS04435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWH56_RS04460	COG2808	Putative FMN-binding domain
AWH56_RS04545	COG4974	Belongs to the 'phage' integrase family
AWH56_RS04590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWH56_RS04610	COG0557	exoribonuclease II activity
AWH56_RS04615	COG1647	Serine aminopeptidase, S33
AWH56_RS04625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AWH56_RS04630	COG0148	phosphopyruvate hydratase activity
AWH56_RS04635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWH56_RS04640	COG0149	triose-phosphate isomerase activity
AWH56_RS04645	COG0126	phosphoglycerate kinase activity
AWH56_RS04650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AWH56_RS04665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AWH56_RS04670	COG0740	serine-type endopeptidase activity
AWH56_RS04675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWH56_RS04680	COG1481	regulation of sporulation
AWH56_RS04685	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AWH56_RS04690	COG1660	Displays ATPase and GTPase activities
AWH56_RS04695	COG1051	belongs to the nudix hydrolase family
AWH56_RS04700	COG0492	ferredoxin-NADP+ reductase activity
AWH56_RS04705	COG0457	Tetratricopeptide repeat
AWH56_RS04710	COG0140	phosphoribosyl-ATP diphosphatase activity
AWH56_RS04710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AWH56_RS04715	COG0107	imidazoleglycerol-phosphate synthase activity
AWH56_RS04720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AWH56_RS04725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AWH56_RS04730	COG0131	Imidazoleglycerol-phosphate dehydratase
AWH56_RS04735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AWH56_RS04740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AWH56_RS04745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AWH56_RS04760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AWH56_RS04765	COG0110	maltose O-acetyltransferase activity
AWH56_RS04775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AWH56_RS04785	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWH56_RS04790	COG1950	PFAM Membrane protein of
AWH56_RS04795	COG1983	PspC domain protein
AWH56_RS04800	COG3595	metallopeptidase activity
AWH56_RS04805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWH56_RS04810	COG0556	nucleotide-excision repair
AWH56_RS04815	COG2223	nitrite transmembrane transporter activity
AWH56_RS04840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWH56_RS04845	COG0793	Belongs to the peptidase S41A family
AWH56_RS04845	COG3409	Peptidoglycan-binding domain 1 protein
AWH56_RS04850	COG0739	heme binding
AWH56_RS04855	COG2177	Part of the ABC transporter FtsEX involved in
AWH56_RS04860	COG2884	Cell division ATP-binding protein ftsE
AWH56_RS04880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_RS04890	COG0653	protein targeting
AWH56_RS04895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AWH56_RS04900	COG1278	Cold shock
AWH56_RS04905	COG0367	asparagine synthase
AWH56_RS04910	COG4990	cell redox homeostasis
AWH56_RS04920	COG0629	single-stranded DNA binding
AWH56_RS04950	COG0606	chelatase, subunit chli
AWH56_RS04955	COG0758	DNA mediated transformation
AWH56_RS04975	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AWH56_RS04990	COG1361	Conserved repeat domain
AWH56_RS04990	COG2911	Protein conserved in bacteria
AWH56_RS04990	COG3266	domain, Protein
AWH56_RS05005	COG1516	flagellar protein fliS
AWH56_RS05010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AWH56_RS05015	COG1334	flagellar protein FlaG
AWH56_RS05020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AWH56_RS05025	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AWH56_RS05030	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AWH56_RS05045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AWH56_RS05050	COG4786	Flagellar basal body rod
AWH56_RS05050	COG1256	bacterial-type flagellum assembly
AWH56_RS05075	COG1040	competence protein
AWH56_RS05080	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AWH56_RS05125	COG3266	domain, Protein
AWH56_RS05125	COG1361	Conserved repeat domain
AWH56_RS05125	COG2911	Protein conserved in bacteria
AWH56_RS05135	COG4824	toxin secretion phage lysis holin
AWH56_RS05145	COG4974	Belongs to the 'phage' integrase family
AWH56_RS05240	COG0740	serine-type endopeptidase activity
AWH56_RS05255	COG1802	Transcriptional regulator
AWH56_RS05255	COG4626	Terminase
AWH56_RS05350	COG1061	Type III restriction enzyme res subunit
AWH56_RS05440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_RS05450	COG1307	EDD domain protein, DegV family
AWH56_RS05475	COG1739	Uncharacterized protein family UPF0029
AWH56_RS05480	COG1316	TRANSCRIPTIONal
AWH56_RS05485	COG0653	protein targeting
AWH56_RS05500	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWH56_RS05535	COG1376	ErfK ybiS ycfS ynhG family protein
AWH56_RS05555	COG0728	peptidoglycan biosynthetic process
AWH56_RS05565	COG1361	Conserved repeat domain
AWH56_RS05590	COG0028	Belongs to the TPP enzyme family
AWH56_RS05595	COG3852	Histidine kinase
AWH56_RS05655	COG0737	Belongs to the 5'-nucleotidase family
AWH56_RS05665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AWH56_RS05670	COG0363	glucosamine-6-phosphate deaminase activity
AWH56_RS05675	COG1940	carbohydrate kinase activity
AWH56_RS05685	COG1472	Belongs to the glycosyl hydrolase 3 family
AWH56_RS05700	COG1653	transport
AWH56_RS05705	COG0395	ABC-type sugar transport system, permease component
AWH56_RS05710	COG4209	transmembrane transport
AWH56_RS05720	COG1737	Transcriptional regulator
AWH56_RS05725	COG3458	cephalosporin-C deacetylase activity
AWH56_RS05730	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AWH56_RS05735	COG5578	integral membrane protein
AWH56_RS05785	COG1744	ABC transporter substrate-binding protein PnrA-like
AWH56_RS05790	COG0840	transmembrane signaling receptor activity
AWH56_RS05825	COG4974	Belongs to the 'phage' integrase family
AWH56_RS05870	COG0596	Alpha beta hydrolase
AWH56_RS06025	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWH56_RS06040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWH56_RS06045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AWH56_RS06055	COG0438	transferase activity, transferring glycosyl groups
AWH56_RS06060	COG0728	peptidoglycan biosynthetic process
AWH56_RS06090	COG4193	domain, Protein
AWH56_RS06090	COG5263	repeat protein
AWH56_RS06100	COG0791	NLP P60 protein
AWH56_RS06105	COG1404	Belongs to the peptidase S8 family
AWH56_RS06115	COG0791	NLP P60 protein
AWH56_RS06115	COG1388	LysM domain
AWH56_RS06120	COG3300	MHYT domain
AWH56_RS06120	COG5001	Diguanylate cyclase
AWH56_RS06140	COG4786	Flagellar basal body rod
AWH56_RS06145	COG4786	Flagellar basal body rod
AWH56_RS06155	COG1609	Transcriptional regulator
AWH56_RS06170	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AWH56_RS06175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AWH56_RS06190	COG0739	heme binding
AWH56_RS06195	COG2385	sporulation resulting in formation of a cellular spore
AWH56_RS06200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWH56_RS06210	COG4836	Membrane
AWH56_RS06215	COG1007	ATP synthesis coupled electron transport
AWH56_RS06225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWH56_RS06235	COG0839	Belongs to the complex I subunit 6 family
AWH56_RS06245	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AWH56_RS06250	COG0649	NAD binding
AWH56_RS06255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWH56_RS06260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWH56_RS06265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWH56_RS06270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AWH56_RS06275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AWH56_RS06280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AWH56_RS06285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AWH56_RS06290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWH56_RS06295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AWH56_RS06305	COG0356	it plays a direct role in the translocation of protons across the membrane
AWH56_RS06320	COG1404	Belongs to the peptidase S8 family
AWH56_RS06330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AWH56_RS06335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AWH56_RS06340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AWH56_RS06350	COG0698	ribose 5-phosphate isomerase
AWH56_RS06355	COG0840	transmembrane signaling receptor activity
AWH56_RS06370	COG0009	L-threonylcarbamoyladenylate synthase
AWH56_RS06390	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWH56_RS06400	COG1435	thymidine kinase activity
AWH56_RS06405	COG0254	rRNA binding
AWH56_RS06410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWH56_RS06415	COG1494	fructose-1,6-bisphosphatase
AWH56_RS06420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWH56_RS06425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWH56_RS06430	COG0191	fructose-bisphosphate aldolase activity
AWH56_RS06435	COG2204	response regulator
AWH56_RS06440	COG0504	CTP synthase activity
AWH56_RS06445	COG3343	RNA polymerase activity
AWH56_RS06450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_RS06450	COG1703	isobutyryl-CoA mutase activity
AWH56_RS06450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_RS06455	COG1309	transcriptional regulator
AWH56_RS06460	COG1960	acyl-CoA dehydrogenase activity
AWH56_RS06465	COG1960	acyl-CoA dehydrogenase activity
AWH56_RS06470	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWH56_RS06475	COG0183	Belongs to the thiolase family
AWH56_RS06480	COG0247	lactate metabolic process
AWH56_RS06480	COG2181	nitrate reductase activity
AWH56_RS06490	COG2217	Heavy metal translocating P-type atpase
AWH56_RS06495	COG0596	Alpha beta hydrolase
AWH56_RS06505	COG0018	arginyl-trna synthetase
AWH56_RS06515	COG0010	Belongs to the arginase family
AWH56_RS06520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AWH56_RS06525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_RS06545	COG3465	dGTPase activity
AWH56_RS06550	COG1078	dGTPase activity
AWH56_RS06555	COG4844	belongs to the
AWH56_RS06565	COG0280	phosphate acetyltransferase
AWH56_RS06570	COG1309	transcriptional regulator
AWH56_RS06575	COG1902	pentaerythritol trinitrate reductase activity
AWH56_RS06575	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWH56_RS06580	COG1024	Enoyl-CoA hydratase
AWH56_RS06585	COG3253	May function as heme-dependent peroxidase
AWH56_RS06590	COG3773	Cell wall hydrolase
AWH56_RS06600	COG2363	Small membrane protein
AWH56_RS06615	COG5002	protein histidine kinase activity
AWH56_RS06625	COG2084	Dehydrogenase
AWH56_RS06630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWH56_RS06635	COG0494	nUDIX hydrolase
AWH56_RS06645	COG0423	glycine-tRNA ligase activity
AWH56_RS06655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWH56_RS06660	COG0513	Belongs to the DEAD box helicase family
AWH56_RS06665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AWH56_RS06670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWH56_RS06675	COG0011	TIGRFAM Protein of
AWH56_RS06695	COG3706	GGDEF domain
AWH56_RS06700	COG0322	excinuclease ABC activity
AWH56_RS06735	COG0745	RESPONSE REGULATOR receiver
AWH56_RS06785	COG4974	Belongs to the 'phage' integrase family
AWH56_RS06825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWH56_RS06835	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AWH56_RS06875	COG2003	Belongs to the UPF0758 family
AWH56_RS06900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_RS06905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWH56_RS06915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWH56_RS06920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWH56_RS06925	COG4853	Protein conserved in bacteria
AWH56_RS06930	COG4863	YycH protein
AWH56_RS06935	COG5002	protein histidine kinase activity
AWH56_RS06940	COG0745	RESPONSE REGULATOR receiver
AWH56_RS06945	COG1388	LysM domain
AWH56_RS06945	COG4942	peptidase
AWH56_RS06980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AWH56_RS06985	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AWH56_RS06995	COG0720	synthase
AWH56_RS07000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AWH56_RS07005	COG0305	Participates in initiation and elongation during chromosome replication
AWH56_RS07010	COG0359	binds to the 23S rRNA
AWH56_RS07015	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AWH56_RS07020	COG4241	membrane
AWH56_RS07025	COG0569	domain protein
AWH56_RS07030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AWH56_RS07035	COG0629	single-stranded DNA binding
AWH56_RS07040	COG0360	Binds together with S18 to 16S ribosomal RNA
AWH56_RS07045	COG0012	GTP binding
AWH56_RS07050	COG0243	molybdopterin cofactor binding
AWH56_RS07055	COG4481	Protein conserved in bacteria
AWH56_RS07060	COG3949	Membrane
AWH56_RS07075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWH56_RS07080	COG1475	DNA binding
AWH56_RS07085	COG1192	Involved in chromosome partitioning
AWH56_RS07090	COG1475	DNA binding
AWH56_RS07095	COG0357	Ribosomal RNA small subunit methyltransferase G
AWH56_RS07100	COG0445	tRNA wobble uridine modification
AWH56_RS07105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWH56_RS07110	COG1847	R3H domain protein
AWH56_RS07115	COG0706	membrane insertase activity
AWH56_RS07120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWH56_RS07130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AWH56_RS07135	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AWH56_RS07140	COG0592	DNA-directed DNA polymerase activity
AWH56_RS07145	COG2501	S4 domain
AWH56_RS07160	COG0187	DNA topoisomerase II activity
AWH56_RS07165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWH56_RS07170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWH56_RS07200	COG0516	GMP reductase activity
AWH56_RS07200	COG0517	IMP dehydrogenase activity
AWH56_RS07210	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AWH56_RS07215	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AWH56_RS07220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWH56_RS07225	COG0601	transmembrane transport
AWH56_RS07230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_RS07235	COG0444	Belongs to the ABC transporter superfamily
AWH56_RS07240	COG4608	Belongs to the ABC transporter superfamily
AWH56_RS07250	COG0601	transmembrane transport
AWH56_RS07255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_RS07260	COG0444	Belongs to the ABC transporter superfamily
AWH56_RS07265	COG4608	Belongs to the ABC transporter superfamily
AWH56_RS07275	COG0601	transmembrane transport
AWH56_RS07280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_RS07285	COG0444	Belongs to the ABC transporter superfamily
AWH56_RS07290	COG4608	Belongs to the ABC transporter superfamily
AWH56_RS07300	COG0601	transmembrane transport
AWH56_RS07305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_RS07315	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AWH56_RS07325	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AWH56_RS07340	COG1138	Cytochrome C-type biogenesis protein
AWH56_RS07360	COG4555	ABC transporter
AWH56_RS07370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWH56_RS07380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS07390	COG0590	tRNA wobble adenosine to inosine editing
AWH56_RS07400	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWH56_RS07405	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWH56_RS07410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWH56_RS07455	COG1982	Orn Lys Arg decarboxylase major
AWH56_RS07460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AWH56_RS07465	COG3870	Protein conserved in bacteria
AWH56_RS07470	COG0470	DNA polymerase III
AWH56_RS07475	COG1774	PSP1 C-terminal conserved region
AWH56_RS07480	COG4467	Involved in initiation control of chromosome replication
AWH56_RS07485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWH56_RS07490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWH56_RS07495	COG2002	toxin-antitoxin pair type II binding
AWH56_RS07500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWH56_RS07500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWH56_RS07505	COG0084	hydrolase, TatD family'
AWH56_RS07510	COG3583	domain protein
AWH56_RS07510	COG3584	3D domain protein
AWH56_RS07520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWH56_RS07530	COG4466	Protein conserved in bacteria
AWH56_RS07540	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWH56_RS07545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWH56_RS07550	COG0251	oxidation-reduction process
AWH56_RS07555	COG2088	sporulation resulting in formation of a cellular spore
AWH56_RS07560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWH56_RS07565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWH56_RS07570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AWH56_RS07575	COG0193	aminoacyl-tRNA hydrolase activity
AWH56_RS07585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWH56_RS07590	COG2002	toxin-antitoxin pair type II binding
AWH56_RS07600	COG2244	polysaccharide biosynthetic process
AWH56_RS07605	COG3956	TIGRFAM MazG family protein
AWH56_RS07610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWH56_RS07625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AWH56_RS07630	COG1098	S1 RNA binding domain
AWH56_RS07635	COG2208	phosphoserine phosphatase activity
AWH56_RS07640	COG2304	oxidoreductase activity
AWH56_RS07645	COG0515	serine threonine protein kinase
AWH56_RS07650	COG2966	Psort location CytoplasmicMembrane, score
AWH56_RS07660	COG0037	tRNA processing
AWH56_RS07665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AWH56_RS07670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWH56_RS07675	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AWH56_RS07680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWH56_RS07685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWH56_RS07690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AWH56_RS07695	COG0512	Glutamine amidotransferase of anthranilate synthase
AWH56_RS07700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWH56_RS07705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AWH56_RS07710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AWH56_RS07715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AWH56_RS07720	COG1396	sequence-specific DNA binding
AWH56_RS07725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWH56_RS07730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWH56_RS07835	COG1285	pathogenesis
AWH56_RS07845	COG3880	PFAM UvrB UvrC protein
AWH56_RS07850	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AWH56_RS07855	COG0542	response to heat
AWH56_RS07860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWH56_RS07865	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AWH56_RS07870	COG4956	integral membrane protein (PIN domain superfamily)
AWH56_RS07875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AWH56_RS07880	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AWH56_RS07885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWH56_RS07890	COG1045	serine acetyltransferase
AWH56_RS07895	COG0215	cysteine-tRNA ligase activity
AWH56_RS07905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWH56_RS07910	COG3688	RNA-binding protein containing a PIN domain
AWH56_RS07920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWH56_RS07925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AWH56_RS07930	COG0250	Participates in transcription elongation, termination and antitermination
AWH56_RS07940	COG0081	regulation of translation
AWH56_RS07945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AWH56_RS07950	COG0222	ribosome binding
AWH56_RS07955	COG2813	Specifically methylates the guanine in position
AWH56_RS07960	COG0085	RNA polymerase activity
AWH56_RS07965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWH56_RS07970	COG1358	cellular component organization or biogenesis
AWH56_RS07975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWH56_RS07980	COG0049	tRNA binding
AWH56_RS07985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWH56_RS07990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWH56_RS08005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWH56_RS08010	COG0088	Forms part of the polypeptide exit tunnel
AWH56_RS08015	COG0089	rRNA binding
AWH56_RS08020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWH56_RS08025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AWH56_RS08030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWH56_RS08035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWH56_RS08040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWH56_RS08045	COG0255	Belongs to the universal ribosomal protein uL29 family
AWH56_RS08050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWH56_RS08055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWH56_RS08060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWH56_RS08065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AWH56_RS08070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWH56_RS08075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWH56_RS08080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AWH56_RS08085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWH56_RS08090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWH56_RS08095	COG1841	ribosomal large subunit assembly
AWH56_RS08100	COG0200	Binds to the 23S rRNA
AWH56_RS08105	COG0201	protein transport
AWH56_RS08110	COG0563	adenylate kinase activity
AWH56_RS08115	COG0024	Methionine aminopeptidase
AWH56_RS08120	COG2163	COG2163 Ribosomal protein L14E L6E L27E
AWH56_RS08125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AWH56_RS08130	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AWH56_RS08140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AWH56_RS08145	COG0202	RNA polymerase activity
AWH56_RS08150	COG0203	ribosomal protein L17
AWH56_RS08155	COG1122	ATPase activity
AWH56_RS08160	COG1122	ATPase activity
AWH56_RS08165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AWH56_RS08175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWH56_RS08180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWH56_RS08185	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AWH56_RS08190	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AWH56_RS08210	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWH56_RS08215	COG0489	protein tyrosine kinase activity
AWH56_RS08225	COG2194	sulfuric ester hydrolase activity
AWH56_RS08235	COG0726	polysaccharide deacetylase
AWH56_RS08330	COG1595	DNA-templated transcription, initiation
AWH56_RS08335	COG5662	AntiSigma factor
AWH56_RS08340	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AWH56_RS08345	COG4856	YbbR-like protein
AWH56_RS08350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWH56_RS08355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWH56_RS08405	COG4974	Belongs to the 'phage' integrase family
AWH56_RS08410	COG0582	viral genome integration into host DNA
AWH56_RS08415	COG4974	Belongs to the 'phage' integrase family
AWH56_RS08465	COG1266	CAAX protease self-immunity
AWH56_RS08480	COG1484	DNA-dependent DNA replication
AWH56_RS08660	COG2337	Toxic component of a toxin-antitoxin (TA) module
AWH56_RS08715	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWH56_RS08725	COG0551	DNA topoisomerase type I activity
AWH56_RS08725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWH56_RS08750	COG0539	negative regulation of cytoplasmic translation
AWH56_RS08790	COG0629	single-stranded DNA binding
AWH56_RS08810	COG2003	Belongs to the UPF0758 family
AWH56_RS09005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWH56_RS09085	COG4372	Transposase
AWH56_RS09210	COG3546	catalase activity
AWH56_RS09215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AWH56_RS09225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AWH56_RS09235	COG0437	4 iron, 4 sulfur cluster binding
AWH56_RS09240	COG3301	Polysulphide reductase, NrfD
AWH56_RS09250	COG3842	ATPase activity
AWH56_RS09255	COG4149	molybdate abc transporter
AWH56_RS09260	COG0745	RESPONSE REGULATOR receiver
AWH56_RS09265	COG5002	protein histidine kinase activity
AWH56_RS09300	COG1510	regulation of RNA biosynthetic process
AWH56_RS09305	COG1595	DNA-templated transcription, initiation
AWH56_RS09315	COG0840	transmembrane signaling receptor activity
AWH56_RS09320	COG1988	membrane-bound metal-dependent
AWH56_RS09325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_RS09330	COG3829	transcription factor binding
AWH56_RS09335	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_RS09340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWH56_RS09345	COG0506	proline dehydrogenase activity
AWH56_RS09355	COG2239	Acts as a magnesium transporter
AWH56_RS09365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_RS09370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWH56_RS09375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWH56_RS09385	COG1937	Protein conserved in bacteria
AWH56_RS09390	COG0697	spore germination
AWH56_RS09410	COG3842	ATPase activity
AWH56_RS09415	COG1840	ABC-type Fe3 transport system, periplasmic component
AWH56_RS09420	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWH56_RS09425	COG0705	Rhomboid family
AWH56_RS09430	COG0736	holo-[acyl-carrier-protein] synthase activity
AWH56_RS09435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWH56_RS09435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AWH56_RS09440	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AWH56_RS09450	COG0864	Transcriptional regulator
AWH56_RS09455	COG2337	Toxic component of a toxin-antitoxin (TA) module
AWH56_RS09460	COG1366	Belongs to the anti-sigma-factor antagonist family
AWH56_RS09465	COG1366	Belongs to the anti-sigma-factor antagonist family
AWH56_RS09470	COG2172	sigma factor antagonist activity
AWH56_RS09475	COG2208	phosphoserine phosphatase activity
AWH56_RS09485	COG2172	sigma factor antagonist activity
AWH56_RS09490	COG1191	sigma factor activity
AWH56_RS09500	COG2183	response to ionizing radiation
AWH56_RS09510	COG3091	SprT-like family
AWH56_RS09655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AWH56_RS09660	COG0802	atpase or kinase
AWH56_RS09665	COG1214	PFAM Peptidase M22, glycoprotease
AWH56_RS09670	COG0456	acetyltransferase
AWH56_RS09685	COG0488	(ABC) transporter
AWH56_RS09695	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AWH56_RS09700	COG2814	Major facilitator Superfamily
AWH56_RS09705	COG2022	thiamine diphosphate biosynthetic process
AWH56_RS09720	COG1266	CAAX protease self-immunity
AWH56_RS09725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AWH56_RS09730	COG0459	protein refolding
AWH56_RS09735	COG5577	PFAM Coat F domain
AWH56_RS09740	COG0714	Associated with various cellular activities
AWH56_RS09745	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AWH56_RS09750	COG1305	Transglutaminase-like
AWH56_RS09755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AWH56_RS09755	COG0519	Catalyzes the synthesis of GMP from XMP
AWH56_RS09760	COG2252	PERMEase
AWH56_RS09800	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWH56_RS09810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWH56_RS09815	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AWH56_RS09820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWH56_RS09825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWH56_RS09830	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWH56_RS09835	COG0047	phosphoribosylformylglycinamidine synthase activity
AWH56_RS09840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWH56_RS09845	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AWH56_RS09850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWH56_RS09855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWH56_RS09860	COG0138	bifunctional purine biosynthesis protein purh
AWH56_RS09865	COG0151	Belongs to the GarS family
AWH56_RS09875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AWH56_RS09880	COG1470	cell adhesion involved in biofilm formation
AWH56_RS09885	COG4496	protein, YerC YecD
AWH56_RS09905	COG0010	Belongs to the arginase family
AWH56_RS09910	COG1122	ATPase activity
AWH56_RS09945	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AWH56_RS09950	COG0210	DNA helicase
AWH56_RS09955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWH56_RS09965	COG4851	CamS sex pheromone cAM373 precursor
AWH56_RS09975	COG1842	Phage shock protein A
AWH56_RS09980	COG1585	Membrane protein implicated in regulation of membrane protease activity
AWH56_RS09985	COG2268	Band 7 protein
AWH56_RS09995	COG0406	alpha-ribazole phosphatase activity
AWH56_RS10000	COG4129	membrane
AWH56_RS10005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWH56_RS10010	COG0154	amidase activity
AWH56_RS10015	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWH56_RS10020	COG1597	lipid kinase activity
AWH56_RS10030	COG1595	DNA-templated transcription, initiation
AWH56_RS10050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWH56_RS10070	COG0745	RESPONSE REGULATOR receiver
AWH56_RS10075	COG3850	Histidine kinase
AWH56_RS10075	COG5002	protein histidine kinase activity
AWH56_RS10100	COG2340	Cysteine-rich secretory protein family
AWH56_RS10105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AWH56_RS10130	COG2986	histidine ammonia-lyase
AWH56_RS10135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AWH56_RS10140	COG1228	amidohydrolase
AWH56_RS10145	COG0010	Belongs to the arginase family
AWH56_RS10160	COG3706	GGDEF domain
AWH56_RS10175	COG4443	Transcriptional Coactivator p15 (PC4)
AWH56_RS10200	COG0411	ABC transporter
AWH56_RS10215	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWH56_RS10225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_RS10235	COG2267	carboxylic ester hydrolase activity
AWH56_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS10245	COG0318	PFAM AMP-dependent synthetase and ligase
AWH56_RS10250	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AWH56_RS10255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWH56_RS10290	COG1346	cytolysis
AWH56_RS10335	COG0488	(ABC) transporter
AWH56_RS10345	COG0523	cobalamin synthesis protein
AWH56_RS10355	COG0840	transmembrane signaling receptor activity
AWH56_RS10370	COG1454	alcohol dehydrogenase
AWH56_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_RS10375	COG0567	Dehydrogenase, E1 component
AWH56_RS10380	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWH56_RS10390	COG1595	DNA-templated transcription, initiation
AWH56_RS10425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_RS10435	COG0189	ligase activity
AWH56_RS10445	COG1278	Cold shock
AWH56_RS10450	COG0477	Major facilitator Superfamily
AWH56_RS10460	COG3871	stress protein (general stress protein 26)
AWH56_RS10465	COG2323	membrane
AWH56_RS10470	COG2364	Membrane
AWH56_RS10480	COG0535	radical SAM domain protein
AWH56_RS10510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AWH56_RS10515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWH56_RS10520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_RS10555	COG1253	flavin adenine dinucleotide binding
AWH56_RS10565	COG4536	flavin adenine dinucleotide binding
AWH56_RS10575	COG2112	serine threonine protein kinase
AWH56_RS10595	COG0668	transmembrane transport
AWH56_RS10610	COG0582	viral genome integration into host DNA
AWH56_RS10615	COG3263	regulation of cellular component size
AWH56_RS10625	COG2111	Na H antiporter
AWH56_RS10625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWH56_RS10735	COG1361	Conserved repeat domain
AWH56_RS10735	COG3266	domain, Protein
AWH56_RS10735	COG2911	Protein conserved in bacteria
AWH56_RS10830	COG0730	response to heat
AWH56_RS10835	COG0737	Belongs to the 5'-nucleotidase family
AWH56_RS10840	COG3377	Domain of unknown function (DUF1805)
AWH56_RS10850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AWH56_RS10855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AWH56_RS10865	COG1757	Na H antiporter
AWH56_RS10870	COG0733	neurotransmitter:sodium symporter activity
AWH56_RS10880	COG0739	heme binding
AWH56_RS10885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AWH56_RS10895	COG4470	Protein conserved in bacteria
AWH56_RS10910	COG1494	fructose-1,6-bisphosphatase
AWH56_RS10915	COG2445	Protein of unknown function DUF86
AWH56_RS10925	COG0647	UMP catabolic process
AWH56_RS10930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AWH56_RS10935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AWH56_RS10940	COG4191	Histidine kinase
AWH56_RS10945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_RS10955	COG0460	homoserine dehydrogenase
AWH56_RS10960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AWH56_RS10965	COG0083	homoserine kinase activity
AWH56_RS10970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AWH56_RS10975	COG4837	Protein of unknown function (DUF1462)
AWH56_RS10980	COG1252	NADH dehydrogenase
AWH56_RS10990	COG4844	belongs to the
AWH56_RS11000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AWH56_RS11005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AWH56_RS11015	COG0316	Belongs to the HesB IscA family
AWH56_RS11020	COG0492	ferredoxin-NADP+ reductase activity
AWH56_RS11025	COG1252	NADH dehydrogenase
AWH56_RS11045	COG3584	3D domain protein
AWH56_RS11050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWH56_RS11055	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWH56_RS11060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AWH56_RS11090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_RS11095	COG2056	Na+-H+ antiporter family
AWH56_RS11105	COG1268	BioY protein
AWH56_RS11320	COG0456	acetyltransferase
AWH56_RS11335	COG4372	Transposase
AWH56_RS11425	COG4372	Transposase
AWH56_RS11485	COG4974	Belongs to the 'phage' integrase family
AWH56_RS11530	COG0456	acetyltransferase
AWH56_RS11530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AWH56_RS11585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_RS11650	COG1484	DNA-dependent DNA replication
AWH56_RS11720	COG4372	Transposase
AWH56_RS11745	COG0494	nUDIX hydrolase
AWH56_RS11750	COG1595	DNA-templated transcription, initiation
AWH56_RS11770	COG0456	acetyltransferase
AWH56_RS11825	COG5646	InterPro IPR014922
AWH56_RS11835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWH56_RS11840	COG1131	(ABC) transporter
AWH56_RS11850	COG1136	(ABC) transporter
AWH56_RS11855	COG2205	protein histidine kinase activity
AWH56_RS11860	COG0745	RESPONSE REGULATOR receiver
AWH56_RS11875	COG2814	Major facilitator Superfamily
AWH56_RS11910	COG1131	(ABC) transporter
AWH56_RS11920	COG1404	Belongs to the peptidase S8 family
AWH56_RS11925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AWH56_RS11935	COG1131	(ABC) transporter
AWH56_RS11940	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWH56_RS11955	COG1854	S-ribosylhomocysteine lyase activity
AWH56_RS11970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AWH56_RS11975	COG0644	oxidoreductase
AWH56_RS11985	COG1335	isochorismatase
AWH56_RS11990	COG1522	sequence-specific DNA binding
AWH56_RS11995	COG0436	Aminotransferase
AWH56_RS12005	COG0733	neurotransmitter:sodium symporter activity
AWH56_RS12015	COG1098	S1 RNA binding domain
AWH56_RS12020	COG2155	Conserved Protein
AWH56_RS12025	COG1979	alcohol dehydrogenase
AWH56_RS12030	COG0166	Belongs to the GPI family
AWH56_RS12045	COG0640	Transcriptional regulator
AWH56_RS12050	COG5001	Diguanylate cyclase
AWH56_RS12050	COG3300	MHYT domain
AWH56_RS12055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AWH56_RS12075	COG1802	Transcriptional regulator
AWH56_RS12080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWH56_RS12085	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWH56_RS12090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_RS12100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_RS12105	COG1063	alcohol dehydrogenase
AWH56_RS12110	COG0800	Aldolase
AWH56_RS12115	COG1312	Catalyzes the dehydration of D-mannonate
AWH56_RS12120	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS12130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AWH56_RS12150	COG2972	Histidine kinase
AWH56_RS12165	COG0673	inositol 2-dehydrogenase activity
AWH56_RS12195	COG2226	methyltransferase
AWH56_RS12210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWH56_RS12235	COG3639	organic phosphonate transmembrane transporter activity
AWH56_RS12240	COG3639	organic phosphonate transmembrane transporter activity
AWH56_RS12245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWH56_RS12255	COG0561	phosphatase activity
AWH56_RS12290	COG4152	abc transporter atp-binding protein
AWH56_RS12320	COG0840	transmembrane signaling receptor activity
AWH56_RS12325	COG3634	alkyl hydroperoxide reductase activity
AWH56_RS12330	COG0450	alkyl hydroperoxide reductase
AWH56_RS12335	COG1929	Belongs to the glycerate kinase type-1 family
AWH56_RS12345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_RS12350	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS12355	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWH56_RS12380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_RS12385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AWH56_RS12390	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWH56_RS12400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_RS12405	COG1484	DNA-dependent DNA replication
AWH56_RS12415	COG3835	regulator
AWH56_RS12425	COG3275	phosphorelay sensor kinase activity
AWH56_RS12440	COG0346	lactoylglutathione lyase activity
AWH56_RS12445	COG0579	oxidoreductase
AWH56_RS12450	COG2721	sulfolactate sulfo-lyase activity
AWH56_RS12475	COG1120	ATPase activity
AWH56_RS12480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWH56_RS12485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_RS12490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_RS12495	COG1408	metallophosphoesterase
AWH56_RS12500	COG1368	sulfuric ester hydrolase activity
AWH56_RS12510	COG1253	flavin adenine dinucleotide binding
AWH56_RS12520	COG4536	flavin adenine dinucleotide binding
AWH56_RS12545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_RS12550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AWH56_RS12580	COG0470	DNA polymerase III
AWH56_RS12630	COG4974	Belongs to the 'phage' integrase family
AWH56_RS12655	COG0582	viral genome integration into host DNA
AWH56_RS12660	COG4974	Belongs to the 'phage' integrase family
AWH56_RS12740	COG0398	Pfam SNARE associated Golgi protein
AWH56_RS12750	COG4134	Bacterial extracellular solute-binding protein
AWH56_RS12765	COG3842	ATPase activity
AWH56_RS12775	COG0589	response to stress
AWH56_RS12805	COG2190	(PTS) system
AWH56_RS12810	COG3711	transcriptional antiterminator
AWH56_RS12815	COG1263	PTS System
AWH56_RS12815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWH56_RS12820	COG1621	beta-fructofuranosidase activity
AWH56_RS12830	COG0534	Mate efflux family protein
AWH56_RS12850	COG1755	Isoprenylcysteine carboxyl methyltransferase
AWH56_RS12855	COG3424	synthase
AWH56_RS12860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWH56_RS12865	COG0129	dihydroxy-acid dehydratase activity
AWH56_RS12895	COG1070	Carbohydrate kinase
AWH56_RS12900	COG1737	Transcriptional regulator
AWH56_RS12905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_RS12910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_RS12915	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_RS12915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_RS12935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_RS12940	COG0733	neurotransmitter:sodium symporter activity
AWH56_RS12955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWH56_RS12955	COG0723	plastoquinol--plastocyanin reductase activity
AWH56_RS12960	COG0561	phosphatase activity
AWH56_RS12970	COG3290	protein histidine kinase activity
AWH56_RS12970	COG0840	transmembrane signaling receptor activity
AWH56_RS12990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AWH56_RS13000	COG0243	molybdopterin cofactor binding
AWH56_RS13005	COG0437	4 iron, 4 sulfur cluster binding
AWH56_RS13030	COG4585	Histidine kinase
AWH56_RS13045	COG0175	sulfate reduction
AWH56_RS13055	COG0306	phosphate transporter
AWH56_RS13060	COG0529	Catalyzes the synthesis of activated sulfate
AWH56_RS13085	COG0750	zinc metalloprotease
AWH56_RS13095	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_RS13105	COG3290	protein histidine kinase activity
AWH56_RS13105	COG3829	transcription factor binding
AWH56_RS13110	COG3290	protein histidine kinase activity
AWH56_RS13110	COG3829	transcription factor binding
AWH56_RS13115	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS13120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AWH56_RS13125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_RS13130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_RS13135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWH56_RS13140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWH56_RS13145	COG2186	Transcriptional regulator
AWH56_RS13160	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_RS13175	COG1506	peptidase
AWH56_RS13190	COG1725	Transcriptional regulator
AWH56_RS13195	COG1131	(ABC) transporter
AWH56_RS13215	COG0697	spore germination
AWH56_RS13270	COG1164	Oligoendopeptidase f
AWH56_RS13275	COG1278	Cold shock
AWH56_RS13280	COG2205	protein histidine kinase activity
AWH56_RS13285	COG2205	protein histidine kinase activity
AWH56_RS13295	COG1272	protein, Hemolysin III
AWH56_RS13320	COG1131	(ABC) transporter
AWH56_RS13340	COG0586	Pfam SNARE associated Golgi protein
AWH56_RS13345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AWH56_RS13350	COG0183	Belongs to the thiolase family
AWH56_RS13360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AWH56_RS13370	COG0437	4 iron, 4 sulfur cluster binding
AWH56_RS13385	COG0746	molybdenum cofactor guanylyltransferase activity
AWH56_RS13390	COG0303	'Molybdopterin
AWH56_RS13395	COG0303	'Molybdopterin
AWH56_RS13405	COG3290	protein histidine kinase activity
AWH56_RS13405	COG0840	transmembrane signaling receptor activity
AWH56_RS13415	COG2814	Major facilitator Superfamily
AWH56_RS13420	COG0494	nUDIX hydrolase
AWH56_RS13430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWH56_RS13435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWH56_RS13440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AWH56_RS13445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWH56_RS13450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AWH56_RS13455	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWH56_RS13460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWH56_RS13465	COG0297	glycogen (starch) synthase activity
AWH56_RS13470	COG0058	SHG alpha-glucan phosphorylase activity
AWH56_RS13485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AWH56_RS13490	COG2267	carboxylic ester hydrolase activity
AWH56_RS13505	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AWH56_RS13515	COG0288	reversible hydration of carbon dioxide
AWH56_RS13520	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AWH56_RS13525	COG1242	4 iron, 4 sulfur cluster binding
AWH56_RS13535	COG2814	Major facilitator Superfamily
AWH56_RS13540	COG3706	GGDEF domain
AWH56_RS13545	COG0495	leucyl-tRNA aminoacylation
AWH56_RS13555	COG2081	HI0933 family
AWH56_RS13560	COG1414	Transcriptional regulator
AWH56_RS13565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_RS13575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_RS13585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWH56_RS13590	COG1063	alcohol dehydrogenase
AWH56_RS13595	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS13600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AWH56_RS13605	COG0800	Aldolase
AWH56_RS13610	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS13630	COG2244	polysaccharide biosynthetic process
AWH56_RS13640	COG0772	Belongs to the SEDS family
AWH56_RS13645	COG0772	Belongs to the SEDS family
AWH56_RS13650	COG1187	pseudouridine synthase activity
AWH56_RS13655	COG1349	DNA-binding transcription factor activity
AWH56_RS13665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWH56_RS13685	COG0714	Associated with various cellular activities
AWH56_RS13690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWH56_RS13700	COG1380	Effector of murein hydrolase LrgA
AWH56_RS13705	COG1346	cytolysis
AWH56_RS13725	COG1523	belongs to the glycosyl hydrolase 13 family
AWH56_RS13730	COG0510	thiamine kinase activity
AWH56_RS13755	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWH56_RS13760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_RS13770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_RS13775	COG1309	transcriptional regulator
AWH56_RS13795	COG3290	protein histidine kinase activity
AWH56_RS13800	COG0494	nUDIX hydrolase
AWH56_RS13810	COG0217	transcriptional regulatory protein
AWH56_RS13815	COG0346	lactoylglutathione lyase activity
AWH56_RS13825	COG2323	membrane
AWH56_RS13835	COG1363	Peptidase, m42
AWH56_RS13840	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AWH56_RS13845	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWH56_RS13870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS13875	COG1316	TRANSCRIPTIONal
AWH56_RS13880	COG4848	Belongs to the UPF0354 family
AWH56_RS13885	COG1674	ftsk spoiiie
AWH56_RS13900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_RS13925	COG0668	transmembrane transport
AWH56_RS13940	COG1595	DNA-templated transcription, initiation
AWH56_RS13950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWH56_RS13955	COG2309	aminopeptidase activity
AWH56_RS13965	COG4980	gas vesicle protein
AWH56_RS13970	COG3118	belongs to the thioredoxin family
AWH56_RS13975	COG0849	cell division
AWH56_RS13980	COG1605	Chorismate mutase
AWH56_RS13980	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AWH56_RS13995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AWH56_RS14005	COG1846	Transcriptional regulator
AWH56_RS14010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AWH56_RS14015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWH56_RS14020	COG0123	including yeast histone deacetylase and acetoin utilization protein
AWH56_RS14025	COG0517	IMP dehydrogenase activity
AWH56_RS14030	COG0454	-acetyltransferase
AWH56_RS14035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWH56_RS14055	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWH56_RS14060	COG2203	Gaf domain
AWH56_RS14060	COG2199	diguanylate cyclase activity
AWH56_RS14065	COG1309	transcriptional regulator
AWH56_RS14070	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AWH56_RS14080	COG1104	cysteine desulfurase activity
AWH56_RS14095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWH56_RS14100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AWH56_RS14105	COG0616	signal peptide processing
AWH56_RS14110	COG1714	RDD family
AWH56_RS14120	COG3874	Sporulation protein YtfJ
AWH56_RS14125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AWH56_RS14130	COG0827	DNA restriction-modification system
AWH56_RS14135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWH56_RS14140	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWH56_RS14155	COG0596	Alpha beta hydrolase
AWH56_RS14160	COG0137	argininosuccinate synthase activity
AWH56_RS14165	COG0165	Argininosuccinate lyase
AWH56_RS14170	COG0589	response to stress
AWH56_RS14180	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS14190	COG0006	proline dipeptidase activity
AWH56_RS14205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AWH56_RS14215	COG4109	DRTGG domain
AWH56_RS14225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWH56_RS14245	COG0587	DNA-directed DNA polymerase activity
AWH56_RS14250	COG0281	malic enzyme
AWH56_RS14255	COG2186	Transcriptional regulator
AWH56_RS14260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWH56_RS14265	COG0825	malonyl-CoA metabolic process
AWH56_RS14270	COG0205	6-phosphofructokinase activity
AWH56_RS14280	COG3030	protein affecting phage T7 exclusion by the F plasmid
AWH56_RS14285	COG0840	transmembrane signaling receptor activity
AWH56_RS14290	COG0628	permease
AWH56_RS14295	COG2707	UPF0756 membrane protein
AWH56_RS14300	COG0372	Belongs to the citrate synthase family
AWH56_RS14305	COG0538	isocitrate dehydrogenase activity
AWH56_RS14310	COG0039	L-malate dehydrogenase activity
AWH56_RS14325	COG0745	RESPONSE REGULATOR receiver
AWH56_RS14330	COG5002	protein histidine kinase activity
AWH56_RS14335	COG0330	HflC and HflK could
AWH56_RS14340	COG0330	HflC and HflK could
AWH56_RS14345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWH56_RS14345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWH56_RS14350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWH56_RS14355	COG1971	Probably functions as a manganese efflux pump
AWH56_RS14365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AWH56_RS14375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWH56_RS14380	COG3611	Membrane attachment protein
AWH56_RS14385	COG1484	DNA-dependent DNA replication
AWH56_RS14390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AWH56_RS14400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWH56_RS14415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWH56_RS14420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AWH56_RS14425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWH56_RS14430	COG3326	Membrane
AWH56_RS14435	COG0398	Pfam SNARE associated Golgi protein
AWH56_RS14450	COG1363	Peptidase, m42
AWH56_RS14465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWH56_RS14470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWH56_RS14475	COG0072	phenylalanine-tRNA ligase activity
AWH56_RS14475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWH56_RS14485	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWH56_RS14490	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AWH56_RS14495	COG1286	toxin biosynthetic process
AWH56_RS14505	COG1193	negative regulation of DNA recombination
AWH56_RS14510	COG3766	membrane
AWH56_RS14520	COG0318	PFAM AMP-dependent synthetase and ligase
AWH56_RS14525	COG0318	PFAM AMP-dependent synthetase and ligase
AWH56_RS14540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWH56_RS14540	COG2010	Cytochrome c
AWH56_RS14545	COG3278	Belongs to the heme-copper respiratory oxidase family
AWH56_RS14550	COG1309	transcriptional regulator
AWH56_RS14555	COG1024	Enoyl-CoA hydratase
AWH56_RS14560	COG2086	electron transfer activity
AWH56_RS14565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AWH56_RS14570	COG3118	belongs to the thioredoxin family
AWH56_RS14585	COG1719	4-vinyl reductase, 4VR
AWH56_RS14590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWH56_RS14595	COG2009	succinate dehydrogenase
AWH56_RS14600	COG1053	succinate dehydrogenase
AWH56_RS14605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AWH56_RS14610	COG0824	Thioesterase
AWH56_RS14615	COG2197	response regulator
AWH56_RS14620	COG2031	fatty acid transporter
AWH56_RS14625	COG1846	Transcriptional regulator
AWH56_RS14635	COG5401	PFAM Sporulation and spore germination
AWH56_RS14645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWH56_RS14650	COG0622	Phosphoesterase
AWH56_RS14670	COG0129	dihydroxy-acid dehydratase activity
AWH56_RS14675	COG0028	Belongs to the TPP enzyme family
AWH56_RS14680	COG0440	acetolactate synthase activity
AWH56_RS14685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AWH56_RS14690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWH56_RS14695	COG0473	3-isopropylmalate dehydrogenase activity
AWH56_RS14700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AWH56_RS14705	COG0066	3-isopropylmalate dehydratase activity
AWH56_RS14710	COG1477	protein flavinylation
AWH56_RS14710	COG0457	Tetratricopeptide repeat
AWH56_RS14715	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWH56_RS14720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWH56_RS14725	COG1067	ATP-dependent peptidase activity
AWH56_RS14725	COG0470	DNA polymerase III
AWH56_RS14730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AWH56_RS14735	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWH56_RS14750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AWH56_RS14755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWH56_RS14760	COG0181	hydroxymethylbilane synthase activity
AWH56_RS14770	COG0113	porphobilinogen synthase activity
AWH56_RS14775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AWH56_RS14780	COG1388	LysM domain
AWH56_RS14805	COG1136	(ABC) transporter
AWH56_RS14810	COG0525	valine-tRNA ligase activity
AWH56_RS14820	COG0285	dihydrofolate synthase activity
AWH56_RS14825	COG0285	dihydrofolate synthase activity
AWH56_RS14840	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AWH56_RS14860	COG1027	Aspartate ammonia-lyase
AWH56_RS14870	COG2003	Belongs to the UPF0758 family
AWH56_RS14875	COG1077	Cell shape determining protein MreB Mrl
AWH56_RS14880	COG1792	Involved in formation and maintenance of cell shape
AWH56_RS14890	COG0850	regulation of cytokinetic process
AWH56_RS14895	COG2894	cell division
AWH56_RS14900	COG0483	inositol monophosphate 1-phosphatase activity
AWH56_RS14910	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWH56_RS14925	COG0739	heme binding
AWH56_RS14930	COG1994	Peptidase M50
AWH56_RS14935	COG1530	ribonuclease E activity
AWH56_RS14940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AWH56_RS14945	COG2868	ribosomal protein
AWH56_RS14950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AWH56_RS14955	COG1234	tRNA 3'-trailer cleavage
AWH56_RS14960	COG0840	transmembrane signaling receptor activity
AWH56_RS14965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWH56_RS14970	COG0573	inorganic phosphate transmembrane transporter activity
AWH56_RS14975	COG0581	inorganic phosphate transmembrane transporter activity
AWH56_RS14980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWH56_RS14985	COG0704	Plays a role in the regulation of phosphate uptake
AWH56_RS14990	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWH56_RS14995	COG1074	ATP-dependent DNA helicase activity
AWH56_RS15015	COG0840	transmembrane signaling receptor activity
AWH56_RS15015	COG5278	phosphoserine phosphatase activity
AWH56_RS15020	COG0686	Belongs to the AlaDH PNT family
AWH56_RS15035	COG0840	transmembrane signaling receptor activity
AWH56_RS15040	COG5001	Diguanylate cyclase
AWH56_RS15040	COG3300	MHYT domain
AWH56_RS15070	COG1484	DNA-dependent DNA replication
AWH56_RS15080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_RS15090	COG2186	Transcriptional regulator
AWH56_RS15095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AWH56_RS15110	COG1366	Belongs to the anti-sigma-factor antagonist family
AWH56_RS15130	COG0640	Transcriptional regulator
AWH56_RS15135	COG0798	PFAM Bile acid sodium symporter
AWH56_RS15140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWH56_RS15145	COG2258	MOSC domain
AWH56_RS15150	COG0439	Biotin carboxylase
AWH56_RS15155	COG1309	transcriptional regulator
AWH56_RS15160	COG0511	ligase activity, forming carbon-carbon bonds
AWH56_RS15165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AWH56_RS15170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_RS15170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_RS15175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_RS15175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AWH56_RS15180	COG1703	isobutyryl-CoA mutase activity
AWH56_RS15215	COG4372	Transposase
AWH56_RS15220	COG0785	Cytochrome C biogenesis protein
AWH56_RS15235	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS15240	COG0840	transmembrane signaling receptor activity
AWH56_RS15245	COG0501	Belongs to the peptidase M48B family
AWH56_RS15270	COG0393	Putative heavy-metal-binding
AWH56_RS15285	COG0534	Mate efflux family protein
AWH56_RS15290	COG2207	Transcriptional regulator
AWH56_RS15290	COG1917	Cupin 2, conserved barrel domain protein
AWH56_RS15300	COG2182	Extracellular solute-binding protein
AWH56_RS15305	COG1175	transmembrane transport
AWH56_RS15310	COG3833	ABC-type maltose transport systems, permease component
AWH56_RS15325	COG0628	permease
AWH56_RS15330	COG0205	6-phosphofructokinase activity
AWH56_RS15335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_RS15345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_RS15360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AWH56_RS15375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWH56_RS15400	COG1858	cytochrome C peroxidase
AWH56_RS15420	COG0561	phosphatase activity
AWH56_RS15430	COG3336	cytochrome c oxidase
AWH56_RS15445	COG0303	'Molybdopterin
AWH56_RS15450	COG1763	Mo-molybdopterin cofactor biosynthetic process
AWH56_RS15455	COG0314	molybdopterin synthase activity
AWH56_RS15460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AWH56_RS15465	COG2151	metal-sulfur cluster biosynthetic enzyme
AWH56_RS15480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AWH56_RS15485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AWH56_RS15490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AWH56_RS15500	COG0505	Belongs to the CarA family
AWH56_RS15505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWH56_RS15510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWH56_RS15515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_RS15525	COG0535	radical SAM domain protein
AWH56_RS15535	COG0243	molybdopterin cofactor binding
AWH56_RS15540	COG0437	4 iron, 4 sulfur cluster binding
AWH56_RS15555	COG2223	nitrite transmembrane transporter activity
AWH56_RS15560	COG2223	nitrite transmembrane transporter activity
AWH56_RS15565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_RS15585	COG2267	carboxylic ester hydrolase activity
AWH56_RS15590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWH56_RS15600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWH56_RS15605	COG1744	ABC transporter substrate-binding protein PnrA-like
AWH56_RS15620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_RS15625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWH56_RS15635	COG4758	membrane
AWH56_RS15640	COG4585	Histidine kinase
AWH56_RS15645	COG2197	response regulator
AWH56_RS15650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWH56_RS15655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWH56_RS15660	COG5504	Zn-dependent protease
AWH56_RS15675	COG0180	Tryptophanyl-tRNA synthetase
AWH56_RS15685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS15690	COG1418	mRNA catabolic process
AWH56_RS15695	COG0166	Belongs to the GPI family
AWH56_RS15705	COG0456	acetyltransferase
AWH56_RS15720	COG1393	Belongs to the ArsC family
AWH56_RS15725	COG0861	Integral membrane protein TerC family
AWH56_RS15730	COG4862	establishment of competence for transformation
AWH56_RS15735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWH56_RS15740	COG4469	Competence protein
AWH56_RS15745	COG1164	Oligoendopeptidase f
AWH56_RS15750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWH56_RS15755	COG2346	COG2346, Truncated hemoglobins
AWH56_RS15760	COG0741	lytic transglycosylase activity
AWH56_RS15765	COG4116	CYTH
AWH56_RS15775	COG2357	RelA SpoT domain protein
AWH56_RS15780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AWH56_RS15785	COG0564	pseudouridine synthase activity
AWH56_RS15795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AWH56_RS15805	COG0589	response to stress
AWH56_RS15805	COG0475	glutathione-regulated potassium exporter activity
AWH56_RS15825	COG1216	Glycosyl transferase, family 2
AWH56_RS15870	COG0457	Tetratricopeptide repeat
AWH56_RS15870	COG0463	Glycosyl transferase, family 2
AWH56_RS15880	COG0463	Glycosyl transferase, family 2
AWH56_RS15920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWH56_RS15925	COG0673	inositol 2-dehydrogenase activity
AWH56_RS15935	COG4641	Protein conserved in bacteria
AWH56_RS15935	COG1388	LysM domain
AWH56_RS15955	COG0210	DNA helicase
AWH56_RS15970	COG2153	protein acetylation
AWH56_RS15975	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AWH56_RS15980	COG2382	esterase
AWH56_RS15990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AWH56_RS16010	COG4974	Belongs to the 'phage' integrase family
AWH56_RS16050	COG1609	Transcriptional regulator
AWH56_RS16055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_RS16060	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_RS16060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_RS16065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_RS16065	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_RS16070	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWH56_RS16080	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_RS16085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AWH56_RS16090	COG1929	Belongs to the glycerate kinase type-1 family
AWH56_RS16095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_RS16160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS16165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AWH56_RS16170	COG5001	Diguanylate cyclase
AWH56_RS16200	COG1131	(ABC) transporter
AWH56_RS16215	COG0535	radical SAM domain protein
AWH56_RS16230	COG3437	response regulator, receiver
AWH56_RS16230	COG4999	Histidine kinase
AWH56_RS16230	COG3850	Histidine kinase
AWH56_RS16230	COG2205	protein histidine kinase activity
AWH56_RS16235	COG5002	protein histidine kinase activity
AWH56_RS16235	COG0784	Response regulator, receiver
AWH56_RS16240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AWH56_RS16245	COG5002	protein histidine kinase activity
AWH56_RS16250	COG0778	Nitroreductase
AWH56_RS16280	COG0071	Belongs to the small heat shock protein (HSP20) family
AWH56_RS16295	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWH56_RS16330	COG0589	response to stress
AWH56_RS16335	COG0668	transmembrane transport
AWH56_RS16355	COG2224	Isocitrate lyase
AWH56_RS16360	COG2171	N-acyltransferase activity
AWH56_RS16365	COG1473	amidohydrolase
AWH56_RS16375	COG0668	transmembrane transport
AWH56_RS16380	COG0450	alkyl hydroperoxide reductase
AWH56_RS16385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS16405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWH56_RS16435	COG0022	dehydrogenase e1 component
AWH56_RS16440	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWH56_RS16450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS16455	COG4129	membrane
AWH56_RS16460	COG0726	polysaccharide deacetylase
AWH56_RS16490	COG1982	Orn Lys Arg decarboxylase major
AWH56_RS16495	COG4476	Belongs to the UPF0223 family
AWH56_RS16500	COG4493	Belongs to the UPF0637 family
AWH56_RS16510	COG0483	inositol monophosphate 1-phosphatase activity
AWH56_RS16520	COG1217	gtp-binding protein TYPA
AWH56_RS16530	COG4896	Protein conserved in bacteria
AWH56_RS16545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AWH56_RS16550	COG2066	Belongs to the glutaminase family
AWH56_RS16555	COG4838	Belongs to the UPF0358 family
AWH56_RS16565	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWH56_RS16570	COG1612	heme a metabolic process
AWH56_RS16575	COG0109	protoheme IX farnesyltransferase activity
AWH56_RS16580	COG2010	Cytochrome c
AWH56_RS16580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWH56_RS16590	COG1845	cytochrome c oxidase, subunit III
AWH56_RS16595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AWH56_RS16605	COG0628	permease
AWH56_RS16620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWH56_RS16625	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AWH56_RS16630	COG2340	Cysteine-rich secretory protein family
AWH56_RS16665	COG4294	response to UV
AWH56_RS16670	COG3679	Belongs to the UPF0342 family
AWH56_RS16675	COG4471	UPF0298 protein
AWH56_RS16685	COG0742	ribosomal rna small subunit methyltransferase
AWH56_RS16690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWH56_RS16695	COG3314	Sporulation integral membrane protein YlbJ
AWH56_RS16700	COG1752	Esterase of the alpha-beta hydrolase superfamily
AWH56_RS16705	COG3480	Lon protease (S16) C-terminal proteolytic domain
AWH56_RS16710	COG1323	Belongs to the UPF0348 family
AWH56_RS16715	COG1399	metal-binding, possibly nucleic acid-binding protein
AWH56_RS16720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AWH56_RS16725	COG1024	Enoyl-CoA hydratase
AWH56_RS16735	COG0454	-acetyltransferase
AWH56_RS16740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AWH56_RS16755	COG2001	Belongs to the MraZ family
AWH56_RS16760	COG0275	rRNA processing
AWH56_RS16770	COG0768	penicillin binding
AWH56_RS16775	COG0768	penicillin binding
AWH56_RS16780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWH56_RS16785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWH56_RS16790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWH56_RS16800	COG0772	Belongs to the SEDS family
AWH56_RS16805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWH56_RS16810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWH56_RS16815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWH56_RS16820	COG3879	Bacterial protein of unknown function (DUF881)
AWH56_RS16830	COG3856	small basic protein
AWH56_RS16835	COG0849	cell division
AWH56_RS16840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AWH56_RS16850	COG1191	sigma factor activity
AWH56_RS16855	COG1191	sigma factor activity
AWH56_RS16860	COG1873	PFAM PRC-barrel domain
AWH56_RS16865	COG1496	oxidoreductase activity
AWH56_RS16870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWH56_RS16875	COG1799	cell septum assembly
AWH56_RS16880	COG0762	integral membrane protein
AWH56_RS16885	COG2302	S4 RNA-binding domain
AWH56_RS16890	COG3599	regulation of cell shape
AWH56_RS16895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWH56_RS16900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AWH56_RS16910	COG0564	pseudouridine synthase activity
AWH56_RS16915	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AWH56_RS16925	COG0540	Belongs to the ATCase OTCase family
AWH56_RS16930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWH56_RS16940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWH56_RS16950	COG0167	dihydroorotate dehydrogenase activity
AWH56_RS16960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AWH56_RS16970	COG1132	(ABC) transporter
AWH56_RS16975	COG1132	(ABC) transporter
AWH56_RS16985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWH56_RS16990	COG1561	YicC-like family, N-terminal region
AWH56_RS16995	COG2052	Domain of unknown function (DUF370)
AWH56_RS17000	COG0194	GDP metabolic process
AWH56_RS17005	COG1758	RNA polymerase activity
AWH56_RS17010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWH56_RS17015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWH56_RS17025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWH56_RS17030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWH56_RS17030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWH56_RS17035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AWH56_RS17040	COG0631	protein serine/threonine phosphatase activity
AWH56_RS17045	COG0515	serine threonine protein kinase
AWH56_RS17045	COG2815	serine threonine protein kinase
AWH56_RS17050	COG1162	GTPase activity
AWH56_RS17055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWH56_RS17060	COG3859	Proton-coupled thiamine transporter YuaJ
AWH56_RS17065	COG1564	THIamine pyrophosphokinase
AWH56_RS17075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWH56_RS17080	COG1302	Protein conserved in bacteria
AWH56_RS17085	COG1461	Dihydroxyacetone kinase
AWH56_RS17090	COG1307	EDD domain protein, DegV family
AWH56_RS17095	COG1760	l-serine dehydratase
AWH56_RS17100	COG1760	l-serine dehydratase
AWH56_RS17105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWH56_RS17110	COG1349	DNA-binding transcription factor activity
AWH56_RS17120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AWH56_RS17125	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS17130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWH56_RS17135	COG0571	ribonuclease III activity
AWH56_RS17140	COG4840	Belongs to the UPF0435 family
AWH56_RS17145	COG1196	nuclear chromosome segregation
AWH56_RS17150	COG0552	protein localization to endoplasmic reticulum
AWH56_RS17155	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AWH56_RS17160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWH56_RS17165	COG0228	four-way junction DNA binding
AWH56_RS17170	COG1837	Belongs to the UPF0109 family
AWH56_RS17190	COG0335	large ribosomal subunit rRNA binding
AWH56_RS17215	COG2257	FlhB HrpN YscU SpaS Family
AWH56_RS17230	COG0045	succinate-CoA ligase (ADP-forming) activity
AWH56_RS17235	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AWH56_RS17240	COG0758	DNA mediated transformation
AWH56_RS17245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWH56_RS17250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AWH56_RS17255	COG4974	Belongs to the 'phage' integrase family
AWH56_RS17260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AWH56_RS17265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AWH56_RS17270	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AWH56_RS17275	COG1815	bacterial-type flagellum-dependent cell motility
AWH56_RS17280	COG1558	bacterial-type flagellum-dependent cell motility
AWH56_RS17285	COG1677	Flagellar hook-basal body complex protein FliE
AWH56_RS17290	COG1766	The M ring may be actively involved in energy transduction
AWH56_RS17295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWH56_RS17300	COG1317	bacterial-type flagellum organization
AWH56_RS17305	COG1157	protein secretion by the type III secretion system
AWH56_RS17325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AWH56_RS17340	COG1582	Flagellar protein (FlbD)
AWH56_RS17345	COG1580	Controls the rotational direction of flagella during chemotaxis
AWH56_RS17350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWH56_RS17355	COG1776	CheC inhibitor of MCP methylation
AWH56_RS17355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWH56_RS17360	COG2201	protein-glutamate methylesterase activity
AWH56_RS17365	COG3190	flagellar
AWH56_RS17370	COG1338	Plays a role in the flagellum-specific transport system
AWH56_RS17375	COG1987	bacterial-type flagellum assembly
AWH56_RS17380	COG1684	flagellar biosynthetic protein fliR
AWH56_RS17385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWH56_RS17405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWH56_RS17410	COG1419	protein localization to endoplasmic reticulum
AWH56_RS17415	COG0455	bacterial-type flagellum organization
AWH56_RS17420	COG2201	protein-glutamate methylesterase activity
AWH56_RS17425	COG0643	Histidine kinase
AWH56_RS17425	COG2198	Histidine kinase
AWH56_RS17430	COG0835	chemotaxis
AWH56_RS17435	COG1776	CheC inhibitor of MCP methylation
AWH56_RS17440	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AWH56_RS17450	COG1191	sigma factor activity
AWH56_RS17470	COG0052	Belongs to the universal ribosomal protein uS2 family
AWH56_RS17475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWH56_RS17480	COG0528	UMP kinase activity
AWH56_RS17485	COG0233	cytoplasmic translational termination
AWH56_RS17490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWH56_RS17495	COG4589	Belongs to the CDS family
AWH56_RS17500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AWH56_RS17505	COG0750	zinc metalloprotease
AWH56_RS17520	COG2176	DNA-directed DNA polymerase activity
AWH56_RS17525	COG0779	Required for maturation of 30S ribosomal subunits
AWH56_RS17530	COG0195	Participates in both transcription termination and antitermination
AWH56_RS17535	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWH56_RS17540	COG1358	cellular component organization or biogenesis
AWH56_RS17545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AWH56_RS17555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWH56_RS17565	COG0196	riboflavin kinase activity
AWH56_RS17570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWH56_RS17575	COG1185	polyribonucleotide nucleotidyltransferase activity
AWH56_RS17580	COG0726	polysaccharide deacetylase
AWH56_RS17585	COG0612	Peptidase, M16
AWH56_RS17590	COG1873	PFAM PRC-barrel domain
AWH56_RS17595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWH56_RS17600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWH56_RS17605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWH56_RS17610	COG0527	aspartate kinase activity
AWH56_RS17620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWH56_RS17625	COG0740	serine-type endopeptidase activity
AWH56_RS17635	COG1674	ftsk spoiiie
AWH56_RS17640	COG2188	Transcriptional regulator
AWH56_RS17645	COG0612	Peptidase, M16
AWH56_RS17650	COG0612	Peptidase, M16
AWH56_RS17655	COG0300	oxidoreductase activity
AWH56_RS17670	COG1426	Protein conserved in bacteria
AWH56_RS17675	COG1666	GTP binding
AWH56_RS17680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWH56_RS17685	COG1546	Belongs to the CinA family
AWH56_RS17685	COG1058	Belongs to the CinA family
AWH56_RS17690	COG0513	Belongs to the DEAD box helicase family
AWH56_RS17695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWH56_RS17700	COG1418	mRNA catabolic process
AWH56_RS17705	COG1692	metallophosphoesterase
AWH56_RS17710	COG2359	stage V sporulation protein S
AWH56_RS17715	COG0674	pyruvate-flavodoxin oxidoreductase activity
AWH56_RS17715	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AWH56_RS17720	COG1013	pyruvate-flavodoxin oxidoreductase activity
AWH56_RS17725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWH56_RS17730	COG4550	Control of competence regulator ComK, YlbF/YmcA
AWH56_RS17745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWH56_RS17750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWH56_RS17755	COG2521	methyltransferase
AWH56_RS17755	COG2136	Putative SAM-dependent methyltransferase
AWH56_RS17760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWH56_RS17765	COG1923	regulation of RNA biosynthetic process
AWH56_RS17775	COG0464	growth
AWH56_RS17780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWH56_RS17785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AWH56_RS17790	COG0789	Transcriptional regulator
AWH56_RS17795	COG0174	glutamine synthetase
AWH56_RS17800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AWH56_RS17810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_RS17815	COG4224	UPF0291 protein
AWH56_RS17820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AWH56_RS17830	COG3763	UPF0154 protein
AWH56_RS17835	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AWH56_RS17840	COG1132	(ABC) transporter
AWH56_RS17845	COG1132	(ABC) transporter
AWH56_RS17850	COG1937	Protein conserved in bacteria
AWH56_RS17855	COG2217	Heavy metal translocating P-type atpase
AWH56_RS17865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS17875	COG4846	Membrane protein involved in cytochrome C biogenesis
AWH56_RS17885	COG0626	cystathionine gamma-synthase activity
AWH56_RS17890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AWH56_RS17895	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AWH56_RS17900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWH56_RS17930	COG2223	nitrite transmembrane transporter activity
AWH56_RS17935	COG3773	Cell wall hydrolase
AWH56_RS17975	COG0733	neurotransmitter:sodium symporter activity
AWH56_RS17985	COG2169	Transcriptional regulator
AWH56_RS17990	COG0697	spore germination
AWH56_RS18005	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS18015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_RS18030	COG0154	amidase activity
AWH56_RS18070	COG1414	Transcriptional regulator
AWH56_RS18075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWH56_RS18165	COG1484	DNA-dependent DNA replication
AWH56_RS18195	COG1695	Transcriptional regulator
AWH56_RS18450	COG1214	PFAM Peptidase M22, glycoprotease
AWH56_RS18450	COG0456	acetyltransferase
AWH56_RS18470	COG1484	DNA-dependent DNA replication
AWH56_RS18530	COG4974	Belongs to the 'phage' integrase family
AWH56_RS18535	COG0582	viral genome integration into host DNA
AWH56_RS18540	COG4974	Belongs to the 'phage' integrase family
AWH56_RS18595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWH56_RS18680	COG1595	DNA-templated transcription, initiation
AWH56_RS18745	COG4372	Transposase
AWH56_RS18765	COG1247	-acetyltransferase
AWH56_RS18820	COG4974	Belongs to the 'phage' integrase family
AWH56_RS18825	COG0582	viral genome integration into host DNA
AWH56_RS18830	COG4974	Belongs to the 'phage' integrase family
AWH56_RS18925	COG1160	GTP binding
AWH56_RS18960	COG1253	flavin adenine dinucleotide binding
AWH56_RS18975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWH56_RS18975	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWH56_RS19015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AWH56_RS19030	COG2323	membrane
AWH56_RS19050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AWH56_RS19060	COG0398	Pfam SNARE associated Golgi protein
AWH56_RS19085	COG0464	growth
AWH56_RS19090	COG0824	Thioesterase
AWH56_RS19100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AWH56_RS19105	COG0613	PHP domain protein
AWH56_RS19110	COG0328	RNA-DNA hybrid ribonuclease activity
AWH56_RS19115	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AWH56_RS19125	COG1924	4 iron, 4 sulfur cluster binding
AWH56_RS19140	COG2200	EAL domain
AWH56_RS19150	COG1704	LemA family
AWH56_RS19160	COG3290	protein histidine kinase activity
AWH56_RS19160	COG0840	transmembrane signaling receptor activity
AWH56_RS19190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWH56_RS19200	COG1131	(ABC) transporter
AWH56_RS19205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWH56_RS19210	COG1725	Transcriptional regulator
AWH56_RS19215	COG1131	(ABC) transporter
AWH56_RS19230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWH56_RS19240	COG0784	Response regulator, receiver
AWH56_RS19240	COG0835	chemotaxis
AWH56_RS19250	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AWH56_RS19255	COG1151	hydroxylamine reductase activity
AWH56_RS19265	COG0674	pyruvate-flavodoxin oxidoreductase activity
AWH56_RS19270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AWH56_RS19275	COG1418	mRNA catabolic process
AWH56_RS19280	COG1388	LysM domain
AWH56_RS19280	COG0791	NLP P60 protein
AWH56_RS19290	COG2814	Major facilitator Superfamily
AWH56_RS19335	COG0697	spore germination
AWH56_RS19350	COG3852	Histidine kinase
AWH56_RS19365	COG1111	helicase
AWH56_RS19365	COG1205	dead DEAH box helicase
AWH56_RS19370	COG3359	exonuclease
AWH56_RS19375	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AWH56_RS19380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AWH56_RS19380	COG0617	tRNA 3'-terminal CCA addition
AWH56_RS19380	COG0517	IMP dehydrogenase activity
AWH56_RS19385	COG2176	DNA-directed DNA polymerase activity
AWH56_RS19400	COG4474	Belongs to the UPF0398 family
AWH56_RS19405	COG3599	regulation of cell shape
AWH56_RS19410	COG0328	RNA-DNA hybrid ribonuclease activity
AWH56_RS19420	COG0116	Belongs to the methyltransferase superfamily
AWH56_RS19435	COG1199	ATP-dependent helicase activity
AWH56_RS19445	COG2030	dehydratase
AWH56_RS19470	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS19485	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AWH56_RS19490	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AWH56_RS19495	COG4585	Histidine kinase
AWH56_RS19500	COG2197	response regulator
AWH56_RS19510	COG1131	(ABC) transporter
AWH56_RS19515	COG0842	Transport permease protein
AWH56_RS19515	COG1511	domain protein
AWH56_RS19525	COG2843	Capsule synthesis protein
AWH56_RS19530	COG0584	glycerophosphoryl diester phosphodiesterase
AWH56_RS19535	COG0183	Belongs to the thiolase family
AWH56_RS19545	COG0183	Belongs to the thiolase family
AWH56_RS19550	COG3858	chitin binding
AWH56_RS19555	COG1832	CoA-binding protein
AWH56_RS19560	COG0187	DNA topoisomerase II activity
AWH56_RS19565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWH56_RS19570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_RS19600	COG1086	Polysaccharide biosynthesis protein
AWH56_RS19605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWH56_RS19610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWH56_RS19615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AWH56_RS19625	COG0728	peptidoglycan biosynthetic process
AWH56_RS19630	COG5039	Polysaccharide pyruvyl transferase
AWH56_RS19635	COG3944	biosynthesis protein
AWH56_RS19640	COG0489	protein tyrosine kinase activity
AWH56_RS19645	COG0438	transferase activity, transferring glycosyl groups
AWH56_RS19665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWH56_RS19670	COG4974	Belongs to the 'phage' integrase family
AWH56_RS19675	COG0501	Belongs to the peptidase M48B family
AWH56_RS19680	COG1714	RDD family
AWH56_RS19690	COG2133	pyrroloquinoline quinone binding
AWH56_RS19695	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS19700	COG3340	Belongs to the peptidase S51 family
AWH56_RS19705	COG1595	DNA-templated transcription, initiation
AWH56_RS19735	COG0583	DNA-binding transcription factor activity
AWH56_RS19760	COG1090	epimerase
AWH56_RS19765	COG0673	inositol 2-dehydrogenase activity
AWH56_RS19770	COG1164	Oligoendopeptidase f
AWH56_RS19780	COG1231	oxidoreductase activity
AWH56_RS19805	COG1285	pathogenesis
AWH56_RS19810	COG2199	diguanylate cyclase activity
AWH56_RS19810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWH56_RS19825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWH56_RS19840	COG1012	belongs to the aldehyde dehydrogenase family
AWH56_RS19845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AWH56_RS19850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWH56_RS19855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWH56_RS19860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWH56_RS19865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AWH56_RS19880	COG1509	lysine 2,3-aminomutase activity
AWH56_RS19885	COG3829	transcription factor binding
AWH56_RS19915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AWH56_RS19920	COG0456	acetyltransferase
AWH56_RS19930	COG3695	enzyme binding
AWH56_RS19935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWH56_RS19940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_RS19950	COG1376	ErfK ybiS ycfS ynhG family protein
AWH56_RS19960	COG2322	membrane
AWH56_RS19975	COG3852	Histidine kinase
AWH56_RS20005	COG1413	lyase activity
AWH56_RS20020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWH56_RS20080	COG2094	Belongs to the DNA glycosylase MPG family
AWH56_RS20090	COG0546	phosphoglycolate phosphatase activity
AWH56_RS20170	COG0739	heme binding
AWH56_RS20170	COG1196	nuclear chromosome segregation
AWH56_RS20170	COG0741	lytic transglycosylase activity
AWH56_RS20195	COG1757	Na H antiporter
AWH56_RS20200	COG1388	LysM domain
AWH56_RS20200	COG0791	NLP P60 protein
AWH56_RS20215	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AWH56_RS20220	COG1131	(ABC) transporter
AWH56_RS20225	COG2755	lipolytic protein G-D-S-L family
AWH56_RS20250	COG1388	LysM domain
AWH56_RS20250	COG3858	chitin binding
AWH56_RS20260	COG5001	Diguanylate cyclase
AWH56_RS20265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWH56_RS20270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWH56_RS20275	COG1116	anion transmembrane transporter activity
AWH56_RS20280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AWH56_RS20295	COG2720	vancomycin resistance protein
AWH56_RS20325	COG3192	ethanolamine utilization protein
AWH56_RS20340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AWH56_RS20355	COG0861	Integral membrane protein TerC family
AWH56_RS20420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWH56_RS20425	COG0569	domain protein
AWH56_RS20440	COG0312	modulator of DNA gyrase
AWH56_RS20445	COG0312	modulator of DNA gyrase
AWH56_RS20450	COG3180	Ammonia monooxygenase
AWH56_RS20460	COG0385	Bile acid
AWH56_RS20470	COG1959	2 iron, 2 sulfur cluster binding
AWH56_RS20495	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AWH56_RS20550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWH56_RS20575	COG1131	(ABC) transporter
AWH56_RS20580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AWH56_RS20655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWH56_RS20675	COG4555	ABC transporter
AWH56_RS20685	COG1595	DNA-templated transcription, initiation
AWH56_RS20730	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AWH56_RS20770	COG1484	DNA-dependent DNA replication
AWH56_RS20795	COG0028	Belongs to the TPP enzyme family
AWH56_RS20795	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AWH56_RS20890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AWH56_RS20895	COG1278	Cold shock
AWH56_RS20915	COG0477	Major facilitator Superfamily
AWH56_RS20920	COG0584	glycerophosphoryl diester phosphodiesterase
AWH56_RS20980	COG1363	Peptidase, m42
AWH56_RS20990	COG2362	D-Aminopeptidase
AWH56_RS20995	COG2201	protein-glutamate methylesterase activity
AWH56_RS21000	COG3852	Histidine kinase
AWH56_RS21010	COG0444	Belongs to the ABC transporter superfamily
AWH56_RS21020	COG0601	transmembrane transport
AWH56_RS21025	COG0747	negative chemotaxis
AWH56_RS21035	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AWH56_RS21045	COG1764	response to oxidative stress
AWH56_RS21060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWH56_RS21070	COG0489	protein tyrosine kinase activity
AWH56_RS21090	COG0437	4 iron, 4 sulfur cluster binding
AWH56_RS21095	COG0243	molybdopterin cofactor binding
AWH56_RS21105	COG1295	ribonuclease BN
AWH56_RS21130	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AWH56_RS21140	COG2154	pterin-4-alpha-carbinolamine dehydratase
AWH56_RS21145	COG3186	Phenylalanine-4-hydroxylase
AWH56_RS21150	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AWH56_RS21150	COG2885	chlorophyll binding
AWH56_RS21170	COG1192	Involved in chromosome partitioning
AWH56_RS21180	COG2311	Membrane
AWH56_RS21190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWH56_RS21235	COG1199	ATP-dependent helicase activity
AWH56_RS21235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWH56_RS21250	COG0667	Aldo Keto reductase
AWH56_RS21255	COG1999	signal sequence binding
AWH56_RS21295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_RS21310	COG4948	Mandelate Racemase Muconate Lactonizing
AWH56_RS21320	COG3314	Sporulation integral membrane protein YlbJ
AWH56_RS21350	COG3012	SEC-C Motif Domain Protein
AWH56_RS21355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_RS21365	COG1132	(ABC) transporter
AWH56_RS21400	COG0534	Mate efflux family protein
AWH56_RS21455	COG0577	efflux transmembrane transporter activity
AWH56_RS21485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWH56_RS21495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWH56_RS21520	COG1472	Belongs to the glycosyl hydrolase 3 family
AWH56_RS21540	COG0562	UDP-galactopyranose mutase
AWH56_RS21560	COG1136	(ABC) transporter
AWH56_RS21595	COG0456	acetyltransferase
AWH56_RS21595	COG1846	Transcriptional regulator
AWH56_RS21605	COG0534	Mate efflux family protein
AWH56_RS21645	COG3655	Transcriptional regulator
AWH56_RS21670	COG3708	Transcriptional regulator
AWH56_RS21670	COG2207	Transcriptional regulator
AWH56_RS21680	COG1556	Lactate utilization protein
AWH56_RS21685	COG1139	Iron-sulfur cluster binding protein
AWH56_RS21690	COG0247	lactate metabolic process
AWH56_RS21710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWH56_RS21715	COG0583	DNA-binding transcription factor activity
AWH56_RS21725	COG1811	Na channel or pump
AWH56_RS21730	COG0789	Transcriptional regulator
AWH56_RS21730	COG4978	Transcriptional regulator
AWH56_RS21740	COG2514	catechol 2,3-dioxygenase activity
AWH56_RS21745	COG2259	Doxx family
AWH56_RS21760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWH56_RS21760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWH56_RS21765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_RS21790	COG3708	Transcriptional regulator
AWH56_RS21790	COG2207	Transcriptional regulator
AWH56_RS21840	COG1061	Type III restriction enzyme res subunit
AWH56_RS21850	COG0537	adenosine 5'-monophosphoramidase activity
AWH56_RS21855	COG1201	RNA secondary structure unwinding
AWH56_RS21870	COG1061	Type III restriction enzyme res subunit
AWH56_RS21875	COG2807	transmembrane transport
AWH56_RS21880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWH56_RS21885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWH56_RS21890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_RS21980	COG1752	Esterase of the alpha-beta hydrolase superfamily
AWH56_RS21985	COG3300	MHYT domain
AWH56_RS21985	COG5001	Diguanylate cyclase
AWH56_RS22025	COG2197	response regulator
AWH56_RS22035	COG4585	Histidine kinase
AWH56_RS22040	COG1131	(ABC) transporter
AWH56_RS22120	COG3012	SEC-C Motif Domain Protein
AWH56_RS22130	COG5002	protein histidine kinase activity
AWH56_RS22150	COG3339	Conserved Protein
AWH56_RS22175	COG1752	Esterase of the alpha-beta hydrolase superfamily
AWH56_RS22185	COG2610	gluconate transmembrane transporter activity
AWH56_RS22195	COG2084	Dehydrogenase
AWH56_RS22200	COG1802	Transcriptional regulator
AWH56_RS22205	COG1505	serine-type exopeptidase activity
AWH56_RS22235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWH56_RS22255	COG0604	alcohol dehydrogenase
AWH56_RS22275	COG2814	Major facilitator Superfamily
AWH56_RS22280	COG0823	Involved in the tonB-independent uptake of proteins
AWH56_RS22280	COG1506	peptidase
AWH56_RS22280	COG4946	Tricorn protease homolog
AWH56_RS22290	COG3655	Transcriptional regulator
AWH56_RS22305	COG0861	Integral membrane protein TerC family
AWH56_RS22320	COG1668	transmembrane transport
AWH56_RS22325	COG4152	abc transporter atp-binding protein
AWH56_RS22340	COG0563	adenylate kinase activity
AWH56_RS22470	COG5002	protein histidine kinase activity
AWH56_RS22490	COG1307	EDD domain protein, DegV family
AWH56_RS22495	COG1132	(ABC) transporter
AWH56_RS22505	COG5002	protein histidine kinase activity
AWH56_RS22510	COG5002	protein histidine kinase activity
AWH56_RS22520	COG0516	GMP reductase activity
AWH56_RS22530	COG1725	Transcriptional regulator
AWH56_RS22535	COG1131	(ABC) transporter
AWH56_RS22550	COG3739	integral membrane protein
AWH56_RS22555	COG0697	spore germination
AWH56_RS22560	COG1966	Carbon starvation protein
AWH56_RS22575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWH56_RS22585	COG0501	Belongs to the peptidase M48B family
AWH56_RS22595	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AWH56_RS22600	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AWH56_RS22650	COG0840	transmembrane signaling receptor activity
AWH56_RS22655	COG2323	membrane
AWH56_RS22690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWH56_RS22710	COG1228	amidohydrolase
AWH56_RS22745	COG0436	Aminotransferase
AWH56_RS22750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWH56_RS22795	COG1272	protein, Hemolysin III
AWH56_RS22810	COG1408	metallophosphoesterase
AWH56_RS22840	COG2514	catechol 2,3-dioxygenase activity
AWH56_RS22855	COG0697	spore germination
AWH56_RS22860	COG1114	Component of the transport system for branched-chain amino acids
AWH56_RS22870	COG2323	membrane
AWH56_RS22890	COG1376	ErfK ybiS ycfS ynhG family protein
AWH56_RS22925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AWH56_RS22935	COG3832	glyoxalase III activity
AWH56_RS22940	COG1664	Polymer-forming cytoskeletal
AWH56_RS22945	COG0789	Transcriptional regulator
AWH56_RS22955	COG1113	amino acid transport
AWH56_RS22960	COG1280	lysine exporter protein (LysE YggA)
AWH56_RS22985	COG0456	acetyltransferase
AWH56_RS23000	COG0662	Cupin 2, conserved barrel domain protein
AWH56_RS23005	COG1714	RDD family
AWH56_RS23020	COG2135	peptidase activity
AWH56_RS23035	COG3546	catalase activity
AWH56_RS23050	COG0473	3-isopropylmalate dehydrogenase activity
AWH56_RS23055	COG3559	Exporter of polyketide antibiotics
AWH56_RS23060	COG1131	(ABC) transporter
AWH56_RS23065	COG2860	membrane
AWH56_RS23150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_RS23185	COG1309	transcriptional regulator
AWH56_RS23210	COG2244	polysaccharide biosynthetic process
AWH56_RS23215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AWH56_RS23220	COG1846	Transcriptional regulator
AWH56_RS23230	COG0681	Belongs to the peptidase S26 family
AWH56_RS23265	COG1595	DNA-templated transcription, initiation
AWH56_RS23280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_RS23290	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS23295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AWH56_RS23295	COG0604	alcohol dehydrogenase
AWH56_RS23295	COG3321	synthase
AWH56_RS23295	COG4221	oxidoreductase activity
AWH56_RS23310	COG3852	Histidine kinase
AWH56_RS23330	COG0243	molybdopterin cofactor binding
AWH56_RS23335	COG0697	spore germination
AWH56_RS23340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWH56_RS23345	COG0708	Exodeoxyribonuclease III
AWH56_RS23360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWH56_RS23370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AWH56_RS23380	COG0656	L-ascorbic acid biosynthetic process
AWH56_RS23400	COG1231	oxidoreductase activity
AWH56_RS23415	COG4895	conserved protein (DUF2196)
AWH56_RS23425	COG1587	Uroporphyrinogen-III synthase
AWH56_RS23435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AWH56_RS23445	COG4608	Belongs to the ABC transporter superfamily
AWH56_RS23450	COG0444	Belongs to the ABC transporter superfamily
AWH56_RS23455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWH56_RS23460	COG0601	transmembrane transport
AWH56_RS23485	COG1063	alcohol dehydrogenase
AWH56_RS23490	COG1960	acyl-CoA dehydrogenase activity
AWH56_RS23500	COG0693	protein deglycase activity
AWH56_RS23505	COG5522	Integral membrane protein (intg_mem_TP0381)
AWH56_RS23510	COG0789	Transcriptional regulator
AWH56_RS23515	COG2176	DNA-directed DNA polymerase activity
AWH56_RS23525	COG0004	ammonium transporteR
AWH56_RS23545	COG1329	Transcriptional regulator
AWH56_RS23550	COG0583	DNA-binding transcription factor activity
AWH56_RS23555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWH56_RS23560	COG2340	Cysteine-rich secretory protein family
AWH56_RS23585	COG2153	protein acetylation
AWH56_RS23590	COG1132	(ABC) transporter
AWH56_RS23595	COG1132	(ABC) transporter
AWH56_RS23620	COG3437	response regulator, receiver
AWH56_RS23625	COG0277	FAD linked oxidase domain protein
AWH56_RS23630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWH56_RS23635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AWH56_RS23655	COG1393	Belongs to the ArsC family
AWH56_RS23660	COG3850	Histidine kinase
AWH56_RS23660	COG5002	protein histidine kinase activity
AWH56_RS23665	COG0745	RESPONSE REGULATOR receiver
AWH56_RS23670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AWH56_RS23675	COG0398	Pfam SNARE associated Golgi protein
AWH56_RS23710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWH56_RS23735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AWH56_RS23740	COG0583	DNA-binding transcription factor activity
AWH56_RS23745	COG2814	Major facilitator Superfamily
AWH56_RS23750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWH56_RS23755	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWH56_RS23765	COG1469	GTP cyclohydrolase I activity
AWH56_RS23770	COG2070	2-Nitropropane dioxygenase
AWH56_RS23785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWH56_RS23790	COG2223	nitrite transmembrane transporter activity
AWH56_RS23805	COG3830	Belongs to the UPF0237 family
AWH56_RS23880	COG2409	Drug exporters of the RND superfamily
AWH56_RS23880	COG1033	growth of symbiont in host cell
AWH56_RS23890	COG2962	Rard protein
AWH56_RS23915	COG0488	(ABC) transporter
AWH56_RS23920	COG0488	(ABC) transporter
AWH56_RS23940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWH56_RS23955	COG0826	peptidase U32
AWH56_RS23965	COG1942	4-Oxalocrotonate Tautomerase
AWH56_RS23970	COG0477	Major facilitator Superfamily
AWH56_RS23980	COG0702	epimerase
AWH56_RS24005	COG5609	conserved protein (DUF2294)
AWH56_RS24015	COG3546	catalase activity
AWH56_RS24035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AWH56_RS24035	COG1587	Uroporphyrinogen-III synthase
AWH56_RS24045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AWH56_RS24050	COG0436	Aminotransferase
AWH56_RS24070	COG2309	aminopeptidase activity
AWH56_RS24095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AWH56_RS24100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWH56_RS24110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AWH56_RS24115	COG1984	allophanate hydrolase subunit 2
AWH56_RS24120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AWH56_RS24125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWH56_RS24130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWH56_RS24135	COG0419	ATPase involved in DNA repair
AWH56_RS24195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWH56_RS24225	COG1555	photosystem II stabilization
AWH56_RS24225	COG1596	polysaccharide export
AWH56_RS24230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWH56_RS24230	COG0574	Belongs to the PEP-utilizing enzyme family
AWH56_RS24240	COG2814	Major facilitator Superfamily
AWH56_RS24275	COG3383	formate dehydrogenase (NAD+) activity
AWH56_RS24315	COG1428	Deoxynucleoside kinase
AWH56_RS24320	COG1428	Deoxynucleoside kinase
AWH56_RS24325	COG0514	ATP-dependent DNA helicase (RecQ)
AWH56_RS24350	COG0243	molybdopterin cofactor binding
AWH56_RS24370	COG0243	molybdopterin cofactor binding
AWH56_RS24375	COG0348	domain, Protein
AWH56_RS24380	COG0437	4 iron, 4 sulfur cluster binding
AWH56_RS24395	COG0409	Hydrogenase expression formation protein
AWH56_RS24400	COG0298	carbon dioxide binding
AWH56_RS24405	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AWH56_RS24410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AWH56_RS24430	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AWH56_RS24440	COG0805	protein transport
AWH56_RS24445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AWH56_RS24465	COG1929	Belongs to the glycerate kinase type-1 family
AWH56_RS24495	COG0326	Molecular chaperone. Has ATPase activity
AWH56_RS24505	COG1028	Short-chain dehydrogenase reductase Sdr
AWH56_RS24545	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWH56_RS24560	COG0194	GDP metabolic process
AWH56_RS24585	COG3428	Bacterial PH domain
AWH56_RS24590	COG3402	PFAM membrane-flanked domain
AWH56_RS24600	COG0490	domain, Protein
AWH56_RS24600	COG0471	metal ion transport
AWH56_RS24605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AWH56_RS24610	COG1335	isochorismatase
AWH56_RS24620	COG1234	tRNA 3'-trailer cleavage
AWH56_RS24630	COG1528	Iron-storage protein
AWH56_RS24640	COG0789	Transcriptional regulator
AWH56_RS24650	COG3331	DNA recombination
AWH56_RS24655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWH56_RS24655	COG4499	WXG100 protein secretion system (Wss), protein YukC
AWH56_RS24665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWH56_RS24670	COG3935	DnaD domain protein
AWH56_RS24675	COG0017	Asparaginyl-tRNA synthetase
AWH56_RS24680	COG0436	Aminotransferase
AWH56_RS24695	COG0402	S-adenosylhomocysteine deaminase activity
AWH56_RS24705	COG1199	ATP-dependent helicase activity
AWH56_RS24705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWH56_RS24725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AWH56_RS24735	COG0617	tRNA 3'-terminal CCA addition
AWH56_RS24740	COG0438	transferase activity, transferring glycosyl groups
AWH56_RS24745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AWH56_RS24750	COG1803	Methylglyoxal synthase
AWH56_RS24755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWH56_RS24760	COG1694	Mazg nucleotide pyrophosphohydrolase
AWH56_RS24765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AWH56_RS24770	COG2738	Putative neutral zinc metallopeptidase
AWH56_RS24780	COG4347	Protein of unknown function (DUF1405)
AWH56_RS24790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AWH56_RS24805	COG5582	Belongs to the UPF0302 family
AWH56_RS24815	COG0457	Tetratricopeptide repeat
AWH56_RS24825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AWH56_RS24830	COG0287	Prephenate dehydrogenase
AWH56_RS24835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWH56_RS24840	COG0159	tryptophan synthase activity
AWH56_RS24845	COG0133	tryptophan synthase activity
AWH56_RS24850	COG0135	phosphoribosylanthranilate isomerase activity
AWH56_RS24855	COG0134	indole-3-glycerol-phosphate synthase activity
AWH56_RS24860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWH56_RS24870	COG4401	Chorismate mutase type I
AWH56_RS24875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWH56_RS24880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWH56_RS24885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AWH56_RS24890	COG0105	UTP biosynthetic process
AWH56_RS24895	COG0142	geranyltranstransferase activity
AWH56_RS24900	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AWH56_RS24905	COG0163	prenyltransferase activity
AWH56_RS24910	COG0109	protoheme IX farnesyltransferase activity
AWH56_RS24915	COG2226	methyltransferase
AWH56_RS24920	COG0142	geranyltranstransferase activity
AWH56_RS24930	COG0302	gtp cyclohydrolase
AWH56_RS24940	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AWH56_RS24960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWH56_RS24965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AWH56_RS24970	COG1160	GTP binding
AWH56_RS24985	COG1304	FMN binding
AWH56_RS24995	COG0204	Acyl-transferase
AWH56_RS25000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AWH56_RS25015	COG2959	enzyme of heme biosynthesis
AWH56_RS25020	COG3773	Cell wall hydrolase
AWH56_RS25020	COG3409	Peptidoglycan-binding domain 1 protein
AWH56_RS25025	COG0646	methionine synthase
AWH56_RS25025	COG1410	methionine synthase
AWH56_RS25030	COG0646	methionine synthase
AWH56_RS25030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AWH56_RS25035	COG0626	cystathionine gamma-synthase activity
AWH56_RS25040	COG0626	cystathionine gamma-synthase activity
AWH56_RS25055	COG2339	peptidase activity
AWH56_RS25065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWH56_RS25070	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWH56_RS25075	COG4862	establishment of competence for transformation
AWH56_RS25080	COG0789	Transcriptional regulator
AWH56_RS25085	COG1408	metallophosphoesterase
AWH56_RS25145	COG1266	CAAX protease self-immunity
AWH56_RS25150	COG0514	ATP-dependent DNA helicase (RecQ)
AWH56_RS25155	COG4955	Helix-turn-helix domain
AWH56_RS25160	COG1141	Ferredoxin
AWH56_RS25170	COG2186	Transcriptional regulator
AWH56_RS25180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AWH56_RS25190	COG0739	heme binding
AWH56_RS25195	COG2720	vancomycin resistance protein
AWH56_RS25200	COG2096	Adenosyltransferase
AWH56_RS25210	COG0588	phosphoglycerate mutase activity
AWH56_RS25215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AWH56_RS25220	COG1492	cobalamin metabolic process
AWH56_RS25230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWH56_RS25235	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AWH56_RS25240	COG1120	ATPase activity
AWH56_RS25245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWH56_RS25250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWH56_RS25255	COG0521	Mo-molybdopterin cofactor biosynthetic process
AWH56_RS25260	COG5002	protein histidine kinase activity
AWH56_RS25265	COG0745	RESPONSE REGULATOR receiver
AWH56_RS25270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWH56_RS25275	COG1333	cytochrome c biogenesis protein
AWH56_RS25280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS25285	COG1187	pseudouridine synthase activity
AWH56_RS25290	COG0700	Nucleoside recognition
AWH56_RS25295	COG2715	membrane protein required for spore maturation
AWH56_RS25300	COG1686	Belongs to the peptidase S11 family
AWH56_RS25305	COG2323	membrane
AWH56_RS25320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_RS25350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWH56_RS25370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWH56_RS25375	COG1547	Domain of unknown function (DUF309)
AWH56_RS25380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AWH56_RS25385	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWH56_RS25385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWH56_RS25390	COG0307	riboflavin synthase, alpha
AWH56_RS25395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AWH56_RS25395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AWH56_RS25400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWH56_RS25405	COG1705	Flagellar rod assembly protein muramidase FlgJ
AWH56_RS25405	COG1388	LysM domain
AWH56_RS25410	COG0019	diaminopimelate decarboxylase activity
AWH56_RS25415	COG0697	spore germination
AWH56_RS25430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWH56_RS25455	COG2172	sigma factor antagonist activity
AWH56_RS25460	COG1366	Belongs to the anti-sigma-factor antagonist family
AWH56_RS25465	COG1686	Belongs to the peptidase S11 family
AWH56_RS25475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AWH56_RS25495	COG4974	Belongs to the 'phage' integrase family
AWH56_RS25505	COG0735	belongs to the Fur family
AWH56_RS25510	COG1300	Membrane
AWH56_RS25515	COG1379	DNA repair
AWH56_RS25520	COG0494	nUDIX hydrolase
AWH56_RS25535	COG0667	Aldo Keto reductase
AWH56_RS25540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWH56_RS25545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWH56_RS25550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWH56_RS25555	COG1968	undecaprenyl-diphosphatase activity
AWH56_RS25565	COG0701	Predicted permease
AWH56_RS25570	COG3689	TIGRFAM TIGR03943 family protein
AWH56_RS25575	COG0133	tryptophan synthase activity
AWH56_RS25580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWH56_RS25585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWH56_RS25605	COG2414	aldehyde ferredoxin oxidoreductase
AWH56_RS25610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AWH56_RS25615	COG2226	methyltransferase
AWH56_RS25645	COG3344	reverse transcriptase
AWH56_RS25680	COG1227	inorganic diphosphatase activity
AWH56_RS25685	COG2233	PERMEase
AWH56_RS25695	COG3829	transcription factor binding
AWH56_RS25705	COG4720	Psort location CytoplasmicMembrane, score
AWH56_RS25710	COG0367	asparagine synthase
AWH56_RS25720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWH56_RS25735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWH56_RS25745	COG0300	oxidoreductase activity
AWH56_RS25760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWH56_RS25770	COG0527	aspartate kinase activity
AWH56_RS25775	COG0789	Transcriptional regulator
AWH56_RS25780	COG2861	carbohydrate metabolic process
AWH56_RS25790	COG0517	IMP dehydrogenase activity
AWH56_RS25800	COG1902	pentaerythritol trinitrate reductase activity
AWH56_RS25815	COG1728	Protein conserved in bacteria
AWH56_RS25835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWH56_RS25845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWH56_RS25860	COG2195	Cleaves the N-terminal amino acid of tripeptides
AWH56_RS25865	COG0346	lactoylglutathione lyase activity
AWH56_RS25875	COG1376	ErfK ybiS ycfS ynhG family protein
AWH56_RS25880	COG4129	membrane
AWH56_RS25885	COG1126	abc transporter atp-binding protein
AWH56_RS25890	COG0765	amino acid transport
AWH56_RS25895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWH56_RS25910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWH56_RS25915	COG4565	transcriptional regulatory protein
AWH56_RS25920	COG3290	protein histidine kinase activity
AWH56_RS25945	COG1484	DNA-dependent DNA replication
AWH56_RS25960	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWH56_RS25965	COG0022	dehydrogenase e1 component
AWH56_RS25970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWH56_RS25975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWH56_RS25980	COG3426	butyrate kinase activity
AWH56_RS25990	COG0280	phosphate acetyltransferase
AWH56_RS25995	COG3829	transcription factor binding
AWH56_RS25995	COG3290	protein histidine kinase activity
AWH56_RS26010	COG0463	Glycosyl transferase, family 2
AWH56_RS26025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AWH56_RS26030	COG1882	Formate acetyltransferase
AWH56_RS26035	COG0745	RESPONSE REGULATOR receiver
AWH56_RS26040	COG0750	zinc metalloprotease
AWH56_RS26045	COG0497	DNA recombination
AWH56_RS26050	COG1438	arginine binding
AWH56_RS26055	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWH56_RS26060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AWH56_RS26085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWH56_RS26090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWH56_RS26095	COG1302	Protein conserved in bacteria
AWH56_RS26100	COG0439	Biotin carboxylase
AWH56_RS26105	COG0511	ligase activity, forming carbon-carbon bonds
AWH56_RS26150	COG3854	ATPases associated with a variety of cellular activities
AWH56_RS26165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWH56_RS26170	COG0006	proline dipeptidase activity
AWH56_RS26175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AWH56_RS26190	COG1321	iron dependent repressor
AWH56_RS26195	COG1533	DNA photolyase activity
AWH56_RS26200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWH56_RS26210	COG0095	Lipoate-protein ligase
AWH56_RS26215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWH56_RS26220	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWH56_RS26225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWH56_RS26230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWH56_RS26235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AWH56_RS26280	COG4537	Required for transformation and DNA binding
AWH56_RS26300	COG1459	type II secretion system
AWH56_RS26305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWH56_RS26335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWH56_RS26350	COG0011	TIGRFAM Protein of
AWH56_RS26360	COG0351	phosphomethylpyrimidine kinase
AWH56_RS26370	COG0352	thiamine-phosphate diphosphorylase activity