locus-tag	class	description
I6H46_RS00010	COG1349	DNA-binding transcription factor activity
I6H46_RS00015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6H46_RS00030	COG1131	(ABC) transporter
I6H46_RS00035	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6H46_RS00040	COG1473	amidohydrolase
I6H46_RS00045	COG0596	Alpha beta hydrolase
I6H46_RS00050	COG1278	Cold shock
I6H46_RS00055	COG2226	methyltransferase
I6H46_RS00060	COG0525	valine-tRNA ligase activity
I6H46_RS00065	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H46_RS00070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H46_RS00070	COG0574	Belongs to the PEP-utilizing enzyme family
I6H46_RS00090	COG0745	RESPONSE REGULATOR receiver
I6H46_RS00095	COG2205	protein histidine kinase activity
I6H46_RS00100	COG1301	dicarboxylic acid transport
I6H46_RS00115	COG0653	protein targeting
I6H46_RS00120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6H46_RS00125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H46_RS00135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H46_RS00145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6H46_RS00150	COG0823	Involved in the tonB-independent uptake of proteins
I6H46_RS00150	COG1506	peptidase
I6H46_RS00150	COG4946	Tricorn protease homolog
I6H46_RS00155	COG1295	ribonuclease BN
I6H46_RS00160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H46_RS00170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H46_RS00175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H46_RS00190	COG0305	Participates in initiation and elongation during chromosome replication
I6H46_RS00195	COG0359	binds to the 23S rRNA
I6H46_RS00200	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6H46_RS00225	COG1024	Enoyl-CoA hydratase
I6H46_RS00235	COG1477	protein flavinylation
I6H46_RS00245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H46_RS00250	COG0572	uridine kinase
I6H46_RS00255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H46_RS00265	COG0590	tRNA wobble adenosine to inosine editing
I6H46_RS00275	COG1686	Belongs to the peptidase S11 family
I6H46_RS00295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H46_RS00300	COG0758	DNA mediated transformation
I6H46_RS00310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H46_RS00315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H46_RS00325	COG0642	Histidine kinase
I6H46_RS00330	COG1136	(ABC) transporter
I6H46_RS00340	COG0335	large ribosomal subunit rRNA binding
I6H46_RS00345	COG0336	Belongs to the RNA methyltransferase TrmD family
I6H46_RS00350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H46_RS00360	COG0228	four-way junction DNA binding
I6H46_RS00365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H46_RS00370	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6H46_RS00385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H46_RS00390	COG1288	antiporter activity
I6H46_RS00395	COG0549	Belongs to the carbamate kinase family
I6H46_RS00400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H46_RS00405	COG2235	arginine
I6H46_RS00410	COG2207	Transcriptional regulator
I6H46_RS00410	COG3708	Transcriptional regulator
I6H46_RS00510	COG0251	oxidation-reduction process
I6H46_RS00525	COG0018	arginyl-trna synthetase
I6H46_RS00535	COG0826	peptidase U32
I6H46_RS00545	COG0072	phenylalanine-tRNA ligase activity
I6H46_RS00545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_RS00555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H46_RS00560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H46_RS00570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H46_RS00625	COG5012	cobalamin binding
I6H46_RS00635	COG0281	malic enzyme
I6H46_RS00640	COG0114	fumarate hydratase activity
I6H46_RS00645	COG0583	DNA-binding transcription factor activity
I6H46_RS00650	COG1794	racemase activity, acting on amino acids and derivatives
I6H46_RS00655	COG1301	dicarboxylic acid transport
I6H46_RS00660	COG1027	Aspartate ammonia-lyase
I6H46_RS00670	COG0584	glycerophosphoryl diester phosphodiesterase
I6H46_RS00675	COG1924	4 iron, 4 sulfur cluster binding
I6H46_RS00690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H46_RS00695	COG0629	single-stranded DNA binding
I6H46_RS00700	COG0360	Binds together with S18 to 16S ribosomal RNA
I6H46_RS00705	COG3191	aminopeptidase activity
I6H46_RS00720	COG0640	Transcriptional regulator
I6H46_RS00730	COG4824	toxin secretion phage lysis holin
I6H46_RS00765	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6H46_RS00790	COG0686	Belongs to the AlaDH PNT family
I6H46_RS00805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H46_RS00810	COG3842	ATPase activity
I6H46_RS00820	COG5426	von Willebrand factor, type A
I6H46_RS00825	COG0395	ABC-type sugar transport system, permease component
I6H46_RS00830	COG1175	transmembrane transport
I6H46_RS00835	COG1653	transport
I6H46_RS00845	COG1131	(ABC) transporter
I6H46_RS00850	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H46_RS00905	COG3340	Belongs to the peptidase S51 family
I6H46_RS01030	COG0519	Catalyzes the synthesis of GMP from XMP
I6H46_RS01040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H46_RS01045	COG0751	glycine-tRNA ligase activity
I6H46_RS01050	COG0752	glycyl-tRNA synthetase alpha subunit
I6H46_RS01055	COG1381	Involved in DNA repair and RecF pathway recombination
I6H46_RS01060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H46_RS01065	COG0295	cytidine deaminase activity
I6H46_RS01070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H46_RS01080	COG1702	phosphate starvation-inducible protein PhoH
I6H46_RS01090	COG4864	UPF0365 protein
I6H46_RS01095	COG1030	water channel activity
I6H46_RS01100	COG1304	FMN binding
I6H46_RS01105	COG1316	TRANSCRIPTIONal
I6H46_RS01110	COG0561	phosphatase activity
I6H46_RS01125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H46_RS01145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H46_RS01150	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H46_RS01155	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H46_RS01160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H46_RS01165	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H46_RS01175	COG2239	Acts as a magnesium transporter
I6H46_RS01180	COG0793	Belongs to the peptidase S41A family
I6H46_RS01205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H46_RS01210	COG0556	nucleotide-excision repair
I6H46_RS01215	COG2217	Heavy metal translocating P-type atpase
I6H46_RS01250	COG0791	NLP P60 protein
I6H46_RS01270	COG0765	amino acid transport
I6H46_RS01290	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6H46_RS01305	COG2022	thiamine diphosphate biosynthetic process
I6H46_RS01310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6H46_RS01325	COG0473	3-isopropylmalate dehydrogenase activity
I6H46_RS01335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H46_RS01340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6H46_RS01345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H46_RS01350	COG1979	alcohol dehydrogenase
I6H46_RS01450	COG3693	PFAM glycoside hydrolase, family 10
I6H46_RS01450	COG2382	esterase
I6H46_RS01485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H46_RS01505	COG2226	methyltransferase
I6H46_RS01535	COG0733	neurotransmitter:sodium symporter activity
I6H46_RS01540	COG0402	S-adenosylhomocysteine deaminase activity
I6H46_RS01545	COG2252	PERMEase
I6H46_RS01575	COG1473	amidohydrolase
I6H46_RS01580	COG1546	Belongs to the CinA family
I6H46_RS01580	COG1058	Belongs to the CinA family
I6H46_RS01585	COG3608	succinylglutamate desuccinylase aspartoacylase
I6H46_RS01585	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6H46_RS01590	COG3608	succinylglutamate desuccinylase aspartoacylase
I6H46_RS01590	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6H46_RS01595	COG1083	cytidylyl-transferase
I6H46_RS01600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H46_RS01605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H46_RS01625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H46_RS01645	COG0402	S-adenosylhomocysteine deaminase activity
I6H46_RS01650	COG0493	'glutamate synthase
I6H46_RS01650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H46_RS01665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H46_RS01670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H46_RS01675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H46_RS01680	COG0709	Synthesizes selenophosphate from selenide and ATP
I6H46_RS01685	COG0425	Belongs to the sulfur carrier protein TusA family
I6H46_RS01700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H46_RS01705	COG4149	molybdate abc transporter
I6H46_RS01710	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6H46_RS01720	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H46_RS01725	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H46_RS01735	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6H46_RS01750	COG0019	diaminopimelate decarboxylase activity
I6H46_RS01760	COG1177	transmembrane transport
I6H46_RS01770	COG3842	ATPase activity
I6H46_RS01780	COG0789	Transcriptional regulator
I6H46_RS01805	COG1454	alcohol dehydrogenase
I6H46_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
I6H46_RS01815	COG4869	propanediol catabolic process
I6H46_RS01845	COG1162	GTPase activity
I6H46_RS01855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H46_RS01860	COG1882	Formate acetyltransferase
I6H46_RS01870	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6H46_RS01875	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6H46_RS01890	COG2816	NAD+ diphosphatase activity
I6H46_RS01895	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H46_RS01910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H46_RS01925	COG1136	(ABC) transporter
I6H46_RS01940	COG0523	cobalamin synthesis protein
I6H46_RS01955	COG2081	HI0933 family
I6H46_RS01960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H46_RS01965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H46_RS01970	COG2190	(PTS) system
I6H46_RS01970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_RS01970	COG1263	PTS System
I6H46_RS01985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H46_RS01990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6H46_RS02000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_RS02000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_RS02005	COG3585	molybdate ion transport
I6H46_RS02010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H46_RS02035	COG0644	oxidoreductase
I6H46_RS02040	COG2226	methyltransferase
I6H46_RS02060	COG1556	Lactate utilization protein
I6H46_RS02065	COG0003	Pfam Anion-transporting ATPase
I6H46_RS02075	COG1346	cytolysis
I6H46_RS02090	COG2894	cell division
I6H46_RS02115	COG1045	serine acetyltransferase
I6H46_RS02140	COG0438	transferase activity, transferring glycosyl groups
I6H46_RS02170	COG0438	transferase activity, transferring glycosyl groups
I6H46_RS02175	COG0438	transferase activity, transferring glycosyl groups
I6H46_RS02200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H46_RS02210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6H46_RS02220	COG1316	TRANSCRIPTIONal
I6H46_RS02225	COG3579	cysteine-type endopeptidase activity
I6H46_RS02245	COG1214	PFAM Peptidase M22, glycoprotease
I6H46_RS02250	COG0802	atpase or kinase
I6H46_RS02280	COG1164	Oligoendopeptidase f
I6H46_RS02285	COG2309	aminopeptidase activity
I6H46_RS02385	COG0363	glucosamine-6-phosphate deaminase activity
I6H46_RS02395	COG3830	Belongs to the UPF0237 family
I6H46_RS02405	COG0166	Belongs to the GPI family
I6H46_RS02430	COG0366	Alpha amylase catalytic
I6H46_RS02435	COG0366	Alpha amylase catalytic
I6H46_RS02440	COG0366	Alpha amylase catalytic
I6H46_RS02445	COG0366	Alpha amylase catalytic
I6H46_RS02475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H46_RS02480	COG1802	Transcriptional regulator
I6H46_RS02515	COG2222	sugar isomerase
I6H46_RS02520	COG3684	Belongs to the aldolase LacD family
I6H46_RS02525	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H46_RS02530	COG2971	BadF BadG BcrA BcrD
I6H46_RS02540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_RS02545	COG3715	PTS system
I6H46_RS02550	COG3716	PTS system mannose fructose sorbose family IID component
I6H46_RS02565	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H46_RS02565	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6H46_RS02570	COG1121	(ABC) transporter
I6H46_RS02575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H46_RS02590	COG1979	alcohol dehydrogenase
I6H46_RS02600	COG1070	Carbohydrate kinase
I6H46_RS02605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H46_RS02620	COG1349	DNA-binding transcription factor activity
I6H46_RS02625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6H46_RS02630	COG1285	pathogenesis
I6H46_RS02635	COG1115	amino acid carrier protein
I6H46_RS02640	COG0584	glycerophosphoryl diester phosphodiesterase
I6H46_RS02645	COG1253	flavin adenine dinucleotide binding
I6H46_RS02650	COG1394	ATPase activity, coupled to movement of substances
I6H46_RS02655	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I6H46_RS02665	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6H46_RS02670	COG1527	subunit (C
I6H46_RS02675	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6H46_RS02680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6H46_RS02685	COG1269	ATP hydrolysis coupled proton transport
I6H46_RS02695	COG1494	fructose-1,6-bisphosphatase
I6H46_RS02705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H46_RS02730	COG3976	FMN-binding domain protein
I6H46_RS02730	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6H46_RS02735	COG1053	succinate dehydrogenase
I6H46_RS02735	COG3976	FMN-binding domain protein
I6H46_RS02740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H46_RS02745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H46_RS02750	COG1132	(ABC) transporter
I6H46_RS02760	COG0616	signal peptide processing
I6H46_RS02765	COG1263	PTS System
I6H46_RS02765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_RS02770	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6H46_RS02780	COG1737	Transcriptional regulator
I6H46_RS02785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H46_RS02790	COG1846	Transcriptional regulator
I6H46_RS02800	COG3118	belongs to the thioredoxin family
I6H46_RS02815	COG0280	phosphate acetyltransferase
I6H46_RS02830	COG1475	DNA binding
I6H46_RS02835	COG1192	Involved in chromosome partitioning
I6H46_RS02840	COG1058	Belongs to the CinA family
I6H46_RS02840	COG1546	Belongs to the CinA family
I6H46_RS02850	COG0445	tRNA wobble uridine modification
I6H46_RS02855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H46_RS02860	COG1847	R3H domain protein
I6H46_RS02865	COG0706	membrane insertase activity
I6H46_RS02870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H46_RS02880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6H46_RS02885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6H46_RS02890	COG0592	DNA-directed DNA polymerase activity
I6H46_RS02900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H46_RS02905	COG0187	DNA topoisomerase II activity
I6H46_RS02910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H46_RS02925	COG1191	sigma factor activity
I6H46_RS02930	COG4166	transmembrane transport
I6H46_RS02935	COG0601	transmembrane transport
I6H46_RS02940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H46_RS02945	COG0444	Belongs to the ABC transporter superfamily
I6H46_RS02950	COG4608	Belongs to the ABC transporter superfamily
I6H46_RS02950	COG4608	Belongs to the ABC transporter superfamily
I6H46_RS02970	COG2314	TM2 domain
I6H46_RS02975	COG1396	sequence-specific DNA binding
I6H46_RS02975	COG3800	Transcriptional regulator
I6H46_RS02985	COG0450	alkyl hydroperoxide reductase
I6H46_RS02990	COG1929	Belongs to the glycerate kinase type-1 family
I6H46_RS02995	COG0705	Rhomboid family
I6H46_RS02995	COG0457	Tetratricopeptide repeat
I6H46_RS03000	COG1164	Oligoendopeptidase f
I6H46_RS03020	COG0785	Cytochrome C biogenesis protein
I6H46_RS03025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H46_RS03035	COG2207	Transcriptional regulator
I6H46_RS03035	COG4753	response regulator
I6H46_RS03040	COG2972	Histidine kinase
I6H46_RS03050	COG2252	PERMEase
I6H46_RS03055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6H46_RS03060	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H46_RS03060	COG1024	Enoyl-CoA hydratase
I6H46_RS03075	COG1757	Na H antiporter
I6H46_RS03080	COG0583	DNA-binding transcription factor activity
I6H46_RS03140	COG1640	4-alpha-glucanotransferase
I6H46_RS03145	COG3842	ATPase activity
I6H46_RS03150	COG0534	Mate efflux family protein
I6H46_RS03155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H46_RS03190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H46_RS03195	COG0569	domain protein
I6H46_RS03205	COG4463	regulation of RNA biosynthetic process
I6H46_RS03220	COG0542	response to heat
I6H46_RS03245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H46_RS03250	COG1121	(ABC) transporter
I6H46_RS03275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H46_RS03290	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6H46_RS03295	COG1609	Transcriptional regulator
I6H46_RS03310	COG1129	ABC transporter
I6H46_RS03315	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H46_RS03320	COG1879	ABC-type sugar transport system periplasmic component
I6H46_RS03330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_RS03335	COG3716	PTS system mannose fructose sorbose family IID component
I6H46_RS03345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H46_RS03350	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6H46_RS03355	COG1737	Transcriptional regulator
I6H46_RS03360	COG4221	oxidoreductase activity
I6H46_RS03365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H46_RS03390	COG0438	transferase activity, transferring glycosyl groups
I6H46_RS03420	COG1725	Transcriptional regulator
I6H46_RS03425	COG1131	(ABC) transporter
I6H46_RS03435	COG1482	cell wall glycoprotein biosynthetic process
I6H46_RS03455	COG4956	integral membrane protein (PIN domain superfamily)
I6H46_RS03460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6H46_RS03465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6H46_RS03470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H46_RS03475	COG1077	Cell shape determining protein MreB Mrl
I6H46_RS03480	COG0588	phosphoglycerate mutase activity
I6H46_RS03500	COG0385	Bile acid
I6H46_RS03505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6H46_RS03510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6H46_RS03545	COG1518	maintenance of DNA repeat elements
I6H46_RS03550	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6H46_RS03615	COG0464	growth
I6H46_RS03620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H46_RS03625	COG0215	cysteine-tRNA ligase activity
I6H46_RS03630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H46_RS03640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H46_RS03665	COG4152	abc transporter atp-binding protein
I6H46_RS03700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H46_RS03705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H46_RS03715	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H46_RS03720	COG0037	tRNA processing
I6H46_RS03725	COG1968	undecaprenyl-diphosphatase activity
I6H46_RS03745	COG1725	Transcriptional regulator
I6H46_RS03750	COG1129	ABC transporter
I6H46_RS03750	COG0842	Transport permease protein
I6H46_RS03760	COG0598	Magnesium transport protein CorA
I6H46_RS03800	COG1461	Dihydroxyacetone kinase
I6H46_RS03805	COG3853	Toxic anion resistance protein (TelA)
I6H46_RS03825	COG3715	PTS system
I6H46_RS03830	COG3716	PTS system mannose fructose sorbose family IID component
I6H46_RS03840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H46_RS03855	COG0668	transmembrane transport
I6H46_RS03860	COG4481	Protein conserved in bacteria
I6H46_RS03985	COG0569	domain protein
I6H46_RS03995	COG1811	Na channel or pump
I6H46_RS04000	COG0351	phosphomethylpyrimidine kinase
I6H46_RS04000	COG0352	thiamine-phosphate diphosphorylase activity
I6H46_RS04015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H46_RS04020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H46_RS04030	COG2059	Chromate
I6H46_RS04035	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H46_RS04045	COG1528	Iron-storage protein
I6H46_RS04065	COG0561	phosphatase activity
I6H46_RS04075	COG4509	Sortase family
I6H46_RS04085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6H46_RS04110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6H46_RS04115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6H46_RS04115	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6H46_RS04115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H46_RS04115	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6H46_RS04120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H46_RS04130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H46_RS04135	COG2011	ABC-type metal ion transport system permease component
I6H46_RS04150	COG0456	acetyltransferase
I6H46_RS04155	COG0210	DNA helicase
I6H46_RS04165	COG1187	pseudouridine synthase activity
I6H46_RS04170	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6H46_RS04195	COG2963	transposase activity
I6H46_RS04200	COG2801	Transposase and inactivated derivatives
I6H46_RS04215	COG0601	transmembrane transport
I6H46_RS04220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H46_RS04230	COG4608	Belongs to the ABC transporter superfamily
I6H46_RS04235	COG4166	transmembrane transport
I6H46_RS04240	COG2801	Transposase and inactivated derivatives
I6H46_RS04250	COG2963	transposase activity
I6H46_RS04275	COG1136	(ABC) transporter
I6H46_RS04290	COG0579	oxidoreductase
I6H46_RS04295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H46_RS04300	COG1363	Peptidase, m42
I6H46_RS04305	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H46_RS04310	COG3845	ABC transporter
I6H46_RS04315	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H46_RS04320	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H46_RS04350	COG1131	(ABC) transporter
I6H46_RS04370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H46_RS04385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H46_RS04390	COG1442	glycosyl transferase family 8
I6H46_RS04410	COG1217	gtp-binding protein TYPA
I6H46_RS04425	COG0488	(ABC) transporter
I6H46_RS04445	COG1393	Belongs to the ArsC family
I6H46_RS04465	COG0058	SHG alpha-glucan phosphorylase activity
I6H46_RS04475	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6H46_RS04495	COG0740	serine-type endopeptidase activity
I6H46_RS04500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6H46_RS04505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6H46_RS04510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6H46_RS04520	COG1362	aminopeptidase activity
I6H46_RS04525	COG0011	TIGRFAM Protein of
I6H46_RS04530	COG2252	PERMEase
I6H46_RS04535	COG4536	flavin adenine dinucleotide binding
I6H46_RS04545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6H46_RS04550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6H46_RS04555	COG0077	Prephenate dehydratase
I6H46_RS04555	COG1605	Chorismate mutase
I6H46_RS04565	COG1115	amino acid carrier protein
I6H46_RS04585	COG1362	aminopeptidase activity
I6H46_RS04600	COG0534	Mate efflux family protein
I6H46_RS04605	COG0351	phosphomethylpyrimidine kinase
I6H46_RS04610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H46_RS04615	COG2186	Transcriptional regulator
I6H46_RS04620	COG1131	(ABC) transporter
I6H46_RS04630	COG2131	deaminase
I6H46_RS04675	COG1131	(ABC) transporter
I6H46_RS04680	COG1131	(ABC) transporter
I6H46_RS04685	COG0051	transcription antitermination factor activity, RNA binding
I6H46_RS04690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6H46_RS04695	COG0088	Forms part of the polypeptide exit tunnel
I6H46_RS04700	COG0089	rRNA binding
I6H46_RS04705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6H46_RS04710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6H46_RS04715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6H46_RS04720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6H46_RS04725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6H46_RS04730	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H46_RS04735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6H46_RS04740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6H46_RS04745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H46_RS04750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6H46_RS04755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H46_RS04760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6H46_RS04765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6H46_RS04770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6H46_RS04775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H46_RS04780	COG1841	ribosomal large subunit assembly
I6H46_RS04785	COG0200	Binds to the 23S rRNA
I6H46_RS04795	COG0563	adenylate kinase activity
I6H46_RS04800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6H46_RS04805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6H46_RS04810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H46_RS04815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H46_RS04820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H46_RS04825	COG0202	RNA polymerase activity
I6H46_RS04830	COG0203	ribosomal protein L17
I6H46_RS04855	COG0205	6-phosphofructokinase activity
I6H46_RS04885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H46_RS04895	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H46_RS04900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6H46_RS04910	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6H46_RS04925	COG0085	RNA polymerase activity
I6H46_RS04930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H46_RS04955	COG3383	formate dehydrogenase (NAD+) activity
I6H46_RS04960	COG3383	formate dehydrogenase (NAD+) activity
I6H46_RS04975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H46_RS04985	COG0303	'Molybdopterin
I6H46_RS05000	COG1131	(ABC) transporter
I6H46_RS05010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6H46_RS05015	COG0049	tRNA binding
I6H46_RS05020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H46_RS05025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H46_RS05045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H46_RS05050	COG1971	Probably functions as a manganese efflux pump
I6H46_RS05060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H46_RS05075	COG0138	bifunctional purine biosynthesis protein purh
I6H46_RS05080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H46_RS05085	COG0517	IMP dehydrogenase activity
I6H46_RS05085	COG0516	GMP reductase activity
I6H46_RS05095	COG1346	cytolysis
I6H46_RS05100	COG1380	Effector of murein hydrolase LrgA
I6H46_RS05105	COG0277	FAD linked oxidase domain protein
I6H46_RS05110	COG1960	acyl-CoA dehydrogenase activity
I6H46_RS05120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6H46_RS05125	COG0427	acetyl-CoA hydrolase
I6H46_RS05130	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H46_RS05135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H46_RS05140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H46_RS05145	COG1876	peptidase activity
I6H46_RS05150	COG0728	peptidoglycan biosynthetic process
I6H46_RS05190	COG0410	ABC transporter
I6H46_RS05215	COG0346	lactoylglutathione lyase activity
I6H46_RS05240	COG0124	histidyl-tRNA synthetase
I6H46_RS05275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H46_RS05315	COG1307	EDD domain protein, DegV family
I6H46_RS05320	COG2033	superoxide reductase activity
I6H46_RS05325	COG0116	Belongs to the methyltransferase superfamily
I6H46_RS05340	COG1122	ATPase activity
I6H46_RS05345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H46_RS05350	COG0101	tRNA pseudouridine synthase activity
I6H46_RS05360	COG0514	ATP-dependent DNA helicase (RecQ)
I6H46_RS05375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H46_RS05380	COG0573	inorganic phosphate transmembrane transporter activity
I6H46_RS05385	COG0581	inorganic phosphate transmembrane transporter activity
I6H46_RS05390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H46_RS05395	COG0704	Plays a role in the regulation of phosphate uptake
I6H46_RS05400	COG0745	RESPONSE REGULATOR receiver
I6H46_RS05405	COG5002	protein histidine kinase activity
I6H46_RS05425	COG1960	acyl-CoA dehydrogenase activity
I6H46_RS05435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H46_RS05435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H46_RS05435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H46_RS05435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H46_RS05440	COG1408	metallophosphoesterase
I6H46_RS05475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H46_RS05480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6H46_RS05485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H46_RS05490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H46_RS05495	COG0151	Belongs to the GarS family
I6H46_RS05500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H46_RS05505	COG1301	dicarboxylic acid transport
I6H46_RS05515	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H46_RS05515	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6H46_RS05520	COG1121	(ABC) transporter
I6H46_RS05525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H46_RS05530	COG3022	response to hydroperoxide
I6H46_RS05550	COG0419	ATPase involved in DNA repair
I6H46_RS05560	COG1074	ATP-dependent DNA helicase activity
I6H46_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
I6H46_RS05570	COG0656	L-ascorbic acid biosynthetic process
I6H46_RS05580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H46_RS05600	COG0493	'glutamate synthase
I6H46_RS05610	COG1132	(ABC) transporter
I6H46_RS05615	COG0484	heat shock protein binding
I6H46_RS05630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H46_RS05630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6H46_RS05645	COG1104	cysteine desulfurase activity
I6H46_RS05650	COG0482	sulfurtransferase activity
I6H46_RS05660	COG0606	chelatase, subunit chli
I6H46_RS05665	COG0564	pseudouridine synthase activity
I6H46_RS05675	COG4589	Belongs to the CDS family
I6H46_RS05680	COG0750	zinc metalloprotease
I6H46_RS05685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6H46_RS05695	COG0697	spore germination
I6H46_RS05700	COG0779	Required for maturation of 30S ribosomal subunits
I6H46_RS05705	COG0195	Participates in both transcription termination and antitermination
I6H46_RS05710	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H46_RS05720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H46_RS05725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H46_RS05730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H46_RS05735	COG0196	riboflavin kinase activity
I6H46_RS05745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6H46_RS05750	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H46_RS05760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H46_RS05765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6H46_RS05770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H46_RS05775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H46_RS05785	COG0037	tRNA processing
I6H46_RS05790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6H46_RS05800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6H46_RS05805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H46_RS05810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H46_RS05815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H46_RS05830	COG1484	DNA-dependent DNA replication
I6H46_RS05865	COG1132	(ABC) transporter
I6H46_RS05870	COG1132	(ABC) transporter
I6H46_RS05875	COG1129	ABC transporter
I6H46_RS05990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H46_RS05990	COG0551	DNA topoisomerase type I activity
I6H46_RS06020	COG0745	RESPONSE REGULATOR receiver
I6H46_RS06025	COG2205	protein histidine kinase activity
I6H46_RS06065	COG0577	efflux transmembrane transporter activity
I6H46_RS06065	COG1136	(ABC) transporter
I6H46_RS06200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H46_RS06215	COG4555	ABC transporter
I6H46_RS06260	COG2091	lysine biosynthetic process via aminoadipic acid
I6H46_RS06265	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6H46_RS06305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H46_RS06305	COG3433	isochorismatase activity
I6H46_RS06305	COG2226	methyltransferase
I6H46_RS06385	COG2226	methyltransferase
I6H46_RS06385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H46_RS06385	COG3433	isochorismatase activity
I6H46_RS06480	COG0534	Mate efflux family protein
I6H46_RS06515	COG1136	(ABC) transporter
I6H46_RS06520	COG1136	(ABC) transporter
I6H46_RS06550	COG1136	(ABC) transporter
I6H46_RS06560	COG3843	relaxase mobilization nuclease domain protein
I6H46_RS06595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_RS06595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H46_RS06615	COG1131	(ABC) transporter
I6H46_RS06630	COG0745	RESPONSE REGULATOR receiver
I6H46_RS06635	COG5002	protein histidine kinase activity
I6H46_RS06690	COG2094	Belongs to the DNA glycosylase MPG family
I6H46_RS06695	COG1597	lipid kinase activity
I6H46_RS06705	COG0733	neurotransmitter:sodium symporter activity
I6H46_RS06710	COG0733	neurotransmitter:sodium symporter activity
I6H46_RS06715	COG2843	Capsule synthesis protein
I6H46_RS06720	COG0671	phosphoesterase, PA-phosphatase related
I6H46_RS06735	COG0237	dephospho-CoA kinase activity
I6H46_RS06740	COG0741	lytic transglycosylase activity
I6H46_RS06745	COG4656	Part of a membrane complex involved in electron transport
I6H46_RS06750	COG4658	electron transport chain
I6H46_RS06760	COG4660	Part of a membrane complex involved in electron transport
I6H46_RS06765	COG4657	Part of a membrane complex involved in electron transport
I6H46_RS06770	COG2878	Part of a membrane complex involved in electron transport
I6H46_RS06770	COG1245	4Fe-4S binding domain
I6H46_RS06785	COG2003	Belongs to the UPF0758 family
I6H46_RS06795	COG1792	Involved in formation and maintenance of cell shape
I6H46_RS06805	COG0768	penicillin binding
I6H46_RS06815	COG1530	ribonuclease E activity
I6H46_RS06825	COG2137	regulation of response to DNA damage stimulus
I6H46_RS06860	COG0233	cytoplasmic translational termination
I6H46_RS06865	COG1459	type II secretion system
I6H46_RS06900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H46_RS06905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6H46_RS06910	COG0416	fatty acid biosynthetic process
I6H46_RS06915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H46_RS06920	COG0571	ribonuclease III activity
I6H46_RS06935	COG0242	peptide deformylase activity
I6H46_RS06940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6H46_RS06945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H46_RS06945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H46_RS06950	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H46_RS06960	COG0515	serine threonine protein kinase
I6H46_RS06960	COG2815	serine threonine protein kinase
I6H46_RS06970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H46_RS06975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H46_RS06980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H46_RS06985	COG1660	Displays ATPase and GTPase activities
I6H46_RS06995	COG1481	regulation of sporulation
I6H46_RS07000	COG0587	DNA-directed DNA polymerase activity
I6H46_RS07005	COG0205	6-phosphofructokinase activity
I6H46_RS07015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H46_RS07095	COG0745	RESPONSE REGULATOR receiver
I6H46_RS07105	COG0577	efflux transmembrane transporter activity
I6H46_RS07105	COG1136	(ABC) transporter
I6H46_RS07115	COG0433	COG0433 Predicted ATPase
I6H46_RS07130	COG1132	(ABC) transporter
I6H46_RS07135	COG1132	(ABC) transporter
I6H46_RS07150	COG1129	ABC transporter
I6H46_RS07210	COG0484	heat shock protein binding
I6H46_RS07225	COG0602	queuosine metabolic process
I6H46_RS07260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H46_RS07295	COG1309	transcriptional regulator
I6H46_RS07310	COG0444	Belongs to the ABC transporter superfamily
I6H46_RS07315	COG4608	Belongs to the ABC transporter superfamily
I6H46_RS07320	COG0747	negative chemotaxis
I6H46_RS07325	COG1132	(ABC) transporter
I6H46_RS07325	COG2375	cellular response to nickel ion
I6H46_RS07330	COG1132	(ABC) transporter
I6H46_RS07365	COG2190	(PTS) system
I6H46_RS07365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H46_RS07365	COG1263	PTS System
I6H46_RS07375	COG2188	Transcriptional regulator
I6H46_RS07390	COG1395	domain, Protein
I6H46_RS07410	COG1401	restriction endodeoxyribonuclease activity
I6H46_RS07555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H46_RS07555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H46_RS07560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6H46_RS07575	COG0716	FMN binding
I6H46_RS07580	COG2376	Dihydroxyacetone kinase
I6H46_RS07595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6H46_RS07600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H46_RS07605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H46_RS07615	COG0398	Pfam SNARE associated Golgi protein
I6H46_RS07640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H46_RS07650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H46_RS07655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6H46_RS07665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6H46_RS07670	COG0081	regulation of translation
I6H46_RS07675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6H46_RS07680	COG0222	ribosome binding
I6H46_RS07695	COG0285	dihydrofolate synthase activity
I6H46_RS07700	COG1288	antiporter activity
I6H46_RS07705	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H46_RS07710	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H46_RS07715	COG2801	Transposase and inactivated derivatives
I6H46_RS07725	COG2963	transposase activity
I6H46_RS07735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H46_RS07740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H46_RS07745	COG0297	glycogen (starch) synthase activity
I6H46_RS07750	COG0058	SHG alpha-glucan phosphorylase activity
I6H46_RS07755	COG1523	belongs to the glycosyl hydrolase 13 family
I6H46_RS07760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H46_RS07770	COG0772	Belongs to the SEDS family
I6H46_RS07775	COG0768	penicillin binding
I6H46_RS07780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H46_RS07785	COG0564	pseudouridine synthase activity
I6H46_RS07805	COG1609	Transcriptional regulator
I6H46_RS07815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H46_RS07825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H46_RS07835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H46_RS07865	COG0564	pseudouridine synthase activity
I6H46_RS07870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H46_RS07880	COG0745	RESPONSE REGULATOR receiver
I6H46_RS07885	COG5002	protein histidine kinase activity
I6H46_RS07895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6H46_RS07920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6H46_RS07925	COG0632	four-way junction helicase activity
I6H46_RS07930	COG2255	four-way junction helicase activity
I6H46_RS07940	COG0343	queuine tRNA-ribosyltransferase activity
I6H46_RS07950	COG1115	amino acid carrier protein
I6H46_RS07955	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H46_RS07955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H46_RS07960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H46_RS07975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6H46_RS07985	COG1160	GTP binding
I6H46_RS07990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6H46_RS08000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H46_RS08005	COG1799	cell septum assembly
I6H46_RS08030	COG1104	cysteine desulfurase activity
I6H46_RS08035	COG0301	tRNA thio-modification
I6H46_RS08040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6H46_RS08045	COG2868	ribosomal protein
I6H46_RS08050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H46_RS08055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6H46_RS08060	COG1534	Rna-binding protein
I6H46_RS08065	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H46_RS08070	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H46_RS08075	COG0799	negative regulation of ribosome biogenesis
I6H46_RS08080	COG1596	polysaccharide export
I6H46_RS08080	COG1555	photosystem II stabilization
I6H46_RS08085	COG1959	2 iron, 2 sulfur cluster binding
I6H46_RS08090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H46_RS08095	COG4472	Bacterial protein of unknown function (DUF965)
I6H46_RS08100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H46_RS08115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6H46_RS08120	COG4122	O-methyltransferase activity
I6H46_RS08125	COG0826	peptidase U32
I6H46_RS08140	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H46_RS08145	COG0756	dUTP diphosphatase activity
I6H46_RS08155	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6H46_RS08160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H46_RS08165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6H46_RS08170	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6H46_RS08175	COG4974	Belongs to the 'phage' integrase family
I6H46_RS08180	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H46_RS08180	COG1388	LysM domain
I6H46_RS08195	COG1418	mRNA catabolic process
I6H46_RS08200	COG1132	(ABC) transporter
I6H46_RS08205	COG1132	(ABC) transporter
I6H46_RS08210	COG1045	serine acetyltransferase
I6H46_RS08215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H46_RS08220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H46_RS08225	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H46_RS08230	COG0552	protein localization to endoplasmic reticulum
I6H46_RS08235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H46_RS08240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H46_RS08245	COG1758	RNA polymerase activity
I6H46_RS08250	COG0194	GDP metabolic process
I6H46_RS08260	COG0776	regulation of translation
I6H46_RS08270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H46_RS08275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H46_RS08280	COG0193	aminoacyl-tRNA hydrolase activity
I6H46_RS08290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H46_RS08300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H46_RS08305	COG0698	ribose 5-phosphate isomerase
I6H46_RS08320	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6H46_RS08325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H46_RS08330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H46_RS08330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H46_RS08335	COG0402	S-adenosylhomocysteine deaminase activity
I6H46_RS08340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H46_RS08350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H46_RS08355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H46_RS08360	COG0210	DNA helicase
I6H46_RS08365	COG4496	protein, YerC YecD
I6H46_RS08370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6H46_RS08375	COG3442	glutamine amidotransferase
I6H46_RS08380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H46_RS08390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6H46_RS08395	COG0167	dihydroorotate dehydrogenase activity
I6H46_RS08400	COG0543	2 iron, 2 sulfur cluster binding
I6H46_RS08405	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H46_RS08420	COG0540	Belongs to the ATCase OTCase family
I6H46_RS08445	COG0588	phosphoglycerate mutase activity
I6H46_RS08455	COG1136	(ABC) transporter
I6H46_RS08460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H46_RS08465	COG0557	exoribonuclease II activity
I6H46_RS08475	COG0148	phosphopyruvate hydratase activity
I6H46_RS08480	COG0149	triose-phosphate isomerase activity
I6H46_RS08485	COG0126	phosphoglycerate kinase activity
I6H46_RS08500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H46_RS08505	COG0561	phosphatase activity
I6H46_RS08510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H46_RS08515	COG0772	Belongs to the SEDS family
I6H46_RS08520	COG4475	Protein of unknown function (DUF436)
I6H46_RS08555	COG1269	ATP hydrolysis coupled proton transport
I6H46_RS08570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H46_RS08575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6H46_RS08575	COG0539	negative regulation of cytoplasmic translation
I6H46_RS08580	COG0204	Acyl-transferase
I6H46_RS08585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H46_RS08590	COG2081	HI0933 family
I6H46_RS08595	COG1187	pseudouridine synthase activity
I6H46_RS08600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H46_RS08610	COG1051	belongs to the nudix hydrolase family
I6H46_RS08615	COG0497	DNA recombination
I6H46_RS08620	COG1438	arginine binding
I6H46_RS08640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H46_RS08650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H46_RS08655	COG1323	Belongs to the UPF0348 family
I6H46_RS08670	COG0742	ribosomal rna small subunit methyltransferase
I6H46_RS08690	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6H46_RS08690	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6H46_RS08690	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6H46_RS08690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H46_RS08700	COG0322	excinuclease ABC activity
I6H46_RS08705	COG0006	proline dipeptidase activity
I6H46_RS08710	COG0012	GTP binding
I6H46_RS08720	COG0183	Belongs to the thiolase family
I6H46_RS08725	COG1114	Component of the transport system for branched-chain amino acids
I6H46_RS08730	COG0024	Methionine aminopeptidase
I6H46_RS08735	COG0778	Nitroreductase
I6H46_RS08740	COG0210	DNA helicase
I6H46_RS08745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6H46_RS08755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H46_RS08760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6H46_RS08765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H46_RS08785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H46_RS08790	COG2207	Transcriptional regulator
I6H46_RS08790	COG1917	Cupin 2, conserved barrel domain protein
I6H46_RS08805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6H46_RS08825	COG1774	PSP1 C-terminal conserved region
I6H46_RS08835	COG3870	Protein conserved in bacteria
I6H46_RS08840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6H46_RS08845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6H46_RS08850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6H46_RS08860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6H46_RS08875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H46_RS08880	COG2384	SAM-dependent methyltransferase
I6H46_RS08885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H46_RS08885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H46_RS08890	COG0358	DNA primase activity
I6H46_RS08895	COG1012	belongs to the aldehyde dehydrogenase family
I6H46_RS08900	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H46_RS08905	COG1950	PFAM Membrane protein of
I6H46_RS08910	COG1254	Belongs to the acylphosphatase family
I6H46_RS08915	COG2217	Heavy metal translocating P-type atpase
I6H46_RS08950	COG0039	L-malate dehydrogenase activity
I6H46_RS08955	COG0494	nUDIX hydrolase
I6H46_RS08975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H46_RS08990	COG5522	Integral membrane protein (intg_mem_TP0381)
I6H46_RS09015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6H46_RS09020	COG0537	adenosine 5'-monophosphoramidase activity
I6H46_RS09025	COG1114	Component of the transport system for branched-chain amino acids
I6H46_RS09040	COG1597	lipid kinase activity
I6H46_RS09045	COG0708	Exodeoxyribonuclease III
I6H46_RS09050	COG2321	neutral zinc metallopeptidase
I6H46_RS09055	COG0640	Transcriptional regulator
I6H46_RS09065	COG2217	Heavy metal translocating P-type atpase
I6H46_RS09075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6H46_RS09090	COG1115	amino acid carrier protein
I6H46_RS09095	COG1757	Na H antiporter
I6H46_RS09100	COG1115	amino acid carrier protein
I6H46_RS09110	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6H46_RS09130	COG1757	Na H antiporter
I6H46_RS09140	COG1132	(ABC) transporter
I6H46_RS09175	COG1316	TRANSCRIPTIONal
I6H46_RS09190	COG1982	Orn Lys Arg decarboxylase major
I6H46_RS09210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H46_RS09215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H46_RS09220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6H46_RS09225	COG0009	L-threonylcarbamoyladenylate synthase
I6H46_RS09230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H46_RS09235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H46_RS09240	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H46_RS09245	COG0254	rRNA binding
I6H46_RS09255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6H46_RS09270	COG0442	prolyl-tRNA aminoacylation
I6H46_RS09275	COG2190	(PTS) system
I6H46_RS09280	COG2183	response to ionizing radiation
I6H46_RS09300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6H46_RS09305	COG0484	heat shock protein binding
I6H46_RS09310	COG0443	Heat shock 70 kDa protein
I6H46_RS09315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H46_RS09320	COG1420	regulation of RNA biosynthetic process
I6H46_RS09325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H46_RS09330	COG0481	GTPase activity
I6H46_RS09335	COG0681	Belongs to the peptidase S26 family
I6H46_RS09340	COG0268	Binds directly to 16S ribosomal RNA
I6H46_RS09350	COG0658	competence protein
I6H46_RS09350	COG2333	competence protein COMEC
I6H46_RS09360	COG0495	leucyl-tRNA aminoacylation
I6H46_RS09370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H46_RS09375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H46_RS09380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H46_RS09390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6H46_RS09395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6H46_RS09400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H46_RS09410	COG0275	rRNA processing
I6H46_RS09415	COG2001	Belongs to the MraZ family
I6H46_RS09420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6H46_RS09425	COG0217	transcriptional regulatory protein
I6H46_RS09430	COG1739	Uncharacterized protein family UPF0029
I6H46_RS09435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H46_RS09445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H46_RS09460	COG0745	RESPONSE REGULATOR receiver
I6H46_RS09465	COG5002	protein histidine kinase activity
I6H46_RS09485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H46_RS09490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H46_RS09505	COG0235	Class ii aldolase
I6H46_RS09515	COG3037	sugar-specific permease SgaT UlaA
I6H46_RS09520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system