locus-tag	class	description
APRE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APRE_RS00010	COG0592	DNA-directed DNA polymerase activity
APRE_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APRE_RS00025	COG0187	DNA topoisomerase II activity
APRE_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APRE_RS00035	COG1366	Belongs to the anti-sigma-factor antagonist family
APRE_RS00045	COG1191	sigma factor activity
APRE_RS00070	COG4166	transmembrane transport
APRE_RS00075	COG4166	transmembrane transport
APRE_RS00080	COG0601	transmembrane transport
APRE_RS00085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APRE_RS00090	COG0444	Belongs to the ABC transporter superfamily
APRE_RS00095	COG4608	Belongs to the ABC transporter superfamily
APRE_RS00105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APRE_RS00135	COG3708	Transcriptional regulator
APRE_RS00135	COG2207	Transcriptional regulator
APRE_RS00140	COG1115	amino acid carrier protein
APRE_RS00150	COG0542	response to heat
APRE_RS00155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APRE_RS00175	COG1349	DNA-binding transcription factor activity
APRE_RS00185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
APRE_RS00190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APRE_RS00205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APRE_RS00215	COG4120	Belongs to the binding-protein-dependent transport system permease family
APRE_RS00220	COG3842	ATPase activity
APRE_RS00235	COG3634	alkyl hydroperoxide reductase activity
APRE_RS00240	COG0450	alkyl hydroperoxide reductase
APRE_RS00260	COG1176	ABC-type spermidine putrescine transport system, permease component I
APRE_RS00265	COG3842	ATPase activity
APRE_RS00275	COG1929	Belongs to the glycerate kinase type-1 family
APRE_RS00280	COG0705	Rhomboid family
APRE_RS00280	COG0457	Tetratricopeptide repeat
APRE_RS00290	COG1164	Oligoendopeptidase f
APRE_RS00300	COG0584	glycerophosphoryl diester phosphodiesterase
APRE_RS00310	COG1175	transmembrane transport
APRE_RS00315	COG0395	ABC-type sugar transport system, permease component
APRE_RS00320	COG3842	ATPase activity
APRE_RS00370	COG0698	ribose 5-phosphate isomerase
APRE_RS00375	COG2211	Major facilitator Superfamily
APRE_RS00385	COG1349	DNA-binding transcription factor activity
APRE_RS00395	COG2222	sugar isomerase
APRE_RS00400	COG2188	Transcriptional regulator
APRE_RS00410	COG1105	Belongs to the carbohydrate kinase PfkB family
APRE_RS00415	COG3684	Belongs to the aldolase LacD family
APRE_RS00425	COG1960	acyl-CoA dehydrogenase activity
APRE_RS00435	COG1263	PTS System
APRE_RS00435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APRE_RS00450	COG0745	RESPONSE REGULATOR receiver
APRE_RS00455	COG5002	protein histidine kinase activity
APRE_RS00470	COG0366	Alpha amylase catalytic
APRE_RS00470	COG5263	repeat protein
APRE_RS00475	COG1027	Aspartate ammonia-lyase
APRE_RS00480	COG0114	fumarate hydratase activity
APRE_RS00495	COG1301	dicarboxylic acid transport
APRE_RS00510	COG1115	amino acid carrier protein
APRE_RS00520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APRE_RS00545	COG0598	Magnesium transport protein CorA
APRE_RS00560	COG1363	Peptidase, m42
APRE_RS00565	COG4894	glucomannan catabolic process
APRE_RS00570	COG1609	Transcriptional regulator
APRE_RS00585	COG3243	poly(R)-hydroxyalkanoic acid synthase
APRE_RS00590	COG2030	dehydratase
APRE_RS00595	COG0385	Bile acid
APRE_RS00600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APRE_RS00605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APRE_RS00620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APRE_RS00625	COG0569	domain protein
APRE_RS00630	COG2738	Putative neutral zinc metallopeptidase
APRE_RS00635	COG4463	regulation of RNA biosynthetic process
APRE_RS00640	COG3880	PFAM UvrB UvrC protein
APRE_RS00645	COG3869	Catalyzes the specific phosphorylation of arginine residues in
APRE_RS00650	COG0542	response to heat
APRE_RS00670	COG1175	transmembrane transport
APRE_RS00675	COG3833	ABC-type maltose transport systems, permease component
APRE_RS00680	COG3842	ATPase activity
APRE_RS00685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APRE_RS00695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APRE_RS00715	COG3579	cysteine-type endopeptidase activity
APRE_RS00720	COG1482	cell wall glycoprotein biosynthetic process
APRE_RS00725	COG3842	ATPase activity
APRE_RS00735	COG4209	transmembrane transport
APRE_RS00740	COG0395	ABC-type sugar transport system, permease component
APRE_RS00755	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APRE_RS00755	COG3291	Pkd domain containing protein
APRE_RS00760	COG0383	alpha-mannosidase activity
APRE_RS00780	COG2723	6-phospho-beta-galactosidase activity
APRE_RS00785	COG1940	carbohydrate kinase activity
APRE_RS00790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APRE_RS00795	COG0546	phosphoglycolate phosphatase activity
APRE_RS00810	COG0438	transferase activity, transferring glycosyl groups
APRE_RS00850	COG3859	Proton-coupled thiamine transporter YuaJ
APRE_RS00860	COG1131	(ABC) transporter
APRE_RS00870	COG1131	(ABC) transporter
APRE_RS00880	COG1597	lipid kinase activity
APRE_RS00890	COG4956	integral membrane protein (PIN domain superfamily)
APRE_RS00895	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APRE_RS00905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APRE_RS00910	COG1077	Cell shape determining protein MreB Mrl
APRE_RS00930	COG0802	atpase or kinase
APRE_RS00935	COG1214	PFAM Peptidase M22, glycoprotease
APRE_RS00940	COG0456	acetyltransferase
APRE_RS00940	COG1846	Transcriptional regulator
APRE_RS00945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APRE_RS00965	COG1316	TRANSCRIPTIONal
APRE_RS00970	COG1304	FMN binding
APRE_RS00975	COG1725	Transcriptional regulator
APRE_RS00980	COG1131	(ABC) transporter
APRE_RS00990	COG1461	Dihydroxyacetone kinase
APRE_RS01015	COG0673	inositol 2-dehydrogenase activity
APRE_RS01025	COG3715	PTS system
APRE_RS01030	COG3716	PTS system mannose fructose sorbose family IID component
APRE_RS01045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APRE_RS01055	COG0668	transmembrane transport
APRE_RS01060	COG4481	Protein conserved in bacteria
APRE_RS01200	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
APRE_RS01210	COG1132	(ABC) transporter
APRE_RS01215	COG0561	phosphatase activity
APRE_RS01220	COG0561	phosphatase activity
APRE_RS01225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APRE_RS01225	COG1263	PTS System
APRE_RS01225	COG2190	(PTS) system
APRE_RS01230	COG1151	hydroxylamine reductase activity
APRE_RS01235	COG1473	amidohydrolase
APRE_RS01255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APRE_RS01270	COG4152	abc transporter atp-binding protein
APRE_RS01275	COG1668	transmembrane transport
APRE_RS01280	COG0281	malic enzyme
APRE_RS01290	COG0561	phosphatase activity
APRE_RS01295	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APRE_RS01300	COG0037	tRNA processing
APRE_RS01305	COG1968	undecaprenyl-diphosphatase activity
APRE_RS01310	COG0519	Catalyzes the synthesis of GMP from XMP
APRE_RS01315	COG2207	Transcriptional regulator
APRE_RS01320	COG3345	alpha-galactosidase
APRE_RS01325	COG1653	transport
APRE_RS01330	COG1175	transmembrane transport
APRE_RS01335	COG0395	ABC-type sugar transport system, permease component
APRE_RS01340	COG0366	Alpha amylase catalytic
APRE_RS01345	COG3842	ATPase activity
APRE_RS01350	COG0366	Alpha amylase catalytic
APRE_RS01355	COG0786	glutamate:sodium symporter activity
APRE_RS01360	COG1216	Glycosyl transferase, family 2
APRE_RS01395	COG3842	ATPase activity
APRE_RS01400	COG1175	transmembrane transport
APRE_RS01405	COG0395	ABC-type sugar transport system, permease component
APRE_RS01410	COG1653	transport
APRE_RS01425	COG2235	arginine
APRE_RS01470	COG2239	Acts as a magnesium transporter
APRE_RS01490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APRE_RS01495	COG1160	GTP binding
APRE_RS01505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APRE_RS01510	COG2011	ABC-type metal ion transport system permease component
APRE_RS01515	COG1464	Belongs to the NlpA lipoprotein family
APRE_RS01520	COG1464	Belongs to the NlpA lipoprotein family
APRE_RS01530	COG1301	dicarboxylic acid transport
APRE_RS01540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
APRE_RS01545	COG2873	o-acetylhomoserine
APRE_RS01550	COG0386	Belongs to the glutathione peroxidase family
APRE_RS01560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APRE_RS01565	COG1051	belongs to the nudix hydrolase family
APRE_RS01575	COG1136	(ABC) transporter
APRE_RS01575	COG0577	efflux transmembrane transporter activity
APRE_RS01585	COG0577	efflux transmembrane transporter activity
APRE_RS01585	COG1136	(ABC) transporter
APRE_RS01595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APRE_RS01605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APRE_RS01610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APRE_RS01615	COG1744	ABC transporter substrate-binding protein PnrA-like
APRE_RS01620	COG3845	ABC transporter
APRE_RS01625	COG4603	Belongs to the binding-protein-dependent transport system permease family
APRE_RS01630	COG1079	Belongs to the binding-protein-dependent transport system permease family
APRE_RS01715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APRE_RS01720	COG2195	Cleaves the N-terminal amino acid of tripeptides
APRE_RS01725	COG1924	4 iron, 4 sulfur cluster binding
APRE_RS01735	COG1687	branched-chain amino acid
APRE_RS01740	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APRE_RS01775	COG4864	UPF0365 protein
APRE_RS01785	COG1702	phosphate starvation-inducible protein PhoH
APRE_RS01790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APRE_RS01795	COG0295	cytidine deaminase activity
APRE_RS01800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APRE_RS01805	COG1381	Involved in DNA repair and RecF pathway recombination
APRE_RS01810	COG0752	glycyl-tRNA synthetase alpha subunit
APRE_RS01815	COG0751	glycine-tRNA ligase activity
APRE_RS01820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APRE_RS01825	COG0519	Catalyzes the synthesis of GMP from XMP
APRE_RS01840	COG3328	transposase activity
APRE_RS01870	COG2855	membrane
APRE_RS01875	COG0583	DNA-binding transcription factor activity
APRE_RS01885	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APRE_RS01890	COG3421	Type III restriction
APRE_RS01900	COG0433	COG0433 Predicted ATPase
APRE_RS01910	COG0542	response to heat
APRE_RS01930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APRE_RS01935	COG0798	PFAM Bile acid sodium symporter
APRE_RS01960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APRE_RS01960	COG3608	succinylglutamate desuccinylase aspartoacylase
APRE_RS01965	COG3608	succinylglutamate desuccinylase aspartoacylase
APRE_RS01965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APRE_RS01975	COG0346	lactoylglutathione lyase activity
APRE_RS01980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APRE_RS01995	COG0709	Synthesizes selenophosphate from selenide and ATP
APRE_RS02000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APRE_RS02010	COG0617	tRNA 3'-terminal CCA addition
APRE_RS02015	COG0544	peptidyl-prolyl cis-trans isomerase activity
APRE_RS02020	COG0740	serine-type endopeptidase activity
APRE_RS02025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APRE_RS02030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APRE_RS02035	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APRE_RS02040	COG3976	FMN-binding domain protein
APRE_RS02040	COG1053	succinate dehydrogenase
APRE_RS02055	COG1349	DNA-binding transcription factor activity
APRE_RS02060	COG1105	Belongs to the carbohydrate kinase PfkB family
APRE_RS02065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APRE_RS02065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APRE_RS02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APRE_RS02075	COG1362	aminopeptidase activity
APRE_RS02080	COG0011	TIGRFAM Protein of
APRE_RS02095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APRE_RS02100	COG0444	Belongs to the ABC transporter superfamily
APRE_RS02105	COG4608	Belongs to the ABC transporter superfamily
APRE_RS02115	COG2252	PERMEase
APRE_RS02120	COG4536	flavin adenine dinucleotide binding
APRE_RS02130	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
APRE_RS02135	COG1301	dicarboxylic acid transport
APRE_RS02160	COG1362	aminopeptidase activity
APRE_RS02170	COG0613	PHP domain protein
APRE_RS02185	COG1131	(ABC) transporter
APRE_RS02205	COG0628	permease
APRE_RS02220	COG0058	SHG alpha-glucan phosphorylase activity
APRE_RS02235	COG1132	(ABC) transporter
APRE_RS02255	COG3328	transposase activity
APRE_RS02275	COG0534	Mate efflux family protein
APRE_RS02285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APRE_RS02290	COG1725	Transcriptional regulator
APRE_RS02295	COG1131	(ABC) transporter
APRE_RS02305	COG2131	deaminase
APRE_RS02310	COG0561	phosphatase activity
APRE_RS02315	COG1105	Belongs to the carbohydrate kinase PfkB family
APRE_RS02320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APRE_RS02325	COG1181	Belongs to the D-alanine--D-alanine ligase family
APRE_RS02340	COG2848	UPF0210 protein
APRE_RS02345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APRE_RS02355	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
APRE_RS02370	COG0085	RNA polymerase activity
APRE_RS02375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APRE_RS02395	COG0534	Mate efflux family protein
APRE_RS02400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APRE_RS02405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APRE_RS02405	COG1263	PTS System
APRE_RS02410	COG1486	melibiose metabolic process
APRE_RS02420	COG1737	Transcriptional regulator
APRE_RS02425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APRE_RS02430	COG0049	tRNA binding
APRE_RS02435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APRE_RS02440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APRE_RS02445	COG0803	Belongs to the bacterial solute-binding protein 9 family
APRE_RS02445	COG3443	Belongs to the bacterial solute-binding protein 9 family
APRE_RS02450	COG1121	(ABC) transporter
APRE_RS02455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APRE_RS02465	COG0601	transmembrane transport
APRE_RS02470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APRE_RS02475	COG0444	Belongs to the ABC transporter superfamily
APRE_RS02480	COG4608	Belongs to the ABC transporter superfamily
APRE_RS02485	COG4166	transmembrane transport
APRE_RS02505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APRE_RS02505	COG1263	PTS System
APRE_RS02510	COG0366	Alpha amylase catalytic
APRE_RS02530	COG1136	(ABC) transporter
APRE_RS02535	COG0366	Alpha amylase catalytic
APRE_RS02555	COG0360	Binds together with S18 to 16S ribosomal RNA
APRE_RS02560	COG0629	single-stranded DNA binding
APRE_RS02565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APRE_RS02575	COG0137	argininosuccinate synthase activity
APRE_RS02580	COG0165	Argininosuccinate lyase
APRE_RS02585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APRE_RS02600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APRE_RS02605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APRE_RS02610	COG0248	Ppx GppA phosphatase
APRE_RS02615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APRE_RS02620	COG1876	peptidase activity
APRE_RS02635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APRE_RS02645	COG0803	Belongs to the bacterial solute-binding protein 9 family
APRE_RS02650	COG1121	(ABC) transporter
APRE_RS02655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APRE_RS02660	COG1012	belongs to the aldehyde dehydrogenase family
APRE_RS02670	COG1960	acyl-CoA dehydrogenase activity
APRE_RS02680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APRE_RS02680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APRE_RS02685	COG1408	metallophosphoesterase
APRE_RS02695	COG1301	dicarboxylic acid transport
APRE_RS02725	COG0803	Belongs to the bacterial solute-binding protein 9 family
APRE_RS02730	COG1121	(ABC) transporter
APRE_RS02735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APRE_RS02755	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
APRE_RS02760	COG1074	ATP-dependent DNA helicase activity
APRE_RS02790	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APRE_RS02795	COG1333	cytochrome c biogenesis protein
APRE_RS02820	COG0305	Participates in initiation and elongation during chromosome replication
APRE_RS02835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APRE_RS02840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APRE_RS02850	COG0489	protein tyrosine kinase activity
APRE_RS02855	COG4464	protein tyrosine phosphatase activity
APRE_RS02865	COG0300	oxidoreductase activity
APRE_RS02870	COG0656	L-ascorbic acid biosynthetic process
APRE_RS02875	COG0753	catalase activity
APRE_RS02880	COG1309	transcriptional regulator
APRE_RS02885	COG1033	growth of symbiont in host cell
APRE_RS02885	COG2409	Drug exporters of the RND superfamily
APRE_RS02895	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APRE_RS02895	COG0493	'glutamate synthase
APRE_RS02905	COG1132	(ABC) transporter
APRE_RS02910	COG0484	heat shock protein binding
APRE_RS02925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APRE_RS02925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APRE_RS02960	COG3682	Transcriptional regulator
APRE_RS02965	COG2217	Heavy metal translocating P-type atpase
APRE_RS02980	COG1104	cysteine desulfurase activity
APRE_RS02985	COG0482	sulfurtransferase activity
APRE_RS03055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APRE_RS03060	COG0708	Exodeoxyribonuclease III
APRE_RS03065	COG0564	pseudouridine synthase activity
APRE_RS03070	COG0606	chelatase, subunit chli
APRE_RS03075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APRE_RS03105	COG1395	domain, Protein
APRE_RS03125	COG4589	Belongs to the CDS family
APRE_RS03130	COG0750	zinc metalloprotease
APRE_RS03175	COG1966	Carbon starvation protein
APRE_RS03180	COG0779	Required for maturation of 30S ribosomal subunits
APRE_RS03185	COG0195	Participates in both transcription termination and antitermination
APRE_RS03195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APRE_RS03200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APRE_RS03205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APRE_RS03210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APRE_RS03215	COG0196	riboflavin kinase activity
APRE_RS03220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APRE_RS03225	COG1185	polyribonucleotide nucleotidyltransferase activity
APRE_RS03230	COG1674	ftsk spoiiie
APRE_RS03235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APRE_RS03240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APRE_RS03245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APRE_RS03250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APRE_RS03260	COG0037	tRNA processing
APRE_RS03265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APRE_RS03275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APRE_RS03280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APRE_RS03285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APRE_RS03290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APRE_RS03305	COG1597	lipid kinase activity
APRE_RS03335	COG0671	phosphoesterase, PA-phosphatase related
APRE_RS03360	COG0745	RESPONSE REGULATOR receiver
APRE_RS03365	COG2205	protein histidine kinase activity
APRE_RS03370	COG0534	Mate efflux family protein
APRE_RS03375	COG0528	UMP kinase activity
APRE_RS03380	COG0233	cytoplasmic translational termination
APRE_RS03385	COG1459	type II secretion system
APRE_RS03395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APRE_RS03420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APRE_RS03425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APRE_RS03435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APRE_RS03440	COG0571	ribonuclease III activity
APRE_RS03455	COG0242	peptide deformylase activity
APRE_RS03460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APRE_RS03465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APRE_RS03465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APRE_RS03470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APRE_RS03480	COG0515	serine threonine protein kinase
APRE_RS03480	COG2815	serine threonine protein kinase
APRE_RS03485	COG1162	GTPase activity
APRE_RS03490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APRE_RS03495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APRE_RS03500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APRE_RS03515	COG1481	regulation of sporulation
APRE_RS03525	COG0205	6-phosphofructokinase activity
APRE_RS03535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APRE_RS03565	COG1309	transcriptional regulator
APRE_RS03580	COG0444	Belongs to the ABC transporter superfamily
APRE_RS03585	COG4608	Belongs to the ABC transporter superfamily
APRE_RS03590	COG0747	negative chemotaxis
APRE_RS03595	COG2375	cellular response to nickel ion
APRE_RS03595	COG1132	(ABC) transporter
APRE_RS03600	COG1132	(ABC) transporter
APRE_RS03610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APRE_RS03640	COG0803	Belongs to the bacterial solute-binding protein 9 family
APRE_RS03645	COG1121	(ABC) transporter
APRE_RS03650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APRE_RS03650	COG1321	iron dependent repressor
APRE_RS03655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APRE_RS03670	COG1132	(ABC) transporter
APRE_RS03675	COG1132	(ABC) transporter
APRE_RS03740	COG0830	nickel cation binding
APRE_RS03745	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APRE_RS03750	COG0829	nickel cation binding
APRE_RS03755	COG0831	urea catabolic process
APRE_RS03760	COG0831	urea catabolic process
APRE_RS03760	COG0832	Belongs to the urease beta subunit family
APRE_RS03765	COG0804	urea catabolic process
APRE_RS03775	COG1131	(ABC) transporter
APRE_RS03830	COG0745	RESPONSE REGULATOR receiver
APRE_RS03835	COG5002	protein histidine kinase activity
APRE_RS03840	COG1136	(ABC) transporter
APRE_RS03840	COG0577	efflux transmembrane transporter activity
APRE_RS03865	COG2183	response to ionizing radiation
APRE_RS03870	COG0442	prolyl-tRNA aminoacylation
APRE_RS03875	COG0191	fructose-bisphosphate aldolase activity
APRE_RS03880	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APRE_RS03885	COG0254	rRNA binding
APRE_RS03890	COG2890	protein-(glutamine-N5) methyltransferase activity
APRE_RS03895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APRE_RS03900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APRE_RS03905	COG0009	L-threonylcarbamoyladenylate synthase
APRE_RS03910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APRE_RS03915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APRE_RS03920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APRE_RS03925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APRE_RS03930	COG0772	Belongs to the SEDS family
APRE_RS03935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APRE_RS03940	COG0561	phosphatase activity
APRE_RS03945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APRE_RS03960	COG0126	phosphoglycerate kinase activity
APRE_RS03965	COG0149	triose-phosphate isomerase activity
APRE_RS03970	COG0148	phosphopyruvate hydratase activity
APRE_RS03980	COG0557	exoribonuclease II activity
APRE_RS03985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APRE_RS04030	COG0540	Belongs to the ATCase OTCase family
APRE_RS04035	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
APRE_RS04045	COG0284	orotidine-5'-phosphate decarboxylase activity
APRE_RS04050	COG0543	2 iron, 2 sulfur cluster binding
APRE_RS04055	COG0167	dihydroorotate dehydrogenase activity
APRE_RS04060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APRE_RS04085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APRE_RS04090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APRE_RS04095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APRE_RS04105	COG1621	beta-fructofuranosidase activity
APRE_RS04110	COG0582	viral genome integration into host DNA
APRE_RS04120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APRE_RS04190	COG0629	single-stranded DNA binding
APRE_RS04230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APRE_RS04275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APRE_RS04445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APRE_RS04450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APRE_RS04455	COG0297	glycogen (starch) synthase activity
APRE_RS04460	COG0058	SHG alpha-glucan phosphorylase activity
APRE_RS04465	COG1523	belongs to the glycosyl hydrolase 13 family
APRE_RS04470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APRE_RS04475	COG1716	ATPase activity
APRE_RS04485	COG0768	penicillin binding
APRE_RS04490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APRE_RS04500	COG4980	gas vesicle protein
APRE_RS04520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APRE_RS04530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
APRE_RS04535	COG2996	Protein conserved in bacteria
APRE_RS04545	COG2195	Cleaves the N-terminal amino acid of tripeptides
APRE_RS04570	COG0564	pseudouridine synthase activity
APRE_RS04580	COG0745	RESPONSE REGULATOR receiver
APRE_RS04585	COG5002	protein histidine kinase activity
APRE_RS04595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APRE_RS04620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APRE_RS04625	COG0632	four-way junction helicase activity
APRE_RS04630	COG2255	four-way junction helicase activity
APRE_RS04635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APRE_RS04640	COG0343	queuine tRNA-ribosyltransferase activity
APRE_RS04655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APRE_RS04665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APRE_RS04680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APRE_RS04685	COG1160	GTP binding
APRE_RS04690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APRE_RS04695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APRE_RS04700	COG1799	cell septum assembly
APRE_RS04715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APRE_RS04725	COG1104	cysteine desulfurase activity
APRE_RS04730	COG0301	tRNA thio-modification
APRE_RS04735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APRE_RS04740	COG2868	ribosomal protein
APRE_RS04750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APRE_RS04755	COG1534	Rna-binding protein
APRE_RS04760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APRE_RS04765	COG1713	HD superfamily hydrolase involved in NAD metabolism
APRE_RS04770	COG0799	negative regulation of ribosome biogenesis
APRE_RS04775	COG1596	polysaccharide export
APRE_RS04775	COG1555	photosystem II stabilization
APRE_RS04785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APRE_RS04790	COG4472	Bacterial protein of unknown function (DUF965)
APRE_RS04805	COG0735	belongs to the Fur family
APRE_RS04810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APRE_RS04815	COG4122	O-methyltransferase activity
APRE_RS04820	COG0826	peptidase U32
APRE_RS04830	COG2195	Cleaves the N-terminal amino acid of tripeptides
APRE_RS04835	COG0756	dUTP diphosphatase activity
APRE_RS04845	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APRE_RS04850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APRE_RS04855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APRE_RS04860	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
APRE_RS04865	COG4974	Belongs to the 'phage' integrase family
APRE_RS04870	COG1418	mRNA catabolic process
APRE_RS04875	COG1045	serine acetyltransferase
APRE_RS04885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APRE_RS04890	COG0052	Belongs to the universal ribosomal protein uS2 family
APRE_RS04895	COG0552	protein localization to endoplasmic reticulum
APRE_RS04900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APRE_RS04905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APRE_RS04935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APRE_RS04940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APRE_RS04945	COG0193	aminoacyl-tRNA hydrolase activity
APRE_RS04955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APRE_RS04960	COG0813	purine-nucleoside phosphorylase activity
APRE_RS04965	COG0698	ribose 5-phosphate isomerase
APRE_RS04970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APRE_RS04975	COG2337	Toxic component of a toxin-antitoxin (TA) module
APRE_RS04985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APRE_RS04985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APRE_RS04990	COG0402	S-adenosylhomocysteine deaminase activity
APRE_RS04995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APRE_RS05000	COG0154	amidase activity
APRE_RS05005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APRE_RS05010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APRE_RS05020	COG4496	protein, YerC YecD
APRE_RS05025	COG3442	glutamine amidotransferase
APRE_RS05030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APRE_RS05035	COG1254	Belongs to the acylphosphatase family
APRE_RS05050	COG1302	Protein conserved in bacteria
APRE_RS05090	COG0778	Nitroreductase
APRE_RS05105	COG1704	LemA family
APRE_RS05110	COG0602	queuosine metabolic process
APRE_RS05115	COG1328	CTP reductase activity
APRE_RS05115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APRE_RS05130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APRE_RS05135	COG1316	TRANSCRIPTIONal
APRE_RS05140	COG1982	Orn Lys Arg decarboxylase major
APRE_RS05185	COG1269	ATP hydrolysis coupled proton transport
APRE_RS05200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APRE_RS05205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APRE_RS05205	COG0539	negative regulation of cytoplasmic translation
APRE_RS05220	COG2081	HI0933 family
APRE_RS05225	COG1187	pseudouridine synthase activity
APRE_RS05230	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APRE_RS05240	COG0494	nUDIX hydrolase
APRE_RS05245	COG0497	DNA recombination
APRE_RS05250	COG1438	arginine binding
APRE_RS05265	COG1570	exodeoxyribonuclease VII activity
APRE_RS05280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APRE_RS05285	COG1323	Belongs to the UPF0348 family
APRE_RS05295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APRE_RS05300	COG0742	ribosomal rna small subunit methyltransferase
APRE_RS05305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APRE_RS05310	COG1461	Dihydroxyacetone kinase
APRE_RS05330	COG0322	excinuclease ABC activity
APRE_RS05335	COG0006	proline dipeptidase activity
APRE_RS05340	COG0012	GTP binding
APRE_RS05345	COG1435	thymidine kinase activity
APRE_RS05360	COG0210	DNA helicase
APRE_RS05365	COG0285	dihydrofolate synthase activity
APRE_RS05370	COG0693	protein deglycase activity
APRE_RS05385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APRE_RS05390	COG1307	EDD domain protein, DegV family
APRE_RS05395	COG1956	GAF domain-containing protein
APRE_RS05400	COG1393	Belongs to the ArsC family
APRE_RS05405	COG1473	amidohydrolase
APRE_RS05420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APRE_RS05425	COG1013	pyruvate-flavodoxin oxidoreductase activity
APRE_RS05425	COG0674	pyruvate-flavodoxin oxidoreductase activity
APRE_RS05425	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APRE_RS05425	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APRE_RS05430	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APRE_RS05435	COG0039	L-malate dehydrogenase activity
APRE_RS05440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
APRE_RS05440	COG0392	lysyltransferase activity
APRE_RS05455	COG2195	Cleaves the N-terminal amino acid of tripeptides
APRE_RS05460	COG1011	Hydrolase
APRE_RS05470	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APRE_RS05480	COG1309	transcriptional regulator
APRE_RS05495	COG3596	GTP binding
APRE_RS05505	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APRE_RS05510	COG2376	Dihydroxyacetone kinase
APRE_RS05520	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APRE_RS05565	COG1136	(ABC) transporter
APRE_RS05570	COG2205	protein histidine kinase activity
APRE_RS05590	COG1309	transcriptional regulator
APRE_RS05610	COG0372	Belongs to the citrate synthase family
APRE_RS05615	COG0473	3-isopropylmalate dehydrogenase activity
APRE_RS05620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APRE_RS05630	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APRE_RS05635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APRE_RS05640	COG0517	IMP dehydrogenase activity
APRE_RS05640	COG0516	GMP reductase activity
APRE_RS05645	COG0151	Belongs to the GarS family
APRE_RS05650	COG0138	bifunctional purine biosynthesis protein purh
APRE_RS05655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APRE_RS05660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APRE_RS05665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
APRE_RS05670	COG0402	S-adenosylhomocysteine deaminase activity
APRE_RS05680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APRE_RS05710	COG4129	membrane
APRE_RS05725	COG2768	binding domain, Protein
APRE_RS05730	COG1774	PSP1 C-terminal conserved region
APRE_RS05740	COG3870	Protein conserved in bacteria
APRE_RS05745	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APRE_RS05750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APRE_RS05755	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APRE_RS05760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APRE_RS05765	COG0791	NLP P60 protein
APRE_RS05765	COG1388	LysM domain
APRE_RS05765	COG3103	Sh3 type 3 domain protein
APRE_RS05780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APRE_RS05785	COG0358	DNA primase activity
APRE_RS05790	COG2207	Transcriptional regulator
APRE_RS05790	COG1917	Cupin 2, conserved barrel domain protein
APRE_RS05805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APRE_RS05820	COG2321	neutral zinc metallopeptidase
APRE_RS05825	COG0735	belongs to the Fur family
APRE_RS05830	COG0222	ribosome binding
APRE_RS05835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APRE_RS05840	COG0081	regulation of translation
APRE_RS05845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APRE_RS05850	COG0250	Participates in transcription elongation, termination and antitermination
APRE_RS05860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APRE_RS05870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APRE_RS05880	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APRE_RS05885	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APRE_RS05900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APRE_RS05905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APRE_RS05905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APRE_RS05920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APRE_RS05925	COG0537	adenosine 5'-monophosphoramidase activity
APRE_RS05930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APRE_RS05935	COG0484	heat shock protein binding
APRE_RS05940	COG0443	Heat shock 70 kDa protein
APRE_RS05945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APRE_RS05955	COG1250	3-hydroxyacyl-CoA dehydrogenase
APRE_RS05955	COG1024	Enoyl-CoA hydratase
APRE_RS05975	COG1595	DNA-templated transcription, initiation
APRE_RS05990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APRE_RS06010	COG1573	uracil-dna glycosylase
APRE_RS06015	COG0481	GTPase activity
APRE_RS06020	COG0681	Belongs to the peptidase S26 family
APRE_RS06025	COG0268	Binds directly to 16S ribosomal RNA
APRE_RS06035	COG2333	competence protein COMEC
APRE_RS06035	COG0658	competence protein
APRE_RS06090	COG0495	leucyl-tRNA aminoacylation
APRE_RS06100	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APRE_RS06105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APRE_RS06110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APRE_RS06120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APRE_RS06125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APRE_RS06130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APRE_RS06145	COG2001	Belongs to the MraZ family
APRE_RS06150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APRE_RS06155	COG0217	transcriptional regulatory protein
APRE_RS06160	COG1739	Uncharacterized protein family UPF0029
APRE_RS06165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APRE_RS06180	COG0745	RESPONSE REGULATOR receiver
APRE_RS06185	COG2205	protein histidine kinase activity
APRE_RS06205	COG1201	RNA secondary structure unwinding
APRE_RS06220	COG3001	Fructosamine kinase
APRE_RS06225	COG1846	Transcriptional regulator
APRE_RS06235	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APRE_RS06240	COG1177	transmembrane transport
APRE_RS06245	COG1176	ABC-type spermidine putrescine transport system, permease component I
APRE_RS06250	COG3842	ATPase activity
APRE_RS06260	COG3681	Belongs to the UPF0597 family
APRE_RS06265	COG0039	L-malate dehydrogenase activity
APRE_RS06270	COG2267	carboxylic ester hydrolase activity
APRE_RS06275	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
APRE_RS06295	COG1278	Cold shock
APRE_RS06305	COG0525	valine-tRNA ligase activity
APRE_RS06310	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APRE_RS06315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APRE_RS06315	COG0574	Belongs to the PEP-utilizing enzyme family
APRE_RS06320	COG1012	belongs to the aldehyde dehydrogenase family
APRE_RS06325	COG0733	neurotransmitter:sodium symporter activity
APRE_RS06330	COG0733	neurotransmitter:sodium symporter activity
APRE_RS06345	COG0653	protein targeting
APRE_RS06355	COG4946	Tricorn protease homolog
APRE_RS06355	COG1506	peptidase
APRE_RS06355	COG0823	Involved in the tonB-independent uptake of proteins
APRE_RS06360	COG1295	ribonuclease BN
APRE_RS06365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APRE_RS06370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APRE_RS06435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APRE_RS06440	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APRE_RS06445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APRE_RS06455	COG0728	peptidoglycan biosynthetic process
APRE_RS06460	COG0728	peptidoglycan biosynthetic process
APRE_RS06465	COG1316	TRANSCRIPTIONal
APRE_RS06490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APRE_RS06495	COG0572	uridine kinase
APRE_RS06500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APRE_RS06510	COG0590	tRNA wobble adenosine to inosine editing
APRE_RS06520	COG1686	Belongs to the peptidase S11 family
APRE_RS06535	COG1970	mechanosensitive ion channel activity
APRE_RS06540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APRE_RS06545	COG0758	DNA mediated transformation
APRE_RS06550	COG0792	nuclease activity
APRE_RS06555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APRE_RS06590	COG0336	Belongs to the RNA methyltransferase TrmD family
APRE_RS06595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APRE_RS06600	COG1837	Belongs to the UPF0109 family
APRE_RS06605	COG0228	four-way junction DNA binding
APRE_RS06610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APRE_RS06615	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
APRE_RS06635	COG1131	(ABC) transporter
APRE_RS06650	COG2137	regulation of response to DNA damage stimulus
APRE_RS06655	COG2827	Endonuclease containing a URI domain
APRE_RS06670	COG0768	penicillin binding
APRE_RS06680	COG1792	Involved in formation and maintenance of cell shape
APRE_RS06690	COG2003	Belongs to the UPF0758 family
APRE_RS06705	COG2878	Part of a membrane complex involved in electron transport
APRE_RS06705	COG1245	4Fe-4S binding domain
APRE_RS06710	COG4657	Part of a membrane complex involved in electron transport
APRE_RS06715	COG4660	Part of a membrane complex involved in electron transport
APRE_RS06725	COG4658	electron transport chain
APRE_RS06730	COG4656	Part of a membrane complex involved in electron transport
APRE_RS06745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APRE_RS06745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APRE_RS06845	COG0018	arginyl-trna synthetase
APRE_RS06850	COG1193	negative regulation of DNA recombination
APRE_RS06855	COG0826	peptidase U32
APRE_RS06865	COG0072	phenylalanine-tRNA ligase activity
APRE_RS06865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APRE_RS06870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APRE_RS06875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APRE_RS06880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APRE_RS06885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APRE_RS06890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APRE_RS06900	COG1307	EDD domain protein, DegV family
APRE_RS06910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APRE_RS06920	COG0427	acetyl-CoA hydrolase
APRE_RS06925	COG0183	Belongs to the thiolase family
APRE_RS06930	COG1250	3-hydroxyacyl-CoA dehydrogenase
APRE_RS06935	COG1024	Enoyl-CoA hydratase
APRE_RS06940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APRE_RS06950	COG1960	acyl-CoA dehydrogenase activity
APRE_RS06955	COG0277	FAD linked oxidase domain protein
APRE_RS06960	COG1380	Effector of murein hydrolase LrgA
APRE_RS06965	COG1346	cytolysis
APRE_RS06975	COG0789	Transcriptional regulator
APRE_RS06975	COG4978	Transcriptional regulator
APRE_RS06980	COG2033	superoxide reductase activity
APRE_RS07015	COG1132	(ABC) transporter
APRE_RS07020	COG1132	(ABC) transporter
APRE_RS07040	COG0728	peptidoglycan biosynthetic process
APRE_RS07060	COG0745	RESPONSE REGULATOR receiver
APRE_RS07065	COG0704	Plays a role in the regulation of phosphate uptake
APRE_RS07070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APRE_RS07080	COG0573	inorganic phosphate transmembrane transporter activity
APRE_RS07100	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APRE_RS07130	COG0561	phosphatase activity
APRE_RS07145	COG1528	Iron-storage protein
APRE_RS07160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APRE_RS07165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APRE_RS07175	COG0352	thiamine-phosphate diphosphorylase activity
APRE_RS07175	COG0351	phosphomethylpyrimidine kinase
APRE_RS07180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APRE_RS07190	COG1757	Na H antiporter
APRE_RS07205	COG1242	4 iron, 4 sulfur cluster binding
APRE_RS07210	COG0686	Belongs to the AlaDH PNT family
APRE_RS07225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APRE_RS07230	COG0556	nucleotide-excision repair
APRE_RS07235	COG0640	Transcriptional regulator
APRE_RS07245	COG2217	Heavy metal translocating P-type atpase
APRE_RS07255	COG1114	Component of the transport system for branched-chain amino acids
APRE_RS07260	COG0514	ATP-dependent DNA helicase (RecQ)
APRE_RS07275	COG0101	tRNA pseudouridine synthase activity
APRE_RS07280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APRE_RS07285	COG1122	ATPase activity
APRE_RS07290	COG1122	ATPase activity
APRE_RS07300	COG0116	Belongs to the methyltransferase superfamily
APRE_RS07305	COG2080	2 iron, 2 sulfur cluster binding
APRE_RS07310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APRE_RS07315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APRE_RS07335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APRE_RS07335	COG0493	'glutamate synthase
APRE_RS07340	COG0549	Belongs to the carbamate kinase family
APRE_RS07355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APRE_RS07360	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APRE_RS07370	COG1802	Transcriptional regulator
APRE_RS07375	COG0521	Mo-molybdopterin cofactor biosynthetic process
APRE_RS07390	COG0315	cyclic pyranopterin monophosphate synthase activity
APRE_RS07400	COG3842	ATPase activity
APRE_RS07405	COG4149	molybdate abc transporter
APRE_RS07410	COG0725	ABC transporter, periplasmic molybdate-binding protein
APRE_RS07480	COG0716	FMN binding
APRE_RS07515	COG1302	Protein conserved in bacteria
APRE_RS07530	COG0488	(ABC) transporter
APRE_RS07545	COG1217	gtp-binding protein TYPA
APRE_RS07555	COG1773	rubredoxin
APRE_RS07560	COG1773	rubredoxin
APRE_RS07585	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APRE_RS07595	COG1131	(ABC) transporter
APRE_RS07645	COG0446	pyridine nucleotide-disulphide oxidoreductase
APRE_RS07650	COG0579	oxidoreductase
APRE_RS07655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APRE_RS07660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
APRE_RS07665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APRE_RS07670	COG1187	pseudouridine synthase activity
APRE_RS07675	COG1695	Transcriptional regulator
APRE_RS07680	COG0210	DNA helicase
APRE_RS07690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APRE_RS07700	COG0459	protein refolding
APRE_RS07705	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APRE_RS07725	COG2081	HI0933 family
APRE_RS07730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APRE_RS07745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APRE_RS07755	COG0084	hydrolase, TatD family'
APRE_RS07760	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APRE_RS07760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APRE_RS07765	COG1115	amino acid carrier protein
APRE_RS07770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APRE_RS07790	COG1132	(ABC) transporter
APRE_RS07795	COG2197	response regulator
APRE_RS07815	COG1129	ABC transporter
APRE_RS07855	COG1827	regulation of RNA biosynthetic process
APRE_RS07860	COG0765	amino acid transport
APRE_RS07890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APRE_RS07900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APRE_RS07900	COG1263	PTS System
APRE_RS07920	COG1737	Transcriptional regulator
APRE_RS07925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APRE_RS07930	COG0203	ribosomal protein L17
APRE_RS07935	COG0202	RNA polymerase activity
APRE_RS07940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APRE_RS07945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APRE_RS07950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APRE_RS07955	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APRE_RS07960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APRE_RS07965	COG0563	adenylate kinase activity
APRE_RS07975	COG0200	Binds to the 23S rRNA
APRE_RS07980	COG1841	ribosomal large subunit assembly
APRE_RS07985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APRE_RS07995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APRE_RS08000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APRE_RS08005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APRE_RS08010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APRE_RS08015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APRE_RS08020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APRE_RS08025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APRE_RS08030	COG0255	Belongs to the universal ribosomal protein uL29 family
APRE_RS08035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APRE_RS08040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APRE_RS08045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APRE_RS08050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APRE_RS08060	COG0089	rRNA binding
APRE_RS08065	COG0088	Forms part of the polypeptide exit tunnel
APRE_RS08070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APRE_RS08075	COG0051	transcription antitermination factor activity, RNA binding
APRE_RS08090	COG1757	Na H antiporter
APRE_RS08115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APRE_RS08120	COG2723	6-phospho-beta-galactosidase activity
APRE_RS08125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APRE_RS08130	COG1447	Phosphotransferase system cellobiose-specific component IIA
APRE_RS08140	COG0205	6-phosphofructokinase activity
APRE_RS08145	COG1114	Component of the transport system for branched-chain amino acids
APRE_RS08160	COG2211	Major facilitator Superfamily
APRE_RS08165	COG2211	Major facilitator Superfamily
APRE_RS08170	COG0673	inositol 2-dehydrogenase activity
APRE_RS08180	COG0673	inositol 2-dehydrogenase activity
APRE_RS08185	COG0673	inositol 2-dehydrogenase activity
APRE_RS08195	COG0800	Aldolase
APRE_RS08200	COG1904	glucuronate isomerase
APRE_RS08205	COG1312	Catalyzes the dehydration of D-mannonate
APRE_RS08210	COG0246	Mannitol dehydrogenase
APRE_RS08215	COG0366	Alpha amylase catalytic
APRE_RS08220	COG3875	lactate racemase activity
APRE_RS08225	COG2059	Chromate
APRE_RS08235	COG3250	beta-galactosidase activity
APRE_RS08250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APRE_RS08255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APRE_RS08260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APRE_RS08265	COG1063	alcohol dehydrogenase
APRE_RS08280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APRE_RS08285	COG1879	ABC-type sugar transport system periplasmic component
APRE_RS08290	COG1172	Belongs to the binding-protein-dependent transport system permease family
APRE_RS08295	COG1129	ABC transporter
APRE_RS08300	COG1869	D-ribose catabolic process
APRE_RS08305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APRE_RS08315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APRE_RS08320	COG2971	BadF BadG BcrA BcrD
APRE_RS08325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APRE_RS08355	COG2022	thiamine diphosphate biosynthetic process
APRE_RS08360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APRE_RS08375	COG0822	iron-sulfur transferase activity
APRE_RS08380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APRE_RS08385	COG0719	Fe-S assembly protein
APRE_RS08395	COG0396	ATPase activity
APRE_RS08400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APRE_RS08405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APRE_RS08410	COG3688	RNA-binding protein containing a PIN domain
APRE_RS08415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APRE_RS08420	COG0215	cysteine-tRNA ligase activity
APRE_RS08425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APRE_RS08435	COG1164	Oligoendopeptidase f
APRE_RS08440	COG2309	aminopeptidase activity
APRE_RS08470	COG1476	TRANSCRIPTIONal
APRE_RS08475	COG0363	glucosamine-6-phosphate deaminase activity
APRE_RS08485	COG0166	Belongs to the GPI family
APRE_RS08505	COG0534	Mate efflux family protein
APRE_RS08515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APRE_RS08535	COG1175	transmembrane transport
APRE_RS08540	COG0395	ABC-type sugar transport system, permease component
APRE_RS08545	COG5426	von Willebrand factor, type A
APRE_RS08555	COG3842	ATPase activity
APRE_RS08560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APRE_RS08570	COG0366	Alpha amylase catalytic
APRE_RS08575	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APRE_RS08580	COG0446	pyridine nucleotide-disulphide oxidoreductase
APRE_RS08585	COG0431	NADPH-dependent FMN reductase
APRE_RS08595	COG1846	Transcriptional regulator
APRE_RS08605	COG1297	OPT oligopeptide transporter protein
APRE_RS08610	COG1253	flavin adenine dinucleotide binding
APRE_RS08615	COG1757	Na H antiporter
APRE_RS08620	COG1394	ATPase activity, coupled to movement of substances
APRE_RS08625	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
APRE_RS08635	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
APRE_RS08650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APRE_RS08655	COG1269	ATP hydrolysis coupled proton transport
APRE_RS08670	COG0438	transferase activity, transferring glycosyl groups
APRE_RS08675	COG1115	amino acid carrier protein
APRE_RS08680	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APRE_RS08685	COG1950	PFAM Membrane protein of
APRE_RS08695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APRE_RS08700	COG1714	RDD family
APRE_RS08715	COG1606	tRNA processing
APRE_RS08720	COG1691	(AIR) carboxylase
APRE_RS08725	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
APRE_RS08730	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
APRE_RS08740	COG4139	cobalamin transport
APRE_RS08745	COG1120	ATPase activity
APRE_RS08765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APRE_RS08770	COG1846	Transcriptional regulator
APRE_RS08780	COG0492	ferredoxin-NADP+ reductase activity
APRE_RS08815	COG1475	DNA binding
APRE_RS08820	COG1192	Involved in chromosome partitioning
APRE_RS08825	COG1058	Belongs to the CinA family
APRE_RS08825	COG1546	Belongs to the CinA family
APRE_RS08835	COG0357	Ribosomal RNA small subunit methyltransferase G
APRE_RS08840	COG0445	tRNA wobble uridine modification
APRE_RS08845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APRE_RS08850	COG1283	sodium-dependent phosphate transmembrane transporter activity
APRE_RS08855	COG1847	R3H domain protein
APRE_RS08860	COG0706	membrane insertase activity
APRE_RS08865	COG0594	ribonuclease P activity
APRE_RS08870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APRE_RS09205	COG1164	Oligoendopeptidase f
APRE_RS09290	COG2222	sugar isomerase
APRE_RS09420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding