locus-tag class description Ana3638_RS00025 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS00045 ENOG4105ECQ AraC Family Transcriptional Regulator Ana3638_RS00050 ENOG4105NWF RbsD or FucU transport Ana3638_RS00080 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS00095 ENOG4106PHM regulatory protein Ana3638_RS00105 ENOG4105EEM helicase Ana3638_RS00125 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Ana3638_RS00140 ENOG4105CID antiterminator Ana3638_RS00175 ENOG4105PTV Nudix Hydrolase Ana3638_RS00190 ENOG4105BZG amino acid carrier protein Ana3638_RS00195 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Ana3638_RS00235 ENOG4105E0S extracellular solute-binding protein family 1 Ana3638_RS00240 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS00265 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS00270 ENOG4105DSG hydrolase family 43 Ana3638_RS00275 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ana3638_RS00280 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS00285 ENOG410769Z extracellular solute-binding protein family 1 Ana3638_RS00305 ENOG4108JJB ABC transporter Ana3638_RS00330 ENOG4108UYE Lactoylglutathione lyase Ana3638_RS00345 ENOG4105D29 Helix-turn-helix type 11 domain protein Ana3638_RS00350 ENOG4105FAV ABC, transporter Ana3638_RS00355 ENOG4105DIK (ABC) transporter Ana3638_RS00360 ENOG4105DSE periplasmic solute binding protein Ana3638_RS00365 ENOG4105G5W regulator Fur family Ana3638_RS00420 ENOG4105EQD regulatoR Ana3638_RS00425 ENOG4105EG2 ABC transporter, permease Ana3638_RS00440 ENOG4105C2F Histidine kinase Ana3638_RS00455 ENOG4105NA0 Transcriptional regulator Ana3638_RS00460 ENOG4105CCN Peptidase M56 Ana3638_RS00465 ENOG41067QW Transcriptional regulator Ana3638_RS00485 ENOG4107RF6 penicillin-binding protein Ana3638_RS00500 ENOG4107RVG penicillin-binding protein Ana3638_RS00515 ENOG4108RCM Nitroreductase Ana3638_RS00525 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Ana3638_RS00535 ENOG4105KRI phosphocarrier protein (HPr Ana3638_RS00540 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein Ana3638_RS00545 ENOG4105DE4 1-phosphofructokinase Ana3638_RS00550 ENOG4105JF0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 2 Ana3638_RS00555 ENOG4105EMD TRANSCRIPTIONal Ana3638_RS00560 ENOG4105CTS PTS system mannitol-specific Ana3638_RS00570 ENOG4105WMR Protein CrcB homolog Ana3638_RS00575 ENOG4105WMR Protein CrcB homolog Ana3638_RS00585 ENOG4105E4C Lytic transglycosylase catalytic Ana3638_RS00595 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS00605 ENOG4105CP7 Triose-phosphate isomerase Ana3638_RS00615 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS00620 ENOG4105C8M UPF0272 protein Ana3638_RS00640 ENOG4105D2N Aldolase Ana3638_RS00645 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Ana3638_RS00660 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS00665 ENOG4108YZA Nitrogen regulatory protein pii Ana3638_RS00690 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS00695 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Ana3638_RS00700 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center Ana3638_RS00720 ENOG4108RAC Rubrerythrin Ana3638_RS00725 ENOG4105VCQ rubredoxin Ana3638_RS00730 ENOG4108Z5K methylglyoxal synthase Ana3638_RS00735 ENOG4105BZN citrate synthase Ana3638_RS00755 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Ana3638_RS00765 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Ana3638_RS00770 ENOG4105DY9 regulatoR Ana3638_RS00775 ENOG4108TGC Acyltransferase Ana3638_RS00780 ENOG4105UQX Mate efflux family protein Ana3638_RS00800 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) Ana3638_RS00805 ENOG4108FRU Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Ana3638_RS00815 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Ana3638_RS00830 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Ana3638_RS00835 ENOG4105CHR reductase Ana3638_RS00840 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Ana3638_RS00845 ENOG4105EA8 2-Nitropropane dioxygenase Ana3638_RS00850 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Ana3638_RS00870 ENOG4108IMY Transcriptional regulator Ana3638_RS00875 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Ana3638_RS00885 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Ana3638_RS00915 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Ana3638_RS00935 ENOG4105CZ3 stage V sporulation protein ad Ana3638_RS00960 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ana3638_RS00970 ENOG41082AN stage II sporulation protein Ana3638_RS00985 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Ana3638_RS01010 ENOG4107QZB decarboxylase Ana3638_RS01020 ENOG4105DRS transport system, permease Ana3638_RS01030 ENOG4108JE9 extracellular solute-binding protein family 1 Ana3638_RS01065 ENOG4107DB1 DUF218 domain Ana3638_RS01110 ENOG4105RHY Pfam:UPF0157 Ana3638_RS01130 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) Ana3638_RS01145 ENOG41068WN Ana3638_RS01160 ENOG4105BZ1 (ABC) transporter Ana3638_RS01165 ENOG4105BZ1 (ABC) transporter Ana3638_RS01175 ENOG4105DU6 RNA polymerase Ana3638_RS01185 ENOG4108FUT Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) Ana3638_RS01190 ENOG4105EJQ L-serine dehydratase Ana3638_RS01200 ENOG4108KPW sugar kinase Ana3638_RS01205 ENOG4105F8D glycoside hydrolase family 4 Ana3638_RS01210 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS01225 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS01255 ENOG4105DME alpha-galactosidase Ana3638_RS01260 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS01265 ENOG4105C4C beta-galactosidase Ana3638_RS01285 ENOG4108IG5 Transcriptional regulator Ana3638_RS01290 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Ana3638_RS01295 ENOG4105DUM transcriptional regulator, lysR family Ana3638_RS01305 ENOG410830R acetyltransferase Ana3638_RS01310 ENOG4105C26 Dehydrogenase Ana3638_RS01320 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Ana3638_RS01360 ENOG4108JP0 extracellular solute-binding protein family 1 Ana3638_RS01375 ENOG4107VHA regulatoR Ana3638_RS01385 ENOG4108IMY Transcriptional regulator Ana3638_RS01400 ENOG4105DT9 hydrolase family 43 Ana3638_RS01425 ENOG4105DRS transport system, permease Ana3638_RS01440 ENOG41063TF transcriptional regulator (AraC Ana3638_RS01445 ENOG4107HQ7 repeat protein Ana3638_RS01460 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Ana3638_RS01465 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Ana3638_RS01490 ENOG4105D1Z hydroxypyruvate reductase Ana3638_RS01495 ENOG4107VHA regulatoR Ana3638_RS01500 ENOG4105C5I Dehydrogenase Ana3638_RS01510 ENOG4105J4Q Transcriptional regulator Ana3638_RS01520 ENOG41060W2 glyoxylate carboligase Ana3638_RS01525 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Ana3638_RS01540 ENOG4105D29 Helix-turn-helix type 11 domain protein Ana3638_RS01550 ENOG4105C83 adenylosuccinate lyase Ana3638_RS01560 ENOG4105C8V SAICAR synthetase Ana3638_RS01565 ENOG4108NVR Methyl-accepting chemotaxis Ana3638_RS01575 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Ana3638_RS01580 ENOG4108D32 Methyltransferase Ana3638_RS01585 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Ana3638_RS01595 ENOG4105CMG Carbohydrate kinase Ana3638_RS01610 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) Ana3638_RS01620 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS01625 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Ana3638_RS01630 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination Ana3638_RS01635 ENOG4105CHR reductase Ana3638_RS01645 ENOG4105CHU acetyl-coa acetyltransferase Ana3638_RS01650 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme Ana3638_RS01655 ENOG4107S8A protein TIM barrel Ana3638_RS01665 ENOG4105JSC dimethylmenaquinone methyltransferase Ana3638_RS01680 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ana3638_RS01685 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS01690 ENOG4105ID8 Transcriptional regulator, ARAC family Ana3638_RS01705 ENOG4108DWA Nad synthetase Ana3638_RS01715 ENOG4108TQ9 Histidine kinase Ana3638_RS01720 ENOG4105BZU Histidine kinase Ana3638_RS01730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ana3638_RS01740 ENOG4105DZ6 Band 7 protein Ana3638_RS01750 ENOG4105VEQ Cold shock protein Ana3638_RS01765 ENOG4105BZU Histidine kinase Ana3638_RS01770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Ana3638_RS01775 ENOG4108UTW Plays a role in the regulation of phosphate uptake Ana3638_RS01780 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Ana3638_RS01785 ENOG4105E2Z phosphate ABC transporter (Permease Ana3638_RS01790 ENOG4105C8U phosphate abc transporter Ana3638_RS01795 ENOG4105CVA phosphate Ana3638_RS01805 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Ana3638_RS01810 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Ana3638_RS01820 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Ana3638_RS01825 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Ana3638_RS01845 ENOG4105F0V Cell wall hydrolase Ana3638_RS01850 ENOG4105CIH Imidazole acetol-phosphate transaminase Ana3638_RS01855 ENOG4105CHM Aminotransferase Ana3638_RS01870 ENOG4108IV0 ABC, transporter Ana3638_RS01875 ENOG4105C0Z ABC transporter Ana3638_RS01880 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Ana3638_RS01885 ENOG4105C32 Amino acid ABC transporter (Permease) Ana3638_RS01910 ENOG4105C0H protease Ana3638_RS01925 ENOG4108RCF TRANSCRIPTIONal Ana3638_RS01940 ENOG4107SJB teichoic acid biosynthesis Ana3638_RS01945 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase Ana3638_RS01950 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Ana3638_RS01955 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein Ana3638_RS01990 ENOG4105E0S extracellular solute-binding protein family 1 Ana3638_RS01995 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS02005 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS02010 ENOG4105CRK lysyL-tRNA synthetase Ana3638_RS02015 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Ana3638_RS02020 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) Ana3638_RS02025 ENOG4108N2Y auxin Efflux Ana3638_RS02035 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein Ana3638_RS02040 ENOG4105C45 hydrogenase expression formation protein (HypE) Ana3638_RS02045 ENOG4105CQS hydrogenase expression formation protein HypD Ana3638_RS02075 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ana3638_RS02085 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Ana3638_RS02090 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Ana3638_RS02095 ENOG4105C8S subunit m Ana3638_RS02125 ENOG4105RD7 BadF BadG BcrA BcrD Ana3638_RS02130 ENOG4105F8D glycoside hydrolase family 4 Ana3638_RS02135 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS02140 ENOG4105CT4 transporter Ana3638_RS02145 ENOG4105CS2 ec 3.2.1.21 Ana3638_RS02150 ENOG4108JJB ABC transporter Ana3638_RS02155 ENOG4108V4M Cobalt abc transporter Ana3638_RS02160 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Ana3638_RS02165 ENOG4105VPX protein, conserved in bacteria Ana3638_RS02170 ENOG4107S9D Alpha beta hydrolase Ana3638_RS02180 ENOG4105NA0 Transcriptional regulator Ana3638_RS02225 ENOG4105CDA abc transporter atp-binding protein Ana3638_RS02230 ENOG4105GBT ABC transporter Ana3638_RS02235 ENOG4108HW4 amino acid AbC transporter Ana3638_RS02250 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Ana3638_RS02295 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS02310 ENOG4105FDP GntR family transcriptional regulator Ana3638_RS02335 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Ana3638_RS02375 ENOG4105E09 nadh pyrophosphatase Ana3638_RS02395 ENOG4107ZT6 cytidine deaminase Ana3638_RS02505 ENOG41082UD thioesterase Superfamily protein Ana3638_RS02510 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Ana3638_RS02525 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Ana3638_RS02535 ENOG4105E5Q amino acid AbC transporter Ana3638_RS02540 ENOG4108HW3 (ABC) transporter Ana3638_RS02560 ENOG4105C98 muts2 protein Ana3638_RS02565 ENOG4105F5H Glycosyl Hydrolase Family 88 Ana3638_RS02580 ENOG4105C8I hydrolase, family 38 Ana3638_RS02605 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS02630 ENOG4105C8Y Acetylornithine aminotransferase Ana3638_RS02640 ENOG4105CDA abc transporter atp-binding protein Ana3638_RS02645 ENOG4105E5Q amino acid AbC transporter Ana3638_RS02650 ENOG4106PMH Extracellular solute-binding protein family 3 Ana3638_RS02695 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Ana3638_RS02700 ENOG4105CNT hydrolase family 2 Ana3638_RS02715 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS02720 ENOG4108IJG ABC transporter substrate-binding protein Ana3638_RS02730 ENOG4105VEQ Cold shock protein Ana3638_RS02745 ENOG4105D9Q decarboxylase (Beta subunit) Ana3638_RS02780 ENOG4105K4I Scp-like extracellular Ana3638_RS02795 ENOG4105BZ1 (ABC) transporter Ana3638_RS02800 ENOG4105BZ1 (ABC) transporter Ana3638_RS02820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS02830 ENOG4105DEF Extracellular solute-binding protein, family 5 Ana3638_RS02835 ENOG4105E2V Glycosyltransferase 36 Ana3638_RS02855 ENOG4108ME1 Peptidase M55 D-aminopeptidase Ana3638_RS02860 ENOG4107QK3 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 Ana3638_RS02870 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Ana3638_RS02875 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Ana3638_RS02905 ENOG4105E0M Sulfatase Ana3638_RS02920 ENOG4108RWN rrna methyltransferase Ana3638_RS02945 ENOG4105HFT AraC family transcriptional regulator Ana3638_RS02955 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Ana3638_RS02960 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Ana3638_RS02965 ENOG4105CBJ Metal-dependent enzyme Ana3638_RS02970 ENOG41082DI 50s ribosomal protein l31 Ana3638_RS02975 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Ana3638_RS02980 ENOG4105C6K Malic enzyme Ana3638_RS02985 ENOG4105N5T Radical SAM Protein Ana3638_RS02995 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Ana3638_RS03000 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Ana3638_RS03005 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Ana3638_RS03015 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Ana3638_RS03020 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Ana3638_RS03030 ENOG4105BZG amino acid carrier protein Ana3638_RS03040 ENOG4105CPF Cell wall formation (By similarity) Ana3638_RS03055 ENOG4105UIB (ABC) transporter Ana3638_RS03060 ENOG4108JQ9 ABC transporter Ana3638_RS03075 ENOG4105KVH Transcriptional regulator Ana3638_RS03085 ENOG4105EPR degv family Ana3638_RS03125 ENOG4105M59 Phosphodiesterase, mj0936 family Ana3638_RS03130 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Ana3638_RS03140 ENOG4105E8V Alpha Beta Hydrolase Fold protein Ana3638_RS03145 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Ana3638_RS03150 ENOG4105VFE sira family Ana3638_RS03245 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Ana3638_RS03250 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Ana3638_RS03260 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Ana3638_RS03270 ENOG410801F ribosomal-protein-alanine acetyltransferase Ana3638_RS03275 ENOG41072GX Peptidase M22 Glycoprotease Ana3638_RS03280 ENOG4105K8N protein family UPF0079, ATPase Ana3638_RS03325 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Ana3638_RS03330 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component Ana3638_RS03355 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS03365 ENOG4105E0S extracellular solute-binding protein family 1 Ana3638_RS03370 ENOG4105F5H Glycosyl Hydrolase Family 88 Ana3638_RS03405 ENOG4105EQD regulatoR Ana3638_RS03435 ENOG4106AXJ AraC family transcriptional regulator Ana3638_RS03440 ENOG410631K Membrane Ana3638_RS03445 ENOG4105BZU Histidine kinase Ana3638_RS03480 ENOG4105CPK Glycosyl transferase (Group 1 Ana3638_RS03500 ENOG4108KMV Glycosyl transferase (Group 1 Ana3638_RS03505 ENOG4105CG5 Glycosyl transferase (Group 1 Ana3638_RS03510 ENOG4105D75 Capsular exopolysaccharide family Ana3638_RS03520 ENOG4108RB3 Capsular polysaccharide biosynthesis protein Ana3638_RS03545 ENOG4105D3Q Sugar transferase Ana3638_RS03555 ENOG4108IMY Transcriptional regulator Ana3638_RS03600 ENOG4108RB3 Capsular polysaccharide biosynthesis protein Ana3638_RS03605 ENOG4105D3Q Sugar transferase Ana3638_RS03630 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Ana3638_RS03650 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Ana3638_RS03655 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Ana3638_RS03675 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Ana3638_RS03685 ENOG4105D06 uba thif-type nad fad binding protein Ana3638_RS03700 ENOG410810Y Sulfite reductase Ana3638_RS03715 ENOG4105EQD regulatoR Ana3638_RS03720 ENOG4105TMB Formate nitrite transporter Ana3638_RS03740 ENOG4105D6E homoserine dehydrogenase Ana3638_RS03745 ENOG41090I5 UPF0735 ACT domain-containing protein Ana3638_RS03750 ENOG4108V3W Chemotaxis protein, CheW Ana3638_RS03760 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Ana3638_RS03795 ENOG4105KME endoribonuclease L-psp Ana3638_RS03805 ENOG4105QNR S1 RNA binding domain protein Ana3638_RS03815 ENOG4105MJ2 Competence protein Ana3638_RS03825 ENOG4105C7H Helicase, RecD TraA family Ana3638_RS03835 ENOG4105CGA flagellar basal-body rod protein FlgG Ana3638_RS03850 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Ana3638_RS03855 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Ana3638_RS03860 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Ana3638_RS03865 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Ana3638_RS03875 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Ana3638_RS03885 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Ana3638_RS03895 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Ana3638_RS03900 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Ana3638_RS03905 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Ana3638_RS03915 ENOG4105WDJ 50S ribosomal protein L33 Ana3638_RS03930 ENOG4108R3D Electron transport complex Ana3638_RS03935 ENOG4105DGN Electron transport complex Ana3638_RS03940 ENOG4105DZB Electron transport complex Ana3638_RS03945 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit Ana3638_RS03950 ENOG4105D6A Electron transport complex Ana3638_RS03955 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Ana3638_RS03975 ENOG4105EAH synthase Ana3638_RS03985 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Ana3638_RS03990 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ana3638_RS04010 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS04020 ENOG4105C7N Xanthine uracil vitamin C permease Ana3638_RS04025 ENOG4105D7N magnesium and cobalt transport protein CorA Ana3638_RS04055 ENOG4107R7I amino acid Ana3638_RS04060 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Ana3638_RS04085 ENOG4105C6T cysteine synthase Ana3638_RS04090 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Ana3638_RS04095 ENOG4105FDP GntR family transcriptional regulator Ana3638_RS04110 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Ana3638_RS04115 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Ana3638_RS04135 ENOG4105C88 aminopeptidase Ana3638_RS04170 ENOG410607W Transposase Ana3638_RS04180 ENOG4108YZG isomerase Ana3638_RS04185 ENOG4107WAU Protein tyrosine phosphatase Ana3638_RS04190 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Ana3638_RS04195 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Ana3638_RS04215 ENOG4105D9P serine threonine protein kinase Ana3638_RS04220 ENOG4108S6Z Negative regulator of genetic competence Ana3638_RS04240 ENOG4105CDU Replicative dna helicase Ana3638_RS04245 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Ana3638_RS04250 ENOG4105BZR domain protein Ana3638_RS04255 ENOG4108Z7F N-acetyltransferase Ana3638_RS04270 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ana3638_RS04275 ENOG4105BZU Histidine kinase Ana3638_RS04290 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Ana3638_RS04300 ENOG4105C1A potassium transporter peripheral membrane Ana3638_RS04320 ENOG4105C08 Histidine kinase Ana3638_RS04325 ENOG4105EEX Two component transcriptional regulator (Winged helix family Ana3638_RS04330 ENOG4105C08 Histidine kinase Ana3638_RS04335 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Ana3638_RS04385 ENOG4108HWW ABC transporter Ana3638_RS04400 ENOG4105E98 transcriptional regulator DeoR family Ana3638_RS04405 ENOG4105C2J ABC transporter Ana3638_RS04435 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Ana3638_RS04440 ENOG4108UUM single-stranded DNA-binding protein Ana3638_RS04445 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Ana3638_RS04465 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Ana3638_RS04470 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS04485 ENOG4107V2S Transcriptional regulator Ana3638_RS04495 ENOG4108W2Y isochorismatase Ana3638_RS04515 ENOG4105EVU fructokinase Ana3638_RS04545 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Ana3638_RS04560 ENOG4105VDK protein, conserved in bacteria Ana3638_RS04565 ENOG4108UT2 hemolysin iii Ana3638_RS04575 ENOG4105KY8 Rubrerythrin Ana3638_RS04585 ENOG4105HY2 Glycosidase related protein Ana3638_RS04590 ENOG4105DFY n-acylglucosamine 2-epimerase Ana3638_RS04600 ENOG4105C1J atp-dependent rna helicase Ana3638_RS04620 ENOG4108IUW ABC transporter Ana3638_RS04630 ENOG4105VRS hydrolase family 18 Ana3638_RS04655 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS04675 ENOG4105DER m42 family Ana3638_RS04680 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) Ana3638_RS04685 ENOG4105CGK Exodeoxyribonuclease III Ana3638_RS04690 ENOG4107XGZ Hydrolase Ana3638_RS04705 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Ana3638_RS04715 ENOG4105RNB Ana3638_RS04720 ENOG4105BZ1 (ABC) transporter Ana3638_RS04725 ENOG4105BZ1 (ABC) transporter Ana3638_RS04815 ENOG4105C0A alcohol dehydrogenase Ana3638_RS04820 ENOG4105NPE arsR family transcriptional regulator Ana3638_RS04840 ENOG4105C75 arginyL-tRNA synthetase Ana3638_RS04850 ENOG4107SKW Inherit from COG: Alpha beta hydrolase Ana3638_RS04955 ENOG4108UHU Aldolase Ana3638_RS04975 ENOG4108ZDA Sporulation protein YyaC Ana3638_RS04985 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS05005 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Ana3638_RS05010 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Ana3638_RS05015 ENOG4105C6E dna polymerase iii Ana3638_RS05020 ENOG4108Z3G 3H domain protein Ana3638_RS05030 ENOG4108UQV Membrane Ana3638_RS05045 ENOG4107QYV phosphohexose isomerase Ana3638_RS05055 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Ana3638_RS05060 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS05070 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Ana3638_RS05080 ENOG4107QQR Sporulation Ana3638_RS05090 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS05095 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Ana3638_RS05105 ENOG4105I82 acetyl xylan esterase Ana3638_RS05110 ENOG4105K59 histidine triad (HIT) protein Ana3638_RS05115 ENOG4105CUX Signal transduction histidine kinase Ana3638_RS05125 ENOG4107ZXI Rhomboid family Ana3638_RS05130 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Ana3638_RS05240 ENOG4105DY9 regulatoR Ana3638_RS05245 ENOG4105DFM M18 family aminopeptidase Ana3638_RS05260 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ana3638_RS05265 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Ana3638_RS05275 ENOG4105BZ1 (ABC) transporter Ana3638_RS05280 ENOG4105BZ1 (ABC) transporter Ana3638_RS05285 ENOG4105D17 glycoside hydrolase, family 3 domain protein Ana3638_RS05290 ENOG4107URF beta-phospho-glucomutase Ana3638_RS05305 ENOG4105GR3 Histidine kinase Ana3638_RS05310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ana3638_RS05395 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Ana3638_RS05400 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Ana3638_RS05405 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Ana3638_RS05415 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Ana3638_RS05420 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Ana3638_RS05430 ENOG4105VG0 50S ribosomal protein l34 Ana3638_RS05435 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Ana3638_RS05440 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Ana3638_RS05450 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein Ana3638_RS05455 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Ana3638_RS05460 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Ana3638_RS05485 ENOG4107QJE Chromosome Partitioning Protein Ana3638_RS05490 ENOG4105FA0 parb-like partition protein Ana3638_RS05505 ENOG4105C0A alcohol dehydrogenase Ana3638_RS05510 ENOG4105CPI Metal Dependent Phosphohydrolase Ana3638_RS05525 ENOG4105DZ1 carboxypeptidase Ana3638_RS05545 ENOG4105CMD Transcriptional regulator, GntR family Ana3638_RS05550 ENOG4106C6A Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Ana3638_RS05555 ENOG4108JIP Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) Ana3638_RS05560 ENOG4108JIQ Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) Ana3638_RS05595 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Ana3638_RS05640 ENOG4105C01 Dihydroxy-acid dehydratase Ana3638_RS05660 ENOG4105CXN decarboxylase Ana3638_RS05665 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Ana3638_RS05670 ENOG4105XVJ Protein of unknown function (DUF327) Ana3638_RS05675 ENOG4105FA2 dna polymerase iii Ana3638_RS05680 ENOG4105MA4 psp1 domain protein Ana3638_RS05685 ENOG41060K3 Methyltransferase Ana3638_RS05690 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Ana3638_RS05695 ENOG4105KRN Transcriptional regulator, abrb family Ana3638_RS05700 ENOG4108JIC nucleoside recognition domain protein Ana3638_RS05730 ENOG4105EQD regulatoR Ana3638_RS05735 ENOG4105C2F Histidine kinase Ana3638_RS05775 ENOG4105CJ1 ABC, transporter Ana3638_RS05815 ENOG4108Z6Z Transcriptional regulator Ana3638_RS05820 ENOG4105WEF catalase Ana3638_RS05835 ENOG4105F8V Hydrolase, tatD family Ana3638_RS05840 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Ana3638_RS05845 ENOG4105CTQ phosphohexokinase Ana3638_RS05850 ENOG4105EQD regulatoR Ana3638_RS05855 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ana3638_RS05860 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 Ana3638_RS05865 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) Ana3638_RS05870 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase Ana3638_RS05895 ENOG4105D9U N-acetyltransferase Ana3638_RS05905 ENOG4108Z6B deaminase Ana3638_RS05925 ENOG4105CJ1 ABC, transporter Ana3638_RS05930 ENOG4105CJ1 ABC, transporter Ana3638_RS05955 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Ana3638_RS05965 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ana3638_RS05970 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Ana3638_RS05975 ENOG4105BZU Histidine kinase Ana3638_RS05980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ana3638_RS06010 ENOG41083IT Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Ana3638_RS06015 ENOG4108REF Sporulation integral membrane protein ytvi Ana3638_RS06020 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Ana3638_RS06025 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Ana3638_RS06030 ENOG4105ECQ AraC Family Transcriptional Regulator Ana3638_RS06035 ENOG4105CNT hydrolase family 2 Ana3638_RS06080 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Ana3638_RS06085 ENOG4108ZXQ stage ii sporulation protein r Ana3638_RS06100 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Ana3638_RS06135 ENOG4107RIS Acyl-transferase Ana3638_RS06140 ENOG4105DAP Nicotinate phosphoribosyltransferase Ana3638_RS06145 ENOG4108VXD carboxy-peptidase Ana3638_RS06170 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Ana3638_RS06195 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Ana3638_RS06215 ENOG4107QHI -hydrogenase Ana3638_RS06220 ENOG4107QIZ NADH dehydrogenase Ana3638_RS06235 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit Ana3638_RS06245 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Ana3638_RS06275 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ana3638_RS06280 ENOG4105Y5S NADH ubiquinone oxidoreductase, 24 kD Ana3638_RS06320 ENOG4105JVQ RNA Polymerase Ana3638_RS06350 ENOG4105VMP Transcriptional regulator Ana3638_RS06360 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) Ana3638_RS06390 ENOG4105CMD Transcriptional regulator, GntR family Ana3638_RS06410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS06420 ENOG4108JQ7 (ABC) transporter Ana3638_RS06450 ENOG4105KT7 mgtC SapB transporter Ana3638_RS06455 ENOG4105CK5 oxidoreductase Ana3638_RS06470 ENOG4105D7K pfkb domain protein Ana3638_RS06475 ENOG4105DH8 myo-inositol catabolism Ana3638_RS06480 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Ana3638_RS06485 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Ana3638_RS06490 ENOG4105C26 Dehydrogenase Ana3638_RS06495 ENOG4107TXC Transcriptional regulator Ana3638_RS06500 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Ana3638_RS06510 ENOG4105KWG Pfam:DUF1696 Ana3638_RS06515 ENOG4107RFY SbcCD D subunit Ana3638_RS06535 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Ana3638_RS06550 ENOG4105DFU Cell wall formation (By similarity) Ana3638_RS06555 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Ana3638_RS06560 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Ana3638_RS06565 ENOG4105K4W Could be involved in septation (By similarity) Ana3638_RS06580 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Ana3638_RS06600 ENOG4108IUW ABC transporter Ana3638_RS06605 ENOG4108SDH ABC, transporter Ana3638_RS06615 ENOG4108M14 stage v sporulation protein t Ana3638_RS06630 ENOG4105DXN mazG family Ana3638_RS06635 ENOG4105K70 DNA-binding protein Ana3638_RS06640 ENOG41082I2 s4 domain protein Ana3638_RS06645 ENOG4105VYY sporulation protein yabp Ana3638_RS06675 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Ana3638_RS06680 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Ana3638_RS06685 ENOG4108UGV hypoxanthine phosphoribosyltransferase Ana3638_RS06690 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ana3638_RS06750 ENOG41073R8 VanW family Ana3638_RS06760 ENOG4108ZB6 transcriptional regulator AsnC family Ana3638_RS06765 ENOG4105CHM Aminotransferase Ana3638_RS06785 ENOG4105BZU Histidine kinase Ana3638_RS06790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ana3638_RS06795 ENOG4105C98 muts2 protein Ana3638_RS06805 ENOG4105E2R ROK family Ana3638_RS06810 ENOG4105CK5 oxidoreductase Ana3638_RS06815 ENOG4107FKK extracellular solute-binding protein family 1 Ana3638_RS06845 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) Ana3638_RS06850 ENOG4105CIG ABC transporter Ana3638_RS06855 ENOG4105DIM ABC transporter Ana3638_RS06865 ENOG4105D9Q decarboxylase (Beta subunit) Ana3638_RS06885 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Ana3638_RS06890 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS06895 ENOG4105C3U ABC transporter Ana3638_RS06900 ENOG4108JQ7 (ABC) transporter Ana3638_RS06935 ENOG4105C59 p-type ATPase Ana3638_RS06945 ENOG4105C59 p-type ATPase Ana3638_RS06955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ana3638_RS06960 ENOG4105BZU Histidine kinase Ana3638_RS06970 ENOG4105C98 muts2 protein Ana3638_RS06995 ENOG4105BZU Histidine kinase Ana3638_RS07010 ENOG4105WEF catalase Ana3638_RS07020 ENOG4105EJ9 Membrane Ana3638_RS07045 ENOG4105WEF catalase Ana3638_RS07050 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Ana3638_RS07055 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Ana3638_RS07060 ENOG4105VKD bioY protein Ana3638_RS07065 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS07080 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ana3638_RS07085 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Ana3638_RS07105 ENOG4105VYW UPF0251 protein Ana3638_RS07115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Ana3638_RS07140 ENOG4105CKB glycosidase Ana3638_RS07160 ENOG4105DQX Zinc finger domain Ana3638_RS07165 ENOG41087YS Phage shock protein A Ana3638_RS07175 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Ana3638_RS07180 ENOG4107R37 Glutamate dehydrogenase Ana3638_RS07185 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Ana3638_RS07190 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Ana3638_RS07200 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Ana3638_RS07205 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Ana3638_RS07210 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Ana3638_RS07215 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Ana3638_RS07220 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Ana3638_RS07225 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Ana3638_RS07230 ENOG41082SA 50s ribosomal protein l29 Ana3638_RS07235 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Ana3638_RS07240 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Ana3638_RS07245 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Ana3638_RS07250 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Ana3638_RS07255 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Ana3638_RS07260 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Ana3638_RS07270 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Ana3638_RS07280 ENOG4105VPB 50S ribosomal protein L30 Ana3638_RS07290 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Ana3638_RS07310 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Ana3638_RS07315 ENOG41067V7 50S ribosomal protein L36 Ana3638_RS07320 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Ana3638_RS07325 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Ana3638_RS07330 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Ana3638_RS07340 ENOG4108ZT0 50S ribosomal protein l17 Ana3638_RS07345 ENOG4105C3F Signal peptidase i Ana3638_RS07350 ENOG4108JJB ABC transporter Ana3638_RS07355 ENOG4108JJB ABC transporter Ana3638_RS07360 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Ana3638_RS07370 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Ana3638_RS07375 ENOG4108UJD 30S ribosomal protein S9 Ana3638_RS07395 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Ana3638_RS07420 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) Ana3638_RS07425 ENOG4105CRK lysyL-tRNA synthetase Ana3638_RS07430 ENOG4105CHR reductase Ana3638_RS07440 ENOG4105E0S extracellular solute-binding protein family 1 Ana3638_RS07450 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS07455 ENOG4105EP8 Glycosyl Hydrolase Family 88 Ana3638_RS07465 ENOG4108JYZ YitT family Ana3638_RS07475 ENOG4105G9B Transcriptional regulator Ana3638_RS07480 ENOG4105CAK Cell division ATP-binding protein ftsE Ana3638_RS07485 ENOG4105CRP Part of the ABC transporter FtsEX involved in Ana3638_RS07495 ENOG4105CN1 protease Ana3638_RS07510 ENOG4105DK2 UPF0207 protein Ana3638_RS07520 ENOG4107EFR Flavocytochrome c Ana3638_RS07525 ENOG4105CJ2 (LipO)protein Ana3638_RS07550 ENOG4107XGZ Hydrolase Ana3638_RS07555 ENOG4105C5Y PTS System Ana3638_RS07565 ENOG4105DUM transcriptional regulator, lysR family Ana3638_RS07575 ENOG4105CAH Chromate Ana3638_RS07580 ENOG4105KNA -acetyltransferase Ana3638_RS07610 ENOG4107FB0 transcriptional regulator DeoR family Ana3638_RS07620 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Ana3638_RS07625 ENOG4105DIH basic membrane Ana3638_RS07630 ENOG4108JQ9 ABC transporter Ana3638_RS07645 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Ana3638_RS07650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Ana3638_RS07680 ENOG4105E1Q flagellar hook-associated protein Ana3638_RS07685 ENOG4105DTJ flagellar hook-associated protein Ana3638_RS07685 ENOG4105DTJ flagellar hook-associated protein Ana3638_RS07690 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Ana3638_RS07695 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Ana3638_RS07705 ENOG4107RT6 flagellar hook-associated Ana3638_RS07705 ENOG4107RT6 flagellar hook-associated Ana3638_RS07710 ENOG4105MQ3 flagellar protein FliS Ana3638_RS07720 ENOG4105I03 Flagellin Ana3638_RS07730 ENOG41090QV Protein of unknown function DUF115 Ana3638_RS07735 ENOG4105F0R Cytidylyltransferase Ana3638_RS07740 ENOG4105D2T synthase Ana3638_RS07755 ENOG4105C1B dTDP-glucose 4-6-dehydratase Ana3638_RS07815 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Ana3638_RS07820 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase Ana3638_RS07840 ENOG4105D2T synthase Ana3638_RS07845 ENOG4105F0R Cytidylyltransferase Ana3638_RS07860 ENOG4105CHU acetyl-coa acetyltransferase Ana3638_RS07890 ENOG4107TVC Glycosyl transferase, family 2 Ana3638_RS07900 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Ana3638_RS07910 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS07930 ENOG4105CNT hydrolase family 2 Ana3638_RS07940 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ana3638_RS07945 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Ana3638_RS07950 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Ana3638_RS07955 ENOG4105DKQ ROK family Ana3638_RS07960 ENOG4105D4A Cell wall formation (By similarity) Ana3638_RS07965 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Ana3638_RS07970 ENOG4105CIE May be required for sporulation (By similarity) Ana3638_RS07975 ENOG4105KRI phosphocarrier protein (HPr Ana3638_RS07985 ENOG4105C0B DNA polymerase III (alpha subunit) Ana3638_RS07995 ENOG4105BZ1 (ABC) transporter Ana3638_RS08000 ENOG4105EMN RNA polymerase sigma factor Ana3638_RS08015 ENOG4105PW4 Sugar fermentation stimulation protein homolog Ana3638_RS08045 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Ana3638_RS08060 ENOG410607W Transposase Ana3638_RS08075 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Ana3638_RS08120 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Ana3638_RS08165 ENOG41063TF transcriptional regulator (AraC Ana3638_RS08170 ENOG4105CJQ hydrolase, family 31 Ana3638_RS08205 ENOG4106AXJ AraC family transcriptional regulator Ana3638_RS08215 ENOG4108QBX (LipO)protein Ana3638_RS08220 ENOG41067SE Tetr family transcriptional regulator Ana3638_RS08225 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Ana3638_RS08230 ENOG4105K56 Transcriptional regulator Ana3638_RS08240 ENOG4107SET aldo keto reductase Ana3638_RS08245 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Ana3638_RS08255 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Ana3638_RS08260 ENOG4105MAX Superoxide reductase Ana3638_RS08285 ENOG4108JE9 extracellular solute-binding protein family 1 Ana3638_RS08295 ENOG4105DRS transport system, permease Ana3638_RS08305 ENOG4105C08 Histidine kinase Ana3638_RS08310 ENOG4105CJ3 phosphate transporter Ana3638_RS08335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Ana3638_RS08365 ENOG4105C02 permease Ana3638_RS08370 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ana3638_RS08390 ENOG4107R34 abc transporter permease protein Ana3638_RS08420 ENOG4108MRH transcriptional regulatory protein Ana3638_RS08435 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Ana3638_RS08440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS08460 ENOG4105EG2 ABC transporter, permease Ana3638_RS08465 ENOG4105CPC Aldo Keto reductase Ana3638_RS08470 ENOG4105WH1 Two component transcriptional regulator luxr family Ana3638_RS08475 ENOG4105BZU Histidine kinase Ana3638_RS08490 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS08495 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ana3638_RS08505 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Ana3638_RS08510 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Ana3638_RS08525 ENOG41085AS UPF0473 protein Ana3638_RS08590 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ana3638_RS08605 ENOG4107KJX Transcriptional regulator Ana3638_RS08655 ENOG4105C2F Histidine kinase Ana3638_RS08660 ENOG4105EQD regulatoR Ana3638_RS08675 ENOG4108AQF aminoglycoside N(3)-acetyltransferase Ana3638_RS08685 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Ana3638_RS08690 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Ana3638_RS08705 ENOG4108DMH HTH_ARAC Ana3638_RS08715 ENOG4105ST3 Transcriptional regulator Ana3638_RS08730 ENOG4108A04 Beta-lactamase Ana3638_RS08740 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Ana3638_RS08745 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS08765 ENOG4105D2N Aldolase Ana3638_RS08770 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS08780 ENOG4107WTH Galactitol-1-phosphate dehydrogenase Ana3638_RS08785 ENOG4105DE4 1-phosphofructokinase Ana3638_RS08795 ENOG4105EQD regulatoR Ana3638_RS08800 ENOG4105C2F Histidine kinase Ana3638_RS08805 ENOG4105C2J ABC transporter Ana3638_RS08810 ENOG4105CNN ABC, transporter Ana3638_RS08820 ENOG4108HWV )-transporter Ana3638_RS08830 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Ana3638_RS08840 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Ana3638_RS08865 ENOG4105C2F Histidine kinase Ana3638_RS08885 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS08890 ENOG4105DRS transport system, permease Ana3638_RS08895 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Ana3638_RS08905 ENOG410607W Transposase Ana3638_RS08930 ENOG4107QMU Mate efflux family protein Ana3638_RS08935 ENOG41082BM Transcriptional regulator, arsr family Ana3638_RS08945 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS08950 ENOG4105E0S extracellular solute-binding protein family 1 Ana3638_RS08955 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS08975 ENOG4105ECB domain protein Ana3638_RS08990 ENOG4105E0S extracellular solute-binding protein family 1 Ana3638_RS09000 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS09025 ENOG4107SJ9 decarboxylase Ana3638_RS09030 ENOG4105CPQ Dehydrogenase Ana3638_RS09050 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS09065 ENOG4105XJC Two component transcriptional regulator (Winged helix family Ana3638_RS09095 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component Ana3638_RS09135 ENOG4107QIV Cytochrome c biogenesis protein Ana3638_RS09140 ENOG4108YZG isomerase Ana3638_RS09145 ENOG4108RVA ribokinase Ana3638_RS09150 ENOG4108RVA ribokinase Ana3638_RS09180 ENOG4108KD5 ADP-ribosylation crystallin J1 Ana3638_RS09185 ENOG4105C2F Histidine kinase Ana3638_RS09190 ENOG4105EQD regulatoR Ana3638_RS09200 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS09225 ENOG4105X0R protein from nitrogen regulatory protein P-II Ana3638_RS09230 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS09240 ENOG4105CPC Aldo Keto reductase Ana3638_RS09245 ENOG4107QW4 alcohol dehydrogenase Ana3638_RS09260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Ana3638_RS09270 ENOG4105D38 putrescine abc transporter Ana3638_RS09275 ENOG4108HM4 ABC transporter Ana3638_RS09280 ENOG4105D5Q Arginine ornithine antiporter Ana3638_RS09290 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein Ana3638_RS09325 ENOG4105JAB phenazine biosynthesis protein, phzf family Ana3638_RS09330 ENOG4105KVH Transcriptional regulator Ana3638_RS09340 ENOG4108IJ0 Aspartate ammonia-lyase Ana3638_RS09345 ENOG4107T5V SNARE associated Golgi Ana3638_RS09365 ENOG4105K56 Transcriptional regulator Ana3638_RS09375 ENOG4105UQX Mate efflux family protein Ana3638_RS09385 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Ana3638_RS09390 ENOG4108R6K riboflavin synthase, subunit alpha Ana3638_RS09395 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Ana3638_RS09400 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Ana3638_RS09410 ENOG4107QW8 radical SAM domain protein Ana3638_RS09420 ENOG4108Z29 Flavodoxin Ana3638_RS09425 ENOG4108I0Z Aconitate hydratase Ana3638_RS09430 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) Ana3638_RS09440 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Ana3638_RS09470 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Ana3638_RS09475 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Ana3638_RS09480 ENOG4105C1B dTDP-glucose 4-6-dehydratase Ana3638_RS09485 ENOG4108MK9 spermidine N(1)-acetyltransferase Ana3638_RS09490 ENOG4105F0V Cell wall hydrolase Ana3638_RS09520 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS09535 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS09540 ENOG4105DRS transport system, permease Ana3638_RS09565 ENOG4107QW4 alcohol dehydrogenase Ana3638_RS09590 ENOG4105F6J Alpha beta hydrolase fold Ana3638_RS09595 ENOG4107QI1 Mate efflux family protein Ana3638_RS09600 ENOG4105KG3 cytidine deaminase Ana3638_RS09615 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Ana3638_RS09625 ENOG4105D7W serine acetyltransferase Ana3638_RS09630 ENOG4105C8N cysteinyl-tRNA synthetase Ana3638_RS09645 ENOG4105EU9 Ana3638_RS09655 ENOG4105QIV RNA polymerase Ana3638_RS09670 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS09675 ENOG4105C2F Histidine kinase Ana3638_RS09680 ENOG4105EQD regulatoR Ana3638_RS09695 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ana3638_RS09735 ENOG4105WPN DNA integration recombination invertion protein Ana3638_RS09755 ENOG4105CE1 Ferrous iron transport protein b Ana3638_RS09765 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Ana3638_RS09780 ENOG4108J59 Extracellular solute-binding protein, family 5 Ana3638_RS09785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Ana3638_RS09790 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS09795 ENOG4105C3U ABC transporter Ana3638_RS09800 ENOG4108JQ7 (ABC) transporter Ana3638_RS09815 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Ana3638_RS09825 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Ana3638_RS09830 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ana3638_RS09835 ENOG4108V39 SAM-dependent methyltransferase Ana3638_RS09865 ENOG4105CJ1 ABC, transporter Ana3638_RS09885 ENOG4105F0V Cell wall hydrolase Ana3638_RS09890 ENOG4107QID Threonine synthase Ana3638_RS09900 ENOG4107VDP teichoic acid biosynthesis Ana3638_RS09910 ENOG4105MFV ABC-2 type transporter Ana3638_RS09925 ENOG4105D3Q Sugar transferase Ana3638_RS09930 ENOG4105CMR udp-glucose 4-epimerase Ana3638_RS09935 ENOG4108PQP glycosyl transferase group 1 Ana3638_RS09940 ENOG4105K64 Glycosyl transferase, family 2 Ana3638_RS09950 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Ana3638_RS09955 ENOG4105MFV ABC-2 type transporter Ana3638_RS09960 ENOG4105EY8 ABC transporter Ana3638_RS09975 ENOG4107T7U Sulfatase Ana3638_RS09980 ENOG4105CBD Diacylglycerol kinase Ana3638_RS09985 ENOG4108TGC Acyltransferase Ana3638_RS10025 ENOG4108FPN Integrase Ana3638_RS10045 ENOG4105CDW Resistance protein Ana3638_RS10090 ENOG4105JXH GntR family transcriptional regulator Ana3638_RS10095 ENOG4108HHA Transketolase Ana3638_RS10100 ENOG4108IUS Transketolase Ana3638_RS10105 ENOG4105C5I Dehydrogenase Ana3638_RS10120 ENOG4107Z96 xylose isomerase Ana3638_RS10130 ENOG4105MKU Transcriptional regulator Ana3638_RS10150 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS10175 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Ana3638_RS10185 ENOG4105HFT AraC family transcriptional regulator Ana3638_RS10190 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Ana3638_RS10195 ENOG4105ID8 Transcriptional regulator, ARAC family Ana3638_RS10215 ENOG4105CK5 oxidoreductase Ana3638_RS10225 ENOG4105XN3 extracellular solute-binding protein family 1 Ana3638_RS10230 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS10235 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Ana3638_RS10240 ENOG4108HRK Histidine kinase Ana3638_RS10250 ENOG4105WH1 Two component transcriptional regulator luxr family Ana3638_RS10270 ENOG4108P49 AntiSigma factor Ana3638_RS10295 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS10300 ENOG4105CNT hydrolase family 2 Ana3638_RS10305 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Ana3638_RS10310 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) Ana3638_RS10315 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Ana3638_RS10325 ENOG4105E2Y ABC, transporter Ana3638_RS10330 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Ana3638_RS10370 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Ana3638_RS10380 ENOG4105K64 Glycosyl transferase, family 2 Ana3638_RS10405 ENOG4108RVA ribokinase Ana3638_RS10410 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase Ana3638_RS10420 ENOG4105C8M UPF0272 protein Ana3638_RS10430 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Ana3638_RS10435 ENOG4107XKF NMT1 THI5 Like Domain Protein Ana3638_RS10445 ENOG4105BZU Histidine kinase Ana3638_RS10450 ENOG4108REF Sporulation integral membrane protein ytvi Ana3638_RS10465 ENOG4105CI3 gtp-binding protein typa Ana3638_RS10480 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Ana3638_RS10485 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Ana3638_RS10495 ENOG4105CJ1 ABC, transporter Ana3638_RS10520 ENOG4105JFG SpoIID LytB domain protein Ana3638_RS10525 ENOG4107U9T Pfam:Ribonuclease_BN Ana3638_RS10535 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Ana3638_RS10540 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Ana3638_RS10580 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Ana3638_RS10585 ENOG4105CXB phosphoribosylaminoimidazole synthetase Ana3638_RS10590 ENOG4108V3E phosphoribosylglycinamide formyltransferase Ana3638_RS10595 ENOG4107QNG Phosphoribosylglycinamide synthetase Ana3638_RS10625 ENOG4108Z0C Uvrb UvrC protein Ana3638_RS10630 ENOG41066A3 ATP guanido phosphotransferase Ana3638_RS10645 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Ana3638_RS10650 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS10665 ENOG4108Z0Z intracellular protease Pfpi family Ana3638_RS10680 ENOG4108RAC Rubrerythrin Ana3638_RS10710 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Ana3638_RS10720 ENOG4105BZU Histidine kinase Ana3638_RS10725 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Ana3638_RS10730 ENOG4105VIE preprotein translocase, subunit YajC Ana3638_RS10735 ENOG4105DB7 PHP domain protein Ana3638_RS10750 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Ana3638_RS10755 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Ana3638_RS10760 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Ana3638_RS10765 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Ana3638_RS10770 ENOG4105C5X domain protein Ana3638_RS10775 ENOG4105D4P Coproporphyrinogen iii oxidase Ana3638_RS10785 ENOG4105CUT histidyl-tRNA synthetase Ana3638_RS10795 ENOG4105C9M aspartyl-trna synthetase Ana3638_RS10805 ENOG4105CPQ Dehydrogenase Ana3638_RS10810 ENOG4107KJX Transcriptional regulator Ana3638_RS10820 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS10825 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Ana3638_RS10865 ENOG4105CK7 Sodium proline symporter Ana3638_RS10870 ENOG4105DZS Phenylacetate-CoA ligase Ana3638_RS10890 ENOG4105DZS Phenylacetate-CoA ligase Ana3638_RS10920 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Ana3638_RS10925 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Ana3638_RS10940 ENOG4105UPD Calcium Proton Ana3638_RS10955 ENOG4105VRS hydrolase family 18 Ana3638_RS10960 ENOG4105VRS hydrolase family 18 Ana3638_RS10985 ENOG4105C2F Histidine kinase Ana3638_RS10990 ENOG4107VQW regulatoR Ana3638_RS11000 ENOG4105BZU Histidine kinase Ana3638_RS11005 ENOG4105DY9 regulatoR Ana3638_RS11025 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Ana3638_RS11035 ENOG4108V4M Cobalt abc transporter Ana3638_RS11045 ENOG4107PPM cobalt chelatase Ana3638_RS11050 ENOG4105DVK Precorrin-2 c20-methyltransferase Ana3638_RS11060 ENOG4105CIA precorrin-4 C(11)-methyltransferase Ana3638_RS11065 ENOG4108P62 biosynthesis protein (CbiG) Ana3638_RS11070 ENOG4105E4R Precorrin-3B C17-methyltransferase Ana3638_RS11075 ENOG4108JTQ reductase Ana3638_RS11080 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase Ana3638_RS11085 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Ana3638_RS11090 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Ana3638_RS11095 ENOG4108YZT Adenosylcobinamide kinase Ana3638_RS11100 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Ana3638_RS11115 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Ana3638_RS11120 ENOG4105CIH Imidazole acetol-phosphate transaminase Ana3638_RS11125 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Ana3638_RS11130 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Ana3638_RS11135 ENOG41081F0 Precorrin-8x methylmutase Ana3638_RS11140 ENOG4108IMY Transcriptional regulator Ana3638_RS11145 ENOG41090A1 ferritin Ana3638_RS11155 ENOG4105E14 MotA TolQ exbB proton channel Ana3638_RS11160 ENOG4105ER2 Ompa motb domain protein Ana3638_RS11170 ENOG4105C7J ABC transporter, permease Ana3638_RS11175 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Ana3638_RS11180 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ana3638_RS11200 ENOG4105CHM Aminotransferase Ana3638_RS11210 ENOG4105C5S asparaginyl-tRNA synthetase Ana3638_RS11215 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Ana3638_RS11220 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Ana3638_RS11225 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Ana3638_RS11255 ENOG4107UWA esterase Ana3638_RS11260 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Ana3638_RS11285 ENOG4105EPR degv family Ana3638_RS11290 ENOG4105C9U ATP-dependent DNA helicase RecQ Ana3638_RS11295 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Ana3638_RS11300 ENOG4108ZGC gaf domain protein Ana3638_RS11325 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ana3638_RS11345 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Ana3638_RS11350 ENOG4105C7Z Conserved Protein Ana3638_RS11365 ENOG4105C7Z Conserved Protein Ana3638_RS11375 ENOG4108VX5 3-methyladenine DNA glycosylase Ana3638_RS11390 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Ana3638_RS11400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Ana3638_RS11405 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS11410 ENOG4105C3U ABC transporter Ana3638_RS11415 ENOG4108JQ7 (ABC) transporter Ana3638_RS11420 ENOG4105E98 transcriptional regulator DeoR family Ana3638_RS11445 ENOG4105FKQ transcriptional regulator Ana3638_RS11475 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Ana3638_RS11480 ENOG4105C3R Methionine synthase Ana3638_RS11495 ENOG4105BZ1 (ABC) transporter Ana3638_RS11515 ENOG4107TXC Transcriptional regulator Ana3638_RS11520 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Ana3638_RS11525 ENOG41082JN Transcriptional regulator Ana3638_RS11535 ENOG4107QMU Mate efflux family protein Ana3638_RS11565 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Ana3638_RS11575 ENOG4105DTQ mandelate racemase muconate lactonizing Ana3638_RS11580 ENOG4105DIB Oligopeptide-binding protein Ana3638_RS11585 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Ana3638_RS11590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS11595 ENOG4105C3U ABC transporter Ana3638_RS11630 ENOG4107KJX Transcriptional regulator Ana3638_RS11650 ENOG4105D2X ABC transporter substrate-binding protein Ana3638_RS11680 ENOG4105KGF protein, YerC YecD Ana3638_RS11690 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) Ana3638_RS11755 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Ana3638_RS11995 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Ana3638_RS12000 ENOG4105C01 Dihydroxy-acid dehydratase Ana3638_RS12005 ENOG4105C4R Atp-dependent dna helicase Ana3638_RS12025 ENOG4105K56 Transcriptional regulator Ana3638_RS12035 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Ana3638_RS12075 ENOG4108YM7 Gcn5-related n-acetyltransferase Ana3638_RS12090 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Ana3638_RS12100 ENOG4107TXC Transcriptional regulator Ana3638_RS12145 ENOG4105XSJ toxin secretion phage lysis holin Ana3638_RS12215 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Ana3638_RS12220 ENOG4105EFC phage portal protein HK97 family Ana3638_RS12225 ENOG4105CAR Terminase, large subunit Ana3638_RS12260 ENOG4108ES9 ParB domain protein nuclease Ana3638_RS12305 ENOG4105C2M dna polymerase I Ana3638_RS12340 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Ana3638_RS12360 ENOG4107QMH DNA methylase Ana3638_RS12370 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Ana3638_RS12405 ENOG4108V4B ThiJ pfpI Ana3638_RS12420 ENOG4108W3Q Transcriptional regulator Ana3638_RS12440 ENOG4108594 Permease of the drug metabolite transporter Ana3638_RS12445 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS12460 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Ana3638_RS12470 ENOG4105C1J atp-dependent rna helicase Ana3638_RS12505 ENOG4105CF7 AraC family transcriptional regulator Ana3638_RS12510 ENOG4105C9B Cysteine desulfurase Ana3638_RS12530 ENOG4108RG0 uracil-dna glycosylase Ana3638_RS12540 ENOG41086D8 Transcriptional regulator Ana3638_RS12555 ENOG41090Y0 FMN-binding protein Ana3638_RS12565 ENOG4105D9P serine threonine protein kinase Ana3638_RS12575 ENOG41080UX Methyltransferase Ana3638_RS12590 ENOG4108IUW ABC transporter Ana3638_RS12605 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS12610 ENOG4107R88 Chemotaxis protein (CheV) Ana3638_RS12615 ENOG4105DY9 regulatoR Ana3638_RS12650 ENOG4108X07 Tetr family transcriptional regulator Ana3638_RS12670 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ana3638_RS12690 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ana3638_RS12695 ENOG4105DUM transcriptional regulator, lysR family Ana3638_RS12760 ENOG4105C5H ABC transporter Ana3638_RS12790 ENOG4108MCI Transcriptional regulator, ARAC family Ana3638_RS12815 ENOG4107EDW L-fucose operon activator Ana3638_RS12830 ENOG4107S9D Alpha beta hydrolase Ana3638_RS12885 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Ana3638_RS12900 ENOG4105C5X domain protein Ana3638_RS12910 ENOG4105E0A ABC, transporter Ana3638_RS12915 ENOG4105EHG Permease protein Ana3638_RS12930 ENOG4105E2A Dehydrogenase Ana3638_RS12955 ENOG4108JQ1 Dehydrogenase Ana3638_RS12965 ENOG4105C5I Dehydrogenase Ana3638_RS12990 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) Ana3638_RS13015 ENOG4105DSG hydrolase family 43 Ana3638_RS13065 ENOG4108WUH Transcriptional regulator, TetR family Ana3638_RS13070 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ana3638_RS13105 ENOG4108I5U Uridine phosphorylase Ana3638_RS13125 ENOG4108JJB ABC transporter Ana3638_RS13135 ENOG4105VRS hydrolase family 18 Ana3638_RS13140 ENOG41086D8 Transcriptional regulator Ana3638_RS13155 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ana3638_RS13175 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase Ana3638_RS13185 ENOG4108U05 Transcriptional regulator Ana3638_RS13190 ENOG4108HKT sucrose-6-phosphate hydrolase Ana3638_RS13195 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS13210 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) Ana3638_RS13235 ENOG4105X5K response regulator receiver protein Ana3638_RS13255 ENOG4107VUR extracellular solute-binding protein Ana3638_RS13260 ENOG4105C2F Histidine kinase Ana3638_RS13265 ENOG4107VQW regulatoR Ana3638_RS13270 ENOG4105C2J ABC transporter Ana3638_RS13285 ENOG4105CPQ Dehydrogenase Ana3638_RS13295 ENOG4105BZ1 (ABC) transporter Ana3638_RS13300 ENOG4105BZ1 (ABC) transporter Ana3638_RS13305 ENOG4105BZ1 (ABC) transporter Ana3638_RS13310 ENOG4105BZ1 (ABC) transporter Ana3638_RS13330 ENOG4105CPC Aldo Keto reductase Ana3638_RS13350 ENOG4105K56 Transcriptional regulator Ana3638_RS13355 ENOG4105BZU Histidine kinase Ana3638_RS13360 ENOG4108YZA Nitrogen regulatory protein pii Ana3638_RS13375 ENOG4108RE9 Phosphodiesterase Ana3638_RS13415 ENOG4107EFR Flavocytochrome c Ana3638_RS13420 ENOG4105M6F mutator MutT protein Ana3638_RS13425 ENOG4105BZU Histidine kinase Ana3638_RS13460 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS13480 ENOG4105DRS transport system, permease Ana3638_RS13485 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) Ana3638_RS13490 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) Ana3638_RS13495 ENOG4105E2R ROK family Ana3638_RS13515 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Ana3638_RS13520 ENOG410631K Membrane Ana3638_RS13525 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Ana3638_RS13535 ENOG41080XP Cbs domain Ana3638_RS13545 ENOG4105UQX Mate efflux family protein Ana3638_RS13570 ENOG4107QM2 Aldo Keto reductase Ana3638_RS13610 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Ana3638_RS13625 ENOG4105FCD Major Facilitator Ana3638_RS13640 ENOG4105CK5 oxidoreductase Ana3638_RS13655 ENOG4105BZ1 (ABC) transporter Ana3638_RS13660 ENOG4105BZ1 (ABC) transporter Ana3638_RS13680 ENOG4108ETT Dehydrogenase Ana3638_RS13705 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS13715 ENOG4105C5I Dehydrogenase Ana3638_RS13720 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Ana3638_RS13725 ENOG4105D1Z hydroxypyruvate reductase Ana3638_RS13730 ENOG4105W06 Cupin 2, conserved barrel domain protein Ana3638_RS13740 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase Ana3638_RS13745 ENOG4105IU0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Ana3638_RS13755 ENOG4105CE1 Ferrous iron transport protein b Ana3638_RS13770 ENOG4105E5Q amino acid AbC transporter Ana3638_RS13775 ENOG4105CDA abc transporter atp-binding protein Ana3638_RS13780 ENOG4105VRS hydrolase family 18 Ana3638_RS13785 ENOG4105BZ1 (ABC) transporter Ana3638_RS13795 ENOG4105K56 Transcriptional regulator Ana3638_RS13800 ENOG4108V06 Glutathione peroxidase Ana3638_RS13810 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) Ana3638_RS13815 ENOG4108YZA Nitrogen regulatory protein pii Ana3638_RS13840 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB Ana3638_RS13865 ENOG4108R6W Transcriptional regulator, ARAC family Ana3638_RS13880 ENOG4105DRS transport system, permease Ana3638_RS13900 ENOG4107T5V SNARE associated Golgi Ana3638_RS13955 ENOG4105MVE transcriptional regulator Ana3638_RS13960 ENOG4105G63 Type III effector Hrp-dependent Ana3638_RS13970 ENOG4105C6Z Gluconate Ana3638_RS13975 ENOG4105CE4 GlcNAc 6-P deacetylase Ana3638_RS13980 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Ana3638_RS13985 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) Ana3638_RS13990 ENOG4106KNT transcriptional regulator Ana3638_RS13995 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Ana3638_RS14000 ENOG4105C37 (CBS) domain Ana3638_RS14010 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Ana3638_RS14015 ENOG4105GPN Uncharacterized conserved protein (DUF2294) Ana3638_RS14025 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Ana3638_RS14060 ENOG4107YH3 SUF system FeS assembly protein, NifU family Ana3638_RS14070 ENOG4108393 oxidoreductase Fe-S subunit Ana3638_RS14080 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Ana3638_RS14085 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Ana3638_RS14095 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Ana3638_RS14100 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Ana3638_RS14130 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Ana3638_RS14135 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Ana3638_RS14140 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Ana3638_RS14145 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Ana3638_RS14150 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Ana3638_RS14175 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Ana3638_RS14180 ENOG4105CMR udp-glucose 4-epimerase Ana3638_RS14185 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase Ana3638_RS14195 ENOG4105EJQ L-serine dehydratase Ana3638_RS14215 ENOG41067S9 phage shock protein C, PspC Ana3638_RS14270 ENOG4105CKB glycosidase Ana3638_RS14285 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS14290 ENOG4105CZV ABC transporter Ana3638_RS14320 ENOG4105C3J Cysteine desulfurase Ana3638_RS14325 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Ana3638_RS14330 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Ana3638_RS14350 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Ana3638_RS14370 ENOG4108Z86 Glutamine amidotransferase Ana3638_RS14380 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase Ana3638_RS14390 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Ana3638_RS14395 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Ana3638_RS14400 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Ana3638_RS14405 ENOG4105C01 Dihydroxy-acid dehydratase Ana3638_RS14410 ENOG4105C7K acetolactate synthase Ana3638_RS14415 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Ana3638_RS14420 ENOG4108JQ1 Dehydrogenase Ana3638_RS14425 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Ana3638_RS14430 ENOG4105KMT branched-chain amino acid Ana3638_RS14435 ENOG4108UMN azlc family Ana3638_RS14445 ENOG4105DG6 mannose-6-phosphate isomerase Ana3638_RS14455 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Ana3638_RS14460 ENOG4105D64 Mechanosensitive ion channel Ana3638_RS14495 ENOG4105DKG l-rhamnose isomerase Ana3638_RS14500 ENOG4105C2F Histidine kinase Ana3638_RS14505 ENOG4107VQW regulatoR Ana3638_RS14510 ENOG4105C2J ABC transporter Ana3638_RS14515 ENOG4105CNN ABC, transporter Ana3638_RS14520 ENOG4105CNN ABC, transporter Ana3638_RS14525 ENOG4105D4B ABC, transporter Ana3638_RS14535 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS14540 ENOG4105FB2 class II Aldolase Ana3638_RS14555 ENOG4105CPQ Dehydrogenase Ana3638_RS14560 ENOG4108X49 Ethanolamine utilization protein EutK Ana3638_RS14565 ENOG4105KNY Microcompartments protein Ana3638_RS14575 ENOG4105KNY Microcompartments protein Ana3638_RS14580 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) Ana3638_RS14585 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml Ana3638_RS14590 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Ana3638_RS14600 ENOG4105E98 transcriptional regulator DeoR family Ana3638_RS14610 ENOG4105F1A Pyruvate formate-lyase Ana3638_RS14615 ENOG4105M3W utilization protein Ana3638_RS14620 ENOG4105KTW ethanolamine utilization protein Ana3638_RS14625 ENOG4107XVH Transcriptional regulator Ana3638_RS14650 ENOG4105C2F Histidine kinase Ana3638_RS14655 ENOG4105WH1 Two component transcriptional regulator luxr family Ana3638_RS14660 ENOG4105DFW ABC transporter Ana3638_RS14675 ENOG4105DDQ anthranilate synthase Ana3638_RS14680 ENOG4108I0Q anthranilate phosphoribosyltransferase Ana3638_RS14690 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Ana3638_RS14695 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Ana3638_RS14705 ENOG4105KVH Transcriptional regulator Ana3638_RS14720 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) Ana3638_RS14750 ENOG4107QRT dEAD DEAH box helicase Ana3638_RS14760 ENOG4108DBC nitroreductase Ana3638_RS14770 ENOG41086D8 Transcriptional regulator Ana3638_RS14780 ENOG41086D8 Transcriptional regulator Ana3638_RS14790 ENOG4105BZ1 (ABC) transporter Ana3638_RS14800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ana3638_RS14805 ENOG4105BZU Histidine kinase Ana3638_RS14815 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS14835 ENOG4105K4H Nlp p60 protein Ana3638_RS14855 ENOG4105C2F Histidine kinase Ana3638_RS14860 ENOG4108VAC response regulator Ana3638_RS14875 ENOG4105DRS transport system, permease Ana3638_RS14915 ENOG4108RAV Conserved protein Ana3638_RS14925 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Ana3638_RS14930 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) Ana3638_RS14950 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Ana3638_RS14955 ENOG4105CSA Coproporphyrinogen iii oxidase Ana3638_RS14960 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Ana3638_RS14965 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Ana3638_RS14970 ENOG4105CFG Acts as a chaperone (By similarity) Ana3638_RS14975 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Ana3638_RS14980 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Ana3638_RS14985 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Ana3638_RS14995 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) Ana3638_RS15010 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Ana3638_RS15015 ENOG4105VBH UPF0297 protein Ana3638_RS15020 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Ana3638_RS15030 ENOG4105I3K Ferric uptake regulator, Fur family Ana3638_RS15035 ENOG4105CN5 Metallo-Beta-Lactamase Ana3638_RS15050 ENOG4105CFP Peptidase U32 Ana3638_RS15055 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Ana3638_RS15060 ENOG4105CXN decarboxylase Ana3638_RS15065 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Ana3638_RS15085 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ana3638_RS15090 ENOG4107QHF type ii secretion system protein e Ana3638_RS15095 ENOG4105CZX twitching motility protein Ana3638_RS15110 ENOG4106A3R peptidase Ana3638_RS15150 ENOG4105WH5 Teichoic acid glycosylation protein Ana3638_RS15155 ENOG4105C5H ABC transporter Ana3638_RS15160 ENOG4107S9D Alpha beta hydrolase Ana3638_RS15180 ENOG4105BZU Histidine kinase Ana3638_RS15200 ENOG4105BZU Histidine kinase Ana3638_RS15215 ENOG4108QY0 Membrane Ana3638_RS15220 ENOG4105CXK mandelate racemase muconate lactonizing Ana3638_RS15225 ENOG4108UHU Aldolase Ana3638_RS15230 ENOG4105D7K pfkb domain protein Ana3638_RS15235 ENOG4107HP6 Transcriptional regulator Ana3638_RS15250 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS15270 ENOG4105D29 Helix-turn-helix type 11 domain protein Ana3638_RS15280 ENOG4107SET aldo keto reductase Ana3638_RS15295 ENOG4108W3Q Transcriptional regulator Ana3638_RS15300 ENOG4105EEM helicase Ana3638_RS15335 ENOG4108W2Y isochorismatase Ana3638_RS15350 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) Ana3638_RS15355 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Ana3638_RS15370 ENOG4105FE9 pseudouridine synthase Ana3638_RS15380 ENOG4105CVG Homoserine O-transsuccinylase Ana3638_RS15390 ENOG4105DBV ornithine carbamoyltransferase Ana3638_RS15415 ENOG4107UWY Methyltransferase Ana3638_RS15430 ENOG4108XXK NUDIX hydrolase Ana3638_RS15445 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Ana3638_RS15490 ENOG4105E7U AraC family transcriptional regulator Ana3638_RS15515 ENOG4105BZU Histidine kinase Ana3638_RS15525 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Ana3638_RS15535 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) Ana3638_RS15545 ENOG4107RVV histidinol phosphate phosphatase, hisj family Ana3638_RS15555 ENOG4105DSJ YicC domain protein Ana3638_RS15560 ENOG4105KC4 UPF0296 protein Ana3638_RS15565 ENOG4105YMY Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Ana3638_RS15590 ENOG4105E90 ABC transporter Ana3638_RS15595 ENOG4108IJ8 ABC transporter Ana3638_RS15615 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Ana3638_RS15620 ENOG4105C25 Primosomal protein n' Ana3638_RS15625 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Ana3638_RS15630 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Ana3638_RS15645 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Ana3638_RS15650 ENOG4108ZF3 Phosphatase Ana3638_RS15655 ENOG4105D9P serine threonine protein kinase Ana3638_RS15665 ENOG4105DJV ribulose-phosphate 3-epimerase Ana3638_RS15685 ENOG4108V6E Cell division protein mraZ Ana3638_RS15690 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Ana3638_RS15700 ENOG4105CJN penicillin-binding protein Ana3638_RS15705 ENOG4105CJN penicillin-binding protein Ana3638_RS15710 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Ana3638_RS15715 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Ana3638_RS15720 ENOG4105CNI cell division protein FtsW Ana3638_RS15725 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Ana3638_RS15735 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Ana3638_RS15740 ENOG4105FFI sigma-e processing peptidase spoiiga Ana3638_RS15745 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ana3638_RS15750 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ana3638_RS15760 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Ana3638_RS15770 ENOG4105C0P Mg chelatase subunit ChlI Ana3638_RS15775 ENOG4105C79 DNA protecting protein DprA Ana3638_RS15780 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Ana3638_RS15785 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) Ana3638_RS15790 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Ana3638_RS15795 ENOG4108ZC9 flagellar basal-body rod protein flgc Ana3638_RS15800 ENOG41081BH flagellar hook-basal body complex protein fliE Ana3638_RS15810 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Ana3638_RS15840 ENOG410822I Flagellar hook capping protein Ana3638_RS15850 ENOG4105BZE flagellar hook protein, FlgE Ana3638_RS15855 ENOG41068WV flagellar FlbD family protein Ana3638_RS15860 ENOG4105E14 MotA TolQ exbB proton channel Ana3638_RS15865 ENOG4105ER2 Ompa motb domain protein Ana3638_RS15875 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Ana3638_RS15880 ENOG4105DD5 Flagellar motor switch protein Ana3638_RS15885 ENOG4107YTP response regulator receiver protein Ana3638_RS15895 ENOG4105CN7 Flagellar biosynthetic protein FliP Ana3638_RS15900 ENOG4105VS8 Flagellar biosynthetic protein fliq Ana3638_RS15905 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Ana3638_RS15910 ENOG4105D00 flagellar biosynthetic protein flhB Ana3638_RS15915 ENOG4105D7B Flagellar biosynthesis protein flha Ana3638_RS15920 ENOG4105FZW flagellar biosynthesis regulator FlhF Ana3638_RS15935 ENOG4105CBS Chea signal transduction histidine kinase Ana3638_RS15940 ENOG4108V3W Chemotaxis protein, CheW Ana3638_RS15950 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Ana3638_RS15960 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Ana3638_RS15995 ENOG4106VK6 Flagellar motor protein Ana3638_RS16000 ENOG4105E14 MotA TolQ exbB proton channel Ana3638_RS16015 ENOG4105C2M dna polymerase I Ana3638_RS16020 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Ana3638_RS16025 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Ana3638_RS16030 ENOG4105Q2H domain protein Ana3638_RS16035 ENOG4105VUC UPF0237 protein Ana3638_RS16040 ENOG4105CAG UPF0210 protein Ana3638_RS16050 ENOG4105PNM synthesis protein Ana3638_RS16055 ENOG4108KGH TRANSCRIPTIONal Ana3638_RS16075 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Ana3638_RS16085 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Ana3638_RS16105 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Ana3638_RS16110 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Ana3638_RS16115 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Ana3638_RS16125 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Ana3638_RS16130 ENOG4105CHV Transcription elongation factor NusA Ana3638_RS16135 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination Ana3638_RS16140 ENOG4105VHM ribosomal protein Ana3638_RS16145 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Ana3638_RS16150 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Ana3638_RS16160 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Ana3638_RS16165 ENOG4105DTN riboflavin biosynthesis protein ribF Ana3638_RS16205 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Ana3638_RS16210 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Ana3638_RS16215 ENOG4108S0H Dipicolinic acid synthetase, b subunit Ana3638_RS16220 ENOG4105E35 Dipicolinate synthase subunit A Ana3638_RS16225 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Ana3638_RS16230 ENOG4105UQX Mate efflux family protein Ana3638_RS16240 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Ana3638_RS16250 ENOG4105E0C molybdate abc transporter Ana3638_RS16260 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Ana3638_RS16270 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Ana3638_RS16275 ENOG4105D29 Helix-turn-helix type 11 domain protein Ana3638_RS16290 ENOG4105C1V Peptidase, M16 Ana3638_RS16305 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS16315 ENOG4108HHA Transketolase Ana3638_RS16320 ENOG4108IUS Transketolase Ana3638_RS16325 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Ana3638_RS16330 ENOG4105CSA Coproporphyrinogen iii oxidase Ana3638_RS16340 ENOG4105KVH Transcriptional regulator Ana3638_RS16345 ENOG4108MDK Dehydrogenase Ana3638_RS16350 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit Ana3638_RS16375 ENOG4105C5S asparaginyl-tRNA synthetase Ana3638_RS16380 ENOG4108UZX fmn reductase Ana3638_RS16385 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Ana3638_RS16395 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Ana3638_RS16415 ENOG4105CXT aspartate transcarbamylase Ana3638_RS16425 ENOG4105D2H Uronic isomerase Ana3638_RS16430 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS16435 ENOG4107QZW Altronate oxidoreductase Ana3638_RS16440 ENOG4105CTX dehydratase Ana3638_RS16450 ENOG4105F5H Glycosyl Hydrolase Family 88 Ana3638_RS16455 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS16460 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ana3638_RS16475 ENOG4107KJX Transcriptional regulator Ana3638_RS16480 ENOG4107QM5 aconitate hydratase Ana3638_RS16485 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Ana3638_RS16500 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Ana3638_RS16505 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Ana3638_RS16510 ENOG4105CEV competence damage-inducible protein Ana3638_RS16525 ENOG4105CBX hi0933 family Ana3638_RS16530 ENOG4105CAT Cytidine monophosphate kinase Ana3638_RS16540 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Ana3638_RS16545 ENOG4105BZU Histidine kinase Ana3638_RS16550 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Ana3638_RS16560 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Ana3638_RS16565 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Ana3638_RS16570 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Ana3638_RS16575 ENOG4105C7B Threonine dehydratase Ana3638_RS16600 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein Ana3638_RS16605 ENOG4107QSA Oxaloacetate decarboxylase Ana3638_RS16630 ENOG4105K5M 30s ribosomal protein S16 Ana3638_RS16640 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Ana3638_RS16645 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Ana3638_RS16650 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Ana3638_RS16670 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Ana3638_RS16675 ENOG4105VM1 flagellar Ana3638_RS16680 ENOG4105VFF UPF0102 protein Ana3638_RS16690 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Ana3638_RS16700 ENOG4105C1B dTDP-glucose 4-6-dehydratase Ana3638_RS16715 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Ana3638_RS16735 ENOG4105K4H Nlp p60 protein Ana3638_RS16740 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Ana3638_RS16745 ENOG4105DIN metallophosphoesterase Ana3638_RS16760 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Ana3638_RS16765 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Ana3638_RS16775 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Ana3638_RS16780 ENOG4105CXI aluminum resistance protein Ana3638_RS16790 ENOG4105W5Q DNA repair protein (RadC Ana3638_RS16810 ENOG4105CJN penicillin-binding protein Ana3638_RS16820 ENOG4107QMS site-determining protein Ana3638_RS16825 ENOG41083CN Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Ana3638_RS16830 ENOG4105CNI cell division protein FtsW Ana3638_RS16835 ENOG4108Z5K methylglyoxal synthase Ana3638_RS16840 ENOG4105DZ1 carboxypeptidase Ana3638_RS16850 ENOG4105WG9 Conserved Protein Ana3638_RS16860 ENOG4105DFA alanine racemase domain protein Ana3638_RS16870 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Ana3638_RS16885 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) Ana3638_RS16895 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Ana3638_RS16900 ENOG4105C34 Pseudouridine synthase Ana3638_RS16920 ENOG4105C26 Dehydrogenase Ana3638_RS16925 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS16945 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator Ana3638_RS16965 ENOG41067QW Transcriptional regulator Ana3638_RS17015 ENOG4108R6W Transcriptional regulator, ARAC family Ana3638_RS17025 ENOG4105C0R drug resistance transporter emrb qaca subfamily Ana3638_RS17050 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase Ana3638_RS17055 ENOG41082BM Transcriptional regulator, arsr family Ana3638_RS17060 ENOG4105D6J arsenicaL-resistance protein Ana3638_RS17080 ENOG4105CEY Amp-dependent synthetase and ligase Ana3638_RS17090 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Ana3638_RS17135 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Ana3638_RS17140 ENOG4105C8T Leucyl-tRNA synthetase Ana3638_RS17170 ENOG4105BZ1 (ABC) transporter Ana3638_RS17180 ENOG4107X8C Efflux transporter RND family MFP subunit Ana3638_RS17215 ENOG4105EE0 oxidoreductase Ana3638_RS17220 ENOG4105CPC Aldo Keto reductase Ana3638_RS17225 ENOG4108FN7 Aldo keto reductase Ana3638_RS17230 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Ana3638_RS17235 ENOG4105DWF phosphomethylpyrimidine kinase Ana3638_RS17240 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 Ana3638_RS17255 ENOG4105UEI Transcriptional Regulator AraC Family Ana3638_RS17260 ENOG4105F32 YngK protein Ana3638_RS17265 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Ana3638_RS17275 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Ana3638_RS17295 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Ana3638_RS17310 ENOG4105K64 Glycosyl transferase, family 2 Ana3638_RS17335 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Ana3638_RS17340 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Ana3638_RS17345 ENOG4108WF2 Metal Dependent Phosphohydrolase Ana3638_RS17350 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Ana3638_RS17355 ENOG410812S Rna-binding protein Ana3638_RS17360 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Ana3638_RS17365 ENOG4105K46 50S ribosomal protein l27 Ana3638_RS17370 ENOG4105X36 (ribosomal) protein Ana3638_RS17375 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Ana3638_RS17385 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Ana3638_RS17390 ENOG4105CP2 von willebrand factor, type a Ana3638_RS17395 ENOG4108Z66 YbaK ebsC protein Ana3638_RS17420 ENOG4105X71 Membrane Ana3638_RS17425 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Ana3638_RS17440 ENOG4105C0D helicase Ana3638_RS17455 ENOG4105BZU Histidine kinase Ana3638_RS17470 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS17485 ENOG4108HRK Histidine kinase Ana3638_RS17495 ENOG4105EQD regulatoR Ana3638_RS17510 ENOG4108VAC response regulator Ana3638_RS17520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Ana3638_RS17535 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) Ana3638_RS17545 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) Ana3638_RS17555 ENOG4105ID8 Transcriptional regulator, ARAC family Ana3638_RS17560 ENOG4105CKI cobalamin synthesis protein Ana3638_RS17570 ENOG4108Q52 Methyltransferase cognate corrinoid protein Ana3638_RS17580 ENOG4105DZ1 carboxypeptidase Ana3638_RS17610 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS17630 ENOG4105HDK L-asparaginase Ana3638_RS17635 ENOG4105C4B ABC transporter, permease Ana3638_RS17640 ENOG41083J0 (ABC) transporter Ana3638_RS17645 ENOG4105CPF Cell wall formation (By similarity) Ana3638_RS17680 ENOG4105NBF ammecr1 domain protein Ana3638_RS17690 ENOG4105EPR degv family Ana3638_RS17705 ENOG4105E1K spore germination protein Ana3638_RS17710 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Ana3638_RS17715 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Ana3638_RS17730 ENOG4105DZ1 carboxypeptidase Ana3638_RS17735 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ana3638_RS17740 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ana3638_RS17745 ENOG4107X8C Efflux transporter RND family MFP subunit Ana3638_RS17770 ENOG4105UIB (ABC) transporter Ana3638_RS17775 ENOG4108JQ9 ABC transporter Ana3638_RS17780 ENOG4105DIH basic membrane Ana3638_RS17795 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) Ana3638_RS17810 ENOG4105C19 ABC transporter Ana3638_RS17815 ENOG4105EWM Histidine kinase Ana3638_RS17820 ENOG4105CJZ response regulator Ana3638_RS17845 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Ana3638_RS17850 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Ana3638_RS17855 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Ana3638_RS17870 ENOG4105II7 pyrroline-5-carboxylate reductase Ana3638_RS17880 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Ana3638_RS17885 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Ana3638_RS17895 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Ana3638_RS17905 ENOG410867X UPF0291 protein Ana3638_RS17910 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Ana3638_RS17915 ENOG4105DZ0 fad dependent oxidoreductase Ana3638_RS17920 ENOG4105CBX hi0933 family Ana3638_RS17930 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Ana3638_RS17940 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Ana3638_RS17945 ENOG4105D52 delta-aminolevulinic acid dehydratase Ana3638_RS17960 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Ana3638_RS17965 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Ana3638_RS17975 ENOG4105NWF RbsD or FucU transport Ana3638_RS17980 ENOG4105DET Rhamnulokinase Ana3638_RS17985 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) Ana3638_RS18000 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 Ana3638_RS18010 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) Ana3638_RS18035 ENOG4105ECW sulfate abc transporter Ana3638_RS18040 ENOG4108I5D sulfate abc transporter Ana3638_RS18045 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Ana3638_RS18065 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Ana3638_RS18070 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Ana3638_RS18075 ENOG4105C9A Phoh family Ana3638_RS18090 ENOG4105VCC 30S ribosomal protein S21 Ana3638_RS18095 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Ana3638_RS18120 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Ana3638_RS18125 ENOG4105DZP Membrane-associated zinc metalloprotease Ana3638_RS18130 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Ana3638_RS18135 ENOG4105KNE Phosphatidate cytidylyltransferase Ana3638_RS18145 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Ana3638_RS18160 ENOG4107VMI polysaccharide deacetylase Ana3638_RS18175 ENOG4108R66 Conserved Protein Ana3638_RS18180 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS18200 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Ana3638_RS18205 ENOG4105CE9 30S ribosomal protein S2 Ana3638_RS18210 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Ana3638_RS18220 ENOG4107QHZ cell cycle protein Ana3638_RS18230 ENOG4105CFP Peptidase U32 Ana3638_RS18235 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) Ana3638_RS18240 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Ana3638_RS18245 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Ana3638_RS18255 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Ana3638_RS18270 ENOG41082GS 50S ribosomal protein L32 Ana3638_RS18280 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Ana3638_RS18290 ENOG4105DHT Metal Dependent Phosphohydrolase Ana3638_RS18310 ENOG4108VAC response regulator Ana3638_RS18320 ENOG4105DPN Oligoendopeptidase f Ana3638_RS18325 ENOG4105H20 Sporulation integral membrane protein YlbJ Ana3638_RS18335 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Ana3638_RS18340 ENOG4106H78 methyltransferase Ana3638_RS18360 ENOG4105CKK Glycosyl transferase, family 2 Ana3638_RS18375 ENOG4106F1P AAA ATPase, central domain protein Ana3638_RS18380 ENOG4105CB5 ATP-dependent DNA helicase recG Ana3638_RS18385 ENOG4105DP4 dak2 domain fusion protein ylov Ana3638_RS18390 ENOG4108ZAA Alkaline-shock protein Ana3638_RS18395 ENOG4105VB9 50S ribosomal protein l28 Ana3638_RS18455 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Ana3638_RS18465 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Ana3638_RS18470 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Ana3638_RS18485 ENOG4107R88 Chemotaxis protein (CheV) Ana3638_RS18520 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Ana3638_RS18525 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Ana3638_RS18530 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Ana3638_RS18535 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Ana3638_RS18545 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Ana3638_RS18550 ENOG4105C5H ABC transporter Ana3638_RS18555 ENOG4105DRR Transcriptional regulator, GntR family Ana3638_RS18560 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Ana3638_RS18565 ENOG4107SDT Homocitrate synthase Ana3638_RS18570 ENOG4105C5B carbamate kinase Ana3638_RS18575 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS18580 ENOG4105CAQ asparagine synthetase Ana3638_RS18585 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS18595 ENOG41067QW Transcriptional regulator Ana3638_RS18605 ENOG4105D01 (LipO)protein Ana3638_RS18610 ENOG4108UMI ABC transporter, permease Ana3638_RS18640 ENOG4105BZU Histidine kinase Ana3638_RS18645 ENOG4105EYH Exonuclease Ana3638_RS18655 ENOG4105CUZ uba thif-type nad fad binding protein Ana3638_RS18660 ENOG4105CD3 dihydroorotase Ana3638_RS18675 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Ana3638_RS18690 ENOG4107XBN GntR Family Transcriptional Regulator Ana3638_RS18695 ENOG4105DEI Mannitol dehydrogenase Ana3638_RS18700 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) Ana3638_RS18725 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Ana3638_RS18765 ENOG4105E5Q amino acid AbC transporter Ana3638_RS18795 ENOG41083UI stage II sporulation protein Ana3638_RS18810 ENOG4108JJA ABC, transporter Ana3638_RS18815 ENOG4108JJA ABC, transporter Ana3638_RS18845 ENOG4105DY9 regulatoR Ana3638_RS18855 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Ana3638_RS18875 ENOG4105XIV Mercuric transport protein, periplasmic component Ana3638_RS18890 ENOG4107Y70 Heat shock protein Ana3638_RS18900 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Ana3638_RS18905 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Ana3638_RS18910 ENOG4108RAC Rubrerythrin Ana3638_RS18915 ENOG4105DQU oxidoreductase, subunit beta Ana3638_RS18935 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Ana3638_RS18940 ENOG4108IMY Transcriptional regulator Ana3638_RS18950 ENOG4105F38 ABC transporter, permease Ana3638_RS18955 ENOG4105D38 putrescine abc transporter Ana3638_RS18960 ENOG4107RUE extracellular solute-binding protein family 1 Ana3638_RS18965 ENOG4105C5I Dehydrogenase Ana3638_RS18970 ENOG4105C31 Tryptophanyl-tRNA synthetase Ana3638_RS18980 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) Ana3638_RS18995 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator Ana3638_RS19000 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS19005 ENOG4105C8T Leucyl-tRNA synthetase Ana3638_RS19010 ENOG4105S7A ErfK ybiS ycfS ynhG family protein Ana3638_RS19015 ENOG4105BZ1 (ABC) transporter Ana3638_RS19040 ENOG4107QSI ABC, transporter Ana3638_RS19050 ENOG4105C3U ABC transporter Ana3638_RS19055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS19060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Ana3638_RS19070 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Ana3638_RS19080 ENOG4105CH7 arginosuccinase Ana3638_RS19090 ENOG41082BM Transcriptional regulator, arsr family Ana3638_RS19105 ENOG4108RCF TRANSCRIPTIONal Ana3638_RS19140 ENOG4108WQI RNA Polymerase Ana3638_RS19155 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein Ana3638_RS19170 ENOG4105D5G Transposase Ana3638_RS19195 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein Ana3638_RS19210 ENOG4105XSJ toxin secretion phage lysis holin Ana3638_RS19280 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Ana3638_RS19290 ENOG4105CAR Terminase, large subunit Ana3638_RS19435 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Ana3638_RS19445 ENOG4108EC8 DNA internalization-related competence protein ComEC Ana3638_RS19455 ENOG4105BZU Histidine kinase Ana3638_RS19465 ENOG4105KQC Competence protein Ana3638_RS19480 ENOG4108IG5 Transcriptional regulator Ana3638_RS19485 ENOG4105C8Y Acetylornithine aminotransferase Ana3638_RS19490 ENOG4105CAS nag kinase Ana3638_RS19495 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Ana3638_RS19500 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Ana3638_RS19505 ENOG4108Z03 MAF-like protein Ana3638_RS19510 ENOG4105CDH Citrulline--aspartate ligase Ana3638_RS19535 ENOG410667J hydrolase Ana3638_RS19540 ENOG4105F1A Pyruvate formate-lyase Ana3638_RS19555 ENOG4105E5Q amino acid AbC transporter Ana3638_RS19560 ENOG4107R0W ABC transporter Ana3638_RS19570 ENOG4105F4P )-transporter Ana3638_RS19575 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Ana3638_RS19580 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Ana3638_RS19585 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Ana3638_RS19615 ENOG4105BZU Histidine kinase Ana3638_RS19620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Ana3638_RS19680 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Ana3638_RS19685 ENOG4107SJS nitrite reductase, (NAD(P)H) Ana3638_RS19690 ENOG4105CNW domain protein Ana3638_RS19700 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Ana3638_RS19725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ana3638_RS19730 ENOG4105XZU Preprotein translocase, subunit SecG Ana3638_RS19735 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Ana3638_RS19740 ENOG4105CP7 Triose-phosphate isomerase Ana3638_RS19765 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Ana3638_RS19770 ENOG4107QQR Sporulation Ana3638_RS19780 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Ana3638_RS19785 ENOG41067QW Transcriptional regulator Ana3638_RS19800 ENOG4105XJC Two component transcriptional regulator (Winged helix family Ana3638_RS19805 ENOG4105BZU Histidine kinase Ana3638_RS19810 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Ana3638_RS19815 ENOG4105BZU Histidine kinase Ana3638_RS19820 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS19825 ENOG4108V3W Chemotaxis protein, CheW Ana3638_RS19830 ENOG4105CBS Chea signal transduction histidine kinase Ana3638_RS19835 ENOG4107YTP response regulator receiver protein Ana3638_RS19860 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Ana3638_RS19865 ENOG4105E09 nadh pyrophosphatase Ana3638_RS19885 ENOG4105CDY transcriptional regulatory protein Ana3638_RS19890 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Ana3638_RS19895 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Ana3638_RS19900 ENOG4105DX0 Hemolysin A Ana3638_RS19905 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Ana3638_RS19915 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Ana3638_RS19920 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Ana3638_RS19925 ENOG4105M7K Involved in the transcription termination process (By similarity) Ana3638_RS19930 ENOG4108ZSR alkaline shock protein Ana3638_RS19945 ENOG410644B Stage III sporulation protein af Ana3638_RS19970 ENOG4105CD2 stage iii sporulation protein aa Ana3638_RS19975 ENOG4105E2X shikimate dehydrogenase Ana3638_RS19985 ENOG4105EEM helicase Ana3638_RS19990 ENOG4105CY0 Metallo-Beta-Lactamase Ana3638_RS20000 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Ana3638_RS20005 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Ana3638_RS20010 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Ana3638_RS20015 ENOG4105DND Transcriptional regulator Ana3638_RS20025 ENOG4105CEN a g-specific adenine glycosylase Ana3638_RS20030 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Ana3638_RS20035 ENOG4108ZP8 Acetolactate synthase small subunit Ana3638_RS20040 ENOG4107QRS glycosyltransferase group 2 family protein Ana3638_RS20045 ENOG4108KBE Glycosyl transferase, family 2 Ana3638_RS20050 ENOG4105C0H protease Ana3638_RS20070 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Ana3638_RS20075 ENOG4105EEI dihydropteroate synthase Ana3638_RS20080 ENOG4105EUJ GTP cyclohydrolase i Ana3638_RS20085 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Ana3638_RS20090 ENOG4105DR4 Methyltransferase Ana3638_RS20135 ENOG4105CJ1 ABC, transporter Ana3638_RS20140 ENOG4105BZU Histidine kinase Ana3638_RS20145 ENOG4105WH1 Two component transcriptional regulator luxr family Ana3638_RS20150 ENOG4108JQ7 (ABC) transporter Ana3638_RS20160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS20170 ENOG4105HJK ABC transporter Ana3638_RS20205 ENOG4108IG5 Transcriptional regulator Ana3638_RS20220 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Ana3638_RS20235 ENOG4108JQ7 (ABC) transporter Ana3638_RS20240 ENOG4105C3U ABC transporter Ana3638_RS20245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS20260 ENOG4105CQ4 Transcriptional regulator Ana3638_RS20320 ENOG4105CNN ABC, transporter Ana3638_RS20325 ENOG4105C2J ABC transporter Ana3638_RS20335 ENOG4105C2J ABC transporter Ana3638_RS20340 ENOG4105C2F Histidine kinase Ana3638_RS20345 ENOG4105EQD regulatoR Ana3638_RS20450 ENOG4105C37 (CBS) domain Ana3638_RS20465 ENOG4105NAE bifunctional deaminase-reductase domain protein Ana3638_RS20560 ENOG4107T14 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Ana3638_RS20570 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Ana3638_RS20600 ENOG4105CKK Glycosyl transferase, family 2 Ana3638_RS20605 ENOG4105EJV Membrane Ana3638_RS20610 ENOG4107ZE5 PPIases accelerate the folding of proteins Ana3638_RS20615 ENOG4105DC7 peptidase M24 Ana3638_RS20620 ENOG4105C28 cystathionine Ana3638_RS20660 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Ana3638_RS20665 ENOG4105CK5 oxidoreductase Ana3638_RS20675 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF Ana3638_RS20685 ENOG4108X8W Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Ana3638_RS20690 ENOG4105CKK Glycosyl transferase, family 2 Ana3638_RS20695 ENOG4105D7B Flagellar biosynthesis protein flha Ana3638_RS20715 ENOG4108X4Q Hydrolase Ana3638_RS20730 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Ana3638_RS20810 ENOG4105DVF Cytosine-specific methyltransferase Ana3638_RS20840 ENOG4108IMY Transcriptional regulator Ana3638_RS20900 ENOG4108I0C methyltransferase Ana3638_RS20915 ENOG4105D3R alkyl hydroperoxide reductase Ana3638_RS20940 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Ana3638_RS20960 ENOG4108MYC UTP-glucose-1-phosphate uridylyltransferase Ana3638_RS20970 ENOG4105DB7 PHP domain protein Ana3638_RS21015 ENOG4105C2F Histidine kinase Ana3638_RS21050 ENOG4105CJ1 ABC, transporter Ana3638_RS21055 ENOG4107SWG transcriptional regulator MERR family Ana3638_RS21105 ENOG4105DRS transport system, permease Ana3638_RS21110 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Ana3638_RS21120 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS21130 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Ana3638_RS21140 ENOG4105I03 Flagellin Ana3638_RS21200 ENOG4105W4W Transcriptional regulator Ana3638_RS21210 ENOG4105BZ1 (ABC) transporter Ana3638_RS21240 ENOG4105CJ1 ABC, transporter Ana3638_RS21245 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS21275 ENOG4105BZU Histidine kinase Ana3638_RS21280 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Ana3638_RS21285 ENOG4105E8R UPF0173 metal-dependent hydrolase Ana3638_RS21295 ENOG4108PZW LysR family Transcriptional regulator Ana3638_RS21305 ENOG4105CPC Aldo Keto reductase Ana3638_RS21315 ENOG4105VRS hydrolase family 18 Ana3638_RS21390 ENOG4105C2F Histidine kinase Ana3638_RS21405 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS21420 ENOG4105CJQ hydrolase, family 31 Ana3638_RS21425 ENOG4105BZU Histidine kinase Ana3638_RS21430 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin Ana3638_RS21435 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Ana3638_RS21480 ENOG4108JQ7 (ABC) transporter Ana3638_RS21485 ENOG4105C3U ABC transporter Ana3638_RS21490 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Ana3638_RS21520 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Ana3638_RS21530 ENOG4105KT7 mgtC SapB transporter Ana3638_RS21540 ENOG4105CM2 brancheD-chain amino acid aminotransferase Ana3638_RS21550 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Ana3638_RS21580 ENOG4105C2F Histidine kinase Ana3638_RS21585 ENOG4105WH1 Two component transcriptional regulator luxr family Ana3638_RS21595 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) Ana3638_RS21605 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase Ana3638_RS21645 ENOG4105D9R oxidoreductase Ana3638_RS21650 ENOG4107QP6 Xylose isomerase domain protein TIM barrel Ana3638_RS21655 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) Ana3638_RS21680 ENOG4105C85 amino acid Ana3638_RS21695 ENOG4105DUM transcriptional regulator, lysR family Ana3638_RS21715 ENOG4105DRS transport system, permease Ana3638_RS21720 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS21725 ENOG4108IJ9 (ABC) transporter Ana3638_RS21735 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Ana3638_RS21745 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Ana3638_RS21750 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Ana3638_RS21755 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Ana3638_RS21770 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) Ana3638_RS21785 ENOG4105CHR reductase Ana3638_RS21790 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Ana3638_RS21800 ENOG4108HHA Transketolase Ana3638_RS21805 ENOG4105JXH GntR family transcriptional regulator Ana3638_RS21815 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ana3638_RS21820 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS21825 ENOG410769Z extracellular solute-binding protein family 1 Ana3638_RS21855 ENOG4105EQD regulatoR Ana3638_RS21860 ENOG4105EEM helicase Ana3638_RS21905 ENOG41085FC arsR family transcriptional regulator Ana3638_RS21910 ENOG4105F0V Cell wall hydrolase Ana3638_RS21915 ENOG4105K4H Nlp p60 protein Ana3638_RS21960 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase Ana3638_RS21965 ENOG4105KVH Transcriptional regulator Ana3638_RS21970 ENOG4108HWW ABC transporter Ana3638_RS21980 ENOG4105DFW ABC transporter Ana3638_RS21985 ENOG4105DFW ABC transporter Ana3638_RS21990 ENOG4105EQD regulatoR Ana3638_RS21995 ENOG4105C2F Histidine kinase Ana3638_RS22010 ENOG4105C10 Electron transfer flavoprotein Ana3638_RS22015 ENOG4105BZJ Electron transfer flavoprotein Ana3638_RS22055 ENOG4105E2V Glycosyltransferase 36 Ana3638_RS22060 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Ana3638_RS22075 ENOG4108HRK Histidine kinase Ana3638_RS22090 ENOG4108K2B transcriptional regulator Ana3638_RS22095 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Ana3638_RS22120 ENOG4105DME alpha-galactosidase Ana3638_RS22140 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS22145 ENOG4107FKK extracellular solute-binding protein family 1 Ana3638_RS22150 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein Ana3638_RS22160 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Ana3638_RS22170 ENOG4107QIZ NADH dehydrogenase Ana3638_RS22175 ENOG4107QHI -hydrogenase Ana3638_RS22180 ENOG4105Y5S NADH ubiquinone oxidoreductase, 24 kD Ana3638_RS22200 ENOG4105D9Q decarboxylase (Beta subunit) Ana3638_RS22215 ENOG4105CGH 5'-nucleotidase Ana3638_RS22230 ENOG4105PAD Hydrolase Ana3638_RS22265 ENOG4105DRS transport system, permease Ana3638_RS22280 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS22285 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Ana3638_RS22310 ENOG4105CNG UPF0061 protein Ana3638_RS22330 ENOG4105CHR reductase Ana3638_RS22345 ENOG41062B0 ABC transporter, permease Ana3638_RS22350 ENOG4107R9N ABC transporter Ana3638_RS22355 ENOG4105C2J ABC transporter Ana3638_RS22365 ENOG4105C2F Histidine kinase Ana3638_RS22370 ENOG41075H3 AraC family transcriptional regulator Ana3638_RS22375 ENOG4105EQD regulatoR Ana3638_RS22390 ENOG4105EJ2 Transcriptional regulator Ana3638_RS22400 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) Ana3638_RS22420 ENOG4105D7W serine acetyltransferase Ana3638_RS22465 ENOG41086DT Membrane protein of unknown function Ana3638_RS22485 ENOG4108UIN ybak prolyl-trna synthetase associated region Ana3638_RS22495 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Ana3638_RS22500 ENOG4108IJ0 Aspartate ammonia-lyase Ana3638_RS22505 ENOG41086D8 Transcriptional regulator Ana3638_RS22525 ENOG4107BJW polysaccharide deacetylase Ana3638_RS22530 ENOG4105DU1 integral membrane protein, terc Ana3638_RS22550 ENOG41086D8 Transcriptional regulator Ana3638_RS22560 ENOG4107SHJ sulfite reductase subunit b Ana3638_RS22565 ENOG4105D5B Sulfite reductase, subunit A Ana3638_RS22580 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Ana3638_RS22585 ENOG4107TXC Transcriptional regulator Ana3638_RS22615 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Ana3638_RS22620 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Ana3638_RS22630 ENOG4105C2F Histidine kinase Ana3638_RS22635 ENOG4105EQD regulatoR Ana3638_RS22640 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Ana3638_RS22655 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Ana3638_RS22665 ENOG41069DP small acid-soluble spore protein Ana3638_RS22675 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Ana3638_RS22690 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Ana3638_RS22710 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) Ana3638_RS22725 ENOG4108SGK Tetr family transcriptional regulator Ana3638_RS22740 ENOG4105CNT hydrolase family 2 Ana3638_RS22745 ENOG4105W4W Transcriptional regulator Ana3638_RS22760 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS22770 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS22785 ENOG4105ECQ AraC Family Transcriptional Regulator Ana3638_RS22795 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Ana3638_RS22800 ENOG4108UW5 maltose o-acetyltransferase Ana3638_RS22810 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS22825 ENOG4105CMG Carbohydrate kinase Ana3638_RS22835 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Ana3638_RS22860 ENOG4105EAM Na Pi-cotransporter Ana3638_RS22875 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS22890 ENOG4108MR6 WD40-like Beta Propeller Repeat Ana3638_RS22895 ENOG4107KJX Transcriptional regulator Ana3638_RS22910 ENOG4105CMR udp-glucose 4-epimerase Ana3638_RS22920 ENOG4105ETE Transcriptional regulator (LacI family Ana3638_RS22945 ENOG4105EQD regulatoR Ana3638_RS22950 ENOG4105C2F Histidine kinase Ana3638_RS22960 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS22975 ENOG4105C0D helicase Ana3638_RS23020 ENOG4105BZU Histidine kinase Ana3638_RS23030 ENOG4105KRQ Addiction module toxin, Txe YoeB family Ana3638_RS23100 ENOG4105UQX Mate efflux family protein Ana3638_RS23115 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Ana3638_RS23120 ENOG4106KNT transcriptional regulator Ana3638_RS23130 ENOG4105E0X reductase Ana3638_RS23135 ENOG4105EQD regulatoR Ana3638_RS23140 ENOG4105C2F Histidine kinase Ana3638_RS23145 ENOG4105C2F Histidine kinase Ana3638_RS23155 ENOG4105EF1 ribulokinase Ana3638_RS23160 ENOG4105CHR reductase Ana3638_RS23165 ENOG4105CNN ABC, transporter Ana3638_RS23170 ENOG4105C2J ABC transporter Ana3638_RS23175 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Ana3638_RS23180 ENOG4108ETY sodium dicarboxylate symporter Ana3638_RS23220 ENOG4108Z6Z Transcriptional regulator Ana3638_RS23255 ENOG4105DQE DNA ligase Ana3638_RS23260 ENOG4105FDF Could be involved in DNA repair (By similarity) Ana3638_RS23315 ENOG410904A RNA polymerase Ana3638_RS23330 ENOG4105VRS hydrolase family 18 Ana3638_RS23335 ENOG4105EQK -acetyltransferase Ana3638_RS23355 ENOG410823F Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) Ana3638_RS23360 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Ana3638_RS23365 ENOG4105BZU Histidine kinase Ana3638_RS23370 ENOG4108V3W Chemotaxis protein, CheW Ana3638_RS23380 ENOG4108V3W Chemotaxis protein, CheW Ana3638_RS23390 ENOG4108Z6X (sortase) family Ana3638_RS23420 ENOG41062ES Transcriptional regulator Ana3638_RS23430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS23435 ENOG4105CV8 reductase Ana3638_RS23440 ENOG4107U9B transcriptional regulator Ana3638_RS23465 ENOG4107SET aldo keto reductase Ana3638_RS23470 ENOG4105PDP Short chain dehydrogenase Ana3638_RS23475 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF Ana3638_RS23485 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Ana3638_RS23515 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Ana3638_RS23520 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Ana3638_RS23530 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS23540 ENOG4105JAB phenazine biosynthesis protein, phzf family Ana3638_RS23550 ENOG4105WH1 Two component transcriptional regulator luxr family Ana3638_RS23555 ENOG4105BZU Histidine kinase Ana3638_RS23600 ENOG4105JQZ Methyltransferase Ana3638_RS23610 ENOG4105DND Transcriptional regulator Ana3638_RS23620 ENOG4108KGH TRANSCRIPTIONal Ana3638_RS23685 ENOG4107V2S Transcriptional regulator Ana3638_RS23690 ENOG4107V2S Transcriptional regulator Ana3638_RS23740 ENOG41086D8 Transcriptional regulator Ana3638_RS23755 ENOG4105RHY Pfam:UPF0157 Ana3638_RS23815 ENOG4105XSJ toxin secretion phage lysis holin Ana3638_RS23890 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Ana3638_RS23895 ENOG4105EFC phage portal protein HK97 family Ana3638_RS23900 ENOG4105CAR Terminase, large subunit Ana3638_RS23920 ENOG4107V6I Cytosine-specific methyltransferase Ana3638_RS23925 ENOG4108ES9 ParB domain protein nuclease Ana3638_RS23985 ENOG4105C2M dna polymerase I Ana3638_RS24030 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Ana3638_RS24035 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS24040 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Ana3638_RS24045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Ana3638_RS24090 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Ana3638_RS24110 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Ana3638_RS24115 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Ana3638_RS24120 ENOG4105BZ1 (ABC) transporter Ana3638_RS24140 ENOG41067QW Transcriptional regulator Ana3638_RS24170 ENOG41067MG lrgb family Ana3638_RS24180 ENOG4105C8Q Methyl-accepting chemotaxis Ana3638_RS24210 ENOG4105F8D glycoside hydrolase family 4 Ana3638_RS24215 ENOG4108RVA ribokinase Ana3638_RS24220 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Ana3638_RS24240 ENOG4105EQD regulatoR Ana3638_RS24260 ENOG4105CHH sulfate transporter Ana3638_RS24310 ENOG41086D8 Transcriptional regulator Ana3638_RS24315 ENOG4107RBB ABC transporter, permease Ana3638_RS24320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ana3638_RS24325 ENOG4105BZU Histidine kinase Ana3638_RS24335 ENOG4105E09 nadh pyrophosphatase Ana3638_RS24350 ENOG4105UEI Transcriptional Regulator AraC Family Ana3638_RS24360 ENOG4105CJ1 ABC, transporter Ana3638_RS24375 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Ana3638_RS24390 ENOG4105DCG PHP domain protein Ana3638_RS24400 ENOG4108YM7 Gcn5-related n-acetyltransferase Ana3638_RS24415 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Ana3638_RS24430 ENOG4105KNA -acetyltransferase Ana3638_RS24440 ENOG4107T8T UPF0173 metal-dependent hydrolase Ana3638_RS24445 ENOG4105C5H ABC transporter Ana3638_RS24450 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Ana3638_RS24465 ENOG4105KRS Proteinase inhibitor Ana3638_RS24495 ENOG4105EK5 Glycoside hydrolase family 8 Ana3638_RS24510 ENOG4105DME alpha-galactosidase