locus-tag	class	description
STSP2_RS00020	COG0148	phosphopyruvate hydratase activity
STSP2_RS00040	COG0688	phosphatidylethanolamine metabolic process
STSP2_RS00065	COG2201	protein-glutamate methylesterase activity
STSP2_RS00070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
STSP2_RS00080	COG2198	Histidine kinase
STSP2_RS00080	COG0643	Histidine kinase
STSP2_RS00085	COG0529	Catalyzes the synthesis of activated sulfate
STSP2_RS00090	COG0175	sulfate reduction
STSP2_RS00100	COG0457	Tetratricopeptide repeat
STSP2_RS00105	COG1516	flagellar protein fliS
STSP2_RS00150	COG1677	Flagellar hook-basal body complex protein FliE
STSP2_RS00155	COG1766	The M ring may be actively involved in energy transduction
STSP2_RS00170	COG1157	protein secretion by the type III secretion system
STSP2_RS00185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
STSP2_RS00190	COG1360	Flagellar Motor Protein
STSP2_RS00205	COG1338	Plays a role in the flagellum-specific transport system
STSP2_RS00215	COG1684	flagellar biosynthetic protein fliR
STSP2_RS00220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
STSP2_RS00225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
STSP2_RS00230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
STSP2_RS00230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
STSP2_RS00270	COG1706	bacterial-type flagellum-dependent cell motility
STSP2_RS00280	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
STSP2_RS00285	COG4786	Flagellar basal body rod
STSP2_RS00290	COG4786	Flagellar basal body rod
STSP2_RS00310	COG2204	response regulator
STSP2_RS00325	COG2204	response regulator
STSP2_RS00340	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
STSP2_RS00340	COG1776	CheC inhibitor of MCP methylation
STSP2_RS00345	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
STSP2_RS00395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
STSP2_RS00400	COG3119	arylsulfatase activity
STSP2_RS00410	COG0569	domain protein
STSP2_RS00420	COG1047	Peptidyl-prolyl cis-trans
STSP2_RS00425	COG2755	lipolytic protein G-D-S-L family
STSP2_RS00425	COG0657	acetylesterase activity
STSP2_RS00430	COG0657	acetylesterase activity
STSP2_RS00430	COG2755	lipolytic protein G-D-S-L family
STSP2_RS00440	COG0823	Involved in the tonB-independent uptake of proteins
STSP2_RS00470	COG2095	MarC family integral membrane protein
STSP2_RS00475	COG2813	Specifically methylates the guanine in position
STSP2_RS00475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
STSP2_RS00485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
STSP2_RS00500	COG0698	ribose 5-phosphate isomerase
STSP2_RS00510	COG1475	DNA binding
STSP2_RS00520	COG1136	(ABC) transporter
STSP2_RS00565	COG0673	inositol 2-dehydrogenase activity
STSP2_RS00575	COG0628	permease
STSP2_RS00590	COG3119	arylsulfatase activity
STSP2_RS00595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STSP2_RS00625	COG3119	arylsulfatase activity
STSP2_RS00655	COG0730	response to heat
STSP2_RS00680	COG3335	DDE superfamily endonuclease
STSP2_RS00690	COG4251	negative regulation of phosphorylation
STSP2_RS00705	COG1199	ATP-dependent helicase activity
STSP2_RS00715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
STSP2_RS00720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
STSP2_RS00735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
STSP2_RS00765	COG0864	Transcriptional regulator
STSP2_RS00785	COG0348	domain, Protein
STSP2_RS00790	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
STSP2_RS00800	COG3119	arylsulfatase activity
STSP2_RS00810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
STSP2_RS00815	COG1192	Involved in chromosome partitioning
STSP2_RS00820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
STSP2_RS00850	COG5002	protein histidine kinase activity
STSP2_RS00850	COG3447	MASE1 domain protein
STSP2_RS00850	COG5001	Diguanylate cyclase
STSP2_RS00860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STSP2_RS00870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
STSP2_RS00935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
STSP2_RS00945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
STSP2_RS00995	COG0151	Belongs to the GarS family
STSP2_RS01040	COG0772	Belongs to the SEDS family
STSP2_RS01060	COG0443	Heat shock 70 kDa protein
STSP2_RS01065	COG3869	Catalyzes the specific phosphorylation of arginine residues in
STSP2_RS01095	COG3177	Filamentation induced by cAMP protein fic
STSP2_RS01100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
STSP2_RS01110	COG0235	Class ii aldolase
STSP2_RS01130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
STSP2_RS01135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
STSP2_RS01140	COG0459	protein refolding
STSP2_RS01170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STSP2_RS01175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STSP2_RS01185	COG1278	Cold shock
STSP2_RS01280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
STSP2_RS01285	COG4251	negative regulation of phosphorylation
STSP2_RS01290	COG1454	alcohol dehydrogenase
STSP2_RS01305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
STSP2_RS01315	COG3209	COG3209 Rhs family protein
STSP2_RS01325	COG3209	COG3209 Rhs family protein
STSP2_RS01340	COG1355	regulation of microtubule-based process
STSP2_RS01345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
STSP2_RS01350	COG1192	Involved in chromosome partitioning
STSP2_RS01355	COG1349	DNA-binding transcription factor activity
STSP2_RS01385	COG0798	PFAM Bile acid sodium symporter
STSP2_RS01390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
STSP2_RS01405	COG1522	sequence-specific DNA binding
STSP2_RS01420	COG1051	belongs to the nudix hydrolase family
STSP2_RS01425	COG2081	HI0933 family
STSP2_RS01435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
STSP2_RS01445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
STSP2_RS01450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
STSP2_RS01510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
STSP2_RS01515	COG0569	domain protein
STSP2_RS01520	COG0561	phosphatase activity
STSP2_RS01525	COG4251	negative regulation of phosphorylation
STSP2_RS01530	COG0564	pseudouridine synthase activity
STSP2_RS01555	COG4191	Histidine kinase
STSP2_RS01560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
STSP2_RS01570	COG3645	SOS response
STSP2_RS01580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STSP2_RS01650	COG1611	Belongs to the LOG family
STSP2_RS01675	COG1360	Flagellar Motor Protein
STSP2_RS01705	COG3681	Belongs to the UPF0597 family
STSP2_RS01725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
STSP2_RS01730	COG1605	Chorismate mutase
STSP2_RS01730	COG0077	Prephenate dehydratase
STSP2_RS01735	COG0149	triose-phosphate isomerase activity
STSP2_RS01745	COG1561	YicC-like family, N-terminal region
STSP2_RS01750	COG0194	GDP metabolic process
STSP2_RS01755	COG1758	RNA polymerase activity
STSP2_RS01760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
STSP2_RS01765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
STSP2_RS01780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
STSP2_RS01780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
STSP2_RS01785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
STSP2_RS01800	COG3119	arylsulfatase activity
STSP2_RS01805	COG3345	alpha-galactosidase
STSP2_RS01865	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
STSP2_RS01870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
STSP2_RS01920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
STSP2_RS01925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
STSP2_RS01930	COG0667	Aldo Keto reductase
STSP2_RS01945	COG0492	ferredoxin-NADP+ reductase activity
STSP2_RS01960	COG1475	DNA binding
STSP2_RS01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
STSP2_RS01985	COG2095	MarC family integral membrane protein
STSP2_RS01995	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
STSP2_RS02000	COG1074	ATP-dependent DNA helicase activity
STSP2_RS02005	COG0205	6-phosphofructokinase activity
STSP2_RS02030	COG0552	protein localization to endoplasmic reticulum
STSP2_RS02045	COG0071	Belongs to the small heat shock protein (HSP20) family
STSP2_RS02055	COG2205	protein histidine kinase activity
STSP2_RS02055	COG4999	Histidine kinase
STSP2_RS02055	COG3850	Histidine kinase
STSP2_RS02055	COG3437	response regulator, receiver
STSP2_RS02065	COG4771	TonB-dependent receptor
STSP2_RS02090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
STSP2_RS02100	COG2165	general secretion pathway protein
STSP2_RS02105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
STSP2_RS02110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
STSP2_RS02115	COG0066	3-isopropylmalate dehydratase activity
STSP2_RS02120	COG0473	3-isopropylmalate dehydrogenase activity
STSP2_RS02125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STSP2_RS02150	COG1119	ATPase activity
STSP2_RS02160	COG3119	arylsulfatase activity
STSP2_RS02165	COG1160	GTP binding
STSP2_RS02170	COG1966	Carbon starvation protein
STSP2_RS02180	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
STSP2_RS02195	COG0488	(ABC) transporter
STSP2_RS02210	COG0187	DNA topoisomerase II activity
STSP2_RS02225	COG1674	ftsk spoiiie
STSP2_RS02225	COG4980	gas vesicle protein
STSP2_RS02235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STSP2_RS02240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
STSP2_RS02270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
STSP2_RS02275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
STSP2_RS02285	COG0193	aminoacyl-tRNA hydrolase activity
STSP2_RS02290	COG0360	Binds together with S18 to 16S ribosomal RNA
STSP2_RS02295	COG0629	single-stranded DNA binding
STSP2_RS02300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
STSP2_RS02305	COG0359	binds to the 23S rRNA
STSP2_RS02310	COG0305	Participates in initiation and elongation during chromosome replication
STSP2_RS02330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
STSP2_RS02330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STSP2_RS02335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
STSP2_RS02350	COG1515	deoxyribonuclease V activity
STSP2_RS02355	COG3119	arylsulfatase activity
STSP2_RS02360	COG3119	arylsulfatase activity
STSP2_RS02365	COG3119	arylsulfatase activity
STSP2_RS02375	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
STSP2_RS02400	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
STSP2_RS02405	COG0028	Belongs to the TPP enzyme family
STSP2_RS02410	COG0440	acetolactate synthase activity
STSP2_RS02415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
STSP2_RS02430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
STSP2_RS02435	COG0501	Belongs to the peptidase M48B family
STSP2_RS02445	COG4656	Part of a membrane complex involved in electron transport
STSP2_RS02450	COG4658	electron transport chain
STSP2_RS02460	COG4660	Part of a membrane complex involved in electron transport
STSP2_RS02465	COG4657	Part of a membrane complex involved in electron transport
STSP2_RS02470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
STSP2_RS02480	COG0706	membrane insertase activity
STSP2_RS02545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
STSP2_RS02555	COG0268	Binds directly to 16S ribosomal RNA
STSP2_RS02560	COG0557	exoribonuclease II activity
STSP2_RS02565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
STSP2_RS02575	COG0653	protein targeting
STSP2_RS02620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
STSP2_RS02650	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
STSP2_RS02680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STSP2_RS02685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
STSP2_RS02690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
STSP2_RS02695	COG2208	phosphoserine phosphatase activity
STSP2_RS02700	COG1254	Belongs to the acylphosphatase family
STSP2_RS02705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STSP2_RS02710	COG0673	inositol 2-dehydrogenase activity
STSP2_RS02720	COG5492	domain, Protein
STSP2_RS02725	COG0667	Aldo Keto reductase
STSP2_RS02735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
STSP2_RS02740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STSP2_RS02745	COG2022	thiamine diphosphate biosynthetic process
STSP2_RS02755	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
STSP2_RS02760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
STSP2_RS02765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
STSP2_RS02770	COG0673	inositol 2-dehydrogenase activity
STSP2_RS02775	COG3622	Belongs to the hyi family
STSP2_RS02790	COG1012	belongs to the aldehyde dehydrogenase family
STSP2_RS02815	COG3335	DDE superfamily endonuclease
STSP2_RS02830	COG1785	Belongs to the alkaline phosphatase family
STSP2_RS02835	COG3209	COG3209 Rhs family protein
STSP2_RS02845	COG3209	COG3209 Rhs family protein
STSP2_RS02860	COG0542	response to heat
STSP2_RS02870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STSP2_RS02875	COG5012	cobalamin binding
STSP2_RS02880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
STSP2_RS02885	COG3250	beta-galactosidase activity
STSP2_RS02915	COG0405	Gamma-glutamyltransferase
STSP2_RS02940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
STSP2_RS02945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
STSP2_RS02955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
STSP2_RS02990	COG0322	excinuclease ABC activity
STSP2_RS03030	COG0584	glycerophosphoryl diester phosphodiesterase
STSP2_RS03035	COG0105	UTP biosynthetic process
STSP2_RS03050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STSP2_RS03060	COG1278	Cold shock
STSP2_RS03070	COG1278	Cold shock
STSP2_RS03075	COG2070	2-Nitropropane dioxygenase
STSP2_RS03085	COG3335	DDE superfamily endonuclease
STSP2_RS03110	COG3335	DDE superfamily endonuclease
STSP2_RS03160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
STSP2_RS03175	COG0513	Belongs to the DEAD box helicase family
STSP2_RS03190	COG0840	transmembrane signaling receptor activity
STSP2_RS03200	COG4251	negative regulation of phosphorylation
STSP2_RS03205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
STSP2_RS03210	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
STSP2_RS03220	COG0018	arginyl-trna synthetase
STSP2_RS03225	COG0432	Pfam Uncharacterised protein family UPF0047
STSP2_RS03240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
STSP2_RS03245	COG2201	protein-glutamate methylesterase activity
STSP2_RS03250	COG0745	RESPONSE REGULATOR receiver
STSP2_RS03270	COG0439	Biotin carboxylase
STSP2_RS03275	COG0511	ligase activity, forming carbon-carbon bonds
STSP2_RS03280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
STSP2_RS03280	COG0646	methionine synthase
STSP2_RS03300	COG0019	diaminopimelate decarboxylase activity
STSP2_RS03315	COG0375	protein maturation
STSP2_RS03320	COG0309	Hydrogenase expression formation protein (HypE)
STSP2_RS03325	COG0409	Hydrogenase expression formation protein
STSP2_RS03330	COG0298	carbon dioxide binding
STSP2_RS03335	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
STSP2_RS03350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
STSP2_RS03375	COG0542	response to heat
STSP2_RS03390	COG1297	OPT oligopeptide transporter protein
STSP2_RS03395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
STSP2_RS03405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STSP2_RS03405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
STSP2_RS03410	COG1774	PSP1 C-terminal conserved region
STSP2_RS03420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
STSP2_RS03460	COG0481	GTPase activity
STSP2_RS03470	COG3119	arylsulfatase activity
STSP2_RS03475	COG3119	arylsulfatase activity
STSP2_RS03480	COG0534	Mate efflux family protein
STSP2_RS03485	COG1929	Belongs to the glycerate kinase type-1 family
STSP2_RS03490	COG3119	arylsulfatase activity
STSP2_RS03500	COG3119	arylsulfatase activity
STSP2_RS03510	COG0598	Magnesium transport protein CorA
STSP2_RS03515	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
STSP2_RS03545	COG3119	arylsulfatase activity
STSP2_RS03550	COG3250	beta-galactosidase activity
STSP2_RS03595	COG0667	Aldo Keto reductase
STSP2_RS03605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
STSP2_RS03605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
STSP2_RS03615	COG0671	phosphoesterase, PA-phosphatase related
STSP2_RS03620	COG0110	maltose O-acetyltransferase activity
STSP2_RS03650	COG0129	dihydroxy-acid dehydratase activity
STSP2_RS03670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
STSP2_RS03680	COG1968	undecaprenyl-diphosphatase activity
STSP2_RS03700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
STSP2_RS03705	COG0575	Belongs to the CDS family
STSP2_RS03710	COG1702	phosphate starvation-inducible protein PhoH
STSP2_RS03715	COG1480	7TM receptor with intracellular HD hydrolase
STSP2_RS03740	COG2255	four-way junction helicase activity
STSP2_RS03745	COG0632	four-way junction helicase activity
STSP2_RS03750	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
STSP2_RS03755	COG0215	cysteine-tRNA ligase activity
STSP2_RS03760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
STSP2_RS03765	COG0131	Imidazoleglycerol-phosphate dehydratase
STSP2_RS03770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
STSP2_RS03775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
STSP2_RS03780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
STSP2_RS03785	COG0126	phosphoglycerate kinase activity
STSP2_RS03810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
STSP2_RS03830	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
STSP2_RS03840	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
STSP2_RS03855	COG0772	Belongs to the SEDS family
STSP2_RS03860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
STSP2_RS03875	COG0442	prolyl-tRNA aminoacylation
STSP2_RS03885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STSP2_RS03895	COG3119	arylsulfatase activity
STSP2_RS03900	COG0217	transcriptional regulatory protein
STSP2_RS03905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
STSP2_RS03920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
STSP2_RS03920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
STSP2_RS03925	COG0195	Participates in both transcription termination and antitermination
STSP2_RS03935	COG0284	orotidine-5'-phosphate decarboxylase activity
STSP2_RS03940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
STSP2_RS03970	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
STSP2_RS03975	COG0539	negative regulation of cytoplasmic translation
STSP2_RS03975	COG2183	response to ionizing radiation
STSP2_RS03985	COG4221	oxidoreductase activity
STSP2_RS04015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
STSP2_RS04025	COG3119	arylsulfatase activity
STSP2_RS04030	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
STSP2_RS04035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STSP2_RS04050	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
STSP2_RS04065	COG0010	Belongs to the arginase family
STSP2_RS04070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
STSP2_RS04075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
STSP2_RS04120	COG1151	hydroxylamine reductase activity
STSP2_RS04130	COG1959	2 iron, 2 sulfur cluster binding
STSP2_RS04155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
STSP2_RS04160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
STSP2_RS04170	COG1607	acyl-coa hydrolase
STSP2_RS04175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
STSP2_RS04190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STSP2_RS04195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
STSP2_RS04200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
STSP2_RS04235	COG0667	Aldo Keto reductase
STSP2_RS04260	COG2226	methyltransferase
STSP2_RS04265	COG0181	hydroxymethylbilane synthase activity
STSP2_RS04270	COG1522	sequence-specific DNA binding
STSP2_RS04280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
STSP2_RS04285	COG0535	radical SAM domain protein
STSP2_RS04290	COG0535	radical SAM domain protein
STSP2_RS04295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
STSP2_RS04310	COG1522	sequence-specific DNA binding
STSP2_RS04320	COG0113	porphobilinogen synthase activity
STSP2_RS04325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
STSP2_RS04330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
STSP2_RS04355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
STSP2_RS04360	COG0254	rRNA binding
STSP2_RS04385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
STSP2_RS04390	COG0302	gtp cyclohydrolase
STSP2_RS04400	COG2201	protein-glutamate methylesterase activity
STSP2_RS04410	COG3850	Histidine kinase
STSP2_RS04410	COG3437	response regulator, receiver
STSP2_RS04410	COG2205	protein histidine kinase activity
STSP2_RS04410	COG4999	Histidine kinase
STSP2_RS04415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STSP2_RS04440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
STSP2_RS04470	COG2095	MarC family integral membrane protein
STSP2_RS04475	COG1361	Conserved repeat domain
STSP2_RS04485	COG0668	transmembrane transport
STSP2_RS04490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STSP2_RS04500	COG4251	negative regulation of phosphorylation
STSP2_RS04515	COG0446	pyridine nucleotide-disulphide oxidoreductase
STSP2_RS04525	COG1335	isochorismatase
STSP2_RS04530	COG1032	radical SAM domain protein
STSP2_RS04555	COG2226	methyltransferase
STSP2_RS04565	COG0535	radical SAM domain protein
STSP2_RS04635	COG3940	Belongs to the glycosyl hydrolase 43 family
STSP2_RS04675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
STSP2_RS04695	COG0107	imidazoleglycerol-phosphate synthase activity
STSP2_RS04770	COG3344	reverse transcriptase
STSP2_RS04775	COG3328	transposase activity
STSP2_RS04845	COG4175	Glycine betaine
STSP2_RS04845	COG0517	IMP dehydrogenase activity
STSP2_RS04870	COG1408	metallophosphoesterase
STSP2_RS04900	COG0835	chemotaxis
STSP2_RS04905	COG0840	transmembrane signaling receptor activity
STSP2_RS04910	COG0784	Response regulator, receiver
STSP2_RS04910	COG2205	protein histidine kinase activity
STSP2_RS05000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
STSP2_RS05005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
STSP2_RS05015	COG0175	sulfate reduction
STSP2_RS05020	COG0175	sulfate reduction
STSP2_RS05030	COG1959	2 iron, 2 sulfur cluster binding
STSP2_RS05085	COG2270	Major facilitator Superfamily
STSP2_RS05110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
STSP2_RS05135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
STSP2_RS05170	COG1061	Type III restriction enzyme res subunit
STSP2_RS05185	COG1475	DNA binding
STSP2_RS05190	COG3654	unkown
STSP2_RS05355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
STSP2_RS05380	COG0515	serine threonine protein kinase
STSP2_RS05405	COG0833	amino acid
STSP2_RS05425	COG2033	superoxide reductase activity
STSP2_RS05430	COG1305	Transglutaminase-like
STSP2_RS05455	COG0657	acetylesterase activity
STSP2_RS05455	COG2755	lipolytic protein G-D-S-L family
STSP2_RS05460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
STSP2_RS05460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
STSP2_RS05475	COG3119	arylsulfatase activity
STSP2_RS05480	COG0673	inositol 2-dehydrogenase activity
STSP2_RS05500	COG3104	oligopeptide transport
STSP2_RS05515	COG3525	Glycosyl hydrolase, family 20, catalytic domain
STSP2_RS05520	COG0673	inositol 2-dehydrogenase activity
STSP2_RS05530	COG3250	beta-galactosidase activity
STSP2_RS05535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
STSP2_RS05545	COG0859	PFAM glycosyl transferase family 9
STSP2_RS05570	COG1269	ATP hydrolysis coupled proton transport
STSP2_RS05575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STSP2_RS05595	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
STSP2_RS05600	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
STSP2_RS05605	COG1394	ATPase activity, coupled to movement of substances
STSP2_RS05630	COG0534	Mate efflux family protein
STSP2_RS05775	COG4589	Belongs to the CDS family
STSP2_RS05780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
STSP2_RS05785	COG0574	Belongs to the PEP-utilizing enzyme family
STSP2_RS05785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STSP2_RS05795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
STSP2_RS05810	COG4974	Belongs to the 'phage' integrase family
STSP2_RS05820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
STSP2_RS05935	COG3119	arylsulfatase activity
STSP2_RS05985	COG2165	general secretion pathway protein
STSP2_RS05990	COG3119	arylsulfatase activity
STSP2_RS05990	COG3408	Glycogen debranching enzyme
STSP2_RS05995	COG3408	Glycogen debranching enzyme
STSP2_RS06000	COG3119	arylsulfatase activity
STSP2_RS06000	COG3408	Glycogen debranching enzyme
STSP2_RS06055	COG3119	arylsulfatase activity
STSP2_RS06055	COG3408	Glycogen debranching enzyme
STSP2_RS06080	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
STSP2_RS06115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
STSP2_RS06130	COG3335	DDE superfamily endonuclease
STSP2_RS06225	COG3525	Glycosyl hydrolase, family 20, catalytic domain
STSP2_RS06245	COG0673	inositol 2-dehydrogenase activity
STSP2_RS06250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
STSP2_RS06255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
STSP2_RS06255	COG0515	serine threonine protein kinase
STSP2_RS06270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
STSP2_RS06290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
STSP2_RS06295	COG0736	holo-[acyl-carrier-protein] synthase activity
STSP2_RS06300	COG0445	tRNA wobble uridine modification
STSP2_RS06305	COG2165	general secretion pathway protein
STSP2_RS06310	COG4968	Prepilin-type N-terminal cleavage methylation domain
STSP2_RS06315	COG1917	Cupin 2, conserved barrel domain protein
STSP2_RS06315	COG4977	sequence-specific DNA binding
STSP2_RS06320	COG0366	Alpha amylase catalytic
STSP2_RS06335	COG1506	peptidase
STSP2_RS06335	COG0823	Involved in the tonB-independent uptake of proteins
STSP2_RS06350	COG0204	Acyl-transferase
STSP2_RS06350	COG0318	PFAM AMP-dependent synthetase and ligase
STSP2_RS06365	COG2205	protein histidine kinase activity
STSP2_RS06375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS06380	COG1459	type II secretion system
STSP2_RS06455	COG4409	exo-alpha-(2->6)-sialidase activity
STSP2_RS06465	COG2205	protein histidine kinase activity
STSP2_RS06465	COG0784	Response regulator, receiver
STSP2_RS06470	COG0840	transmembrane signaling receptor activity
STSP2_RS06475	COG0835	chemotaxis
STSP2_RS06480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS06490	COG1595	DNA-templated transcription, initiation
STSP2_RS06500	COG3119	arylsulfatase activity
STSP2_RS06505	COG3119	arylsulfatase activity
STSP2_RS06510	COG3119	arylsulfatase activity
STSP2_RS06540	COG3901	Regulator of nitric oxide reductase transcription
STSP2_RS06540	COG0348	domain, Protein
STSP2_RS06550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
STSP2_RS06575	COG0709	Synthesizes selenophosphate from selenide and ATP
STSP2_RS06580	COG1924	4 iron, 4 sulfur cluster binding
STSP2_RS06595	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
STSP2_RS06600	COG2226	methyltransferase
STSP2_RS06650	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
STSP2_RS06670	COG0732	type I restriction modification DNA specificity domain
STSP2_RS06680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
STSP2_RS06755	COG0582	viral genome integration into host DNA
STSP2_RS06765	COG2255	four-way junction helicase activity
STSP2_RS06840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
STSP2_RS06845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
STSP2_RS06855	COG3119	arylsulfatase activity
STSP2_RS06865	COG3250	beta-galactosidase activity
STSP2_RS06880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
STSP2_RS06885	COG2205	protein histidine kinase activity
STSP2_RS06915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STSP2_RS06920	COG0745	RESPONSE REGULATOR receiver
STSP2_RS06930	COG1160	GTP binding
STSP2_RS06955	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STSP2_RS06980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
STSP2_RS07015	COG0495	leucyl-tRNA aminoacylation
STSP2_RS07025	COG1597	lipid kinase activity
STSP2_RS07030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
STSP2_RS07035	COG0731	radical SAM domain protein
STSP2_RS07035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STSP2_RS07045	COG4974	Belongs to the 'phage' integrase family
STSP2_RS07050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STSP2_RS07055	COG2195	Cleaves the N-terminal amino acid of tripeptides
STSP2_RS07070	COG3177	Filamentation induced by cAMP protein fic
STSP2_RS07085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
STSP2_RS07105	COG4566	intracellular signal transduction
STSP2_RS07130	COG0489	protein tyrosine kinase activity
STSP2_RS07130	COG3206	protein involved in exopolysaccharide biosynthesis
STSP2_RS07135	COG4464	protein tyrosine phosphatase activity
STSP2_RS07150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STSP2_RS07155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
STSP2_RS07170	COG0297	glycogen (starch) synthase activity
STSP2_RS07195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
STSP2_RS07215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
STSP2_RS07250	COG0457	Tetratricopeptide repeat
STSP2_RS07275	COG0352	thiamine-phosphate diphosphorylase activity
STSP2_RS07285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
STSP2_RS07295	COG0134	indole-3-glycerol-phosphate synthase activity
STSP2_RS07300	COG0730	response to heat
STSP2_RS07305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STSP2_RS07310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
STSP2_RS07315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STSP2_RS07320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
STSP2_RS07325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
STSP2_RS07330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
STSP2_RS07360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
STSP2_RS07370	COG1611	Belongs to the LOG family
STSP2_RS07410	COG4284	Utp--glucose-1-phosphate uridylyltransferase
STSP2_RS07415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
STSP2_RS07425	COG0606	chelatase, subunit chli
STSP2_RS07435	COG0469	pyruvate kinase activity
STSP2_RS07440	COG3119	arylsulfatase activity
STSP2_RS07445	COG3335	DDE superfamily endonuclease
STSP2_RS07460	COG0571	ribonuclease III activity
STSP2_RS07485	COG3119	arylsulfatase activity
STSP2_RS07490	COG2084	Dehydrogenase
STSP2_RS07515	COG0321	lipoyl(octanoyl) transferase activity
STSP2_RS07525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
STSP2_RS07525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
STSP2_RS07535	COG0556	nucleotide-excision repair
STSP2_RS07540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
STSP2_RS07545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
STSP2_RS07580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
STSP2_RS07585	COG1191	sigma factor activity
STSP2_RS07620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
STSP2_RS07625	COG1376	ErfK ybiS ycfS ynhG family protein
STSP2_RS07635	COG0811	peptide transport
STSP2_RS07645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
STSP2_RS07670	COG0674	pyruvate-flavodoxin oxidoreductase activity
STSP2_RS07730	COG1032	radical SAM domain protein
STSP2_RS07755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
STSP2_RS07795	COG1067	ATP-dependent peptidase activity
STSP2_RS07805	COG0366	Alpha amylase catalytic
STSP2_RS07815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
STSP2_RS07830	COG1640	4-alpha-glucanotransferase
STSP2_RS07845	COG0714	Associated with various cellular activities
STSP2_RS07855	COG1131	(ABC) transporter
STSP2_RS07890	COG0366	Alpha amylase catalytic
STSP2_RS07890	COG3103	Sh3 type 3 domain protein
STSP2_RS07905	COG2165	general secretion pathway protein
STSP2_RS07945	COG2155	Conserved Protein
STSP2_RS07985	COG3335	DDE superfamily endonuclease
STSP2_RS07995	COG0310	cobalt ion transport
STSP2_RS08000	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
STSP2_RS08005	COG1122	ATPase activity
STSP2_RS08030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STSP2_RS08080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
STSP2_RS08080	COG1648	precorrin-2 dehydrogenase activity
STSP2_RS08085	COG3676	manually curated
STSP2_RS08095	COG3119	arylsulfatase activity
STSP2_RS08115	COG0012	GTP binding
STSP2_RS08120	COG1058	Belongs to the CinA family
STSP2_RS08120	COG1546	Belongs to the CinA family
STSP2_RS08125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS08135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS08140	COG1459	type II secretion system
STSP2_RS08150	COG2165	general secretion pathway protein
STSP2_RS08165	COG4969	Belongs to the N-Me-Phe pilin family
STSP2_RS08190	COG0483	inositol monophosphate 1-phosphatase activity
STSP2_RS08205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
STSP2_RS08215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
STSP2_RS08230	COG0280	phosphate acetyltransferase
STSP2_RS08240	COG2086	electron transfer activity
STSP2_RS08245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STSP2_RS08250	COG1960	acyl-CoA dehydrogenase activity
STSP2_RS08260	COG0358	DNA primase activity
STSP2_RS08265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
STSP2_RS08285	COG2165	general secretion pathway protein
STSP2_RS08290	COG1040	competence protein
STSP2_RS08325	COG0322	excinuclease ABC activity
STSP2_RS08330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STSP2_RS08340	COG0655	NAD(P)H dehydrogenase (quinone) activity
STSP2_RS08360	COG0583	DNA-binding transcription factor activity
STSP2_RS08365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
STSP2_RS08370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
STSP2_RS08375	COG1573	uracil-dna glycosylase
STSP2_RS08390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
STSP2_RS08395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
STSP2_RS08400	COG0805	protein transport
STSP2_RS08405	COG0840	transmembrane signaling receptor activity
STSP2_RS08450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
STSP2_RS08455	COG0512	Glutamine amidotransferase of anthranilate synthase
STSP2_RS08460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
STSP2_RS08465	COG0135	phosphoribosylanthranilate isomerase activity
STSP2_RS08470	COG0133	tryptophan synthase activity
STSP2_RS08475	COG0159	tryptophan synthase activity
STSP2_RS08480	COG0493	'glutamate synthase
STSP2_RS08500	COG0297	glycogen (starch) synthase activity
STSP2_RS08540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
STSP2_RS08555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STSP2_RS08580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
STSP2_RS08585	COG0504	CTP synthase activity
STSP2_RS08590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
STSP2_RS08600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
STSP2_RS08600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STSP2_RS08600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STSP2_RS08610	COG0594	ribonuclease P activity
STSP2_RS08635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
STSP2_RS08640	COG1904	glucuronate isomerase
STSP2_RS08645	COG1472	Belongs to the glycosyl hydrolase 3 family
STSP2_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
STSP2_RS08670	COG0205	6-phosphofructokinase activity
STSP2_RS08680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STSP2_RS08690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STSP2_RS08690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
STSP2_RS08690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
STSP2_RS08700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
STSP2_RS08715	COG1342	Belongs to the UPF0251 family
STSP2_RS08730	COG0489	protein tyrosine kinase activity
STSP2_RS08755	COG1216	Glycosyl transferase, family 2
STSP2_RS08755	COG0463	Glycosyl transferase, family 2
STSP2_RS08760	COG1132	(ABC) transporter
STSP2_RS08770	COG0857	belongs to the CobB CobQ family
STSP2_RS08770	COG0280	phosphate acetyltransferase
STSP2_RS08775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
STSP2_RS08790	COG0616	signal peptide processing
STSP2_RS08830	COG0527	aspartate kinase activity
STSP2_RS08835	COG1525	nuclease
STSP2_RS08865	COG1555	photosystem II stabilization
STSP2_RS08865	COG1596	polysaccharide export
STSP2_RS08885	COG1519	Transferase
STSP2_RS08905	COG2186	Transcriptional regulator
STSP2_RS08930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STSP2_RS08940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STSP2_RS08960	COG5002	protein histidine kinase activity
STSP2_RS08980	COG0072	phenylalanine-tRNA ligase activity
STSP2_RS08990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
STSP2_RS09000	COG0582	viral genome integration into host DNA
STSP2_RS09050	COG2255	four-way junction helicase activity
STSP2_RS09110	COG1518	maintenance of DNA repeat elements
STSP2_RS09165	COG2003	Belongs to the UPF0758 family
STSP2_RS09225	COG0673	inositol 2-dehydrogenase activity
STSP2_RS09230	COG4977	sequence-specific DNA binding
STSP2_RS09260	COG2165	general secretion pathway protein
STSP2_RS09290	COG0383	alpha-mannosidase activity
STSP2_RS09300	COG2814	Major facilitator Superfamily
STSP2_RS09315	COG2165	general secretion pathway protein
STSP2_RS09325	COG1609	Transcriptional regulator
STSP2_RS09330	COG1609	Transcriptional regulator
STSP2_RS09340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
STSP2_RS09365	COG3385	transposase activity
STSP2_RS09385	COG3344	reverse transcriptase
STSP2_RS09390	COG0582	viral genome integration into host DNA
STSP2_RS09470	COG0811	peptide transport
STSP2_RS09475	COG0811	peptide transport
STSP2_RS09480	COG0848	biopolymer transport protein
STSP2_RS09530	COG3344	reverse transcriptase
STSP2_RS09535	COG3328	transposase activity
STSP2_RS09550	COG3250	beta-galactosidase activity
STSP2_RS09580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
STSP2_RS09585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
STSP2_RS09595	COG3119	arylsulfatase activity
STSP2_RS09645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
STSP2_RS09660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
STSP2_RS09665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
STSP2_RS09670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
STSP2_RS09675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STSP2_RS09680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
STSP2_RS09685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
STSP2_RS09690	COG3119	arylsulfatase activity
STSP2_RS09695	COG3119	arylsulfatase activity
STSP2_RS09700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
STSP2_RS09765	COG1131	(ABC) transporter
STSP2_RS09790	COG0166	Belongs to the GPI family
STSP2_RS09805	COG0363	glucosamine-6-phosphate deaminase activity
STSP2_RS09815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
STSP2_RS09820	COG1862	Preprotein translocase
STSP2_RS09825	COG0343	queuine tRNA-ribosyltransferase activity
STSP2_RS09830	COG2385	sporulation resulting in formation of a cellular spore
STSP2_RS09835	COG0202	RNA polymerase activity
STSP2_RS09845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
STSP2_RS09850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
STSP2_RS09865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
STSP2_RS09875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
STSP2_RS09880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
STSP2_RS09890	COG1530	ribonuclease E activity
STSP2_RS09895	COG0517	IMP dehydrogenase activity
STSP2_RS09895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
STSP2_RS09900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
STSP2_RS09915	COG3335	DDE superfamily endonuclease
STSP2_RS09940	COG0165	Argininosuccinate lyase
STSP2_RS09945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
STSP2_RS10020	COG5002	protein histidine kinase activity
STSP2_RS10030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
STSP2_RS10030	COG2199	diguanylate cyclase activity
STSP2_RS10035	COG1366	Belongs to the anti-sigma-factor antagonist family
STSP2_RS10040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS10045	COG1459	type II secretion system
STSP2_RS10050	COG0673	inositol 2-dehydrogenase activity
STSP2_RS10055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
STSP2_RS10060	COG1185	polyribonucleotide nucleotidyltransferase activity
STSP2_RS10065	COG1278	Cold shock
STSP2_RS10070	COG2204	response regulator
STSP2_RS10075	COG0667	Aldo Keto reductase
STSP2_RS10085	COG1063	alcohol dehydrogenase
STSP2_RS10090	COG1217	gtp-binding protein TYPA
STSP2_RS10115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
STSP2_RS10120	COG2814	Major facilitator Superfamily
STSP2_RS10120	COG0477	Major facilitator Superfamily
STSP2_RS10130	COG2165	general secretion pathway protein
STSP2_RS10155	COG1621	beta-fructofuranosidase activity
STSP2_RS10160	COG1621	beta-fructofuranosidase activity
STSP2_RS10165	COG1187	pseudouridine synthase activity
STSP2_RS10175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
STSP2_RS10180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STSP2_RS10185	COG0154	amidase activity
STSP2_RS10190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
STSP2_RS10200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
STSP2_RS10210	COG0515	serine threonine protein kinase
STSP2_RS10215	COG0859	PFAM glycosyl transferase family 9
STSP2_RS10220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
STSP2_RS10225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
STSP2_RS10225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
STSP2_RS10230	COG1663	tetraacyldisaccharide 4'-kinase activity
STSP2_RS10245	COG0612	Peptidase, M16
STSP2_RS10250	COG0612	Peptidase, M16
STSP2_RS10255	COG1196	nuclear chromosome segregation
STSP2_RS10260	COG1706	bacterial-type flagellum-dependent cell motility
STSP2_RS10275	COG0693	protein deglycase activity
STSP2_RS10315	COG0778	Nitroreductase
STSP2_RS10325	COG3345	alpha-galactosidase
STSP2_RS10330	COG1012	belongs to the aldehyde dehydrogenase family
STSP2_RS10330	COG1454	alcohol dehydrogenase
STSP2_RS10335	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
STSP2_RS10340	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
STSP2_RS10365	COG0641	radical SAM
STSP2_RS10370	COG0180	Tryptophanyl-tRNA synthetase
STSP2_RS10380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
STSP2_RS10385	COG3118	belongs to the thioredoxin family
STSP2_RS10390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
STSP2_RS10405	COG1191	sigma factor activity
STSP2_RS10440	COG3852	Histidine kinase
STSP2_RS10445	COG2204	response regulator
STSP2_RS10455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
STSP2_RS10460	COG1940	carbohydrate kinase activity
STSP2_RS10465	COG2086	electron transfer activity
STSP2_RS10470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
STSP2_RS10475	COG0277	FAD linked oxidase domain protein
STSP2_RS10480	COG1063	alcohol dehydrogenase
STSP2_RS10495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
STSP2_RS10500	COG0463	Glycosyl transferase, family 2
STSP2_RS10510	COG0436	Aminotransferase
STSP2_RS10520	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
STSP2_RS10525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
STSP2_RS10530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
STSP2_RS10535	COG0436	Aminotransferase
STSP2_RS10540	COG0745	RESPONSE REGULATOR receiver
STSP2_RS10545	COG0047	phosphoribosylformylglycinamidine synthase activity
STSP2_RS10550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
STSP2_RS10555	COG0287	Prephenate dehydrogenase
STSP2_RS10560	COG0825	malonyl-CoA metabolic process
STSP2_RS10565	COG0698	ribose 5-phosphate isomerase
STSP2_RS10570	COG0009	L-threonylcarbamoyladenylate synthase
STSP2_RS10645	COG0366	Alpha amylase catalytic
STSP2_RS10675	COG0590	tRNA wobble adenosine to inosine editing
STSP2_RS10705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
STSP2_RS10715	COG0617	tRNA 3'-terminal CCA addition
STSP2_RS10730	COG1609	Transcriptional regulator
STSP2_RS10735	COG0477	Major facilitator Superfamily
STSP2_RS10735	COG2814	Major facilitator Superfamily
STSP2_RS10750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
STSP2_RS10755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
STSP2_RS10760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
STSP2_RS10770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
STSP2_RS10790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
STSP2_RS10800	COG0482	sulfurtransferase activity
STSP2_RS10810	COG2912	Transglutaminase-like superfamily
STSP2_RS10815	COG1872	DUF167
STSP2_RS10830	COG0543	2 iron, 2 sulfur cluster binding
STSP2_RS10835	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
STSP2_RS10880	COG2165	general secretion pathway protein
STSP2_RS10900	COG2207	Transcriptional regulator
STSP2_RS10900	COG1609	Transcriptional regulator
STSP2_RS10905	COG0673	inositol 2-dehydrogenase activity
STSP2_RS10935	COG2207	Transcriptional regulator
STSP2_RS10935	COG1609	Transcriptional regulator
STSP2_RS10945	COG3335	DDE superfamily endonuclease
STSP2_RS10975	COG3335	DDE superfamily endonuclease
STSP2_RS10980	COG3119	arylsulfatase activity
STSP2_RS11035	COG3250	beta-galactosidase activity
STSP2_RS11045	COG3250	beta-galactosidase activity
STSP2_RS11050	COG3507	Belongs to the glycosyl hydrolase 43 family
STSP2_RS11090	COG3940	Belongs to the glycosyl hydrolase 43 family
STSP2_RS11100	COG3335	DDE superfamily endonuclease
STSP2_RS11140	COG2211	Major facilitator Superfamily
STSP2_RS11145	COG2165	general secretion pathway protein
STSP2_RS11170	COG1609	Transcriptional regulator
STSP2_RS11170	COG2207	Transcriptional regulator
STSP2_RS11175	COG1070	Carbohydrate kinase
STSP2_RS11180	COG0477	Major facilitator Superfamily
STSP2_RS11180	COG2814	Major facilitator Superfamily
STSP2_RS11195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
STSP2_RS11200	COG4536	flavin adenine dinucleotide binding
STSP2_RS11205	COG1253	flavin adenine dinucleotide binding
STSP2_RS11245	COG4864	UPF0365 protein
STSP2_RS11255	COG1030	water channel activity
STSP2_RS11260	COG0436	Aminotransferase
STSP2_RS11275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
STSP2_RS11280	COG0416	fatty acid biosynthetic process
STSP2_RS11285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
STSP2_RS11290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
STSP2_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
STSP2_RS11300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
STSP2_RS11305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
STSP2_RS11330	COG0784	Response regulator, receiver
STSP2_RS11330	COG4191	Histidine kinase
STSP2_RS11430	COG2207	Transcriptional regulator
STSP2_RS11435	COG1472	Belongs to the glycosyl hydrolase 3 family
STSP2_RS11475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
STSP2_RS11515	COG4974	Belongs to the 'phage' integrase family
STSP2_RS11555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
STSP2_RS11570	COG2165	general secretion pathway protein
STSP2_RS11590	COG1606	tRNA processing
STSP2_RS11605	COG0205	6-phosphofructokinase activity
STSP2_RS11620	COG1940	carbohydrate kinase activity
STSP2_RS11625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
STSP2_RS11635	COG4974	Belongs to the 'phage' integrase family
STSP2_RS11665	COG0438	transferase activity, transferring glycosyl groups
STSP2_RS11675	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
STSP2_RS11680	COG4251	negative regulation of phosphorylation
STSP2_RS11700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STSP2_RS11705	COG0004	ammonium transporteR
STSP2_RS11710	COG0347	Belongs to the P(II) protein family
STSP2_RS11720	COG0067	glutamate synthase
STSP2_RS11720	COG0070	glutamate synthase
STSP2_RS11720	COG0069	glutamate synthase activity
STSP2_RS11735	COG1028	Short-chain dehydrogenase reductase Sdr
STSP2_RS11740	COG1063	alcohol dehydrogenase
STSP2_RS11750	COG1070	Carbohydrate kinase
STSP2_RS11755	COG0508	dehydrogenase complex catalyzes the overall conversion of
STSP2_RS11760	COG0022	dehydrogenase e1 component
STSP2_RS11760	COG0508	dehydrogenase complex catalyzes the overall conversion of
STSP2_RS11765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STSP2_RS11820	COG4154	Belongs to the RbsD FucU family
STSP2_RS11830	COG0463	Glycosyl transferase, family 2
STSP2_RS11865	COG0673	inositol 2-dehydrogenase activity
STSP2_RS11900	COG0673	inositol 2-dehydrogenase activity
STSP2_RS11910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
STSP2_RS11935	COG1408	metallophosphoesterase
STSP2_RS11945	COG1716	ATPase activity
STSP2_RS11950	COG3335	DDE superfamily endonuclease
STSP2_RS11960	COG0564	pseudouridine synthase activity
STSP2_RS11980	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
STSP2_RS12000	COG2165	general secretion pathway protein
STSP2_RS12045	COG1959	2 iron, 2 sulfur cluster binding
STSP2_RS12055	COG3676	manually curated
STSP2_RS12065	COG0004	ammonium transporteR
STSP2_RS12105	COG0733	neurotransmitter:sodium symporter activity
STSP2_RS12120	COG1704	LemA family
STSP2_RS12135	COG0501	Belongs to the peptidase M48B family
STSP2_RS12145	COG2239	Acts as a magnesium transporter
STSP2_RS12155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS12170	COG3250	beta-galactosidase activity
STSP2_RS12185	COG0515	serine threonine protein kinase
STSP2_RS12185	COG2815	serine threonine protein kinase
STSP2_RS12190	COG1309	transcriptional regulator
STSP2_RS12195	COG0505	Belongs to the CarA family
STSP2_RS12205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
STSP2_RS12205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
STSP2_RS12210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
STSP2_RS12250	COG1482	cell wall glycoprotein biosynthetic process
STSP2_RS12265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
STSP2_RS12270	COG3250	beta-galactosidase activity
STSP2_RS12290	COG1918	ferrous iron import across plasma membrane
STSP2_RS12290	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
STSP2_RS12305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
STSP2_RS12320	COG4608	Belongs to the ABC transporter superfamily
STSP2_RS12325	COG0444	Belongs to the ABC transporter superfamily
STSP2_RS12330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
STSP2_RS12335	COG0601	transmembrane transport
STSP2_RS12340	COG4166	transmembrane transport
STSP2_RS12345	COG0747	negative chemotaxis
STSP2_RS12370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
STSP2_RS12375	COG0138	bifunctional purine biosynthesis protein purh
STSP2_RS12395	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
STSP2_RS12400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
STSP2_RS12405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
STSP2_RS12410	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STSP2_RS12415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
STSP2_RS12420	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
STSP2_RS12425	COG0356	it plays a direct role in the translocation of protons across the membrane
STSP2_RS12445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
STSP2_RS12465	COG1595	DNA-templated transcription, initiation
STSP2_RS12475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
STSP2_RS12480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
STSP2_RS12495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
STSP2_RS12515	COG2183	response to ionizing radiation
STSP2_RS12520	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
STSP2_RS12535	COG0776	regulation of translation
STSP2_RS12540	COG1278	Cold shock
STSP2_RS12550	COG0493	'glutamate synthase
STSP2_RS12550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
STSP2_RS12555	COG0543	2 iron, 2 sulfur cluster binding
STSP2_RS12560	COG0577	efflux transmembrane transporter activity
STSP2_RS12560	COG1136	(ABC) transporter
STSP2_RS12565	COG1136	(ABC) transporter
STSP2_RS12570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
STSP2_RS12590	COG3119	arylsulfatase activity
STSP2_RS12595	COG3345	alpha-galactosidase
STSP2_RS12605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
STSP2_RS12610	COG1091	dTDP-4-dehydrorhamnose reductase activity
STSP2_RS12615	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
STSP2_RS12620	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
STSP2_RS12625	COG4585	Histidine kinase
STSP2_RS12635	COG2197	response regulator
STSP2_RS12645	COG0784	Response regulator, receiver
STSP2_RS12655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
STSP2_RS12660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
STSP2_RS12675	COG0500	methyltransferase
STSP2_RS12700	COG1215	transferase activity, transferring glycosyl groups
STSP2_RS12730	COG1216	Glycosyl transferase, family 2
STSP2_RS12735	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
STSP2_RS12750	COG0673	inositol 2-dehydrogenase activity
STSP2_RS12775	COG0489	protein tyrosine kinase activity
STSP2_RS12780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
STSP2_RS12790	COG2197	response regulator
STSP2_RS12845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
STSP2_RS12880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
STSP2_RS12890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
STSP2_RS12895	COG1331	Highly conserved protein containing a thioredoxin domain
STSP2_RS12910	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
STSP2_RS12915	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
STSP2_RS12920	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
STSP2_RS12925	COG1805	sodium ion transport
STSP2_RS12930	COG1773	rubredoxin
STSP2_RS12945	COG2033	superoxide reductase activity
STSP2_RS12950	COG0426	domain, Protein
STSP2_RS12955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
STSP2_RS12960	COG1592	Rubrerythrin
STSP2_RS12985	COG0848	biopolymer transport protein
STSP2_RS12995	COG0811	peptide transport
STSP2_RS13010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
STSP2_RS13020	COG0488	(ABC) transporter
STSP2_RS13050	COG0673	inositol 2-dehydrogenase activity
STSP2_RS13055	COG2207	Transcriptional regulator
STSP2_RS13060	COG3250	beta-galactosidase activity
STSP2_RS13065	COG0366	Alpha amylase catalytic
STSP2_RS13070	COG0745	RESPONSE REGULATOR receiver
STSP2_RS13075	COG5002	protein histidine kinase activity
STSP2_RS13085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
STSP2_RS13090	COG0573	inorganic phosphate transmembrane transporter activity
STSP2_RS13095	COG0581	inorganic phosphate transmembrane transporter activity
STSP2_RS13100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
STSP2_RS13110	COG0704	Plays a role in the regulation of phosphate uptake
STSP2_RS13135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
STSP2_RS13150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
STSP2_RS13175	COG5002	protein histidine kinase activity
STSP2_RS13190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
STSP2_RS13235	COG0515	serine threonine protein kinase
STSP2_RS13240	COG0778	Nitroreductase
STSP2_RS13240	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
STSP2_RS13250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
STSP2_RS13270	COG0438	transferase activity, transferring glycosyl groups
STSP2_RS13290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
STSP2_RS13295	COG3481	metal-dependent phosphohydrolase, HD sub domain
STSP2_RS13320	COG1459	type II secretion system
STSP2_RS13330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS13355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
STSP2_RS13360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
STSP2_RS13370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS13420	COG1192	Involved in chromosome partitioning
STSP2_RS13445	COG2873	o-acetylhomoserine
STSP2_RS13455	COG1045	serine acetyltransferase
STSP2_RS13465	COG1959	2 iron, 2 sulfur cluster binding
STSP2_RS13525	COG0438	transferase activity, transferring glycosyl groups
STSP2_RS13535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
STSP2_RS13550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
STSP2_RS13560	COG0508	dehydrogenase complex catalyzes the overall conversion of
STSP2_RS13575	COG1368	sulfuric ester hydrolase activity
STSP2_RS13580	COG2207	Transcriptional regulator
STSP2_RS13585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
STSP2_RS13590	COG0750	zinc metalloprotease
STSP2_RS13590	COG0750	zinc metalloprotease
STSP2_RS13595	COG1216	Glycosyl transferase, family 2
STSP2_RS13600	COG1216	Glycosyl transferase, family 2
STSP2_RS13605	COG1216	Glycosyl transferase, family 2
STSP2_RS13630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
STSP2_RS13640	COG0463	Glycosyl transferase, family 2
STSP2_RS13665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS13670	COG1459	type II secretion system
STSP2_RS13715	COG2088	sporulation resulting in formation of a cellular spore
STSP2_RS13720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
STSP2_RS13740	COG0424	maF-like protein
STSP2_RS13750	COG1595	DNA-templated transcription, initiation
STSP2_RS13760	COG0668	transmembrane transport
STSP2_RS13765	COG1363	Peptidase, m42
STSP2_RS13775	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
STSP2_RS13800	COG2866	Carboxypeptidase
STSP2_RS13805	COG0842	Transport permease protein
STSP2_RS13810	COG1131	(ABC) transporter
STSP2_RS13820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
STSP2_RS13825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
STSP2_RS13835	COG0602	queuosine metabolic process
STSP2_RS13850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
STSP2_RS13855	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
STSP2_RS13870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
STSP2_RS13875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
STSP2_RS13885	COG0428	transporter
STSP2_RS13900	COG3119	arylsulfatase activity
STSP2_RS13910	COG3335	DDE superfamily endonuclease
STSP2_RS13925	COG0758	DNA mediated transformation
STSP2_RS13925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
STSP2_RS13940	COG3676	manually curated
STSP2_RS13955	COG4251	negative regulation of phosphorylation
STSP2_RS13960	COG4251	negative regulation of phosphorylation
STSP2_RS13965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
STSP2_RS13965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
STSP2_RS13965	COG0674	pyruvate-flavodoxin oxidoreductase activity
STSP2_RS13965	COG1013	pyruvate-flavodoxin oxidoreductase activity
STSP2_RS13995	COG3206	protein involved in exopolysaccharide biosynthesis
STSP2_RS13995	COG0489	protein tyrosine kinase activity
STSP2_RS14005	COG0708	Exodeoxyribonuclease III
STSP2_RS14010	COG1131	(ABC) transporter
STSP2_RS14030	COG1132	(ABC) transporter
STSP2_RS14040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
STSP2_RS14045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
STSP2_RS14050	COG1136	(ABC) transporter
STSP2_RS14055	COG0577	efflux transmembrane transporter activity
STSP2_RS14070	COG0237	dephospho-CoA kinase activity
STSP2_RS14075	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
STSP2_RS14080	COG0525	valine-tRNA ligase activity
STSP2_RS14090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
STSP2_RS14105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
STSP2_RS14120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
STSP2_RS14125	COG1120	ATPase activity
STSP2_RS14130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
STSP2_RS14135	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
STSP2_RS14150	COG2226	methyltransferase
STSP2_RS14155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
STSP2_RS14160	COG1692	metallophosphoesterase
STSP2_RS14165	COG1418	mRNA catabolic process
STSP2_RS14195	COG1570	exodeoxyribonuclease VII activity
STSP2_RS14200	COG1722	exodeoxyribonuclease VII activity
STSP2_RS14230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
STSP2_RS14230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
STSP2_RS14265	COG1028	Short-chain dehydrogenase reductase Sdr
STSP2_RS14270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
STSP2_RS14275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
STSP2_RS14285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
STSP2_RS14330	COG4796	Type ii and iii secretion system protein
STSP2_RS14365	COG1459	type II secretion system
STSP2_RS14370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
STSP2_RS14375	COG4191	Histidine kinase
STSP2_RS14395	COG4968	Prepilin-type N-terminal cleavage methylation domain
STSP2_RS14400	COG1595	DNA-templated transcription, initiation
STSP2_RS14450	COG0673	inositol 2-dehydrogenase activity
STSP2_RS14465	COG0673	inositol 2-dehydrogenase activity
STSP2_RS14470	COG1940	carbohydrate kinase activity
STSP2_RS14490	COG3119	arylsulfatase activity
STSP2_RS14495	COG2165	general secretion pathway protein
STSP2_RS14500	COG3119	arylsulfatase activity
STSP2_RS14520	COG0383	alpha-mannosidase activity
STSP2_RS14570	COG3119	arylsulfatase activity
STSP2_RS14575	COG3119	arylsulfatase activity
STSP2_RS14585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
STSP2_RS14610	COG0537	adenosine 5'-monophosphoramidase activity
STSP2_RS14615	COG0203	ribosomal protein L17
STSP2_RS14620	COG0202	RNA polymerase activity
STSP2_RS14625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
STSP2_RS14630	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
STSP2_RS14645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
STSP2_RS14650	COG0024	Methionine aminopeptidase
STSP2_RS14655	COG0563	adenylate kinase activity
STSP2_RS14660	COG0201	protein transport
STSP2_RS14665	COG0200	Binds to the 23S rRNA
STSP2_RS14670	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
STSP2_RS14675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
STSP2_RS14685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
STSP2_RS14690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
STSP2_RS14695	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
STSP2_RS14700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
STSP2_RS14705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
STSP2_RS14710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
STSP2_RS14715	COG0255	Belongs to the universal ribosomal protein uL29 family
STSP2_RS14720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
STSP2_RS14725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
STSP2_RS14730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
STSP2_RS14735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
STSP2_RS14740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
STSP2_RS14745	COG0089	rRNA binding
STSP2_RS14750	COG0088	Forms part of the polypeptide exit tunnel
STSP2_RS14755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
STSP2_RS14760	COG0051	transcription antitermination factor activity, RNA binding
STSP2_RS14765	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
STSP2_RS14770	COG0049	tRNA binding
STSP2_RS14775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
STSP2_RS14780	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
STSP2_RS14785	COG0085	RNA polymerase activity
STSP2_RS14790	COG0222	ribosome binding
STSP2_RS14795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
STSP2_RS14800	COG0081	regulation of translation
STSP2_RS14805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
STSP2_RS14830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
STSP2_RS14855	COG0336	Belongs to the RNA methyltransferase TrmD family
STSP2_RS14875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
STSP2_RS14900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
STSP2_RS14905	COG0335	large ribosomal subunit rRNA binding
STSP2_RS14910	COG0792	nuclease activity
STSP2_RS14915	COG0084	hydrolase, TatD family'
STSP2_RS14920	COG2890	protein-(glutamine-N5) methyltransferase activity
STSP2_RS14925	COG0017	Asparaginyl-tRNA synthetase
STSP2_RS14930	COG2731	YhcH YjgK YiaL family protein
STSP2_RS14940	COG0423	glycine-tRNA ligase activity
STSP2_RS14955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
STSP2_RS14960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
STSP2_RS14970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
STSP2_RS14975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
STSP2_RS15015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
STSP2_RS15025	COG1956	GAF domain-containing protein
STSP2_RS15030	COG4251	negative regulation of phosphorylation
STSP2_RS15035	COG4251	negative regulation of phosphorylation
STSP2_RS15045	COG0442	prolyl-tRNA aminoacylation
STSP2_RS15055	COG4251	negative regulation of phosphorylation
STSP2_RS15070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
STSP2_RS15075	COG0436	Aminotransferase
STSP2_RS15110	COG3119	arylsulfatase activity
STSP2_RS15200	COG1674	ftsk spoiiie
STSP2_RS15200	COG4980	gas vesicle protein
STSP2_RS15410	COG1830	Aldolase
STSP2_RS15430	COG1028	Short-chain dehydrogenase reductase Sdr
STSP2_RS15435	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
STSP2_RS15445	COG1414	Transcriptional regulator
STSP2_RS15450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
STSP2_RS15465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
STSP2_RS15475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
STSP2_RS15520	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
STSP2_RS15530	COG4956	integral membrane protein (PIN domain superfamily)
STSP2_RS15535	COG0668	transmembrane transport
STSP2_RS15570	COG3584	3D domain protein
STSP2_RS15585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
STSP2_RS15630	COG1609	Transcriptional regulator
STSP2_RS15630	COG2207	Transcriptional regulator
STSP2_RS15665	COG1595	DNA-templated transcription, initiation
STSP2_RS15680	COG2815	serine threonine protein kinase
STSP2_RS15680	COG0515	serine threonine protein kinase
STSP2_RS15710	COG2255	four-way junction helicase activity
STSP2_RS15720	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
STSP2_RS15770	COG2176	DNA-directed DNA polymerase activity
STSP2_RS15835	COG1061	Type III restriction enzyme res subunit
STSP2_RS15880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
STSP2_RS15945	COG1136	(ABC) transporter
STSP2_RS15960	COG0784	Response regulator, receiver
STSP2_RS15960	COG2205	protein histidine kinase activity
STSP2_RS15960	COG2198	Histidine kinase
STSP2_RS15965	COG5002	protein histidine kinase activity
STSP2_RS15975	COG1881	PFAM PEBP family protein
STSP2_RS15985	COG0544	peptidyl-prolyl cis-trans isomerase activity
STSP2_RS15990	COG0740	serine-type endopeptidase activity
STSP2_RS15995	COG0740	serine-type endopeptidase activity
STSP2_RS16010	COG0815	Transfers the fatty acyl group on membrane lipoproteins
STSP2_RS16040	COG0768	penicillin binding
STSP2_RS16045	COG0768	penicillin binding
STSP2_RS16060	COG0275	rRNA processing
STSP2_RS16070	COG2001	Belongs to the MraZ family
STSP2_RS16085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
STSP2_RS16090	COG2217	Heavy metal translocating P-type atpase
STSP2_RS16115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
STSP2_RS16120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
STSP2_RS16125	COG1796	DNA polymerase
STSP2_RS16125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
STSP2_RS16130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
STSP2_RS16150	COG0438	transferase activity, transferring glycosyl groups
STSP2_RS16160	COG0693	protein deglycase activity
STSP2_RS16180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
STSP2_RS16205	COG2897	thiosulfate sulfurtransferase activity
STSP2_RS16225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STSP2_RS16230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
STSP2_RS16235	COG0509	glycine decarboxylation via glycine cleavage system
STSP2_RS16240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
STSP2_RS16250	COG0443	Heat shock 70 kDa protein
STSP2_RS16260	COG0275	rRNA processing
STSP2_RS16275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
STSP2_RS16280	COG1691	(AIR) carboxylase
STSP2_RS16285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
STSP2_RS16285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
STSP2_RS16355	COG0233	cytoplasmic translational termination
STSP2_RS16360	COG0528	UMP kinase activity
STSP2_RS16365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
STSP2_RS16370	COG0052	Belongs to the universal ribosomal protein uS2 family
STSP2_RS16380	COG1595	DNA-templated transcription, initiation
STSP2_RS16390	COG1595	DNA-templated transcription, initiation
STSP2_RS16395	COG0668	transmembrane transport
STSP2_RS16400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
STSP2_RS16430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
STSP2_RS16440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
STSP2_RS16445	COG3046	protein related to deoxyribodipyrimidine photolyase
STSP2_RS16460	COG0826	peptidase U32
STSP2_RS16465	COG0778	Nitroreductase
STSP2_RS16475	COG1181	Belongs to the D-alanine--D-alanine ligase family
STSP2_RS16480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
STSP2_RS16485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
STSP2_RS16490	COG0357	Ribosomal RNA small subunit methyltransferase G
STSP2_RS16500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
STSP2_RS16505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
STSP2_RS16510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
STSP2_RS16515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
STSP2_RS16530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
STSP2_RS16540	COG3335	DDE superfamily endonuclease
STSP2_RS16560	COG0519	Catalyzes the synthesis of GMP from XMP
STSP2_RS16560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
STSP2_RS16565	COG0517	IMP dehydrogenase activity
STSP2_RS16565	COG0516	GMP reductase activity
STSP2_RS16570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
STSP2_RS16580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
STSP2_RS16610	COG0673	inositol 2-dehydrogenase activity
STSP2_RS16615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
STSP2_RS16630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
STSP2_RS16635	COG1993	acr, cog1993
STSP2_RS16640	COG0612	Peptidase, M16
STSP2_RS16650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
STSP2_RS16655	COG0540	Belongs to the ATCase OTCase family
STSP2_RS16660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
STSP2_RS16680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
STSP2_RS16690	COG1214	PFAM Peptidase M22, glycoprotease
STSP2_RS16695	COG0459	protein refolding
STSP2_RS16700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
STSP2_RS16705	COG0459	protein refolding
STSP2_RS16710	COG0484	heat shock protein binding
STSP2_RS16715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
STSP2_RS16730	COG0285	dihydrofolate synthase activity
STSP2_RS16760	COG1136	(ABC) transporter
STSP2_RS16765	COG0577	efflux transmembrane transporter activity
STSP2_RS16765	COG1136	(ABC) transporter
STSP2_RS16770	COG0142	geranyltranstransferase activity
STSP2_RS16780	COG1136	(ABC) transporter
STSP2_RS16795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
STSP2_RS16800	COG0793	Belongs to the peptidase S41A family
STSP2_RS16805	COG0191	fructose-bisphosphate aldolase activity
STSP2_RS16830	COG1971	Probably functions as a manganese efflux pump
STSP2_RS16835	COG3387	PFAM Glycoside hydrolase 15-related
STSP2_RS16845	COG4968	Prepilin-type N-terminal cleavage methylation domain
STSP2_RS16850	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
STSP2_RS16885	COG0045	succinate-CoA ligase (ADP-forming) activity
STSP2_RS16890	COG1725	Transcriptional regulator
STSP2_RS16900	COG2165	general secretion pathway protein
STSP2_RS16955	COG3676	manually curated
STSP2_RS16960	COG0084	hydrolase, TatD family'
STSP2_RS16965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
STSP2_RS16980	COG3039	Transposase
STSP2_RS16990	COG0840	transmembrane signaling receptor activity
STSP2_RS17010	COG0667	Aldo Keto reductase
STSP2_RS17015	COG1414	Transcriptional regulator
STSP2_RS17025	COG2314	TM2 domain
STSP2_RS17030	COG0330	HflC and HflK could
STSP2_RS17050	COG4585	Histidine kinase
STSP2_RS17065	COG1477	protein flavinylation
STSP2_RS17070	COG3119	arylsulfatase activity
STSP2_RS17075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
STSP2_RS17085	COG1509	lysine 2,3-aminomutase activity
STSP2_RS17090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
STSP2_RS17095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
STSP2_RS17100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
STSP2_RS17125	COG0438	transferase activity, transferring glycosyl groups
STSP2_RS17175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
STSP2_RS17190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
STSP2_RS17210	COG1137	ATPase activity
STSP2_RS17215	COG0242	peptide deformylase activity
STSP2_RS17220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
STSP2_RS17225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
STSP2_RS17225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA