locus-tag	class	description
G4Y79_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G4Y79_RS00025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4Y79_RS00045	COG1196	nuclear chromosome segregation
G4Y79_RS00045	COG0739	heme binding
G4Y79_RS00045	COG0741	lytic transglycosylase activity
G4Y79_RS00060	COG1404	Belongs to the peptidase S8 family
G4Y79_RS00115	COG0419	ATPase involved in DNA repair
G4Y79_RS00120	COG2124	cytochrome p450
G4Y79_RS00130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4Y79_RS00150	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G4Y79_RS00175	COG0174	glutamine synthetase
G4Y79_RS00215	COG1674	ftsk spoiiie
G4Y79_RS00230	COG5002	protein histidine kinase activity
G4Y79_RS00235	COG1803	Methylglyoxal synthase
G4Y79_RS00235	COG1597	lipid kinase activity
G4Y79_RS00280	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G4Y79_RS00305	COG0823	Involved in the tonB-independent uptake of proteins
G4Y79_RS00305	COG1506	peptidase
G4Y79_RS00305	COG4946	Tricorn protease homolog
G4Y79_RS00310	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G4Y79_RS00310	COG1672	PFAM Archaeal ATPase
G4Y79_RS00355	COG0081	regulation of translation
G4Y79_RS00360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G4Y79_RS00365	COG0250	Participates in transcription elongation, termination and antitermination
G4Y79_RS00380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4Y79_RS00405	COG0412	Dienelactone hydrolase
G4Y79_RS00415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4Y79_RS00450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4Y79_RS00460	COG2226	methyltransferase
G4Y79_RS00470	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS00485	COG1595	DNA-templated transcription, initiation
G4Y79_RS00495	COG2124	cytochrome p450
G4Y79_RS00575	COG1234	tRNA 3'-trailer cleavage
G4Y79_RS00585	COG2815	serine threonine protein kinase
G4Y79_RS00585	COG0515	serine threonine protein kinase
G4Y79_RS00610	COG0420	3'-5' exonuclease activity
G4Y79_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS00685	COG3347	Dehydrogenase
G4Y79_RS00700	COG1070	Carbohydrate kinase
G4Y79_RS00705	COG0463	Glycosyl transferase, family 2
G4Y79_RS00705	COG1216	Glycosyl transferase, family 2
G4Y79_RS00710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G4Y79_RS00715	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4Y79_RS00735	COG0583	DNA-binding transcription factor activity
G4Y79_RS00775	COG0295	cytidine deaminase activity
G4Y79_RS00785	COG5504	Zn-dependent protease
G4Y79_RS00790	COG2169	Transcriptional regulator
G4Y79_RS00790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4Y79_RS00800	COG2815	serine threonine protein kinase
G4Y79_RS00800	COG0515	serine threonine protein kinase
G4Y79_RS00825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G4Y79_RS00835	COG0456	acetyltransferase
G4Y79_RS00870	COG2234	aminopeptidase activity
G4Y79_RS00875	COG1069	ribulokinase activity
G4Y79_RS00880	COG0235	Class ii aldolase
G4Y79_RS00885	COG2160	L-arabinose isomerase activity
G4Y79_RS00890	COG1063	alcohol dehydrogenase
G4Y79_RS00900	COG2205	protein histidine kinase activity
G4Y79_RS00915	COG0471	metal ion transport
G4Y79_RS00915	COG0490	domain, Protein
G4Y79_RS00920	COG0631	protein serine/threonine phosphatase activity
G4Y79_RS00930	COG0456	acetyltransferase
G4Y79_RS00940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4Y79_RS00945	COG0477	Major facilitator Superfamily
G4Y79_RS00960	COG4956	integral membrane protein (PIN domain superfamily)
G4Y79_RS00970	COG4251	negative regulation of phosphorylation
G4Y79_RS01010	COG0475	glutathione-regulated potassium exporter activity
G4Y79_RS01025	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS01045	COG2217	Heavy metal translocating P-type atpase
G4Y79_RS01130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4Y79_RS01135	COG0514	ATP-dependent DNA helicase (RecQ)
G4Y79_RS01175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Y79_RS01205	COG2442	InterPro IPR007367
G4Y79_RS01225	COG3186	Phenylalanine-4-hydroxylase
G4Y79_RS01235	COG1192	Involved in chromosome partitioning
G4Y79_RS01250	COG0358	DNA primase activity
G4Y79_RS01265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4Y79_RS01270	COG2201	protein-glutamate methylesterase activity
G4Y79_RS01305	COG3118	belongs to the thioredoxin family
G4Y79_RS01330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Y79_RS01375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Y79_RS01425	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4Y79_RS01430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4Y79_RS01445	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4Y79_RS01470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4Y79_RS01520	COG0328	RNA-DNA hybrid ribonuclease activity
G4Y79_RS01525	COG3118	belongs to the thioredoxin family
G4Y79_RS01545	COG1742	UPF0060 membrane protein
G4Y79_RS01570	COG2264	protein methyltransferase activity
G4Y79_RS01625	COG2072	flavoprotein involved in K transport
G4Y79_RS01630	COG0640	Transcriptional regulator
G4Y79_RS01655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4Y79_RS01655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4Y79_RS01665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Y79_RS01685	COG0785	Cytochrome C biogenesis protein
G4Y79_RS01700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Y79_RS01715	COG0501	Belongs to the peptidase M48B family
G4Y79_RS01735	COG1136	(ABC) transporter
G4Y79_RS01740	COG0577	efflux transmembrane transporter activity
G4Y79_RS01775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4Y79_RS01845	COG5433	transposase activity
G4Y79_RS01855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4Y79_RS01895	COG2217	Heavy metal translocating P-type atpase
G4Y79_RS01900	COG2197	response regulator
G4Y79_RS01925	COG2197	response regulator
G4Y79_RS01940	COG5002	protein histidine kinase activity
G4Y79_RS01945	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS01955	COG2217	Heavy metal translocating P-type atpase
G4Y79_RS01960	COG2217	Heavy metal translocating P-type atpase
G4Y79_RS01985	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4Y79_RS02005	COG1192	Involved in chromosome partitioning
G4Y79_RS02010	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS02030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Y79_RS02085	COG0714	Associated with various cellular activities
G4Y79_RS02150	COG1215	transferase activity, transferring glycosyl groups
G4Y79_RS02175	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4Y79_RS02180	COG2890	protein-(glutamine-N5) methyltransferase activity
G4Y79_RS02185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Y79_RS02210	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS02215	COG0670	Belongs to the BI1 family
G4Y79_RS02220	COG0824	Thioesterase
G4Y79_RS02225	COG0285	dihydrofolate synthase activity
G4Y79_RS02230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4Y79_RS02235	COG2815	serine threonine protein kinase
G4Y79_RS02235	COG0515	serine threonine protein kinase
G4Y79_RS02240	COG0622	Phosphoesterase
G4Y79_RS02245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4Y79_RS02260	COG0494	nUDIX hydrolase
G4Y79_RS02280	COG2226	methyltransferase
G4Y79_RS02285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Y79_RS02290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Y79_RS02290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS02295	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G4Y79_RS02310	COG0336	Belongs to the RNA methyltransferase TrmD family
G4Y79_RS02320	COG1716	ATPase activity
G4Y79_RS02325	COG2271	Major facilitator Superfamily
G4Y79_RS02335	COG0492	ferredoxin-NADP+ reductase activity
G4Y79_RS02345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Y79_RS02350	COG0784	Response regulator, receiver
G4Y79_RS02360	COG2204	response regulator
G4Y79_RS02365	COG2204	response regulator
G4Y79_RS02375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Y79_RS02400	COG1316	TRANSCRIPTIONal
G4Y79_RS02405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4Y79_RS02430	COG1215	transferase activity, transferring glycosyl groups
G4Y79_RS02445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G4Y79_RS02445	COG0646	methionine synthase
G4Y79_RS02470	COG2226	methyltransferase
G4Y79_RS02510	COG1802	Transcriptional regulator
G4Y79_RS02515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Y79_RS02525	COG0436	Aminotransferase
G4Y79_RS02535	COG1363	Peptidase, m42
G4Y79_RS02540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS02550	COG0747	negative chemotaxis
G4Y79_RS02575	COG2382	esterase
G4Y79_RS02580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4Y79_RS02590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4Y79_RS02595	COG0490	domain, Protein
G4Y79_RS02595	COG0471	metal ion transport
G4Y79_RS02610	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS02640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4Y79_RS02650	COG0151	Belongs to the GarS family
G4Y79_RS02655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G4Y79_RS02660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G4Y79_RS02670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4Y79_RS02675	COG0667	Aldo Keto reductase
G4Y79_RS02680	COG0667	Aldo Keto reductase
G4Y79_RS02685	COG0789	Transcriptional regulator
G4Y79_RS02685	COG4978	Transcriptional regulator
G4Y79_RS02725	COG0697	spore germination
G4Y79_RS02785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Y79_RS02790	COG1501	Belongs to the glycosyl hydrolase 31 family
G4Y79_RS02795	COG1501	Belongs to the glycosyl hydrolase 31 family
G4Y79_RS02805	COG1175	transmembrane transport
G4Y79_RS02825	COG2124	cytochrome p450
G4Y79_RS02845	COG4585	Histidine kinase
G4Y79_RS02850	COG0477	Major facilitator Superfamily
G4Y79_RS02865	COG4166	transmembrane transport
G4Y79_RS02875	COG2365	Tyrosine phosphatase family
G4Y79_RS02885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS02905	COG1233	COG1233 Phytoene dehydrogenase and related
G4Y79_RS02915	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS02920	COG1175	transmembrane transport
G4Y79_RS02935	COG1609	Transcriptional regulator
G4Y79_RS02940	COG1486	melibiose metabolic process
G4Y79_RS02945	COG3940	Belongs to the glycosyl hydrolase 43 family
G4Y79_RS02955	COG1609	Transcriptional regulator
G4Y79_RS02965	COG1175	transmembrane transport
G4Y79_RS02990	COG0457	Tetratricopeptide repeat
G4Y79_RS03000	COG4608	Belongs to the ABC transporter superfamily
G4Y79_RS03005	COG0444	Belongs to the ABC transporter superfamily
G4Y79_RS03010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS03020	COG0747	negative chemotaxis
G4Y79_RS03050	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS03055	COG0531	amino acid
G4Y79_RS03065	COG2205	protein histidine kinase activity
G4Y79_RS03070	COG2342	PFAM TM1410 hypothetical-related protein
G4Y79_RS03075	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS03080	COG1175	transmembrane transport
G4Y79_RS03090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Y79_RS03095	COG1486	melibiose metabolic process
G4Y79_RS03100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Y79_RS03105	COG3684	Belongs to the aldolase LacD family
G4Y79_RS03110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Y79_RS03120	COG1105	Belongs to the carbohydrate kinase PfkB family
G4Y79_RS03140	COG3250	beta-galactosidase activity
G4Y79_RS03150	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS03160	COG1609	Transcriptional regulator
G4Y79_RS03175	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G4Y79_RS03180	COG0154	amidase activity
G4Y79_RS03190	COG0515	serine threonine protein kinase
G4Y79_RS03190	COG2815	serine threonine protein kinase
G4Y79_RS03270	COG0154	amidase activity
G4Y79_RS03280	COG0789	Transcriptional regulator
G4Y79_RS03285	COG0667	Aldo Keto reductase
G4Y79_RS03295	COG0330	HflC and HflK could
G4Y79_RS03305	COG0528	UMP kinase activity
G4Y79_RS03310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G4Y79_RS03315	COG0052	Belongs to the universal ribosomal protein uS2 family
G4Y79_RS03320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4Y79_RS03330	COG0251	oxidation-reduction process
G4Y79_RS03360	COG2378	regulation of single-species biofilm formation
G4Y79_RS03380	COG0667	Aldo Keto reductase
G4Y79_RS03390	COG1501	Belongs to the glycosyl hydrolase 31 family
G4Y79_RS03395	COG4608	Belongs to the ABC transporter superfamily
G4Y79_RS03400	COG0444	Belongs to the ABC transporter superfamily
G4Y79_RS03405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS03410	COG0601	transmembrane transport
G4Y79_RS03415	COG0747	negative chemotaxis
G4Y79_RS03420	COG1609	Transcriptional regulator
G4Y79_RS03430	COG3338	carbonate dehydratase activity
G4Y79_RS03470	COG1335	isochorismatase
G4Y79_RS03480	COG0456	acetyltransferase
G4Y79_RS03505	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS03510	COG5002	protein histidine kinase activity
G4Y79_RS03515	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G4Y79_RS03520	COG0494	nUDIX hydrolase
G4Y79_RS03525	COG1716	ATPase activity
G4Y79_RS03545	COG1131	(ABC) transporter
G4Y79_RS03575	COG0372	Belongs to the citrate synthase family
G4Y79_RS03650	COG0513	Belongs to the DEAD box helicase family
G4Y79_RS03655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS03680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4Y79_RS03750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G4Y79_RS03755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4Y79_RS03760	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS03770	COG2267	carboxylic ester hydrolase activity
G4Y79_RS03790	COG0488	(ABC) transporter
G4Y79_RS03800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Y79_RS03820	COG1733	regulation of RNA biosynthetic process
G4Y79_RS03840	COG1073	alpha beta
G4Y79_RS03840	COG2226	methyltransferase
G4Y79_RS03845	COG0515	serine threonine protein kinase
G4Y79_RS03845	COG2815	serine threonine protein kinase
G4Y79_RS03870	COG2133	pyrroloquinoline quinone binding
G4Y79_RS03870	COG5183	chlorophyll binding
G4Y79_RS03890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4Y79_RS03905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4Y79_RS03910	COG2009	succinate dehydrogenase
G4Y79_RS03915	COG1053	succinate dehydrogenase
G4Y79_RS03920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4Y79_RS03940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G4Y79_RS03950	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS03960	COG0470	DNA polymerase III
G4Y79_RS03965	COG1403	HNH endonuclease
G4Y79_RS03970	COG0280	phosphate acetyltransferase
G4Y79_RS03970	COG0281	malic enzyme
G4Y79_RS04015	COG1196	nuclear chromosome segregation
G4Y79_RS04015	COG0741	lytic transglycosylase activity
G4Y79_RS04015	COG0739	heme binding
G4Y79_RS04045	COG0539	negative regulation of cytoplasmic translation
G4Y79_RS04050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4Y79_RS04085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Y79_RS04110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4Y79_RS04120	COG0497	DNA recombination
G4Y79_RS04130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G4Y79_RS04135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4Y79_RS04140	COG0573	inorganic phosphate transmembrane transporter activity
G4Y79_RS04145	COG0581	inorganic phosphate transmembrane transporter activity
G4Y79_RS04150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4Y79_RS04160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4Y79_RS04165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4Y79_RS04205	COG0367	asparagine synthase
G4Y79_RS04220	COG0205	6-phosphofructokinase activity
G4Y79_RS04230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4Y79_RS04235	COG0616	signal peptide processing
G4Y79_RS04240	COG3173	Aminoglycoside phosphotransferase
G4Y79_RS04250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Y79_RS04265	COG0534	Mate efflux family protein
G4Y79_RS04290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Y79_RS04290	COG0515	serine threonine protein kinase
G4Y79_RS04320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Y79_RS04380	COG1111	helicase
G4Y79_RS04380	COG1205	dead DEAH box helicase
G4Y79_RS04385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4Y79_RS04395	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4Y79_RS04415	COG0629	single-stranded DNA binding
G4Y79_RS04440	COG2319	Wd-40 repeat
G4Y79_RS04475	COG1487	ribonuclease activity
G4Y79_RS04490	COG0328	RNA-DNA hybrid ribonuclease activity
G4Y79_RS04505	COG0587	DNA-directed DNA polymerase activity
G4Y79_RS04545	COG2894	cell division
G4Y79_RS04585	COG4249	Peptidase C14 caspase catalytic subunit p20
G4Y79_RS04585	COG2319	Wd-40 repeat
G4Y79_RS04600	COG2205	protein histidine kinase activity
G4Y79_RS04600	COG2202	Pas domain
G4Y79_RS04615	COG1175	transmembrane transport
G4Y79_RS04620	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS04625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Y79_RS04630	COG3534	alpha-L-arabinofuranosidase
G4Y79_RS04690	COG1940	carbohydrate kinase activity
G4Y79_RS04690	COG1846	Transcriptional regulator
G4Y79_RS04695	COG1175	transmembrane transport
G4Y79_RS04700	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS04710	COG1501	Belongs to the glycosyl hydrolase 31 family
G4Y79_RS04760	COG0535	radical SAM domain protein
G4Y79_RS04765	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Y79_RS04770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Y79_RS04820	COG1999	signal sequence binding
G4Y79_RS04855	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS04860	COG5002	protein histidine kinase activity
G4Y79_RS04865	COG1136	(ABC) transporter
G4Y79_RS04880	COG4213	ABC transporter substrate-binding protein
G4Y79_RS04890	COG4214	carbohydrate transport
G4Y79_RS04895	COG2197	response regulator
G4Y79_RS04905	COG2207	Transcriptional regulator
G4Y79_RS04910	COG2272	Belongs to the type-B carboxylesterase lipase family
G4Y79_RS04920	COG3119	arylsulfatase activity
G4Y79_RS04930	COG2197	response regulator
G4Y79_RS04935	COG4585	Histidine kinase
G4Y79_RS04945	COG1653	transport
G4Y79_RS04950	COG1175	transmembrane transport
G4Y79_RS04955	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS04970	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS04975	COG1609	Transcriptional regulator
G4Y79_RS04985	COG1175	transmembrane transport
G4Y79_RS04990	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS04995	COG0656	L-ascorbic acid biosynthetic process
G4Y79_RS05005	COG4977	sequence-specific DNA binding
G4Y79_RS05015	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS05020	COG1175	transmembrane transport
G4Y79_RS05050	COG2909	trisaccharide binding
G4Y79_RS05075	COG4636	protein conserved in cyanobacteria
G4Y79_RS05130	COG2319	Wd-40 repeat
G4Y79_RS05130	COG4249	Peptidase C14 caspase catalytic subunit p20
G4Y79_RS05135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4Y79_RS05295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4Y79_RS05315	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G4Y79_RS05325	COG1079	Belongs to the binding-protein-dependent transport system permease family
G4Y79_RS05330	COG4603	Belongs to the binding-protein-dependent transport system permease family
G4Y79_RS05335	COG2258	MOSC domain
G4Y79_RS05355	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G4Y79_RS05390	COG2720	vancomycin resistance protein
G4Y79_RS05400	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS05405	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS05420	COG2318	DinB family
G4Y79_RS05440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G4Y79_RS05445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4Y79_RS05450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4Y79_RS05455	COG1012	belongs to the aldehyde dehydrogenase family
G4Y79_RS05485	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS05490	COG3119	arylsulfatase activity
G4Y79_RS05500	COG3250	beta-galactosidase activity
G4Y79_RS05515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4Y79_RS05525	COG5002	protein histidine kinase activity
G4Y79_RS05530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Y79_RS05580	COG1879	ABC-type sugar transport system periplasmic component
G4Y79_RS05585	COG1609	Transcriptional regulator
G4Y79_RS05590	COG1879	ABC-type sugar transport system periplasmic component
G4Y79_RS05595	COG1129	ABC transporter
G4Y79_RS05600	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Y79_RS05605	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4Y79_RS05610	COG0784	Response regulator, receiver
G4Y79_RS05610	COG2205	protein histidine kinase activity
G4Y79_RS05610	COG5002	protein histidine kinase activity
G4Y79_RS05620	COG4565	transcriptional regulatory protein
G4Y79_RS05635	COG0596	Alpha beta hydrolase
G4Y79_RS05660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4Y79_RS05680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4Y79_RS05830	COG2154	pterin-4-alpha-carbinolamine dehydratase
G4Y79_RS05840	COG2270	Major facilitator Superfamily
G4Y79_RS05865	COG0784	Response regulator, receiver
G4Y79_RS05870	COG4999	Histidine kinase
G4Y79_RS05870	COG3850	Histidine kinase
G4Y79_RS05870	COG3437	response regulator, receiver
G4Y79_RS05870	COG2205	protein histidine kinase activity
G4Y79_RS05880	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS05885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Y79_RS05905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4Y79_RS05925	COG1376	ErfK ybiS ycfS ynhG family protein
G4Y79_RS05930	COG0346	lactoylglutathione lyase activity
G4Y79_RS05940	COG0105	UTP biosynthetic process
G4Y79_RS05980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G4Y79_RS06000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4Y79_RS06015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Y79_RS06030	COG2815	serine threonine protein kinase
G4Y79_RS06030	COG0515	serine threonine protein kinase
G4Y79_RS06040	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS06045	COG0297	glycogen (starch) synthase activity
G4Y79_RS06080	COG0012	GTP binding
G4Y79_RS06115	COG5002	protein histidine kinase activity
G4Y79_RS06120	COG0784	Response regulator, receiver
G4Y79_RS06125	COG4251	negative regulation of phosphorylation
G4Y79_RS06145	COG3622	Belongs to the hyi family
G4Y79_RS06150	COG3845	ABC transporter
G4Y79_RS06210	COG0372	Belongs to the citrate synthase family
G4Y79_RS06215	COG1051	belongs to the nudix hydrolase family
G4Y79_RS06220	COG1051	belongs to the nudix hydrolase family
G4Y79_RS06240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G4Y79_RS06270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G4Y79_RS06290	COG4948	Mandelate Racemase Muconate Lactonizing
G4Y79_RS06300	COG0489	protein tyrosine kinase activity
G4Y79_RS06340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4Y79_RS06350	COG1136	(ABC) transporter
G4Y79_RS06355	COG1136	(ABC) transporter
G4Y79_RS06375	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS06380	COG5002	protein histidine kinase activity
G4Y79_RS06385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G4Y79_RS06385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4Y79_RS06415	COG2205	protein histidine kinase activity
G4Y79_RS06415	COG0784	Response regulator, receiver
G4Y79_RS06415	COG2198	Histidine kinase
G4Y79_RS06420	COG2205	protein histidine kinase activity
G4Y79_RS06460	COG3119	arylsulfatase activity
G4Y79_RS06465	COG1368	sulfuric ester hydrolase activity
G4Y79_RS06470	COG3119	arylsulfatase activity
G4Y79_RS06475	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS06490	COG1609	Transcriptional regulator
G4Y79_RS06495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Y79_RS06500	COG0156	8-amino-7-oxononanoate synthase activity
G4Y79_RS06510	COG0477	Major facilitator Superfamily
G4Y79_RS06515	COG3842	ATPase activity
G4Y79_RS06520	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS06535	COG5183	chlorophyll binding
G4Y79_RS06535	COG2133	pyrroloquinoline quinone binding
G4Y79_RS06540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4Y79_RS06555	COG1653	transport
G4Y79_RS06570	COG3119	arylsulfatase activity
G4Y79_RS06575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Y79_RS06580	COG1486	melibiose metabolic process
G4Y79_RS06600	COG0542	response to heat
G4Y79_RS06610	COG0641	radical SAM
G4Y79_RS06625	COG0693	protein deglycase activity
G4Y79_RS06635	COG4572	Cation transport regulator
G4Y79_RS06650	COG4572	Cation transport regulator
G4Y79_RS06660	COG1285	pathogenesis
G4Y79_RS06670	COG0631	protein serine/threonine phosphatase activity
G4Y79_RS06685	COG2197	response regulator
G4Y79_RS06690	COG4585	Histidine kinase
G4Y79_RS06695	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
G4Y79_RS06705	COG3142	Participates in the control of copper homeostasis
G4Y79_RS06710	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS06720	COG1940	carbohydrate kinase activity
G4Y79_RS06745	COG4608	Belongs to the ABC transporter superfamily
G4Y79_RS06755	COG1940	carbohydrate kinase activity
G4Y79_RS06765	COG3661	Belongs to the glycosyl hydrolase 67 family
G4Y79_RS06770	COG1063	alcohol dehydrogenase
G4Y79_RS06775	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Y79_RS06785	COG0667	Aldo Keto reductase
G4Y79_RS06790	COG0587	DNA-directed DNA polymerase activity
G4Y79_RS06800	COG0740	serine-type endopeptidase activity
G4Y79_RS06805	COG1595	DNA-templated transcription, initiation
G4Y79_RS06810	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G4Y79_RS06815	COG1012	belongs to the aldehyde dehydrogenase family
G4Y79_RS06820	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G4Y79_RS06825	COG1312	Catalyzes the dehydration of D-mannonate
G4Y79_RS06840	COG3876	Protein conserved in bacteria
G4Y79_RS06845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G4Y79_RS06850	COG4608	Belongs to the ABC transporter superfamily
G4Y79_RS06855	COG0444	Belongs to the ABC transporter superfamily
G4Y79_RS06860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS06865	COG0601	transmembrane transport
G4Y79_RS06870	COG4166	transmembrane transport
G4Y79_RS06875	COG2815	serine threonine protein kinase
G4Y79_RS06875	COG0515	serine threonine protein kinase
G4Y79_RS06880	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4Y79_RS06885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G4Y79_RS06890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G4Y79_RS06895	COG0113	porphobilinogen synthase activity
G4Y79_RS06900	COG1587	Uroporphyrinogen-III synthase
G4Y79_RS06905	COG0181	hydroxymethylbilane synthase activity
G4Y79_RS06910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4Y79_RS06915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G4Y79_RS06920	COG2146	nitrite reductase [NAD(P)H] activity
G4Y79_RS06925	COG0175	sulfate reduction
G4Y79_RS06935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4Y79_RS06935	COG1648	precorrin-2 dehydrogenase activity
G4Y79_RS06945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4Y79_RS06945	COG1648	precorrin-2 dehydrogenase activity
G4Y79_RS06955	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4Y79_RS06975	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS06980	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS06985	COG1902	pentaerythritol trinitrate reductase activity
G4Y79_RS06995	COG1802	Transcriptional regulator
G4Y79_RS07000	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS07005	COG1904	glucuronate isomerase
G4Y79_RS07010	COG0246	Mannitol dehydrogenase
G4Y79_RS07015	COG2721	sulfolactate sulfo-lyase activity
G4Y79_RS07045	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS07075	COG5487	UPF0391 membrane protein
G4Y79_RS07080	COG0783	Belongs to the Dps family
G4Y79_RS07095	COG0628	permease
G4Y79_RS07105	COG5002	protein histidine kinase activity
G4Y79_RS07105	COG2198	Histidine kinase
G4Y79_RS07105	COG0784	Response regulator, receiver
G4Y79_RS07110	COG2205	protein histidine kinase activity
G4Y79_RS07120	COG1295	ribonuclease BN
G4Y79_RS07140	COG2308	Evidence 4 Homologs of previously reported genes of
G4Y79_RS07150	COG1305	Transglutaminase-like
G4Y79_RS07155	COG1609	Transcriptional regulator
G4Y79_RS07160	COG0747	negative chemotaxis
G4Y79_RS07165	COG0601	transmembrane transport
G4Y79_RS07170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS07175	COG0444	Belongs to the ABC transporter superfamily
G4Y79_RS07180	COG4608	Belongs to the ABC transporter superfamily
G4Y79_RS07205	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS07210	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS07215	COG4948	Mandelate Racemase Muconate Lactonizing
G4Y79_RS07220	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4Y79_RS07225	COG1121	(ABC) transporter
G4Y79_RS07230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4Y79_RS07235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4Y79_RS07240	COG3850	Histidine kinase
G4Y79_RS07240	COG5002	protein histidine kinase activity
G4Y79_RS07250	COG3250	beta-galactosidase activity
G4Y79_RS07255	COG1217	gtp-binding protein TYPA
G4Y79_RS07265	COG1045	serine acetyltransferase
G4Y79_RS07285	COG0473	3-isopropylmalate dehydrogenase activity
G4Y79_RS07285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G4Y79_RS07295	COG4948	Mandelate Racemase Muconate Lactonizing
G4Y79_RS07300	COG1063	alcohol dehydrogenase
G4Y79_RS07310	COG2186	Transcriptional regulator
G4Y79_RS07325	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS07340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G4Y79_RS07345	COG3386	PFAM SMP-30 Gluconolaconase
G4Y79_RS07365	COG1609	Transcriptional regulator
G4Y79_RS07375	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4Y79_RS07380	COG0154	amidase activity
G4Y79_RS07390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4Y79_RS07395	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS07410	COG1309	transcriptional regulator
G4Y79_RS07420	COG0640	Transcriptional regulator
G4Y79_RS07455	COG1716	ATPase activity
G4Y79_RS07465	COG0799	negative regulation of ribosome biogenesis
G4Y79_RS07470	COG3263	regulation of cellular component size
G4Y79_RS07480	COG0564	pseudouridine synthase activity
G4Y79_RS07485	COG5002	protein histidine kinase activity
G4Y79_RS07500	COG0484	heat shock protein binding
G4Y79_RS07505	COG0387	Pfam Sodium calcium exchanger
G4Y79_RS07515	COG3854	ATPases associated with a variety of cellular activities
G4Y79_RS07525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS07545	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G4Y79_RS07555	COG4221	oxidoreductase activity
G4Y79_RS07610	COG0739	heme binding
G4Y79_RS07660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4Y79_RS07665	COG1349	DNA-binding transcription factor activity
G4Y79_RS07670	COG1070	Carbohydrate kinase
G4Y79_RS07690	COG0667	Aldo Keto reductase
G4Y79_RS07730	COG2359	stage V sporulation protein S
G4Y79_RS07740	COG1381	Involved in DNA repair and RecF pathway recombination
G4Y79_RS07745	COG1285	pathogenesis
G4Y79_RS07770	COG0006	proline dipeptidase activity
G4Y79_RS07785	COG5002	protein histidine kinase activity
G4Y79_RS07870	COG0735	belongs to the Fur family
G4Y79_RS07895	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS07895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4Y79_RS07910	COG0730	response to heat
G4Y79_RS07920	COG0667	Aldo Keto reductase
G4Y79_RS07930	COG2062	phosphohistidine phosphatase, SixA
G4Y79_RS07935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4Y79_RS07950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4Y79_RS07995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Y79_RS07995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4Y79_RS08000	COG0662	Cupin 2, conserved barrel domain protein
G4Y79_RS08015	COG0017	Asparaginyl-tRNA synthetase
G4Y79_RS08020	COG1832	CoA-binding protein
G4Y79_RS08030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G4Y79_RS08035	COG2207	Transcriptional regulator
G4Y79_RS08035	COG1917	Cupin 2, conserved barrel domain protein
G4Y79_RS08065	COG0038	chloride channel
G4Y79_RS08070	COG2192	nodulation
G4Y79_RS08125	COG5002	protein histidine kinase activity
G4Y79_RS08125	COG2205	protein histidine kinase activity
G4Y79_RS08125	COG0784	Response regulator, receiver
G4Y79_RS08140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G4Y79_RS08150	COG0277	FAD linked oxidase domain protein
G4Y79_RS08170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4Y79_RS08175	COG0698	ribose 5-phosphate isomerase
G4Y79_RS08200	COG0802	atpase or kinase
G4Y79_RS08205	COG1214	PFAM Peptidase M22, glycoprotease
G4Y79_RS08255	COG0631	protein serine/threonine phosphatase activity
G4Y79_RS08260	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS08270	COG1794	racemase activity, acting on amino acids and derivatives
G4Y79_RS08300	COG0736	holo-[acyl-carrier-protein] synthase activity
G4Y79_RS08310	COG3340	Belongs to the peptidase S51 family
G4Y79_RS08325	COG3485	protocatechuate 3,4-dioxygenase
G4Y79_RS08340	COG4608	Belongs to the ABC transporter superfamily
G4Y79_RS08345	COG0444	Belongs to the ABC transporter superfamily
G4Y79_RS08355	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4Y79_RS08360	COG1515	deoxyribonuclease V activity
G4Y79_RS08375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4Y79_RS08390	COG0473	3-isopropylmalate dehydrogenase activity
G4Y79_RS08400	COG0768	penicillin binding
G4Y79_RS08405	COG1280	lysine exporter protein (LysE YggA)
G4Y79_RS08420	COG1950	PFAM Membrane protein of
G4Y79_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS08450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4Y79_RS08485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Y79_RS08490	COG0393	Putative heavy-metal-binding
G4Y79_RS08495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4Y79_RS08495	COG0519	Catalyzes the synthesis of GMP from XMP
G4Y79_RS08505	COG0215	cysteine-tRNA ligase activity
G4Y79_RS08510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Y79_RS08515	COG0233	cytoplasmic translational termination
G4Y79_RS08585	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
G4Y79_RS08635	COG0004	ammonium transporteR
G4Y79_RS08650	COG2816	NAD+ diphosphatase activity
G4Y79_RS08700	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G4Y79_RS08765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Y79_RS08770	COG4589	Belongs to the CDS family
G4Y79_RS08775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4Y79_RS08780	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS08785	COG1051	belongs to the nudix hydrolase family
G4Y79_RS08790	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G4Y79_RS08805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4Y79_RS08830	COG2072	flavoprotein involved in K transport
G4Y79_RS08855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4Y79_RS08865	COG0672	)-iron permease
G4Y79_RS08875	COG0672	)-iron permease
G4Y79_RS08885	COG2197	response regulator
G4Y79_RS08925	COG4659	FMN binding
G4Y79_RS08950	COG1120	ATPase activity
G4Y79_RS08960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Y79_RS08995	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4Y79_RS09000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4Y79_RS09005	COG0469	pyruvate kinase activity
G4Y79_RS09035	COG0483	inositol monophosphate 1-phosphatase activity
G4Y79_RS09040	COG1278	Cold shock
G4Y79_RS09085	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G4Y79_RS09090	COG2267	carboxylic ester hydrolase activity
G4Y79_RS09100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4Y79_RS09105	COG0612	Peptidase, M16
G4Y79_RS09145	COG2353	YceI-like domain
G4Y79_RS09150	COG0237	dephospho-CoA kinase activity
G4Y79_RS09175	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS09200	COG0823	Involved in the tonB-independent uptake of proteins
G4Y79_RS09230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Y79_RS09310	COG0300	oxidoreductase activity
G4Y79_RS09320	COG0583	DNA-binding transcription factor activity
G4Y79_RS09325	COG4221	oxidoreductase activity
G4Y79_RS09345	COG0697	spore germination
G4Y79_RS09350	COG0789	Transcriptional regulator
G4Y79_RS09365	COG1595	DNA-templated transcription, initiation
G4Y79_RS09405	COG1609	Transcriptional regulator
G4Y79_RS09415	COG1175	transmembrane transport
G4Y79_RS09425	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Y79_RS09440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G4Y79_RS09445	COG3250	beta-galactosidase activity
G4Y79_RS09450	COG1609	Transcriptional regulator
G4Y79_RS09465	COG0747	negative chemotaxis
G4Y79_RS09495	COG0489	protein tyrosine kinase activity
G4Y79_RS09500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4Y79_RS09505	COG4988	ABC transporter
G4Y79_RS09510	COG1294	oxidase, subunit
G4Y79_RS09515	COG1271	oxidase subunit
G4Y79_RS09520	COG1486	melibiose metabolic process
G4Y79_RS09530	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS09535	COG1175	transmembrane transport
G4Y79_RS09585	COG2205	protein histidine kinase activity
G4Y79_RS09590	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS09595	COG0531	amino acid
G4Y79_RS09605	COG1175	transmembrane transport
G4Y79_RS09610	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS09615	COG0004	ammonium transporteR
G4Y79_RS09620	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G4Y79_RS09625	COG0823	Involved in the tonB-independent uptake of proteins
G4Y79_RS09625	COG4946	Tricorn protease homolog
G4Y79_RS09625	COG1506	peptidase
G4Y79_RS09640	COG4948	Mandelate Racemase Muconate Lactonizing
G4Y79_RS09645	COG0456	acetyltransferase
G4Y79_RS09665	COG0601	transmembrane transport
G4Y79_RS09670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS09685	COG0523	cobalamin synthesis protein
G4Y79_RS09690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4Y79_RS09695	COG1121	(ABC) transporter
G4Y79_RS09700	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4Y79_RS09720	COG0402	S-adenosylhomocysteine deaminase activity
G4Y79_RS09725	COG0583	DNA-binding transcription factor activity
G4Y79_RS09750	COG1573	uracil-dna glycosylase
G4Y79_RS09760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G4Y79_RS09795	COG0405	Gamma-glutamyltransferase
G4Y79_RS09805	COG4977	sequence-specific DNA binding
G4Y79_RS09810	COG0384	phenazine biosynthesis protein PhzF
G4Y79_RS09830	COG3964	amidohydrolase
G4Y79_RS09835	COG3942	CHAP domain
G4Y79_RS09835	COG1388	LysM domain
G4Y79_RS09850	COG0305	Participates in initiation and elongation during chromosome replication
G4Y79_RS09860	COG1484	DNA-dependent DNA replication
G4Y79_RS09870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4Y79_RS09900	COG0835	chemotaxis
G4Y79_RS09915	COG2201	protein-glutamate methylesterase activity
G4Y79_RS09935	COG0835	chemotaxis
G4Y79_RS09940	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
G4Y79_RS09945	COG1609	Transcriptional regulator
G4Y79_RS09955	COG0601	transmembrane transport
G4Y79_RS09965	COG0444	Belongs to the ABC transporter superfamily
G4Y79_RS09980	COG3408	Glycogen debranching enzyme
G4Y79_RS09985	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Y79_RS09990	COG2272	Belongs to the type-B carboxylesterase lipase family
G4Y79_RS10010	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G4Y79_RS10035	COG2197	response regulator
G4Y79_RS10040	COG4585	Histidine kinase
G4Y79_RS10045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4Y79_RS10055	COG3958	Transketolase
G4Y79_RS10060	COG3959	Transketolase, thiamine diphosphate binding domain
G4Y79_RS10075	COG1053	succinate dehydrogenase
G4Y79_RS10085	COG0326	Molecular chaperone. Has ATPase activity
G4Y79_RS10100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4Y79_RS10105	COG1609	Transcriptional regulator
G4Y79_RS10110	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Y79_RS10115	COG5297	Belongs to the glycosyl hydrolase family 6
G4Y79_RS10115	COG2273	Hydrolase Family 16
G4Y79_RS10150	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4Y79_RS10155	COG0129	dihydroxy-acid dehydratase activity
G4Y79_RS10185	COG3850	Histidine kinase
G4Y79_RS10185	COG3437	response regulator, receiver
G4Y79_RS10185	COG4999	Histidine kinase
G4Y79_RS10185	COG2205	protein histidine kinase activity
G4Y79_RS10230	COG1490	D-aminoacyl-tRNA deacylase activity
G4Y79_RS10250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Y79_RS10265	COG0009	L-threonylcarbamoyladenylate synthase
G4Y79_RS10275	COG0686	Belongs to the AlaDH PNT family
G4Y79_RS10290	COG0427	acetyl-CoA hydrolase
G4Y79_RS10300	COG1595	DNA-templated transcription, initiation
G4Y79_RS10310	COG0085	RNA polymerase activity
G4Y79_RS10320	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS10340	COG0752	glycyl-tRNA synthetase alpha subunit
G4Y79_RS10340	COG0751	glycine-tRNA ligase activity
G4Y79_RS10345	COG0305	Participates in initiation and elongation during chromosome replication
G4Y79_RS10345	COG0358	DNA primase activity
G4Y79_RS10355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Y79_RS10380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Y79_RS10385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Y79_RS10390	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Y79_RS10395	COG0649	NAD binding
G4Y79_RS10415	COG1034	ATP synthesis coupled electron transport
G4Y79_RS10420	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G4Y79_RS10425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Y79_RS10430	COG0839	Belongs to the complex I subunit 6 family
G4Y79_RS10435	COG0713	ATP synthesis coupled electron transport
G4Y79_RS10450	COG1007	ATP synthesis coupled electron transport
G4Y79_RS10465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G4Y79_RS10470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4Y79_RS10475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4Y79_RS10480	COG0193	aminoacyl-tRNA hydrolase activity
G4Y79_RS10495	COG1132	(ABC) transporter
G4Y79_RS10520	COG1131	(ABC) transporter
G4Y79_RS10550	COG1309	transcriptional regulator
G4Y79_RS10565	COG1231	oxidoreductase activity
G4Y79_RS10595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G4Y79_RS10600	COG0049	tRNA binding
G4Y79_RS10605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4Y79_RS10610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4Y79_RS10615	COG0051	transcription antitermination factor activity, RNA binding
G4Y79_RS10620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G4Y79_RS10625	COG0088	Forms part of the polypeptide exit tunnel
G4Y79_RS10630	COG0089	rRNA binding
G4Y79_RS10635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4Y79_RS10640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G4Y79_RS10645	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G4Y79_RS10650	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G4Y79_RS10655	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G4Y79_RS10660	COG0255	Belongs to the universal ribosomal protein uL29 family
G4Y79_RS10665	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G4Y79_RS10670	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G4Y79_RS10675	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G4Y79_RS10680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4Y79_RS10690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G4Y79_RS10695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G4Y79_RS10700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4Y79_RS10705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G4Y79_RS10710	COG1841	ribosomal large subunit assembly
G4Y79_RS10715	COG0200	Binds to the 23S rRNA
G4Y79_RS10725	COG0563	adenylate kinase activity
G4Y79_RS10740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4Y79_RS10755	COG0202	RNA polymerase activity
G4Y79_RS10775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G4Y79_RS10790	COG3956	TIGRFAM MazG family protein
G4Y79_RS10825	COG0859	PFAM glycosyl transferase family 9
G4Y79_RS10830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G4Y79_RS10830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4Y79_RS10840	COG3695	enzyme binding
G4Y79_RS10845	COG1418	mRNA catabolic process
G4Y79_RS10850	COG2137	regulation of response to DNA damage stimulus
G4Y79_RS10855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Y79_RS10875	COG0287	Prephenate dehydrogenase
G4Y79_RS10885	COG1994	Peptidase M50
G4Y79_RS10890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4Y79_RS10895	COG2329	Antibiotic biosynthesis monooxygenase
G4Y79_RS10900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4Y79_RS10915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4Y79_RS10920	COG5002	protein histidine kinase activity
G4Y79_RS10930	COG5002	protein histidine kinase activity
G4Y79_RS10935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Y79_RS10940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4Y79_RS10945	COG0784	Response regulator, receiver
G4Y79_RS10945	COG2198	Histidine kinase
G4Y79_RS10945	COG2205	protein histidine kinase activity
G4Y79_RS10955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G4Y79_RS10990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS11005	COG2897	thiosulfate sulfurtransferase activity
G4Y79_RS11030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G4Y79_RS11035	COG1480	7TM receptor with intracellular HD hydrolase
G4Y79_RS11040	COG1610	YqeY-like protein
G4Y79_RS11045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Y79_RS11060	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS11090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G4Y79_RS11095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G4Y79_RS11100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Y79_RS11105	COG0589	response to stress
G4Y79_RS11110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4Y79_RS11115	COG4585	Histidine kinase
G4Y79_RS11125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G4Y79_RS11135	COG1716	ATPase activity
G4Y79_RS11140	COG1136	(ABC) transporter
G4Y79_RS11145	COG0517	IMP dehydrogenase activity
G4Y79_RS11150	COG0517	IMP dehydrogenase activity
G4Y79_RS11160	COG2197	response regulator
G4Y79_RS11165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G4Y79_RS11170	COG0456	acetyltransferase
G4Y79_RS11175	COG2814	Major facilitator Superfamily
G4Y79_RS11200	COG1960	acyl-CoA dehydrogenase activity
G4Y79_RS11215	COG0613	PHP domain protein
G4Y79_RS11220	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS11225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4Y79_RS11230	COG1234	tRNA 3'-trailer cleavage
G4Y79_RS11240	COG4555	ABC transporter
G4Y79_RS11245	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS11250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G4Y79_RS11255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4Y79_RS11285	COG1073	alpha beta
G4Y79_RS11310	COG0517	IMP dehydrogenase activity
G4Y79_RS11320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G4Y79_RS11325	COG3639	organic phosphonate transmembrane transporter activity
G4Y79_RS11330	COG1132	(ABC) transporter
G4Y79_RS11335	COG1132	(ABC) transporter
G4Y79_RS11345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS11355	COG0823	Involved in the tonB-independent uptake of proteins
G4Y79_RS11355	COG4946	Tricorn protease homolog
G4Y79_RS11355	COG1506	peptidase
G4Y79_RS11365	COG0747	negative chemotaxis
G4Y79_RS11370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS11375	COG0601	transmembrane transport
G4Y79_RS11385	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS11390	COG2205	protein histidine kinase activity
G4Y79_RS11410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Y79_RS11420	COG1653	transport
G4Y79_RS11425	COG1175	transmembrane transport
G4Y79_RS11430	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS11450	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS11455	COG2205	protein histidine kinase activity
G4Y79_RS11455	COG5002	protein histidine kinase activity
G4Y79_RS11455	COG0784	Response regulator, receiver
G4Y79_RS11470	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS11510	COG4251	negative regulation of phosphorylation
G4Y79_RS11515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS11520	COG0601	transmembrane transport
G4Y79_RS11535	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS11540	COG1175	transmembrane transport
G4Y79_RS11550	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS11555	COG2205	protein histidine kinase activity
G4Y79_RS11555	COG2202	Pas domain
G4Y79_RS11565	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS11570	COG1175	transmembrane transport
G4Y79_RS11575	COG1609	Transcriptional regulator
G4Y79_RS11580	COG3250	beta-galactosidase activity
G4Y79_RS11585	COG1053	succinate dehydrogenase
G4Y79_RS11590	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
G4Y79_RS11615	COG1609	Transcriptional regulator
G4Y79_RS11625	COG1175	transmembrane transport
G4Y79_RS11630	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS11635	COG3119	arylsulfatase activity
G4Y79_RS11660	COG3842	ATPase activity
G4Y79_RS11665	COG1555	photosystem II stabilization
G4Y79_RS11670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4Y79_RS11680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G4Y79_RS11700	COG0384	phenazine biosynthesis protein PhzF
G4Y79_RS11710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4Y79_RS11715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4Y79_RS11725	COG0463	Glycosyl transferase, family 2
G4Y79_RS11735	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G4Y79_RS11775	COG1917	Cupin 2, conserved barrel domain protein
G4Y79_RS11775	COG2207	Transcriptional regulator
G4Y79_RS11790	COG1175	transmembrane transport
G4Y79_RS11795	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS11800	COG1473	amidohydrolase
G4Y79_RS11815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4Y79_RS11820	COG2226	methyltransferase
G4Y79_RS11825	COG0640	Transcriptional regulator
G4Y79_RS11840	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS11870	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G4Y79_RS11880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4Y79_RS11880	COG0189	ligase activity
G4Y79_RS11890	COG1091	dTDP-4-dehydrorhamnose reductase activity
G4Y79_RS11895	COG1216	Glycosyl transferase, family 2
G4Y79_RS11900	COG0463	Glycosyl transferase, family 2
G4Y79_RS11905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4Y79_RS11910	COG2226	methyltransferase
G4Y79_RS11930	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G4Y79_RS11935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4Y79_RS11945	COG1088	dTDP-glucose 4,6-dehydratase activity
G4Y79_RS11950	COG0561	phosphatase activity
G4Y79_RS11960	COG0489	protein tyrosine kinase activity
G4Y79_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS11970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4Y79_RS11985	COG1054	Belongs to the UPF0176 family
G4Y79_RS11990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4Y79_RS12020	COG1042	CoA-binding domain protein
G4Y79_RS12020	COG0045	succinate-CoA ligase (ADP-forming) activity
G4Y79_RS12020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS12025	COG1320	monovalent cation:proton antiporter activity
G4Y79_RS12030	COG2212	antiporter activity
G4Y79_RS12035	COG1863	multisubunit Na H antiporter MnhE subunit
G4Y79_RS12040	COG0651	ATP synthesis coupled electron transport
G4Y79_RS12045	COG1006	Multisubunit Na H antiporter MnhC subunit
G4Y79_RS12050	COG2111	Na H antiporter
G4Y79_RS12050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4Y79_RS12055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4Y79_RS12100	COG1960	acyl-CoA dehydrogenase activity
G4Y79_RS12145	COG0372	Belongs to the citrate synthase family
G4Y79_RS12205	COG2770	Histidine kinase
G4Y79_RS12205	COG2208	phosphoserine phosphatase activity
G4Y79_RS12210	COG0494	nUDIX hydrolase
G4Y79_RS12215	COG0628	permease
G4Y79_RS12245	COG3191	aminopeptidase activity
G4Y79_RS12250	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS12260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4Y79_RS12265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4Y79_RS12270	COG1116	anion transmembrane transporter activity
G4Y79_RS12280	COG5002	protein histidine kinase activity
G4Y79_RS12285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Y79_RS12295	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS12310	COG3685	Protein conserved in bacteria
G4Y79_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS12325	COG1523	belongs to the glycosyl hydrolase 13 family
G4Y79_RS12355	COG1918	ferrous iron import across plasma membrane
G4Y79_RS12365	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G4Y79_RS12365	COG1918	ferrous iron import across plasma membrane
G4Y79_RS12385	COG0583	DNA-binding transcription factor activity
G4Y79_RS12400	COG2197	response regulator
G4Y79_RS12405	COG4585	Histidine kinase
G4Y79_RS12410	COG0583	DNA-binding transcription factor activity
G4Y79_RS12415	COG2855	membrane
G4Y79_RS12420	COG1053	succinate dehydrogenase
G4Y79_RS12425	COG1233	COG1233 Phytoene dehydrogenase and related
G4Y79_RS12430	COG2186	Transcriptional regulator
G4Y79_RS12435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4Y79_RS12450	COG0601	transmembrane transport
G4Y79_RS12455	COG2186	Transcriptional regulator
G4Y79_RS12460	COG2207	Transcriptional regulator
G4Y79_RS12460	COG1917	Cupin 2, conserved barrel domain protein
G4Y79_RS12490	COG1053	succinate dehydrogenase
G4Y79_RS12495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4Y79_RS12495	COG2124	cytochrome p450
G4Y79_RS12500	COG1309	transcriptional regulator
G4Y79_RS12550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4Y79_RS12560	COG0667	Aldo Keto reductase
G4Y79_RS12570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4Y79_RS12585	COG1307	EDD domain protein, DegV family
G4Y79_RS12590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4Y79_RS12595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G4Y79_RS12620	COG1295	ribonuclease BN
G4Y79_RS12620	COG1959	2 iron, 2 sulfur cluster binding
G4Y79_RS12635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4Y79_RS12640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4Y79_RS12640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4Y79_RS12655	COG0674	pyruvate-flavodoxin oxidoreductase activity
G4Y79_RS12655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G4Y79_RS12670	COG1428	Deoxynucleoside kinase
G4Y79_RS12695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4Y79_RS12700	COG2226	methyltransferase
G4Y79_RS12705	COG0583	DNA-binding transcription factor activity
G4Y79_RS12715	COG0537	adenosine 5'-monophosphoramidase activity
G4Y79_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS12725	COG4946	Tricorn protease homolog
G4Y79_RS12725	COG0823	Involved in the tonB-independent uptake of proteins
G4Y79_RS12725	COG1506	peptidase
G4Y79_RS12735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4Y79_RS12760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4Y79_RS12765	COG1040	competence protein
G4Y79_RS12785	COG2197	response regulator
G4Y79_RS12810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G4Y79_RS12815	COG0762	integral membrane protein
G4Y79_RS12875	COG1733	regulation of RNA biosynthetic process
G4Y79_RS12895	COG4191	Histidine kinase
G4Y79_RS12900	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS12920	COG0667	Aldo Keto reductase
G4Y79_RS12925	COG4604	ABC transporter, ATP-binding protein
G4Y79_RS12930	COG4605	iron ion homeostasis
G4Y79_RS12935	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4Y79_RS12940	COG4607	ABC-type enterochelin transport system periplasmic component
G4Y79_RS12980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Y79_RS13000	COG0617	tRNA 3'-terminal CCA addition
G4Y79_RS13000	COG3620	sequence-specific DNA binding
G4Y79_RS13000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G4Y79_RS13035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G4Y79_RS13065	COG2188	Transcriptional regulator
G4Y79_RS13070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS13075	COG0601	transmembrane transport
G4Y79_RS13090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G4Y79_RS13105	COG0601	transmembrane transport
G4Y79_RS13110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS13115	COG0747	negative chemotaxis
G4Y79_RS13120	COG0601	transmembrane transport
G4Y79_RS13125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS13130	COG0606	chelatase, subunit chli
G4Y79_RS13150	COG3001	Fructosamine kinase
G4Y79_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS13210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4Y79_RS13225	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G4Y79_RS13230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4Y79_RS13235	COG0204	Acyl-transferase
G4Y79_RS13240	COG1187	pseudouridine synthase activity
G4Y79_RS13250	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS13265	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4Y79_RS13270	COG1253	flavin adenine dinucleotide binding
G4Y79_RS13275	COG0741	lytic transglycosylase activity
G4Y79_RS13275	COG1196	nuclear chromosome segregation
G4Y79_RS13275	COG0739	heme binding
G4Y79_RS13280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4Y79_RS13285	COG0596	Alpha beta hydrolase
G4Y79_RS13300	COG2313	pseudouridylate synthase activity
G4Y79_RS13320	COG2135	peptidase activity
G4Y79_RS13325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4Y79_RS13330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4Y79_RS13335	COG1674	ftsk spoiiie
G4Y79_RS13335	COG4980	gas vesicle protein
G4Y79_RS13360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Y79_RS13380	COG1131	(ABC) transporter
G4Y79_RS13385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G4Y79_RS13390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4Y79_RS13395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Y79_RS13400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G4Y79_RS13405	COG0505	Belongs to the CarA family
G4Y79_RS13410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4Y79_RS13425	COG0443	Heat shock 70 kDa protein
G4Y79_RS13430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4Y79_RS13445	COG0617	tRNA 3'-terminal CCA addition
G4Y79_RS13450	COG0742	ribosomal rna small subunit methyltransferase
G4Y79_RS13480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4Y79_RS13515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G4Y79_RS13520	COG2508	Transcriptional regulator
G4Y79_RS13525	COG0069	glutamate synthase activity
G4Y79_RS13525	COG0070	glutamate synthase
G4Y79_RS13525	COG0067	glutamate synthase
G4Y79_RS13530	COG2508	Transcriptional regulator
G4Y79_RS13545	COG1316	TRANSCRIPTIONal
G4Y79_RS13570	COG0594	ribonuclease P activity
G4Y79_RS13575	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G4Y79_RS13585	COG0706	membrane insertase activity
G4Y79_RS13590	COG1847	R3H domain protein
G4Y79_RS13600	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G4Y79_RS13610	COG0556	nucleotide-excision repair
G4Y79_RS13625	COG0019	diaminopimelate decarboxylase activity
G4Y79_RS13630	COG1160	GTP binding
G4Y79_RS13635	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G4Y79_RS13640	COG1285	pathogenesis
G4Y79_RS13650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Y79_RS13685	COG0095	Lipoate-protein ligase
G4Y79_RS13695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4Y79_RS13700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4Y79_RS13710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G4Y79_RS13710	COG1796	DNA polymerase
G4Y79_RS13725	COG0512	Glutamine amidotransferase of anthranilate synthase
G4Y79_RS13725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4Y79_RS13740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4Y79_RS13745	COG0134	indole-3-glycerol-phosphate synthase activity
G4Y79_RS13750	COG0135	phosphoribosylanthranilate isomerase activity
G4Y79_RS13760	COG0133	tryptophan synthase activity
G4Y79_RS13770	COG0159	tryptophan synthase activity
G4Y79_RS13780	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4Y79_RS13785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4Y79_RS13795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4Y79_RS13800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G4Y79_RS13805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4Y79_RS13810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G4Y79_RS13825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G4Y79_RS13835	COG0460	homoserine dehydrogenase
G4Y79_RS13835	COG0527	aspartate kinase activity
G4Y79_RS13840	COG1774	PSP1 C-terminal conserved region
G4Y79_RS13845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Y79_RS13850	COG1473	amidohydrolase
G4Y79_RS13860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4Y79_RS13865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4Y79_RS13870	COG5002	protein histidine kinase activity
G4Y79_RS13880	COG1612	heme a metabolic process
G4Y79_RS13885	COG0109	protoheme IX farnesyltransferase activity
G4Y79_RS13885	COG1612	heme a metabolic process
G4Y79_RS13895	COG1293	RNA-binding protein homologous to eukaryotic snRNP
G4Y79_RS13900	COG2326	polyphosphate kinase activity
G4Y79_RS13905	COG0859	PFAM glycosyl transferase family 9
G4Y79_RS13910	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS13935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Y79_RS13935	COG0515	serine threonine protein kinase
G4Y79_RS13940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4Y79_RS13945	COG4948	Mandelate Racemase Muconate Lactonizing
G4Y79_RS13955	COG1312	Catalyzes the dehydration of D-mannonate
G4Y79_RS13960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4Y79_RS13965	COG0667	Aldo Keto reductase
G4Y79_RS13980	COG1595	DNA-templated transcription, initiation
G4Y79_RS13995	COG2814	Major facilitator Superfamily
G4Y79_RS14000	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS14005	COG1175	transmembrane transport
G4Y79_RS14025	COG4977	sequence-specific DNA binding
G4Y79_RS14040	COG0667	Aldo Keto reductase
G4Y79_RS14095	COG2197	response regulator
G4Y79_RS14105	COG2217	Heavy metal translocating P-type atpase
G4Y79_RS14145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Y79_RS14155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Y79_RS14160	COG0662	Cupin 2, conserved barrel domain protein
G4Y79_RS14160	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G4Y79_RS14165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4Y79_RS14165	COG0758	DNA mediated transformation
G4Y79_RS14170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4Y79_RS14175	COG1837	Belongs to the UPF0109 family
G4Y79_RS14180	COG0228	four-way junction DNA binding
G4Y79_RS14185	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4Y79_RS14190	COG2814	Major facilitator Superfamily
G4Y79_RS14195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G4Y79_RS14200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Y79_RS14210	COG0728	peptidoglycan biosynthetic process
G4Y79_RS14230	COG0772	Belongs to the SEDS family
G4Y79_RS14235	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4Y79_RS14240	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS14250	COG5001	Diguanylate cyclase
G4Y79_RS14250	COG1716	ATPase activity
G4Y79_RS14260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4Y79_RS14265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4Y79_RS14270	COG0629	single-stranded DNA binding
G4Y79_RS14275	COG0360	Binds together with S18 to 16S ribosomal RNA
G4Y79_RS14295	COG1216	Glycosyl transferase, family 2
G4Y79_RS14300	COG0084	hydrolase, TatD family'
G4Y79_RS14325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G4Y79_RS14330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Y79_RS14365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4Y79_RS14370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G4Y79_RS14380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4Y79_RS14385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4Y79_RS14395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Y79_RS14400	COG1690	Belongs to the RtcB family
G4Y79_RS14405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G4Y79_RS14420	COG0793	Belongs to the peptidase S41A family
G4Y79_RS14420	COG3409	Peptidoglycan-binding domain 1 protein
G4Y79_RS14435	COG4143	(ABC) transporter
G4Y79_RS14440	COG1178	ABC-type Fe3 transport system permease component
G4Y79_RS14445	COG3842	ATPase activity
G4Y79_RS14450	COG2723	6-phospho-beta-galactosidase activity
G4Y79_RS14455	COG0187	DNA topoisomerase II activity
G4Y79_RS14465	COG1192	Involved in chromosome partitioning
G4Y79_RS14530	COG2052	Domain of unknown function (DUF370)
G4Y79_RS14635	COG1053	succinate dehydrogenase
G4Y79_RS14645	COG2197	response regulator
G4Y79_RS14665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Y79_RS14675	COG1138	Cytochrome C-type biogenesis protein
G4Y79_RS14690	COG0318	PFAM AMP-dependent synthetase and ligase
G4Y79_RS14695	COG0824	Thioesterase
G4Y79_RS14705	COG0107	imidazoleglycerol-phosphate synthase activity
G4Y79_RS14710	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G4Y79_RS14715	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4Y79_RS14730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G4Y79_RS14735	COG2815	serine threonine protein kinase
G4Y79_RS14735	COG0515	serine threonine protein kinase
G4Y79_RS14740	COG1705	Flagellar rod assembly protein muramidase FlgJ
G4Y79_RS14740	COG1388	LysM domain
G4Y79_RS14780	COG1862	Preprotein translocase
G4Y79_RS14785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4Y79_RS14790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4Y79_RS14795	COG5002	protein histidine kinase activity
G4Y79_RS14800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4Y79_RS14805	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS14810	COG5002	protein histidine kinase activity
G4Y79_RS14815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4Y79_RS14840	COG0525	valine-tRNA ligase activity
G4Y79_RS14845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4Y79_RS14860	COG0138	bifunctional purine biosynthesis protein purh
G4Y79_RS14885	COG2192	nodulation
G4Y79_RS14900	COG2897	thiosulfate sulfurtransferase activity
G4Y79_RS14910	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS14920	COG0137	argininosuccinate synthase activity
G4Y79_RS14925	COG0165	Argininosuccinate lyase
G4Y79_RS14930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4Y79_RS14935	COG0028	Belongs to the TPP enzyme family
G4Y79_RS14940	COG0440	acetolactate synthase activity
G4Y79_RS14945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4Y79_RS14950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4Y79_RS14955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4Y79_RS14960	COG0778	Nitroreductase
G4Y79_RS14965	COG0066	3-isopropylmalate dehydratase activity
G4Y79_RS14970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4Y79_RS14990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4Y79_RS14995	COG0626	cystathionine gamma-synthase activity
G4Y79_RS15000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4Y79_RS15005	COG0083	homoserine kinase activity
G4Y79_RS15010	COG1012	belongs to the aldehyde dehydrogenase family
G4Y79_RS15020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Y79_RS15025	COG0649	NAD binding
G4Y79_RS15035	COG0489	protein tyrosine kinase activity
G4Y79_RS15065	COG5002	protein histidine kinase activity
G4Y79_RS15075	COG1316	TRANSCRIPTIONal
G4Y79_RS15085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS15090	COG0601	transmembrane transport
G4Y79_RS15095	COG0747	negative chemotaxis
G4Y79_RS15115	COG1192	Involved in chromosome partitioning
G4Y79_RS15375	COG0582	viral genome integration into host DNA
G4Y79_RS15410	COG2151	metal-sulfur cluster biosynthetic enzyme
G4Y79_RS15415	COG0396	ATPase activity
G4Y79_RS15420	COG0719	Fe-S assembly protein
G4Y79_RS15425	COG0719	Fe-S assembly protein
G4Y79_RS15430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4Y79_RS15435	COG0822	iron-sulfur transferase activity
G4Y79_RS15445	COG0584	glycerophosphoryl diester phosphodiesterase
G4Y79_RS15450	COG2226	methyltransferase
G4Y79_RS15485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4Y79_RS15485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G4Y79_RS15500	COG1011	Hydrolase
G4Y79_RS15510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4Y79_RS15510	COG1199	ATP-dependent helicase activity
G4Y79_RS15520	COG2346	COG2346, Truncated hemoglobins
G4Y79_RS15535	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
G4Y79_RS15540	COG0632	four-way junction helicase activity
G4Y79_RS15545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G4Y79_RS15550	COG0217	transcriptional regulatory protein
G4Y79_RS15560	COG2003	Belongs to the UPF0758 family
G4Y79_RS15575	COG0148	phosphopyruvate hydratase activity
G4Y79_RS15580	COG1104	cysteine desulfurase activity
G4Y79_RS15585	COG0482	sulfurtransferase activity
G4Y79_RS15635	COG0739	heme binding
G4Y79_RS15645	COG1388	LysM domain
G4Y79_RS15645	COG3942	CHAP domain
G4Y79_RS15650	COG1550	Protein conserved in bacteria
G4Y79_RS15670	COG2304	oxidoreductase activity
G4Y79_RS15690	COG0714	Associated with various cellular activities
G4Y79_RS15695	COG1435	thymidine kinase activity
G4Y79_RS15710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4Y79_RS15730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4Y79_RS15735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4Y79_RS15745	COG0149	triose-phosphate isomerase activity
G4Y79_RS15750	COG2815	serine threonine protein kinase
G4Y79_RS15750	COG0515	serine threonine protein kinase
G4Y79_RS15760	COG0126	phosphoglycerate kinase activity
G4Y79_RS15760	COG0149	triose-phosphate isomerase activity
G4Y79_RS15765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4Y79_RS15770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4Y79_RS15790	COG0714	Associated with various cellular activities
G4Y79_RS15800	COG0504	CTP synthase activity
G4Y79_RS15810	COG0443	Heat shock 70 kDa protein
G4Y79_RS15820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4Y79_RS15825	COG2084	Dehydrogenase
G4Y79_RS15835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4Y79_RS15880	COG0631	protein serine/threonine phosphatase activity
G4Y79_RS15885	COG0515	serine threonine protein kinase
G4Y79_RS15890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4Y79_RS15900	COG1304	FMN binding
G4Y79_RS15905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Y79_RS15920	COG1607	acyl-coa hydrolase
G4Y79_RS15925	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS15940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Y79_RS15960	COG2890	protein-(glutamine-N5) methyltransferase activity
G4Y79_RS15975	COG5002	protein histidine kinase activity
G4Y79_RS15990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4Y79_RS16005	COG0416	fatty acid biosynthetic process
G4Y79_RS16020	COG4191	Histidine kinase
G4Y79_RS16025	COG0793	Belongs to the peptidase S41A family
G4Y79_RS16030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4Y79_RS16055	COG1739	Uncharacterized protein family UPF0029
G4Y79_RS16075	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G4Y79_RS16080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4Y79_RS16090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4Y79_RS16110	COG0316	Belongs to the HesB IscA family
G4Y79_RS16120	COG3409	Peptidoglycan-binding domain 1 protein
G4Y79_RS16120	COG5632	N-Acetylmuramoyl-L-alanine amidase
G4Y79_RS16150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G4Y79_RS16150	COG0546	phosphoglycolate phosphatase activity
G4Y79_RS16155	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G4Y79_RS16165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS16170	COG0601	transmembrane transport
G4Y79_RS16175	COG0747	negative chemotaxis
G4Y79_RS16195	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G4Y79_RS16200	COG0481	GTPase activity
G4Y79_RS16215	COG1058	Belongs to the CinA family
G4Y79_RS16215	COG1546	Belongs to the CinA family
G4Y79_RS16220	COG3842	ATPase activity
G4Y79_RS16260	COG0156	8-amino-7-oxononanoate synthase activity
G4Y79_RS16265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4Y79_RS16270	COG1132	(ABC) transporter
G4Y79_RS16275	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
G4Y79_RS16275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4Y79_RS16300	COG0667	Aldo Keto reductase
G4Y79_RS16315	COG1136	(ABC) transporter
G4Y79_RS16325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Y79_RS16330	COG1174	glycine betaine transport
G4Y79_RS16340	COG1174	glycine betaine transport
G4Y79_RS16360	COG0444	Belongs to the ABC transporter superfamily
G4Y79_RS16365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS16370	COG0601	transmembrane transport
G4Y79_RS16375	COG0747	negative chemotaxis
G4Y79_RS16380	COG1609	Transcriptional regulator
G4Y79_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS16420	COG4191	Histidine kinase
G4Y79_RS16425	COG0784	Response regulator, receiver
G4Y79_RS16450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4Y79_RS16455	COG4297	protein containing double-stranded beta helix domain
G4Y79_RS16460	COG4106	trans-aconitate 2-methyltransferase activity
G4Y79_RS16485	COG1175	transmembrane transport
G4Y79_RS16490	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS16530	COG0577	efflux transmembrane transporter activity
G4Y79_RS16535	COG1136	(ABC) transporter
G4Y79_RS16545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Y79_RS16555	COG4585	Histidine kinase
G4Y79_RS16560	COG2197	response regulator
G4Y79_RS16570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS16580	COG1254	Belongs to the acylphosphatase family
G4Y79_RS16585	COG3534	alpha-L-arabinofuranosidase
G4Y79_RS16595	COG1653	transport
G4Y79_RS16600	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS16605	COG1175	transmembrane transport
G4Y79_RS16615	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS16620	COG1175	transmembrane transport
G4Y79_RS16665	COG2319	Wd-40 repeat
G4Y79_RS16665	COG3903	Transcriptional regulator
G4Y79_RS16675	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS16680	COG1175	transmembrane transport
G4Y79_RS16695	COG1082	Xylose isomerase domain protein TIM barrel
G4Y79_RS16700	COG2186	Transcriptional regulator
G4Y79_RS16710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS16715	COG0601	transmembrane transport
G4Y79_RS16730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Y79_RS16865	COG2909	trisaccharide binding
G4Y79_RS16900	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS16905	COG1414	Transcriptional regulator
G4Y79_RS16915	COG3718	enzyme involved in inositol metabolism
G4Y79_RS16920	COG3962	Belongs to the TPP enzyme family
G4Y79_RS16925	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS16930	COG3684	Belongs to the aldolase LacD family
G4Y79_RS16945	COG1703	isobutyryl-CoA mutase activity
G4Y79_RS16955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G4Y79_RS16960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4Y79_RS16970	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Y79_RS16975	COG0567	Dehydrogenase, E1 component
G4Y79_RS16985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G4Y79_RS16995	COG1136	(ABC) transporter
G4Y79_RS17000	COG1136	(ABC) transporter
G4Y79_RS17015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G4Y79_RS17020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G4Y79_RS17025	COG0363	glucosamine-6-phosphate deaminase activity
G4Y79_RS17030	COG0540	Belongs to the ATCase OTCase family
G4Y79_RS17035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4Y79_RS17040	COG0167	dihydroorotate dehydrogenase activity
G4Y79_RS17045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G4Y79_RS17050	COG0284	orotidine-5'-phosphate decarboxylase activity
G4Y79_RS17065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4Y79_RS17070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Y79_RS17085	COG0415	Belongs to the DNA photolyase family
G4Y79_RS17100	COG0039	L-malate dehydrogenase activity
G4Y79_RS17105	COG1562	ergosterol biosynthetic process
G4Y79_RS17130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4Y79_RS17145	COG0123	including yeast histone deacetylase and acetoin utilization protein
G4Y79_RS17150	COG1012	belongs to the aldehyde dehydrogenase family
G4Y79_RS17150	COG2030	dehydratase
G4Y79_RS17165	COG3850	Histidine kinase
G4Y79_RS17165	COG3437	response regulator, receiver
G4Y79_RS17165	COG4999	Histidine kinase
G4Y79_RS17165	COG2205	protein histidine kinase activity
G4Y79_RS17170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G4Y79_RS17175	COG0792	nuclease activity
G4Y79_RS17180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4Y79_RS17190	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS17195	COG2205	protein histidine kinase activity
G4Y79_RS17195	COG0784	Response regulator, receiver
G4Y79_RS17200	COG5002	protein histidine kinase activity
G4Y79_RS17230	COG0402	S-adenosylhomocysteine deaminase activity
G4Y79_RS17245	COG0571	ribonuclease III activity
G4Y79_RS17250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Y79_RS17255	COG0314	molybdopterin synthase activity
G4Y79_RS17260	COG0315	cyclic pyranopterin monophosphate synthase activity
G4Y79_RS17265	COG0552	protein localization to endoplasmic reticulum
G4Y79_RS17275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G4Y79_RS17290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4Y79_RS17300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4Y79_RS17315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4Y79_RS17320	COG0303	'Molybdopterin
G4Y79_RS17330	COG2183	response to ionizing radiation
G4Y79_RS17330	COG0539	negative regulation of cytoplasmic translation
G4Y79_RS17345	COG0739	heme binding
G4Y79_RS17355	COG3942	CHAP domain
G4Y79_RS17355	COG1388	LysM domain
G4Y79_RS17370	COG1027	Aspartate ammonia-lyase
G4Y79_RS17375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G4Y79_RS17380	COG0697	spore germination
G4Y79_RS17395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4Y79_RS17400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4Y79_RS17420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G4Y79_RS17425	COG0740	serine-type endopeptidase activity
G4Y79_RS17430	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4Y79_RS17450	COG0577	efflux transmembrane transporter activity
G4Y79_RS17450	COG1136	(ABC) transporter
G4Y79_RS17455	COG0577	efflux transmembrane transporter activity
G4Y79_RS17455	COG1136	(ABC) transporter
G4Y79_RS17460	COG0577	efflux transmembrane transporter activity
G4Y79_RS17460	COG1136	(ABC) transporter
G4Y79_RS17470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G4Y79_RS17475	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G4Y79_RS17490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4Y79_RS17495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G4Y79_RS17500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4Y79_RS17505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4Y79_RS17510	COG4948	Mandelate Racemase Muconate Lactonizing
G4Y79_RS17525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4Y79_RS17530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Y79_RS17540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G4Y79_RS17550	COG2068	MobA-Related Protein
G4Y79_RS17580	COG3608	succinylglutamate desuccinylase aspartoacylase
G4Y79_RS17580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G4Y79_RS17590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Y79_RS17595	COG1920	GTP binding
G4Y79_RS17600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4Y79_RS17605	COG0778	Nitroreductase
G4Y79_RS17605	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G4Y79_RS17610	COG0778	Nitroreductase
G4Y79_RS17610	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G4Y79_RS17620	COG0402	S-adenosylhomocysteine deaminase activity
G4Y79_RS17640	COG0463	Glycosyl transferase, family 2
G4Y79_RS17645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4Y79_RS17650	COG0537	adenosine 5'-monophosphoramidase activity
G4Y79_RS17655	COG0549	Belongs to the carbamate kinase family
G4Y79_RS17675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4Y79_RS17690	COG0346	lactoylglutathione lyase activity
G4Y79_RS17695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Y79_RS17700	COG0494	nUDIX hydrolase
G4Y79_RS17710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4Y79_RS17720	COG0194	GDP metabolic process
G4Y79_RS17725	COG0354	folic acid binding
G4Y79_RS17755	COG3833	ABC-type maltose transport systems, permease component
G4Y79_RS17760	COG1175	transmembrane transport
G4Y79_RS17775	COG4585	Histidine kinase
G4Y79_RS17795	COG5002	protein histidine kinase activity
G4Y79_RS17800	COG0083	homoserine kinase activity
G4Y79_RS17805	COG1132	(ABC) transporter
G4Y79_RS17810	COG2813	Specifically methylates the guanine in position
G4Y79_RS17815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4Y79_RS17820	COG2226	methyltransferase
G4Y79_RS17830	COG0717	Belongs to the dCTP deaminase family
G4Y79_RS17835	COG0328	RNA-DNA hybrid ribonuclease activity
G4Y79_RS17850	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS17885	COG5002	protein histidine kinase activity
G4Y79_RS17890	COG1940	carbohydrate kinase activity
G4Y79_RS17895	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G4Y79_RS17905	COG0596	Alpha beta hydrolase
G4Y79_RS17905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4Y79_RS17905	COG2226	methyltransferase
G4Y79_RS17910	COG3872	metal-dependent enzyme
G4Y79_RS17920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G4Y79_RS17920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4Y79_RS17925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4Y79_RS17935	COG1983	PspC domain protein
G4Y79_RS17940	COG1983	PspC domain protein
G4Y79_RS17950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G4Y79_RS17955	COG0039	L-malate dehydrogenase activity
G4Y79_RS17960	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G4Y79_RS17985	COG0196	riboflavin kinase activity
G4Y79_RS17990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G4Y79_RS17995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G4Y79_RS18000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G4Y79_RS18005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G4Y79_RS18010	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G4Y79_RS18015	COG0195	Participates in both transcription termination and antitermination
G4Y79_RS18055	COG2226	methyltransferase
G4Y79_RS18060	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS18070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G4Y79_RS18075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4Y79_RS18080	COG0516	GMP reductase activity
G4Y79_RS18080	COG0517	IMP dehydrogenase activity
G4Y79_RS18115	COG0183	Belongs to the thiolase family
G4Y79_RS18130	COG1132	(ABC) transporter
G4Y79_RS18135	COG1132	(ABC) transporter
G4Y79_RS18140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4Y79_RS18155	COG5002	protein histidine kinase activity
G4Y79_RS18195	COG1187	pseudouridine synthase activity
G4Y79_RS18210	COG0788	formyltetrahydrofolate deformylase activity
G4Y79_RS18215	COG2226	methyltransferase
G4Y79_RS18225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4Y79_RS18240	COG0542	response to heat
G4Y79_RS18245	COG1472	Belongs to the glycosyl hydrolase 3 family
G4Y79_RS18265	COG2204	response regulator
G4Y79_RS18275	COG1077	Cell shape determining protein MreB Mrl
G4Y79_RS18290	COG0768	penicillin binding
G4Y79_RS18300	COG0850	regulation of cytokinetic process
G4Y79_RS18305	COG2894	cell division
G4Y79_RS18310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G4Y79_RS18315	COG0772	Belongs to the SEDS family
G4Y79_RS18320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4Y79_RS18345	COG5002	protein histidine kinase activity
G4Y79_RS18350	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G4Y79_RS18355	COG0335	large ribosomal subunit rRNA binding
G4Y79_RS18365	COG3942	CHAP domain
G4Y79_RS18365	COG1388	LysM domain
G4Y79_RS18375	COG1968	undecaprenyl-diphosphatase activity
G4Y79_RS18380	COG2814	Major facilitator Superfamily
G4Y79_RS18395	COG0189	ligase activity
G4Y79_RS18400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G4Y79_RS18405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4Y79_RS18410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4Y79_RS18415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Y79_RS18420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4Y79_RS18425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4Y79_RS18430	COG0066	3-isopropylmalate dehydratase activity
G4Y79_RS18435	COG1653	transport
G4Y79_RS18440	COG1175	transmembrane transport
G4Y79_RS18445	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS18455	COG1486	melibiose metabolic process
G4Y79_RS18465	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS18470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Y79_RS18475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Y79_RS18485	COG1605	Chorismate mutase
G4Y79_RS18485	COG0077	Prephenate dehydratase
G4Y79_RS18495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G4Y79_RS18500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G4Y79_RS18680	COG3320	Male sterility
G4Y79_RS18680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4Y79_RS18685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4Y79_RS18745	COG1754	DNA topoisomerase type I activity
G4Y79_RS18745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Y79_RS18750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Y79_RS18755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4Y79_RS18785	COG0515	serine threonine protein kinase
G4Y79_RS18785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Y79_RS18860	COG2201	protein-glutamate methylesterase activity
G4Y79_RS18870	COG3685	Protein conserved in bacteria
G4Y79_RS18875	COG0109	protoheme IX farnesyltransferase activity
G4Y79_RS18880	COG3794	PFAM blue (type 1) copper domain protein
G4Y79_RS18910	COG1845	cytochrome c oxidase, subunit III
G4Y79_RS18910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4Y79_RS18920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4Y79_RS18920	COG2010	Cytochrome c
G4Y79_RS18965	COG1160	GTP binding
G4Y79_RS18985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4Y79_RS18990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Y79_RS18990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4Y79_RS19020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Y79_RS19045	COG1803	Methylglyoxal synthase
G4Y79_RS19070	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS19075	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS19080	COG5002	protein histidine kinase activity
G4Y79_RS19085	COG1543	Belongs to the glycosyl hydrolase 57 family
G4Y79_RS19090	COG0297	glycogen (starch) synthase activity
G4Y79_RS19095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4Y79_RS19115	COG1668	transmembrane transport
G4Y79_RS19120	COG4152	abc transporter atp-binding protein
G4Y79_RS19130	COG0741	lytic transglycosylase activity
G4Y79_RS19150	COG1331	Highly conserved protein containing a thioredoxin domain
G4Y79_RS19160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Y79_RS19165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4Y79_RS19170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G4Y79_RS19185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4Y79_RS19190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4Y79_RS19195	COG0509	glycine decarboxylation via glycine cleavage system
G4Y79_RS19205	COG1999	signal sequence binding
G4Y79_RS19210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4Y79_RS19215	COG0343	queuine tRNA-ribosyltransferase activity
G4Y79_RS19220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G4Y79_RS19230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4Y79_RS19245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4Y79_RS19265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4Y79_RS19280	COG0656	L-ascorbic acid biosynthetic process
G4Y79_RS19295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4Y79_RS19300	COG1120	ATPase activity
G4Y79_RS19305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4Y79_RS19310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4Y79_RS19325	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS19370	COG0346	lactoylglutathione lyase activity
G4Y79_RS19380	COG4221	oxidoreductase activity
G4Y79_RS19385	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
G4Y79_RS19395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4Y79_RS19400	COG2217	Heavy metal translocating P-type atpase
G4Y79_RS19435	COG0604	alcohol dehydrogenase
G4Y79_RS19460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4Y79_RS19465	COG0439	Biotin carboxylase
G4Y79_RS19470	COG5016	pyruvate
G4Y79_RS19470	COG0511	ligase activity, forming carbon-carbon bonds
G4Y79_RS19510	COG4221	oxidoreductase activity
G4Y79_RS19520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4Y79_RS19525	COG0205	6-phosphofructokinase activity
G4Y79_RS19535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4Y79_RS19575	COG0653	protein targeting
G4Y79_RS19585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4Y79_RS19595	COG5002	protein histidine kinase activity
G4Y79_RS19605	COG3118	belongs to the thioredoxin family
G4Y79_RS19610	COG1420	regulation of RNA biosynthetic process
G4Y79_RS19615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4Y79_RS19620	COG0443	Heat shock 70 kDa protein
G4Y79_RS19625	COG0484	heat shock protein binding
G4Y79_RS19630	COG2264	protein methyltransferase activity
G4Y79_RS19640	COG2226	methyltransferase
G4Y79_RS19645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G4Y79_RS19650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G4Y79_RS19655	COG0539	negative regulation of cytoplasmic translation
G4Y79_RS19665	COG0539	negative regulation of cytoplasmic translation
G4Y79_RS19670	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G4Y79_RS19690	COG0628	permease
G4Y79_RS19700	COG1185	polyribonucleotide nucleotidyltransferase activity
G4Y79_RS19715	COG0442	prolyl-tRNA aminoacylation
G4Y79_RS19725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4Y79_RS19735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4Y79_RS19740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4Y79_RS19750	COG0356	it plays a direct role in the translocation of protons across the membrane
G4Y79_RS19760	COG1007	ATP synthesis coupled electron transport
G4Y79_RS19765	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Y79_RS19775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4Y79_RS19790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G4Y79_RS19795	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4Y79_RS19810	COG0596	Alpha beta hydrolase
G4Y79_RS19820	COG0456	acetyltransferase
G4Y79_RS19830	COG2373	Large extracellular alpha-helical protein
G4Y79_RS19845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4Y79_RS19855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4Y79_RS19875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4Y79_RS19880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4Y79_RS19895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4Y79_RS19900	COG0772	Belongs to the SEDS family
G4Y79_RS19905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4Y79_RS19910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4Y79_RS19925	COG0275	rRNA processing
G4Y79_RS19930	COG2001	Belongs to the MraZ family
G4Y79_RS19945	COG0322	excinuclease ABC activity
G4Y79_RS19970	COG1388	LysM domain
G4Y79_RS19970	COG3584	3D domain protein
G4Y79_RS19975	COG0318	PFAM AMP-dependent synthetase and ligase
G4Y79_RS19980	COG1929	Belongs to the glycerate kinase type-1 family
G4Y79_RS19990	COG2202	Pas domain
G4Y79_RS19990	COG2205	protein histidine kinase activity
G4Y79_RS19995	COG2202	Pas domain
G4Y79_RS19995	COG2205	protein histidine kinase activity
G4Y79_RS20000	COG2205	protein histidine kinase activity
G4Y79_RS20000	COG3437	response regulator, receiver
G4Y79_RS20000	COG3850	Histidine kinase
G4Y79_RS20000	COG4999	Histidine kinase
G4Y79_RS20005	COG1597	lipid kinase activity
G4Y79_RS20010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4Y79_RS20015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G4Y79_RS20035	COG0667	Aldo Keto reductase
G4Y79_RS20065	COG0318	PFAM AMP-dependent synthetase and ligase
G4Y79_RS20085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4Y79_RS20135	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS20140	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS20145	COG1024	Enoyl-CoA hydratase
G4Y79_RS20145	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4Y79_RS20150	COG0183	Belongs to the thiolase family
G4Y79_RS20160	COG0346	lactoylglutathione lyase activity
G4Y79_RS20165	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
G4Y79_RS20175	COG0277	FAD linked oxidase domain protein
G4Y79_RS20195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4Y79_RS20210	COG3012	SEC-C Motif Domain Protein
G4Y79_RS20215	COG2966	Psort location CytoplasmicMembrane, score
G4Y79_RS20225	COG2124	cytochrome p450
G4Y79_RS20230	COG0366	Alpha amylase catalytic
G4Y79_RS20235	COG0716	FMN binding
G4Y79_RS20245	COG0124	histidyl-tRNA synthetase
G4Y79_RS20250	COG0535	radical SAM domain protein
G4Y79_RS20260	COG2181	nitrate reductase activity
G4Y79_RS20260	COG0247	lactate metabolic process
G4Y79_RS20265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4Y79_RS20270	COG0022	dehydrogenase e1 component
G4Y79_RS20275	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Y79_RS20310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Y79_RS20320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G4Y79_RS20325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G4Y79_RS20330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4Y79_RS20360	COG1609	Transcriptional regulator
G4Y79_RS20370	COG1175	transmembrane transport
G4Y79_RS20375	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS20385	COG4166	transmembrane transport
G4Y79_RS20390	COG0601	transmembrane transport
G4Y79_RS20395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS20395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4Y79_RS20400	COG1940	carbohydrate kinase activity
G4Y79_RS20405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
G4Y79_RS20425	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS20455	COG0463	Glycosyl transferase, family 2
G4Y79_RS20535	COG0823	Involved in the tonB-independent uptake of proteins
G4Y79_RS20640	COG1611	Belongs to the LOG family
G4Y79_RS20650	COG2261	transglycosylase associated protein
G4Y79_RS20675	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G4Y79_RS20680	COG0598	Magnesium transport protein CorA
G4Y79_RS20695	COG2010	Cytochrome c
G4Y79_RS20715	COG1138	Cytochrome C-type biogenesis protein
G4Y79_RS20725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4Y79_RS20745	COG1131	(ABC) transporter
G4Y79_RS20965	COG0455	bacterial-type flagellum organization
G4Y79_RS20970	COG5002	protein histidine kinase activity
G4Y79_RS20970	COG2176	DNA-directed DNA polymerase activity
G4Y79_RS21005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4Y79_RS21020	COG0789	Transcriptional regulator
G4Y79_RS21045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4Y79_RS21050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4Y79_RS21055	COG0072	phenylalanine-tRNA ligase activity
G4Y79_RS21065	COG1254	Belongs to the acylphosphatase family
G4Y79_RS21075	COG1024	Enoyl-CoA hydratase
G4Y79_RS21110	COG1234	tRNA 3'-trailer cleavage
G4Y79_RS21115	COG4122	O-methyltransferase activity
G4Y79_RS21125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4Y79_RS21135	COG0359	binds to the 23S rRNA
G4Y79_RS21155	COG0783	Belongs to the Dps family
G4Y79_RS21160	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS21165	COG1722	exodeoxyribonuclease VII activity
G4Y79_RS21170	COG1570	exodeoxyribonuclease VII activity
G4Y79_RS21185	COG1268	BioY protein
G4Y79_RS21190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G4Y79_RS21195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4Y79_RS21200	COG0300	oxidoreductase activity
G4Y79_RS21210	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G4Y79_RS21215	COG0003	Pfam Anion-transporting ATPase
G4Y79_RS21250	COG0702	epimerase
G4Y79_RS21255	COG0519	Catalyzes the synthesis of GMP from XMP
G4Y79_RS21270	COG1573	uracil-dna glycosylase
G4Y79_RS21280	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS21285	COG5002	protein histidine kinase activity
G4Y79_RS21295	COG0589	response to stress
G4Y79_RS21315	COG5002	protein histidine kinase activity
G4Y79_RS21320	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS21330	COG1132	(ABC) transporter
G4Y79_RS21335	COG5322	oxidoreductase activity
G4Y79_RS21345	COG0596	Alpha beta hydrolase
G4Y79_RS21375	COG0515	serine threonine protein kinase
G4Y79_RS21375	COG2815	serine threonine protein kinase
G4Y79_RS21415	COG2363	Small membrane protein
G4Y79_RS21445	COG0515	serine threonine protein kinase
G4Y79_RS21445	COG2815	serine threonine protein kinase
G4Y79_RS21450	COG0542	response to heat
G4Y79_RS21455	COG0515	serine threonine protein kinase
G4Y79_RS21455	COG2815	serine threonine protein kinase
G4Y79_RS21465	COG2267	carboxylic ester hydrolase activity
G4Y79_RS21470	COG0697	spore germination
G4Y79_RS21475	COG1051	belongs to the nudix hydrolase family
G4Y79_RS21505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G4Y79_RS21510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G4Y79_RS21515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4Y79_RS21520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4Y79_RS21595	COG0038	chloride channel
G4Y79_RS21600	COG1621	beta-fructofuranosidase activity
G4Y79_RS21630	COG1120	ATPase activity
G4Y79_RS21640	COG0501	Belongs to the peptidase M48B family
G4Y79_RS21645	COG0484	heat shock protein binding
G4Y79_RS21650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4Y79_RS21650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4Y79_RS21655	COG1162	GTPase activity
G4Y79_RS21660	COG2815	serine threonine protein kinase
G4Y79_RS21660	COG0515	serine threonine protein kinase
G4Y79_RS21670	COG0242	peptide deformylase activity
G4Y79_RS21680	COG4946	Tricorn protease homolog
G4Y79_RS21680	COG1506	peptidase
G4Y79_RS21680	COG0823	Involved in the tonB-independent uptake of proteins
G4Y79_RS21685	COG1957	nucleoside hydrolase
G4Y79_RS21700	COG0357	Ribosomal RNA small subunit methyltransferase G
G4Y79_RS21710	COG1253	flavin adenine dinucleotide binding
G4Y79_RS21725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4Y79_RS21735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4Y79_RS21765	COG5002	protein histidine kinase activity
G4Y79_RS21775	COG0542	response to heat
G4Y79_RS21785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Y79_RS21785	COG0515	serine threonine protein kinase
G4Y79_RS21795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4Y79_RS21820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4Y79_RS21840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4Y79_RS21850	COG0189	ligase activity
G4Y79_RS21850	COG0569	domain protein
G4Y79_RS21855	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS21900	COG3852	Histidine kinase
G4Y79_RS21905	COG2205	protein histidine kinase activity
G4Y79_RS21910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS21935	COG0222	ribosome binding
G4Y79_RS21940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G4Y79_RS21945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G4Y79_RS21970	COG1132	(ABC) transporter
G4Y79_RS21975	COG1132	(ABC) transporter
G4Y79_RS22005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4Y79_RS22030	COG0436	Aminotransferase
G4Y79_RS22075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4Y79_RS22115	COG0460	homoserine dehydrogenase
G4Y79_RS22155	COG2205	protein histidine kinase activity
G4Y79_RS22160	COG2223	nitrite transmembrane transporter activity
G4Y79_RS22165	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
G4Y79_RS22180	COG1175	transmembrane transport
G4Y79_RS22185	COG0395	ABC-type sugar transport system, permease component
G4Y79_RS22265	COG0765	amino acid transport
G4Y79_RS22275	COG1595	DNA-templated transcription, initiation
G4Y79_RS22285	COG0493	'glutamate synthase
G4Y79_RS22290	COG0006	proline dipeptidase activity
G4Y79_RS22310	COG2205	protein histidine kinase activity
G4Y79_RS22315	COG5002	protein histidine kinase activity
G4Y79_RS22325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4Y79_RS22330	COG2201	protein-glutamate methylesterase activity
G4Y79_RS22335	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS22350	COG2203	Gaf domain
G4Y79_RS22350	COG4585	Histidine kinase
G4Y79_RS22365	COG5002	protein histidine kinase activity
G4Y79_RS22365	COG0784	Response regulator, receiver
G4Y79_RS22370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4Y79_RS22375	COG2205	protein histidine kinase activity
G4Y79_RS22405	COG0708	Exodeoxyribonuclease III
G4Y79_RS22420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4Y79_RS22430	COG2388	GCN5-related N-acetyl-transferase
G4Y79_RS22445	COG2814	Major facilitator Superfamily
G4Y79_RS22470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4Y79_RS22470	COG3743	rRNA binding
G4Y79_RS22485	COG0542	response to heat
G4Y79_RS22490	COG0539	negative regulation of cytoplasmic translation
G4Y79_RS22495	COG0542	response to heat
G4Y79_RS22510	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS22525	COG3214	Protein conserved in bacteria
G4Y79_RS22530	COG2176	DNA-directed DNA polymerase activity
G4Y79_RS22530	COG5002	protein histidine kinase activity
G4Y79_RS22550	COG1408	metallophosphoesterase
G4Y79_RS22555	COG2318	DinB family
G4Y79_RS22565	COG0673	inositol 2-dehydrogenase activity
G4Y79_RS22575	COG0667	Aldo Keto reductase
G4Y79_RS22600	COG1028	Short-chain dehydrogenase reductase Sdr
G4Y79_RS22605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G4Y79_RS22615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Y79_RS22620	COG0484	heat shock protein binding
G4Y79_RS22625	COG1247	-acetyltransferase
G4Y79_RS22630	COG1363	Peptidase, m42
G4Y79_RS22655	COG0459	protein refolding
G4Y79_RS22660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G4Y79_RS22665	COG1569	PIN domain
G4Y79_RS22670	COG3311	Transcriptional regulator
G4Y79_RS22675	COG2815	serine threonine protein kinase
G4Y79_RS22675	COG0515	serine threonine protein kinase
G4Y79_RS22735	COG0187	DNA topoisomerase II activity
G4Y79_RS22780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4Y79_RS22790	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G4Y79_RS22800	COG0697	spore germination
G4Y79_RS22805	COG1522	sequence-specific DNA binding
G4Y79_RS22835	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Y79_RS22840	COG0022	dehydrogenase e1 component
G4Y79_RS22840	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4Y79_RS22845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G4Y79_RS22860	COG2814	Major facilitator Superfamily
G4Y79_RS22890	COG0495	leucyl-tRNA aminoacylation
G4Y79_RS22910	COG0511	ligase activity, forming carbon-carbon bonds
G4Y79_RS22910	COG5016	pyruvate
G4Y79_RS22920	COG0439	Biotin carboxylase
G4Y79_RS22925	COG1316	TRANSCRIPTIONal
G4Y79_RS22950	COG1047	Peptidyl-prolyl cis-trans
G4Y79_RS22955	COG0424	maF-like protein
G4Y79_RS22985	COG1525	nuclease
G4Y79_RS23000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4Y79_RS23005	COG4597	amino acid ABC transporter
G4Y79_RS23010	COG0765	amino acid transport
G4Y79_RS23015	COG1126	abc transporter atp-binding protein
G4Y79_RS23035	COG1482	cell wall glycoprotein biosynthetic process
G4Y79_RS23070	COG0473	3-isopropylmalate dehydrogenase activity
G4Y79_RS23100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G4Y79_RS23105	COG0488	(ABC) transporter
G4Y79_RS23150	COG5002	protein histidine kinase activity
G4Y79_RS23195	COG0728	peptidoglycan biosynthetic process
G4Y79_RS23200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4Y79_RS23200	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G4Y79_RS23205	COG0483	inositol monophosphate 1-phosphatase activity
G4Y79_RS23215	COG1309	transcriptional regulator
G4Y79_RS23230	COG0523	cobalamin synthesis protein
G4Y79_RS23255	COG0701	Predicted permease
G4Y79_RS23270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4Y79_RS23280	COG1546	Belongs to the CinA family
G4Y79_RS23280	COG1058	Belongs to the CinA family
G4Y79_RS23295	COG2272	Belongs to the type-B carboxylesterase lipase family
G4Y79_RS23300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4Y79_RS23310	COG0668	transmembrane transport
G4Y79_RS23345	COG0667	Aldo Keto reductase
G4Y79_RS23350	COG3616	Alanine racemase, N-terminal domain
G4Y79_RS23360	COG2205	protein histidine kinase activity
G4Y79_RS23360	COG5002	protein histidine kinase activity
G4Y79_RS23360	COG0784	Response regulator, receiver
G4Y79_RS23385	COG0406	alpha-ribazole phosphatase activity
G4Y79_RS23410	COG1193	negative regulation of DNA recombination
G4Y79_RS23420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4Y79_RS23425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G4Y79_RS23435	COG2301	Belongs to the HpcH HpaI aldolase family
G4Y79_RS23460	COG0668	transmembrane transport
G4Y79_RS23465	COG0668	transmembrane transport
G4Y79_RS23520	COG1063	alcohol dehydrogenase
G4Y79_RS23535	COG0367	asparagine synthase
G4Y79_RS23540	COG2814	Major facilitator Superfamily
G4Y79_RS23555	COG0758	DNA mediated transformation
G4Y79_RS23565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4Y79_RS23600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4Y79_RS23640	COG3118	belongs to the thioredoxin family
G4Y79_RS23650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4Y79_RS23655	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G4Y79_RS23660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4Y79_RS23670	COG2226	methyltransferase
G4Y79_RS23690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4Y79_RS23720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G4Y79_RS23725	COG0045	succinate-CoA ligase (ADP-forming) activity
G4Y79_RS23745	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G4Y79_RS23750	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G4Y79_RS23750	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G4Y79_RS23785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4Y79_RS23795	COG2226	methyltransferase
G4Y79_RS23820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4Y79_RS23825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G4Y79_RS23845	COG1764	response to oxidative stress
G4Y79_RS23860	COG0366	Alpha amylase catalytic
G4Y79_RS23875	COG0251	oxidation-reduction process
G4Y79_RS23905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G4Y79_RS23920	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS23950	COG0134	indole-3-glycerol-phosphate synthase activity
G4Y79_RS23955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4Y79_RS23960	COG0745	RESPONSE REGULATOR receiver
G4Y79_RS23985	COG0519	Catalyzes the synthesis of GMP from XMP
G4Y79_RS23985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4Y79_RS24000	COG1309	transcriptional regulator
G4Y79_RS24005	COG0438	transferase activity, transferring glycosyl groups
G4Y79_RS24040	COG1164	Oligoendopeptidase f
G4Y79_RS24055	COG1136	(ABC) transporter
G4Y79_RS24055	COG0577	efflux transmembrane transporter activity
G4Y79_RS24075	COG0584	glycerophosphoryl diester phosphodiesterase
G4Y79_RS24105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G4Y79_RS24120	COG1410	methionine synthase
G4Y79_RS24120	COG0646	methionine synthase
G4Y79_RS24140	COG0656	L-ascorbic acid biosynthetic process
G4Y79_RS24160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4Y79_RS24165	COG2202	Pas domain
G4Y79_RS24165	COG2205	protein histidine kinase activity
G4Y79_RS24175	COG0768	penicillin binding
G4Y79_RS24220	COG0494	nUDIX hydrolase
G4Y79_RS24230	COG0129	dihydroxy-acid dehydratase activity
G4Y79_RS24260	COG0778	Nitroreductase
G4Y79_RS24260	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G4Y79_RS24285	COG1960	acyl-CoA dehydrogenase activity
G4Y79_RS24310	COG0574	Belongs to the PEP-utilizing enzyme family
G4Y79_RS24310	COG3848	Pyruvate phosphate dikinase
G4Y79_RS24315	COG0488	(ABC) transporter
G4Y79_RS24325	COG2323	membrane
G4Y79_RS24350	COG5183	chlorophyll binding
G4Y79_RS24350	COG2133	pyrroloquinoline quinone binding
G4Y79_RS24360	COG0671	phosphoesterase, PA-phosphatase related
G4Y79_RS24390	COG4585	Histidine kinase
G4Y79_RS24395	COG1051	belongs to the nudix hydrolase family
G4Y79_RS24410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4Y79_RS24420	COG0640	Transcriptional regulator
G4Y79_RS24425	COG1830	Aldolase