locus-tag	class	description
A2CP1_RS00030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A2CP1_RS00050	COG0247	lactate metabolic process
A2CP1_RS00050	COG2181	nitrate reductase activity
A2CP1_RS00065	COG0189	ligase activity
A2CP1_RS00070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A2CP1_RS00075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A2CP1_RS00080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A2CP1_RS00105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A2CP1_RS00150	COG3436	PFAM IS66 Orf2 family protein
A2CP1_RS00195	COG3852	Histidine kinase
A2CP1_RS00205	COG0442	prolyl-tRNA aminoacylation
A2CP1_RS00235	COG0840	transmembrane signaling receptor activity
A2CP1_RS00245	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS00260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2CP1_RS00270	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A2CP1_RS00280	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A2CP1_RS00295	COG0280	phosphate acetyltransferase
A2CP1_RS00300	COG3426	butyrate kinase activity
A2CP1_RS00330	COG2086	electron transfer activity
A2CP1_RS00340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2CP1_RS00345	COG0861	Integral membrane protein TerC family
A2CP1_RS00365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A2CP1_RS00365	COG1793	dna ligase
A2CP1_RS00370	COG0564	pseudouridine synthase activity
A2CP1_RS00390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2CP1_RS00395	COG0805	protein transport
A2CP1_RS00405	COG0183	Belongs to the thiolase family
A2CP1_RS00425	COG1032	radical SAM domain protein
A2CP1_RS00440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A2CP1_RS00470	COG0352	thiamine-phosphate diphosphorylase activity
A2CP1_RS00475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A2CP1_RS00480	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A2CP1_RS00480	COG0351	phosphomethylpyrimidine kinase
A2CP1_RS00480	COG0352	thiamine-phosphate diphosphorylase activity
A2CP1_RS00490	COG0305	Participates in initiation and elongation during chromosome replication
A2CP1_RS00500	COG1346	cytolysis
A2CP1_RS00510	COG0583	DNA-binding transcription factor activity
A2CP1_RS00515	COG1410	methionine synthase
A2CP1_RS00515	COG0646	methionine synthase
A2CP1_RS00540	COG0433	COG0433 Predicted ATPase
A2CP1_RS00585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A2CP1_RS00590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A2CP1_RS00605	COG0612	Peptidase, M16
A2CP1_RS00610	COG0612	Peptidase, M16
A2CP1_RS00625	COG2204	response regulator
A2CP1_RS00630	COG3852	Histidine kinase
A2CP1_RS00655	COG1077	Cell shape determining protein MreB Mrl
A2CP1_RS00660	COG1077	Cell shape determining protein MreB Mrl
A2CP1_RS00665	COG1506	peptidase
A2CP1_RS00665	COG0823	Involved in the tonB-independent uptake of proteins
A2CP1_RS00685	COG0360	Binds together with S18 to 16S ribosomal RNA
A2CP1_RS00700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A2CP1_RS00725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A2CP1_RS00730	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A2CP1_RS00755	COG3706	GGDEF domain
A2CP1_RS00790	COG2022	thiamine diphosphate biosynthetic process
A2CP1_RS00790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A2CP1_RS00800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A2CP1_RS00815	COG2204	response regulator
A2CP1_RS00825	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A2CP1_RS00835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2CP1_RS00835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2CP1_RS00850	COG3716	PTS system mannose fructose sorbose family IID component
A2CP1_RS00855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2CP1_RS00875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A2CP1_RS00890	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A2CP1_RS00890	COG0662	Cupin 2, conserved barrel domain protein
A2CP1_RS00900	COG1940	carbohydrate kinase activity
A2CP1_RS00900	COG1846	Transcriptional regulator
A2CP1_RS00905	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A2CP1_RS00950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A2CP1_RS00990	COG3138	arginine N-succinyltransferase
A2CP1_RS00995	COG1490	D-aminoacyl-tRNA deacylase activity
A2CP1_RS01000	COG0537	adenosine 5'-monophosphoramidase activity
A2CP1_RS01040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A2CP1_RS01050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A2CP1_RS01085	COG0564	pseudouridine synthase activity
A2CP1_RS01110	COG1612	heme a metabolic process
A2CP1_RS01110	COG0109	protoheme IX farnesyltransferase activity
A2CP1_RS01140	COG2814	Major facilitator Superfamily
A2CP1_RS01165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A2CP1_RS01180	COG2226	methyltransferase
A2CP1_RS01185	COG0697	spore germination
A2CP1_RS01195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2CP1_RS01195	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2CP1_RS01195	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2CP1_RS01240	COG1309	transcriptional regulator
A2CP1_RS01275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A2CP1_RS01300	COG3070	regulator of competence-specific genes
A2CP1_RS01305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A2CP1_RS01315	COG1297	OPT oligopeptide transporter protein
A2CP1_RS01320	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS01325	COG2264	protein methyltransferase activity
A2CP1_RS01330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A2CP1_RS01345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A2CP1_RS01355	COG1278	Cold shock
A2CP1_RS01370	COG0204	Acyl-transferase
A2CP1_RS01380	COG5002	protein histidine kinase activity
A2CP1_RS01385	COG4770	biotin carboxylase activity
A2CP1_RS01390	COG0511	ligase activity, forming carbon-carbon bonds
A2CP1_RS01390	COG5016	pyruvate
A2CP1_RS01395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A2CP1_RS01395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A2CP1_RS01400	COG0484	heat shock protein binding
A2CP1_RS01425	COG0564	pseudouridine synthase activity
A2CP1_RS01430	COG0848	biopolymer transport protein
A2CP1_RS01440	COG0811	peptide transport
A2CP1_RS01480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2CP1_RS01480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A2CP1_RS01485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A2CP1_RS01490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A2CP1_RS01495	COG0617	tRNA 3'-terminal CCA addition
A2CP1_RS01500	COG0528	UMP kinase activity
A2CP1_RS01525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A2CP1_RS01525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A2CP1_RS01555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2CP1_RS01560	COG2062	phosphohistidine phosphatase, SixA
A2CP1_RS01570	COG1640	4-alpha-glucanotransferase
A2CP1_RS01575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A2CP1_RS01595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A2CP1_RS01605	COG3852	Histidine kinase
A2CP1_RS01615	COG2839	Protein conserved in bacteria
A2CP1_RS01650	COG1942	4-Oxalocrotonate Tautomerase
A2CP1_RS01655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A2CP1_RS01660	COG0583	DNA-binding transcription factor activity
A2CP1_RS01725	COG0308	aminopeptidase N
A2CP1_RS01730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2CP1_RS01745	COG2151	metal-sulfur cluster biosynthetic enzyme
A2CP1_RS01765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2CP1_RS01790	COG4206	TonB-dependent receptor
A2CP1_RS01810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2CP1_RS01820	COG0840	transmembrane signaling receptor activity
A2CP1_RS01865	COG2855	membrane
A2CP1_RS01870	COG0583	DNA-binding transcription factor activity
A2CP1_RS01890	COG1595	DNA-templated transcription, initiation
A2CP1_RS01920	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2CP1_RS01920	COG1024	Enoyl-CoA hydratase
A2CP1_RS01925	COG0183	Belongs to the thiolase family
A2CP1_RS01930	COG1960	acyl-CoA dehydrogenase activity
A2CP1_RS01955	COG2890	protein-(glutamine-N5) methyltransferase activity
A2CP1_RS01975	COG0402	S-adenosylhomocysteine deaminase activity
A2CP1_RS01980	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A2CP1_RS01985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A2CP1_RS01990	COG0163	prenyltransferase activity
A2CP1_RS01995	COG2226	methyltransferase
A2CP1_RS02000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A2CP1_RS02010	COG0612	Peptidase, M16
A2CP1_RS02050	COG0542	response to heat
A2CP1_RS02055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2CP1_RS02070	COG0318	PFAM AMP-dependent synthetase and ligase
A2CP1_RS02075	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A2CP1_RS02075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A2CP1_RS02130	COG1234	tRNA 3'-trailer cleavage
A2CP1_RS02135	COG1741	Belongs to the pirin family
A2CP1_RS02145	COG1131	(ABC) transporter
A2CP1_RS02160	COG0183	Belongs to the thiolase family
A2CP1_RS02165	COG1024	Enoyl-CoA hydratase
A2CP1_RS02165	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2CP1_RS02175	COG5002	protein histidine kinase activity
A2CP1_RS02180	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS02185	COG1921	L-seryl-tRNASec selenium transferase activity
A2CP1_RS02190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2CP1_RS02215	COG3852	Histidine kinase
A2CP1_RS02225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2CP1_RS02230	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A2CP1_RS02240	COG1088	dTDP-glucose 4,6-dehydratase activity
A2CP1_RS02245	COG0204	Acyl-transferase
A2CP1_RS02255	COG1846	Transcriptional regulator
A2CP1_RS02270	COG3706	GGDEF domain
A2CP1_RS02295	COG0420	3'-5' exonuclease activity
A2CP1_RS02330	COG1136	(ABC) transporter
A2CP1_RS02330	COG0577	efflux transmembrane transporter activity
A2CP1_RS02365	COG1309	transcriptional regulator
A2CP1_RS02375	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A2CP1_RS02385	COG0667	Aldo Keto reductase
A2CP1_RS02405	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A2CP1_RS02405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A2CP1_RS02410	COG3639	organic phosphonate transmembrane transporter activity
A2CP1_RS02415	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A2CP1_RS02470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A2CP1_RS02475	COG3875	lactate racemase activity
A2CP1_RS02505	COG0298	carbon dioxide binding
A2CP1_RS02510	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A2CP1_RS02520	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A2CP1_RS02525	COG5557	Pfam Polysulphide reductase, NrfD
A2CP1_RS02530	COG0437	4 iron, 4 sulfur cluster binding
A2CP1_RS02535	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A2CP1_RS02565	COG1285	pathogenesis
A2CP1_RS02570	COG2119	membrane
A2CP1_RS02595	COG1122	ATPase activity
A2CP1_RS02605	COG0310	cobalt ion transport
A2CP1_RS02620	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2CP1_RS02620	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A2CP1_RS02645	COG2205	protein histidine kinase activity
A2CP1_RS02660	COG5002	protein histidine kinase activity
A2CP1_RS02665	COG0493	'glutamate synthase
A2CP1_RS02665	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A2CP1_RS02670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2CP1_RS02670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2CP1_RS02675	COG2133	pyrroloquinoline quinone binding
A2CP1_RS02680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A2CP1_RS02725	COG1309	transcriptional regulator
A2CP1_RS02730	COG0366	Alpha amylase catalytic
A2CP1_RS02740	COG0596	Alpha beta hydrolase
A2CP1_RS02750	COG2832	Protein of unknown function (DUF454)
A2CP1_RS02780	COG0671	phosphoesterase, PA-phosphatase related
A2CP1_RS02785	COG1752	Esterase of the alpha-beta hydrolase superfamily
A2CP1_RS02795	COG0436	Aminotransferase
A2CP1_RS02805	COG3047	cAMP biosynthetic process
A2CP1_RS02810	COG4191	Histidine kinase
A2CP1_RS02820	COG1122	ATPase activity
A2CP1_RS02825	COG1268	BioY protein
A2CP1_RS02830	COG0400	carboxylic ester hydrolase activity
A2CP1_RS02870	COG0596	Alpha beta hydrolase
A2CP1_RS02875	COG0583	DNA-binding transcription factor activity
A2CP1_RS02885	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS02940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A2CP1_RS02945	COG3177	Filamentation induced by cAMP protein fic
A2CP1_RS02960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A2CP1_RS02970	COG1228	amidohydrolase
A2CP1_RS02975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A2CP1_RS02980	COG2204	response regulator
A2CP1_RS03005	COG0612	Peptidase, M16
A2CP1_RS03010	COG5002	protein histidine kinase activity
A2CP1_RS03040	COG2084	Dehydrogenase
A2CP1_RS03060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A2CP1_RS03065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A2CP1_RS03080	COG4232	protein-disulfide reductase activity
A2CP1_RS03095	COG0316	Belongs to the HesB IscA family
A2CP1_RS03100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A2CP1_RS03105	COG0443	Heat shock 70 kDa protein
A2CP1_RS03120	COG2201	protein-glutamate methylesterase activity
A2CP1_RS03130	COG0835	chemotaxis
A2CP1_RS03135	COG2198	Histidine kinase
A2CP1_RS03135	COG0643	Histidine kinase
A2CP1_RS03140	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A2CP1_RS03150	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS03165	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS03190	COG2201	protein-glutamate methylesterase activity
A2CP1_RS03200	COG0784	Response regulator, receiver
A2CP1_RS03210	COG0275	rRNA processing
A2CP1_RS03225	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS03245	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A2CP1_RS03250	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A2CP1_RS03260	COG0295	cytidine deaminase activity
A2CP1_RS03265	COG0196	riboflavin kinase activity
A2CP1_RS03270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2CP1_RS03280	COG1459	type II secretion system
A2CP1_RS03285	COG3852	Histidine kinase
A2CP1_RS03335	COG4968	Prepilin-type N-terminal cleavage methylation domain
A2CP1_RS03340	COG1131	(ABC) transporter
A2CP1_RS03345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A2CP1_RS03355	COG2204	response regulator
A2CP1_RS03400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A2CP1_RS03405	COG0511	ligase activity, forming carbon-carbon bonds
A2CP1_RS03410	COG0439	Biotin carboxylase
A2CP1_RS03420	COG3267	Type II secretory pathway component ExeA
A2CP1_RS03420	COG3409	Peptidoglycan-binding domain 1 protein
A2CP1_RS03435	COG2217	Heavy metal translocating P-type atpase
A2CP1_RS03480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A2CP1_RS03490	COG2884	Cell division ATP-binding protein ftsE
A2CP1_RS03495	COG2177	Part of the ABC transporter FtsEX involved in
A2CP1_RS03500	COG4942	peptidase
A2CP1_RS03505	COG0793	Belongs to the peptidase S41A family
A2CP1_RS03510	COG1215	transferase activity, transferring glycosyl groups
A2CP1_RS03520	COG0546	phosphoglycolate phosphatase activity
A2CP1_RS03525	COG0552	protein localization to endoplasmic reticulum
A2CP1_RS03530	COG1196	nuclear chromosome segregation
A2CP1_RS03535	COG0840	transmembrane signaling receptor activity
A2CP1_RS03535	COG3290	protein histidine kinase activity
A2CP1_RS03570	COG2165	general secretion pathway protein
A2CP1_RS03580	COG1459	type II secretion system
A2CP1_RS03585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2CP1_RS03590	COG1450	Type ii and iii secretion system protein
A2CP1_RS03610	COG0254	rRNA binding
A2CP1_RS03615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A2CP1_RS03635	COG1254	Belongs to the acylphosphatase family
A2CP1_RS03645	COG1530	ribonuclease E activity
A2CP1_RS03645	COG1530	ribonuclease E activity
A2CP1_RS03650	COG1295	ribonuclease BN
A2CP1_RS03655	COG0776	regulation of translation
A2CP1_RS03660	COG4789	Type iii secretion
A2CP1_RS03675	COG4794	Type iii secretion
A2CP1_RS03690	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A2CP1_RS03725	COG2197	response regulator
A2CP1_RS03730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A2CP1_RS03740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A2CP1_RS03750	COG0107	imidazoleglycerol-phosphate synthase activity
A2CP1_RS03795	COG1584	GPR1 FUN34 yaaH family protein
A2CP1_RS03800	COG0242	peptide deformylase activity
A2CP1_RS03810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A2CP1_RS03825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A2CP1_RS03830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A2CP1_RS03835	COG0497	DNA recombination
A2CP1_RS03840	COG0631	protein serine/threonine phosphatase activity
A2CP1_RS03845	COG0739	heme binding
A2CP1_RS03855	COG0653	protein targeting
A2CP1_RS03880	COG1203	CRISPR-associated helicase, Cas3
A2CP1_RS03910	COG1518	maintenance of DNA repeat elements
A2CP1_RS03940	COG1595	DNA-templated transcription, initiation
A2CP1_RS03965	COG0628	permease
A2CP1_RS03980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A2CP1_RS03990	COG0739	heme binding
A2CP1_RS04010	COG1881	PFAM PEBP family protein
A2CP1_RS04025	COG0348	domain, Protein
A2CP1_RS04035	COG0589	response to stress
A2CP1_RS04040	COG0167	dihydroorotate dehydrogenase activity
A2CP1_RS04060	COG0247	lactate metabolic process
A2CP1_RS04110	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS04120	COG1253	flavin adenine dinucleotide binding
A2CP1_RS04130	COG2264	protein methyltransferase activity
A2CP1_RS04140	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2CP1_RS04165	COG1643	Atp-dependent helicase
A2CP1_RS04180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A2CP1_RS04200	COG1595	DNA-templated transcription, initiation
A2CP1_RS04210	COG0437	4 iron, 4 sulfur cluster binding
A2CP1_RS04245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A2CP1_RS04270	COG0028	Belongs to the TPP enzyme family
A2CP1_RS04275	COG4948	Mandelate Racemase Muconate Lactonizing
A2CP1_RS04280	COG0247	lactate metabolic process
A2CP1_RS04280	COG0277	FAD linked oxidase domain protein
A2CP1_RS04285	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A2CP1_RS04295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2CP1_RS04310	COG1793	dna ligase
A2CP1_RS04315	COG0070	glutamate synthase
A2CP1_RS04315	COG0067	glutamate synthase
A2CP1_RS04315	COG0069	glutamate synthase activity
A2CP1_RS04320	COG0493	'glutamate synthase
A2CP1_RS04335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2CP1_RS04345	COG0437	4 iron, 4 sulfur cluster binding
A2CP1_RS04350	COG0243	molybdopterin cofactor binding
A2CP1_RS04350	COG3383	formate dehydrogenase (NAD+) activity
A2CP1_RS04355	COG0243	molybdopterin cofactor binding
A2CP1_RS04365	COG3973	AAA domain
A2CP1_RS04370	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A2CP1_RS04375	COG0488	(ABC) transporter
A2CP1_RS04380	COG1012	belongs to the aldehyde dehydrogenase family
A2CP1_RS04390	COG2204	response regulator
A2CP1_RS04395	COG4191	Histidine kinase
A2CP1_RS04400	COG1131	(ABC) transporter
A2CP1_RS04405	COG0842	Transport permease protein
A2CP1_RS04415	COG0514	ATP-dependent DNA helicase (RecQ)
A2CP1_RS04430	COG4681	YaeQ
A2CP1_RS04440	COG0719	Fe-S assembly protein
A2CP1_RS04445	COG0396	ATPase activity
A2CP1_RS04450	COG0719	Fe-S assembly protein
A2CP1_RS04455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A2CP1_RS04480	COG0793	Belongs to the peptidase S41A family
A2CP1_RS04490	COG0577	efflux transmembrane transporter activity
A2CP1_RS04490	COG1136	(ABC) transporter
A2CP1_RS04495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2CP1_RS04505	COG2197	response regulator
A2CP1_RS04520	COG0023	Translation Initiation Factor
A2CP1_RS04540	COG0058	SHG alpha-glucan phosphorylase activity
A2CP1_RS04550	COG1704	LemA family
A2CP1_RS04575	COG1396	sequence-specific DNA binding
A2CP1_RS04580	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS04605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A2CP1_RS04660	COG0668	transmembrane transport
A2CP1_RS04685	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS04690	COG2205	protein histidine kinase activity
A2CP1_RS04700	COG0531	amino acid
A2CP1_RS04720	COG2322	membrane
A2CP1_RS04735	COG0109	protoheme IX farnesyltransferase activity
A2CP1_RS04750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A2CP1_RS04770	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A2CP1_RS04780	COG0243	molybdopterin cofactor binding
A2CP1_RS04790	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A2CP1_RS04800	COG2132	Multicopper oxidase
A2CP1_RS04860	COG4191	Histidine kinase
A2CP1_RS04880	COG2873	o-acetylhomoserine
A2CP1_RS04895	COG0432	Pfam Uncharacterised protein family UPF0047
A2CP1_RS04900	COG0003	Pfam Anion-transporting ATPase
A2CP1_RS04915	COG1192	Involved in chromosome partitioning
A2CP1_RS04930	COG3384	dioxygenase
A2CP1_RS04935	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
A2CP1_RS04950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2CP1_RS04955	COG0584	glycerophosphoryl diester phosphodiesterase
A2CP1_RS04965	COG1271	oxidase subunit
A2CP1_RS04970	COG1294	oxidase, subunit
A2CP1_RS04985	COG1331	Highly conserved protein containing a thioredoxin domain
A2CP1_RS05020	COG2814	Major facilitator Superfamily
A2CP1_RS05045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A2CP1_RS05080	COG3285	dna ligase
A2CP1_RS05080	COG1793	dna ligase
A2CP1_RS05095	COG0427	acetyl-CoA hydrolase
A2CP1_RS05105	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS05115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A2CP1_RS05150	COG2814	Major facilitator Superfamily
A2CP1_RS05185	COG0010	Belongs to the arginase family
A2CP1_RS05195	COG2205	protein histidine kinase activity
A2CP1_RS05205	COG4783	chaperone-mediated protein folding
A2CP1_RS05220	COG1278	Cold shock
A2CP1_RS05235	COG1720	tRNA m6t6A37 methyltransferase activity
A2CP1_RS05275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A2CP1_RS05305	COG4603	Belongs to the binding-protein-dependent transport system permease family
A2CP1_RS05310	COG1129	ABC transporter
A2CP1_RS05315	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A2CP1_RS05335	COG0667	Aldo Keto reductase
A2CP1_RS05365	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS05370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A2CP1_RS05400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2CP1_RS05405	COG0798	PFAM Bile acid sodium symporter
A2CP1_RS05435	COG2226	methyltransferase
A2CP1_RS05595	COG0714	Associated with various cellular activities
A2CP1_RS05605	COG2003	Belongs to the UPF0758 family
A2CP1_RS05610	COG1475	DNA binding
A2CP1_RS05705	COG3504	Conjugal transfer protein
A2CP1_RS05790	COG1201	RNA secondary structure unwinding
A2CP1_RS05825	COG1335	isochorismatase
A2CP1_RS05830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A2CP1_RS05845	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A2CP1_RS05855	COG1692	metallophosphoesterase
A2CP1_RS05870	COG1104	cysteine desulfurase activity
A2CP1_RS05880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A2CP1_RS05900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A2CP1_RS05910	COG2204	response regulator
A2CP1_RS05940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2CP1_RS05950	COG0673	inositol 2-dehydrogenase activity
A2CP1_RS05955	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS05970	COG1132	(ABC) transporter
A2CP1_RS05980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2CP1_RS05990	COG5000	phosphorelay sensor kinase activity
A2CP1_RS06015	COG1543	Belongs to the glycosyl hydrolase 57 family
A2CP1_RS06035	COG1136	(ABC) transporter
A2CP1_RS06040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A2CP1_RS06065	COG3494	Protein of unknown function (DUF1009)
A2CP1_RS06075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A2CP1_RS06080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A2CP1_RS06085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A2CP1_RS06090	COG0484	heat shock protein binding
A2CP1_RS06100	COG1570	exodeoxyribonuclease VII activity
A2CP1_RS06105	COG1722	exodeoxyribonuclease VII activity
A2CP1_RS06110	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS06115	COG0142	geranyltranstransferase activity
A2CP1_RS06125	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A2CP1_RS06160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A2CP1_RS06180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A2CP1_RS06190	COG5002	protein histidine kinase activity
A2CP1_RS06210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2CP1_RS06220	COG0546	phosphoglycolate phosphatase activity
A2CP1_RS06230	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS06240	COG0750	zinc metalloprotease
A2CP1_RS06245	COG2078	PFAM AMMECR1 domain protein
A2CP1_RS06250	COG2816	NAD+ diphosphatase activity
A2CP1_RS06295	COG5002	protein histidine kinase activity
A2CP1_RS06305	COG1960	acyl-CoA dehydrogenase activity
A2CP1_RS06310	COG1324	tolerance protein
A2CP1_RS06320	COG0515	serine threonine protein kinase
A2CP1_RS06330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A2CP1_RS06335	COG0616	signal peptide processing
A2CP1_RS06340	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A2CP1_RS06345	COG1607	acyl-coa hydrolase
A2CP1_RS06365	COG1408	metallophosphoesterase
A2CP1_RS06390	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A2CP1_RS06395	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A2CP1_RS06420	COG1100	Small GTP-binding protein
A2CP1_RS06430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A2CP1_RS06450	COG4974	Belongs to the 'phage' integrase family
A2CP1_RS06510	COG1802	Transcriptional regulator
A2CP1_RS06510	COG4626	Terminase
A2CP1_RS06610	COG2226	methyltransferase
A2CP1_RS06615	COG0840	transmembrane signaling receptor activity
A2CP1_RS06620	COG1064	alcohol dehydrogenase
A2CP1_RS06635	COG0318	PFAM AMP-dependent synthetase and ligase
A2CP1_RS06640	COG3875	lactate racemase activity
A2CP1_RS06660	COG0243	molybdopterin cofactor binding
A2CP1_RS06665	COG3278	Belongs to the heme-copper respiratory oxidase family
A2CP1_RS06680	COG0348	domain, Protein
A2CP1_RS06705	COG1049	propionate catabolic process, 2-methylcitrate cycle
A2CP1_RS06755	COG0114	fumarate hydratase activity
A2CP1_RS06785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A2CP1_RS06810	COG1355	regulation of microtubule-based process
A2CP1_RS06830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A2CP1_RS06840	COG0443	Heat shock 70 kDa protein
A2CP1_RS06845	COG0484	heat shock protein binding
A2CP1_RS06855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A2CP1_RS06860	COG0010	Belongs to the arginase family
A2CP1_RS06865	COG1959	2 iron, 2 sulfur cluster binding
A2CP1_RS06870	COG0613	PHP domain protein
A2CP1_RS06875	COG1007	ATP synthesis coupled electron transport
A2CP1_RS06890	COG0713	ATP synthesis coupled electron transport
A2CP1_RS06900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2CP1_RS06905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A2CP1_RS06915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2CP1_RS06925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2CP1_RS06940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2CP1_RS06955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A2CP1_RS06960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2CP1_RS06975	COG2223	nitrite transmembrane transporter activity
A2CP1_RS06980	COG1796	DNA polymerase
A2CP1_RS06980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A2CP1_RS06990	COG0521	Mo-molybdopterin cofactor biosynthetic process
A2CP1_RS07025	COG0011	TIGRFAM Protein of
A2CP1_RS07050	COG1509	lysine 2,3-aminomutase activity
A2CP1_RS07055	COG0586	Pfam SNARE associated Golgi protein
A2CP1_RS07060	COG2385	sporulation resulting in formation of a cellular spore
A2CP1_RS07075	COG0343	queuine tRNA-ribosyltransferase activity
A2CP1_RS07080	COG1862	Preprotein translocase
A2CP1_RS07085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2CP1_RS07090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2CP1_RS07110	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A2CP1_RS07110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A2CP1_RS07115	COG0604	alcohol dehydrogenase
A2CP1_RS07130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A2CP1_RS07155	COG1597	lipid kinase activity
A2CP1_RS07165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A2CP1_RS07170	COG0612	Peptidase, M16
A2CP1_RS07185	COG0783	Belongs to the Dps family
A2CP1_RS07205	COG0352	thiamine-phosphate diphosphorylase activity
A2CP1_RS07220	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A2CP1_RS07225	COG1074	ATP-dependent DNA helicase activity
A2CP1_RS07240	COG1830	Aldolase
A2CP1_RS07280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A2CP1_RS07290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2CP1_RS07305	COG0768	penicillin binding
A2CP1_RS07310	COG0772	Belongs to the SEDS family
A2CP1_RS07315	COG3118	belongs to the thioredoxin family
A2CP1_RS07330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A2CP1_RS07335	COG0181	hydroxymethylbilane synthase activity
A2CP1_RS07350	COG0585	pseudouridine synthase activity
A2CP1_RS07355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2CP1_RS07370	COG0587	DNA-directed DNA polymerase activity
A2CP1_RS07405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A2CP1_RS07410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A2CP1_RS07415	COG0446	pyridine nucleotide-disulphide oxidoreductase
A2CP1_RS07415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2CP1_RS07430	COG0312	modulator of DNA gyrase
A2CP1_RS07465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2CP1_RS07520	COG1216	Glycosyl transferase, family 2
A2CP1_RS07535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A2CP1_RS07540	COG0009	L-threonylcarbamoyladenylate synthase
A2CP1_RS07550	COG0113	porphobilinogen synthase activity
A2CP1_RS07565	COG1181	Belongs to the D-alanine--D-alanine ligase family
A2CP1_RS07605	COG2205	protein histidine kinase activity
A2CP1_RS07610	COG2201	protein-glutamate methylesterase activity
A2CP1_RS07650	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS07665	COG0557	exoribonuclease II activity
A2CP1_RS07675	COG0730	response to heat
A2CP1_RS07680	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A2CP1_RS07690	COG0411	ABC transporter
A2CP1_RS07715	COG1193	negative regulation of DNA recombination
A2CP1_RS07750	COG1595	DNA-templated transcription, initiation
A2CP1_RS07770	COG3876	Protein conserved in bacteria
A2CP1_RS07790	COG0542	response to heat
A2CP1_RS07815	COG4263	nitrous-oxide reductase activity
A2CP1_RS07845	COG1752	Esterase of the alpha-beta hydrolase superfamily
A2CP1_RS07860	COG0459	protein refolding
A2CP1_RS07865	COG3706	GGDEF domain
A2CP1_RS07880	COG0525	valine-tRNA ligase activity
A2CP1_RS07890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A2CP1_RS07890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A2CP1_RS07910	COG0728	peptidoglycan biosynthetic process
A2CP1_RS07940	COG1595	DNA-templated transcription, initiation
A2CP1_RS07950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2CP1_RS07970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A2CP1_RS07980	COG1573	uracil-dna glycosylase
A2CP1_RS07990	COG0330	HflC and HflK could
A2CP1_RS08005	COG0183	Belongs to the thiolase family
A2CP1_RS08010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A2CP1_RS08030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A2CP1_RS08070	COG0501	Belongs to the peptidase M48B family
A2CP1_RS08090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A2CP1_RS08100	COG0586	Pfam SNARE associated Golgi protein
A2CP1_RS08105	COG0443	Heat shock 70 kDa protein
A2CP1_RS08110	COG0517	IMP dehydrogenase activity
A2CP1_RS08110	COG0516	GMP reductase activity
A2CP1_RS08115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A2CP1_RS08115	COG0519	Catalyzes the synthesis of GMP from XMP
A2CP1_RS08135	COG2204	response regulator
A2CP1_RS08145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A2CP1_RS08155	COG3746	phosphate-selective porin O and P
A2CP1_RS08165	COG1121	(ABC) transporter
A2CP1_RS08180	COG1811	Na channel or pump
A2CP1_RS08195	COG2226	methyltransferase
A2CP1_RS08205	COG0436	Aminotransferase
A2CP1_RS08230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A2CP1_RS08245	COG1234	tRNA 3'-trailer cleavage
A2CP1_RS08255	COG0300	oxidoreductase activity
A2CP1_RS08260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2CP1_RS08260	COG5322	oxidoreductase activity
A2CP1_RS08270	COG0243	molybdopterin cofactor binding
A2CP1_RS08310	COG0596	Alpha beta hydrolase
A2CP1_RS08335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2CP1_RS08360	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A2CP1_RS08365	COG4654	Cytochrome c, class I
A2CP1_RS08390	COG2010	Cytochrome c
A2CP1_RS08395	COG0737	Belongs to the 5'-nucleotidase family
A2CP1_RS08400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2CP1_RS08420	COG1845	cytochrome c oxidase, subunit III
A2CP1_RS08420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A2CP1_RS08440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2CP1_RS08485	COG0443	Heat shock 70 kDa protein
A2CP1_RS08500	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A2CP1_RS08500	COG0392	lysyltransferase activity
A2CP1_RS08515	COG1595	DNA-templated transcription, initiation
A2CP1_RS08575	COG2204	response regulator
A2CP1_RS08590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2CP1_RS08635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A2CP1_RS08645	COG0039	L-malate dehydrogenase activity
A2CP1_RS08680	COG0004	ammonium transporteR
A2CP1_RS08700	COG0583	DNA-binding transcription factor activity
A2CP1_RS08705	COG2814	Major facilitator Superfamily
A2CP1_RS08710	COG0583	DNA-binding transcription factor activity
A2CP1_RS08720	COG2205	protein histidine kinase activity
A2CP1_RS08725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A2CP1_RS08735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A2CP1_RS08740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2CP1_RS08760	COG0583	DNA-binding transcription factor activity
A2CP1_RS08765	COG3118	belongs to the thioredoxin family
A2CP1_RS08790	COG0583	DNA-binding transcription factor activity
A2CP1_RS08805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2CP1_RS08810	COG1592	Rubrerythrin
A2CP1_RS08815	COG2205	protein histidine kinase activity
A2CP1_RS08845	COG0840	transmembrane signaling receptor activity
A2CP1_RS08850	COG0835	chemotaxis
A2CP1_RS08885	COG0683	leucine binding
A2CP1_RS08900	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A2CP1_RS08910	COG2223	nitrite transmembrane transporter activity
A2CP1_RS08925	COG1140	nitrate reductase beta subunit
A2CP1_RS08930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A2CP1_RS08940	COG4191	Histidine kinase
A2CP1_RS08980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2CP1_RS08990	COG0488	(ABC) transporter
A2CP1_RS09005	COG2818	Glycosylase
A2CP1_RS09010	COG1252	NADH dehydrogenase
A2CP1_RS09030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A2CP1_RS09035	COG2204	response regulator
A2CP1_RS09040	COG4191	Histidine kinase
A2CP1_RS09040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2CP1_RS09085	COG0785	Cytochrome C biogenesis protein
A2CP1_RS09100	COG2814	Major facilitator Superfamily
A2CP1_RS09105	COG0252	asparaginase activity
A2CP1_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS09125	COG0559	Belongs to the binding-protein-dependent transport system permease family
A2CP1_RS09150	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A2CP1_RS09160	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2CP1_RS09165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A2CP1_RS09210	COG1595	DNA-templated transcription, initiation
A2CP1_RS09215	COG0667	Aldo Keto reductase
A2CP1_RS09250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A2CP1_RS09260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A2CP1_RS09275	COG0686	Belongs to the AlaDH PNT family
A2CP1_RS09280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A2CP1_RS09290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A2CP1_RS09305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2CP1_RS09310	COG4191	Histidine kinase
A2CP1_RS09310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2CP1_RS09315	COG2204	response regulator
A2CP1_RS09340	COG1053	succinate dehydrogenase
A2CP1_RS09350	COG0156	8-amino-7-oxononanoate synthase activity
A2CP1_RS09360	COG1201	RNA secondary structure unwinding
A2CP1_RS09365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A2CP1_RS09370	COG2205	protein histidine kinase activity
A2CP1_RS09370	COG0784	Response regulator, receiver
A2CP1_RS09380	COG0243	molybdopterin cofactor binding
A2CP1_RS09380	COG3383	formate dehydrogenase (NAD+) activity
A2CP1_RS09385	COG3064	Membrane
A2CP1_RS09385	COG0437	4 iron, 4 sulfur cluster binding
A2CP1_RS09390	COG3058	Necessary for formate dehydrogenase activity
A2CP1_RS09400	COG0626	cystathionine gamma-synthase activity
A2CP1_RS09425	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2CP1_RS09440	COG0667	Aldo Keto reductase
A2CP1_RS09465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2CP1_RS09470	COG0473	3-isopropylmalate dehydrogenase activity
A2CP1_RS09475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A2CP1_RS09475	COG2755	lipolytic protein G-D-S-L family
A2CP1_RS09480	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A2CP1_RS09480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A2CP1_RS09515	COG0488	(ABC) transporter
A2CP1_RS09530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2CP1_RS09540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A2CP1_RS09550	COG1164	Oligoendopeptidase f
A2CP1_RS09570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A2CP1_RS09615	COG0351	phosphomethylpyrimidine kinase
A2CP1_RS09625	COG2095	MarC family integral membrane protein
A2CP1_RS09640	COG1136	(ABC) transporter
A2CP1_RS09645	COG0577	efflux transmembrane transporter activity
A2CP1_RS09660	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A2CP1_RS09670	COG2373	Large extracellular alpha-helical protein
A2CP1_RS09675	COG4953	penicillin-binding protein 1C
A2CP1_RS09715	COG0656	L-ascorbic acid biosynthetic process
A2CP1_RS09745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2CP1_RS09765	COG0501	Belongs to the peptidase M48B family
A2CP1_RS09770	COG0583	DNA-binding transcription factor activity
A2CP1_RS09785	COG0408	coproporphyrinogen oxidase activity
A2CP1_RS09795	COG0788	formyltetrahydrofolate deformylase activity
A2CP1_RS09800	COG5002	protein histidine kinase activity
A2CP1_RS09810	COG2204	response regulator
A2CP1_RS09820	COG3064	Membrane
A2CP1_RS09820	COG0437	4 iron, 4 sulfur cluster binding
A2CP1_RS09825	COG5557	Pfam Polysulphide reductase, NrfD
A2CP1_RS09830	COG0509	glycine decarboxylation via glycine cleavage system
A2CP1_RS09870	COG2197	response regulator
A2CP1_RS09885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A2CP1_RS09890	COG4191	Histidine kinase
A2CP1_RS09900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2CP1_RS09920	COG1217	gtp-binding protein TYPA
A2CP1_RS09935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2CP1_RS09955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2CP1_RS09970	COG0028	Belongs to the TPP enzyme family
A2CP1_RS10000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A2CP1_RS10005	COG0072	phenylalanine-tRNA ligase activity
A2CP1_RS10025	COG2146	nitrite reductase [NAD(P)H] activity
A2CP1_RS10030	COG0720	synthase
A2CP1_RS10035	COG0302	gtp cyclohydrolase
A2CP1_RS10040	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS10045	COG0277	FAD linked oxidase domain protein
A2CP1_RS10050	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2CP1_RS10050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2CP1_RS10055	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2CP1_RS10065	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2CP1_RS10065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2CP1_RS10070	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2CP1_RS10090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2CP1_RS10100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2CP1_RS10105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A2CP1_RS10125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2CP1_RS10130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A2CP1_RS10135	COG0051	transcription antitermination factor activity, RNA binding
A2CP1_RS10175	COG0255	Belongs to the universal ribosomal protein uL29 family
A2CP1_RS10220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A2CP1_RS10235	COG0201	protein transport
A2CP1_RS10250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A2CP1_RS10260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A2CP1_RS10290	COG1837	Belongs to the UPF0109 family
A2CP1_RS10295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A2CP1_RS10315	COG0792	nuclease activity
A2CP1_RS10330	COG3852	Histidine kinase
A2CP1_RS10335	COG0741	lytic transglycosylase activity
A2CP1_RS10360	COG0564	pseudouridine synthase activity
A2CP1_RS10375	COG2226	methyltransferase
A2CP1_RS10385	COG1166	arginine decarboxylase activity
A2CP1_RS10405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2CP1_RS10450	COG0564	pseudouridine synthase activity
A2CP1_RS10460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A2CP1_RS10465	COG1127	ABC transporter
A2CP1_RS10475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2CP1_RS10485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2CP1_RS10515	COG1024	Enoyl-CoA hydratase
A2CP1_RS10520	COG5002	protein histidine kinase activity
A2CP1_RS10530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A2CP1_RS10530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A2CP1_RS10540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A2CP1_RS10550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2CP1_RS10560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A2CP1_RS10565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A2CP1_RS10570	COG0022	dehydrogenase e1 component
A2CP1_RS10580	COG0084	hydrolase, TatD family'
A2CP1_RS10585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A2CP1_RS10590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2CP1_RS10605	COG1297	OPT oligopeptide transporter protein
A2CP1_RS10625	COG0527	aspartate kinase activity
A2CP1_RS10635	COG2183	response to ionizing radiation
A2CP1_RS10660	COG0210	DNA helicase
A2CP1_RS10665	COG0443	Heat shock 70 kDa protein
A2CP1_RS10805	COG2205	protein histidine kinase activity
A2CP1_RS10835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A2CP1_RS10855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A2CP1_RS10860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2CP1_RS10885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A2CP1_RS10915	COG2197	response regulator
A2CP1_RS10930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2CP1_RS10930	COG4191	Histidine kinase
A2CP1_RS10935	COG2204	response regulator
A2CP1_RS10940	COG1027	Aspartate ammonia-lyase
A2CP1_RS10945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A2CP1_RS10950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A2CP1_RS10980	COG5654	RES domain protein
A2CP1_RS10995	COG0024	Methionine aminopeptidase
A2CP1_RS11045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A2CP1_RS11050	COG4208	sulfate ABC transporter
A2CP1_RS11060	COG0175	sulfate reduction
A2CP1_RS11065	COG2895	sulfate adenylyltransferase (ATP) activity
A2CP1_RS11070	COG0175	sulfate reduction
A2CP1_RS11080	COG0742	ribosomal rna small subunit methyltransferase
A2CP1_RS11100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A2CP1_RS11110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A2CP1_RS11125	COG0436	Aminotransferase
A2CP1_RS11140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A2CP1_RS11145	COG1058	Belongs to the CinA family
A2CP1_RS11145	COG1546	Belongs to the CinA family
A2CP1_RS11195	COG2204	response regulator
A2CP1_RS11205	COG2815	serine threonine protein kinase
A2CP1_RS11205	COG0515	serine threonine protein kinase
A2CP1_RS11215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A2CP1_RS11270	COG1215	transferase activity, transferring glycosyl groups
A2CP1_RS11310	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A2CP1_RS11330	COG0189	ligase activity
A2CP1_RS11345	COG0009	L-threonylcarbamoyladenylate synthase
A2CP1_RS11350	COG4974	Belongs to the 'phage' integrase family
A2CP1_RS11355	COG1994	Peptidase M50
A2CP1_RS11360	COG0180	Tryptophanyl-tRNA synthetase
A2CP1_RS11365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A2CP1_RS11370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A2CP1_RS11375	COG1187	pseudouridine synthase activity
A2CP1_RS11405	COG0430	RNA-3'-phosphate cyclase activity
A2CP1_RS11410	COG0598	Magnesium transport protein CorA
A2CP1_RS11420	COG0489	protein tyrosine kinase activity
A2CP1_RS11450	COG2205	protein histidine kinase activity
A2CP1_RS11455	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2CP1_RS11460	COG1024	Enoyl-CoA hydratase
A2CP1_RS11465	COG1960	acyl-CoA dehydrogenase activity
A2CP1_RS11470	COG1960	acyl-CoA dehydrogenase activity
A2CP1_RS11475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2CP1_RS11475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2CP1_RS11495	COG3005	denitrification pathway
A2CP1_RS11505	COG0494	nUDIX hydrolase
A2CP1_RS11520	COG1160	GTP binding
A2CP1_RS11525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A2CP1_RS11540	COG0571	ribonuclease III activity
A2CP1_RS11545	COG1703	isobutyryl-CoA mutase activity
A2CP1_RS11555	COG1960	acyl-CoA dehydrogenase activity
A2CP1_RS11560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A2CP1_RS11565	COG1024	Enoyl-CoA hydratase
A2CP1_RS11600	COG1494	fructose-1,6-bisphosphatase
A2CP1_RS11645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A2CP1_RS11650	COG1253	flavin adenine dinucleotide binding
A2CP1_RS11660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A2CP1_RS11670	COG0039	L-malate dehydrogenase activity
A2CP1_RS11675	COG0538	isocitrate dehydrogenase activity
A2CP1_RS11685	COG4191	Histidine kinase
A2CP1_RS11700	COG0505	Belongs to the CarA family
A2CP1_RS11715	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A2CP1_RS11725	COG0681	Belongs to the peptidase S26 family
A2CP1_RS11735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2CP1_RS11750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A2CP1_RS11770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2CP1_RS11775	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A2CP1_RS11780	COG4191	Histidine kinase
A2CP1_RS11825	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS11900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A2CP1_RS11925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2CP1_RS11935	COG0189	ligase activity
A2CP1_RS11940	COG0443	Heat shock 70 kDa protein
A2CP1_RS11950	COG2921	Belongs to the UPF0250 family
A2CP1_RS11955	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A2CP1_RS11980	COG1309	transcriptional regulator
A2CP1_RS12005	COG1730	sister chromatid segregation
A2CP1_RS12080	COG2204	response regulator
A2CP1_RS12085	COG4191	Histidine kinase
A2CP1_RS12110	COG2766	serine protein kinase
A2CP1_RS12110	COG2766	serine protein kinase
A2CP1_RS12115	COG0443	Heat shock 70 kDa protein
A2CP1_RS12125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A2CP1_RS12140	COG0101	tRNA pseudouridine synthase activity
A2CP1_RS12155	COG0529	Catalyzes the synthesis of activated sulfate
A2CP1_RS12160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2CP1_RS12170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2CP1_RS12180	COG0443	Heat shock 70 kDa protein
A2CP1_RS12205	COG0149	triose-phosphate isomerase activity
A2CP1_RS12215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A2CP1_RS12225	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A2CP1_RS12260	COG0616	signal peptide processing
A2CP1_RS12265	COG0539	negative regulation of cytoplasmic translation
A2CP1_RS12265	COG2183	response to ionizing radiation
A2CP1_RS12285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A2CP1_RS12295	COG0825	malonyl-CoA metabolic process
A2CP1_RS12325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A2CP1_RS12350	COG0802	atpase or kinase
A2CP1_RS12355	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A2CP1_RS12355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A2CP1_RS12365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A2CP1_RS12370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2CP1_RS12380	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A2CP1_RS12385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A2CP1_RS12390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2CP1_RS12395	COG0037	tRNA processing
A2CP1_RS12410	COG0004	ammonium transporteR
A2CP1_RS12425	COG0776	regulation of translation
A2CP1_RS12430	COG3246	L-lysine catabolic process to acetate
A2CP1_RS12435	COG1607	acyl-coa hydrolase
A2CP1_RS12440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A2CP1_RS12450	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A2CP1_RS12455	COG0482	sulfurtransferase activity
A2CP1_RS12460	COG2205	protein histidine kinase activity
A2CP1_RS12465	COG0617	tRNA 3'-terminal CCA addition
A2CP1_RS12480	COG2204	response regulator
A2CP1_RS12505	COG2205	protein histidine kinase activity
A2CP1_RS12510	COG2205	protein histidine kinase activity
A2CP1_RS12515	COG0024	Methionine aminopeptidase
A2CP1_RS12540	COG0840	transmembrane signaling receptor activity
A2CP1_RS12560	COG2353	YceI-like domain
A2CP1_RS12565	COG0259	pyridoxamine-phosphate oxidase activity
A2CP1_RS12585	COG4191	Histidine kinase
A2CP1_RS12590	COG2204	response regulator
A2CP1_RS12595	COG0589	response to stress
A2CP1_RS12620	COG3387	PFAM Glycoside hydrolase 15-related
A2CP1_RS12625	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A2CP1_RS12630	COG0363	glucosamine-6-phosphate deaminase activity
A2CP1_RS12635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A2CP1_RS12640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A2CP1_RS12650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2CP1_RS12670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A2CP1_RS12690	COG0343	queuine tRNA-ribosyltransferase activity
A2CP1_RS12695	COG0429	hydrolase of the alpha beta-hydrolase fold
A2CP1_RS12725	COG0038	chloride channel
A2CP1_RS12795	COG3436	PFAM IS66 Orf2 family protein
A2CP1_RS12815	COG2801	Transposase and inactivated derivatives
A2CP1_RS12825	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A2CP1_RS12830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A2CP1_RS12835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A2CP1_RS12860	COG3604	Transcriptional regulator
A2CP1_RS12865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A2CP1_RS12890	COG1677	Flagellar hook-basal body complex protein FliE
A2CP1_RS12900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A2CP1_RS12940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A2CP1_RS12945	COG1360	Flagellar Motor Protein
A2CP1_RS12950	COG2201	protein-glutamate methylesterase activity
A2CP1_RS12955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A2CP1_RS12960	COG0835	chemotaxis
A2CP1_RS12965	COG0840	transmembrane signaling receptor activity
A2CP1_RS12970	COG2198	Histidine kinase
A2CP1_RS12970	COG0643	Histidine kinase
A2CP1_RS12975	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS12990	COG0835	chemotaxis
A2CP1_RS12995	COG0840	transmembrane signaling receptor activity
A2CP1_RS13000	COG2201	protein-glutamate methylesterase activity
A2CP1_RS13005	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A2CP1_RS13030	COG1639	'signal transduction protein
A2CP1_RS13055	COG1338	Plays a role in the flagellum-specific transport system
A2CP1_RS13060	COG1987	bacterial-type flagellum assembly
A2CP1_RS13065	COG1684	flagellar biosynthetic protein fliR
A2CP1_RS13070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A2CP1_RS13075	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A2CP1_RS13105	COG4786	Flagellar basal body rod
A2CP1_RS13130	COG0739	heme binding
A2CP1_RS13155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A2CP1_RS13160	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A2CP1_RS13175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A2CP1_RS13185	COG0457	Tetratricopeptide repeat
A2CP1_RS13185	COG0463	Glycosyl transferase, family 2
A2CP1_RS13200	COG1763	Mo-molybdopterin cofactor biosynthetic process
A2CP1_RS13205	COG0303	'Molybdopterin
A2CP1_RS13215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A2CP1_RS13225	COG2239	Acts as a magnesium transporter
A2CP1_RS13230	COG2205	protein histidine kinase activity
A2CP1_RS13235	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS13235	COG4566	intracellular signal transduction
A2CP1_RS13240	COG5002	protein histidine kinase activity
A2CP1_RS13245	COG2204	response regulator
A2CP1_RS13250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2CP1_RS13290	COG1335	isochorismatase
A2CP1_RS13295	COG3481	metal-dependent phosphohydrolase, HD sub domain
A2CP1_RS13305	COG0084	hydrolase, TatD family'
A2CP1_RS13310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2CP1_RS13310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2CP1_RS13325	COG3599	regulation of cell shape
A2CP1_RS13390	COG0602	queuosine metabolic process
A2CP1_RS13395	COG0741	lytic transglycosylase activity
A2CP1_RS13435	COG2937	Belongs to the GPAT DAPAT family
A2CP1_RS13445	COG0483	inositol monophosphate 1-phosphatase activity
A2CP1_RS13455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2CP1_RS13460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2CP1_RS13480	COG1045	serine acetyltransferase
A2CP1_RS13495	COG0556	nucleotide-excision repair
A2CP1_RS13505	COG1278	Cold shock
A2CP1_RS13520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A2CP1_RS13520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A2CP1_RS13530	COG2333	competence protein COMEC
A2CP1_RS13530	COG0658	competence protein
A2CP1_RS13570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2CP1_RS13575	COG1309	transcriptional regulator
A2CP1_RS13580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A2CP1_RS13595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A2CP1_RS13600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A2CP1_RS13610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A2CP1_RS13625	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A2CP1_RS13640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A2CP1_RS13655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A2CP1_RS13665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2CP1_RS13680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2CP1_RS13700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2CP1_RS13710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A2CP1_RS13715	COG1278	Cold shock
A2CP1_RS13735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A2CP1_RS13740	COG2766	serine protein kinase
A2CP1_RS13745	COG2718	Belongs to the UPF0229 family
A2CP1_RS13750	COG2719	SpoVR family
A2CP1_RS13770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2CP1_RS13795	COG1047	Peptidyl-prolyl cis-trans
A2CP1_RS13805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A2CP1_RS13810	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS13815	COG3411	Ferredoxin
A2CP1_RS13840	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A2CP1_RS13875	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A2CP1_RS13890	COG5002	protein histidine kinase activity
A2CP1_RS13935	COG1269	ATP hydrolysis coupled proton transport
A2CP1_RS13965	COG2201	protein-glutamate methylesterase activity
A2CP1_RS13970	COG2205	protein histidine kinase activity
A2CP1_RS13980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2CP1_RS14000	COG1309	transcriptional regulator
A2CP1_RS14020	COG1573	uracil-dna glycosylase
A2CP1_RS14025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A2CP1_RS14055	COG0194	GDP metabolic process
A2CP1_RS14060	COG1561	YicC-like family, N-terminal region
A2CP1_RS14070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A2CP1_RS14070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2CP1_RS14075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2CP1_RS14075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A2CP1_RS14080	COG1560	Kdo2-lipid A biosynthetic process
A2CP1_RS14090	COG0859	PFAM glycosyl transferase family 9
A2CP1_RS14095	COG1519	Transferase
A2CP1_RS14105	COG1132	(ABC) transporter
A2CP1_RS14110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2CP1_RS14115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2CP1_RS14130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A2CP1_RS14135	COG2095	MarC family integral membrane protein
A2CP1_RS14140	COG1216	Glycosyl transferase, family 2
A2CP1_RS14175	COG0437	4 iron, 4 sulfur cluster binding
A2CP1_RS14180	COG0243	molybdopterin cofactor binding
A2CP1_RS14195	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS14205	COG1053	succinate dehydrogenase
A2CP1_RS14215	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS14250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A2CP1_RS14265	COG0489	protein tyrosine kinase activity
A2CP1_RS14290	COG2204	response regulator
A2CP1_RS14310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A2CP1_RS14320	COG1136	(ABC) transporter
A2CP1_RS14380	COG0492	ferredoxin-NADP+ reductase activity
A2CP1_RS14415	COG2169	Transcriptional regulator
A2CP1_RS14435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A2CP1_RS14440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A2CP1_RS14475	COG0237	dephospho-CoA kinase activity
A2CP1_RS14500	COG0443	Heat shock 70 kDa protein
A2CP1_RS14515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2CP1_RS14520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A2CP1_RS14550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2CP1_RS14560	COG1652	LysM domain
A2CP1_RS14575	COG5001	Diguanylate cyclase
A2CP1_RS14575	COG4251	negative regulation of phosphorylation
A2CP1_RS14575	COG2203	Gaf domain
A2CP1_RS14575	COG3706	GGDEF domain
A2CP1_RS14580	COG1196	nuclear chromosome segregation
A2CP1_RS14580	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS14590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A2CP1_RS14605	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS14620	COG5492	domain, Protein
A2CP1_RS14620	COG4932	domain protein
A2CP1_RS14635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A2CP1_RS14640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A2CP1_RS14650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A2CP1_RS14655	COG1480	7TM receptor with intracellular HD hydrolase
A2CP1_RS14665	COG0457	Tetratricopeptide repeat
A2CP1_RS14675	COG3956	TIGRFAM MazG family protein
A2CP1_RS14690	COG0495	leucyl-tRNA aminoacylation
A2CP1_RS14695	COG0017	Asparaginyl-tRNA synthetase
A2CP1_RS14700	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS14705	COG2201	protein-glutamate methylesterase activity
A2CP1_RS14710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A2CP1_RS14720	COG0835	chemotaxis
A2CP1_RS14730	COG3267	Type II secretory pathway component ExeA
A2CP1_RS14730	COG3409	Peptidoglycan-binding domain 1 protein
A2CP1_RS14735	COG2198	Histidine kinase
A2CP1_RS14735	COG0643	Histidine kinase
A2CP1_RS14755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2CP1_RS14755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2CP1_RS14765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2CP1_RS14765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2CP1_RS14780	COG0698	ribose 5-phosphate isomerase
A2CP1_RS14790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A2CP1_RS14800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A2CP1_RS14805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A2CP1_RS14815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A2CP1_RS14855	COG2827	Endonuclease containing a URI domain
A2CP1_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS14885	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS14890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A2CP1_RS14905	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A2CP1_RS14920	COG0367	asparagine synthase
A2CP1_RS14925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A2CP1_RS14930	COG0318	PFAM AMP-dependent synthetase and ligase
A2CP1_RS14995	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS15000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A2CP1_RS15020	COG0493	'glutamate synthase
A2CP1_RS15020	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A2CP1_RS15050	COG0515	serine threonine protein kinase
A2CP1_RS15050	COG2815	serine threonine protein kinase
A2CP1_RS15065	COG3186	Phenylalanine-4-hydroxylase
A2CP1_RS15070	COG0488	(ABC) transporter
A2CP1_RS15090	COG2205	protein histidine kinase activity
A2CP1_RS15090	COG0784	Response regulator, receiver
A2CP1_RS15090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2CP1_RS15090	COG2198	Histidine kinase
A2CP1_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS15160	COG4964	Belongs to the GSP D family
A2CP1_RS15260	COG0604	alcohol dehydrogenase
A2CP1_RS15285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2CP1_RS15295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2CP1_RS15310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A2CP1_RS15335	COG1301	dicarboxylic acid transport
A2CP1_RS15350	COG0247	lactate metabolic process
A2CP1_RS15355	COG0277	FAD linked oxidase domain protein
A2CP1_RS15360	COG0277	FAD linked oxidase domain protein
A2CP1_RS15435	COG1309	transcriptional regulator
A2CP1_RS15470	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A2CP1_RS15500	COG2226	methyltransferase
A2CP1_RS15530	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A2CP1_RS15540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A2CP1_RS15545	COG0406	alpha-ribazole phosphatase activity
A2CP1_RS15560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A2CP1_RS15565	COG0702	epimerase
A2CP1_RS15580	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A2CP1_RS15590	COG0318	PFAM AMP-dependent synthetase and ligase
A2CP1_RS15595	COG0671	phosphoesterase, PA-phosphatase related
A2CP1_RS15635	COG1376	ErfK ybiS ycfS ynhG family protein
A2CP1_RS15635	COG1388	LysM domain
A2CP1_RS15650	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS15655	COG2205	protein histidine kinase activity
A2CP1_RS15700	COG1215	transferase activity, transferring glycosyl groups
A2CP1_RS15705	COG1649	PFAM Uncharacterised BCR, COG1649
A2CP1_RS15705	COG0726	polysaccharide deacetylase
A2CP1_RS15715	COG4968	Prepilin-type N-terminal cleavage methylation domain
A2CP1_RS15745	COG1053	succinate dehydrogenase
A2CP1_RS15765	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A2CP1_RS15765	COG1404	Belongs to the peptidase S8 family
A2CP1_RS15790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2CP1_RS15790	COG2205	protein histidine kinase activity
A2CP1_RS15795	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A2CP1_RS15800	COG2205	protein histidine kinase activity
A2CP1_RS15805	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS15860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A2CP1_RS15865	COG0513	Belongs to the DEAD box helicase family
A2CP1_RS15870	COG0784	Response regulator, receiver
A2CP1_RS15870	COG2205	protein histidine kinase activity
A2CP1_RS15880	COG2271	Major facilitator Superfamily
A2CP1_RS15890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2CP1_RS15900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2CP1_RS15900	COG0574	Belongs to the PEP-utilizing enzyme family
A2CP1_RS15905	COG0484	heat shock protein binding
A2CP1_RS15940	COG1136	(ABC) transporter
A2CP1_RS15940	COG0577	efflux transmembrane transporter activity
A2CP1_RS15945	COG4591	ABC-type transport system involved in lipoprotein release permease component
A2CP1_RS15945	COG1136	(ABC) transporter
A2CP1_RS15950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2CP1_RS15955	COG3275	phosphorelay sensor kinase activity
A2CP1_RS15960	COG3279	Response regulator of the LytR AlgR family
A2CP1_RS15970	COG1620	l-lactate permease
A2CP1_RS15980	COG1139	Iron-sulfur cluster binding protein
A2CP1_RS15995	COG4106	trans-aconitate 2-methyltransferase activity
A2CP1_RS16015	COG2264	protein methyltransferase activity
A2CP1_RS16045	COG2860	membrane
A2CP1_RS16075	COG4106	trans-aconitate 2-methyltransferase activity
A2CP1_RS16080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A2CP1_RS16085	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS16095	COG1396	sequence-specific DNA binding
A2CP1_RS16095	COG3800	Transcriptional regulator
A2CP1_RS16105	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A2CP1_RS16125	COG0366	Alpha amylase catalytic
A2CP1_RS16160	COG0318	PFAM AMP-dependent synthetase and ligase
A2CP1_RS16175	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2CP1_RS16180	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2CP1_RS16180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2CP1_RS16190	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A2CP1_RS16205	COG2703	oxygen carrier activity
A2CP1_RS16210	COG0277	FAD linked oxidase domain protein
A2CP1_RS16215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A2CP1_RS16230	COG1960	acyl-CoA dehydrogenase activity
A2CP1_RS16245	COG0702	epimerase
A2CP1_RS16255	COG3272	Protein of unknown function (DUF1722)
A2CP1_RS16265	COG1295	ribonuclease BN
A2CP1_RS16270	COG0443	Heat shock 70 kDa protein
A2CP1_RS16275	COG0443	Heat shock 70 kDa protein
A2CP1_RS16290	COG0667	Aldo Keto reductase
A2CP1_RS16295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2CP1_RS16310	COG0667	Aldo Keto reductase
A2CP1_RS16315	COG0693	protein deglycase activity
A2CP1_RS16355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A2CP1_RS16360	COG1216	Glycosyl transferase, family 2
A2CP1_RS16365	COG1216	Glycosyl transferase, family 2
A2CP1_RS16495	COG0436	Aminotransferase
A2CP1_RS16500	COG0840	transmembrane signaling receptor activity
A2CP1_RS16505	COG0137	argininosuccinate synthase activity
A2CP1_RS16540	COG2204	response regulator
A2CP1_RS16560	COG1733	regulation of RNA biosynthetic process
A2CP1_RS16565	COG0702	epimerase
A2CP1_RS16570	COG0667	Aldo Keto reductase
A2CP1_RS16590	COG2267	carboxylic ester hydrolase activity
A2CP1_RS16610	COG3608	succinylglutamate desuccinylase aspartoacylase
A2CP1_RS16610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A2CP1_RS16615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A2CP1_RS16625	COG0339	signal peptide processing
A2CP1_RS16630	COG3852	Histidine kinase
A2CP1_RS16640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2CP1_RS16645	COG1131	(ABC) transporter
A2CP1_RS16650	COG1131	(ABC) transporter
A2CP1_RS16655	COG0842	Transport permease protein
A2CP1_RS16660	COG0842	Transport permease protein
A2CP1_RS16665	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
A2CP1_RS16670	COG2329	Antibiotic biosynthesis monooxygenase
A2CP1_RS16675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2CP1_RS16675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A2CP1_RS16685	COG3842	ATPase activity
A2CP1_RS16690	COG1175	transmembrane transport
A2CP1_RS16695	COG0395	ABC-type sugar transport system, permease component
A2CP1_RS16710	COG3795	YCII-related domain
A2CP1_RS16725	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A2CP1_RS16730	COG1595	DNA-templated transcription, initiation
A2CP1_RS16735	COG0583	DNA-binding transcription factor activity
A2CP1_RS16745	COG1162	GTPase activity
A2CP1_RS16750	COG2205	protein histidine kinase activity
A2CP1_RS16750	COG0784	Response regulator, receiver
A2CP1_RS16765	COG1309	transcriptional regulator
A2CP1_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS16800	COG0723	plastoquinol--plastocyanin reductase activity
A2CP1_RS16830	COG2855	membrane
A2CP1_RS16900	COG1064	alcohol dehydrogenase
A2CP1_RS16915	COG1131	(ABC) transporter
A2CP1_RS16920	COG0025	NhaP-type Na H and K H
A2CP1_RS16935	COG1473	amidohydrolase
A2CP1_RS16945	COG1278	Cold shock
A2CP1_RS16955	COG0596	Alpha beta hydrolase
A2CP1_RS16975	COG1125	glycine betaine transport
A2CP1_RS16975	COG0517	IMP dehydrogenase activity
A2CP1_RS16980	COG1174	glycine betaine transport
A2CP1_RS16990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A2CP1_RS16995	COG2205	protein histidine kinase activity
A2CP1_RS16995	COG0784	Response regulator, receiver
A2CP1_RS17005	COG3459	Glycosyltransferase 36 associated
A2CP1_RS17010	COG3239	Fatty acid desaturase
A2CP1_RS17055	COG2130	NADP-dependent
A2CP1_RS17065	COG3387	PFAM Glycoside hydrolase 15-related
A2CP1_RS17070	COG1993	acr, cog1993
A2CP1_RS17095	COG2207	Transcriptional regulator
A2CP1_RS17125	COG1595	DNA-templated transcription, initiation
A2CP1_RS17145	COG0006	proline dipeptidase activity
A2CP1_RS17175	COG1918	ferrous iron import across plasma membrane
A2CP1_RS17175	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A2CP1_RS17180	COG0604	alcohol dehydrogenase
A2CP1_RS17315	COG0516	GMP reductase activity
A2CP1_RS17320	COG2132	Multicopper oxidase
A2CP1_RS17330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A2CP1_RS17355	COG1704	LemA family
A2CP1_RS17360	COG0501	Belongs to the peptidase M48B family
A2CP1_RS17370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A2CP1_RS17405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A2CP1_RS17425	COG5337	Spore coat protein CotH
A2CP1_RS17500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A2CP1_RS17535	COG2204	response regulator
A2CP1_RS17555	COG5000	phosphorelay sensor kinase activity
A2CP1_RS17570	COG2252	PERMEase
A2CP1_RS17575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A2CP1_RS17585	COG2136	Putative SAM-dependent methyltransferase
A2CP1_RS17585	COG2521	methyltransferase
A2CP1_RS17605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2CP1_RS17605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2CP1_RS17620	COG0544	peptidyl-prolyl cis-trans isomerase activity
A2CP1_RS17635	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A2CP1_RS17645	COG0463	Glycosyl transferase, family 2
A2CP1_RS17680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A2CP1_RS17695	COG0709	Synthesizes selenophosphate from selenide and ATP
A2CP1_RS17710	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A2CP1_RS17730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A2CP1_RS17740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A2CP1_RS17750	COG0210	DNA helicase
A2CP1_RS17780	COG0564	pseudouridine synthase activity
A2CP1_RS17785	COG0625	glutathione transferase activity
A2CP1_RS17790	COG0612	Peptidase, M16
A2CP1_RS17800	COG4191	Histidine kinase
A2CP1_RS17810	COG1129	ABC transporter
A2CP1_RS17815	COG0739	heme binding
A2CP1_RS17820	COG0483	inositol monophosphate 1-phosphatase activity
A2CP1_RS17835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2CP1_RS17850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A2CP1_RS17860	COG1619	proteins homologs of microcin C7 resistance protein MccF
A2CP1_RS17865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2CP1_RS17870	COG0628	permease
A2CP1_RS17875	COG0545	Peptidyl-prolyl cis-trans isomerase
A2CP1_RS17935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A2CP1_RS17940	COG1136	(ABC) transporter
A2CP1_RS17945	COG4591	ABC-type transport system involved in lipoprotein release permease component
A2CP1_RS17950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2CP1_RS17960	COG0189	ligase activity
A2CP1_RS17980	COG4106	trans-aconitate 2-methyltransferase activity
A2CP1_RS18000	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A2CP1_RS18025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A2CP1_RS18030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A2CP1_RS18035	COG1846	Transcriptional regulator
A2CP1_RS18055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A2CP1_RS18065	COG0471	metal ion transport
A2CP1_RS18065	COG3273	potassium ion transport
A2CP1_RS18085	COG0123	including yeast histone deacetylase and acetoin utilization protein
A2CP1_RS18095	COG3123	guanosine phosphorylase activity
A2CP1_RS18110	COG0587	DNA-directed DNA polymerase activity
A2CP1_RS18115	COG0730	response to heat
A2CP1_RS18125	COG2197	response regulator
A2CP1_RS18130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A2CP1_RS18165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A2CP1_RS18175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A2CP1_RS18200	COG4206	TonB-dependent receptor
A2CP1_RS18210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2CP1_RS18215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2CP1_RS18220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A2CP1_RS18235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A2CP1_RS18240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A2CP1_RS18255	COG3852	Histidine kinase
A2CP1_RS18275	COG2096	Adenosyltransferase
A2CP1_RS18285	COG0316	Belongs to the HesB IscA family
A2CP1_RS18290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2CP1_RS18295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A2CP1_RS18305	COG0746	molybdenum cofactor guanylyltransferase activity
A2CP1_RS18330	COG4106	trans-aconitate 2-methyltransferase activity
A2CP1_RS18340	COG1741	Belongs to the pirin family
A2CP1_RS18375	COG1937	Protein conserved in bacteria
A2CP1_RS18380	COG2217	Heavy metal translocating P-type atpase
A2CP1_RS18395	COG1937	Protein conserved in bacteria
A2CP1_RS18400	COG2217	Heavy metal translocating P-type atpase
A2CP1_RS18415	COG4941	Belongs to the sigma-70 factor family
A2CP1_RS18420	COG3795	YCII-related domain
A2CP1_RS18440	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS18450	COG0667	Aldo Keto reductase
A2CP1_RS18455	COG0583	DNA-binding transcription factor activity
A2CP1_RS18460	COG3118	belongs to the thioredoxin family
A2CP1_RS18470	COG1597	lipid kinase activity
A2CP1_RS18490	COG0840	transmembrane signaling receptor activity
A2CP1_RS18495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A2CP1_RS18505	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS18530	COG0330	HflC and HflK could
A2CP1_RS18555	COG1053	succinate dehydrogenase
A2CP1_RS18555	COG3976	FMN-binding domain protein
A2CP1_RS18580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A2CP1_RS18645	COG4974	Belongs to the 'phage' integrase family
A2CP1_RS18670	COG0739	heme binding
A2CP1_RS18670	COG0741	lytic transglycosylase activity
A2CP1_RS18670	COG1196	nuclear chromosome segregation
A2CP1_RS18675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A2CP1_RS18685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A2CP1_RS18705	COG2267	carboxylic ester hydrolase activity
A2CP1_RS18735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A2CP1_RS18740	COG1090	epimerase
A2CP1_RS18755	COG0750	zinc metalloprotease
A2CP1_RS18765	COG4589	Belongs to the CDS family
A2CP1_RS18770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A2CP1_RS18815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A2CP1_RS18820	COG0459	protein refolding
A2CP1_RS18870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A2CP1_RS18890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A2CP1_RS18895	COG1183	phosphatidylcholine synthase activity
A2CP1_RS18900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A2CP1_RS18950	COG0606	chelatase, subunit chli
A2CP1_RS19010	COG1100	Small GTP-binding protein
A2CP1_RS19020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A2CP1_RS19030	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A2CP1_RS19045	COG0590	tRNA wobble adenosine to inosine editing
A2CP1_RS19060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2CP1_RS19060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A2CP1_RS19085	COG2261	transglycosylase associated protein
A2CP1_RS19125	COG0651	ATP synthesis coupled electron transport
A2CP1_RS19130	COG0651	ATP synthesis coupled electron transport
A2CP1_RS19145	COG0651	ATP synthesis coupled electron transport
A2CP1_RS19150	COG0649	NAD binding
A2CP1_RS19155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A2CP1_RS19175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A2CP1_RS19180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A2CP1_RS19195	COG0475	glutathione-regulated potassium exporter activity
A2CP1_RS19210	COG0739	heme binding
A2CP1_RS19220	COG0539	negative regulation of cytoplasmic translation
A2CP1_RS19260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A2CP1_RS19270	COG1428	Deoxynucleoside kinase
A2CP1_RS19300	COG0484	heat shock protein binding
A2CP1_RS19310	COG0631	protein serine/threonine phosphatase activity
A2CP1_RS19315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A2CP1_RS19335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2CP1_RS19345	COG0477	Major facilitator Superfamily
A2CP1_RS19370	COG0840	transmembrane signaling receptor activity
A2CP1_RS19385	COG0626	cystathionine gamma-synthase activity
A2CP1_RS19400	COG0477	Major facilitator Superfamily
A2CP1_RS19440	COG0840	transmembrane signaling receptor activity
A2CP1_RS19445	COG1902	pentaerythritol trinitrate reductase activity
A2CP1_RS19455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2CP1_RS19460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2CP1_RS19470	COG5002	protein histidine kinase activity
A2CP1_RS19470	COG3850	Histidine kinase
A2CP1_RS19475	COG4122	O-methyltransferase activity
A2CP1_RS19485	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A2CP1_RS19495	COG3852	Histidine kinase
A2CP1_RS19500	COG2204	response regulator
A2CP1_RS19505	COG1271	oxidase subunit
A2CP1_RS19510	COG1294	oxidase, subunit
A2CP1_RS19520	COG2226	methyltransferase
A2CP1_RS19555	COG0515	serine threonine protein kinase
A2CP1_RS19565	COG1024	Enoyl-CoA hydratase
A2CP1_RS19570	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A2CP1_RS19585	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS19595	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A2CP1_RS19605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A2CP1_RS19620	COG0243	molybdopterin cofactor binding
A2CP1_RS19620	COG3383	formate dehydrogenase (NAD+) activity
A2CP1_RS19625	COG3383	formate dehydrogenase (NAD+) activity
A2CP1_RS19625	COG0243	molybdopterin cofactor binding
A2CP1_RS19630	COG0437	4 iron, 4 sulfur cluster binding
A2CP1_RS19635	COG2864	formate dehydrogenase
A2CP1_RS19685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A2CP1_RS19690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A2CP1_RS19700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A2CP1_RS19745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A2CP1_RS19760	COG0640	Transcriptional regulator
A2CP1_RS19780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A2CP1_RS19795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A2CP1_RS19805	COG0577	efflux transmembrane transporter activity
A2CP1_RS19805	COG1136	(ABC) transporter
A2CP1_RS19815	COG1705	Flagellar rod assembly protein muramidase FlgJ
A2CP1_RS19815	COG1388	LysM domain
A2CP1_RS19820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A2CP1_RS19825	COG2204	response regulator
A2CP1_RS19850	COG0793	Belongs to the peptidase S41A family
A2CP1_RS19865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A2CP1_RS19895	COG0673	inositol 2-dehydrogenase activity
A2CP1_RS19905	COG2027	D-alanyl-D-alanine carboxypeptidase
A2CP1_RS19935	COG0640	Transcriptional regulator
A2CP1_RS19955	COG1309	transcriptional regulator
A2CP1_RS19975	COG2003	Belongs to the UPF0758 family
A2CP1_RS19985	COG2353	YceI-like domain
A2CP1_RS19995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2CP1_RS20005	COG0436	Aminotransferase
A2CP1_RS20030	COG1192	Involved in chromosome partitioning
A2CP1_RS20055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A2CP1_RS20060	COG0047	phosphoribosylformylglycinamidine synthase activity
A2CP1_RS20080	COG0312	modulator of DNA gyrase
A2CP1_RS20085	COG0312	modulator of DNA gyrase
A2CP1_RS20100	COG4221	oxidoreductase activity
A2CP1_RS20130	COG2205	protein histidine kinase activity
A2CP1_RS20135	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS20190	COG2801	Transposase and inactivated derivatives
A2CP1_RS20215	COG1061	Type III restriction enzyme res subunit
A2CP1_RS20245	COG1595	DNA-templated transcription, initiation
A2CP1_RS20250	COG1201	RNA secondary structure unwinding
A2CP1_RS20260	COG1074	ATP-dependent DNA helicase activity
A2CP1_RS20270	COG0653	protein targeting
A2CP1_RS20325	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS20340	COG0840	transmembrane signaling receptor activity
A2CP1_RS20350	COG3321	synthase
A2CP1_RS20350	COG0604	alcohol dehydrogenase
A2CP1_RS20350	COG1028	Short-chain dehydrogenase reductase Sdr
A2CP1_RS20355	COG3321	synthase
A2CP1_RS20355	COG0604	alcohol dehydrogenase
A2CP1_RS20365	COG2378	regulation of single-species biofilm formation
A2CP1_RS20385	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A2CP1_RS20400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A2CP1_RS20430	COG0488	(ABC) transporter
A2CP1_RS20485	COG0154	amidase activity
A2CP1_RS20495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A2CP1_RS20500	COG0281	malic enzyme
A2CP1_RS20500	COG0280	phosphate acetyltransferase
A2CP1_RS20515	COG1252	NADH dehydrogenase
A2CP1_RS20545	COG1136	(ABC) transporter
A2CP1_RS20555	COG2840	Smr protein MutS2
A2CP1_RS20570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2CP1_RS20575	COG2239	Acts as a magnesium transporter
A2CP1_RS20600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A2CP1_RS20605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A2CP1_RS20605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2CP1_RS20610	COG0492	ferredoxin-NADP+ reductase activity
A2CP1_RS20640	COG0405	Gamma-glutamyltransferase
A2CP1_RS20650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A2CP1_RS20655	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A2CP1_RS20700	COG2379	hydroxypyruvate reductase
A2CP1_RS20715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A2CP1_RS20720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A2CP1_RS20740	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A2CP1_RS20765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A2CP1_RS20765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A2CP1_RS20775	COG0670	Belongs to the BI1 family
A2CP1_RS20785	COG0584	glycerophosphoryl diester phosphodiesterase
A2CP1_RS20795	COG0488	(ABC) transporter
A2CP1_RS20800	COG2814	Major facilitator Superfamily
A2CP1_RS20860	COG3647	Membrane
A2CP1_RS20875	COG0704	Plays a role in the regulation of phosphate uptake
A2CP1_RS20880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A2CP1_RS20885	COG0581	inorganic phosphate transmembrane transporter activity
A2CP1_RS20890	COG0573	inorganic phosphate transmembrane transporter activity
A2CP1_RS20895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A2CP1_RS20905	COG5002	protein histidine kinase activity
A2CP1_RS20925	COG0116	Belongs to the methyltransferase superfamily
A2CP1_RS20925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2CP1_RS20945	COG2814	Major facilitator Superfamily
A2CP1_RS20970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A2CP1_RS20975	COG2363	Small membrane protein
A2CP1_RS20980	COG2154	pterin-4-alpha-carbinolamine dehydratase
A2CP1_RS20990	COG1408	metallophosphoesterase
A2CP1_RS21035	COG0811	peptide transport
A2CP1_RS21055	COG2030	dehydratase
A2CP1_RS21065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2CP1_RS21080	COG0768	penicillin binding
A2CP1_RS21085	COG0574	Belongs to the PEP-utilizing enzyme family
A2CP1_RS21085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2CP1_RS21090	COG0301	tRNA thio-modification
A2CP1_RS21095	COG0425	Belongs to the sulfur carrier protein TusA family
A2CP1_RS21110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A2CP1_RS21110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2CP1_RS21125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A2CP1_RS21140	COG0134	indole-3-glycerol-phosphate synthase activity
A2CP1_RS21145	COG0135	phosphoribosylanthranilate isomerase activity
A2CP1_RS21150	COG0133	tryptophan synthase activity
A2CP1_RS21155	COG0159	tryptophan synthase activity
A2CP1_RS21165	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A2CP1_RS21195	COG1846	Transcriptional regulator
A2CP1_RS21200	COG0697	spore germination
A2CP1_RS21210	COG0517	IMP dehydrogenase activity
A2CP1_RS21210	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A2CP1_RS21220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A2CP1_RS21225	COG0179	Fumarylacetoacetate (FAA) hydrolase
A2CP1_RS21240	COG0019	diaminopimelate decarboxylase activity
A2CP1_RS21260	COG0346	lactoylglutathione lyase activity
A2CP1_RS21270	COG2715	membrane protein required for spore maturation
A2CP1_RS21275	COG0700	Nucleoside recognition
A2CP1_RS21320	COG0297	glycogen (starch) synthase activity
A2CP1_RS21370	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS21380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A2CP1_RS21390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A2CP1_RS21410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2CP1_RS21420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2CP1_RS21490	COG2198	Histidine kinase
A2CP1_RS21490	COG0784	Response regulator, receiver
A2CP1_RS21490	COG2205	protein histidine kinase activity
A2CP1_RS21505	COG1960	acyl-CoA dehydrogenase activity
A2CP1_RS21520	COG2205	protein histidine kinase activity
A2CP1_RS21520	COG2198	Histidine kinase
A2CP1_RS21520	COG0784	Response regulator, receiver
A2CP1_RS21525	COG5002	protein histidine kinase activity
A2CP1_RS21525	COG0784	Response regulator, receiver
A2CP1_RS21525	COG2198	Histidine kinase
A2CP1_RS21580	COG0395	ABC-type sugar transport system, permease component
A2CP1_RS21585	COG1175	transmembrane transport
A2CP1_RS21595	COG3842	ATPase activity
A2CP1_RS21600	COG0366	Alpha amylase catalytic
A2CP1_RS21645	COG0438	transferase activity, transferring glycosyl groups
A2CP1_RS21650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A2CP1_RS21680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2CP1_RS21685	COG1136	(ABC) transporter
A2CP1_RS21685	COG0577	efflux transmembrane transporter activity
A2CP1_RS21690	COG1136	(ABC) transporter
A2CP1_RS21690	COG0577	efflux transmembrane transporter activity
A2CP1_RS21695	COG0577	efflux transmembrane transporter activity
A2CP1_RS21695	COG1136	(ABC) transporter
A2CP1_RS21700	COG0681	Belongs to the peptidase S26 family
A2CP1_RS21715	COG3259	Nickel-dependent hydrogenase
A2CP1_RS21735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2CP1_RS21765	COG1560	Kdo2-lipid A biosynthetic process
A2CP1_RS21770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A2CP1_RS21775	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A2CP1_RS21805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2CP1_RS21830	COG3339	Conserved Protein
A2CP1_RS21870	COG0457	Tetratricopeptide repeat
A2CP1_RS21875	COG1674	ftsk spoiiie
A2CP1_RS21905	COG0839	Belongs to the complex I subunit 6 family
A2CP1_RS21920	COG0784	Response regulator, receiver
A2CP1_RS21920	COG0835	chemotaxis
A2CP1_RS21945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A2CP1_RS21980	COG2205	protein histidine kinase activity
A2CP1_RS21980	COG0784	Response regulator, receiver
A2CP1_RS22015	COG1193	negative regulation of DNA recombination
A2CP1_RS22020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A2CP1_RS22050	COG5002	protein histidine kinase activity
A2CP1_RS22060	COG0306	phosphate transporter
A2CP1_RS22065	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A2CP1_RS22100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2CP1_RS22130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A2CP1_RS22150	COG3852	Histidine kinase
A2CP1_RS22170	COG2204	response regulator
A2CP1_RS22180	COG0174	glutamine synthetase
A2CP1_RS22205	COG0411	ABC transporter
A2CP1_RS22215	COG0559	Belongs to the binding-protein-dependent transport system permease family
A2CP1_RS22225	COG0745	RESPONSE REGULATOR receiver
A2CP1_RS22240	COG1472	Belongs to the glycosyl hydrolase 3 family
A2CP1_RS22255	COG0714	Associated with various cellular activities
A2CP1_RS22285	COG0489	protein tyrosine kinase activity
A2CP1_RS22285	COG3206	protein involved in exopolysaccharide biosynthesis
A2CP1_RS22290	COG1596	polysaccharide export
A2CP1_RS22310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2CP1_RS22355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2CP1_RS22360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A2CP1_RS22380	COG0463	Glycosyl transferase, family 2
A2CP1_RS22395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A2CP1_RS22420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A2CP1_RS22425	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A2CP1_RS22450	COG3852	Histidine kinase
A2CP1_RS22455	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A2CP1_RS22460	COG1691	(AIR) carboxylase
A2CP1_RS22470	COG0643	Histidine kinase
A2CP1_RS22470	COG2198	Histidine kinase
A2CP1_RS22475	COG2201	protein-glutamate methylesterase activity
A2CP1_RS22485	COG3290	protein histidine kinase activity
A2CP1_RS22485	COG0840	transmembrane signaling receptor activity
A2CP1_RS22490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A2CP1_RS22495	COG2205	protein histidine kinase activity
A2CP1_RS22495	COG2202	Pas domain
A2CP1_RS22500	COG1100	Small GTP-binding protein
A2CP1_RS22505	COG1199	ATP-dependent helicase activity
A2CP1_RS22525	COG0484	heat shock protein binding
A2CP1_RS22530	COG0443	Heat shock 70 kDa protein
A2CP1_RS22535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A2CP1_RS22560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2CP1_RS22565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2CP1_RS22570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A2CP1_RS22575	COG0012	GTP binding
A2CP1_RS22585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A2CP1_RS22630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A2CP1_RS22650	COG0071	Belongs to the small heat shock protein (HSP20) family
A2CP1_RS22660	COG1475	DNA binding
A2CP1_RS22665	COG1192	Involved in chromosome partitioning
A2CP1_RS22695	COG0594	ribonuclease P activity
A2CP1_RS22715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2CP1_RS22795	COG0740	serine-type endopeptidase activity
A2CP1_RS22800	COG0515	serine threonine protein kinase