locus-tag	class	description
ADEH_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ADEH_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ADEH_RS00035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ADEH_RS00055	COG0247	lactate metabolic process
ADEH_RS00055	COG2181	nitrate reductase activity
ADEH_RS00070	COG0189	ligase activity
ADEH_RS00075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ADEH_RS00080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ADEH_RS00085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ADEH_RS00125	COG3852	Histidine kinase
ADEH_RS00140	COG0442	prolyl-tRNA aminoacylation
ADEH_RS00175	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS00190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ADEH_RS00200	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ADEH_RS00210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ADEH_RS00225	COG0280	phosphate acetyltransferase
ADEH_RS00230	COG3426	butyrate kinase activity
ADEH_RS00260	COG2086	electron transfer activity
ADEH_RS00270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ADEH_RS00275	COG0861	Integral membrane protein TerC family
ADEH_RS00295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ADEH_RS00295	COG1793	dna ligase
ADEH_RS00300	COG0564	pseudouridine synthase activity
ADEH_RS00320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ADEH_RS00325	COG0805	protein transport
ADEH_RS00335	COG0183	Belongs to the thiolase family
ADEH_RS00355	COG1032	radical SAM domain protein
ADEH_RS00370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ADEH_RS00375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ADEH_RS00400	COG0352	thiamine-phosphate diphosphorylase activity
ADEH_RS00405	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ADEH_RS00410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ADEH_RS00410	COG0352	thiamine-phosphate diphosphorylase activity
ADEH_RS00410	COG0351	phosphomethylpyrimidine kinase
ADEH_RS00420	COG0305	Participates in initiation and elongation during chromosome replication
ADEH_RS00440	COG1346	cytolysis
ADEH_RS00445	COG1380	Effector of murein hydrolase LrgA
ADEH_RS00450	COG0583	DNA-binding transcription factor activity
ADEH_RS00455	COG0646	methionine synthase
ADEH_RS00455	COG1410	methionine synthase
ADEH_RS00475	COG0433	COG0433 Predicted ATPase
ADEH_RS00480	COG5002	protein histidine kinase activity
ADEH_RS00495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADEH_RS00500	COG1666	GTP binding
ADEH_RS00515	COG0210	DNA helicase
ADEH_RS00520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ADEH_RS00525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ADEH_RS00530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ADEH_RS00540	COG0612	Peptidase, M16
ADEH_RS00545	COG0612	Peptidase, M16
ADEH_RS00560	COG2204	response regulator
ADEH_RS00565	COG3852	Histidine kinase
ADEH_RS00590	COG1077	Cell shape determining protein MreB Mrl
ADEH_RS00595	COG1077	Cell shape determining protein MreB Mrl
ADEH_RS00600	COG1506	peptidase
ADEH_RS00600	COG0823	Involved in the tonB-independent uptake of proteins
ADEH_RS00610	COG0359	binds to the 23S rRNA
ADEH_RS00615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ADEH_RS00620	COG0360	Binds together with S18 to 16S ribosomal RNA
ADEH_RS00625	COG0193	aminoacyl-tRNA hydrolase activity
ADEH_RS00630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ADEH_RS00635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ADEH_RS00640	COG2088	sporulation resulting in formation of a cellular spore
ADEH_RS00645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ADEH_RS00660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ADEH_RS00665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ADEH_RS00690	COG3706	GGDEF domain
ADEH_RS00705	COG0297	glycogen (starch) synthase activity
ADEH_RS00725	COG2022	thiamine diphosphate biosynthetic process
ADEH_RS00725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ADEH_RS00735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ADEH_RS00750	COG2204	response regulator
ADEH_RS00760	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ADEH_RS00765	COG1660	Displays ATPase and GTPase activities
ADEH_RS00770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ADEH_RS00770	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ADEH_RS00785	COG3716	PTS system mannose fructose sorbose family IID component
ADEH_RS00800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ADEH_RS00810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ADEH_RS00815	COG1968	undecaprenyl-diphosphatase activity
ADEH_RS00825	COG0662	Cupin 2, conserved barrel domain protein
ADEH_RS00825	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ADEH_RS00835	COG1846	Transcriptional regulator
ADEH_RS00835	COG1940	carbohydrate kinase activity
ADEH_RS00840	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ADEH_RS00885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ADEH_RS00890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ADEH_RS00905	COG2205	protein histidine kinase activity
ADEH_RS00905	COG0784	Response regulator, receiver
ADEH_RS00925	COG3138	arginine N-succinyltransferase
ADEH_RS00930	COG1490	D-aminoacyl-tRNA deacylase activity
ADEH_RS00935	COG0537	adenosine 5'-monophosphoramidase activity
ADEH_RS00960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ADEH_RS00965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ADEH_RS00970	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ADEH_RS00975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ADEH_RS00980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ADEH_RS00985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ADEH_RS01045	COG0109	protoheme IX farnesyltransferase activity
ADEH_RS01045	COG1612	heme a metabolic process
ADEH_RS01075	COG2814	Major facilitator Superfamily
ADEH_RS01100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ADEH_RS01105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ADEH_RS01115	COG2226	methyltransferase
ADEH_RS01125	COG0697	spore germination
ADEH_RS01135	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADEH_RS01135	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADEH_RS01135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADEH_RS01185	COG1309	transcriptional regulator
ADEH_RS01210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ADEH_RS01215	COG1404	Belongs to the peptidase S8 family
ADEH_RS01220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ADEH_RS01260	COG1297	OPT oligopeptide transporter protein
ADEH_RS01270	COG2264	protein methyltransferase activity
ADEH_RS01275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ADEH_RS01290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ADEH_RS01300	COG1278	Cold shock
ADEH_RS01315	COG0204	Acyl-transferase
ADEH_RS01325	COG5002	protein histidine kinase activity
ADEH_RS01330	COG4770	biotin carboxylase activity
ADEH_RS01335	COG5016	pyruvate
ADEH_RS01335	COG0511	ligase activity, forming carbon-carbon bonds
ADEH_RS01340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADEH_RS01340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADEH_RS01345	COG0484	heat shock protein binding
ADEH_RS01370	COG0564	pseudouridine synthase activity
ADEH_RS01375	COG0848	biopolymer transport protein
ADEH_RS01385	COG0811	peptide transport
ADEH_RS01405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ADEH_RS01425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ADEH_RS01425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ADEH_RS01430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ADEH_RS01435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ADEH_RS01440	COG0617	tRNA 3'-terminal CCA addition
ADEH_RS01445	COG0528	UMP kinase activity
ADEH_RS01450	COG0233	cytoplasmic translational termination
ADEH_RS01470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ADEH_RS01470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ADEH_RS01500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ADEH_RS01515	COG1640	4-alpha-glucanotransferase
ADEH_RS01520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ADEH_RS01540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ADEH_RS01550	COG4191	Histidine kinase
ADEH_RS01560	COG2839	Protein conserved in bacteria
ADEH_RS01595	COG1942	4-Oxalocrotonate Tautomerase
ADEH_RS01605	COG0583	DNA-binding transcription factor activity
ADEH_RS01615	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ADEH_RS01665	COG0308	aminopeptidase N
ADEH_RS01670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ADEH_RS01725	COG4206	TonB-dependent receptor
ADEH_RS01785	COG0693	protein deglycase activity
ADEH_RS01790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ADEH_RS01805	COG2855	membrane
ADEH_RS01810	COG0583	DNA-binding transcription factor activity
ADEH_RS01850	COG1024	Enoyl-CoA hydratase
ADEH_RS01850	COG1250	3-hydroxyacyl-CoA dehydrogenase
ADEH_RS01855	COG0183	Belongs to the thiolase family
ADEH_RS01860	COG1960	acyl-CoA dehydrogenase activity
ADEH_RS01875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ADEH_RS01880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ADEH_RS01885	COG2890	protein-(glutamine-N5) methyltransferase activity
ADEH_RS01890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ADEH_RS01895	COG0784	Response regulator, receiver
ADEH_RS01895	COG2205	protein histidine kinase activity
ADEH_RS01910	COG0402	S-adenosylhomocysteine deaminase activity
ADEH_RS01915	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ADEH_RS01920	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ADEH_RS01925	COG0163	prenyltransferase activity
ADEH_RS01930	COG2226	methyltransferase
ADEH_RS01935	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ADEH_RS01945	COG0612	Peptidase, M16
ADEH_RS01985	COG0542	response to heat
ADEH_RS01990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ADEH_RS02005	COG0318	PFAM AMP-dependent synthetase and ligase
ADEH_RS02040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ADEH_RS02065	COG1234	tRNA 3'-trailer cleavage
ADEH_RS02070	COG1741	Belongs to the pirin family
ADEH_RS02080	COG1131	(ABC) transporter
ADEH_RS02095	COG0183	Belongs to the thiolase family
ADEH_RS02100	COG1250	3-hydroxyacyl-CoA dehydrogenase
ADEH_RS02100	COG1024	Enoyl-CoA hydratase
ADEH_RS02115	COG0745	RESPONSE REGULATOR receiver
ADEH_RS02125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ADEH_RS02150	COG3852	Histidine kinase
ADEH_RS02160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ADEH_RS02165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ADEH_RS02175	COG1088	dTDP-glucose 4,6-dehydratase activity
ADEH_RS02180	COG0204	Acyl-transferase
ADEH_RS02190	COG1846	Transcriptional regulator
ADEH_RS02205	COG3706	GGDEF domain
ADEH_RS02215	COG0708	Exodeoxyribonuclease III
ADEH_RS02230	COG0420	3'-5' exonuclease activity
ADEH_RS02240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ADEH_RS02265	COG1136	(ABC) transporter
ADEH_RS02265	COG0577	efflux transmembrane transporter activity
ADEH_RS02305	COG1309	transcriptional regulator
ADEH_RS02315	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ADEH_RS02325	COG0667	Aldo Keto reductase
ADEH_RS02345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ADEH_RS02345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ADEH_RS02350	COG3639	organic phosphonate transmembrane transporter activity
ADEH_RS02355	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ADEH_RS02390	COG0439	Biotin carboxylase
ADEH_RS02410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ADEH_RS02415	COG3875	lactate racemase activity
ADEH_RS02445	COG0298	carbon dioxide binding
ADEH_RS02450	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ADEH_RS02455	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ADEH_RS02460	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ADEH_RS02465	COG5557	Pfam Polysulphide reductase, NrfD
ADEH_RS02470	COG0437	4 iron, 4 sulfur cluster binding
ADEH_RS02475	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ADEH_RS02505	COG1285	pathogenesis
ADEH_RS02510	COG2119	membrane
ADEH_RS02535	COG1122	ATPase activity
ADEH_RS02545	COG0310	cobalt ion transport
ADEH_RS02555	COG0864	Transcriptional regulator
ADEH_RS02560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ADEH_RS02560	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ADEH_RS02585	COG2205	protein histidine kinase activity
ADEH_RS02600	COG5002	protein histidine kinase activity
ADEH_RS02605	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ADEH_RS02605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ADEH_RS02610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADEH_RS02610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADEH_RS02615	COG2133	pyrroloquinoline quinone binding
ADEH_RS02620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ADEH_RS02665	COG1309	transcriptional regulator
ADEH_RS02670	COG0366	Alpha amylase catalytic
ADEH_RS02680	COG0596	Alpha beta hydrolase
ADEH_RS02690	COG2832	Protein of unknown function (DUF454)
ADEH_RS02720	COG0671	phosphoesterase, PA-phosphatase related
ADEH_RS02725	COG1752	Esterase of the alpha-beta hydrolase superfamily
ADEH_RS02735	COG0436	Aminotransferase
ADEH_RS02745	COG3047	cAMP biosynthetic process
ADEH_RS02760	COG1122	ATPase activity
ADEH_RS02765	COG1268	BioY protein
ADEH_RS02770	COG0400	carboxylic ester hydrolase activity
ADEH_RS02780	COG0583	DNA-binding transcription factor activity
ADEH_RS02795	COG0667	Aldo Keto reductase
ADEH_RS02815	COG0596	Alpha beta hydrolase
ADEH_RS02820	COG0583	DNA-binding transcription factor activity
ADEH_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS02915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ADEH_RS02925	COG1228	amidohydrolase
ADEH_RS02930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ADEH_RS02935	COG2204	response regulator
ADEH_RS02960	COG0612	Peptidase, M16
ADEH_RS02965	COG5002	protein histidine kinase activity
ADEH_RS02990	COG0745	RESPONSE REGULATOR receiver
ADEH_RS03010	COG1438	arginine binding
ADEH_RS03015	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ADEH_RS03020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ADEH_RS03040	COG4232	protein-disulfide reductase activity
ADEH_RS03045	COG1104	cysteine desulfurase activity
ADEH_RS03055	COG0316	Belongs to the HesB IscA family
ADEH_RS03060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ADEH_RS03065	COG0443	Heat shock 70 kDa protein
ADEH_RS03080	COG2201	protein-glutamate methylesterase activity
ADEH_RS03090	COG0835	chemotaxis
ADEH_RS03095	COG2198	Histidine kinase
ADEH_RS03095	COG0643	Histidine kinase
ADEH_RS03100	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ADEH_RS03110	COG0745	RESPONSE REGULATOR receiver
ADEH_RS03125	COG0745	RESPONSE REGULATOR receiver
ADEH_RS03150	COG2201	protein-glutamate methylesterase activity
ADEH_RS03160	COG0784	Response regulator, receiver
ADEH_RS03165	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ADEH_RS03170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ADEH_RS03180	COG0295	cytidine deaminase activity
ADEH_RS03185	COG0196	riboflavin kinase activity
ADEH_RS03190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ADEH_RS03200	COG1459	type II secretion system
ADEH_RS03205	COG3852	Histidine kinase
ADEH_RS03255	COG4968	Prepilin-type N-terminal cleavage methylation domain
ADEH_RS03260	COG1131	(ABC) transporter
ADEH_RS03265	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ADEH_RS03275	COG2204	response regulator
ADEH_RS03320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ADEH_RS03325	COG0511	ligase activity, forming carbon-carbon bonds
ADEH_RS03330	COG0439	Biotin carboxylase
ADEH_RS03340	COG3409	Peptidoglycan-binding domain 1 protein
ADEH_RS03340	COG3267	Type II secretory pathway component ExeA
ADEH_RS03355	COG2217	Heavy metal translocating P-type atpase
ADEH_RS03375	COG0823	Involved in the tonB-independent uptake of proteins
ADEH_RS03400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ADEH_RS03410	COG2884	Cell division ATP-binding protein ftsE
ADEH_RS03415	COG2177	Part of the ABC transporter FtsEX involved in
ADEH_RS03420	COG4942	peptidase
ADEH_RS03425	COG0793	Belongs to the peptidase S41A family
ADEH_RS03430	COG1215	transferase activity, transferring glycosyl groups
ADEH_RS03440	COG0546	phosphoglycolate phosphatase activity
ADEH_RS03445	COG0552	protein localization to endoplasmic reticulum
ADEH_RS03450	COG1196	nuclear chromosome segregation
ADEH_RS03455	COG3290	protein histidine kinase activity
ADEH_RS03455	COG0840	transmembrane signaling receptor activity
ADEH_RS03490	COG2165	general secretion pathway protein
ADEH_RS03505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ADEH_RS03510	COG1450	Type ii and iii secretion system protein
ADEH_RS03530	COG0254	rRNA binding
ADEH_RS03535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ADEH_RS03550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ADEH_RS03555	COG1254	Belongs to the acylphosphatase family
ADEH_RS03565	COG1530	ribonuclease E activity
ADEH_RS03565	COG1530	ribonuclease E activity
ADEH_RS03570	COG1295	ribonuclease BN
ADEH_RS03575	COG0776	regulation of translation
ADEH_RS03585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ADEH_RS03595	COG1987	bacterial-type flagellum assembly
ADEH_RS03610	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ADEH_RS03645	COG2197	response regulator
ADEH_RS03650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ADEH_RS03655	COG0131	Imidazoleglycerol-phosphate dehydratase
ADEH_RS03660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ADEH_RS03665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ADEH_RS03670	COG0107	imidazoleglycerol-phosphate synthase activity
ADEH_RS03715	COG1584	GPR1 FUN34 yaaH family protein
ADEH_RS03720	COG0242	peptide deformylase activity
ADEH_RS03730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ADEH_RS03745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ADEH_RS03750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ADEH_RS03755	COG0497	DNA recombination
ADEH_RS03760	COG0631	protein serine/threonine phosphatase activity
ADEH_RS03765	COG0739	heme binding
ADEH_RS03775	COG0653	protein targeting
ADEH_RS03805	COG1595	DNA-templated transcription, initiation
ADEH_RS03825	COG0604	alcohol dehydrogenase
ADEH_RS03830	COG0583	DNA-binding transcription factor activity
ADEH_RS03835	COG0628	permease
ADEH_RS03850	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ADEH_RS03855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ADEH_RS03860	COG0739	heme binding
ADEH_RS03865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ADEH_RS03880	COG1881	PFAM PEBP family protein
ADEH_RS03895	COG0348	domain, Protein
ADEH_RS03900	COG2962	Rard protein
ADEH_RS03905	COG0589	response to stress
ADEH_RS03910	COG0167	dihydroorotate dehydrogenase activity
ADEH_RS03930	COG0247	lactate metabolic process
ADEH_RS03990	COG1253	flavin adenine dinucleotide binding
ADEH_RS04000	COG2264	protein methyltransferase activity
ADEH_RS04010	COG0508	dehydrogenase complex catalyzes the overall conversion of
ADEH_RS04035	COG1643	Atp-dependent helicase
ADEH_RS04040	COG0071	Belongs to the small heat shock protein (HSP20) family
ADEH_RS04060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ADEH_RS04070	COG1595	DNA-templated transcription, initiation
ADEH_RS04080	COG0437	4 iron, 4 sulfur cluster binding
ADEH_RS04115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ADEH_RS04125	COG1845	cytochrome c oxidase, subunit III
ADEH_RS04140	COG0028	Belongs to the TPP enzyme family
ADEH_RS04145	COG4948	Mandelate Racemase Muconate Lactonizing
ADEH_RS04150	COG0277	FAD linked oxidase domain protein
ADEH_RS04150	COG0247	lactate metabolic process
ADEH_RS04155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ADEH_RS04165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ADEH_RS04180	COG1793	dna ligase
ADEH_RS04185	COG0070	glutamate synthase
ADEH_RS04185	COG0069	glutamate synthase activity
ADEH_RS04185	COG0067	glutamate synthase
ADEH_RS04190	COG0493	'glutamate synthase
ADEH_RS04205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ADEH_RS04215	COG0437	4 iron, 4 sulfur cluster binding
ADEH_RS04220	COG3383	formate dehydrogenase (NAD+) activity
ADEH_RS04220	COG0243	molybdopterin cofactor binding
ADEH_RS04225	COG0243	molybdopterin cofactor binding
ADEH_RS04230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ADEH_RS04235	COG3973	AAA domain
ADEH_RS04240	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ADEH_RS04250	COG0488	(ABC) transporter
ADEH_RS04255	COG1012	belongs to the aldehyde dehydrogenase family
ADEH_RS04270	COG4191	Histidine kinase
ADEH_RS04275	COG1131	(ABC) transporter
ADEH_RS04280	COG0842	Transport permease protein
ADEH_RS04290	COG0514	ATP-dependent DNA helicase (RecQ)
ADEH_RS04305	COG4681	YaeQ
ADEH_RS04315	COG0719	Fe-S assembly protein
ADEH_RS04320	COG0396	ATPase activity
ADEH_RS04325	COG0719	Fe-S assembly protein
ADEH_RS04330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ADEH_RS04360	COG0793	Belongs to the peptidase S41A family
ADEH_RS04370	COG1136	(ABC) transporter
ADEH_RS04370	COG0577	efflux transmembrane transporter activity
ADEH_RS04375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ADEH_RS04385	COG2197	response regulator
ADEH_RS04400	COG0023	Translation Initiation Factor
ADEH_RS04420	COG0058	SHG alpha-glucan phosphorylase activity
ADEH_RS04430	COG1704	LemA family
ADEH_RS04455	COG1396	sequence-specific DNA binding
ADEH_RS04460	COG0745	RESPONSE REGULATOR receiver
ADEH_RS04535	COG0668	transmembrane transport
ADEH_RS04560	COG0745	RESPONSE REGULATOR receiver
ADEH_RS04565	COG2205	protein histidine kinase activity
ADEH_RS04570	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ADEH_RS04575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ADEH_RS04580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ADEH_RS04595	COG2322	membrane
ADEH_RS04610	COG0109	protoheme IX farnesyltransferase activity
ADEH_RS04620	COG0037	tRNA processing
ADEH_RS04625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ADEH_RS04630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ADEH_RS04645	COG0243	molybdopterin cofactor binding
ADEH_RS04655	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ADEH_RS04665	COG2132	Multicopper oxidase
ADEH_RS04720	COG2204	response regulator
ADEH_RS04725	COG4191	Histidine kinase
ADEH_RS04730	COG2873	o-acetylhomoserine
ADEH_RS04745	COG0432	Pfam Uncharacterised protein family UPF0047
ADEH_RS04750	COG0003	Pfam Anion-transporting ATPase
ADEH_RS04765	COG1192	Involved in chromosome partitioning
ADEH_RS04775	COG2353	YceI-like domain
ADEH_RS04780	COG3384	dioxygenase
ADEH_RS04785	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ADEH_RS04800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ADEH_RS04805	COG0584	glycerophosphoryl diester phosphodiesterase
ADEH_RS04815	COG1271	oxidase subunit
ADEH_RS04820	COG1294	oxidase, subunit
ADEH_RS04835	COG1331	Highly conserved protein containing a thioredoxin domain
ADEH_RS04865	COG3158	transport of potassium into the cell
ADEH_RS04870	COG2814	Major facilitator Superfamily
ADEH_RS04875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ADEH_RS04880	COG0632	four-way junction helicase activity
ADEH_RS04885	COG2255	four-way junction helicase activity
ADEH_RS04895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ADEH_RS04930	COG3285	dna ligase
ADEH_RS04930	COG1793	dna ligase
ADEH_RS04945	COG0427	acetyl-CoA hydrolase
ADEH_RS04955	COG0745	RESPONSE REGULATOR receiver
ADEH_RS04965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ADEH_RS05000	COG2814	Major facilitator Superfamily
ADEH_RS05035	COG2205	protein histidine kinase activity
ADEH_RS05035	COG2202	Pas domain
ADEH_RS05045	COG4783	chaperone-mediated protein folding
ADEH_RS05060	COG1278	Cold shock
ADEH_RS05085	COG1720	tRNA m6t6A37 methyltransferase activity
ADEH_RS05110	COG3842	ATPase activity
ADEH_RS05140	COG4603	Belongs to the binding-protein-dependent transport system permease family
ADEH_RS05145	COG3845	ABC transporter
ADEH_RS05150	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ADEH_RS05205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ADEH_RS05230	COG3239	Fatty acid desaturase
ADEH_RS05235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ADEH_RS05240	COG0798	PFAM Bile acid sodium symporter
ADEH_RS05270	COG2226	methyltransferase
ADEH_RS05275	COG1335	isochorismatase
ADEH_RS05335	COG1335	isochorismatase
ADEH_RS05340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ADEH_RS05355	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ADEH_RS05360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ADEH_RS05365	COG1692	metallophosphoesterase
ADEH_RS05380	COG1104	cysteine desulfurase activity
ADEH_RS05390	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ADEH_RS05410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ADEH_RS05420	COG2204	response regulator
ADEH_RS05450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ADEH_RS05460	COG0673	inositol 2-dehydrogenase activity
ADEH_RS05480	COG1132	(ABC) transporter
ADEH_RS05485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ADEH_RS05490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ADEH_RS05500	COG5000	phosphorelay sensor kinase activity
ADEH_RS05525	COG1543	Belongs to the glycosyl hydrolase 57 family
ADEH_RS05535	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ADEH_RS05545	COG1136	(ABC) transporter
ADEH_RS05550	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ADEH_RS05560	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ADEH_RS05565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ADEH_RS05575	COG3494	Protein of unknown function (DUF1009)
ADEH_RS05580	COG1872	DUF167
ADEH_RS05585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ADEH_RS05590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ADEH_RS05595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ADEH_RS05600	COG0484	heat shock protein binding
ADEH_RS05610	COG1570	exodeoxyribonuclease VII activity
ADEH_RS05615	COG1722	exodeoxyribonuclease VII activity
ADEH_RS05620	COG0745	RESPONSE REGULATOR receiver
ADEH_RS05625	COG0142	geranyltranstransferase activity
ADEH_RS05630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ADEH_RS05635	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ADEH_RS05640	COG0779	Required for maturation of 30S ribosomal subunits
ADEH_RS05655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ADEH_RS05665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ADEH_RS05670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ADEH_RS05680	COG1185	polyribonucleotide nucleotidyltransferase activity
ADEH_RS05685	COG0756	dUTP diphosphatase activity
ADEH_RS05690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ADEH_RS05720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ADEH_RS05730	COG0546	phosphoglycolate phosphatase activity
ADEH_RS05740	COG0745	RESPONSE REGULATOR receiver
ADEH_RS05745	COG0314	molybdopterin synthase activity
ADEH_RS05750	COG0750	zinc metalloprotease
ADEH_RS05760	COG2816	NAD+ diphosphatase activity
ADEH_RS05800	COG5002	protein histidine kinase activity
ADEH_RS05810	COG1960	acyl-CoA dehydrogenase activity
ADEH_RS05815	COG1324	tolerance protein
ADEH_RS05825	COG0515	serine threonine protein kinase
ADEH_RS05835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ADEH_RS05840	COG0616	signal peptide processing
ADEH_RS05845	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ADEH_RS05850	COG1607	acyl-coa hydrolase
ADEH_RS05870	COG1408	metallophosphoesterase
ADEH_RS05895	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ADEH_RS05900	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ADEH_RS05925	COG1100	Small GTP-binding protein
ADEH_RS05965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ADEH_RS05965	COG2755	lipolytic protein G-D-S-L family
ADEH_RS05970	COG1064	alcohol dehydrogenase
ADEH_RS05985	COG0318	PFAM AMP-dependent synthetase and ligase
ADEH_RS05990	COG3875	lactate racemase activity
ADEH_RS06010	COG0243	molybdopterin cofactor binding
ADEH_RS06015	COG3278	Belongs to the heme-copper respiratory oxidase family
ADEH_RS06030	COG0348	domain, Protein
ADEH_RS06045	COG2217	Heavy metal translocating P-type atpase
ADEH_RS06055	COG1049	propionate catabolic process, 2-methylcitrate cycle
ADEH_RS06085	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ADEH_RS06090	COG1573	uracil-dna glycosylase
ADEH_RS06110	COG1309	transcriptional regulator
ADEH_RS06130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ADEH_RS06140	COG2205	protein histidine kinase activity
ADEH_RS06145	COG2201	protein-glutamate methylesterase activity
ADEH_RS06150	COG2198	Histidine kinase
ADEH_RS06150	COG0643	Histidine kinase
ADEH_RS06150	COG0784	Response regulator, receiver
ADEH_RS06150	COG0643	Histidine kinase
ADEH_RS06150	COG2198	Histidine kinase
ADEH_RS06150	COG0784	Response regulator, receiver
ADEH_RS06175	COG1269	ATP hydrolysis coupled proton transport
ADEH_RS06200	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
ADEH_RS06205	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
ADEH_RS06210	COG1394	ATPase activity, coupled to movement of substances
ADEH_RS06220	COG5002	protein histidine kinase activity
ADEH_RS06225	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS06235	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ADEH_RS06255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ADEH_RS06275	COG3411	Ferredoxin
ADEH_RS06285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ADEH_RS06295	COG1047	Peptidyl-prolyl cis-trans
ADEH_RS06340	COG2719	SpoVR family
ADEH_RS06345	COG2718	Belongs to the UPF0229 family
ADEH_RS06350	COG2766	serine protein kinase
ADEH_RS06355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ADEH_RS06360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ADEH_RS06375	COG1278	Cold shock
ADEH_RS06380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ADEH_RS06390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ADEH_RS06410	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ADEH_RS06415	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ADEH_RS06425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ADEH_RS06435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ADEH_RS06450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ADEH_RS06465	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ADEH_RS06480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ADEH_RS06485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ADEH_RS06490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ADEH_RS06495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ADEH_RS06510	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ADEH_RS06515	COG1309	transcriptional regulator
ADEH_RS06520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ADEH_RS06530	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ADEH_RS06535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ADEH_RS06560	COG0658	competence protein
ADEH_RS06560	COG2333	competence protein COMEC
ADEH_RS06570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ADEH_RS06570	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ADEH_RS06575	COG0215	cysteine-tRNA ligase activity
ADEH_RS06585	COG1278	Cold shock
ADEH_RS06595	COG0556	nucleotide-excision repair
ADEH_RS06610	COG3258	Cytochrome c
ADEH_RS06615	COG0322	excinuclease ABC activity
ADEH_RS06625	COG1045	serine acetyltransferase
ADEH_RS06645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ADEH_RS06650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ADEH_RS06660	COG0483	inositol monophosphate 1-phosphatase activity
ADEH_RS06670	COG2937	Belongs to the GPAT DAPAT family
ADEH_RS06695	COG0167	dihydroorotate dehydrogenase activity
ADEH_RS06710	COG0741	lytic transglycosylase activity
ADEH_RS06715	COG0602	queuosine metabolic process
ADEH_RS06740	COG1381	Involved in DNA repair and RecF pathway recombination
ADEH_RS06750	COG0752	glycyl-tRNA synthetase alpha subunit
ADEH_RS06755	COG0751	glycine-tRNA ligase activity
ADEH_RS06780	COG3599	regulation of cell shape
ADEH_RS06785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ADEH_RS06795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADEH_RS06795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADEH_RS06800	COG0084	hydrolase, TatD family'
ADEH_RS06815	COG1335	isochorismatase
ADEH_RS06860	COG2204	response regulator
ADEH_RS06865	COG4191	Histidine kinase
ADEH_RS06870	COG0745	RESPONSE REGULATOR receiver
ADEH_RS06870	COG4566	intracellular signal transduction
ADEH_RS06875	COG2205	protein histidine kinase activity
ADEH_RS06880	COG2239	Acts as a magnesium transporter
ADEH_RS06890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ADEH_RS06900	COG0303	'Molybdopterin
ADEH_RS06905	COG1763	Mo-molybdopterin cofactor biosynthetic process
ADEH_RS06920	COG0463	Glycosyl transferase, family 2
ADEH_RS06920	COG0457	Tetratricopeptide repeat
ADEH_RS06930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ADEH_RS06945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ADEH_RS06950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ADEH_RS06975	COG0739	heme binding
ADEH_RS06980	COG1706	bacterial-type flagellum-dependent cell motility
ADEH_RS06985	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ADEH_RS07000	COG4786	Flagellar basal body rod
ADEH_RS07035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ADEH_RS07040	COG1684	flagellar biosynthetic protein fliR
ADEH_RS07045	COG1987	bacterial-type flagellum assembly
ADEH_RS07050	COG1338	Plays a role in the flagellum-specific transport system
ADEH_RS07075	COG1639	'signal transduction protein
ADEH_RS07080	COG0745	RESPONSE REGULATOR receiver
ADEH_RS07100	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ADEH_RS07105	COG2201	protein-glutamate methylesterase activity
ADEH_RS07110	COG0840	transmembrane signaling receptor activity
ADEH_RS07115	COG0835	chemotaxis
ADEH_RS07135	COG0643	Histidine kinase
ADEH_RS07135	COG2198	Histidine kinase
ADEH_RS07140	COG0840	transmembrane signaling receptor activity
ADEH_RS07145	COG0835	chemotaxis
ADEH_RS07150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ADEH_RS07155	COG2201	protein-glutamate methylesterase activity
ADEH_RS07165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ADEH_RS07205	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ADEH_RS07215	COG1677	Flagellar hook-basal body complex protein FliE
ADEH_RS07240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ADEH_RS07245	COG3604	Transcriptional regulator
ADEH_RS07270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ADEH_RS07275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ADEH_RS07280	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ADEH_RS07340	COG0038	chloride channel
ADEH_RS07350	COG0437	4 iron, 4 sulfur cluster binding
ADEH_RS07370	COG0429	hydrolase of the alpha beta-hydrolase fold
ADEH_RS07375	COG0343	queuine tRNA-ribosyltransferase activity
ADEH_RS07395	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ADEH_RS07415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ADEH_RS07425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ADEH_RS07430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ADEH_RS07435	COG0363	glucosamine-6-phosphate deaminase activity
ADEH_RS07440	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ADEH_RS07445	COG3387	PFAM Glycoside hydrolase 15-related
ADEH_RS07470	COG1067	ATP-dependent peptidase activity
ADEH_RS07475	COG0589	response to stress
ADEH_RS07480	COG0517	IMP dehydrogenase activity
ADEH_RS07485	COG2204	response regulator
ADEH_RS07490	COG4191	Histidine kinase
ADEH_RS07510	COG0259	pyridoxamine-phosphate oxidase activity
ADEH_RS07515	COG2353	YceI-like domain
ADEH_RS07555	COG4974	Belongs to the 'phage' integrase family
ADEH_RS07580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ADEH_RS07610	COG2205	protein histidine kinase activity
ADEH_RS07630	COG1538	Outer membrane efflux protein
ADEH_RS07650	COG0617	tRNA 3'-terminal CCA addition
ADEH_RS07655	COG2198	Histidine kinase
ADEH_RS07655	COG2205	protein histidine kinase activity
ADEH_RS07655	COG0784	Response regulator, receiver
ADEH_RS07660	COG0482	sulfurtransferase activity
ADEH_RS07665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ADEH_RS07675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADEH_RS07680	COG1607	acyl-coa hydrolase
ADEH_RS07685	COG3246	L-lysine catabolic process to acetate
ADEH_RS07690	COG0776	regulation of translation
ADEH_RS07705	COG0004	ammonium transporteR
ADEH_RS07720	COG0590	tRNA wobble adenosine to inosine editing
ADEH_RS07720	COG0037	tRNA processing
ADEH_RS07725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ADEH_RS07730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ADEH_RS07735	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ADEH_RS07745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ADEH_RS07750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ADEH_RS07755	COG0736	holo-[acyl-carrier-protein] synthase activity
ADEH_RS07760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ADEH_RS07760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ADEH_RS07765	COG0802	atpase or kinase
ADEH_RS07785	COG1228	amidohydrolase
ADEH_RS07790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ADEH_RS07810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ADEH_RS07815	COG0825	malonyl-CoA metabolic process
ADEH_RS07825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ADEH_RS07850	COG0539	negative regulation of cytoplasmic translation
ADEH_RS07850	COG2183	response to ionizing radiation
ADEH_RS07855	COG0616	signal peptide processing
ADEH_RS07870	COG0018	arginyl-trna synthetase
ADEH_RS07890	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ADEH_RS07900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ADEH_RS07905	COG0126	phosphoglycerate kinase activity
ADEH_RS07910	COG0149	triose-phosphate isomerase activity
ADEH_RS07935	COG0443	Heat shock 70 kDa protein
ADEH_RS07945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ADEH_RS07955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ADEH_RS07960	COG2046	Belongs to the sulfate adenylyltransferase family
ADEH_RS07960	COG0529	Catalyzes the synthesis of activated sulfate
ADEH_RS07975	COG0101	tRNA pseudouridine synthase activity
ADEH_RS07990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ADEH_RS08000	COG0443	Heat shock 70 kDa protein
ADEH_RS08005	COG2766	serine protein kinase
ADEH_RS08005	COG2766	serine protein kinase
ADEH_RS08025	COG2843	Capsule synthesis protein
ADEH_RS08030	COG4191	Histidine kinase
ADEH_RS08035	COG2204	response regulator
ADEH_RS08110	COG1730	sister chromatid segregation
ADEH_RS08160	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ADEH_RS08165	COG2921	Belongs to the UPF0250 family
ADEH_RS08175	COG0443	Heat shock 70 kDa protein
ADEH_RS08180	COG0189	ligase activity
ADEH_RS08190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ADEH_RS08215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ADEH_RS08245	COG0081	regulation of translation
ADEH_RS08250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ADEH_RS08255	COG0222	ribosome binding
ADEH_RS08260	COG0085	RNA polymerase activity
ADEH_RS08265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ADEH_RS08290	COG0745	RESPONSE REGULATOR receiver
ADEH_RS08335	COG4191	Histidine kinase
ADEH_RS08340	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ADEH_RS08345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ADEH_RS08355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ADEH_RS08365	COG0587	DNA-directed DNA polymerase activity
ADEH_RS08370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ADEH_RS08375	COG0481	GTPase activity
ADEH_RS08380	COG0681	Belongs to the peptidase S26 family
ADEH_RS08390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ADEH_RS08395	COG0540	Belongs to the ATCase OTCase family
ADEH_RS08400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ADEH_RS08405	COG0505	Belongs to the CarA family
ADEH_RS08420	COG5002	protein histidine kinase activity
ADEH_RS08430	COG0538	isocitrate dehydrogenase activity
ADEH_RS08435	COG0039	L-malate dehydrogenase activity
ADEH_RS08440	COG0045	succinate-CoA ligase (ADP-forming) activity
ADEH_RS08445	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ADEH_RS08450	COG0105	UTP biosynthetic process
ADEH_RS08455	COG1253	flavin adenine dinucleotide binding
ADEH_RS08460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ADEH_RS08505	COG1494	fructose-1,6-bisphosphatase
ADEH_RS08520	COG0148	phosphopyruvate hydratase activity
ADEH_RS08525	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ADEH_RS08540	COG1024	Enoyl-CoA hydratase
ADEH_RS08545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ADEH_RS08550	COG1960	acyl-CoA dehydrogenase activity
ADEH_RS08560	COG1703	isobutyryl-CoA mutase activity
ADEH_RS08565	COG0571	ribonuclease III activity
ADEH_RS08580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ADEH_RS08585	COG1160	GTP binding
ADEH_RS08600	COG0494	nUDIX hydrolase
ADEH_RS08615	COG3005	denitrification pathway
ADEH_RS08635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADEH_RS08635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADEH_RS08640	COG1960	acyl-CoA dehydrogenase activity
ADEH_RS08645	COG1960	acyl-CoA dehydrogenase activity
ADEH_RS08650	COG1024	Enoyl-CoA hydratase
ADEH_RS08655	COG1250	3-hydroxyacyl-CoA dehydrogenase
ADEH_RS08660	COG2205	protein histidine kinase activity
ADEH_RS08690	COG0489	protein tyrosine kinase activity
ADEH_RS08700	COG0598	Magnesium transport protein CorA
ADEH_RS08705	COG0430	RNA-3'-phosphate cyclase activity
ADEH_RS08735	COG1187	pseudouridine synthase activity
ADEH_RS08740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ADEH_RS08745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ADEH_RS08750	COG0180	Tryptophanyl-tRNA synthetase
ADEH_RS08755	COG1994	Peptidase M50
ADEH_RS08760	COG4974	Belongs to the 'phage' integrase family
ADEH_RS08765	COG0009	L-threonylcarbamoyladenylate synthase
ADEH_RS08780	COG0189	ligase activity
ADEH_RS08785	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ADEH_RS08795	COG0860	N-Acetylmuramoyl-L-alanine amidase
ADEH_RS08800	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ADEH_RS08815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ADEH_RS08830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ADEH_RS08865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ADEH_RS08875	COG0515	serine threonine protein kinase
ADEH_RS08875	COG2815	serine threonine protein kinase
ADEH_RS08885	COG2204	response regulator
ADEH_RS08905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ADEH_RS08935	COG1546	Belongs to the CinA family
ADEH_RS08935	COG1058	Belongs to the CinA family
ADEH_RS08940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ADEH_RS08955	COG0436	Aminotransferase
ADEH_RS08965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ADEH_RS08970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ADEH_RS08980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ADEH_RS08995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ADEH_RS09000	COG0742	ribosomal rna small subunit methyltransferase
ADEH_RS09065	COG0024	Methionine aminopeptidase
ADEH_RS09100	COG5654	RES domain protein
ADEH_RS09120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ADEH_RS09125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ADEH_RS09130	COG1027	Aspartate ammonia-lyase
ADEH_RS09135	COG2204	response regulator
ADEH_RS09140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ADEH_RS09140	COG4191	Histidine kinase
ADEH_RS09155	COG2197	response regulator
ADEH_RS09175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ADEH_RS09200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ADEH_RS09205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ADEH_RS09225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ADEH_RS09255	COG2205	protein histidine kinase activity
ADEH_RS09395	COG0443	Heat shock 70 kDa protein
ADEH_RS09400	COG0210	DNA helicase
ADEH_RS09430	COG2986	histidine ammonia-lyase
ADEH_RS09435	COG0527	aspartate kinase activity
ADEH_RS09450	COG0515	serine threonine protein kinase
ADEH_RS09450	COG2815	serine threonine protein kinase
ADEH_RS09470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ADEH_RS09475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ADEH_RS09490	COG0022	dehydrogenase e1 component
ADEH_RS09495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ADEH_RS09500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ADEH_RS09510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ADEH_RS09520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADEH_RS09520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADEH_RS09530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADEH_RS09530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADEH_RS09625	COG1024	Enoyl-CoA hydratase
ADEH_RS09650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ADEH_RS09660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ADEH_RS09670	COG1127	ABC transporter
ADEH_RS09675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ADEH_RS09685	COG0564	pseudouridine synthase activity
ADEH_RS09835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ADEH_RS09855	COG1166	arginine decarboxylase activity
ADEH_RS09865	COG2226	methyltransferase
ADEH_RS09880	COG0564	pseudouridine synthase activity
ADEH_RS09905	COG0741	lytic transglycosylase activity
ADEH_RS09910	COG5002	protein histidine kinase activity
ADEH_RS09920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ADEH_RS09925	COG0792	nuclease activity
ADEH_RS09935	COG0335	large ribosomal subunit rRNA binding
ADEH_RS09940	COG0336	Belongs to the RNA methyltransferase TrmD family
ADEH_RS09945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ADEH_RS09950	COG1837	Belongs to the UPF0109 family
ADEH_RS09965	COG0203	ribosomal protein L17
ADEH_RS09970	COG0202	RNA polymerase activity
ADEH_RS09980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ADEH_RS09990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ADEH_RS10000	COG0563	adenylate kinase activity
ADEH_RS10005	COG0201	protein transport
ADEH_RS10010	COG0200	Binds to the 23S rRNA
ADEH_RS10020	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ADEH_RS10025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ADEH_RS10030	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ADEH_RS10035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ADEH_RS10050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ADEH_RS10065	COG0255	Belongs to the universal ribosomal protein uL29 family
ADEH_RS10070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ADEH_RS10075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ADEH_RS10085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ADEH_RS10090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ADEH_RS10095	COG0089	rRNA binding
ADEH_RS10100	COG0088	Forms part of the polypeptide exit tunnel
ADEH_RS10105	COG0051	transcription antitermination factor activity, RNA binding
ADEH_RS10110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ADEH_RS10115	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ADEH_RS10120	COG0049	tRNA binding
ADEH_RS10135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ADEH_RS10140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ADEH_RS10170	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADEH_RS10175	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADEH_RS10175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADEH_RS10185	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADEH_RS10190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADEH_RS10190	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADEH_RS10195	COG0277	FAD linked oxidase domain protein
ADEH_RS10205	COG0302	gtp cyclohydrolase
ADEH_RS10210	COG0720	synthase
ADEH_RS10215	COG2146	nitrite reductase [NAD(P)H] activity
ADEH_RS10225	COG0776	regulation of translation
ADEH_RS10235	COG0072	phenylalanine-tRNA ligase activity
ADEH_RS10240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ADEH_RS10245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ADEH_RS10250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ADEH_RS10255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ADEH_RS10275	COG0066	3-isopropylmalate dehydratase activity
ADEH_RS10280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ADEH_RS10285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ADEH_RS10290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ADEH_RS10305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ADEH_RS10320	COG1217	gtp-binding protein TYPA
ADEH_RS10325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ADEH_RS10340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ADEH_RS10345	COG2204	response regulator
ADEH_RS10355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ADEH_RS10370	COG2197	response regulator
ADEH_RS10375	COG4585	Histidine kinase
ADEH_RS10410	COG0509	glycine decarboxylation via glycine cleavage system
ADEH_RS10415	COG5557	Pfam Polysulphide reductase, NrfD
ADEH_RS10420	COG3064	Membrane
ADEH_RS10420	COG0437	4 iron, 4 sulfur cluster binding
ADEH_RS10430	COG2204	response regulator
ADEH_RS10440	COG5002	protein histidine kinase activity
ADEH_RS10445	COG0788	formyltetrahydrofolate deformylase activity
ADEH_RS10455	COG0408	coproporphyrinogen oxidase activity
ADEH_RS10470	COG0583	DNA-binding transcription factor activity
ADEH_RS10495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ADEH_RS10525	COG0656	L-ascorbic acid biosynthetic process
ADEH_RS10565	COG4953	penicillin-binding protein 1C
ADEH_RS10570	COG2373	Large extracellular alpha-helical protein
ADEH_RS10580	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ADEH_RS10595	COG0577	efflux transmembrane transporter activity
ADEH_RS10600	COG1136	(ABC) transporter
ADEH_RS10615	COG2095	MarC family integral membrane protein
ADEH_RS10620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ADEH_RS10630	COG0351	phosphomethylpyrimidine kinase
ADEH_RS10645	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ADEH_RS10665	COG1164	Oligoendopeptidase f
ADEH_RS10675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ADEH_RS10685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ADEH_RS10700	COG0488	(ABC) transporter
ADEH_RS10730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ADEH_RS10735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ADEH_RS10735	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ADEH_RS10740	COG2755	lipolytic protein G-D-S-L family
ADEH_RS10740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ADEH_RS10745	COG0473	3-isopropylmalate dehydrogenase activity
ADEH_RS10750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ADEH_RS10775	COG0667	Aldo Keto reductase
ADEH_RS10780	COG0328	RNA-DNA hybrid ribonuclease activity
ADEH_RS10790	COG2195	Cleaves the N-terminal amino acid of tripeptides
ADEH_RS10815	COG0626	cystathionine gamma-synthase activity
ADEH_RS10830	COG0437	4 iron, 4 sulfur cluster binding
ADEH_RS10830	COG3064	Membrane
ADEH_RS10835	COG3383	formate dehydrogenase (NAD+) activity
ADEH_RS10835	COG0243	molybdopterin cofactor binding
ADEH_RS10845	COG2205	protein histidine kinase activity
ADEH_RS10845	COG0784	Response regulator, receiver
ADEH_RS10850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ADEH_RS10855	COG1201	RNA secondary structure unwinding
ADEH_RS10865	COG0156	8-amino-7-oxononanoate synthase activity
ADEH_RS10870	COG1063	alcohol dehydrogenase
ADEH_RS10875	COG1053	succinate dehydrogenase
ADEH_RS10895	COG1301	dicarboxylic acid transport
ADEH_RS10900	COG2204	response regulator
ADEH_RS10905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ADEH_RS10905	COG4191	Histidine kinase
ADEH_RS10910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ADEH_RS10925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ADEH_RS10930	COG2226	methyltransferase
ADEH_RS10935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ADEH_RS10940	COG0686	Belongs to the AlaDH PNT family
ADEH_RS10955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ADEH_RS10965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ADEH_RS10995	COG0667	Aldo Keto reductase
ADEH_RS11000	COG1595	DNA-templated transcription, initiation
ADEH_RS11045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ADEH_RS11050	COG0508	dehydrogenase complex catalyzes the overall conversion of
ADEH_RS11060	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
ADEH_RS11085	COG0559	Belongs to the binding-protein-dependent transport system permease family
ADEH_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS11105	COG0252	asparaginase activity
ADEH_RS11110	COG2814	Major facilitator Superfamily
ADEH_RS11125	COG0785	Cytochrome C biogenesis protein
ADEH_RS11160	COG1252	NADH dehydrogenase
ADEH_RS11165	COG2818	Glycosylase
ADEH_RS11180	COG0488	(ABC) transporter
ADEH_RS11235	COG4191	Histidine kinase
ADEH_RS11245	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ADEH_RS11250	COG1140	nitrate reductase beta subunit
ADEH_RS11265	COG2223	nitrite transmembrane transporter activity
ADEH_RS11275	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ADEH_RS11285	COG0730	response to heat
ADEH_RS11290	COG0683	leucine binding
ADEH_RS11315	COG0217	transcriptional regulatory protein
ADEH_RS11325	COG0835	chemotaxis
ADEH_RS11330	COG0840	transmembrane signaling receptor activity
ADEH_RS11360	COG1592	Rubrerythrin
ADEH_RS11365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ADEH_RS11380	COG0583	DNA-binding transcription factor activity
ADEH_RS11405	COG3118	belongs to the thioredoxin family
ADEH_RS11410	COG0583	DNA-binding transcription factor activity
ADEH_RS11425	COG1741	Belongs to the pirin family
ADEH_RS11430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ADEH_RS11435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ADEH_RS11445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ADEH_RS11450	COG2205	protein histidine kinase activity
ADEH_RS11460	COG0583	DNA-binding transcription factor activity
ADEH_RS11465	COG2814	Major facilitator Superfamily
ADEH_RS11490	COG0004	ammonium transporteR
ADEH_RS11530	COG0039	L-malate dehydrogenase activity
ADEH_RS11540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ADEH_RS11580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ADEH_RS11595	COG2204	response regulator
ADEH_RS11620	COG2259	Doxx family
ADEH_RS11660	COG1595	DNA-templated transcription, initiation
ADEH_RS11665	COG2267	carboxylic ester hydrolase activity
ADEH_RS11675	COG3604	Transcriptional regulator
ADEH_RS11685	COG2072	flavoprotein involved in K transport
ADEH_RS11690	COG0644	oxidoreductase
ADEH_RS11695	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ADEH_RS11695	COG0392	lysyltransferase activity
ADEH_RS11715	COG0443	Heat shock 70 kDa protein
ADEH_RS11760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ADEH_RS11775	COG1845	cytochrome c oxidase, subunit III
ADEH_RS11780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ADEH_RS11780	COG1845	cytochrome c oxidase, subunit III
ADEH_RS11805	COG0737	Belongs to the 5'-nucleotidase family
ADEH_RS11810	COG2010	Cytochrome c
ADEH_RS11835	COG4654	Cytochrome c, class I
ADEH_RS11840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ADEH_RS11870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ADEH_RS11930	COG0243	molybdopterin cofactor binding
ADEH_RS11935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ADEH_RS11935	COG5322	oxidoreductase activity
ADEH_RS11940	COG0300	oxidoreductase activity
ADEH_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS11955	COG3347	Dehydrogenase
ADEH_RS11965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ADEH_RS11985	COG0436	Aminotransferase
ADEH_RS12000	COG2985	domain, Protein
ADEH_RS12000	COG0569	domain protein
ADEH_RS12025	COG1811	Na channel or pump
ADEH_RS12040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ADEH_RS12045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ADEH_RS12100	COG1121	(ABC) transporter
ADEH_RS12110	COG3746	phosphate-selective porin O and P
ADEH_RS12120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ADEH_RS12130	COG0745	RESPONSE REGULATOR receiver
ADEH_RS12130	COG4566	intracellular signal transduction
ADEH_RS12150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ADEH_RS12150	COG0519	Catalyzes the synthesis of GMP from XMP
ADEH_RS12155	COG0517	IMP dehydrogenase activity
ADEH_RS12155	COG0516	GMP reductase activity
ADEH_RS12160	COG0443	Heat shock 70 kDa protein
ADEH_RS12165	COG0586	Pfam SNARE associated Golgi protein
ADEH_RS12175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ADEH_RS12185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADEH_RS12195	COG0501	Belongs to the peptidase M48B family
ADEH_RS12210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ADEH_RS12230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ADEH_RS12235	COG0183	Belongs to the thiolase family
ADEH_RS12250	COG0330	HflC and HflK could
ADEH_RS12260	COG1573	uracil-dna glycosylase
ADEH_RS12270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ADEH_RS12290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ADEH_RS12300	COG1595	DNA-templated transcription, initiation
ADEH_RS12345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ADEH_RS12350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ADEH_RS12350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ADEH_RS12360	COG0525	valine-tRNA ligase activity
ADEH_RS12365	COG0745	RESPONSE REGULATOR receiver
ADEH_RS12375	COG3706	GGDEF domain
ADEH_RS12380	COG0459	protein refolding
ADEH_RS12390	COG1752	Esterase of the alpha-beta hydrolase superfamily
ADEH_RS12420	COG4263	nitrous-oxide reductase activity
ADEH_RS12445	COG0542	response to heat
ADEH_RS12455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ADEH_RS12465	COG3876	Protein conserved in bacteria
ADEH_RS12485	COG1595	DNA-templated transcription, initiation
ADEH_RS12500	COG0438	transferase activity, transferring glycosyl groups
ADEH_RS12520	COG1193	negative regulation of DNA recombination
ADEH_RS12545	COG0411	ABC transporter
ADEH_RS12555	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ADEH_RS12560	COG0730	response to heat
ADEH_RS12570	COG0557	exoribonuclease II activity
ADEH_RS12580	COG0303	'Molybdopterin
ADEH_RS12585	COG0745	RESPONSE REGULATOR receiver
ADEH_RS12595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ADEH_RS12600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADEH_RS12625	COG2201	protein-glutamate methylesterase activity
ADEH_RS12630	COG2205	protein histidine kinase activity
ADEH_RS12660	COG1181	Belongs to the D-alanine--D-alanine ligase family
ADEH_RS12675	COG0113	porphobilinogen synthase activity
ADEH_RS12685	COG0009	L-threonylcarbamoyladenylate synthase
ADEH_RS12690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ADEH_RS12705	COG1216	Glycosyl transferase, family 2
ADEH_RS12755	COG0138	bifunctional purine biosynthesis protein purh
ADEH_RS12760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ADEH_RS12795	COG0312	modulator of DNA gyrase
ADEH_RS12815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ADEH_RS12820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ADEH_RS12855	COG0587	DNA-directed DNA polymerase activity
ADEH_RS12870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ADEH_RS12875	COG0585	pseudouridine synthase activity
ADEH_RS12890	COG0181	hydroxymethylbilane synthase activity
ADEH_RS12895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ADEH_RS12910	COG3118	belongs to the thioredoxin family
ADEH_RS12915	COG0772	Belongs to the SEDS family
ADEH_RS12920	COG0768	penicillin binding
ADEH_RS12935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ADEH_RS12940	COG0424	maF-like protein
ADEH_RS12945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ADEH_RS12985	COG1830	Aldolase
ADEH_RS12995	COG1074	ATP-dependent DNA helicase activity
ADEH_RS13000	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ADEH_RS13015	COG0352	thiamine-phosphate diphosphorylase activity
ADEH_RS13025	COG2022	thiamine diphosphate biosynthetic process
ADEH_RS13050	COG0612	Peptidase, M16
ADEH_RS13055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ADEH_RS13070	COG1597	lipid kinase activity
ADEH_RS13095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ADEH_RS13100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ADEH_RS13110	COG0604	alcohol dehydrogenase
ADEH_RS13115	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ADEH_RS13115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ADEH_RS13130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ADEH_RS13135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ADEH_RS13140	COG1862	Preprotein translocase
ADEH_RS13145	COG0343	queuine tRNA-ribosyltransferase activity
ADEH_RS13155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ADEH_RS13160	COG2385	sporulation resulting in formation of a cellular spore
ADEH_RS13165	COG0586	Pfam SNARE associated Golgi protein
ADEH_RS13195	COG0011	TIGRFAM Protein of
ADEH_RS13205	COG1716	ATPase activity
ADEH_RS13230	COG0521	Mo-molybdopterin cofactor biosynthetic process
ADEH_RS13240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ADEH_RS13240	COG1796	DNA polymerase
ADEH_RS13245	COG2223	nitrite transmembrane transporter activity
ADEH_RS13260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS13265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ADEH_RS13275	COG0649	NAD binding
ADEH_RS13280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS13285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS13290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS13295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS13300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS13305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS13310	COG0649	NAD binding
ADEH_RS13315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ADEH_RS13320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS13330	COG0713	ATP synthesis coupled electron transport
ADEH_RS13345	COG1007	ATP synthesis coupled electron transport
ADEH_RS13350	COG0613	PHP domain protein
ADEH_RS13355	COG1959	2 iron, 2 sulfur cluster binding
ADEH_RS13360	COG0010	Belongs to the arginase family
ADEH_RS13365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ADEH_RS13375	COG0484	heat shock protein binding
ADEH_RS13380	COG0443	Heat shock 70 kDa protein
ADEH_RS13390	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ADEH_RS13410	COG1355	regulation of microtubule-based process
ADEH_RS13425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ADEH_RS13435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ADEH_RS13460	COG0114	fumarate hydratase activity
ADEH_RS13510	COG0194	GDP metabolic process
ADEH_RS13515	COG1561	YicC-like family, N-terminal region
ADEH_RS13525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ADEH_RS13525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ADEH_RS13530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ADEH_RS13530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ADEH_RS13535	COG1560	Kdo2-lipid A biosynthetic process
ADEH_RS13540	COG1663	tetraacyldisaccharide 4'-kinase activity
ADEH_RS13545	COG0859	PFAM glycosyl transferase family 9
ADEH_RS13550	COG1519	Transferase
ADEH_RS13560	COG1132	(ABC) transporter
ADEH_RS13565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ADEH_RS13570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ADEH_RS13585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ADEH_RS13590	COG2095	MarC family integral membrane protein
ADEH_RS13595	COG0463	Glycosyl transferase, family 2
ADEH_RS13600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ADEH_RS13630	COG0437	4 iron, 4 sulfur cluster binding
ADEH_RS13635	COG0243	molybdopterin cofactor binding
ADEH_RS13650	COG0745	RESPONSE REGULATOR receiver
ADEH_RS13660	COG1053	succinate dehydrogenase
ADEH_RS13670	COG0438	transferase activity, transferring glycosyl groups
ADEH_RS13705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ADEH_RS13710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ADEH_RS13720	COG0489	protein tyrosine kinase activity
ADEH_RS13745	COG2204	response regulator
ADEH_RS13765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ADEH_RS13775	COG1136	(ABC) transporter
ADEH_RS13835	COG0492	ferredoxin-NADP+ reductase activity
ADEH_RS13865	COG2169	Transcriptional regulator
ADEH_RS13885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ADEH_RS13910	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ADEH_RS13925	COG0237	dephospho-CoA kinase activity
ADEH_RS13950	COG0443	Heat shock 70 kDa protein
ADEH_RS13965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ADEH_RS13970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ADEH_RS13975	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ADEH_RS13990	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ADEH_RS14000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ADEH_RS14010	COG1652	LysM domain
ADEH_RS14025	COG4251	negative regulation of phosphorylation
ADEH_RS14025	COG2203	Gaf domain
ADEH_RS14025	COG3706	GGDEF domain
ADEH_RS14025	COG5001	Diguanylate cyclase
ADEH_RS14030	COG0745	RESPONSE REGULATOR receiver
ADEH_RS14030	COG1196	nuclear chromosome segregation
ADEH_RS14040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ADEH_RS14055	COG0438	transferase activity, transferring glycosyl groups
ADEH_RS14070	COG5492	domain, Protein
ADEH_RS14070	COG4932	domain protein
ADEH_RS14085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ADEH_RS14090	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ADEH_RS14100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ADEH_RS14105	COG1480	7TM receptor with intracellular HD hydrolase
ADEH_RS14115	COG0457	Tetratricopeptide repeat
ADEH_RS14125	COG3956	TIGRFAM MazG family protein
ADEH_RS14130	COG0268	Binds directly to 16S ribosomal RNA
ADEH_RS14140	COG0495	leucyl-tRNA aminoacylation
ADEH_RS14145	COG0017	Asparaginyl-tRNA synthetase
ADEH_RS14150	COG0745	RESPONSE REGULATOR receiver
ADEH_RS14155	COG2201	protein-glutamate methylesterase activity
ADEH_RS14170	COG0835	chemotaxis
ADEH_RS14175	COG0835	chemotaxis
ADEH_RS14180	COG3267	Type II secretory pathway component ExeA
ADEH_RS14180	COG3409	Peptidoglycan-binding domain 1 protein
ADEH_RS14185	COG0643	Histidine kinase
ADEH_RS14185	COG2198	Histidine kinase
ADEH_RS14200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ADEH_RS14205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADEH_RS14205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADEH_RS14215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ADEH_RS14215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ADEH_RS14220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ADEH_RS14225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ADEH_RS14230	COG0698	ribose 5-phosphate isomerase
ADEH_RS14240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ADEH_RS14250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ADEH_RS14255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ADEH_RS14260	COG0416	fatty acid biosynthetic process
ADEH_RS14265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ADEH_RS14305	COG2827	Endonuclease containing a URI domain
ADEH_RS14310	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS14330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ADEH_RS14335	COG0438	transferase activity, transferring glycosyl groups
ADEH_RS14340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ADEH_RS14370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ADEH_RS14390	COG1215	transferase activity, transferring glycosyl groups
ADEH_RS14410	COG3291	Pkd domain containing protein
ADEH_RS14415	COG0367	asparagine synthase
ADEH_RS14430	COG1696	Membrane protein involved in D-alanine export
ADEH_RS14440	COG0318	PFAM AMP-dependent synthetase and ligase
ADEH_RS14455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ADEH_RS14460	COG0367	asparagine synthase
ADEH_RS14470	COG0493	'glutamate synthase
ADEH_RS14470	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ADEH_RS14500	COG2815	serine threonine protein kinase
ADEH_RS14500	COG0515	serine threonine protein kinase
ADEH_RS14520	COG3186	Phenylalanine-4-hydroxylase
ADEH_RS14525	COG0488	(ABC) transporter
ADEH_RS14535	COG0745	RESPONSE REGULATOR receiver
ADEH_RS14545	COG2198	Histidine kinase
ADEH_RS14545	COG2205	protein histidine kinase activity
ADEH_RS14545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ADEH_RS14545	COG0784	Response regulator, receiver
ADEH_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS14645	COG2894	cell division
ADEH_RS14650	COG4964	Belongs to the GSP D family
ADEH_RS14730	COG0604	alcohol dehydrogenase
ADEH_RS14755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ADEH_RS14770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ADEH_RS14775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ADEH_RS14780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ADEH_RS14795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ADEH_RS14820	COG1301	dicarboxylic acid transport
ADEH_RS14830	COG0071	Belongs to the small heat shock protein (HSP20) family
ADEH_RS14840	COG0247	lactate metabolic process
ADEH_RS14845	COG0277	FAD linked oxidase domain protein
ADEH_RS14850	COG0277	FAD linked oxidase domain protein
ADEH_RS14900	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ADEH_RS14935	COG1022	Amp-dependent synthetase and ligase
ADEH_RS14955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ADEH_RS14965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ADEH_RS14970	COG0406	alpha-ribazole phosphatase activity
ADEH_RS14980	COG1032	radical SAM domain protein
ADEH_RS14990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ADEH_RS14995	COG0702	epimerase
ADEH_RS15015	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ADEH_RS15025	COG0318	PFAM AMP-dependent synthetase and ligase
ADEH_RS15030	COG0671	phosphoesterase, PA-phosphatase related
ADEH_RS15065	COG1388	LysM domain
ADEH_RS15065	COG1376	ErfK ybiS ycfS ynhG family protein
ADEH_RS15080	COG0745	RESPONSE REGULATOR receiver
ADEH_RS15085	COG2205	protein histidine kinase activity
ADEH_RS15135	COG1215	transferase activity, transferring glycosyl groups
ADEH_RS15140	COG0726	polysaccharide deacetylase
ADEH_RS15140	COG1649	PFAM Uncharacterised BCR, COG1649
ADEH_RS15150	COG4968	Prepilin-type N-terminal cleavage methylation domain
ADEH_RS15180	COG1053	succinate dehydrogenase
ADEH_RS15200	COG1404	Belongs to the peptidase S8 family
ADEH_RS15200	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ADEH_RS15225	COG5002	protein histidine kinase activity
ADEH_RS15230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ADEH_RS15230	COG2205	protein histidine kinase activity
ADEH_RS15235	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ADEH_RS15285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ADEH_RS15290	COG0513	Belongs to the DEAD box helicase family
ADEH_RS15295	COG2205	protein histidine kinase activity
ADEH_RS15295	COG2202	Pas domain
ADEH_RS15305	COG2271	Major facilitator Superfamily
ADEH_RS15315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ADEH_RS15330	COG0484	heat shock protein binding
ADEH_RS15365	COG0577	efflux transmembrane transporter activity
ADEH_RS15365	COG1136	(ABC) transporter
ADEH_RS15370	COG1136	(ABC) transporter
ADEH_RS15370	COG4591	ABC-type transport system involved in lipoprotein release permease component
ADEH_RS15375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ADEH_RS15385	COG1620	l-lactate permease
ADEH_RS15395	COG1139	Iron-sulfur cluster binding protein
ADEH_RS15410	COG4106	trans-aconitate 2-methyltransferase activity
ADEH_RS15430	COG2264	protein methyltransferase activity
ADEH_RS15490	COG4106	trans-aconitate 2-methyltransferase activity
ADEH_RS15495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ADEH_RS15500	COG0745	RESPONSE REGULATOR receiver
ADEH_RS15510	COG3800	Transcriptional regulator
ADEH_RS15510	COG1396	sequence-specific DNA binding
ADEH_RS15515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ADEH_RS15535	COG0366	Alpha amylase catalytic
ADEH_RS15570	COG0318	PFAM AMP-dependent synthetase and ligase
ADEH_RS15585	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADEH_RS15590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADEH_RS15590	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADEH_RS15600	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ADEH_RS15615	COG0277	FAD linked oxidase domain protein
ADEH_RS15620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ADEH_RS15640	COG1960	acyl-CoA dehydrogenase activity
ADEH_RS15655	COG0702	epimerase
ADEH_RS15665	COG3272	Protein of unknown function (DUF1722)
ADEH_RS15675	COG1295	ribonuclease BN
ADEH_RS15680	COG0443	Heat shock 70 kDa protein
ADEH_RS15685	COG0443	Heat shock 70 kDa protein
ADEH_RS15700	COG0667	Aldo Keto reductase
ADEH_RS15705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ADEH_RS15720	COG0667	Aldo Keto reductase
ADEH_RS15725	COG0693	protein deglycase activity
ADEH_RS15765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ADEH_RS15770	COG1216	Glycosyl transferase, family 2
ADEH_RS15775	COG1216	Glycosyl transferase, family 2
ADEH_RS15805	COG0438	transferase activity, transferring glycosyl groups
ADEH_RS15825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ADEH_RS15830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ADEH_RS15920	COG0166	Belongs to the GPI family
ADEH_RS15940	COG0436	Aminotransferase
ADEH_RS15945	COG0840	transmembrane signaling receptor activity
ADEH_RS15950	COG0137	argininosuccinate synthase activity
ADEH_RS15985	COG2204	response regulator
ADEH_RS16005	COG0702	epimerase
ADEH_RS16010	COG0667	Aldo Keto reductase
ADEH_RS16020	COG0308	aminopeptidase N
ADEH_RS16025	COG1309	transcriptional regulator
ADEH_RS16050	COG3608	succinylglutamate desuccinylase aspartoacylase
ADEH_RS16050	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ADEH_RS16065	COG0737	Belongs to the 5'-nucleotidase family
ADEH_RS16070	COG0339	signal peptide processing
ADEH_RS16075	COG3852	Histidine kinase
ADEH_RS16085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ADEH_RS16090	COG1131	(ABC) transporter
ADEH_RS16095	COG1131	(ABC) transporter
ADEH_RS16100	COG0842	Transport permease protein
ADEH_RS16105	COG0842	Transport permease protein
ADEH_RS16110	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ADEH_RS16115	COG2329	Antibiotic biosynthesis monooxygenase
ADEH_RS16120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ADEH_RS16120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ADEH_RS16130	COG3842	ATPase activity
ADEH_RS16135	COG1175	transmembrane transport
ADEH_RS16140	COG0395	ABC-type sugar transport system, permease component
ADEH_RS16170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ADEH_RS16175	COG1595	DNA-templated transcription, initiation
ADEH_RS16180	COG0583	DNA-binding transcription factor activity
ADEH_RS16195	COG1162	GTPase activity
ADEH_RS16215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ADEH_RS16220	COG1127	ABC transporter
ADEH_RS16235	COG1309	transcriptional regulator
ADEH_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS16265	COG0723	plastoquinol--plastocyanin reductase activity
ADEH_RS16295	COG2855	membrane
ADEH_RS16335	COG1028	Short-chain dehydrogenase reductase Sdr
ADEH_RS16365	COG3483	tryptophan 2,3-dioxygenase activity
ADEH_RS16370	COG1064	alcohol dehydrogenase
ADEH_RS16380	COG1131	(ABC) transporter
ADEH_RS16385	COG0025	NhaP-type Na H and K H
ADEH_RS16400	COG2860	membrane
ADEH_RS16405	COG2130	NADP-dependent
ADEH_RS16415	COG1278	Cold shock
ADEH_RS16420	COG0596	Alpha beta hydrolase
ADEH_RS16420	COG0508	dehydrogenase complex catalyzes the overall conversion of
ADEH_RS16430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ADEH_RS16435	COG0784	Response regulator, receiver
ADEH_RS16435	COG2205	protein histidine kinase activity
ADEH_RS16440	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ADEH_RS16455	COG3459	Glycosyltransferase 36 associated
ADEH_RS16475	COG1404	Belongs to the peptidase S8 family
ADEH_RS16505	COG3387	PFAM Glycoside hydrolase 15-related
ADEH_RS16535	COG3604	Transcriptional regulator
ADEH_RS16555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ADEH_RS16560	COG0583	DNA-binding transcription factor activity
ADEH_RS16565	COG4221	oxidoreductase activity
ADEH_RS16570	COG4221	oxidoreductase activity
ADEH_RS16585	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ADEH_RS16595	COG1073	alpha beta
ADEH_RS16600	COG0667	Aldo Keto reductase
ADEH_RS16605	COG0667	Aldo Keto reductase
ADEH_RS16610	COG0702	epimerase
ADEH_RS16615	COG4221	oxidoreductase activity
ADEH_RS16625	COG0583	DNA-binding transcription factor activity
ADEH_RS16640	COG0210	DNA helicase
ADEH_RS16670	COG1196	nuclear chromosome segregation
ADEH_RS16720	COG0358	DNA primase activity
ADEH_RS16820	COG2003	Belongs to the UPF0758 family
ADEH_RS16845	COG0714	Associated with various cellular activities
ADEH_RS16880	COG1192	Involved in chromosome partitioning
ADEH_RS16890	COG0741	lytic transglycosylase activity
ADEH_RS16965	COG0006	proline dipeptidase activity
ADEH_RS16995	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ADEH_RS16995	COG1918	ferrous iron import across plasma membrane
ADEH_RS17000	COG0604	alcohol dehydrogenase
ADEH_RS17025	COG0516	GMP reductase activity
ADEH_RS17030	COG2132	Multicopper oxidase
ADEH_RS17040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ADEH_RS17065	COG1704	LemA family
ADEH_RS17070	COG0501	Belongs to the peptidase M48B family
ADEH_RS17080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ADEH_RS17115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ADEH_RS17135	COG5337	Spore coat protein CotH
ADEH_RS17210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ADEH_RS17245	COG2204	response regulator
ADEH_RS17265	COG5000	phosphorelay sensor kinase activity
ADEH_RS17280	COG2252	PERMEase
ADEH_RS17285	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ADEH_RS17295	COG2136	Putative SAM-dependent methyltransferase
ADEH_RS17295	COG2521	methyltransferase
ADEH_RS17310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ADEH_RS17310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ADEH_RS17325	COG0544	peptidyl-prolyl cis-trans isomerase activity
ADEH_RS17340	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ADEH_RS17350	COG0463	Glycosyl transferase, family 2
ADEH_RS17385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ADEH_RS17390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ADEH_RS17400	COG0709	Synthesizes selenophosphate from selenide and ATP
ADEH_RS17415	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ADEH_RS17435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ADEH_RS17445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ADEH_RS17455	COG0210	DNA helicase
ADEH_RS17485	COG0564	pseudouridine synthase activity
ADEH_RS17490	COG0625	glutathione transferase activity
ADEH_RS17495	COG0612	Peptidase, M16
ADEH_RS17505	COG4191	Histidine kinase
ADEH_RS17515	COG1129	ABC transporter
ADEH_RS17520	COG0739	heme binding
ADEH_RS17525	COG0483	inositol monophosphate 1-phosphatase activity
ADEH_RS17540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ADEH_RS17555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ADEH_RS17565	COG1619	proteins homologs of microcin C7 resistance protein MccF
ADEH_RS17570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ADEH_RS17575	COG0628	permease
ADEH_RS17580	COG0545	Peptidyl-prolyl cis-trans isomerase
ADEH_RS17640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ADEH_RS17645	COG1136	(ABC) transporter
ADEH_RS17650	COG4591	ABC-type transport system involved in lipoprotein release permease component
ADEH_RS17655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ADEH_RS17665	COG0189	ligase activity
ADEH_RS17705	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ADEH_RS17730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ADEH_RS17735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ADEH_RS17740	COG1846	Transcriptional regulator
ADEH_RS17755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ADEH_RS17765	COG0471	metal ion transport
ADEH_RS17765	COG3273	potassium ion transport
ADEH_RS17785	COG0123	including yeast histone deacetylase and acetoin utilization protein
ADEH_RS17820	COG0587	DNA-directed DNA polymerase activity
ADEH_RS17825	COG0730	response to heat
ADEH_RS17835	COG2197	response regulator
ADEH_RS17840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ADEH_RS17860	COG0156	8-amino-7-oxononanoate synthase activity
ADEH_RS17865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ADEH_RS17875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ADEH_RS17885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ADEH_RS17910	COG4206	TonB-dependent receptor
ADEH_RS17920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ADEH_RS17925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ADEH_RS17930	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ADEH_RS17945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ADEH_RS17950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ADEH_RS17965	COG4191	Histidine kinase
ADEH_RS17985	COG2096	Adenosyltransferase
ADEH_RS18000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ADEH_RS18005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ADEH_RS18020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ADEH_RS18040	COG2226	methyltransferase
ADEH_RS18045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ADEH_RS18050	COG1741	Belongs to the pirin family
ADEH_RS18080	COG1937	Protein conserved in bacteria
ADEH_RS18085	COG2217	Heavy metal translocating P-type atpase
ADEH_RS18100	COG4941	Belongs to the sigma-70 factor family
ADEH_RS18105	COG3795	YCII-related domain
ADEH_RS18125	COG0438	transferase activity, transferring glycosyl groups
ADEH_RS18135	COG0667	Aldo Keto reductase
ADEH_RS18140	COG0583	DNA-binding transcription factor activity
ADEH_RS18150	COG3118	belongs to the thioredoxin family
ADEH_RS18180	COG0840	transmembrane signaling receptor activity
ADEH_RS18185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ADEH_RS18205	COG0745	RESPONSE REGULATOR receiver
ADEH_RS18230	COG0330	HflC and HflK could
ADEH_RS18235	COG1404	Belongs to the peptidase S8 family
ADEH_RS18250	COG1063	alcohol dehydrogenase
ADEH_RS18275	COG2205	protein histidine kinase activity
ADEH_RS18325	COG1715	Restriction endonuclease
ADEH_RS18395	COG4974	Belongs to the 'phage' integrase family
ADEH_RS18410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ADEH_RS18420	COG1196	nuclear chromosome segregation
ADEH_RS18420	COG0739	heme binding
ADEH_RS18420	COG0741	lytic transglycosylase activity
ADEH_RS18425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ADEH_RS18435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ADEH_RS18485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ADEH_RS18490	COG1090	epimerase
ADEH_RS18505	COG0750	zinc metalloprotease
ADEH_RS18520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ADEH_RS18565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ADEH_RS18570	COG0459	protein refolding
ADEH_RS18625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ADEH_RS18655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ADEH_RS18660	COG1183	phosphatidylcholine synthase activity
ADEH_RS18665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ADEH_RS18670	COG1546	Belongs to the CinA family
ADEH_RS18670	COG1058	Belongs to the CinA family
ADEH_RS18780	COG1100	Small GTP-binding protein
ADEH_RS18790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ADEH_RS18795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ADEH_RS18800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ADEH_RS18815	COG0590	tRNA wobble adenosine to inosine editing
ADEH_RS18830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ADEH_RS18830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ADEH_RS18840	COG0585	pseudouridine synthase activity
ADEH_RS18895	COG0651	ATP synthesis coupled electron transport
ADEH_RS18900	COG0651	ATP synthesis coupled electron transport
ADEH_RS18915	COG0651	ATP synthesis coupled electron transport
ADEH_RS18920	COG0649	NAD binding
ADEH_RS18925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADEH_RS18945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ADEH_RS18950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ADEH_RS18965	COG0475	glutathione-regulated potassium exporter activity
ADEH_RS18980	COG0739	heme binding
ADEH_RS18990	COG0539	negative regulation of cytoplasmic translation
ADEH_RS19005	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ADEH_RS19025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ADEH_RS19030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ADEH_RS19035	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ADEH_RS19040	COG1428	Deoxynucleoside kinase
ADEH_RS19050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ADEH_RS19060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ADEH_RS19070	COG0484	heat shock protein binding
ADEH_RS19080	COG0631	protein serine/threonine phosphatase activity
ADEH_RS19085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ADEH_RS19105	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ADEH_RS19115	COG0477	Major facilitator Superfamily
ADEH_RS19135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ADEH_RS19140	COG0840	transmembrane signaling receptor activity
ADEH_RS19155	COG0626	cystathionine gamma-synthase activity
ADEH_RS19170	COG0477	Major facilitator Superfamily
ADEH_RS19200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ADEH_RS19210	COG0840	transmembrane signaling receptor activity
ADEH_RS19215	COG1902	pentaerythritol trinitrate reductase activity
ADEH_RS19225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ADEH_RS19230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ADEH_RS19240	COG5002	protein histidine kinase activity
ADEH_RS19245	COG4122	O-methyltransferase activity
ADEH_RS19260	COG3852	Histidine kinase
ADEH_RS19265	COG2204	response regulator
ADEH_RS19270	COG1271	oxidase subunit
ADEH_RS19275	COG1294	oxidase, subunit
ADEH_RS19285	COG2226	methyltransferase
ADEH_RS19320	COG0515	serine threonine protein kinase
ADEH_RS19330	COG1024	Enoyl-CoA hydratase
ADEH_RS19335	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ADEH_RS19360	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ADEH_RS19370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ADEH_RS19385	COG0243	molybdopterin cofactor binding
ADEH_RS19385	COG3383	formate dehydrogenase (NAD+) activity
ADEH_RS19390	COG3383	formate dehydrogenase (NAD+) activity
ADEH_RS19390	COG0243	molybdopterin cofactor binding
ADEH_RS19395	COG0437	4 iron, 4 sulfur cluster binding
ADEH_RS19400	COG2864	formate dehydrogenase
ADEH_RS19435	COG0275	rRNA processing
ADEH_RS19450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ADEH_RS19455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ADEH_RS19465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ADEH_RS19475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ADEH_RS19480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ADEH_RS19485	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ADEH_RS19490	COG1181	Belongs to the D-alanine--D-alanine ligase family
ADEH_RS19510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ADEH_RS19540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ADEH_RS19555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ADEH_RS19565	COG1136	(ABC) transporter
ADEH_RS19565	COG0577	efflux transmembrane transporter activity
ADEH_RS19575	COG1388	LysM domain
ADEH_RS19575	COG1705	Flagellar rod assembly protein muramidase FlgJ
ADEH_RS19585	COG2204	response regulator
ADEH_RS19610	COG0793	Belongs to the peptidase S41A family
ADEH_RS19625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ADEH_RS19665	COG2027	D-alanyl-D-alanine carboxypeptidase
ADEH_RS19690	COG0640	Transcriptional regulator
ADEH_RS19730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ADEH_RS19755	COG2003	Belongs to the UPF0758 family
ADEH_RS19765	COG2353	YceI-like domain
ADEH_RS19775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ADEH_RS19785	COG0436	Aminotransferase
ADEH_RS19810	COG1192	Involved in chromosome partitioning
ADEH_RS19835	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ADEH_RS19840	COG0047	phosphoribosylformylglycinamidine synthase activity
ADEH_RS19860	COG0312	modulator of DNA gyrase
ADEH_RS19865	COG0312	modulator of DNA gyrase
ADEH_RS19880	COG4221	oxidoreductase activity
ADEH_RS19900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ADEH_RS19910	COG2205	protein histidine kinase activity
ADEH_RS19915	COG0745	RESPONSE REGULATOR receiver
ADEH_RS19970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ADEH_RS19995	COG1061	Type III restriction enzyme res subunit
ADEH_RS20040	COG1074	ATP-dependent DNA helicase activity
ADEH_RS20050	COG0653	protein targeting
ADEH_RS20100	COG0745	RESPONSE REGULATOR receiver
ADEH_RS20130	COG0840	transmembrane signaling receptor activity
ADEH_RS20145	COG3321	synthase
ADEH_RS20145	COG0604	alcohol dehydrogenase
ADEH_RS20155	COG2378	regulation of single-species biofilm formation
ADEH_RS20180	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ADEH_RS20195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ADEH_RS20230	COG0488	(ABC) transporter
ADEH_RS20285	COG0154	amidase activity
ADEH_RS20295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ADEH_RS20300	COG0280	phosphate acetyltransferase
ADEH_RS20300	COG0281	malic enzyme
ADEH_RS20315	COG1252	NADH dehydrogenase
ADEH_RS20335	COG0577	efflux transmembrane transporter activity
ADEH_RS20335	COG1136	(ABC) transporter
ADEH_RS20345	COG1136	(ABC) transporter
ADEH_RS20355	COG2840	Smr protein MutS2
ADEH_RS20370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ADEH_RS20375	COG2239	Acts as a magnesium transporter
ADEH_RS20380	COG0284	orotidine-5'-phosphate decarboxylase activity
ADEH_RS20390	COG0442	prolyl-tRNA aminoacylation
ADEH_RS20400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ADEH_RS20405	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ADEH_RS20405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ADEH_RS20410	COG0492	ferredoxin-NADP+ reductase activity
ADEH_RS20440	COG0405	Gamma-glutamyltransferase
ADEH_RS20445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ADEH_RS20450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ADEH_RS20455	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ADEH_RS20470	COG1678	Uncharacterized ACR, COG1678
ADEH_RS20500	COG2379	hydroxypyruvate reductase
ADEH_RS20505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ADEH_RS20515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ADEH_RS20520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ADEH_RS20545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ADEH_RS20565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ADEH_RS20565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ADEH_RS20575	COG0670	Belongs to the BI1 family
ADEH_RS20585	COG0584	glycerophosphoryl diester phosphodiesterase
ADEH_RS20595	COG0488	(ABC) transporter
ADEH_RS20600	COG2814	Major facilitator Superfamily
ADEH_RS20645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ADEH_RS20650	COG3647	Membrane
ADEH_RS20665	COG0704	Plays a role in the regulation of phosphate uptake
ADEH_RS20670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ADEH_RS20675	COG0581	inorganic phosphate transmembrane transporter activity
ADEH_RS20680	COG0573	inorganic phosphate transmembrane transporter activity
ADEH_RS20685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ADEH_RS20695	COG5002	protein histidine kinase activity
ADEH_RS20715	COG0116	Belongs to the methyltransferase superfamily
ADEH_RS20715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ADEH_RS20735	COG2814	Major facilitator Superfamily
ADEH_RS20760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ADEH_RS20765	COG2363	Small membrane protein
ADEH_RS20770	COG2154	pterin-4-alpha-carbinolamine dehydratase
ADEH_RS20780	COG1408	metallophosphoesterase
ADEH_RS20805	COG2967	ApaG domain
ADEH_RS20820	COG0811	peptide transport
ADEH_RS20840	COG2030	dehydratase
ADEH_RS20850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ADEH_RS20870	COG0574	Belongs to the PEP-utilizing enzyme family
ADEH_RS20870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ADEH_RS20875	COG0301	tRNA thio-modification
ADEH_RS20880	COG0425	Belongs to the sulfur carrier protein TusA family
ADEH_RS20895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ADEH_RS20895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ADEH_RS20905	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ADEH_RS20910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ADEH_RS20920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ADEH_RS20925	COG0134	indole-3-glycerol-phosphate synthase activity
ADEH_RS20930	COG0135	phosphoribosylanthranilate isomerase activity
ADEH_RS20935	COG0133	tryptophan synthase activity
ADEH_RS20940	COG0159	tryptophan synthase activity
ADEH_RS20950	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ADEH_RS20980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ADEH_RS20985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ADEH_RS20985	COG0517	IMP dehydrogenase activity
ADEH_RS20990	COG0235	Class ii aldolase
ADEH_RS21000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ADEH_RS21005	COG0179	Fumarylacetoacetate (FAA) hydrolase
ADEH_RS21010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ADEH_RS21015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ADEH_RS21020	COG0019	diaminopimelate decarboxylase activity
ADEH_RS21030	COG0165	Argininosuccinate lyase
ADEH_RS21045	COG0346	lactoylglutathione lyase activity
ADEH_RS21055	COG2715	membrane protein required for spore maturation
ADEH_RS21060	COG0700	Nucleoside recognition
ADEH_RS21105	COG0297	glycogen (starch) synthase activity
ADEH_RS21150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ADEH_RS21155	COG0438	transferase activity, transferring glycosyl groups
ADEH_RS21165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ADEH_RS21175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ADEH_RS21195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ADEH_RS21200	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ADEH_RS21205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ADEH_RS21235	COG0129	dihydroxy-acid dehydratase activity
ADEH_RS21265	COG0745	RESPONSE REGULATOR receiver
ADEH_RS21280	COG1960	acyl-CoA dehydrogenase activity
ADEH_RS21300	COG2198	Histidine kinase
ADEH_RS21300	COG5002	protein histidine kinase activity
ADEH_RS21300	COG0784	Response regulator, receiver
ADEH_RS21350	COG4580	involved in the transport of maltose and maltodextrins
ADEH_RS21360	COG0395	ABC-type sugar transport system, permease component
ADEH_RS21365	COG1175	transmembrane transport
ADEH_RS21380	COG0366	Alpha amylase catalytic
ADEH_RS21425	COG0438	transferase activity, transferring glycosyl groups
ADEH_RS21430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ADEH_RS21460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ADEH_RS21465	COG0577	efflux transmembrane transporter activity
ADEH_RS21465	COG1136	(ABC) transporter
ADEH_RS21470	COG0577	efflux transmembrane transporter activity
ADEH_RS21470	COG1136	(ABC) transporter
ADEH_RS21475	COG0577	efflux transmembrane transporter activity
ADEH_RS21475	COG1136	(ABC) transporter
ADEH_RS21480	COG0681	Belongs to the peptidase S26 family
ADEH_RS21490	COG1793	dna ligase
ADEH_RS21500	COG3259	Nickel-dependent hydrogenase
ADEH_RS21520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ADEH_RS21525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ADEH_RS21550	COG1560	Kdo2-lipid A biosynthetic process
ADEH_RS21555	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ADEH_RS21560	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ADEH_RS21565	COG0504	CTP synthase activity
ADEH_RS21570	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ADEH_RS21580	COG0564	pseudouridine synthase activity
ADEH_RS21590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ADEH_RS21595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ADEH_RS21605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ADEH_RS21615	COG3339	Conserved Protein
ADEH_RS21625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ADEH_RS21635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ADEH_RS21640	COG0154	amidase activity
ADEH_RS21645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ADEH_RS21655	COG0457	Tetratricopeptide repeat
ADEH_RS21660	COG1674	ftsk spoiiie
ADEH_RS21670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ADEH_RS21685	COG0713	ATP synthesis coupled electron transport
ADEH_RS21690	COG0839	Belongs to the complex I subunit 6 family
ADEH_RS21730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ADEH_RS21765	COG0784	Response regulator, receiver
ADEH_RS21765	COG2205	protein histidine kinase activity
ADEH_RS21770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ADEH_RS21800	COG1193	negative regulation of DNA recombination
ADEH_RS21805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ADEH_RS21835	COG5002	protein histidine kinase activity
ADEH_RS21845	COG0306	phosphate transporter
ADEH_RS21850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ADEH_RS21860	COG2094	Belongs to the DNA glycosylase MPG family
ADEH_RS21885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ADEH_RS21905	COG2204	response regulator
ADEH_RS21915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ADEH_RS21935	COG3852	Histidine kinase
ADEH_RS21950	COG3852	Histidine kinase
ADEH_RS21965	COG0174	glutamine synthetase
ADEH_RS21995	COG0411	ABC transporter
ADEH_RS22005	COG0559	Belongs to the binding-protein-dependent transport system permease family
ADEH_RS22015	COG0745	RESPONSE REGULATOR receiver
ADEH_RS22030	COG1472	Belongs to the glycosyl hydrolase 3 family
ADEH_RS22045	COG2827	Endonuclease containing a URI domain
ADEH_RS22050	COG0714	Associated with various cellular activities
ADEH_RS22085	COG1596	polysaccharide export
ADEH_RS22095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ADEH_RS22130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ADEH_RS22135	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ADEH_RS22165	COG0463	Glycosyl transferase, family 2
ADEH_RS22185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ADEH_RS22190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ADEH_RS22210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ADEH_RS22235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ADEH_RS22240	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ADEH_RS22265	COG3852	Histidine kinase
ADEH_RS22270	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ADEH_RS22275	COG1691	(AIR) carboxylase
ADEH_RS22285	COG2198	Histidine kinase
ADEH_RS22285	COG0643	Histidine kinase
ADEH_RS22290	COG2201	protein-glutamate methylesterase activity
ADEH_RS22300	COG3290	protein histidine kinase activity
ADEH_RS22300	COG0840	transmembrane signaling receptor activity
ADEH_RS22305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ADEH_RS22310	COG2205	protein histidine kinase activity
ADEH_RS22310	COG2202	Pas domain
ADEH_RS22315	COG1100	Small GTP-binding protein
ADEH_RS22320	COG1199	ATP-dependent helicase activity
ADEH_RS22340	COG0484	heat shock protein binding
ADEH_RS22345	COG0443	Heat shock 70 kDa protein
ADEH_RS22350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ADEH_RS22355	COG1420	regulation of RNA biosynthetic process
ADEH_RS22375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ADEH_RS22380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ADEH_RS22385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ADEH_RS22390	COG0012	GTP binding
ADEH_RS22395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ADEH_RS22400	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ADEH_RS22405	COG0356	it plays a direct role in the translocation of protons across the membrane
ADEH_RS22425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ADEH_RS22440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ADEH_RS22445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ADEH_RS22450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ADEH_RS22455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ADEH_RS22460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ADEH_RS22465	COG0071	Belongs to the small heat shock protein (HSP20) family
ADEH_RS22475	COG1475	DNA binding
ADEH_RS22480	COG1192	Involved in chromosome partitioning
ADEH_RS22485	COG0357	Ribosomal RNA small subunit methyltransferase G
ADEH_RS22500	COG0706	membrane insertase activity
ADEH_RS22505	COG0594	ribonuclease P activity
ADEH_RS22525	COG2151	metal-sulfur cluster biosynthetic enzyme
ADEH_RS22530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ADEH_RS22540	COG0840	transmembrane signaling receptor activity
ADEH_RS22575	COG0515	serine threonine protein kinase
ADEH_RS22590	COG2801	Transposase and inactivated derivatives
ADEH_RS22615	COG1475	DNA binding
ADEH_RS22630	COG5002	protein histidine kinase activity
ADEH_RS22630	COG5001	Diguanylate cyclase
ADEH_RS22630	COG3447	MASE1 domain protein