locus-tag	class	description
ANAE109_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ANAE109_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ANAE109_RS00025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ANAE109_RS00045	COG0596	Alpha beta hydrolase
ANAE109_RS00050	COG0247	lactate metabolic process
ANAE109_RS00050	COG2181	nitrate reductase activity
ANAE109_RS00065	COG0189	ligase activity
ANAE109_RS00070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ANAE109_RS00075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ANAE109_RS00080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ANAE109_RS00105	COG3047	cAMP biosynthetic process
ANAE109_RS00105	COG2885	chlorophyll binding
ANAE109_RS00165	COG0477	Major facilitator Superfamily
ANAE109_RS00170	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS00185	COG2067	long-chain fatty acid transport protein
ANAE109_RS00190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ANAE109_RS00205	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ANAE109_RS00215	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ANAE109_RS00230	COG0280	phosphate acetyltransferase
ANAE109_RS00235	COG3426	butyrate kinase activity
ANAE109_RS00255	COG2086	electron transfer activity
ANAE109_RS00265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANAE109_RS00270	COG0861	Integral membrane protein TerC family
ANAE109_RS00280	COG0297	glycogen (starch) synthase activity
ANAE109_RS00285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ANAE109_RS00290	COG2233	PERMEase
ANAE109_RS00295	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ANAE109_RS00295	COG1793	dna ligase
ANAE109_RS00300	COG4122	O-methyltransferase activity
ANAE109_RS00305	COG0564	pseudouridine synthase activity
ANAE109_RS00325	COG0805	protein transport
ANAE109_RS00335	COG0183	Belongs to the thiolase family
ANAE109_RS00365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ANAE109_RS00370	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ANAE109_RS00385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANAE109_RS00395	COG0352	thiamine-phosphate diphosphorylase activity
ANAE109_RS00400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ANAE109_RS00405	COG0352	thiamine-phosphate diphosphorylase activity
ANAE109_RS00405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ANAE109_RS00405	COG0351	phosphomethylpyrimidine kinase
ANAE109_RS00410	COG0305	Participates in initiation and elongation during chromosome replication
ANAE109_RS00420	COG2239	Acts as a magnesium transporter
ANAE109_RS00425	COG0612	Peptidase, M16
ANAE109_RS00455	COG1410	methionine synthase
ANAE109_RS00455	COG0646	methionine synthase
ANAE109_RS00475	COG0433	COG0433 Predicted ATPase
ANAE109_RS00480	COG0463	Glycosyl transferase, family 2
ANAE109_RS00490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANAE109_RS00495	COG1666	GTP binding
ANAE109_RS00500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ANAE109_RS00510	COG0210	DNA helicase
ANAE109_RS00520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ANAE109_RS00525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ANAE109_RS00540	COG0612	Peptidase, M16
ANAE109_RS00545	COG0612	Peptidase, M16
ANAE109_RS00570	COG2204	response regulator
ANAE109_RS00575	COG3852	Histidine kinase
ANAE109_RS00605	COG1077	Cell shape determining protein MreB Mrl
ANAE109_RS00610	COG1506	peptidase
ANAE109_RS00610	COG0823	Involved in the tonB-independent uptake of proteins
ANAE109_RS00620	COG0359	binds to the 23S rRNA
ANAE109_RS00625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ANAE109_RS00630	COG0360	Binds together with S18 to 16S ribosomal RNA
ANAE109_RS00635	COG0193	aminoacyl-tRNA hydrolase activity
ANAE109_RS00640	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ANAE109_RS00645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ANAE109_RS00650	COG2088	sporulation resulting in formation of a cellular spore
ANAE109_RS00655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ANAE109_RS00670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ANAE109_RS00675	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ANAE109_RS00715	COG0297	glycogen (starch) synthase activity
ANAE109_RS00735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ANAE109_RS00735	COG2022	thiamine diphosphate biosynthetic process
ANAE109_RS00745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ANAE109_RS00765	COG2204	response regulator
ANAE109_RS00775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ANAE109_RS00780	COG1660	Displays ATPase and GTPase activities
ANAE109_RS00785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ANAE109_RS00785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ANAE109_RS00800	COG3716	PTS system mannose fructose sorbose family IID component
ANAE109_RS00810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANAE109_RS00815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ANAE109_RS00820	COG2226	methyltransferase
ANAE109_RS00825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ANAE109_RS00835	COG1968	undecaprenyl-diphosphatase activity
ANAE109_RS00845	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ANAE109_RS00845	COG0662	Cupin 2, conserved barrel domain protein
ANAE109_RS00855	COG1940	carbohydrate kinase activity
ANAE109_RS00875	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ANAE109_RS00920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ANAE109_RS00925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ANAE109_RS00930	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANAE109_RS00955	COG0577	efflux transmembrane transporter activity
ANAE109_RS00975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ANAE109_RS00995	COG3138	arginine N-succinyltransferase
ANAE109_RS01000	COG1490	D-aminoacyl-tRNA deacylase activity
ANAE109_RS01005	COG0537	adenosine 5'-monophosphoramidase activity
ANAE109_RS01030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANAE109_RS01035	COG0287	Prephenate dehydrogenase
ANAE109_RS01040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ANAE109_RS01045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ANAE109_RS01050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ANAE109_RS01055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ANAE109_RS01060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ANAE109_RS01065	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ANAE109_RS01070	COG0463	Glycosyl transferase, family 2
ANAE109_RS01120	COG0546	phosphoglycolate phosphatase activity
ANAE109_RS01125	COG2814	Major facilitator Superfamily
ANAE109_RS01150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ANAE109_RS01155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ANAE109_RS01160	COG0799	negative regulation of ribosome biogenesis
ANAE109_RS01170	COG0697	spore germination
ANAE109_RS01200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ANAE109_RS01200	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANAE109_RS01200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANAE109_RS01200	COG1013	pyruvate-flavodoxin oxidoreductase activity
ANAE109_RS01220	COG0493	'glutamate synthase
ANAE109_RS01270	COG1595	DNA-templated transcription, initiation
ANAE109_RS01280	COG0534	Mate efflux family protein
ANAE109_RS01290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ANAE109_RS01310	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ANAE109_RS01315	COG1040	competence protein
ANAE109_RS01350	COG1297	OPT oligopeptide transporter protein
ANAE109_RS01360	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS01365	COG2264	protein methyltransferase activity
ANAE109_RS01370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ANAE109_RS01385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ANAE109_RS01395	COG1278	Cold shock
ANAE109_RS01410	COG0204	Acyl-transferase
ANAE109_RS01420	COG2205	protein histidine kinase activity
ANAE109_RS01425	COG4770	biotin carboxylase activity
ANAE109_RS01430	COG0511	ligase activity, forming carbon-carbon bonds
ANAE109_RS01430	COG5016	pyruvate
ANAE109_RS01435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS01435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS01440	COG0484	heat shock protein binding
ANAE109_RS01465	COG0564	pseudouridine synthase activity
ANAE109_RS01470	COG0848	biopolymer transport protein
ANAE109_RS01500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ANAE109_RS01505	COG0052	Belongs to the universal ribosomal protein uS2 family
ANAE109_RS01520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANAE109_RS01520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ANAE109_RS01525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANAE109_RS01535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ANAE109_RS01540	COG0617	tRNA 3'-terminal CCA addition
ANAE109_RS01545	COG0528	UMP kinase activity
ANAE109_RS01550	COG0233	cytoplasmic translational termination
ANAE109_RS01560	COG3360	Dodecin
ANAE109_RS01570	COG2326	polyphosphate kinase activity
ANAE109_RS01580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ANAE109_RS01580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANAE109_RS01615	COG1640	4-alpha-glucanotransferase
ANAE109_RS01620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANAE109_RS01635	COG1063	alcohol dehydrogenase
ANAE109_RS01640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ANAE109_RS01660	COG0010	Belongs to the arginase family
ANAE109_RS01665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ANAE109_RS01675	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS01680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ANAE109_RS01760	COG0700	Nucleoside recognition
ANAE109_RS01765	COG2715	membrane protein required for spore maturation
ANAE109_RS01775	COG0346	lactoylglutathione lyase activity
ANAE109_RS01790	COG0165	Argininosuccinate lyase
ANAE109_RS01795	COG0019	diaminopimelate decarboxylase activity
ANAE109_RS01800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ANAE109_RS01805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ANAE109_RS01810	COG0179	Fumarylacetoacetate (FAA) hydrolase
ANAE109_RS01815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ANAE109_RS01835	COG3647	Membrane
ANAE109_RS01840	COG0235	Class ii aldolase
ANAE109_RS01845	COG0517	IMP dehydrogenase activity
ANAE109_RS01845	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ANAE109_RS01850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANAE109_RS01870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANAE109_RS01875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ANAE109_RS01885	COG0159	tryptophan synthase activity
ANAE109_RS01890	COG0133	tryptophan synthase activity
ANAE109_RS01895	COG0135	phosphoribosylanthranilate isomerase activity
ANAE109_RS01900	COG0134	indole-3-glycerol-phosphate synthase activity
ANAE109_RS01905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ANAE109_RS01910	COG0512	Glutamine amidotransferase of anthranilate synthase
ANAE109_RS01920	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ANAE109_RS01935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ANAE109_RS01935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANAE109_RS01955	COG0482	sulfurtransferase activity
ANAE109_RS01960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ANAE109_RS01960	COG0574	Belongs to the PEP-utilizing enzyme family
ANAE109_RS01975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANAE109_RS01985	COG2030	dehydratase
ANAE109_RS02005	COG0811	peptide transport
ANAE109_RS02015	COG2967	ApaG domain
ANAE109_RS02020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ANAE109_RS02030	COG1408	metallophosphoesterase
ANAE109_RS02040	COG2154	pterin-4-alpha-carbinolamine dehydratase
ANAE109_RS02045	COG2363	Small membrane protein
ANAE109_RS02050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANAE109_RS02065	COG1201	RNA secondary structure unwinding
ANAE109_RS02095	COG0116	Belongs to the methyltransferase superfamily
ANAE109_RS02095	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ANAE109_RS02115	COG5002	protein histidine kinase activity
ANAE109_RS02130	COG0573	inorganic phosphate transmembrane transporter activity
ANAE109_RS02135	COG0581	inorganic phosphate transmembrane transporter activity
ANAE109_RS02140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ANAE109_RS02145	COG0704	Plays a role in the regulation of phosphate uptake
ANAE109_RS02210	COG0488	(ABC) transporter
ANAE109_RS02220	COG0584	glycerophosphoryl diester phosphodiesterase
ANAE109_RS02255	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS02265	COG1573	uracil-dna glycosylase
ANAE109_RS02280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ANAE109_RS02310	COG2379	hydroxypyruvate reductase
ANAE109_RS02335	COG1678	Uncharacterized ACR, COG1678
ANAE109_RS02345	COG1796	DNA polymerase
ANAE109_RS02345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ANAE109_RS02360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ANAE109_RS02365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ANAE109_RS02370	COG0405	Gamma-glutamyltransferase
ANAE109_RS02400	COG2201	protein-glutamate methylesterase activity
ANAE109_RS02415	COG0492	ferredoxin-NADP+ reductase activity
ANAE109_RS02420	COG4106	trans-aconitate 2-methyltransferase activity
ANAE109_RS02425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ANAE109_RS02425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANAE109_RS02430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ANAE109_RS02440	COG0442	prolyl-tRNA aminoacylation
ANAE109_RS02455	COG0596	Alpha beta hydrolase
ANAE109_RS02460	COG0450	alkyl hydroperoxide reductase
ANAE109_RS02470	COG0640	Transcriptional regulator
ANAE109_RS02475	COG1819	glycosyl
ANAE109_RS02515	COG2840	Smr protein MutS2
ANAE109_RS02525	COG1136	(ABC) transporter
ANAE109_RS02535	COG0577	efflux transmembrane transporter activity
ANAE109_RS02535	COG1136	(ABC) transporter
ANAE109_RS02555	COG2132	Multicopper oxidase
ANAE109_RS02560	COG0280	phosphate acetyltransferase
ANAE109_RS02560	COG0281	malic enzyme
ANAE109_RS02575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANAE109_RS02580	COG2204	response regulator
ANAE109_RS02590	COG0154	amidase activity
ANAE109_RS02600	COG3875	lactate racemase activity
ANAE109_RS02615	COG0640	Transcriptional regulator
ANAE109_RS02635	COG0409	Hydrogenase expression formation protein
ANAE109_RS02640	COG0298	carbon dioxide binding
ANAE109_RS02645	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ANAE109_RS02665	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ANAE109_RS02670	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ANAE109_RS02675	COG5557	Pfam Polysulphide reductase, NrfD
ANAE109_RS02680	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS02685	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ANAE109_RS02690	COG1322	Protein conserved in bacteria
ANAE109_RS02710	COG1285	pathogenesis
ANAE109_RS02725	COG2119	membrane
ANAE109_RS02755	COG0784	Response regulator, receiver
ANAE109_RS02755	COG2205	protein histidine kinase activity
ANAE109_RS02765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ANAE109_RS02785	COG1612	heme a metabolic process
ANAE109_RS02785	COG0109	protoheme IX farnesyltransferase activity
ANAE109_RS02790	COG2885	chlorophyll binding
ANAE109_RS02810	COG0667	Aldo Keto reductase
ANAE109_RS02820	COG3181	Tripartite tricarboxylate transporter family receptor
ANAE109_RS02850	COG2814	Major facilitator Superfamily
ANAE109_RS02855	COG2259	Doxx family
ANAE109_RS02865	COG1063	alcohol dehydrogenase
ANAE109_RS02880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANAE109_RS02920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ANAE109_RS02925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ANAE109_RS02980	COG0723	plastoquinol--plastocyanin reductase activity
ANAE109_RS03045	COG3265	gluconokinase activity
ANAE109_RS03050	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ANAE109_RS03060	COG0406	alpha-ribazole phosphatase activity
ANAE109_RS03065	COG0363	glucosamine-6-phosphate deaminase activity
ANAE109_RS03070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ANAE109_RS03075	COG3604	Transcriptional regulator
ANAE109_RS03080	COG0640	Transcriptional regulator
ANAE109_RS03105	COG3177	Filamentation induced by cAMP protein fic
ANAE109_RS03130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANAE109_RS03140	COG0402	S-adenosylhomocysteine deaminase activity
ANAE109_RS03145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ANAE109_RS03150	COG2204	response regulator
ANAE109_RS03155	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS03175	COG0612	Peptidase, M16
ANAE109_RS03180	COG3852	Histidine kinase
ANAE109_RS03205	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS03235	COG0542	response to heat
ANAE109_RS03240	COG1438	arginine binding
ANAE109_RS03245	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ANAE109_RS03250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ANAE109_RS03270	COG4232	protein-disulfide reductase activity
ANAE109_RS03275	COG1104	cysteine desulfurase activity
ANAE109_RS03285	COG0316	Belongs to the HesB IscA family
ANAE109_RS03290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ANAE109_RS03295	COG0443	Heat shock 70 kDa protein
ANAE109_RS03300	COG0633	Ferredoxin
ANAE109_RS03305	COG2975	iron-sulfur cluster assembly
ANAE109_RS03310	COG2201	protein-glutamate methylesterase activity
ANAE109_RS03320	COG0835	chemotaxis
ANAE109_RS03325	COG2198	Histidine kinase
ANAE109_RS03325	COG0643	Histidine kinase
ANAE109_RS03330	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ANAE109_RS03340	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS03355	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS03380	COG2201	protein-glutamate methylesterase activity
ANAE109_RS03390	COG0784	Response regulator, receiver
ANAE109_RS03395	COG0217	transcriptional regulatory protein
ANAE109_RS03415	COG0295	cytidine deaminase activity
ANAE109_RS03420	COG0196	riboflavin kinase activity
ANAE109_RS03425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ANAE109_RS03435	COG1459	type II secretion system
ANAE109_RS03440	COG4191	Histidine kinase
ANAE109_RS03495	COG1131	(ABC) transporter
ANAE109_RS03500	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ANAE109_RS03505	COG4191	Histidine kinase
ANAE109_RS03510	COG2204	response regulator
ANAE109_RS03555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ANAE109_RS03565	COG0439	Biotin carboxylase
ANAE109_RS03575	COG3267	Type II secretory pathway component ExeA
ANAE109_RS03575	COG3409	Peptidoglycan-binding domain 1 protein
ANAE109_RS03590	COG2217	Heavy metal translocating P-type atpase
ANAE109_RS03595	COG2226	methyltransferase
ANAE109_RS03600	COG0248	Ppx GppA phosphatase
ANAE109_RS03630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ANAE109_RS03640	COG2884	Cell division ATP-binding protein ftsE
ANAE109_RS03645	COG2177	Part of the ABC transporter FtsEX involved in
ANAE109_RS03650	COG4942	peptidase
ANAE109_RS03655	COG0793	Belongs to the peptidase S41A family
ANAE109_RS03660	COG1215	transferase activity, transferring glycosyl groups
ANAE109_RS03670	COG1215	transferase activity, transferring glycosyl groups
ANAE109_RS03675	COG0546	phosphoglycolate phosphatase activity
ANAE109_RS03680	COG0552	protein localization to endoplasmic reticulum
ANAE109_RS03685	COG1196	nuclear chromosome segregation
ANAE109_RS03730	COG1459	type II secretion system
ANAE109_RS03735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ANAE109_RS03750	COG2204	response regulator
ANAE109_RS03755	COG0254	rRNA binding
ANAE109_RS03760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ANAE109_RS03765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ANAE109_RS03770	COG1254	Belongs to the acylphosphatase family
ANAE109_RS03780	COG1530	ribonuclease E activity
ANAE109_RS03785	COG1295	ribonuclease BN
ANAE109_RS03790	COG0776	regulation of translation
ANAE109_RS03795	COG4789	Type iii secretion
ANAE109_RS03825	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ANAE109_RS03860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ANAE109_RS03865	COG0131	Imidazoleglycerol-phosphate dehydratase
ANAE109_RS03870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ANAE109_RS03875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ANAE109_RS03880	COG0107	imidazoleglycerol-phosphate synthase activity
ANAE109_RS03890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ANAE109_RS03925	COG0730	response to heat
ANAE109_RS03930	COG0446	pyridine nucleotide-disulphide oxidoreductase
ANAE109_RS03940	COG0242	peptide deformylase activity
ANAE109_RS03950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ANAE109_RS03970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ANAE109_RS03975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ANAE109_RS03985	COG0497	DNA recombination
ANAE109_RS03990	COG0631	protein serine/threonine phosphatase activity
ANAE109_RS03995	COG0739	heme binding
ANAE109_RS04005	COG0653	protein targeting
ANAE109_RS04030	COG0628	permease
ANAE109_RS04040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ANAE109_RS04045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ANAE109_RS04050	COG0739	heme binding
ANAE109_RS04055	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ANAE109_RS04060	COG1846	Transcriptional regulator
ANAE109_RS04090	COG0348	domain, Protein
ANAE109_RS04095	COG1366	Belongs to the anti-sigma-factor antagonist family
ANAE109_RS04100	COG1366	Belongs to the anti-sigma-factor antagonist family
ANAE109_RS04105	COG2172	sigma factor antagonist activity
ANAE109_RS04115	COG0784	Response regulator, receiver
ANAE109_RS04115	COG2205	protein histidine kinase activity
ANAE109_RS04115	COG5002	protein histidine kinase activity
ANAE109_RS04120	COG2205	protein histidine kinase activity
ANAE109_RS04125	COG2962	Rard protein
ANAE109_RS04130	COG0589	response to stress
ANAE109_RS04140	COG0167	dihydroorotate dehydrogenase activity
ANAE109_RS04155	COG1592	Rubrerythrin
ANAE109_RS04175	COG0693	protein deglycase activity
ANAE109_RS04195	COG0529	Catalyzes the synthesis of activated sulfate
ANAE109_RS04205	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ANAE109_RS04225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANAE109_RS04230	COG1253	flavin adenine dinucleotide binding
ANAE109_RS04240	COG2890	protein-(glutamine-N5) methyltransferase activity
ANAE109_RS04250	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANAE109_RS04265	COG1643	Atp-dependent helicase
ANAE109_RS04280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ANAE109_RS04285	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ANAE109_RS04295	COG1595	DNA-templated transcription, initiation
ANAE109_RS04305	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS04340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ANAE109_RS04370	COG0069	glutamate synthase activity
ANAE109_RS04370	COG0067	glutamate synthase
ANAE109_RS04370	COG0070	glutamate synthase
ANAE109_RS04375	COG0493	'glutamate synthase
ANAE109_RS04395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANAE109_RS04405	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS04410	COG0243	molybdopterin cofactor binding
ANAE109_RS04410	COG3383	formate dehydrogenase (NAD+) activity
ANAE109_RS04420	COG3973	AAA domain
ANAE109_RS04425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ANAE109_RS04465	COG0811	peptide transport
ANAE109_RS04490	COG0488	(ABC) transporter
ANAE109_RS04500	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS04505	COG2205	protein histidine kinase activity
ANAE109_RS04520	COG1309	transcriptional regulator
ANAE109_RS04525	COG0300	oxidoreductase activity
ANAE109_RS04535	COG1012	belongs to the aldehyde dehydrogenase family
ANAE109_RS04550	COG3852	Histidine kinase
ANAE109_RS04560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANAE109_RS04565	COG1131	(ABC) transporter
ANAE109_RS04570	COG1131	(ABC) transporter
ANAE109_RS04575	COG0842	Transport permease protein
ANAE109_RS04580	COG0842	Transport permease protein
ANAE109_RS04585	COG1131	(ABC) transporter
ANAE109_RS04590	COG0842	Transport permease protein
ANAE109_RS04600	COG0514	ATP-dependent DNA helicase (RecQ)
ANAE109_RS04605	COG4681	YaeQ
ANAE109_RS04615	COG0719	Fe-S assembly protein
ANAE109_RS04620	COG0396	ATPase activity
ANAE109_RS04625	COG0719	Fe-S assembly protein
ANAE109_RS04630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ANAE109_RS04635	COG0822	iron-sulfur transferase activity
ANAE109_RS04660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANAE109_RS04665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANAE109_RS04670	COG2197	response regulator
ANAE109_RS04700	COG0058	SHG alpha-glucan phosphorylase activity
ANAE109_RS04710	COG1704	LemA family
ANAE109_RS04735	COG1396	sequence-specific DNA binding
ANAE109_RS04740	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS04780	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ANAE109_RS04800	COG0668	transmembrane transport
ANAE109_RS04820	COG2322	membrane
ANAE109_RS04835	COG0109	protoheme IX farnesyltransferase activity
ANAE109_RS04850	COG0037	tRNA processing
ANAE109_RS04855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ANAE109_RS04860	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ANAE109_RS04870	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ANAE109_RS04885	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ANAE109_RS04890	COG3005	denitrification pathway
ANAE109_RS04935	COG2204	response regulator
ANAE109_RS04940	COG4191	Histidine kinase
ANAE109_RS04945	COG2873	o-acetylhomoserine
ANAE109_RS04960	COG0432	Pfam Uncharacterised protein family UPF0047
ANAE109_RS04980	COG1192	Involved in chromosome partitioning
ANAE109_RS04985	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ANAE109_RS05000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANAE109_RS05005	COG0584	glycerophosphoryl diester phosphodiesterase
ANAE109_RS05020	COG1271	oxidase subunit
ANAE109_RS05025	COG1294	oxidase, subunit
ANAE109_RS05035	COG1331	Highly conserved protein containing a thioredoxin domain
ANAE109_RS05060	COG3158	transport of potassium into the cell
ANAE109_RS05065	COG2814	Major facilitator Superfamily
ANAE109_RS05070	COG2814	Major facilitator Superfamily
ANAE109_RS05075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ANAE109_RS05080	COG0632	four-way junction helicase activity
ANAE109_RS05095	COG2255	four-way junction helicase activity
ANAE109_RS05110	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ANAE109_RS05140	COG3285	dna ligase
ANAE109_RS05140	COG1793	dna ligase
ANAE109_RS05160	COG0427	acetyl-CoA hydrolase
ANAE109_RS05195	COG2204	response regulator
ANAE109_RS05225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANAE109_RS05230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANAE109_RS05245	COG4191	Histidine kinase
ANAE109_RS05250	COG1368	sulfuric ester hydrolase activity
ANAE109_RS05260	COG2133	pyrroloquinoline quinone binding
ANAE109_RS05275	COG2205	protein histidine kinase activity
ANAE109_RS05305	COG1309	transcriptional regulator
ANAE109_RS05310	COG3850	Histidine kinase
ANAE109_RS05310	COG5002	protein histidine kinase activity
ANAE109_RS05315	COG0569	domain protein
ANAE109_RS05325	COG0577	efflux transmembrane transporter activity
ANAE109_RS05325	COG1136	(ABC) transporter
ANAE109_RS05340	COG1309	transcriptional regulator
ANAE109_RS05360	COG1252	NADH dehydrogenase
ANAE109_RS05375	COG0543	2 iron, 2 sulfur cluster binding
ANAE109_RS05375	COG0633	Ferredoxin
ANAE109_RS05380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ANAE109_RS05390	COG0596	Alpha beta hydrolase
ANAE109_RS05420	COG0640	Transcriptional regulator
ANAE109_RS05475	COG3328	transposase activity
ANAE109_RS05515	COG1715	Restriction endonuclease
ANAE109_RS05540	COG1335	isochorismatase
ANAE109_RS05550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANAE109_RS05555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ANAE109_RS05565	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ANAE109_RS05570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ANAE109_RS05575	COG1692	metallophosphoesterase
ANAE109_RS05585	COG0515	serine threonine protein kinase
ANAE109_RS05590	COG1104	cysteine desulfurase activity
ANAE109_RS05600	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ANAE109_RS05620	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ANAE109_RS05625	COG2204	response regulator
ANAE109_RS05640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANAE109_RS05645	COG4221	oxidoreductase activity
ANAE109_RS05650	COG5000	phosphorelay sensor kinase activity
ANAE109_RS05675	COG1543	Belongs to the glycosyl hydrolase 57 family
ANAE109_RS05685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ANAE109_RS05695	COG1136	(ABC) transporter
ANAE109_RS05700	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ANAE109_RS05710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANAE109_RS05715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ANAE109_RS05720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANAE109_RS05725	COG3494	Protein of unknown function (DUF1009)
ANAE109_RS05730	COG1872	DUF167
ANAE109_RS05740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ANAE109_RS05745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ANAE109_RS05750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ANAE109_RS05760	COG1570	exodeoxyribonuclease VII activity
ANAE109_RS05765	COG1722	exodeoxyribonuclease VII activity
ANAE109_RS05770	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS05775	COG0142	geranyltranstransferase activity
ANAE109_RS05780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ANAE109_RS05785	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ANAE109_RS05790	COG0779	Required for maturation of 30S ribosomal subunits
ANAE109_RS05800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ANAE109_RS05810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ANAE109_RS05815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ANAE109_RS05820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ANAE109_RS05825	COG1185	polyribonucleotide nucleotidyltransferase activity
ANAE109_RS05830	COG0756	dUTP diphosphatase activity
ANAE109_RS05835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ANAE109_RS05865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANAE109_RS05885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ANAE109_RS05895	COG0314	molybdopterin synthase activity
ANAE109_RS05900	COG0750	zinc metalloprotease
ANAE109_RS05905	COG2078	PFAM AMMECR1 domain protein
ANAE109_RS05905	COG3885	ferrous iron binding
ANAE109_RS05910	COG2816	NAD+ diphosphatase activity
ANAE109_RS05930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANAE109_RS05940	COG1164	Oligoendopeptidase f
ANAE109_RS05965	COG0559	Belongs to the binding-protein-dependent transport system permease family
ANAE109_RS05995	COG1324	tolerance protein
ANAE109_RS06010	COG0515	serine threonine protein kinase
ANAE109_RS06020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ANAE109_RS06025	COG0616	signal peptide processing
ANAE109_RS06030	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ANAE109_RS06050	COG1408	metallophosphoesterase
ANAE109_RS06070	COG0450	alkyl hydroperoxide reductase
ANAE109_RS06075	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ANAE109_RS06100	COG1100	Small GTP-binding protein
ANAE109_RS06110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ANAE109_RS06160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANAE109_RS06165	COG0318	PFAM AMP-dependent synthetase and ligase
ANAE109_RS06170	COG3875	lactate racemase activity
ANAE109_RS06190	COG0243	molybdopterin cofactor binding
ANAE109_RS06195	COG3278	Belongs to the heme-copper respiratory oxidase family
ANAE109_RS06210	COG0348	domain, Protein
ANAE109_RS06225	COG2217	Heavy metal translocating P-type atpase
ANAE109_RS06250	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS06305	COG0297	glycogen (starch) synthase activity
ANAE109_RS06315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANAE109_RS06320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANAE109_RS06335	COG0367	asparagine synthase
ANAE109_RS06340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ANAE109_RS06345	COG0318	PFAM AMP-dependent synthetase and ligase
ANAE109_RS06350	COG1086	Polysaccharide biosynthesis protein
ANAE109_RS06360	COG1049	propionate catabolic process, 2-methylcitrate cycle
ANAE109_RS06390	COG0114	fumarate hydratase activity
ANAE109_RS06425	COG0693	protein deglycase activity
ANAE109_RS06430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANAE109_RS06435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ANAE109_RS06455	COG1355	regulation of microtubule-based process
ANAE109_RS06465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ANAE109_RS06475	COG0443	Heat shock 70 kDa protein
ANAE109_RS06480	COG0484	heat shock protein binding
ANAE109_RS06490	COG0010	Belongs to the arginase family
ANAE109_RS06495	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ANAE109_RS06500	COG1959	2 iron, 2 sulfur cluster binding
ANAE109_RS06505	COG0613	PHP domain protein
ANAE109_RS06510	COG1007	ATP synthesis coupled electron transport
ANAE109_RS06520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANAE109_RS06525	COG0713	ATP synthesis coupled electron transport
ANAE109_RS06535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS06540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ANAE109_RS06545	COG0649	NAD binding
ANAE109_RS06550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS06555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS06560	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS06565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS06570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS06575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS06580	COG0649	NAD binding
ANAE109_RS06585	COG1034	ATP synthesis coupled electron transport
ANAE109_RS06590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ANAE109_RS06595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS06610	COG2814	Major facilitator Superfamily
ANAE109_RS06635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ANAE109_RS06635	COG1796	DNA polymerase
ANAE109_RS06645	COG0521	Mo-molybdopterin cofactor biosynthetic process
ANAE109_RS06685	COG0011	TIGRFAM Protein of
ANAE109_RS06720	COG0586	Pfam SNARE associated Golgi protein
ANAE109_RS06725	COG2385	sporulation resulting in formation of a cellular spore
ANAE109_RS06730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ANAE109_RS06745	COG1862	Preprotein translocase
ANAE109_RS06750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANAE109_RS06755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ANAE109_RS06770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ANAE109_RS06770	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ANAE109_RS06805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ANAE109_RS06810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ANAE109_RS06825	COG1597	lipid kinase activity
ANAE109_RS06835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANAE109_RS06845	COG0612	Peptidase, M16
ANAE109_RS06860	COG2022	thiamine diphosphate biosynthetic process
ANAE109_RS06870	COG0352	thiamine-phosphate diphosphorylase activity
ANAE109_RS06910	COG1074	ATP-dependent DNA helicase activity
ANAE109_RS06955	COG0424	maF-like protein
ANAE109_RS06975	COG0768	penicillin binding
ANAE109_RS06980	COG0772	Belongs to the SEDS family
ANAE109_RS06985	COG3118	belongs to the thioredoxin family
ANAE109_RS06995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ANAE109_RS07000	COG0181	hydroxymethylbilane synthase activity
ANAE109_RS07015	COG0585	pseudouridine synthase activity
ANAE109_RS07020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANAE109_RS07055	COG2197	response regulator
ANAE109_RS07065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ANAE109_RS07070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ANAE109_RS07075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ANAE109_RS07075	COG0446	pyridine nucleotide-disulphide oxidoreductase
ANAE109_RS07120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANAE109_RS07125	COG0138	bifunctional purine biosynthesis protein purh
ANAE109_RS07170	COG1216	Glycosyl transferase, family 2
ANAE109_RS07175	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS07180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ANAE109_RS07190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANAE109_RS07195	COG0009	L-threonylcarbamoyladenylate synthase
ANAE109_RS07205	COG0113	porphobilinogen synthase activity
ANAE109_RS07220	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANAE109_RS07255	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS07260	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS07265	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS07280	COG1876	peptidase activity
ANAE109_RS07290	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANAE109_RS07295	COG2815	serine threonine protein kinase
ANAE109_RS07295	COG0515	serine threonine protein kinase
ANAE109_RS07310	COG1139	Iron-sulfur cluster binding protein
ANAE109_RS07315	COG0247	lactate metabolic process
ANAE109_RS07320	COG1620	l-lactate permease
ANAE109_RS07330	COG3279	Response regulator of the LytR AlgR family
ANAE109_RS07335	COG3275	phosphorelay sensor kinase activity
ANAE109_RS07345	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ANAE109_RS07355	COG0303	'Molybdopterin
ANAE109_RS07365	COG0557	exoribonuclease II activity
ANAE109_RS07375	COG0730	response to heat
ANAE109_RS07385	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ANAE109_RS07420	COG1193	negative regulation of DNA recombination
ANAE109_RS07440	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS07450	COG3876	Protein conserved in bacteria
ANAE109_RS07470	COG0542	response to heat
ANAE109_RS07475	COG1752	Esterase of the alpha-beta hydrolase superfamily
ANAE109_RS07500	COG0459	protein refolding
ANAE109_RS07510	COG3706	GGDEF domain
ANAE109_RS07525	COG0525	valine-tRNA ligase activity
ANAE109_RS07535	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ANAE109_RS07535	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ANAE109_RS07540	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ANAE109_RS07555	COG0728	peptidoglycan biosynthetic process
ANAE109_RS07585	COG1595	DNA-templated transcription, initiation
ANAE109_RS07595	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ANAE109_RS07600	COG2205	protein histidine kinase activity
ANAE109_RS07600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ANAE109_RS07615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ANAE109_RS07630	COG5002	protein histidine kinase activity
ANAE109_RS07640	COG1573	uracil-dna glycosylase
ANAE109_RS07650	COG0330	HflC and HflK could
ANAE109_RS07665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ANAE109_RS07685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ANAE109_RS07695	COG0501	Belongs to the peptidase M48B family
ANAE109_RS07725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANAE109_RS07735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ANAE109_RS07740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ANAE109_RS07745	COG0586	Pfam SNARE associated Golgi protein
ANAE109_RS07750	COG0443	Heat shock 70 kDa protein
ANAE109_RS07755	COG0517	IMP dehydrogenase activity
ANAE109_RS07755	COG0516	GMP reductase activity
ANAE109_RS07760	COG0519	Catalyzes the synthesis of GMP from XMP
ANAE109_RS07760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANAE109_RS07795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ANAE109_RS07805	COG3746	phosphate-selective porin O and P
ANAE109_RS07815	COG1121	(ABC) transporter
ANAE109_RS07855	COG3093	addiction module antidote protein HigA
ANAE109_RS07860	COG3012	SEC-C Motif Domain Protein
ANAE109_RS07865	COG2155	Conserved Protein
ANAE109_RS07925	COG3220	belongs to the UPF0276 family
ANAE109_RS07955	COG0667	Aldo Keto reductase
ANAE109_RS07975	COG0443	Heat shock 70 kDa protein
ANAE109_RS07985	COG3047	cAMP biosynthetic process
ANAE109_RS07985	COG2885	chlorophyll binding
ANAE109_RS07995	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ANAE109_RS08060	COG1793	dna ligase
ANAE109_RS08080	COG0039	L-malate dehydrogenase activity
ANAE109_RS08090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ANAE109_RS08115	COG1966	Carbon starvation protein
ANAE109_RS08120	COG2205	protein histidine kinase activity
ANAE109_RS08120	COG0784	Response regulator, receiver
ANAE109_RS08175	COG2264	protein methyltransferase activity
ANAE109_RS08195	COG0217	transcriptional regulatory protein
ANAE109_RS08205	COG4109	DRTGG domain
ANAE109_RS08210	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ANAE109_RS08220	COG1131	(ABC) transporter
ANAE109_RS08260	COG1252	NADH dehydrogenase
ANAE109_RS08290	COG0488	(ABC) transporter
ANAE109_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS08335	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ANAE109_RS08340	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ANAE109_RS08345	COG4208	sulfate ABC transporter
ANAE109_RS08355	COG0529	Catalyzes the synthesis of activated sulfate
ANAE109_RS08365	COG2895	sulfate adenylyltransferase (ATP) activity
ANAE109_RS08395	COG0318	PFAM AMP-dependent synthetase and ligase
ANAE109_RS08410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ANAE109_RS08425	COG1271	oxidase subunit
ANAE109_RS08430	COG1294	oxidase, subunit
ANAE109_RS08470	COG3842	ATPase activity
ANAE109_RS08480	COG0395	ABC-type sugar transport system, permease component
ANAE109_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
ANAE109_RS08490	COG0431	NADPH-dependent FMN reductase
ANAE109_RS08495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ANAE109_RS08520	COG2205	protein histidine kinase activity
ANAE109_RS08525	COG0671	phosphoesterase, PA-phosphatase related
ANAE109_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS08545	COG0559	Belongs to the binding-protein-dependent transport system permease family
ANAE109_RS08570	COG0667	Aldo Keto reductase
ANAE109_RS08585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ANAE109_RS08635	COG3842	ATPase activity
ANAE109_RS08650	COG1653	transport
ANAE109_RS08665	COG0259	pyridoxamine-phosphate oxidase activity
ANAE109_RS08675	COG2832	Protein of unknown function (DUF454)
ANAE109_RS08685	COG0408	coproporphyrinogen oxidase activity
ANAE109_RS08690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ANAE109_RS08705	COG1704	LemA family
ANAE109_RS08710	COG0501	Belongs to the peptidase M48B family
ANAE109_RS08720	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ANAE109_RS08735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ANAE109_RS08765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ANAE109_RS08770	COG2270	Major facilitator Superfamily
ANAE109_RS08780	COG2205	protein histidine kinase activity
ANAE109_RS08780	COG0784	Response regulator, receiver
ANAE109_RS08790	COG1201	RNA secondary structure unwinding
ANAE109_RS08795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ANAE109_RS08820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ANAE109_RS08870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ANAE109_RS08880	COG0328	RNA-DNA hybrid ribonuclease activity
ANAE109_RS08885	COG2195	Cleaves the N-terminal amino acid of tripeptides
ANAE109_RS08930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANAE109_RS08935	COG0473	3-isopropylmalate dehydrogenase activity
ANAE109_RS08940	COG4783	chaperone-mediated protein folding
ANAE109_RS08955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANAE109_RS08965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ANAE109_RS08970	COG3033	Beta-eliminating lyase
ANAE109_RS08995	COG0351	phosphomethylpyrimidine kinase
ANAE109_RS09005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANAE109_RS09035	COG1136	(ABC) transporter
ANAE109_RS09040	COG0577	efflux transmembrane transporter activity
ANAE109_RS09050	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ANAE109_RS09085	COG0569	domain protein
ANAE109_RS09125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ANAE109_RS09135	COG0583	DNA-binding transcription factor activity
ANAE109_RS09150	COG0788	formyltetrahydrofolate deformylase activity
ANAE109_RS09165	COG2204	response regulator
ANAE109_RS09175	COG3064	Membrane
ANAE109_RS09175	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS09180	COG5557	Pfam Polysulphide reductase, NrfD
ANAE109_RS09210	COG0501	Belongs to the peptidase M48B family
ANAE109_RS09225	COG2197	response regulator
ANAE109_RS09250	COG2226	methyltransferase
ANAE109_RS09280	COG1216	Glycosyl transferase, family 2
ANAE109_RS09285	COG1216	Glycosyl transferase, family 2
ANAE109_RS09300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ANAE109_RS09400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ANAE109_RS09405	COG4191	Histidine kinase
ANAE109_RS09410	COG2204	response regulator
ANAE109_RS09415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANAE109_RS09425	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS09430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ANAE109_RS09440	COG1217	gtp-binding protein TYPA
ANAE109_RS09445	COG5002	protein histidine kinase activity
ANAE109_RS09500	COG0598	Magnesium transport protein CorA
ANAE109_RS09510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANAE109_RS09555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANAE109_RS09560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ANAE109_RS09565	COG0066	3-isopropylmalate dehydratase activity
ANAE109_RS09585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ANAE109_RS09590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ANAE109_RS09595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ANAE109_RS09600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ANAE109_RS09605	COG0072	phenylalanine-tRNA ligase activity
ANAE109_RS09615	COG0776	regulation of translation
ANAE109_RS09625	COG0720	synthase
ANAE109_RS09630	COG0302	gtp cyclohydrolase
ANAE109_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS09640	COG0277	FAD linked oxidase domain protein
ANAE109_RS09645	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANAE109_RS09645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANAE109_RS09650	COG1013	pyruvate-flavodoxin oxidoreductase activity
ANAE109_RS09660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANAE109_RS09660	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANAE109_RS09665	COG1013	pyruvate-flavodoxin oxidoreductase activity
ANAE109_RS09705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ANAE109_RS09725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ANAE109_RS09730	COG0049	tRNA binding
ANAE109_RS09735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANAE109_RS09740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANAE109_RS09745	COG0051	transcription antitermination factor activity, RNA binding
ANAE109_RS09750	COG0088	Forms part of the polypeptide exit tunnel
ANAE109_RS09755	COG0089	rRNA binding
ANAE109_RS09760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ANAE109_RS09765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ANAE109_RS09770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ANAE109_RS09775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ANAE109_RS09780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ANAE109_RS09785	COG0255	Belongs to the universal ribosomal protein uL29 family
ANAE109_RS09790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ANAE109_RS09795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ANAE109_RS09800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ANAE109_RS09805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ANAE109_RS09810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ANAE109_RS09815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ANAE109_RS09820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ANAE109_RS09825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ANAE109_RS09830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ANAE109_RS09835	COG1841	ribosomal large subunit assembly
ANAE109_RS09840	COG0200	Binds to the 23S rRNA
ANAE109_RS09845	COG0201	protein transport
ANAE109_RS09850	COG0563	adenylate kinase activity
ANAE109_RS09860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ANAE109_RS09865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ANAE109_RS09870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ANAE109_RS09875	COG0202	RNA polymerase activity
ANAE109_RS09880	COG0203	ribosomal protein L17
ANAE109_RS09890	COG0228	four-way junction DNA binding
ANAE109_RS09895	COG1837	Belongs to the UPF0109 family
ANAE109_RS09900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ANAE109_RS09905	COG0336	Belongs to the RNA methyltransferase TrmD family
ANAE109_RS09910	COG0335	large ribosomal subunit rRNA binding
ANAE109_RS09920	COG0792	nuclease activity
ANAE109_RS09925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ANAE109_RS09945	COG3852	Histidine kinase
ANAE109_RS09975	COG0564	pseudouridine synthase activity
ANAE109_RS10005	COG1166	arginine decarboxylase activity
ANAE109_RS10015	COG3360	Dodecin
ANAE109_RS10020	COG2226	methyltransferase
ANAE109_RS10065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ANAE109_RS10090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANAE109_RS10095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ANAE109_RS10125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS10125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS10130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS10130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS10145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ANAE109_RS10155	COG0022	dehydrogenase e1 component
ANAE109_RS10170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ANAE109_RS10190	COG0527	aspartate kinase activity
ANAE109_RS10215	COG2205	protein histidine kinase activity
ANAE109_RS10215	COG0784	Response regulator, receiver
ANAE109_RS10220	COG0436	Aminotransferase
ANAE109_RS10225	COG3383	formate dehydrogenase (NAD+) activity
ANAE109_RS10225	COG0243	molybdopterin cofactor binding
ANAE109_RS10230	COG0243	molybdopterin cofactor binding
ANAE109_RS10230	COG3383	formate dehydrogenase (NAD+) activity
ANAE109_RS10235	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS10240	COG2864	formate dehydrogenase
ANAE109_RS10245	COG3058	Necessary for formate dehydrogenase activity
ANAE109_RS10300	COG0443	Heat shock 70 kDa protein
ANAE109_RS10330	COG0698	ribose 5-phosphate isomerase
ANAE109_RS10345	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS10350	COG5002	protein histidine kinase activity
ANAE109_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS10390	COG0546	phosphoglycolate phosphatase activity
ANAE109_RS10395	COG1970	mechanosensitive ion channel activity
ANAE109_RS10405	COG0646	methionine synthase
ANAE109_RS10405	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ANAE109_RS10410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ANAE109_RS10430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ANAE109_RS10435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ANAE109_RS10465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ANAE109_RS10470	COG0560	Phosphoserine phosphatase
ANAE109_RS10515	COG2267	carboxylic ester hydrolase activity
ANAE109_RS10530	COG0742	ribosomal rna small subunit methyltransferase
ANAE109_RS10535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ANAE109_RS10570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ANAE109_RS10580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ANAE109_RS10585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ANAE109_RS10595	COG0436	Aminotransferase
ANAE109_RS10610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ANAE109_RS10615	COG1058	Belongs to the CinA family
ANAE109_RS10615	COG1546	Belongs to the CinA family
ANAE109_RS10640	COG0166	Belongs to the GPI family
ANAE109_RS10650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ANAE109_RS10665	COG2204	response regulator
ANAE109_RS10675	COG2815	serine threonine protein kinase
ANAE109_RS10675	COG0515	serine threonine protein kinase
ANAE109_RS10685	COG0667	Aldo Keto reductase
ANAE109_RS10695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANAE109_RS10730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ANAE109_RS10745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ANAE109_RS10760	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ANAE109_RS10765	COG0860	N-Acetylmuramoyl-L-alanine amidase
ANAE109_RS10770	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ANAE109_RS10775	COG0189	ligase activity
ANAE109_RS10790	COG0009	L-threonylcarbamoyladenylate synthase
ANAE109_RS10795	COG4974	Belongs to the 'phage' integrase family
ANAE109_RS10800	COG1994	Peptidase M50
ANAE109_RS10805	COG0180	Tryptophanyl-tRNA synthetase
ANAE109_RS10810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ANAE109_RS10815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ANAE109_RS10845	COG0430	RNA-3'-phosphate cyclase activity
ANAE109_RS10850	COG0598	Magnesium transport protein CorA
ANAE109_RS10860	COG0489	protein tyrosine kinase activity
ANAE109_RS10880	COG1250	3-hydroxyacyl-CoA dehydrogenase
ANAE109_RS10885	COG1024	Enoyl-CoA hydratase
ANAE109_RS10890	COG1960	acyl-CoA dehydrogenase activity
ANAE109_RS10895	COG1960	acyl-CoA dehydrogenase activity
ANAE109_RS10900	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ANAE109_RS10905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANAE109_RS10920	COG5002	protein histidine kinase activity
ANAE109_RS10935	COG0420	3'-5' exonuclease activity
ANAE109_RS10945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ANAE109_RS10950	COG0450	alkyl hydroperoxide reductase
ANAE109_RS10985	COG1160	GTP binding
ANAE109_RS10990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ANAE109_RS11005	COG0571	ribonuclease III activity
ANAE109_RS11020	COG0110	maltose O-acetyltransferase activity
ANAE109_RS11025	COG1960	acyl-CoA dehydrogenase activity
ANAE109_RS11030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ANAE109_RS11035	COG1024	Enoyl-CoA hydratase
ANAE109_RS11040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANAE109_RS11045	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ANAE109_RS11050	COG0148	phosphopyruvate hydratase activity
ANAE109_RS11065	COG1494	fructose-1,6-bisphosphatase
ANAE109_RS11110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ANAE109_RS11115	COG1253	flavin adenine dinucleotide binding
ANAE109_RS11120	COG0105	UTP biosynthetic process
ANAE109_RS11125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ANAE109_RS11135	COG0039	L-malate dehydrogenase activity
ANAE109_RS11140	COG0538	isocitrate dehydrogenase activity
ANAE109_RS11145	COG3394	polysaccharide catabolic process
ANAE109_RS11150	COG4191	Histidine kinase
ANAE109_RS11165	COG0505	Belongs to the CarA family
ANAE109_RS11175	COG0540	Belongs to the ATCase OTCase family
ANAE109_RS11180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ANAE109_RS11190	COG0681	Belongs to the peptidase S26 family
ANAE109_RS11195	COG0481	GTPase activity
ANAE109_RS11200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ANAE109_RS11230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANAE109_RS11235	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ANAE109_RS11240	COG5002	protein histidine kinase activity
ANAE109_RS11260	COG0741	lytic transglycosylase activity
ANAE109_RS11265	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ANAE109_RS11285	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS11300	COG1317	bacterial-type flagellum organization
ANAE109_RS11305	COG0864	Transcriptional regulator
ANAE109_RS11315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ANAE109_RS11320	COG0085	RNA polymerase activity
ANAE109_RS11325	COG0222	ribosome binding
ANAE109_RS11330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ANAE109_RS11335	COG0081	regulation of translation
ANAE109_RS11340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ANAE109_RS11360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ANAE109_RS11365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ANAE109_RS11390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANAE109_RS11400	COG0189	ligase activity
ANAE109_RS11405	COG0443	Heat shock 70 kDa protein
ANAE109_RS11415	COG5002	protein histidine kinase activity
ANAE109_RS11415	COG0784	Response regulator, receiver
ANAE109_RS11415	COG2205	protein histidine kinase activity
ANAE109_RS11430	COG2921	Belongs to the UPF0250 family
ANAE109_RS11435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ANAE109_RS11480	COG1730	sister chromatid segregation
ANAE109_RS11540	COG2204	response regulator
ANAE109_RS11545	COG4191	Histidine kinase
ANAE109_RS11570	COG0443	Heat shock 70 kDa protein
ANAE109_RS11580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ANAE109_RS11595	COG0101	tRNA pseudouridine synthase activity
ANAE109_RS11605	COG1606	tRNA processing
ANAE109_RS11610	COG2046	Belongs to the sulfate adenylyltransferase family
ANAE109_RS11610	COG0529	Catalyzes the synthesis of activated sulfate
ANAE109_RS11615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ANAE109_RS11625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ANAE109_RS11655	COG0149	triose-phosphate isomerase activity
ANAE109_RS11660	COG0126	phosphoglycerate kinase activity
ANAE109_RS11665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ANAE109_RS11675	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ANAE109_RS11695	COG0018	arginyl-trna synthetase
ANAE109_RS11710	COG0616	signal peptide processing
ANAE109_RS11715	COG3273	potassium ion transport
ANAE109_RS11715	COG0471	metal ion transport
ANAE109_RS11720	COG0835	chemotaxis
ANAE109_RS11745	COG2201	protein-glutamate methylesterase activity
ANAE109_RS11760	COG0539	negative regulation of cytoplasmic translation
ANAE109_RS11765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ANAE109_RS11770	COG1122	ATPase activity
ANAE109_RS11780	COG0310	cobalt ion transport
ANAE109_RS11800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ANAE109_RS11805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ANAE109_RS11810	COG0825	malonyl-CoA metabolic process
ANAE109_RS11815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ANAE109_RS11830	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ANAE109_RS11870	COG3209	COG3209 Rhs family protein
ANAE109_RS11880	COG3209	COG3209 Rhs family protein
ANAE109_RS11890	COG3209	COG3209 Rhs family protein
ANAE109_RS11895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANAE109_RS11910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANAE109_RS11915	COG0802	atpase or kinase
ANAE109_RS11920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ANAE109_RS11920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ANAE109_RS11925	COG0736	holo-[acyl-carrier-protein] synthase activity
ANAE109_RS11930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ANAE109_RS11935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ANAE109_RS11945	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ANAE109_RS11950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ANAE109_RS11955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANAE109_RS11960	COG0037	tRNA processing
ANAE109_RS11990	COG3246	L-lysine catabolic process to acetate
ANAE109_RS11995	COG1607	acyl-coa hydrolase
ANAE109_RS12000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS12010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ANAE109_RS12015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANAE109_RS12020	COG0482	sulfurtransferase activity
ANAE109_RS12025	COG2205	protein histidine kinase activity
ANAE109_RS12030	COG0617	tRNA 3'-terminal CCA addition
ANAE109_RS12060	COG2226	methyltransferase
ANAE109_RS12075	COG3118	belongs to the thioredoxin family
ANAE109_RS12110	COG2201	protein-glutamate methylesterase activity
ANAE109_RS12130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ANAE109_RS12145	COG3387	PFAM Glycoside hydrolase 15-related
ANAE109_RS12175	COG2205	protein histidine kinase activity
ANAE109_RS12180	COG2204	response regulator
ANAE109_RS12220	COG5002	protein histidine kinase activity
ANAE109_RS12235	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ANAE109_RS12240	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS12250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ANAE109_RS12290	COG3148	PFAM DTW domain containing protein
ANAE109_RS12300	COG0429	hydrolase of the alpha beta-hydrolase fold
ANAE109_RS12320	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS12330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANAE109_RS12360	COG0038	chloride channel
ANAE109_RS12380	COG0308	aminopeptidase N
ANAE109_RS12405	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ANAE109_RS12410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ANAE109_RS12415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ANAE109_RS12440	COG3604	Transcriptional regulator
ANAE109_RS12445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ANAE109_RS12455	COG1763	Mo-molybdopterin cofactor biosynthetic process
ANAE109_RS12460	COG0303	'Molybdopterin
ANAE109_RS12470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ANAE109_RS12480	COG0517	IMP dehydrogenase activity
ANAE109_RS12485	COG2205	protein histidine kinase activity
ANAE109_RS12490	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS12490	COG4566	intracellular signal transduction
ANAE109_RS12495	COG3852	Histidine kinase
ANAE109_RS12510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ANAE109_RS12520	COG1335	isochorismatase
ANAE109_RS12535	COG0084	hydrolase, TatD family'
ANAE109_RS12540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANAE109_RS12540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANAE109_RS12555	COG0784	Response regulator, receiver
ANAE109_RS12555	COG2198	Histidine kinase
ANAE109_RS12555	COG5002	protein histidine kinase activity
ANAE109_RS12565	COG0288	reversible hydration of carbon dioxide
ANAE109_RS12595	COG0752	glycyl-tRNA synthetase alpha subunit
ANAE109_RS12605	COG1381	Involved in DNA repair and RecF pathway recombination
ANAE109_RS12630	COG0602	queuosine metabolic process
ANAE109_RS12635	COG0741	lytic transglycosylase activity
ANAE109_RS12650	COG0167	dihydroorotate dehydrogenase activity
ANAE109_RS12675	COG2937	Belongs to the GPAT DAPAT family
ANAE109_RS12685	COG0483	inositol monophosphate 1-phosphatase activity
ANAE109_RS12695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANAE109_RS12700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ANAE109_RS12725	COG1045	serine acetyltransferase
ANAE109_RS12735	COG0322	excinuclease ABC activity
ANAE109_RS12760	COG0556	nucleotide-excision repair
ANAE109_RS12765	COG1278	Cold shock
ANAE109_RS12775	COG0215	cysteine-tRNA ligase activity
ANAE109_RS12780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ANAE109_RS12780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ANAE109_RS12785	COG1329	Transcriptional regulator
ANAE109_RS12815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ANAE109_RS12820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ANAE109_RS12825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANAE109_RS12830	COG1309	transcriptional regulator
ANAE109_RS12835	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ANAE109_RS12850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ANAE109_RS12855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ANAE109_RS12860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ANAE109_RS12870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ANAE109_RS12895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ANAE109_RS12905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ANAE109_RS12915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANAE109_RS12920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ANAE109_RS12940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ANAE109_RS12950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ANAE109_RS12955	COG1278	Cold shock
ANAE109_RS12970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ANAE109_RS12975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ANAE109_RS12980	COG2766	serine protein kinase
ANAE109_RS12985	COG2718	Belongs to the UPF0229 family
ANAE109_RS12990	COG2719	SpoVR family
ANAE109_RS12995	COG1196	nuclear chromosome segregation
ANAE109_RS12995	COG0741	lytic transglycosylase activity
ANAE109_RS12995	COG0739	heme binding
ANAE109_RS13035	COG1047	Peptidyl-prolyl cis-trans
ANAE109_RS13055	COG3411	Ferredoxin
ANAE109_RS13060	COG2912	Transglutaminase-like superfamily
ANAE109_RS13075	COG2207	Transcriptional regulator
ANAE109_RS13080	COG3848	Pyruvate phosphate dikinase
ANAE109_RS13080	COG0574	Belongs to the PEP-utilizing enzyme family
ANAE109_RS13085	COG1741	Belongs to the pirin family
ANAE109_RS13090	COG5002	protein histidine kinase activity
ANAE109_RS13090	COG5001	Diguanylate cyclase
ANAE109_RS13090	COG3447	MASE1 domain protein
ANAE109_RS13100	COG1394	ATPase activity, coupled to movement of substances
ANAE109_RS13105	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
ANAE109_RS13110	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
ANAE109_RS13135	COG1269	ATP hydrolysis coupled proton transport
ANAE109_RS13185	COG0194	GDP metabolic process
ANAE109_RS13190	COG1561	YicC-like family, N-terminal region
ANAE109_RS13195	COG2835	tetraacyldisaccharide 4'-kinase activity
ANAE109_RS13205	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ANAE109_RS13205	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ANAE109_RS13210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ANAE109_RS13210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ANAE109_RS13220	COG1663	tetraacyldisaccharide 4'-kinase activity
ANAE109_RS13225	COG0859	PFAM glycosyl transferase family 9
ANAE109_RS13230	COG1519	Transferase
ANAE109_RS13240	COG1132	(ABC) transporter
ANAE109_RS13245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANAE109_RS13250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANAE109_RS13255	COG2095	MarC family integral membrane protein
ANAE109_RS13260	COG0463	Glycosyl transferase, family 2
ANAE109_RS13265	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ANAE109_RS13335	COG1053	succinate dehydrogenase
ANAE109_RS13355	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS13385	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ANAE109_RS13390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANAE109_RS13395	COG0489	protein tyrosine kinase activity
ANAE109_RS13420	COG2204	response regulator
ANAE109_RS13435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ANAE109_RS13485	COG0489	protein tyrosine kinase activity
ANAE109_RS13485	COG3206	protein involved in exopolysaccharide biosynthesis
ANAE109_RS13490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ANAE109_RS13500	COG1086	Polysaccharide biosynthesis protein
ANAE109_RS13505	COG2385	sporulation resulting in formation of a cellular spore
ANAE109_RS13520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ANAE109_RS13570	COG0492	ferredoxin-NADP+ reductase activity
ANAE109_RS13590	COG0582	viral genome integration into host DNA
ANAE109_RS13650	COG4269	membrane
ANAE109_RS13680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ANAE109_RS13685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ANAE109_RS13705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ANAE109_RS13720	COG0237	dephospho-CoA kinase activity
ANAE109_RS13745	COG0137	argininosuccinate synthase activity
ANAE109_RS13760	COG0443	Heat shock 70 kDa protein
ANAE109_RS13765	COG0484	heat shock protein binding
ANAE109_RS13775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ANAE109_RS13780	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ANAE109_RS13785	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ANAE109_RS13800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ANAE109_RS13810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ANAE109_RS13815	COG0758	DNA mediated transformation
ANAE109_RS13820	COG1652	LysM domain
ANAE109_RS13830	COG1496	oxidoreductase activity
ANAE109_RS13835	COG5001	Diguanylate cyclase
ANAE109_RS13835	COG4251	negative regulation of phosphorylation
ANAE109_RS13835	COG3706	GGDEF domain
ANAE109_RS13835	COG2203	Gaf domain
ANAE109_RS13840	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS13840	COG1196	nuclear chromosome segregation
ANAE109_RS13850	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ANAE109_RS13855	COG0542	response to heat
ANAE109_RS13885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ANAE109_RS13890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ANAE109_RS13900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ANAE109_RS13905	COG1480	7TM receptor with intracellular HD hydrolase
ANAE109_RS13915	COG0457	Tetratricopeptide repeat
ANAE109_RS13925	COG3956	TIGRFAM MazG family protein
ANAE109_RS13930	COG0268	Binds directly to 16S ribosomal RNA
ANAE109_RS13940	COG0495	leucyl-tRNA aminoacylation
ANAE109_RS13945	COG0017	Asparaginyl-tRNA synthetase
ANAE109_RS13970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ANAE109_RS13970	COG0392	lysyltransferase activity
ANAE109_RS13980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ANAE109_RS13985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ANAE109_RS13990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ANAE109_RS13990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ANAE109_RS14000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANAE109_RS14000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ANAE109_RS14005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ANAE109_RS14010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ANAE109_RS14015	COG0698	ribose 5-phosphate isomerase
ANAE109_RS14020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ANAE109_RS14025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANAE109_RS14030	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS14035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ANAE109_RS14040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ANAE109_RS14045	COG0416	fatty acid biosynthetic process
ANAE109_RS14050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ANAE109_RS14085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ANAE109_RS14100	COG0457	Tetratricopeptide repeat
ANAE109_RS14100	COG0705	Rhomboid family
ANAE109_RS14115	COG3186	Phenylalanine-4-hydroxylase
ANAE109_RS14125	COG0488	(ABC) transporter
ANAE109_RS14140	COG3256	nitric oxide reductase
ANAE109_RS14150	COG1858	cytochrome C peroxidase
ANAE109_RS14175	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS14190	COG1858	cytochrome C peroxidase
ANAE109_RS14225	COG0604	alcohol dehydrogenase
ANAE109_RS14245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ANAE109_RS14250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ANAE109_RS14260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ANAE109_RS14275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ANAE109_RS14310	COG1301	dicarboxylic acid transport
ANAE109_RS14325	COG1067	ATP-dependent peptidase activity
ANAE109_RS14345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ANAE109_RS14400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ANAE109_RS14415	COG0406	alpha-ribazole phosphatase activity
ANAE109_RS14420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ANAE109_RS14430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANAE109_RS14430	COG1017	nitric oxide dioxygenase activity
ANAE109_RS14450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANAE109_RS14450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ANAE109_RS14455	COG0604	alcohol dehydrogenase
ANAE109_RS14475	COG2205	protein histidine kinase activity
ANAE109_RS14490	COG2323	membrane
ANAE109_RS14510	COG3795	YCII-related domain
ANAE109_RS14515	COG4941	Belongs to the sigma-70 factor family
ANAE109_RS14550	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ANAE109_RS14560	COG0288	reversible hydration of carbon dioxide
ANAE109_RS14565	COG1360	Flagellar Motor Protein
ANAE109_RS14585	COG2234	aminopeptidase activity
ANAE109_RS14590	COG0823	Involved in the tonB-independent uptake of proteins
ANAE109_RS14595	COG0583	DNA-binding transcription factor activity
ANAE109_RS14660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ANAE109_RS14680	COG1845	cytochrome c oxidase, subunit III
ANAE109_RS14690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ANAE109_RS14740	COG1960	acyl-CoA dehydrogenase activity
ANAE109_RS14745	COG0183	Belongs to the thiolase family
ANAE109_RS14750	COG1250	3-hydroxyacyl-CoA dehydrogenase
ANAE109_RS14750	COG1024	Enoyl-CoA hydratase
ANAE109_RS14800	COG1881	PFAM PEBP family protein
ANAE109_RS14805	COG0667	Aldo Keto reductase
ANAE109_RS14825	COG2827	Endonuclease containing a URI domain
ANAE109_RS14830	COG1752	Esterase of the alpha-beta hydrolase superfamily
ANAE109_RS14900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ANAE109_RS14910	COG0531	amino acid
ANAE109_RS14940	COG2010	Cytochrome c
ANAE109_RS14940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ANAE109_RS14960	COG0247	lactate metabolic process
ANAE109_RS14965	COG0277	FAD linked oxidase domain protein
ANAE109_RS14970	COG0277	FAD linked oxidase domain protein
ANAE109_RS14985	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ANAE109_RS15005	COG2388	GCN5-related N-acetyl-transferase
ANAE109_RS15020	COG1063	alcohol dehydrogenase
ANAE109_RS15060	COG1032	radical SAM domain protein
ANAE109_RS15070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ANAE109_RS15105	COG2264	protein methyltransferase activity
ANAE109_RS15110	COG1297	OPT oligopeptide transporter protein
ANAE109_RS15125	COG0517	IMP dehydrogenase activity
ANAE109_RS15130	COG2860	membrane
ANAE109_RS15160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ANAE109_RS15185	COG1136	(ABC) transporter
ANAE109_RS15185	COG0577	efflux transmembrane transporter activity
ANAE109_RS15195	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ANAE109_RS15220	COG0366	Alpha amylase catalytic
ANAE109_RS15250	COG1064	alcohol dehydrogenase
ANAE109_RS15260	COG4191	Histidine kinase
ANAE109_RS15285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ANAE109_RS15300	COG0318	PFAM AMP-dependent synthetase and ligase
ANAE109_RS15340	COG1013	pyruvate-flavodoxin oxidoreductase activity
ANAE109_RS15345	COG0674	pyruvate-flavodoxin oxidoreductase activity
ANAE109_RS15345	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ANAE109_RS15350	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ANAE109_RS15365	COG0277	FAD linked oxidase domain protein
ANAE109_RS15370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ANAE109_RS15380	COG1960	acyl-CoA dehydrogenase activity
ANAE109_RS15395	COG2205	protein histidine kinase activity
ANAE109_RS15400	COG0702	epimerase
ANAE109_RS15415	COG1295	ribonuclease BN
ANAE109_RS15425	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ANAE109_RS15435	COG0443	Heat shock 70 kDa protein
ANAE109_RS15460	COG0656	L-ascorbic acid biosynthetic process
ANAE109_RS15465	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ANAE109_RS15465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ANAE109_RS15470	COG3639	organic phosphonate transmembrane transporter activity
ANAE109_RS15475	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ANAE109_RS15505	COG0535	radical SAM domain protein
ANAE109_RS15520	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANAE109_RS15525	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANAE109_RS15530	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ANAE109_RS15575	COG0733	neurotransmitter:sodium symporter activity
ANAE109_RS15580	COG1115	amino acid carrier protein
ANAE109_RS15600	COG3064	Membrane
ANAE109_RS15600	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS15605	COG3383	formate dehydrogenase (NAD+) activity
ANAE109_RS15605	COG0243	molybdopterin cofactor binding
ANAE109_RS15615	COG3284	Transcriptional regulator
ANAE109_RS15625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ANAE109_RS15640	COG0667	Aldo Keto reductase
ANAE109_RS15645	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ANAE109_RS15645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ANAE109_RS15670	COG1174	glycine betaine transport
ANAE109_RS15675	COG0517	IMP dehydrogenase activity
ANAE109_RS15675	COG1125	glycine betaine transport
ANAE109_RS15695	COG5522	Integral membrane protein (intg_mem_TP0381)
ANAE109_RS15700	COG1272	protein, Hemolysin III
ANAE109_RS15745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ANAE109_RS15750	COG0366	Alpha amylase catalytic
ANAE109_RS15805	COG0071	Belongs to the small heat shock protein (HSP20) family
ANAE109_RS15885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ANAE109_RS15890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ANAE109_RS15905	COG1942	4-Oxalocrotonate Tautomerase
ANAE109_RS15910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ANAE109_RS15920	COG0531	amino acid
ANAE109_RS15930	COG2205	protein histidine kinase activity
ANAE109_RS15935	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS15950	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS15960	COG2132	Multicopper oxidase
ANAE109_RS15960	COG2132	Multicopper oxidase
ANAE109_RS15960	COG2132	Multicopper oxidase
ANAE109_RS15990	COG1942	4-Oxalocrotonate Tautomerase
ANAE109_RS16055	COG0515	serine threonine protein kinase
ANAE109_RS16055	COG2815	serine threonine protein kinase
ANAE109_RS16070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ANAE109_RS16070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANAE109_RS16135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ANAE109_RS16170	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ANAE109_RS16195	COG2264	protein methyltransferase activity
ANAE109_RS16210	COG1773	rubredoxin
ANAE109_RS16210	COG1592	Rubrerythrin
ANAE109_RS16215	COG3590	peptidase
ANAE109_RS16230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ANAE109_RS16260	COG0045	succinate-CoA ligase (ADP-forming) activity
ANAE109_RS16260	COG1042	CoA-binding domain protein
ANAE109_RS16260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ANAE109_RS16270	COG2086	electron transfer activity
ANAE109_RS16280	COG1960	acyl-CoA dehydrogenase activity
ANAE109_RS16285	COG1703	isobutyryl-CoA mutase activity
ANAE109_RS16285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS16285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ANAE109_RS16290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANAE109_RS16295	COG2226	methyltransferase
ANAE109_RS16300	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ANAE109_RS16305	COG3845	ABC transporter
ANAE109_RS16310	COG4603	Belongs to the binding-protein-dependent transport system permease family
ANAE109_RS16345	COG0628	permease
ANAE109_RS16350	COG1032	radical SAM domain protein
ANAE109_RS16375	COG3040	lipid binding
ANAE109_RS16380	COG3239	Fatty acid desaturase
ANAE109_RS16385	COG2205	protein histidine kinase activity
ANAE109_RS16400	COG2353	YceI-like domain
ANAE109_RS16410	COG3384	dioxygenase
ANAE109_RS16425	COG2855	membrane
ANAE109_RS16435	COG0025	NhaP-type Na H and K H
ANAE109_RS16470	COG0667	Aldo Keto reductase
ANAE109_RS16475	COG1064	alcohol dehydrogenase
ANAE109_RS16480	COG1064	alcohol dehydrogenase
ANAE109_RS16515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANAE109_RS16520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANAE109_RS16530	COG0673	inositol 2-dehydrogenase activity
ANAE109_RS16545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ANAE109_RS16565	COG1132	(ABC) transporter
ANAE109_RS16580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ANAE109_RS16590	COG0583	DNA-binding transcription factor activity
ANAE109_RS16600	COG0641	radical SAM
ANAE109_RS16610	COG0659	secondary active sulfate transmembrane transporter activity
ANAE109_RS16640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ANAE109_RS16650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ANAE109_RS16655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ANAE109_RS16680	COG1764	response to oxidative stress
ANAE109_RS16690	COG1309	transcriptional regulator
ANAE109_RS16695	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS16710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ANAE109_RS16715	COG2226	methyltransferase
ANAE109_RS16755	COG1472	Belongs to the glycosyl hydrolase 3 family
ANAE109_RS16785	COG0653	protein targeting
ANAE109_RS16795	COG2249	NAD(P)H dehydrogenase (quinone) activity
ANAE109_RS16805	COG2201	protein-glutamate methylesterase activity
ANAE109_RS16840	COG2207	Transcriptional regulator
ANAE109_RS16840	COG1917	Cupin 2, conserved barrel domain protein
ANAE109_RS16860	COG1484	DNA-dependent DNA replication
ANAE109_RS16930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANAE109_RS16965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ANAE109_RS16985	COG0656	L-ascorbic acid biosynthetic process
ANAE109_RS16995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANAE109_RS17005	COG3959	Transketolase, thiamine diphosphate binding domain
ANAE109_RS17025	COG0542	response to heat
ANAE109_RS17035	COG0071	Belongs to the small heat shock protein (HSP20) family
ANAE109_RS17045	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ANAE109_RS17050	COG0589	response to stress
ANAE109_RS17090	COG0693	protein deglycase activity
ANAE109_RS17095	COG0071	Belongs to the small heat shock protein (HSP20) family
ANAE109_RS17130	COG0006	proline dipeptidase activity
ANAE109_RS17155	COG0604	alcohol dehydrogenase
ANAE109_RS17165	COG2815	serine threonine protein kinase
ANAE109_RS17165	COG0515	serine threonine protein kinase
ANAE109_RS17175	COG0477	Major facilitator Superfamily
ANAE109_RS17190	COG2197	response regulator
ANAE109_RS17245	COG2204	response regulator
ANAE109_RS17260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ANAE109_RS17295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ANAE109_RS17320	COG0488	(ABC) transporter
ANAE109_RS17325	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ANAE109_RS17425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ANAE109_RS17465	COG2204	response regulator
ANAE109_RS17485	COG5000	phosphorelay sensor kinase activity
ANAE109_RS17505	COG2252	PERMEase
ANAE109_RS17510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ANAE109_RS17520	COG2521	methyltransferase
ANAE109_RS17520	COG2136	Putative SAM-dependent methyltransferase
ANAE109_RS17525	COG3279	Response regulator of the LytR AlgR family
ANAE109_RS17530	COG3275	phosphorelay sensor kinase activity
ANAE109_RS17550	COG0740	serine-type endopeptidase activity
ANAE109_RS17555	COG0544	peptidyl-prolyl cis-trans isomerase activity
ANAE109_RS17595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ANAE109_RS17600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ANAE109_RS17610	COG0709	Synthesizes selenophosphate from selenide and ATP
ANAE109_RS17650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANAE109_RS17660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ANAE109_RS17665	COG2234	aminopeptidase activity
ANAE109_RS17685	COG0564	pseudouridine synthase activity
ANAE109_RS17705	COG1121	(ABC) transporter
ANAE109_RS17715	COG1196	nuclear chromosome segregation
ANAE109_RS17715	COG0739	heme binding
ANAE109_RS17715	COG0741	lytic transglycosylase activity
ANAE109_RS17750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ANAE109_RS17765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANAE109_RS17775	COG1619	proteins homologs of microcin C7 resistance protein MccF
ANAE109_RS17780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ANAE109_RS17785	COG0628	permease
ANAE109_RS17790	COG0545	Peptidyl-prolyl cis-trans isomerase
ANAE109_RS17795	COG0625	glutathione transferase activity
ANAE109_RS17840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ANAE109_RS17870	COG2226	methyltransferase
ANAE109_RS17905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ANAE109_RS17910	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ANAE109_RS17950	COG0513	Belongs to the DEAD box helicase family
ANAE109_RS17955	COG3123	guanosine phosphorylase activity
ANAE109_RS18040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ANAE109_RS18060	COG2226	methyltransferase
ANAE109_RS18060	COG0596	Alpha beta hydrolase
ANAE109_RS18060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ANAE109_RS18070	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ANAE109_RS18075	COG5557	Pfam Polysulphide reductase, NrfD
ANAE109_RS18080	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS18085	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ANAE109_RS18090	COG5557	Pfam Polysulphide reductase, NrfD
ANAE109_RS18105	COG1360	Flagellar Motor Protein
ANAE109_RS18130	COG2201	protein-glutamate methylesterase activity
ANAE109_RS18195	COG2321	neutral zinc metallopeptidase
ANAE109_RS18200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ANAE109_RS18215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ANAE109_RS18235	COG0587	DNA-directed DNA polymerase activity
ANAE109_RS18250	COG2197	response regulator
ANAE109_RS18255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ANAE109_RS18270	COG2815	serine threonine protein kinase
ANAE109_RS18270	COG0515	serine threonine protein kinase
ANAE109_RS18290	COG0156	8-amino-7-oxononanoate synthase activity
ANAE109_RS18295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ANAE109_RS18305	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ANAE109_RS18310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ANAE109_RS18315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ANAE109_RS18355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ANAE109_RS18360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ANAE109_RS18370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ANAE109_RS18375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ANAE109_RS18415	COG2096	Adenosyltransferase
ANAE109_RS18425	COG0316	Belongs to the HesB IscA family
ANAE109_RS18430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANAE109_RS18435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ANAE109_RS18445	COG0746	molybdenum cofactor guanylyltransferase activity
ANAE109_RS18455	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ANAE109_RS18460	COG1140	nitrate reductase beta subunit
ANAE109_RS18475	COG2223	nitrite transmembrane transporter activity
ANAE109_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS18500	COG1648	precorrin-2 dehydrogenase activity
ANAE109_RS18500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ANAE109_RS18505	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ANAE109_RS18510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ANAE109_RS18530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ANAE109_RS18555	COG1741	Belongs to the pirin family
ANAE109_RS18570	COG0006	proline dipeptidase activity
ANAE109_RS18575	COG3875	lactate racemase activity
ANAE109_RS18605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANAE109_RS18625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ANAE109_RS18630	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ANAE109_RS18635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ANAE109_RS18655	COG2202	Pas domain
ANAE109_RS18655	COG2205	protein histidine kinase activity
ANAE109_RS18665	COG0347	Belongs to the P(II) protein family
ANAE109_RS18670	COG0004	ammonium transporteR
ANAE109_RS18675	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS18685	COG2353	YceI-like domain
ANAE109_RS18690	COG0583	DNA-binding transcription factor activity
ANAE109_RS18700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ANAE109_RS18705	COG0798	PFAM Bile acid sodium symporter
ANAE109_RS18760	COG0622	Phosphoesterase
ANAE109_RS18840	COG2197	response regulator
ANAE109_RS18845	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANAE109_RS18845	COG0596	Alpha beta hydrolase
ANAE109_RS18855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ANAE109_RS18855	COG0519	Catalyzes the synthesis of GMP from XMP
ANAE109_RS18865	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ANAE109_RS18920	COG1196	nuclear chromosome segregation
ANAE109_RS18920	COG0741	lytic transglycosylase activity
ANAE109_RS18920	COG0739	heme binding
ANAE109_RS18935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ANAE109_RS18985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ANAE109_RS18990	COG1090	epimerase
ANAE109_RS19005	COG0750	zinc metalloprotease
ANAE109_RS19020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ANAE109_RS19045	COG1758	RNA polymerase activity
ANAE109_RS19060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ANAE109_RS19065	COG0459	protein refolding
ANAE109_RS19090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANAE109_RS19100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ANAE109_RS19105	COG0045	succinate-CoA ligase (ADP-forming) activity
ANAE109_RS19155	COG1380	Effector of murein hydrolase LrgA
ANAE109_RS19160	COG1346	cytolysis
ANAE109_RS19205	COG1183	phosphatidylcholine synthase activity
ANAE109_RS19215	COG1058	Belongs to the CinA family
ANAE109_RS19215	COG1546	Belongs to the CinA family
ANAE109_RS19260	COG0702	epimerase
ANAE109_RS19280	COG1100	Small GTP-binding protein
ANAE109_RS19290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ANAE109_RS19295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ANAE109_RS19300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ANAE109_RS19315	COG0590	tRNA wobble adenosine to inosine editing
ANAE109_RS19330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ANAE109_RS19335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ANAE109_RS19335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANAE109_RS19345	COG0585	pseudouridine synthase activity
ANAE109_RS19360	COG2261	transglycosylase associated protein
ANAE109_RS19400	COG0651	ATP synthesis coupled electron transport
ANAE109_RS19405	COG0651	ATP synthesis coupled electron transport
ANAE109_RS19420	COG0651	ATP synthesis coupled electron transport
ANAE109_RS19425	COG0649	NAD binding
ANAE109_RS19430	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ANAE109_RS19455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ANAE109_RS19460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ANAE109_RS19490	COG0739	heme binding
ANAE109_RS19510	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ANAE109_RS19530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ANAE109_RS19535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ANAE109_RS19540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ANAE109_RS19545	COG1428	Deoxynucleoside kinase
ANAE109_RS19560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ANAE109_RS19565	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS19570	COG0484	heat shock protein binding
ANAE109_RS19585	COG0631	protein serine/threonine phosphatase activity
ANAE109_RS19590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ANAE109_RS19640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ANAE109_RS19660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ANAE109_RS19685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ANAE109_RS19690	COG0840	transmembrane signaling receptor activity
ANAE109_RS19705	COG1902	pentaerythritol trinitrate reductase activity
ANAE109_RS19735	COG0477	Major facilitator Superfamily
ANAE109_RS19740	COG0626	cystathionine gamma-synthase activity
ANAE109_RS19760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANAE109_RS19770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ANAE109_RS19780	COG5002	protein histidine kinase activity
ANAE109_RS19790	COG2267	carboxylic ester hydrolase activity
ANAE109_RS19795	COG2226	methyltransferase
ANAE109_RS19800	COG4191	Histidine kinase
ANAE109_RS19810	COG0515	serine threonine protein kinase
ANAE109_RS19825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ANAE109_RS19830	COG3437	response regulator, receiver
ANAE109_RS19845	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ANAE109_RS19870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ANAE109_RS19890	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS19895	COG2001	Belongs to the MraZ family
ANAE109_RS19905	COG0275	rRNA processing
ANAE109_RS19920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ANAE109_RS19925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ANAE109_RS19930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANAE109_RS19935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ANAE109_RS19945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ANAE109_RS19950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ANAE109_RS19955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ANAE109_RS19960	COG1181	Belongs to the D-alanine--D-alanine ligase family
ANAE109_RS19980	COG2132	Multicopper oxidase
ANAE109_RS19995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ANAE109_RS20045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ANAE109_RS20060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ANAE109_RS20065	COG1388	LysM domain
ANAE109_RS20065	COG1705	Flagellar rod assembly protein muramidase FlgJ
ANAE109_RS20070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ANAE109_RS20105	COG0793	Belongs to the peptidase S41A family
ANAE109_RS20120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ANAE109_RS20150	COG2027	D-alanyl-D-alanine carboxypeptidase
ANAE109_RS20160	COG2226	methyltransferase
ANAE109_RS20190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ANAE109_RS20195	COG2003	Belongs to the UPF0758 family
ANAE109_RS20200	COG2003	Belongs to the UPF0758 family
ANAE109_RS20215	COG2353	YceI-like domain
ANAE109_RS20225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ANAE109_RS20230	COG2171	N-acyltransferase activity
ANAE109_RS20235	COG0436	Aminotransferase
ANAE109_RS20240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ANAE109_RS20255	COG1192	Involved in chromosome partitioning
ANAE109_RS20280	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ANAE109_RS20285	COG0047	phosphoribosylformylglycinamidine synthase activity
ANAE109_RS20295	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS20300	COG0312	modulator of DNA gyrase
ANAE109_RS20305	COG0312	modulator of DNA gyrase
ANAE109_RS20360	COG4964	Belongs to the GSP D family
ANAE109_RS20390	COG4221	oxidoreductase activity
ANAE109_RS20405	COG1595	DNA-templated transcription, initiation
ANAE109_RS20410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ANAE109_RS20480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANAE109_RS20495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANAE109_RS20565	COG1074	ATP-dependent DNA helicase activity
ANAE109_RS20625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ANAE109_RS20650	COG3459	Glycosyltransferase 36 associated
ANAE109_RS20675	COG0840	transmembrane signaling receptor activity
ANAE109_RS20695	COG1940	carbohydrate kinase activity
ANAE109_RS20710	COG1793	dna ligase
ANAE109_RS20720	COG3118	belongs to the thioredoxin family
ANAE109_RS20730	COG1278	Cold shock
ANAE109_RS20750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANAE109_RS20755	COG0829	nickel cation binding
ANAE109_RS20760	COG0832	Belongs to the urease beta subunit family
ANAE109_RS20760	COG0831	urea catabolic process
ANAE109_RS20765	COG0804	urea catabolic process
ANAE109_RS20770	COG0830	nickel cation binding
ANAE109_RS20775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ANAE109_RS20780	COG2818	Glycosylase
ANAE109_RS20790	COG2205	protein histidine kinase activity
ANAE109_RS20795	COG0730	response to heat
ANAE109_RS20805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ANAE109_RS20825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ANAE109_RS20840	COG0488	(ABC) transporter
ANAE109_RS20875	COG0589	response to stress
ANAE109_RS20880	COG2032	superoxide dismutase activity
ANAE109_RS20895	COG2193	ferroxidase activity
ANAE109_RS20900	COG1472	Belongs to the glycosyl hydrolase 3 family
ANAE109_RS20905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ANAE109_RS20930	COG1657	PFAM Prenyltransferase squalene oxidase
ANAE109_RS20935	COG1562	ergosterol biosynthetic process
ANAE109_RS20940	COG3573	Dehydrogenase
ANAE109_RS20945	COG1304	FMN binding
ANAE109_RS20955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANAE109_RS20970	COG1295	ribonuclease BN
ANAE109_RS20970	COG1959	2 iron, 2 sulfur cluster binding
ANAE109_RS20990	COG1560	Kdo2-lipid A biosynthetic process
ANAE109_RS21005	COG0439	Biotin carboxylase
ANAE109_RS21010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ANAE109_RS21065	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ANAE109_RS21065	COG1918	ferrous iron import across plasma membrane
ANAE109_RS21070	COG1918	ferrous iron import across plasma membrane
ANAE109_RS21070	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ANAE109_RS21095	COG0437	4 iron, 4 sulfur cluster binding
ANAE109_RS21130	COG1278	Cold shock
ANAE109_RS21155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ANAE109_RS21165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ANAE109_RS21180	COG0785	Cytochrome C biogenesis protein
ANAE109_RS21190	COG0508	dehydrogenase complex catalyzes the overall conversion of
ANAE109_RS21195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ANAE109_RS21250	COG0708	Exodeoxyribonuclease III
ANAE109_RS21270	COG1846	Transcriptional regulator
ANAE109_RS21295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ANAE109_RS21310	COG3852	Histidine kinase
ANAE109_RS21335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ANAE109_RS21355	COG5002	protein histidine kinase activity
ANAE109_RS21365	COG1024	Enoyl-CoA hydratase
ANAE109_RS21365	COG1250	3-hydroxyacyl-CoA dehydrogenase
ANAE109_RS21370	COG0183	Belongs to the thiolase family
ANAE109_RS21385	COG1131	(ABC) transporter
ANAE109_RS21400	COG1234	tRNA 3'-trailer cleavage
ANAE109_RS21420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ANAE109_RS21425	COG0515	serine threonine protein kinase
ANAE109_RS21425	COG2815	serine threonine protein kinase
ANAE109_RS21470	COG0318	PFAM AMP-dependent synthetase and ligase
ANAE109_RS21475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ANAE109_RS21490	COG0542	response to heat
ANAE109_RS21530	COG0142	geranyltranstransferase activity
ANAE109_RS21550	COG0463	Glycosyl transferase, family 2
ANAE109_RS21575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ANAE109_RS21580	COG2226	methyltransferase
ANAE109_RS21585	COG0163	prenyltransferase activity
ANAE109_RS21590	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ANAE109_RS21595	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ANAE109_RS21600	COG0402	S-adenosylhomocysteine deaminase activity
ANAE109_RS21615	COG5002	protein histidine kinase activity
ANAE109_RS21620	COG1228	amidohydrolase
ANAE109_RS21625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ANAE109_RS21630	COG2890	protein-(glutamine-N5) methyltransferase activity
ANAE109_RS21635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ANAE109_RS21640	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ANAE109_RS21710	COG0464	growth
ANAE109_RS21735	COG2226	methyltransferase
ANAE109_RS21740	COG1966	Carbon starvation protein
ANAE109_RS21760	COG0644	oxidoreductase
ANAE109_RS21765	COG0492	ferredoxin-NADP+ reductase activity
ANAE109_RS21785	COG0531	amino acid
ANAE109_RS21815	COG5002	protein histidine kinase activity
ANAE109_RS21820	COG2205	protein histidine kinase activity
ANAE109_RS21825	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS21830	COG4733	cellulase activity
ANAE109_RS21830	COG5297	Belongs to the glycosyl hydrolase family 6
ANAE109_RS21835	COG2839	Protein conserved in bacteria
ANAE109_RS21845	COG3300	MHYT domain
ANAE109_RS21845	COG5001	Diguanylate cyclase
ANAE109_RS21850	COG2204	response regulator
ANAE109_RS21855	COG2205	protein histidine kinase activity
ANAE109_RS21885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ANAE109_RS21900	COG2132	Multicopper oxidase
ANAE109_RS21915	COG0129	dihydroxy-acid dehydratase activity
ANAE109_RS21960	COG1960	acyl-CoA dehydrogenase activity
ANAE109_RS22005	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS22030	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS22060	COG1136	(ABC) transporter
ANAE109_RS22060	COG0577	efflux transmembrane transporter activity
ANAE109_RS22070	COG0577	efflux transmembrane transporter activity
ANAE109_RS22070	COG1136	(ABC) transporter
ANAE109_RS22075	COG0681	Belongs to the peptidase S26 family
ANAE109_RS22085	COG1793	dna ligase
ANAE109_RS22090	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ANAE109_RS22110	COG3259	Nickel-dependent hydrogenase
ANAE109_RS22130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ANAE109_RS22135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ANAE109_RS22160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ANAE109_RS22165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ANAE109_RS22170	COG0504	CTP synthase activity
ANAE109_RS22175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ANAE109_RS22185	COG0564	pseudouridine synthase activity
ANAE109_RS22195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ANAE109_RS22205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ANAE109_RS22210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ANAE109_RS22215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ANAE109_RS22250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ANAE109_RS22260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANAE109_RS22275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ANAE109_RS22295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ANAE109_RS22310	COG0713	ATP synthesis coupled electron transport
ANAE109_RS22315	COG0839	Belongs to the complex I subunit 6 family
ANAE109_RS22325	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ANAE109_RS22330	COG2201	protein-glutamate methylesterase activity
ANAE109_RS22350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ANAE109_RS22385	COG0784	Response regulator, receiver
ANAE109_RS22385	COG2205	protein histidine kinase activity
ANAE109_RS22390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ANAE109_RS22415	COG1393	Belongs to the ArsC family
ANAE109_RS22430	COG1193	negative regulation of DNA recombination
ANAE109_RS22435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ANAE109_RS22465	COG5002	protein histidine kinase activity
ANAE109_RS22475	COG0306	phosphate transporter
ANAE109_RS22480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ANAE109_RS22485	COG2094	Belongs to the DNA glycosylase MPG family
ANAE109_RS22500	COG0469	pyruvate kinase activity
ANAE109_RS22510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ANAE109_RS22540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ANAE109_RS22560	COG2205	protein histidine kinase activity
ANAE109_RS22575	COG4191	Histidine kinase
ANAE109_RS22580	COG2204	response regulator
ANAE109_RS22585	COG0174	glutamine synthetase
ANAE109_RS22600	COG2046	Belongs to the sulfate adenylyltransferase family
ANAE109_RS22605	COG1028	Short-chain dehydrogenase reductase Sdr
ANAE109_RS22625	COG1595	DNA-templated transcription, initiation
ANAE109_RS22635	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ANAE109_RS22650	COG0411	ABC transporter
ANAE109_RS22660	COG0559	Belongs to the binding-protein-dependent transport system permease family
ANAE109_RS22670	COG0745	RESPONSE REGULATOR receiver
ANAE109_RS22680	COG1472	Belongs to the glycosyl hydrolase 3 family
ANAE109_RS22695	COG0714	Associated with various cellular activities
ANAE109_RS22710	COG1595	DNA-templated transcription, initiation
ANAE109_RS22725	COG0489	protein tyrosine kinase activity
ANAE109_RS22725	COG3206	protein involved in exopolysaccharide biosynthesis
ANAE109_RS22740	COG1132	(ABC) transporter
ANAE109_RS22750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ANAE109_RS22760	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS22765	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS22775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ANAE109_RS22780	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ANAE109_RS22795	COG0463	Glycosyl transferase, family 2
ANAE109_RS22830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ANAE109_RS22835	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ANAE109_RS22860	COG3852	Histidine kinase
ANAE109_RS22865	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ANAE109_RS22870	COG1691	(AIR) carboxylase
ANAE109_RS22880	COG2198	Histidine kinase
ANAE109_RS22880	COG0643	Histidine kinase
ANAE109_RS22885	COG2201	protein-glutamate methylesterase activity
ANAE109_RS22890	COG0835	chemotaxis
ANAE109_RS22905	COG2202	Pas domain
ANAE109_RS22905	COG2205	protein histidine kinase activity
ANAE109_RS22910	COG1100	Small GTP-binding protein
ANAE109_RS22915	COG1199	ATP-dependent helicase activity
ANAE109_RS22940	COG0484	heat shock protein binding
ANAE109_RS22945	COG0443	Heat shock 70 kDa protein
ANAE109_RS22950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ANAE109_RS22955	COG1420	regulation of RNA biosynthetic process
ANAE109_RS22970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANAE109_RS22975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANAE109_RS22980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ANAE109_RS22985	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ANAE109_RS22995	COG0012	GTP binding
ANAE109_RS23000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ANAE109_RS23005	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ANAE109_RS23010	COG0356	it plays a direct role in the translocation of protons across the membrane
ANAE109_RS23030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ANAE109_RS23045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ANAE109_RS23050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ANAE109_RS23055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ANAE109_RS23060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ANAE109_RS23065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ANAE109_RS23070	COG0071	Belongs to the small heat shock protein (HSP20) family
ANAE109_RS23080	COG1475	DNA binding
ANAE109_RS23085	COG1192	Involved in chromosome partitioning
ANAE109_RS23095	COG0357	Ribosomal RNA small subunit methyltransferase G
ANAE109_RS23110	COG0706	membrane insertase activity
ANAE109_RS23115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ANAE109_RS23120	COG0594	ribonuclease P activity
ANAE109_RS23145	COG2205	protein histidine kinase activity
ANAE109_RS23160	COG2205	protein histidine kinase activity
ANAE109_RS23190	COG0457	Tetratricopeptide repeat
ANAE109_RS23190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ANAE109_RS23200	COG2205	protein histidine kinase activity
ANAE109_RS23210	COG4968	Prepilin-type N-terminal cleavage methylation domain
ANAE109_RS23320	COG4585	Histidine kinase
ANAE109_RS23340	COG2204	response regulator
ANAE109_RS23355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ANAE109_RS23355	COG0723	plastoquinol--plastocyanin reductase activity
ANAE109_RS23385	COG1215	transferase activity, transferring glycosyl groups
ANAE109_RS23405	COG1187	pseudouridine synthase activity
ANAE109_RS23415	COG0419	ATPase involved in DNA repair
ANAE109_RS23420	COG2205	protein histidine kinase activity
ANAE109_RS23425	COG5002	protein histidine kinase activity
ANAE109_RS23430	COG0343	queuine tRNA-ribosyltransferase activity
ANAE109_RS23435	COG1426	Protein conserved in bacteria
ANAE109_RS23440	COG3258	Cytochrome c
ANAE109_RS23465	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS23470	COG0438	transferase activity, transferring glycosyl groups
ANAE109_RS23505	COG2010	Cytochrome c
ANAE109_RS23525	COG1845	cytochrome c oxidase, subunit III
ANAE109_RS23555	COG2205	protein histidine kinase activity
ANAE109_RS23585	COG3227	Zinc metalloprotease (Elastase)
ANAE109_RS23630	COG4251	negative regulation of phosphorylation
ANAE109_RS23635	COG2205	protein histidine kinase activity
ANAE109_RS23715	COG2205	protein histidine kinase activity
ANAE109_RS23715	COG0784	Response regulator, receiver
ANAE109_RS23755	COG0582	viral genome integration into host DNA
ANAE109_RS23760	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
ANAE109_RS23775	COG0653	protein targeting
ANAE109_RS23780	COG2815	serine threonine protein kinase
ANAE109_RS23780	COG0515	serine threonine protein kinase
ANAE109_RS23790	COG0501	Belongs to the peptidase M48B family
ANAE109_RS23825	COG3604	Transcriptional regulator
ANAE109_RS23835	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ANAE109_RS23845	COG5002	protein histidine kinase activity