locus-tag	class	description
DO83_RS00060	COG0534	Mate efflux family protein
DO83_RS00085	COG0196	riboflavin kinase activity
DO83_RS00090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DO83_RS00095	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DO83_RS00100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DO83_RS00105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DO83_RS00115	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DO83_RS00120	COG0195	Participates in both transcription termination and antitermination
DO83_RS00135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DO83_RS00140	COG0750	zinc metalloprotease
DO83_RS00150	COG4589	Belongs to the CDS family
DO83_RS00160	COG0233	cytoplasmic translational termination
DO83_RS00165	COG0528	UMP kinase activity
DO83_RS00180	COG1924	4 iron, 4 sulfur cluster binding
DO83_RS00200	COG1490	D-aminoacyl-tRNA deacylase activity
DO83_RS00210	COG0440	acetolactate synthase activity
DO83_RS00225	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DO83_RS00230	COG0187	DNA topoisomerase II activity
DO83_RS00255	COG0745	RESPONSE REGULATOR receiver
DO83_RS00270	COG0419	ATPase involved in DNA repair
DO83_RS00275	COG0420	3'-5' exonuclease activity
DO83_RS00280	COG0750	zinc metalloprotease
DO83_RS00285	COG0497	DNA recombination
DO83_RS00290	COG1438	arginine binding
DO83_RS00295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DO83_RS00300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DO83_RS00305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DO83_RS00315	COG1722	exodeoxyribonuclease VII activity
DO83_RS00320	COG1570	exodeoxyribonuclease VII activity
DO83_RS00325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DO83_RS00330	COG1302	Protein conserved in bacteria
DO83_RS00340	COG4145	pantothenate transmembrane transporter activity
DO83_RS00430	COG1131	(ABC) transporter
DO83_RS00445	COG5002	protein histidine kinase activity
DO83_RS00475	COG0534	Mate efflux family protein
DO83_RS00490	COG5002	protein histidine kinase activity
DO83_RS00495	COG0745	RESPONSE REGULATOR receiver
DO83_RS00500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_RS00510	COG0372	Belongs to the citrate synthase family
DO83_RS00515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_RS00520	COG2357	RelA SpoT domain protein
DO83_RS00525	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DO83_RS00545	COG1475	DNA binding
DO83_RS00555	COG1475	DNA binding
DO83_RS00570	COG0656	L-ascorbic acid biosynthetic process
DO83_RS00585	COG0789	Transcriptional regulator
DO83_RS00625	COG0217	transcriptional regulatory protein
DO83_RS00635	COG2337	Toxic component of a toxin-antitoxin (TA) module
DO83_RS00640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DO83_RS00645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DO83_RS00645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DO83_RS00650	COG0736	holo-[acyl-carrier-protein] synthase activity
DO83_RS00655	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DO83_RS00660	COG0488	(ABC) transporter
DO83_RS00665	COG1215	transferase activity, transferring glycosyl groups
DO83_RS00675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DO83_RS00680	COG0481	GTPase activity
DO83_RS00690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DO83_RS00695	COG0268	Binds directly to 16S ribosomal RNA
DO83_RS00700	COG1466	dna polymerase III delta subunit
DO83_RS00705	COG2333	competence protein COMEC
DO83_RS00705	COG0658	competence protein
DO83_RS00715	COG5002	protein histidine kinase activity
DO83_RS00720	COG0745	RESPONSE REGULATOR receiver
DO83_RS00735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DO83_RS00740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DO83_RS00745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DO83_RS00750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DO83_RS00780	COG0165	Argininosuccinate lyase
DO83_RS00800	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DO83_RS00810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DO83_RS00840	COG0484	heat shock protein binding
DO83_RS00845	COG0443	Heat shock 70 kDa protein
DO83_RS00850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DO83_RS00855	COG1420	regulation of RNA biosynthetic process
DO83_RS00870	COG1349	DNA-binding transcription factor activity
DO83_RS00880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DO83_RS00885	COG1882	Formate acetyltransferase
DO83_RS00895	COG0640	Transcriptional regulator
DO83_RS00900	COG0561	phosphatase activity
DO83_RS00925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DO83_RS00940	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DO83_RS00945	COG0237	dephospho-CoA kinase activity
DO83_RS00950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DO83_RS00950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DO83_RS00960	COG1959	2 iron, 2 sulfur cluster binding
DO83_RS00970	COG0494	nUDIX hydrolase
DO83_RS00985	COG0628	permease
DO83_RS01000	COG0493	'glutamate synthase
DO83_RS01010	COG0534	Mate efflux family protein
DO83_RS01030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DO83_RS01035	COG0302	gtp cyclohydrolase
DO83_RS01040	COG0602	queuosine metabolic process
DO83_RS01045	COG0720	synthase
DO83_RS01050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS01050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS01050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS01060	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
DO83_RS01075	COG3177	Filamentation induced by cAMP protein fic
DO83_RS01090	COG0583	DNA-binding transcription factor activity
DO83_RS01135	COG0363	glucosamine-6-phosphate deaminase activity
DO83_RS01140	COG1737	Transcriptional regulator
DO83_RS01145	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DO83_RS01155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DO83_RS01165	COG2384	SAM-dependent methyltransferase
DO83_RS01170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DO83_RS01175	COG0358	DNA primase activity
DO83_RS01180	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DO83_RS01185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DO83_RS01190	COG1968	undecaprenyl-diphosphatase activity
DO83_RS01195	COG1758	RNA polymerase activity
DO83_RS01200	COG0194	GDP metabolic process
DO83_RS01205	COG1561	YicC-like family, N-terminal region
DO83_RS01215	COG0564	pseudouridine synthase activity
DO83_RS01220	COG4221	oxidoreductase activity
DO83_RS01225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DO83_RS01230	COG1187	pseudouridine synthase activity
DO83_RS01235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DO83_RS01235	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DO83_RS01240	COG2357	RelA SpoT domain protein
DO83_RS01245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DO83_RS01250	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DO83_RS01270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DO83_RS01280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DO83_RS01285	COG1160	GTP binding
DO83_RS01290	COG1496	oxidoreductase activity
DO83_RS01295	COG0792	nuclease activity
DO83_RS01300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DO83_RS01305	COG0681	Belongs to the peptidase S26 family
DO83_RS01320	COG0335	large ribosomal subunit rRNA binding
DO83_RS01325	COG0561	phosphatase activity
DO83_RS01330	COG0336	Belongs to the RNA methyltransferase TrmD family
DO83_RS01335	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DO83_RS01340	COG2195	Cleaves the N-terminal amino acid of tripeptides
DO83_RS01355	COG1297	OPT oligopeptide transporter protein
DO83_RS01390	COG0297	glycogen (starch) synthase activity
DO83_RS01400	COG4824	toxin secretion phage lysis holin
DO83_RS01415	COG4974	Belongs to the 'phage' integrase family
DO83_RS01520	COG5484	DNA packaging
DO83_RS01520	COG3728	DNA packaging
DO83_RS01695	COG2226	methyltransferase
DO83_RS01725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DO83_RS01730	COG0557	exoribonuclease II activity
DO83_RS01740	COG0148	phosphopyruvate hydratase activity
DO83_RS01790	COG0534	Mate efflux family protein
DO83_RS01810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DO83_RS01825	COG0149	triose-phosphate isomerase activity
DO83_RS01845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DO83_RS01855	COG0791	NLP P60 protein
DO83_RS01855	COG0741	lytic transglycosylase activity
DO83_RS01915	COG1854	S-ribosylhomocysteine lyase activity
DO83_RS01935	COG1837	Belongs to the UPF0109 family
DO83_RS01940	COG0228	four-way junction DNA binding
DO83_RS01945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DO83_RS01955	COG0488	(ABC) transporter
DO83_RS01960	COG0037	tRNA processing
DO83_RS01970	COG5002	protein histidine kinase activity
DO83_RS01975	COG0745	RESPONSE REGULATOR receiver
DO83_RS01990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DO83_RS01995	COG1546	Belongs to the CinA family
DO83_RS01995	COG1058	Belongs to the CinA family
DO83_RS02005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DO83_RS02030	COG0740	serine-type endopeptidase activity
DO83_RS02035	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DO83_RS02045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DO83_RS02050	COG2081	HI0933 family
DO83_RS02065	COG0673	inositol 2-dehydrogenase activity
DO83_RS02070	COG0667	Aldo Keto reductase
DO83_RS02075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DO83_RS02080	COG0534	Mate efflux family protein
DO83_RS02085	COG0791	NLP P60 protein
DO83_RS02085	COG3883	PFAM NLP P60 protein
DO83_RS02125	COG0733	neurotransmitter:sodium symporter activity
DO83_RS02135	COG3655	Transcriptional regulator
DO83_RS02150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DO83_RS02165	COG2190	(PTS) system
DO83_RS02165	COG1263	PTS System
DO83_RS02165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS02170	COG1482	cell wall glycoprotein biosynthetic process
DO83_RS02180	COG3716	PTS system mannose fructose sorbose family IID component
DO83_RS02185	COG3715	PTS system
DO83_RS02195	COG3711	transcriptional antiterminator
DO83_RS02200	COG1295	ribonuclease BN
DO83_RS02205	COG0205	6-phosphofructokinase activity
DO83_RS02210	COG0006	proline dipeptidase activity
DO83_RS02215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DO83_RS02220	COG1191	sigma factor activity
DO83_RS02235	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DO83_RS02250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DO83_RS02255	COG2226	methyltransferase
DO83_RS02260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_RS02265	COG0352	thiamine-phosphate diphosphorylase activity
DO83_RS02275	COG1074	ATP-dependent DNA helicase activity
DO83_RS02280	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DO83_RS02295	COG2011	ABC-type metal ion transport system permease component
DO83_RS02300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DO83_RS02305	COG1464	Belongs to the NlpA lipoprotein family
DO83_RS02410	COG0210	DNA helicase
DO83_RS02420	COG4496	protein, YerC YecD
DO83_RS02425	COG1115	amino acid carrier protein
DO83_RS02430	COG0733	neurotransmitter:sodium symporter activity
DO83_RS02435	COG0151	Belongs to the GarS family
DO83_RS02440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DO83_RS02445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DO83_RS02455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DO83_RS02485	COG0167	dihydroorotate dehydrogenase activity
DO83_RS02490	COG0543	2 iron, 2 sulfur cluster binding
DO83_RS02495	COG0284	orotidine-5'-phosphate decarboxylase activity
DO83_RS02515	COG2022	thiamine diphosphate biosynthetic process
DO83_RS02575	COG0791	NLP P60 protein
DO83_RS02665	COG0582	viral genome integration into host DNA
DO83_RS02675	COG1598	PFAM Uncharacterised protein family UPF0150
DO83_RS02710	COG1192	Involved in chromosome partitioning
DO83_RS02810	COG1346	cytolysis
DO83_RS02845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DO83_RS02855	COG0215	cysteine-tRNA ligase activity
DO83_RS02860	COG1045	serine acetyltransferase
DO83_RS02865	COG1268	BioY protein
DO83_RS02875	COG0110	maltose O-acetyltransferase activity
DO83_RS02910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DO83_RS02915	COG1410	methionine synthase
DO83_RS02915	COG0646	methionine synthase
DO83_RS02925	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DO83_RS02930	COG1739	Uncharacterized protein family UPF0029
DO83_RS02950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DO83_RS02980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DO83_RS03020	COG0726	polysaccharide deacetylase
DO83_RS03025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DO83_RS03030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS03030	COG1263	PTS System
DO83_RS03035	COG2190	(PTS) system
DO83_RS03035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS03035	COG1263	PTS System
DO83_RS03040	COG3711	transcriptional antiterminator
DO83_RS03090	COG2226	methyltransferase
DO83_RS03100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DO83_RS03105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DO83_RS03110	COG0066	3-isopropylmalate dehydratase activity
DO83_RS03115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DO83_RS03120	COG0066	3-isopropylmalate dehydratase activity
DO83_RS03140	COG0569	domain protein
DO83_RS03145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DO83_RS03150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DO83_RS03165	COG3775	system Galactitol-specific IIC component
DO83_RS03175	COG3711	transcriptional antiterminator
DO83_RS03180	COG2357	RelA SpoT domain protein
DO83_RS03185	COG0730	response to heat
DO83_RS03195	COG3546	catalase activity
DO83_RS03220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DO83_RS03225	COG1983	PspC domain protein
DO83_RS03245	COG1649	PFAM Uncharacterised BCR, COG1649
DO83_RS03260	COG0287	Prephenate dehydrogenase
DO83_RS03265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DO83_RS03275	COG1362	aminopeptidase activity
DO83_RS03290	COG1349	DNA-binding transcription factor activity
DO83_RS03300	COG0673	inositol 2-dehydrogenase activity
DO83_RS03305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DO83_RS03330	COG3962	Belongs to the TPP enzyme family
DO83_RS03335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DO83_RS03340	COG1609	Transcriptional regulator
DO83_RS03345	COG1349	DNA-binding transcription factor activity
DO83_RS03355	COG1082	Xylose isomerase domain protein TIM barrel
DO83_RS03360	COG1082	Xylose isomerase domain protein TIM barrel
DO83_RS03375	COG0673	inositol 2-dehydrogenase activity
DO83_RS03400	COG1082	Xylose isomerase domain protein TIM barrel
DO83_RS03410	COG0673	inositol 2-dehydrogenase activity
DO83_RS03420	COG1846	Transcriptional regulator
DO83_RS03425	COG1960	acyl-CoA dehydrogenase activity
DO83_RS03430	COG1024	Enoyl-CoA hydratase
DO83_RS03440	COG2610	gluconate transmembrane transporter activity
DO83_RS03445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DO83_RS03450	COG2086	electron transfer activity
DO83_RS03455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DO83_RS03460	COG2086	electron transfer activity
DO83_RS03465	COG1960	acyl-CoA dehydrogenase activity
DO83_RS03475	COG1621	beta-fructofuranosidase activity
DO83_RS03480	COG1263	PTS System
DO83_RS03480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS03480	COG2190	(PTS) system
DO83_RS03485	COG1609	Transcriptional regulator
DO83_RS03490	COG4717	serine-type aminopeptidase activity
DO83_RS03495	COG0420	3'-5' exonuclease activity
DO83_RS03520	COG1132	(ABC) transporter
DO83_RS03545	COG1216	Glycosyl transferase, family 2
DO83_RS03660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DO83_RS03725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DO83_RS03730	COG0436	Aminotransferase
DO83_RS03760	COG1115	amino acid carrier protein
DO83_RS03765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DO83_RS03770	COG1121	(ABC) transporter
DO83_RS03775	COG0803	Belongs to the bacterial solute-binding protein 9 family
DO83_RS03795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DO83_RS03800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DO83_RS03810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DO83_RS03810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DO83_RS03835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DO83_RS03840	COG0561	phosphatase activity
DO83_RS03845	COG0372	Belongs to the citrate synthase family
DO83_RS03850	COG1846	Transcriptional regulator
DO83_RS03855	COG0587	DNA-directed DNA polymerase activity
DO83_RS03865	COG0445	tRNA wobble uridine modification
DO83_RS03885	COG1683	Conserved Protein
DO83_RS03895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DO83_RS03900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DO83_RS03905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DO83_RS03925	COG1115	amino acid carrier protein
DO83_RS03935	COG1132	(ABC) transporter
DO83_RS03950	COG0653	protein targeting
DO83_RS03960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DO83_RS03975	COG1609	Transcriptional regulator
DO83_RS03995	COG0523	cobalamin synthesis protein
DO83_RS04000	COG0371	Dehydrogenase
DO83_RS04025	COG0561	phosphatase activity
DO83_RS04035	COG1595	DNA-templated transcription, initiation
DO83_RS04050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DO83_RS04060	COG1621	beta-fructofuranosidase activity
DO83_RS04065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS04065	COG1263	PTS System
DO83_RS04070	COG1621	beta-fructofuranosidase activity
DO83_RS04075	COG1609	Transcriptional regulator
DO83_RS04100	COG0515	serine threonine protein kinase
DO83_RS04100	COG2815	serine threonine protein kinase
DO83_RS04105	COG0631	protein serine/threonine phosphatase activity
DO83_RS04110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DO83_RS04115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DO83_RS04115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DO83_RS04120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DO83_RS04125	COG0242	peptide deformylase activity
DO83_RS04130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DO83_RS04135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DO83_RS04145	COG3958	Transketolase
DO83_RS04150	COG3959	Transketolase, thiamine diphosphate binding domain
DO83_RS04160	COG1609	Transcriptional regulator
DO83_RS04170	COG0538	isocitrate dehydrogenase activity
DO83_RS04175	COG2188	Transcriptional regulator
DO83_RS04180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DO83_RS04185	COG2140	Oxalate decarboxylase
DO83_RS04210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DO83_RS04235	COG0463	Glycosyl transferase, family 2
DO83_RS04235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DO83_RS04245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DO83_RS04265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DO83_RS04265	COG0463	Glycosyl transferase, family 2
DO83_RS04270	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DO83_RS04295	COG0463	Glycosyl transferase, family 2
DO83_RS04315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DO83_RS04325	COG0562	UDP-galactopyranose mutase
DO83_RS04355	COG2244	polysaccharide biosynthetic process
DO83_RS04365	COG0438	transferase activity, transferring glycosyl groups
DO83_RS04370	COG1442	glycosyl transferase family 8
DO83_RS04370	COG1216	Glycosyl transferase, family 2
DO83_RS04375	COG1215	transferase activity, transferring glycosyl groups
DO83_RS04380	COG1215	transferase activity, transferring glycosyl groups
DO83_RS04385	COG0110	maltose O-acetyltransferase activity
DO83_RS04405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DO83_RS04445	COG2246	polysaccharide biosynthetic process
DO83_RS04450	COG0463	Glycosyl transferase, family 2
DO83_RS04460	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DO83_RS04475	COG1773	rubredoxin
DO83_RS04475	COG1592	Rubrerythrin
DO83_RS04485	COG0277	FAD linked oxidase domain protein
DO83_RS04495	COG2086	electron transfer activity
DO83_RS04500	COG2186	Transcriptional regulator
DO83_RS04520	COG2385	sporulation resulting in formation of a cellular spore
DO83_RS04530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DO83_RS04560	COG0745	RESPONSE REGULATOR receiver
DO83_RS04565	COG5002	protein histidine kinase activity
DO83_RS04570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DO83_RS04580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DO83_RS04585	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DO83_RS04605	COG4120	Belongs to the binding-protein-dependent transport system permease family
DO83_RS04615	COG1640	4-alpha-glucanotransferase
DO83_RS04620	COG0281	malic enzyme
DO83_RS04625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DO83_RS04630	COG3959	Transketolase, thiamine diphosphate binding domain
DO83_RS04650	COG3711	transcriptional antiterminator
DO83_RS04675	COG2155	Conserved Protein
DO83_RS04700	COG1620	l-lactate permease
DO83_RS04710	COG2195	Cleaves the N-terminal amino acid of tripeptides
DO83_RS04715	COG1132	(ABC) transporter
DO83_RS04720	COG4988	ABC transporter
DO83_RS04725	COG2832	Protein of unknown function (DUF454)
DO83_RS04730	COG1120	ATPase activity
DO83_RS04805	COG0191	fructose-bisphosphate aldolase activity
DO83_RS04825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS04830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS04830	COG3711	transcriptional antiterminator
DO83_RS04850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DO83_RS04855	COG0776	regulation of translation
DO83_RS04860	COG2996	Protein conserved in bacteria
DO83_RS04875	COG4509	Sortase family
DO83_RS04885	COG1321	iron dependent repressor
DO83_RS04890	COG2608	mercury ion transmembrane transporter activity
DO83_RS04930	COG0443	Heat shock 70 kDa protein
DO83_RS04950	COG0768	penicillin binding
DO83_RS04955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DO83_RS04965	COG0628	permease
DO83_RS04970	COG0488	(ABC) transporter
DO83_RS04980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DO83_RS05005	COG1136	(ABC) transporter
DO83_RS05005	COG0577	efflux transmembrane transporter activity
DO83_RS05035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DO83_RS05040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DO83_RS05045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DO83_RS05050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DO83_RS05055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DO83_RS05060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DO83_RS05065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DO83_RS05085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DO83_RS05105	COG1131	(ABC) transporter
DO83_RS05125	COG2801	Transposase and inactivated derivatives
DO83_RS05145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DO83_RS05150	COG1609	Transcriptional regulator
DO83_RS05155	COG1414	Transcriptional regulator
DO83_RS05160	COG1607	acyl-coa hydrolase
DO83_RS05170	COG0493	'glutamate synthase
DO83_RS05200	COG4978	Transcriptional regulator
DO83_RS05200	COG0789	Transcriptional regulator
DO83_RS05210	COG1607	acyl-coa hydrolase
DO83_RS05215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DO83_RS05220	COG1960	acyl-CoA dehydrogenase activity
DO83_RS05225	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DO83_RS05230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DO83_RS05235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DO83_RS05240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DO83_RS05250	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DO83_RS05255	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DO83_RS05260	COG0356	it plays a direct role in the translocation of protons across the membrane
DO83_RS05265	COG0698	ribose 5-phosphate isomerase
DO83_RS05270	COG0009	L-threonylcarbamoyladenylate synthase
DO83_RS05275	COG0860	N-Acetylmuramoyl-L-alanine amidase
DO83_RS05290	COG1979	alcohol dehydrogenase
DO83_RS05300	COG2376	Dihydroxyacetone kinase
DO83_RS05315	COG2376	Dihydroxyacetone kinase
DO83_RS05320	COG3775	system Galactitol-specific IIC component
DO83_RS05340	COG2768	binding domain, Protein
DO83_RS05345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DO83_RS05355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DO83_RS05365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DO83_RS05365	COG0116	Belongs to the methyltransferase superfamily
DO83_RS05380	COG1929	Belongs to the glycerate kinase type-1 family
DO83_RS05385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DO83_RS05405	COG1704	LemA family
DO83_RS05425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DO83_RS05450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DO83_RS05455	COG0049	tRNA binding
DO83_RS05460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DO83_RS05465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DO83_RS05470	COG0085	RNA polymerase activity
DO83_RS05485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DO83_RS05500	COG0733	neurotransmitter:sodium symporter activity
DO83_RS05515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DO83_RS05520	COG0222	ribosome binding
DO83_RS05530	COG0081	regulation of translation
DO83_RS05540	COG0250	Participates in transcription elongation, termination and antitermination
DO83_RS05550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DO83_RS05565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DO83_RS05570	COG5001	Diguanylate cyclase
DO83_RS05570	COG1716	ATPase activity
DO83_RS05580	COG0494	nUDIX hydrolase
DO83_RS05595	COG1132	(ABC) transporter
DO83_RS05650	COG0784	Response regulator, receiver
DO83_RS05650	COG2205	protein histidine kinase activity
DO83_RS05660	COG1115	amino acid carrier protein
DO83_RS05665	COG0534	Mate efflux family protein
DO83_RS05675	COG1151	hydroxylamine reductase activity
DO83_RS05715	COG1846	Transcriptional regulator
DO83_RS05720	COG1733	regulation of RNA biosynthetic process
DO83_RS05730	COG0656	L-ascorbic acid biosynthetic process
DO83_RS05735	COG0110	maltose O-acetyltransferase activity
DO83_RS05745	COG0789	Transcriptional regulator
DO83_RS05755	COG3620	sequence-specific DNA binding
DO83_RS05765	COG3340	Belongs to the peptidase S51 family
DO83_RS05785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DO83_RS05785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DO83_RS05840	COG0582	viral genome integration into host DNA
DO83_RS05870	COG1136	(ABC) transporter
DO83_RS05880	COG0745	RESPONSE REGULATOR receiver
DO83_RS05895	COG1136	(ABC) transporter
DO83_RS05910	COG2205	protein histidine kinase activity
DO83_RS05915	COG0745	RESPONSE REGULATOR receiver
DO83_RS05945	COG1136	(ABC) transporter
DO83_RS05955	COG0745	RESPONSE REGULATOR receiver
DO83_RS05990	COG0745	RESPONSE REGULATOR receiver
DO83_RS06005	COG2205	protein histidine kinase activity
DO83_RS06030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DO83_RS06035	COG0352	thiamine-phosphate diphosphorylase activity
DO83_RS06045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DO83_RS06105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DO83_RS06125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DO83_RS06125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DO83_RS06135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DO83_RS06145	COG0745	RESPONSE REGULATOR receiver
DO83_RS06155	COG1131	(ABC) transporter
DO83_RS06160	COG2188	Transcriptional regulator
DO83_RS06225	COG0488	(ABC) transporter
DO83_RS06305	COG2003	Belongs to the UPF0758 family
DO83_RS06370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DO83_RS06390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DO83_RS06390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DO83_RS06395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DO83_RS06415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DO83_RS06420	COG0569	domain protein
DO83_RS06425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DO83_RS06440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DO83_RS06445	COG1966	Carbon starvation protein
DO83_RS06455	COG0733	neurotransmitter:sodium symporter activity
DO83_RS06465	COG0166	Belongs to the GPI family
DO83_RS06485	COG1481	regulation of sporulation
DO83_RS06495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DO83_RS06500	COG1940	carbohydrate kinase activity
DO83_RS06505	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DO83_RS06510	COG0322	excinuclease ABC activity
DO83_RS06520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DO83_RS06520	COG1328	CTP reductase activity
DO83_RS06535	COG0697	spore germination
DO83_RS06545	COG1132	(ABC) transporter
DO83_RS06560	COG0726	polysaccharide deacetylase
DO83_RS06595	COG1802	Transcriptional regulator
DO83_RS06600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DO83_RS06605	COG5632	N-Acetylmuramoyl-L-alanine amidase
DO83_RS06605	COG3409	Peptidoglycan-binding domain 1 protein
DO83_RS06610	COG4466	Protein conserved in bacteria
DO83_RS06620	COG1349	DNA-binding transcription factor activity
DO83_RS06625	COG0667	Aldo Keto reductase
DO83_RS06630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DO83_RS06635	COG0191	fructose-bisphosphate aldolase activity
DO83_RS06640	COG1063	alcohol dehydrogenase
DO83_RS06645	COG2271	Major facilitator Superfamily
DO83_RS06650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DO83_RS06655	COG1063	alcohol dehydrogenase
DO83_RS06660	COG1028	Short-chain dehydrogenase reductase Sdr
DO83_RS06665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DO83_RS06685	COG3547	Transposase (IS116 IS110 IS902 family)
DO83_RS06690	COG1132	(ABC) transporter
DO83_RS06695	COG1132	(ABC) transporter
DO83_RS06705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DO83_RS06725	COG2040	homocysteine
DO83_RS06730	COG1115	amino acid carrier protein
DO83_RS06750	COG0534	Mate efflux family protein
DO83_RS06755	COG0673	inositol 2-dehydrogenase activity
DO83_RS06760	COG3716	PTS system mannose fructose sorbose family IID component
DO83_RS06765	COG3715	PTS system
DO83_RS06790	COG0436	Aminotransferase
DO83_RS06795	COG1522	sequence-specific DNA binding
DO83_RS06800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DO83_RS06810	COG2176	DNA-directed DNA polymerase activity
DO83_RS06815	COG0561	phosphatase activity
DO83_RS06820	COG0561	phosphatase activity
DO83_RS06825	COG1309	transcriptional regulator
DO83_RS06840	COG1136	(ABC) transporter
DO83_RS06850	COG0745	RESPONSE REGULATOR receiver
DO83_RS06860	COG3481	metal-dependent phosphohydrolase, HD sub domain
DO83_RS06865	COG1193	negative regulation of DNA recombination
DO83_RS06880	COG2199	diguanylate cyclase activity
DO83_RS06890	COG0552	protein localization to endoplasmic reticulum
DO83_RS06895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS06895	COG2190	(PTS) system
DO83_RS06895	COG1263	PTS System
DO83_RS06900	COG1737	Transcriptional regulator
DO83_RS06905	COG1737	Transcriptional regulator
DO83_RS06910	COG1263	PTS System
DO83_RS06910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS06915	COG1486	melibiose metabolic process
DO83_RS06920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DO83_RS06920	COG0519	Catalyzes the synthesis of GMP from XMP
DO83_RS06925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DO83_RS06935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DO83_RS06940	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DO83_RS06950	COG0537	adenosine 5'-monophosphoramidase activity
DO83_RS06955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DO83_RS06960	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DO83_RS06965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DO83_RS06970	COG3290	protein histidine kinase activity
DO83_RS06975	COG0705	Rhomboid family
DO83_RS06975	COG0457	Tetratricopeptide repeat
DO83_RS07035	COG4086	secreted protein
DO83_RS07050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DO83_RS07055	COG0534	Mate efflux family protein
DO83_RS07075	COG1131	(ABC) transporter
DO83_RS07080	COG1725	Transcriptional regulator
DO83_RS07095	COG1610	YqeY-like protein
DO83_RS07115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DO83_RS07135	COG0446	pyridine nucleotide-disulphide oxidoreductase
DO83_RS07140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DO83_RS07145	COG1609	Transcriptional regulator
DO83_RS07150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS07150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS07160	COG0246	Mannitol dehydrogenase
DO83_RS07165	COG3711	transcriptional antiterminator
DO83_RS07255	COG0726	polysaccharide deacetylase
DO83_RS07265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DO83_RS07275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DO83_RS07290	COG3901	Regulator of nitric oxide reductase transcription
DO83_RS07290	COG0348	domain, Protein
DO83_RS07330	COG1105	Belongs to the carbohydrate kinase PfkB family
DO83_RS07335	COG1349	DNA-binding transcription factor activity
DO83_RS07345	COG1136	(ABC) transporter
DO83_RS07350	COG0662	Cupin 2, conserved barrel domain protein
DO83_RS07355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DO83_RS07360	COG2205	protein histidine kinase activity
DO83_RS07365	COG0745	RESPONSE REGULATOR receiver
DO83_RS07370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DO83_RS07385	COG1192	Involved in chromosome partitioning
DO83_RS07390	COG0018	arginyl-trna synthetase
DO83_RS07400	COG0357	Ribosomal RNA small subunit methyltransferase G
DO83_RS07405	COG0445	tRNA wobble uridine modification
DO83_RS07410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DO83_RS07420	COG0706	membrane insertase activity
DO83_RS07425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DO83_RS07430	COG0594	ribonuclease P activity
DO83_RS07435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DO83_RS07440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DO83_RS07445	COG0592	DNA-directed DNA polymerase activity
DO83_RS07450	COG2501	S4 domain
DO83_RS07455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DO83_RS07460	COG0187	DNA topoisomerase II activity
DO83_RS07465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DO83_RS07530	COG1982	Orn Lys Arg decarboxylase major
DO83_RS07535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DO83_RS07540	COG0470	DNA polymerase III
DO83_RS07545	COG1774	PSP1 C-terminal conserved region
DO83_RS07550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DO83_RS07555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DO83_RS07560	COG2002	toxin-antitoxin pair type II binding
DO83_RS07575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DO83_RS07580	COG1846	Transcriptional regulator
DO83_RS07600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DO83_RS07605	COG0659	secondary active sulfate transmembrane transporter activity
DO83_RS07615	COG2715	membrane protein required for spore maturation
DO83_RS07630	COG0084	hydrolase, TatD family'
DO83_RS07635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DO83_RS07645	COG0590	tRNA wobble adenosine to inosine editing
DO83_RS07660	COG2357	RelA SpoT domain protein
DO83_RS07675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DO83_RS07680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DO83_RS07700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DO83_RS07705	COG2088	sporulation resulting in formation of a cellular spore
DO83_RS07715	COG0360	Binds together with S18 to 16S ribosomal RNA
DO83_RS07725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DO83_RS07735	COG0359	binds to the 23S rRNA
DO83_RS07740	COG0305	Participates in initiation and elongation during chromosome replication
DO83_RS07745	COG1040	competence protein
DO83_RS07750	COG1194	a g-specific adenine glycosylase
DO83_RS07755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DO83_RS07760	COG0765	amino acid transport
DO83_RS07830	COG1394	ATPase activity, coupled to movement of substances
DO83_RS07840	COG1737	Transcriptional regulator
DO83_RS07850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS07850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS07850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS07855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS07855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS07855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS07875	COG0038	chloride channel
DO83_RS07885	COG0494	nUDIX hydrolase
DO83_RS07900	COG0786	glutamate:sodium symporter activity
DO83_RS07910	COG0789	Transcriptional regulator
DO83_RS07915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DO83_RS07920	COG0205	6-phosphofructokinase activity
DO83_RS07930	COG1063	alcohol dehydrogenase
DO83_RS07940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DO83_RS07955	COG0515	serine threonine protein kinase
DO83_RS07975	COG0469	pyruvate kinase activity
DO83_RS07980	COG0366	Alpha amylase catalytic
DO83_RS07995	COG2226	methyltransferase
DO83_RS08030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DO83_RS08035	COG0534	Mate efflux family protein
DO83_RS08070	COG0697	spore germination
DO83_RS08110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DO83_RS08115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DO83_RS08120	COG1687	branched-chain amino acid
DO83_RS08125	COG0626	cystathionine gamma-synthase activity
DO83_RS08135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DO83_RS08140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DO83_RS08155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS08160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS08160	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DO83_RS08160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS08165	COG0191	fructose-bisphosphate aldolase activity
DO83_RS08170	COG0191	fructose-bisphosphate aldolase activity
DO83_RS08175	COG1940	carbohydrate kinase activity
DO83_RS08180	COG1737	Transcriptional regulator
DO83_RS08190	COG1486	melibiose metabolic process
DO83_RS08195	COG1486	melibiose metabolic process
DO83_RS08205	COG1263	PTS System
DO83_RS08205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS08205	COG2190	(PTS) system
DO83_RS08220	COG0745	RESPONSE REGULATOR receiver
DO83_RS08225	COG5002	protein histidine kinase activity
DO83_RS08255	COG2252	PERMEase
DO83_RS08260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DO83_RS08285	COG0534	Mate efflux family protein
DO83_RS08295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DO83_RS08310	COG0583	DNA-binding transcription factor activity
DO83_RS08320	COG1459	type II secretion system
DO83_RS08360	COG2080	2 iron, 2 sulfur cluster binding
DO83_RS08365	COG2080	2 iron, 2 sulfur cluster binding
DO83_RS08365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DO83_RS08375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DO83_RS08380	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DO83_RS08385	COG0193	aminoacyl-tRNA hydrolase activity
DO83_RS08390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DO83_RS08400	COG1349	DNA-binding transcription factor activity
DO83_RS08405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DO83_RS08410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS08425	COG3775	system Galactitol-specific IIC component
DO83_RS08430	COG0371	Dehydrogenase
DO83_RS08445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DO83_RS08460	COG2188	Transcriptional regulator
DO83_RS08480	COG0246	Mannitol dehydrogenase
DO83_RS08485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS08485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS08485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS08520	COG4989	oxidoreductase activity
DO83_RS08525	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
DO83_RS08535	COG3547	Transposase (IS116 IS110 IS902 family)
DO83_RS08540	COG1301	dicarboxylic acid transport
DO83_RS08555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DO83_RS08560	COG0569	domain protein
DO83_RS08565	COG2205	protein histidine kinase activity
DO83_RS08570	COG0745	RESPONSE REGULATOR receiver
DO83_RS08575	COG1760	l-serine dehydratase
DO83_RS08585	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DO83_RS08590	COG0583	DNA-binding transcription factor activity
DO83_RS08615	COG0484	heat shock protein binding
DO83_RS08625	COG1454	alcohol dehydrogenase
DO83_RS08630	COG3711	transcriptional antiterminator
DO83_RS08630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS08635	COG1735	metal-dependent hydrolase with the TIM-barrel fold
DO83_RS08650	COG3775	system Galactitol-specific IIC component
DO83_RS08655	COG4948	Mandelate Racemase Muconate Lactonizing
DO83_RS08660	COG0800	Aldolase
DO83_RS08665	COG0534	Mate efflux family protein
DO83_RS08670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DO83_RS08675	COG0617	tRNA 3'-terminal CCA addition
DO83_RS08680	COG0584	glycerophosphoryl diester phosphodiesterase
DO83_RS08685	COG1181	Belongs to the D-alanine--D-alanine ligase family
DO83_RS08690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DO83_RS08700	COG2205	protein histidine kinase activity
DO83_RS08705	COG0745	RESPONSE REGULATOR receiver
DO83_RS08710	COG0004	ammonium transporteR
DO83_RS08715	COG0004	ammonium transporteR
DO83_RS08720	COG0347	Belongs to the P(II) protein family
DO83_RS08740	COG1072	(Pantothenic acid kinase))
DO83_RS08765	COG1760	l-serine dehydratase
DO83_RS08770	COG1760	l-serine dehydratase
DO83_RS08775	COG3142	Participates in the control of copper homeostasis
DO83_RS08785	COG0385	Bile acid
DO83_RS08800	COG4485	Bacterial membrane protein, YfhO
DO83_RS08805	COG1511	domain protein
DO83_RS08830	COG3279	Response regulator of the LytR AlgR family
DO83_RS08855	COG0561	phosphatase activity
DO83_RS08860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DO83_RS08865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DO83_RS08875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DO83_RS08885	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS08890	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DO83_RS08890	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DO83_RS08895	COG0191	fructose-bisphosphate aldolase activity
DO83_RS08915	COG3715	PTS system
DO83_RS08920	COG3716	PTS system mannose fructose sorbose family IID component
DO83_RS08925	COG0246	Mannitol dehydrogenase
DO83_RS08930	COG0667	Aldo Keto reductase
DO83_RS08935	COG2801	Transposase and inactivated derivatives
DO83_RS08960	COG1725	Transcriptional regulator
DO83_RS08965	COG1131	(ABC) transporter
DO83_RS08985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DO83_RS09015	COG1070	Carbohydrate kinase
DO83_RS09025	COG1773	rubredoxin
DO83_RS09035	COG1592	Rubrerythrin
DO83_RS09045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DO83_RS09055	COG0157	Belongs to the NadC ModD family
DO83_RS09110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DO83_RS09115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DO83_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
DO83_RS09125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DO83_RS09130	COG0511	ligase activity, forming carbon-carbon bonds
DO83_RS09135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DO83_RS09140	COG0439	Biotin carboxylase
DO83_RS09150	COG0825	malonyl-CoA metabolic process
DO83_RS09165	COG0051	transcription antitermination factor activity, RNA binding
DO83_RS09170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DO83_RS09185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DO83_RS09195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DO83_RS09205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DO83_RS09210	COG0255	Belongs to the universal ribosomal protein uL29 family
DO83_RS09215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DO83_RS09220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DO83_RS09225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DO83_RS09235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DO83_RS09240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DO83_RS09245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DO83_RS09250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DO83_RS09260	COG1841	ribosomal large subunit assembly
DO83_RS09270	COG0201	protein transport
DO83_RS09285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DO83_RS09290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DO83_RS09300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DO83_RS09305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DO83_RS09310	COG0202	RNA polymerase activity
DO83_RS09315	COG0203	ribosomal protein L17
DO83_RS09320	COG1122	ATPase activity
DO83_RS09325	COG1122	ATPase activity
DO83_RS09330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DO83_RS09335	COG0101	tRNA pseudouridine synthase activity
DO83_RS09345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DO83_RS09360	COG0148	phosphopyruvate hydratase activity
DO83_RS09375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DO83_RS09385	COG0426	domain, Protein
DO83_RS09395	COG0731	radical SAM domain protein
DO83_RS09415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DO83_RS09420	COG0492	ferredoxin-NADP+ reductase activity
DO83_RS09425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DO83_RS09430	COG0653	protein targeting
DO83_RS09435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DO83_RS09440	COG4492	Belongs to the UPF0735 family
DO83_RS09445	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DO83_RS09460	COG2183	response to ionizing radiation
DO83_RS09465	COG0300	oxidoreductase activity
DO83_RS09475	COG3835	regulator
DO83_RS09480	COG2884	Cell division ATP-binding protein ftsE
DO83_RS09485	COG2177	Part of the ABC transporter FtsEX involved in
DO83_RS09495	COG0793	Belongs to the peptidase S41A family
DO83_RS09500	COG1104	cysteine desulfurase activity
DO83_RS09590	COG0741	lytic transglycosylase activity
DO83_RS09590	COG0791	NLP P60 protein
DO83_RS09640	COG2946	Replication initiation factor
DO83_RS09650	COG1674	ftsk spoiiie
DO83_RS09705	COG1349	DNA-binding transcription factor activity
DO83_RS09710	COG1882	Formate acetyltransferase
DO83_RS09715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DO83_RS09720	COG2002	toxin-antitoxin pair type II binding
DO83_RS09730	COG0802	atpase or kinase
DO83_RS09735	COG1214	PFAM Peptidase M22, glycoprotease
DO83_RS09740	COG0456	acetyltransferase
DO83_RS09745	COG1234	tRNA 3'-trailer cleavage
DO83_RS09755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DO83_RS09850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS09850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS09850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS09855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS09860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS09860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS09860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS09870	COG0546	phosphoglycolate phosphatase activity
DO83_RS09880	COG0698	ribose 5-phosphate isomerase
DO83_RS09890	COG2376	Dihydroxyacetone kinase
DO83_RS09905	COG1131	(ABC) transporter
DO83_RS09925	COG0504	CTP synthase activity
DO83_RS09940	COG1063	alcohol dehydrogenase
DO83_RS09950	COG2217	Heavy metal translocating P-type atpase
DO83_RS09955	COG0640	Transcriptional regulator
DO83_RS09960	COG0460	homoserine dehydrogenase
DO83_RS09975	COG1309	transcriptional regulator
DO83_RS10010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DO83_RS10010	COG0512	Glutamine amidotransferase of anthranilate synthase
DO83_RS10025	COG0133	tryptophan synthase activity
DO83_RS10030	COG0159	tryptophan synthase activity
DO83_RS10035	COG0436	Aminotransferase
DO83_RS10040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DO83_RS10050	COG0628	permease
DO83_RS10100	COG3409	Peptidoglycan-binding domain 1 protein
DO83_RS10100	COG5632	N-Acetylmuramoyl-L-alanine amidase
DO83_RS10105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DO83_RS10110	COG1396	sequence-specific DNA binding
DO83_RS10115	COG2176	DNA-directed DNA polymerase activity
DO83_RS10260	COG0740	serine-type endopeptidase activity
DO83_RS10320	COG0791	NLP P60 protein
DO83_RS10335	COG3299	homolog of phage Mu protein gp47
DO83_RS10350	COG4974	Belongs to the 'phage' integrase family
DO83_RS10400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DO83_RS10405	COG0288	reversible hydration of carbon dioxide
DO83_RS10450	COG1418	mRNA catabolic process
DO83_RS10455	COG0494	nUDIX hydrolase
DO83_RS10465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DO83_RS10470	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DO83_RS10480	COG0406	alpha-ribazole phosphatase activity
DO83_RS10490	COG1473	amidohydrolase
DO83_RS10525	COG0539	negative regulation of cytoplasmic translation
DO83_RS10530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DO83_RS10535	COG0343	queuine tRNA-ribosyltransferase activity
DO83_RS10545	COG0613	PHP domain protein
DO83_RS10560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DO83_RS10565	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DO83_RS10565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DO83_RS10570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DO83_RS10570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DO83_RS10575	COG0561	phosphatase activity
DO83_RS10620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DO83_RS10630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DO83_RS10635	COG1187	pseudouridine synthase activity
DO83_RS10640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DO83_RS10645	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DO83_RS10650	COG0561	phosphatase activity
DO83_RS10655	COG0285	dihydrofolate synthase activity
DO83_RS10670	COG2172	sigma factor antagonist activity
DO83_RS10680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DO83_RS10685	COG0254	rRNA binding
DO83_RS10690	COG3872	metal-dependent enzyme
DO83_RS10695	COG2890	protein-(glutamine-N5) methyltransferase activity
DO83_RS10700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DO83_RS10715	COG4585	Histidine kinase
DO83_RS10720	COG2197	response regulator
DO83_RS10745	COG3716	PTS system mannose fructose sorbose family IID component
DO83_RS10755	COG3583	domain protein
DO83_RS10755	COG5492	domain, Protein
DO83_RS10755	COG1621	beta-fructofuranosidase activity
DO83_RS10760	COG0561	phosphatase activity
DO83_RS10795	COG2205	protein histidine kinase activity
DO83_RS10800	COG1472	Belongs to the glycosyl hydrolase 3 family
DO83_RS10805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DO83_RS10810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DO83_RS10830	COG3706	GGDEF domain
DO83_RS10845	COG1242	4 iron, 4 sulfur cluster binding
DO83_RS10855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DO83_RS10895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DO83_RS10905	COG3279	Response regulator of the LytR AlgR family
DO83_RS10910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DO83_RS10915	COG0402	S-adenosylhomocysteine deaminase activity
DO83_RS10940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DO83_RS10960	COG1191	sigma factor activity
DO83_RS10975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DO83_RS10980	COG1381	Involved in DNA repair and RecF pathway recombination
DO83_RS10990	COG0423	glycine-tRNA ligase activity
DO83_RS10995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DO83_RS11005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DO83_RS11025	COG0573	inorganic phosphate transmembrane transporter activity
DO83_RS11030	COG0581	inorganic phosphate transmembrane transporter activity
DO83_RS11035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DO83_RS11040	COG0704	Plays a role in the regulation of phosphate uptake
DO83_RS11045	COG0745	RESPONSE REGULATOR receiver
DO83_RS11050	COG5002	protein histidine kinase activity
DO83_RS11055	COG4193	domain, Protein
DO83_RS11060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DO83_RS11065	COG0765	amino acid transport
DO83_RS11070	COG1126	abc transporter atp-binding protein
DO83_RS11075	COG0372	Belongs to the citrate synthase family
DO83_RS11085	COG1408	metallophosphoesterase
DO83_RS11125	COG3037	sugar-specific permease SgaT UlaA
DO83_RS11140	COG0561	phosphatase activity
DO83_RS11185	COG1914	H( )-stimulated, divalent metal cation uptake system
DO83_RS11190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DO83_RS11195	COG1984	allophanate hydrolase subunit 2
DO83_RS11200	COG0511	ligase activity, forming carbon-carbon bonds
DO83_RS11205	COG0439	Biotin carboxylase
DO83_RS11210	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DO83_RS11215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DO83_RS11225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DO83_RS11245	COG0656	L-ascorbic acid biosynthetic process
DO83_RS11265	COG0561	phosphatase activity
DO83_RS11270	COG1686	Belongs to the peptidase S11 family
DO83_RS11275	COG1597	lipid kinase activity
DO83_RS11300	COG0116	Belongs to the methyltransferase superfamily
DO83_RS11315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DO83_RS11320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DO83_RS11325	COG3901	Regulator of nitric oxide reductase transcription
DO83_RS11325	COG0348	domain, Protein
DO83_RS11335	COG1136	(ABC) transporter
DO83_RS11350	COG5002	protein histidine kinase activity
DO83_RS11375	COG2211	Major facilitator Superfamily
DO83_RS11380	COG3250	beta-galactosidase activity
DO83_RS11395	COG0640	Transcriptional regulator
DO83_RS11400	COG0701	Predicted permease
DO83_RS11410	COG0798	PFAM Bile acid sodium symporter
DO83_RS11445	COG2239	Acts as a magnesium transporter
DO83_RS11450	COG2199	diguanylate cyclase activity
DO83_RS11450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DO83_RS11460	COG0673	inositol 2-dehydrogenase activity
DO83_RS11470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DO83_RS11475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DO83_RS11480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DO83_RS11490	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DO83_RS11495	COG1404	Belongs to the peptidase S8 family
DO83_RS11505	COG1959	2 iron, 2 sulfur cluster binding
DO83_RS11515	COG0822	iron-sulfur transferase activity
DO83_RS11520	COG0482	sulfurtransferase activity
DO83_RS11530	COG0745	RESPONSE REGULATOR receiver
DO83_RS11540	COG5002	protein histidine kinase activity
DO83_RS11550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DO83_RS11555	COG0107	imidazoleglycerol-phosphate synthase activity
DO83_RS11565	COG1598	PFAM Uncharacterised protein family UPF0150
DO83_RS11590	COG0598	Magnesium transport protein CorA
DO83_RS11625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DO83_RS11640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DO83_RS11645	COG1254	Belongs to the acylphosphatase family
DO83_RS11655	COG0742	ribosomal rna small subunit methyltransferase
DO83_RS11660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DO83_RS11675	COG1323	Belongs to the UPF0348 family
DO83_RS11680	COG0280	phosphate acetyltransferase
DO83_RS11695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DO83_RS11700	COG0416	fatty acid biosynthetic process
DO83_RS11705	COG0571	ribonuclease III activity
DO83_RS11715	COG0552	protein localization to endoplasmic reticulum
DO83_RS11720	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DO83_RS11730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DO83_RS11735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DO83_RS11740	COG0297	glycogen (starch) synthase activity
DO83_RS11750	COG0366	Alpha amylase catalytic
DO83_RS11750	COG3103	Sh3 type 3 domain protein
DO83_RS11755	COG1283	sodium-dependent phosphate transmembrane transporter activity
DO83_RS11760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DO83_RS11765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DO83_RS11775	COG0295	cytidine deaminase activity
DO83_RS11780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DO83_RS11785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DO83_RS11790	COG2003	Belongs to the UPF0758 family
DO83_RS11795	COG1077	Cell shape determining protein MreB Mrl
DO83_RS11815	COG0850	regulation of cytokinetic process
DO83_RS11820	COG2894	cell division
DO83_RS11825	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DO83_RS11830	COG0772	Belongs to the SEDS family
DO83_RS11835	COG1803	Methylglyoxal synthase
DO83_RS11840	COG1686	Belongs to the peptidase S11 family
DO83_RS11845	COG1242	4 iron, 4 sulfur cluster binding
DO83_RS11855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DO83_RS11860	COG1799	cell septum assembly
DO83_RS11865	COG2302	S4 RNA-binding domain
DO83_RS11870	COG3599	regulation of cell shape
DO83_RS11875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DO83_RS11885	COG0564	pseudouridine synthase activity
DO83_RS11890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DO83_RS11895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DO83_RS11900	COG1185	polyribonucleotide nucleotidyltransferase activity
DO83_RS11915	COG0424	maF-like protein
DO83_RS11920	COG1307	EDD domain protein, DegV family
DO83_RS11935	COG1404	Belongs to the peptidase S8 family
DO83_RS11940	COG0058	SHG alpha-glucan phosphorylase activity
DO83_RS11950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DO83_RS11960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS11965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS11975	COG3716	PTS system mannose fructose sorbose family IID component
DO83_RS11985	COG1737	Transcriptional regulator
DO83_RS12000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DO83_RS12005	COG3711	transcriptional antiterminator
DO83_RS12010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS12035	COG3209	COG3209 Rhs family protein
DO83_RS12050	COG3209	COG3209 Rhs family protein
DO83_RS12065	COG3209	COG3209 Rhs family protein
DO83_RS12090	COG3209	COG3209 Rhs family protein
DO83_RS12135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DO83_RS12140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DO83_RS12145	COG0210	DNA helicase
DO83_RS12160	COG0475	glutathione-regulated potassium exporter activity
DO83_RS12175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DO83_RS12185	COG1253	flavin adenine dinucleotide binding
DO83_RS12190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DO83_RS12195	COG1971	Probably functions as a manganese efflux pump
DO83_RS12200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DO83_RS12200	COG1328	CTP reductase activity
DO83_RS12210	COG2186	Transcriptional regulator
DO83_RS12215	COG0542	response to heat
DO83_RS12225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DO83_RS12230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DO83_RS12240	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS12245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DO83_RS12250	COG0459	protein refolding
DO83_RS12260	COG1063	alcohol dehydrogenase
DO83_RS12265	COG1979	alcohol dehydrogenase
DO83_RS12275	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DO83_RS12275	COG0493	'glutamate synthase
DO83_RS12285	COG0516	GMP reductase activity
DO83_RS12285	COG0517	IMP dehydrogenase activity
DO83_RS12290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DO83_RS12305	COG1183	phosphatidylcholine synthase activity
DO83_RS12310	COG0688	phosphatidylethanolamine metabolic process
DO83_RS12315	COG1115	amino acid carrier protein
DO83_RS12320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DO83_RS12330	COG3711	transcriptional antiterminator
DO83_RS12335	COG1263	PTS System
DO83_RS12335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DO83_RS12335	COG2190	(PTS) system
DO83_RS12340	COG2723	6-phospho-beta-galactosidase activity
DO83_RS12345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DO83_RS12345	COG0574	Belongs to the PEP-utilizing enzyme family
DO83_RS12350	COG1011	Hydrolase
DO83_RS12380	COG0039	L-malate dehydrogenase activity
DO83_RS12390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DO83_RS12395	COG0561	phosphatase activity
DO83_RS12410	COG0784	Response regulator, receiver
DO83_RS12410	COG2205	protein histidine kinase activity
DO83_RS12415	COG0039	L-malate dehydrogenase activity
DO83_RS12425	COG0534	Mate efflux family protein
DO83_RS12435	COG1309	transcriptional regulator
DO83_RS12455	COG1309	transcriptional regulator
DO83_RS12485	COG0583	DNA-binding transcription factor activity
DO83_RS12500	COG0656	L-ascorbic acid biosynthetic process
DO83_RS12520	COG3328	transposase activity
DO83_RS12525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DO83_RS12530	COG1757	Na H antiporter
DO83_RS12535	COG0572	uridine kinase
DO83_RS12565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DO83_RS12575	COG0632	four-way junction helicase activity
DO83_RS12580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS12580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS12580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DO83_RS12585	COG1609	Transcriptional regulator
DO83_RS12590	COG2160	L-arabinose isomerase activity
DO83_RS12610	COG2207	Transcriptional regulator
DO83_RS12610	COG4753	response regulator
DO83_RS12615	COG2972	Histidine kinase
DO83_RS12620	COG1879	ABC-type sugar transport system periplasmic component
DO83_RS12630	COG1172	Belongs to the binding-protein-dependent transport system permease family
DO83_RS12635	COG1172	Belongs to the binding-protein-dependent transport system permease family
DO83_RS12645	COG2207	Transcriptional regulator
DO83_RS12645	COG1609	Transcriptional regulator
DO83_RS12650	COG2211	Major facilitator Superfamily
DO83_RS12665	COG2190	(PTS) system
DO83_RS12675	COG1609	Transcriptional regulator
DO83_RS12680	COG2211	Major facilitator Superfamily
DO83_RS12685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DO83_RS12695	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DO83_RS12700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DO83_RS12710	COG1132	(ABC) transporter
DO83_RS12720	COG2059	Chromate
DO83_RS12725	COG0514	ATP-dependent DNA helicase (RecQ)
DO83_RS12735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DO83_RS12745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DO83_RS12750	COG0367	asparagine synthase
DO83_RS12765	COG0326	Molecular chaperone. Has ATPase activity
DO83_RS12770	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DO83_RS12780	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DO83_RS12795	COG0436	Aminotransferase
DO83_RS12805	COG0138	bifunctional purine biosynthesis protein purh
DO83_RS12815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DO83_RS12850	COG0012	GTP binding
DO83_RS12855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DO83_RS12860	COG2001	Belongs to the MraZ family
DO83_RS12865	COG0275	rRNA processing
DO83_RS12875	COG0768	penicillin binding
DO83_RS12880	COG0768	penicillin binding
DO83_RS12890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DO83_RS12895	COG0772	Belongs to the SEDS family
DO83_RS12905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DO83_RS12910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DO83_RS12915	COG1217	gtp-binding protein TYPA
DO83_RS12925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DO83_RS12930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DO83_RS12935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DO83_RS12975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DO83_RS12995	COG0318	PFAM AMP-dependent synthetase and ligase
DO83_RS13060	COG0582	viral genome integration into host DNA
DO83_RS13070	COG0544	peptidyl-prolyl cis-trans isomerase activity
DO83_RS13080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DO83_RS13085	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DO83_RS13090	COG0285	dihydrofolate synthase activity
DO83_RS13095	COG1418	mRNA catabolic process
DO83_RS13100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DO83_RS13105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DO83_RS13105	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DO83_RS13110	COG0077	Prephenate dehydratase
DO83_RS13110	COG1605	Chorismate mutase
DO83_RS13115	COG1368	sulfuric ester hydrolase activity
DO83_RS13125	COG0681	Belongs to the peptidase S26 family
DO83_RS13130	COG0251	oxidation-reduction process
DO83_RS13135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DO83_RS13165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DO83_RS13175	COG0632	four-way junction helicase activity
DO83_RS13180	COG2255	four-way junction helicase activity
DO83_RS13185	COG0826	peptidase U32
DO83_RS13195	COG0768	penicillin binding
DO83_RS13205	COG1686	Belongs to the peptidase S11 family
DO83_RS13215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS13215	COG3711	transcriptional antiterminator
DO83_RS13225	COG3730	PTS system glucitol sorbitol-specific
DO83_RS13230	COG3732	PTS system glucitol sorbitol-specific
DO83_RS13250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DO83_RS13255	COG0028	Belongs to the TPP enzyme family
DO83_RS13260	COG0440	acetolactate synthase activity
DO83_RS13265	COG0183	Belongs to the thiolase family
DO83_RS13270	COG1024	Enoyl-CoA hydratase
DO83_RS13275	COG1250	3-hydroxyacyl-CoA dehydrogenase
DO83_RS13280	COG1960	acyl-CoA dehydrogenase activity
DO83_RS13285	COG2086	electron transfer activity
DO83_RS13300	COG0427	acetyl-CoA hydrolase
DO83_RS13315	COG1686	Belongs to the peptidase S11 family
DO83_RS13320	COG1393	Belongs to the ArsC family
DO83_RS13325	COG1362	aminopeptidase activity
DO83_RS13335	COG1376	ErfK ybiS ycfS ynhG family protein
DO83_RS13350	COG0039	L-malate dehydrogenase activity
DO83_RS13370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DO83_RS13375	COG0352	thiamine-phosphate diphosphorylase activity
DO83_RS13385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DO83_RS13390	COG1757	Na H antiporter
DO83_RS13395	COG0714	Associated with various cellular activities
DO83_RS13410	COG0791	NLP P60 protein
DO83_RS13415	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DO83_RS13420	COG1530	ribonuclease E activity
DO83_RS13435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DO83_RS13440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DO83_RS13445	COG1534	Rna-binding protein
DO83_RS13450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DO83_RS13455	COG1713	HD superfamily hydrolase involved in NAD metabolism
DO83_RS13460	COG0799	negative regulation of ribosome biogenesis
DO83_RS13465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DO83_RS13470	COG1388	LysM domain
DO83_RS13475	COG0860	N-Acetylmuramoyl-L-alanine amidase
DO83_RS13480	COG0860	N-Acetylmuramoyl-L-alanine amidase
DO83_RS13500	COG0129	dihydroxy-acid dehydratase activity
DO83_RS13505	COG0028	Belongs to the TPP enzyme family
DO83_RS13510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DO83_RS13515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DO83_RS13525	COG0668	transmembrane transport
DO83_RS13540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DO83_RS13555	COG3209	COG3209 Rhs family protein
DO83_RS13610	COG2264	protein methyltransferase activity
DO83_RS13615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DO83_RS13620	COG1104	cysteine desulfurase activity
DO83_RS13635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DO83_RS13640	COG4472	Bacterial protein of unknown function (DUF965)
DO83_RS13655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DO83_RS13665	COG4122	O-methyltransferase activity
DO83_RS13670	COG0826	peptidase U32
DO83_RS13765	COG0745	RESPONSE REGULATOR receiver
DO83_RS13770	COG5002	protein histidine kinase activity
DO83_RS13785	COG0583	DNA-binding transcription factor activity
DO83_RS13805	COG0583	DNA-binding transcription factor activity
DO83_RS13815	COG2271	Major facilitator Superfamily
DO83_RS13830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DO83_RS13830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DO83_RS13835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DO83_RS13840	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DO83_RS13850	COG0583	DNA-binding transcription factor activity
DO83_RS13860	COG1979	alcohol dehydrogenase
DO83_RS13865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DO83_RS13875	COG0708	Exodeoxyribonuclease III
DO83_RS13880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DO83_RS13890	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DO83_RS13895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DO83_RS13900	COG4208	sulfate ABC transporter
DO83_RS13905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DO83_RS13915	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
DO83_RS13920	COG0175	sulfate reduction
DO83_RS13925	COG2895	sulfate adenylyltransferase (ATP) activity
DO83_RS13935	COG2213	PTS system mannitol-specific
DO83_RS13935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DO83_RS13940	COG0246	Mannitol dehydrogenase
DO83_RS13945	COG1882	Formate acetyltransferase
DO83_RS13950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DO83_RS13955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DO83_RS13960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DO83_RS13965	COG4521	taurine ABC transporter
DO83_RS13970	COG1116	anion transmembrane transporter activity
DO83_RS13975	COG1454	alcohol dehydrogenase
DO83_RS13990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DO83_RS13990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DO83_RS13995	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DO83_RS14005	COG0124	histidyl-tRNA synthetase
DO83_RS14010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DO83_RS14015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DO83_RS14020	COG0131	Imidazoleglycerol-phosphate dehydratase
DO83_RS14030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DO83_RS14035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DO83_RS14050	COG1702	phosphate starvation-inducible protein PhoH
DO83_RS14060	COG2244	polysaccharide biosynthetic process
DO83_RS14070	COG2081	HI0933 family
DO83_RS14075	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DO83_RS14080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DO83_RS14090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DO83_RS14095	COG4656	Part of a membrane complex involved in electron transport
DO83_RS14100	COG4658	electron transport chain
DO83_RS14105	COG4659	FMN binding
DO83_RS14110	COG4660	Part of a membrane complex involved in electron transport
DO83_RS14115	COG4657	Part of a membrane complex involved in electron transport
DO83_RS14120	COG2878	Part of a membrane complex involved in electron transport
DO83_RS14125	COG1873	PFAM PRC-barrel domain
DO83_RS14130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DO83_RS14135	COG0606	chelatase, subunit chli
DO83_RS14140	COG0758	DNA mediated transformation
DO83_RS14145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DO83_RS14150	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DO83_RS14155	COG0052	Belongs to the universal ribosomal protein uS2 family
DO83_RS14160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DO83_RS14165	COG1192	Involved in chromosome partitioning
DO83_RS14170	COG1475	DNA binding
DO83_RS14270	COG4509	Sortase family
DO83_RS14415	COG0582	viral genome integration into host DNA
DO83_RS14435	COG0494	nUDIX hydrolase
DO83_RS14545	COG0655	NAD(P)H dehydrogenase (quinone) activity
DO83_RS14585	COG4115	mRNA cleavage
DO83_RS14610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DO83_RS14620	COG1454	alcohol dehydrogenase
DO83_RS14635	COG2086	electron transfer activity
DO83_RS14640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DO83_RS14655	COG0351	phosphomethylpyrimidine kinase
DO83_RS14655	COG0352	thiamine-phosphate diphosphorylase activity
DO83_RS14675	COG1648	precorrin-2 dehydrogenase activity
DO83_RS14675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DO83_RS14680	COG0113	porphobilinogen synthase activity
DO83_RS14685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DO83_RS14690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DO83_RS14695	COG0181	hydroxymethylbilane synthase activity
DO83_RS14700	COG0671	phosphoesterase, PA-phosphatase related
DO83_RS14710	COG0534	Mate efflux family protein
DO83_RS14715	COG0709	Synthesizes selenophosphate from selenide and ATP
DO83_RS14730	COG0521	Mo-molybdopterin cofactor biosynthetic process
DO83_RS14735	COG4149	molybdate abc transporter
DO83_RS14755	COG3585	molybdate ion transport
DO83_RS14755	COG2005	Transcriptional regulator
DO83_RS14770	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DO83_RS14770	COG3608	succinylglutamate desuccinylase aspartoacylase
DO83_RS14775	COG3608	succinylglutamate desuccinylase aspartoacylase
DO83_RS14775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DO83_RS14780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DO83_RS14795	COG2188	Transcriptional regulator
DO83_RS14800	COG1131	(ABC) transporter
DO83_RS14815	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DO83_RS14825	COG3279	Response regulator of the LytR AlgR family
DO83_RS14830	COG3290	protein histidine kinase activity
DO83_RS14890	COG0791	NLP P60 protein
DO83_RS14890	COG0741	lytic transglycosylase activity
DO83_RS14920	COG2946	Replication initiation factor
DO83_RS14930	COG1674	ftsk spoiiie
DO83_RS14950	COG1131	(ABC) transporter
DO83_RS14965	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DO83_RS14975	COG1012	belongs to the aldehyde dehydrogenase family
DO83_RS14995	COG0622	Phosphoesterase
DO83_RS15010	COG1748	Saccharopine dehydrogenase
DO83_RS15015	COG2738	Putative neutral zinc metallopeptidase
DO83_RS15020	COG0328	RNA-DNA hybrid ribonuclease activity
DO83_RS15040	COG0824	Thioesterase
DO83_RS15045	COG0534	Mate efflux family protein
DO83_RS15070	COG0540	Belongs to the ATCase OTCase family
DO83_RS15080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DO83_RS15090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DO83_RS15100	COG0124	histidyl-tRNA synthetase
DO83_RS15110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DO83_RS15115	COG0527	aspartate kinase activity
DO83_RS15145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DO83_RS15145	COG0551	DNA topoisomerase type I activity
DO83_RS15150	COG3854	ATPases associated with a variety of cellular activities
DO83_RS15190	COG3328	transposase activity
DO83_RS15225	COG1518	maintenance of DNA repeat elements
DO83_RS15230	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DO83_RS15285	COG1401	restriction endodeoxyribonuclease activity
DO83_RS15310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DO83_RS15315	COG0697	spore germination
DO83_RS15340	COG0242	peptide deformylase activity
DO83_RS15400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DO83_RS15420	COG1024	Enoyl-CoA hydratase
DO83_RS15425	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DO83_RS15430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DO83_RS15440	COG1924	4 iron, 4 sulfur cluster binding
DO83_RS15445	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DO83_RS15460	COG3842	ATPase activity
DO83_RS15465	COG1176	ABC-type spermidine putrescine transport system, permease component I
DO83_RS15470	COG1177	transmembrane transport
DO83_RS15480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DO83_RS15490	COG0674	pyruvate-flavodoxin oxidoreductase activity
DO83_RS15495	COG1013	pyruvate-flavodoxin oxidoreductase activity
DO83_RS15500	COG0583	DNA-binding transcription factor activity
DO83_RS15505	COG1063	alcohol dehydrogenase
DO83_RS15510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DO83_RS15520	COG0583	DNA-binding transcription factor activity
DO83_RS15550	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DO83_RS15555	COG1247	-acetyltransferase
DO83_RS15560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DO83_RS15565	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DO83_RS15565	COG1918	ferrous iron import across plasma membrane
DO83_RS15575	COG1937	Protein conserved in bacteria
DO83_RS15590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DO83_RS15600	COG0519	Catalyzes the synthesis of GMP from XMP
DO83_RS15605	COG1408	metallophosphoesterase
DO83_RS15630	COG4974	Belongs to the 'phage' integrase family