locus-tag	class	description
AR1Y2_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AR1Y2_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AR1Y2_RS00025	COG0187	DNA topoisomerase II activity
AR1Y2_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AR1Y2_RS00055	COG1070	Carbohydrate kinase
AR1Y2_RS00110	COG0534	Mate efflux family protein
AR1Y2_RS00115	COG1748	Saccharopine dehydrogenase
AR1Y2_RS00130	COG3711	transcriptional antiterminator
AR1Y2_RS00150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS00155	COG3775	system Galactitol-specific IIC component
AR1Y2_RS00165	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS00170	COG1063	alcohol dehydrogenase
AR1Y2_RS00175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AR1Y2_RS00180	COG1063	alcohol dehydrogenase
AR1Y2_RS00185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AR1Y2_RS00190	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS00195	COG1105	Belongs to the carbohydrate kinase PfkB family
AR1Y2_RS00205	COG1609	Transcriptional regulator
AR1Y2_RS00235	COG0017	Asparaginyl-tRNA synthetase
AR1Y2_RS00250	COG1610	YqeY-like protein
AR1Y2_RS00260	COG0069	glutamate synthase activity
AR1Y2_RS00265	COG0084	hydrolase, TatD family'
AR1Y2_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AR1Y2_RS00280	COG0590	tRNA wobble adenosine to inosine editing
AR1Y2_RS00285	COG0598	Magnesium transport protein CorA
AR1Y2_RS00295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS00300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS00300	COG2213	PTS system mannitol-specific
AR1Y2_RS00310	COG3775	system Galactitol-specific IIC component
AR1Y2_RS00320	COG1063	alcohol dehydrogenase
AR1Y2_RS00325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AR1Y2_RS00330	COG1028	Short-chain dehydrogenase reductase Sdr
AR1Y2_RS00335	COG2357	RelA SpoT domain protein
AR1Y2_RS00365	COG4717	serine-type aminopeptidase activity
AR1Y2_RS00370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AR1Y2_RS00375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AR1Y2_RS00380	COG1484	DNA-dependent DNA replication
AR1Y2_RS00390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AR1Y2_RS00400	COG2088	sporulation resulting in formation of a cellular spore
AR1Y2_RS00505	COG1982	Orn Lys Arg decarboxylase major
AR1Y2_RS00510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AR1Y2_RS00515	COG0470	DNA polymerase III
AR1Y2_RS00520	COG1774	PSP1 C-terminal conserved region
AR1Y2_RS00525	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AR1Y2_RS00530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AR1Y2_RS00535	COG2002	toxin-antitoxin pair type II binding
AR1Y2_RS00560	COG1846	Transcriptional regulator
AR1Y2_RS00590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS00600	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS00605	COG1063	alcohol dehydrogenase
AR1Y2_RS00620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AR1Y2_RS00625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AR1Y2_RS00630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AR1Y2_RS00635	COG1120	ATPase activity
AR1Y2_RS00670	COG3732	PTS system glucitol sorbitol-specific
AR1Y2_RS00675	COG3730	PTS system glucitol sorbitol-specific
AR1Y2_RS00685	COG1063	alcohol dehydrogenase
AR1Y2_RS00695	COG2390	Transcriptional regulator
AR1Y2_RS00725	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AR1Y2_RS00730	COG0583	DNA-binding transcription factor activity
AR1Y2_RS00735	COG0657	acetylesterase activity
AR1Y2_RS00740	COG2190	(PTS) system
AR1Y2_RS00740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS00740	COG1263	PTS System
AR1Y2_RS00745	COG3711	transcriptional antiterminator
AR1Y2_RS00750	COG1193	negative regulation of DNA recombination
AR1Y2_RS00755	COG3481	metal-dependent phosphohydrolase, HD sub domain
AR1Y2_RS00760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AR1Y2_RS00800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AR1Y2_RS00800	COG2205	protein histidine kinase activity
AR1Y2_RS00810	COG3706	GGDEF domain
AR1Y2_RS00815	COG2226	methyltransferase
AR1Y2_RS00820	COG2153	protein acetylation
AR1Y2_RS00845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AR1Y2_RS00850	COG3706	GGDEF domain
AR1Y2_RS00905	COG1051	belongs to the nudix hydrolase family
AR1Y2_RS00910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AR1Y2_RS00915	COG0785	Cytochrome C biogenesis protein
AR1Y2_RS00920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AR1Y2_RS00940	COG1454	alcohol dehydrogenase
AR1Y2_RS00960	COG3022	response to hydroperoxide
AR1Y2_RS00975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AR1Y2_RS01005	COG0419	ATPase involved in DNA repair
AR1Y2_RS01050	COG3620	sequence-specific DNA binding
AR1Y2_RS01055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AR1Y2_RS01060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AR1Y2_RS01075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS01080	COG3715	PTS system
AR1Y2_RS01085	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS01090	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS01095	COG0363	glucosamine-6-phosphate deaminase activity
AR1Y2_RS01110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AR1Y2_RS01115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AR1Y2_RS01120	COG1116	anion transmembrane transporter activity
AR1Y2_RS01150	COG3775	system Galactitol-specific IIC component
AR1Y2_RS01155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AR1Y2_RS01165	COG1063	alcohol dehydrogenase
AR1Y2_RS01185	COG2207	Transcriptional regulator
AR1Y2_RS01185	COG3708	Transcriptional regulator
AR1Y2_RS01205	COG1063	alcohol dehydrogenase
AR1Y2_RS01210	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS01220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS01225	COG1028	Short-chain dehydrogenase reductase Sdr
AR1Y2_RS01230	COG2188	Transcriptional regulator
AR1Y2_RS01280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AR1Y2_RS01315	COG0514	ATP-dependent DNA helicase (RecQ)
AR1Y2_RS01320	COG0242	peptide deformylase activity
AR1Y2_RS01330	COG2186	Transcriptional regulator
AR1Y2_RS01340	COG1063	alcohol dehydrogenase
AR1Y2_RS01345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS01345	COG2213	PTS system mannitol-specific
AR1Y2_RS01355	COG3775	system Galactitol-specific IIC component
AR1Y2_RS01365	COG2376	Dihydroxyacetone kinase
AR1Y2_RS01370	COG1461	Dihydroxyacetone kinase
AR1Y2_RS01380	COG0129	dihydroxy-acid dehydratase activity
AR1Y2_RS01385	COG1063	alcohol dehydrogenase
AR1Y2_RS01390	COG0436	Aminotransferase
AR1Y2_RS01395	COG0531	amino acid
AR1Y2_RS01405	COG1028	Short-chain dehydrogenase reductase Sdr
AR1Y2_RS01410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AR1Y2_RS01415	COG0800	Aldolase
AR1Y2_RS01425	COG1132	(ABC) transporter
AR1Y2_RS01460	COG3300	MHYT domain
AR1Y2_RS01460	COG5001	Diguanylate cyclase
AR1Y2_RS01500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AR1Y2_RS01505	COG0193	aminoacyl-tRNA hydrolase activity
AR1Y2_RS01510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AR1Y2_RS01530	COG0629	single-stranded DNA binding
AR1Y2_RS01535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AR1Y2_RS01540	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AR1Y2_RS01545	COG0359	binds to the 23S rRNA
AR1Y2_RS01550	COG0305	Participates in initiation and elongation during chromosome replication
AR1Y2_RS01560	COG2768	binding domain, Protein
AR1Y2_RS01575	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS01580	COG3775	system Galactitol-specific IIC component
AR1Y2_RS01585	COG2376	Dihydroxyacetone kinase
AR1Y2_RS01600	COG2376	Dihydroxyacetone kinase
AR1Y2_RS01635	COG1979	alcohol dehydrogenase
AR1Y2_RS01645	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS01660	COG0860	N-Acetylmuramoyl-L-alanine amidase
AR1Y2_RS01665	COG1115	amino acid carrier protein
AR1Y2_RS01670	COG0009	L-threonylcarbamoyladenylate synthase
AR1Y2_RS01675	COG0698	ribose 5-phosphate isomerase
AR1Y2_RS01700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AR1Y2_RS01705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AR1Y2_RS01710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AR1Y2_RS01715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AR1Y2_RS01720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AR1Y2_RS01725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AR1Y2_RS01730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AR1Y2_RS01740	COG2954	triphosphatase activity
AR1Y2_RS01745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AR1Y2_RS01750	COG3118	belongs to the thioredoxin family
AR1Y2_RS01755	COG0488	(ABC) transporter
AR1Y2_RS01765	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS01775	COG2972	Histidine kinase
AR1Y2_RS01780	COG4753	response regulator
AR1Y2_RS01780	COG2207	Transcriptional regulator
AR1Y2_RS01785	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS01800	COG0628	permease
AR1Y2_RS01805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AR1Y2_RS01825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AR1Y2_RS01830	COG0432	Pfam Uncharacterised protein family UPF0047
AR1Y2_RS01840	COG4509	Sortase family
AR1Y2_RS01860	COG2996	Protein conserved in bacteria
AR1Y2_RS01865	COG3956	TIGRFAM MazG family protein
AR1Y2_RS01875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AR1Y2_RS01895	COG3711	transcriptional antiterminator
AR1Y2_RS01895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS01930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AR1Y2_RS02005	COG0446	pyridine nucleotide-disulphide oxidoreductase
AR1Y2_RS02030	COG0037	tRNA processing
AR1Y2_RS02040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AR1Y2_RS02045	COG1301	dicarboxylic acid transport
AR1Y2_RS02060	COG0534	Mate efflux family protein
AR1Y2_RS02075	COG1278	Cold shock
AR1Y2_RS02105	COG1484	DNA-dependent DNA replication
AR1Y2_RS02115	COG5484	DNA packaging
AR1Y2_RS02115	COG3728	DNA packaging
AR1Y2_RS02225	COG3620	sequence-specific DNA binding
AR1Y2_RS02310	COG0281	malic enzyme
AR1Y2_RS02320	COG0534	Mate efflux family protein
AR1Y2_RS02340	COG1640	4-alpha-glucanotransferase
AR1Y2_RS02345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AR1Y2_RS02350	COG2176	DNA-directed DNA polymerase activity
AR1Y2_RS02355	COG2720	vancomycin resistance protein
AR1Y2_RS02365	COG1522	sequence-specific DNA binding
AR1Y2_RS02370	COG0436	Aminotransferase
AR1Y2_RS02385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AR1Y2_RS02390	COG0617	tRNA 3'-terminal CCA addition
AR1Y2_RS02400	COG1181	Belongs to the D-alanine--D-alanine ligase family
AR1Y2_RS02405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AR1Y2_RS02415	COG0671	phosphoesterase, PA-phosphatase related
AR1Y2_RS02455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AR1Y2_RS02465	COG0646	methionine synthase
AR1Y2_RS02465	COG1410	methionine synthase
AR1Y2_RS02470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AR1Y2_RS02475	COG1687	branched-chain amino acid
AR1Y2_RS02485	COG3706	GGDEF domain
AR1Y2_RS02500	COG3711	transcriptional antiterminator
AR1Y2_RS02530	COG1063	alcohol dehydrogenase
AR1Y2_RS02535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AR1Y2_RS02540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AR1Y2_RS02545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS02550	COG1063	alcohol dehydrogenase
AR1Y2_RS02555	COG2390	Transcriptional regulator
AR1Y2_RS02575	COG2390	Transcriptional regulator
AR1Y2_RS02600	COG1063	alcohol dehydrogenase
AR1Y2_RS02615	COG1760	l-serine dehydratase
AR1Y2_RS02620	COG1760	l-serine dehydratase
AR1Y2_RS02630	COG1737	Transcriptional regulator
AR1Y2_RS02635	COG1105	Belongs to the carbohydrate kinase PfkB family
AR1Y2_RS02640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS02640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS02640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS02645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS02645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS02645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS02650	COG1349	DNA-binding transcription factor activity
AR1Y2_RS02655	COG1072	(Pantothenic acid kinase))
AR1Y2_RS02660	COG1063	alcohol dehydrogenase
AR1Y2_RS02665	COG0512	Glutamine amidotransferase of anthranilate synthase
AR1Y2_RS02665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AR1Y2_RS02670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AR1Y2_RS02685	COG1408	metallophosphoesterase
AR1Y2_RS02690	COG1733	regulation of RNA biosynthetic process
AR1Y2_RS02720	COG0583	DNA-binding transcription factor activity
AR1Y2_RS02740	COG1691	(AIR) carboxylase
AR1Y2_RS02750	COG1606	tRNA processing
AR1Y2_RS02755	COG0310	cobalt ion transport
AR1Y2_RS02765	COG1122	ATPase activity
AR1Y2_RS02770	COG0789	Transcriptional regulator
AR1Y2_RS02780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AR1Y2_RS02790	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AR1Y2_RS02790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AR1Y2_RS02815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS02820	COG3715	PTS system
AR1Y2_RS02825	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS02830	COG0191	fructose-bisphosphate aldolase activity
AR1Y2_RS02835	COG1979	alcohol dehydrogenase
AR1Y2_RS02840	COG1063	alcohol dehydrogenase
AR1Y2_RS02850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AR1Y2_RS02855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AR1Y2_RS02860	COG1024	Enoyl-CoA hydratase
AR1Y2_RS02880	COG0038	chloride channel
AR1Y2_RS02890	COG0561	phosphatase activity
AR1Y2_RS02900	COG1686	Belongs to the peptidase S11 family
AR1Y2_RS02905	COG1597	lipid kinase activity
AR1Y2_RS02925	COG4251	negative regulation of phosphorylation
AR1Y2_RS02925	COG2203	Gaf domain
AR1Y2_RS02925	COG3706	GGDEF domain
AR1Y2_RS02925	COG5001	Diguanylate cyclase
AR1Y2_RS02930	COG1882	Formate acetyltransferase
AR1Y2_RS02935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AR1Y2_RS02940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS02945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS02955	COG2390	Transcriptional regulator
AR1Y2_RS02960	COG0657	acetylesterase activity
AR1Y2_RS02965	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AR1Y2_RS02975	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AR1Y2_RS02975	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AR1Y2_RS02990	COG1063	alcohol dehydrogenase
AR1Y2_RS03000	COG3715	PTS system
AR1Y2_RS03010	COG0246	Mannitol dehydrogenase
AR1Y2_RS03015	COG0667	Aldo Keto reductase
AR1Y2_RS03030	COG1115	amino acid carrier protein
AR1Y2_RS03045	COG1131	(ABC) transporter
AR1Y2_RS03060	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS03065	COG2205	protein histidine kinase activity
AR1Y2_RS03070	COG0004	ammonium transporteR
AR1Y2_RS03080	COG0697	spore germination
AR1Y2_RS03090	COG1959	2 iron, 2 sulfur cluster binding
AR1Y2_RS03095	COG1511	domain protein
AR1Y2_RS03110	COG0116	Belongs to the methyltransferase superfamily
AR1Y2_RS03115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AR1Y2_RS03145	COG4335	DNA alkylation repair
AR1Y2_RS03150	COG0513	Belongs to the DEAD box helicase family
AR1Y2_RS03185	COG2252	PERMEase
AR1Y2_RS03190	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AR1Y2_RS03220	COG3711	transcriptional antiterminator
AR1Y2_RS03240	COG3959	Transketolase, thiamine diphosphate binding domain
AR1Y2_RS03245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AR1Y2_RS03250	COG1929	Belongs to the glycerate kinase type-1 family
AR1Y2_RS03255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AR1Y2_RS03290	COG1174	glycine betaine transport
AR1Y2_RS03295	COG1125	glycine betaine transport
AR1Y2_RS03295	COG0517	IMP dehydrogenase activity
AR1Y2_RS03300	COG3708	Transcriptional regulator
AR1Y2_RS03300	COG2207	Transcriptional regulator
AR1Y2_RS03305	COG2188	Transcriptional regulator
AR1Y2_RS03310	COG1263	PTS System
AR1Y2_RS03310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS03315	COG0366	Alpha amylase catalytic
AR1Y2_RS03345	COG3730	PTS system glucitol sorbitol-specific
AR1Y2_RS03350	COG3732	PTS system glucitol sorbitol-specific
AR1Y2_RS03355	COG3732	PTS system glucitol sorbitol-specific
AR1Y2_RS03365	COG2188	Transcriptional regulator
AR1Y2_RS03375	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AR1Y2_RS03395	COG1968	undecaprenyl-diphosphatase activity
AR1Y2_RS03435	COG0784	Response regulator, receiver
AR1Y2_RS03435	COG2205	protein histidine kinase activity
AR1Y2_RS03440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AR1Y2_RS03460	COG0561	phosphatase activity
AR1Y2_RS03475	COG3437	response regulator, receiver
AR1Y2_RS03480	COG2205	protein histidine kinase activity
AR1Y2_RS03480	COG0784	Response regulator, receiver
AR1Y2_RS03485	COG3885	ferrous iron binding
AR1Y2_RS03485	COG2078	PFAM AMMECR1 domain protein
AR1Y2_RS03490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AR1Y2_RS03510	COG0768	penicillin binding
AR1Y2_RS03530	COG0372	Belongs to the citrate synthase family
AR1Y2_RS03540	COG1846	Transcriptional regulator
AR1Y2_RS03545	COG3706	GGDEF domain
AR1Y2_RS03560	COG0460	homoserine dehydrogenase
AR1Y2_RS03565	COG0697	spore germination
AR1Y2_RS03585	COG2205	protein histidine kinase activity
AR1Y2_RS03590	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS03595	COG2205	protein histidine kinase activity
AR1Y2_RS03605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AR1Y2_RS03610	COG0640	Transcriptional regulator
AR1Y2_RS03625	COG0656	L-ascorbic acid biosynthetic process
AR1Y2_RS03650	COG1136	(ABC) transporter
AR1Y2_RS03660	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS03665	COG0642	Histidine kinase
AR1Y2_RS03675	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS03680	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS03685	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS03690	COG1063	alcohol dehydrogenase
AR1Y2_RS03695	COG2211	Major facilitator Superfamily
AR1Y2_RS03705	COG2207	Transcriptional regulator
AR1Y2_RS03705	COG3708	Transcriptional regulator
AR1Y2_RS03715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AR1Y2_RS03715	COG0723	plastoquinol--plastocyanin reductase activity
AR1Y2_RS03730	COG1331	Highly conserved protein containing a thioredoxin domain
AR1Y2_RS03745	COG2205	protein histidine kinase activity
AR1Y2_RS03750	COG1472	Belongs to the glycosyl hydrolase 3 family
AR1Y2_RS03755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AR1Y2_RS03760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AR1Y2_RS03765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AR1Y2_RS03770	COG1597	lipid kinase activity
AR1Y2_RS03775	COG1228	amidohydrolase
AR1Y2_RS03780	COG1609	Transcriptional regulator
AR1Y2_RS03790	COG3959	Transketolase, thiamine diphosphate binding domain
AR1Y2_RS03795	COG3958	Transketolase
AR1Y2_RS03800	COG3711	transcriptional antiterminator
AR1Y2_RS03800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS03805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS03810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS03815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS03815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS03820	COG0191	fructose-bisphosphate aldolase activity
AR1Y2_RS03835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AR1Y2_RS03850	COG1368	sulfuric ester hydrolase activity
AR1Y2_RS03855	COG0544	peptidyl-prolyl cis-trans isomerase activity
AR1Y2_RS03865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AR1Y2_RS03870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AR1Y2_RS03875	COG0285	dihydrofolate synthase activity
AR1Y2_RS03885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AR1Y2_RS03890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AR1Y2_RS03890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AR1Y2_RS03895	COG0077	Prephenate dehydratase
AR1Y2_RS03895	COG1605	Chorismate mutase
AR1Y2_RS03900	COG1368	sulfuric ester hydrolase activity
AR1Y2_RS03910	COG0681	Belongs to the peptidase S26 family
AR1Y2_RS03920	COG0251	oxidation-reduction process
AR1Y2_RS03925	COG3706	GGDEF domain
AR1Y2_RS03930	COG0534	Mate efflux family protein
AR1Y2_RS03935	COG0366	Alpha amylase catalytic
AR1Y2_RS03955	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AR1Y2_RS03955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AR1Y2_RS03965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AR1Y2_RS03985	COG1609	Transcriptional regulator
AR1Y2_RS03990	COG2211	Major facilitator Superfamily
AR1Y2_RS03995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AR1Y2_RS04005	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AR1Y2_RS04010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AR1Y2_RS04015	COG3279	Response regulator of the LytR AlgR family
AR1Y2_RS04025	COG2033	superoxide reductase activity
AR1Y2_RS04035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AR1Y2_RS04040	COG0367	asparagine synthase
AR1Y2_RS04080	COG4974	Belongs to the 'phage' integrase family
AR1Y2_RS04325	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AR1Y2_RS04330	COG1793	dna ligase
AR1Y2_RS04345	COG2378	regulation of single-species biofilm formation
AR1Y2_RS04355	COG1464	Belongs to the NlpA lipoprotein family
AR1Y2_RS04360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AR1Y2_RS04370	COG0277	FAD linked oxidase domain protein
AR1Y2_RS04380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AR1Y2_RS04410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AR1Y2_RS04420	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AR1Y2_RS04430	COG1773	rubredoxin
AR1Y2_RS04435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AR1Y2_RS04440	COG0288	reversible hydration of carbon dioxide
AR1Y2_RS04445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AR1Y2_RS04485	COG1418	mRNA catabolic process
AR1Y2_RS04495	COG2213	PTS system mannitol-specific
AR1Y2_RS04495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS04500	COG1349	DNA-binding transcription factor activity
AR1Y2_RS04520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AR1Y2_RS04535	COG0588	phosphoglycerate mutase activity
AR1Y2_RS04545	COG1473	amidohydrolase
AR1Y2_RS04565	COG1131	(ABC) transporter
AR1Y2_RS04570	COG1725	Transcriptional regulator
AR1Y2_RS04575	COG0631	protein serine/threonine phosphatase activity
AR1Y2_RS04580	COG0515	serine threonine protein kinase
AR1Y2_RS04580	COG2815	serine threonine protein kinase
AR1Y2_RS04590	COG0539	negative regulation of cytoplasmic translation
AR1Y2_RS04600	COG0343	queuine tRNA-ribosyltransferase activity
AR1Y2_RS04605	COG1862	Preprotein translocase
AR1Y2_RS04660	COG1475	DNA binding
AR1Y2_RS04665	COG4443	Transcriptional Coactivator p15 (PC4)
AR1Y2_RS04680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AR1Y2_RS04690	COG0613	PHP domain protein
AR1Y2_RS04705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AR1Y2_RS04705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AR1Y2_RS04710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AR1Y2_RS04710	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AR1Y2_RS04715	COG0561	phosphatase activity
AR1Y2_RS04720	COG0420	3'-5' exonuclease activity
AR1Y2_RS04725	COG0419	ATPase involved in DNA repair
AR1Y2_RS04745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AR1Y2_RS04765	COG1187	pseudouridine synthase activity
AR1Y2_RS04770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AR1Y2_RS04780	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AR1Y2_RS04795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AR1Y2_RS04820	COG1349	DNA-binding transcription factor activity
AR1Y2_RS04825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AR1Y2_RS04830	COG1882	Formate acetyltransferase
AR1Y2_RS04850	COG1063	alcohol dehydrogenase
AR1Y2_RS04860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS04860	COG3711	transcriptional antiterminator
AR1Y2_RS04865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS04870	COG0561	phosphatase activity
AR1Y2_RS04875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AR1Y2_RS04880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AR1Y2_RS04885	COG2333	competence protein COMEC
AR1Y2_RS04885	COG0658	competence protein
AR1Y2_RS04895	COG0347	Belongs to the P(II) protein family
AR1Y2_RS04900	COG3842	ATPase activity
AR1Y2_RS04910	COG1177	transmembrane transport
AR1Y2_RS04925	COG2267	carboxylic ester hydrolase activity
AR1Y2_RS04935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AR1Y2_RS04950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AR1Y2_RS04950	COG0574	Belongs to the PEP-utilizing enzyme family
AR1Y2_RS04960	COG0148	phosphopyruvate hydratase activity
AR1Y2_RS04985	COG1132	(ABC) transporter
AR1Y2_RS05010	COG1918	ferrous iron import across plasma membrane
AR1Y2_RS05010	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AR1Y2_RS05020	COG0583	DNA-binding transcription factor activity
AR1Y2_RS05055	COG0426	domain, Protein
AR1Y2_RS05060	COG1960	acyl-CoA dehydrogenase activity
AR1Y2_RS05075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AR1Y2_RS05075	COG2080	2 iron, 2 sulfur cluster binding
AR1Y2_RS05085	COG1396	sequence-specific DNA binding
AR1Y2_RS05090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AR1Y2_RS05095	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS05110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AR1Y2_RS05125	COG0385	Bile acid
AR1Y2_RS05150	COG1609	Transcriptional regulator
AR1Y2_RS05155	COG1263	PTS System
AR1Y2_RS05155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS05155	COG2190	(PTS) system
AR1Y2_RS05160	COG1621	beta-fructofuranosidase activity
AR1Y2_RS05165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AR1Y2_RS05175	COG1695	Transcriptional regulator
AR1Y2_RS05195	COG2388	GCN5-related N-acetyl-transferase
AR1Y2_RS05215	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS05220	COG4989	oxidoreductase activity
AR1Y2_RS05225	COG3775	system Galactitol-specific IIC component
AR1Y2_RS05230	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AR1Y2_RS05245	COG0371	Dehydrogenase
AR1Y2_RS05265	COG0432	Pfam Uncharacterised protein family UPF0047
AR1Y2_RS05270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AR1Y2_RS05285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AR1Y2_RS05285	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AR1Y2_RS05290	COG1960	acyl-CoA dehydrogenase activity
AR1Y2_RS05295	COG2086	electron transfer activity
AR1Y2_RS05300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AR1Y2_RS05320	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS05335	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS05340	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS05365	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AR1Y2_RS05380	COG0709	Synthesizes selenophosphate from selenide and ATP
AR1Y2_RS05390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AR1Y2_RS05395	COG1408	metallophosphoesterase
AR1Y2_RS05405	COG1115	amino acid carrier protein
AR1Y2_RS05435	COG3906	Belongs to the UPF0473 family
AR1Y2_RS05440	COG0475	glutathione-regulated potassium exporter activity
AR1Y2_RS05450	COG3608	succinylglutamate desuccinylase aspartoacylase
AR1Y2_RS05455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AR1Y2_RS05460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AR1Y2_RS05495	COG1349	DNA-binding transcription factor activity
AR1Y2_RS05500	COG1609	Transcriptional regulator
AR1Y2_RS05505	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS05510	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS05515	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS05525	COG0561	phosphatase activity
AR1Y2_RS05540	COG1773	rubredoxin
AR1Y2_RS05540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AR1Y2_RS05545	COG1609	Transcriptional regulator
AR1Y2_RS05555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AR1Y2_RS05560	COG3962	Belongs to the TPP enzyme family
AR1Y2_RS05590	COG1942	4-Oxalocrotonate Tautomerase
AR1Y2_RS05595	COG2086	electron transfer activity
AR1Y2_RS05600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AR1Y2_RS05605	COG2610	gluconate transmembrane transporter activity
AR1Y2_RS05615	COG1024	Enoyl-CoA hydratase
AR1Y2_RS05620	COG1960	acyl-CoA dehydrogenase activity
AR1Y2_RS05630	COG1362	aminopeptidase activity
AR1Y2_RS05640	COG1151	hydroxylamine reductase activity
AR1Y2_RS05645	COG3842	ATPase activity
AR1Y2_RS05680	COG0287	Prephenate dehydrogenase
AR1Y2_RS05690	COG1649	PFAM Uncharacterised BCR, COG1649
AR1Y2_RS05700	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS05705	COG3775	system Galactitol-specific IIC component
AR1Y2_RS05710	COG1063	alcohol dehydrogenase
AR1Y2_RS05725	COG1979	alcohol dehydrogenase
AR1Y2_RS05730	COG1063	alcohol dehydrogenase
AR1Y2_RS05735	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS05765	COG1528	Iron-storage protein
AR1Y2_RS05780	COG3546	catalase activity
AR1Y2_RS05795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AR1Y2_RS05800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AR1Y2_RS05805	COG0569	domain protein
AR1Y2_RS05810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AR1Y2_RS05820	COG0066	3-isopropylmalate dehydratase activity
AR1Y2_RS05825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AR1Y2_RS05830	COG0066	3-isopropylmalate dehydratase activity
AR1Y2_RS05835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AR1Y2_RS05840	COG2059	Chromate
AR1Y2_RS05850	COG0583	DNA-binding transcription factor activity
AR1Y2_RS05855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AR1Y2_RS05890	COG0860	N-Acetylmuramoyl-L-alanine amidase
AR1Y2_RS05895	COG2267	carboxylic ester hydrolase activity
AR1Y2_RS05925	COG2239	Acts as a magnesium transporter
AR1Y2_RS05935	COG0726	polysaccharide deacetylase
AR1Y2_RS05975	COG1063	alcohol dehydrogenase
AR1Y2_RS05985	COG2271	Major facilitator Superfamily
AR1Y2_RS05990	COG1063	alcohol dehydrogenase
AR1Y2_RS05995	COG0191	fructose-bisphosphate aldolase activity
AR1Y2_RS06000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AR1Y2_RS06005	COG0667	Aldo Keto reductase
AR1Y2_RS06010	COG1349	DNA-binding transcription factor activity
AR1Y2_RS06015	COG1301	dicarboxylic acid transport
AR1Y2_RS06025	COG3344	reverse transcriptase
AR1Y2_RS06035	COG1971	Probably functions as a manganese efflux pump
AR1Y2_RS06045	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AR1Y2_RS06080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AR1Y2_RS06100	COG1739	Uncharacterized protein family UPF0029
AR1Y2_RS06105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AR1Y2_RS06130	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AR1Y2_RS06135	COG1074	ATP-dependent DNA helicase activity
AR1Y2_RS06145	COG0402	S-adenosylhomocysteine deaminase activity
AR1Y2_RS06160	COG2022	thiamine diphosphate biosynthetic process
AR1Y2_RS06170	COG0352	thiamine-phosphate diphosphorylase activity
AR1Y2_RS06180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AR1Y2_RS06185	COG4106	trans-aconitate 2-methyltransferase activity
AR1Y2_RS06190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AR1Y2_RS06210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AR1Y2_RS06225	COG3708	Transcriptional regulator
AR1Y2_RS06225	COG2207	Transcriptional regulator
AR1Y2_RS06230	COG1191	sigma factor activity
AR1Y2_RS06235	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AR1Y2_RS06245	COG0583	DNA-binding transcription factor activity
AR1Y2_RS06250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AR1Y2_RS06255	COG0006	proline dipeptidase activity
AR1Y2_RS06260	COG0205	6-phosphofructokinase activity
AR1Y2_RS06265	COG1295	ribonuclease BN
AR1Y2_RS06270	COG3711	transcriptional antiterminator
AR1Y2_RS06280	COG3715	PTS system
AR1Y2_RS06285	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS06295	COG1482	cell wall glycoprotein biosynthetic process
AR1Y2_RS06300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS06300	COG2190	(PTS) system
AR1Y2_RS06300	COG1263	PTS System
AR1Y2_RS06305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AR1Y2_RS06310	COG0800	Aldolase
AR1Y2_RS06320	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS06325	COG3715	PTS system
AR1Y2_RS06330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS06335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS06335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS06345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AR1Y2_RS06370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AR1Y2_RS06375	COG0534	Mate efflux family protein
AR1Y2_RS06380	COG2081	HI0933 family
AR1Y2_RS06385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AR1Y2_RS06395	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AR1Y2_RS06400	COG0740	serine-type endopeptidase activity
AR1Y2_RS06425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AR1Y2_RS06435	COG1546	Belongs to the CinA family
AR1Y2_RS06435	COG1058	Belongs to the CinA family
AR1Y2_RS06440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AR1Y2_RS06460	COG0488	(ABC) transporter
AR1Y2_RS06470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AR1Y2_RS06475	COG0228	four-way junction DNA binding
AR1Y2_RS06480	COG1837	Belongs to the UPF0109 family
AR1Y2_RS06485	COG0708	Exodeoxyribonuclease III
AR1Y2_RS06500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AR1Y2_RS06525	COG1854	S-ribosylhomocysteine lyase activity
AR1Y2_RS06575	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS06585	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS06590	COG1063	alcohol dehydrogenase
AR1Y2_RS06600	COG2188	Transcriptional regulator
AR1Y2_RS06605	COG2188	Transcriptional regulator
AR1Y2_RS06610	COG1063	alcohol dehydrogenase
AR1Y2_RS06615	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS06635	COG3711	transcriptional antiterminator
AR1Y2_RS06640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS06640	COG2190	(PTS) system
AR1Y2_RS06640	COG1263	PTS System
AR1Y2_RS06645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS06645	COG1263	PTS System
AR1Y2_RS06650	COG0363	glucosamine-6-phosphate deaminase activity
AR1Y2_RS06655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AR1Y2_RS06660	COG0860	N-Acetylmuramoyl-L-alanine amidase
AR1Y2_RS06675	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AR1Y2_RS06695	COG0149	triose-phosphate isomerase activity
AR1Y2_RS06710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AR1Y2_RS06715	COG0148	phosphopyruvate hydratase activity
AR1Y2_RS06725	COG0557	exoribonuclease II activity
AR1Y2_RS06730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AR1Y2_RS06800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AR1Y2_RS06805	COG2205	protein histidine kinase activity
AR1Y2_RS06825	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS06835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AR1Y2_RS06840	COG0336	Belongs to the RNA methyltransferase TrmD family
AR1Y2_RS06845	COG0335	large ribosomal subunit rRNA binding
AR1Y2_RS06860	COG0681	Belongs to the peptidase S26 family
AR1Y2_RS06865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AR1Y2_RS06870	COG0792	nuclease activity
AR1Y2_RS06875	COG1496	oxidoreductase activity
AR1Y2_RS06885	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AR1Y2_RS06895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AR1Y2_RS06900	COG0534	Mate efflux family protein
AR1Y2_RS06910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AR1Y2_RS06920	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AR1Y2_RS06925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AR1Y2_RS06930	COG2357	RelA SpoT domain protein
AR1Y2_RS06935	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AR1Y2_RS06935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AR1Y2_RS06940	COG1187	pseudouridine synthase activity
AR1Y2_RS06945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AR1Y2_RS06950	COG0300	oxidoreductase activity
AR1Y2_RS06955	COG0564	pseudouridine synthase activity
AR1Y2_RS06960	COG3331	DNA recombination
AR1Y2_RS06965	COG1561	YicC-like family, N-terminal region
AR1Y2_RS06970	COG0194	GDP metabolic process
AR1Y2_RS06975	COG1758	RNA polymerase activity
AR1Y2_RS06980	COG1968	undecaprenyl-diphosphatase activity
AR1Y2_RS06985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AR1Y2_RS06990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AR1Y2_RS06995	COG0358	DNA primase activity
AR1Y2_RS07000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AR1Y2_RS07005	COG2384	SAM-dependent methyltransferase
AR1Y2_RS07030	COG3773	Cell wall hydrolase
AR1Y2_RS07030	COG3409	Peptidoglycan-binding domain 1 protein
AR1Y2_RS07045	COG3842	ATPase activity
AR1Y2_RS07055	COG0583	DNA-binding transcription factor activity
AR1Y2_RS07065	COG3620	sequence-specific DNA binding
AR1Y2_RS07075	COG0602	queuosine metabolic process
AR1Y2_RS07080	COG0302	gtp cyclohydrolase
AR1Y2_RS07095	COG0070	glutamate synthase
AR1Y2_RS07095	COG0069	glutamate synthase activity
AR1Y2_RS07095	COG0067	glutamate synthase
AR1Y2_RS07100	COG0493	'glutamate synthase
AR1Y2_RS07135	COG0628	permease
AR1Y2_RS07145	COG1349	DNA-binding transcription factor activity
AR1Y2_RS07160	COG1882	Formate acetyltransferase
AR1Y2_RS07165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AR1Y2_RS07170	COG3715	PTS system
AR1Y2_RS07180	COG0028	Belongs to the TPP enzyme family
AR1Y2_RS07190	COG1959	2 iron, 2 sulfur cluster binding
AR1Y2_RS07195	COG0534	Mate efflux family protein
AR1Y2_RS07205	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AR1Y2_RS07205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AR1Y2_RS07210	COG0237	dephospho-CoA kinase activity
AR1Y2_RS07215	COG0456	acetyltransferase
AR1Y2_RS07225	COG1595	DNA-templated transcription, initiation
AR1Y2_RS07230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AR1Y2_RS07245	COG2195	Cleaves the N-terminal amino acid of tripeptides
AR1Y2_RS07250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AR1Y2_RS07275	COG0484	heat shock protein binding
AR1Y2_RS07280	COG0443	Heat shock 70 kDa protein
AR1Y2_RS07310	COG1674	ftsk spoiiie
AR1Y2_RS07320	COG2946	Replication initiation factor
AR1Y2_RS07470	COG3655	Transcriptional regulator
AR1Y2_RS07510	COG1420	regulation of RNA biosynthetic process
AR1Y2_RS07515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AR1Y2_RS07520	COG0443	Heat shock 70 kDa protein
AR1Y2_RS07525	COG0484	heat shock protein binding
AR1Y2_RS07530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS07530	COG3711	transcriptional antiterminator
AR1Y2_RS07535	COG0561	phosphatase activity
AR1Y2_RS07555	COG2207	Transcriptional regulator
AR1Y2_RS07555	COG1917	Cupin 2, conserved barrel domain protein
AR1Y2_RS07560	COG3263	regulation of cellular component size
AR1Y2_RS07570	COG2264	protein methyltransferase activity
AR1Y2_RS07575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AR1Y2_RS07580	COG1104	cysteine desulfurase activity
AR1Y2_RS07595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AR1Y2_RS07600	COG4472	Bacterial protein of unknown function (DUF965)
AR1Y2_RS07605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AR1Y2_RS07615	COG0735	belongs to the Fur family
AR1Y2_RS07620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AR1Y2_RS07630	COG4122	O-methyltransferase activity
AR1Y2_RS07635	COG0826	peptidase U32
AR1Y2_RS07650	COG0583	DNA-binding transcription factor activity
AR1Y2_RS07665	COG1309	transcriptional regulator
AR1Y2_RS07680	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS07695	COG1876	peptidase activity
AR1Y2_RS07730	COG0346	lactoylglutathione lyase activity
AR1Y2_RS07735	COG1396	sequence-specific DNA binding
AR1Y2_RS07745	COG0583	DNA-binding transcription factor activity
AR1Y2_RS07755	COG2814	Major facilitator Superfamily
AR1Y2_RS07775	COG0710	3-dehydroquinate dehydratase activity
AR1Y2_RS07780	COG0738	Major facilitator superfamily
AR1Y2_RS07790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AR1Y2_RS07790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AR1Y2_RS07795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AR1Y2_RS07805	COG1917	Cupin 2, conserved barrel domain protein
AR1Y2_RS07805	COG2207	Transcriptional regulator
AR1Y2_RS07810	COG2271	Major facilitator Superfamily
AR1Y2_RS07815	COG4670	ketone body catabolic process
AR1Y2_RS07820	COG2030	dehydratase
AR1Y2_RS07835	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AR1Y2_RS07850	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AR1Y2_RS07860	COG0583	DNA-binding transcription factor activity
AR1Y2_RS07865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AR1Y2_RS07870	COG1979	alcohol dehydrogenase
AR1Y2_RS07885	COG3854	ATPases associated with a variety of cellular activities
AR1Y2_RS07925	COG1302	Protein conserved in bacteria
AR1Y2_RS07935	COG1570	exodeoxyribonuclease VII activity
AR1Y2_RS07940	COG1722	exodeoxyribonuclease VII activity
AR1Y2_RS07950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AR1Y2_RS07955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AR1Y2_RS07960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AR1Y2_RS07965	COG1438	arginine binding
AR1Y2_RS07970	COG0497	DNA recombination
AR1Y2_RS07975	COG0750	zinc metalloprotease
AR1Y2_RS07980	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS07985	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS07990	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AR1Y2_RS08000	COG0124	histidyl-tRNA synthetase
AR1Y2_RS08005	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AR1Y2_RS08010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AR1Y2_RS08015	COG0131	Imidazoleglycerol-phosphate dehydratase
AR1Y2_RS08025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AR1Y2_RS08045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AR1Y2_RS08060	COG1702	phosphate starvation-inducible protein PhoH
AR1Y2_RS08065	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AR1Y2_RS08095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AR1Y2_RS08100	COG2081	HI0933 family
AR1Y2_RS08105	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AR1Y2_RS08110	COG1328	CTP reductase activity
AR1Y2_RS08115	COG0602	queuosine metabolic process
AR1Y2_RS08120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AR1Y2_RS08125	COG4224	UPF0291 protein
AR1Y2_RS08135	COG4656	Part of a membrane complex involved in electron transport
AR1Y2_RS08140	COG4658	electron transport chain
AR1Y2_RS08145	COG4659	FMN binding
AR1Y2_RS08150	COG4660	Part of a membrane complex involved in electron transport
AR1Y2_RS08155	COG4657	Part of a membrane complex involved in electron transport
AR1Y2_RS08160	COG2878	Part of a membrane complex involved in electron transport
AR1Y2_RS08165	COG1873	PFAM PRC-barrel domain
AR1Y2_RS08170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AR1Y2_RS08175	COG0606	chelatase, subunit chli
AR1Y2_RS08180	COG0758	DNA mediated transformation
AR1Y2_RS08185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AR1Y2_RS08195	COG0052	Belongs to the universal ribosomal protein uS2 family
AR1Y2_RS08200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AR1Y2_RS08215	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AR1Y2_RS08220	COG0784	Response regulator, receiver
AR1Y2_RS08220	COG2205	protein histidine kinase activity
AR1Y2_RS08250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AR1Y2_RS08255	COG3177	Filamentation induced by cAMP protein fic
AR1Y2_RS08270	COG0561	phosphatase activity
AR1Y2_RS08275	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS08290	COG2205	protein histidine kinase activity
AR1Y2_RS08315	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS08320	COG2205	protein histidine kinase activity
AR1Y2_RS08325	COG1136	(ABC) transporter
AR1Y2_RS08345	COG2226	methyltransferase
AR1Y2_RS08355	COG3620	sequence-specific DNA binding
AR1Y2_RS08375	COG1122	ATPase activity
AR1Y2_RS08380	COG1122	ATPase activity
AR1Y2_RS08385	COG0135	phosphoribosylanthranilate isomerase activity
AR1Y2_RS08390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AR1Y2_RS08405	COG1979	alcohol dehydrogenase
AR1Y2_RS08425	COG1309	transcriptional regulator
AR1Y2_RS08445	COG1609	Transcriptional regulator
AR1Y2_RS08445	COG2207	Transcriptional regulator
AR1Y2_RS08450	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AR1Y2_RS08455	COG1882	Formate acetyltransferase
AR1Y2_RS08460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AR1Y2_RS08465	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AR1Y2_RS08485	COG1335	isochorismatase
AR1Y2_RS08490	COG2188	Transcriptional regulator
AR1Y2_RS08495	COG3437	response regulator, receiver
AR1Y2_RS08505	COG0784	Response regulator, receiver
AR1Y2_RS08505	COG2205	protein histidine kinase activity
AR1Y2_RS08505	COG5002	protein histidine kinase activity
AR1Y2_RS08520	COG3711	transcriptional antiterminator
AR1Y2_RS08530	COG0246	Mannitol dehydrogenase
AR1Y2_RS08535	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AR1Y2_RS08540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AR1Y2_RS08545	COG1979	alcohol dehydrogenase
AR1Y2_RS08565	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS08570	COG5002	protein histidine kinase activity
AR1Y2_RS08575	COG1136	(ABC) transporter
AR1Y2_RS08575	COG0577	efflux transmembrane transporter activity
AR1Y2_RS08605	COG2203	Gaf domain
AR1Y2_RS08605	COG5001	Diguanylate cyclase
AR1Y2_RS08605	COG3706	GGDEF domain
AR1Y2_RS08605	COG4251	negative regulation of phosphorylation
AR1Y2_RS08610	COG1533	DNA photolyase activity
AR1Y2_RS08630	COG2155	Conserved Protein
AR1Y2_RS08650	COG0187	DNA topoisomerase II activity
AR1Y2_RS08655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AR1Y2_RS08690	COG0789	Transcriptional regulator
AR1Y2_RS08690	COG4978	Transcriptional regulator
AR1Y2_RS08700	COG1349	DNA-binding transcription factor activity
AR1Y2_RS08710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS08720	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS08725	COG1063	alcohol dehydrogenase
AR1Y2_RS08730	COG1349	DNA-binding transcription factor activity
AR1Y2_RS08745	COG0148	phosphopyruvate hydratase activity
AR1Y2_RS08750	COG1012	belongs to the aldehyde dehydrogenase family
AR1Y2_RS08760	COG0037	tRNA processing
AR1Y2_RS08765	COG1609	Transcriptional regulator
AR1Y2_RS08795	COG1131	(ABC) transporter
AR1Y2_RS08800	COG2205	protein histidine kinase activity
AR1Y2_RS08805	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS08815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AR1Y2_RS08855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AR1Y2_RS08860	COG4974	Belongs to the 'phage' integrase family
AR1Y2_RS08865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AR1Y2_RS08870	COG1304	FMN binding
AR1Y2_RS08890	COG0534	Mate efflux family protein
AR1Y2_RS08945	COG0196	riboflavin kinase activity
AR1Y2_RS08950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AR1Y2_RS08955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AR1Y2_RS08960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AR1Y2_RS08965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AR1Y2_RS08975	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AR1Y2_RS08980	COG0195	Participates in both transcription termination and antitermination
AR1Y2_RS08985	COG0779	Required for maturation of 30S ribosomal subunits
AR1Y2_RS08990	COG0210	DNA helicase
AR1Y2_RS09000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AR1Y2_RS09005	COG1121	(ABC) transporter
AR1Y2_RS09020	COG0095	Lipoate-protein ligase
AR1Y2_RS09030	COG1850	ribulose-bisphosphate carboxylase activity
AR1Y2_RS09035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS09040	COG3775	system Galactitol-specific IIC component
AR1Y2_RS09050	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS09065	COG0508	dehydrogenase complex catalyzes the overall conversion of
AR1Y2_RS09070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AR1Y2_RS09075	COG0022	dehydrogenase e1 component
AR1Y2_RS09080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AR1Y2_RS09090	COG1937	Protein conserved in bacteria
AR1Y2_RS09100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AR1Y2_RS09100	COG2199	diguanylate cyclase activity
AR1Y2_RS09110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AR1Y2_RS09115	COG0750	zinc metalloprotease
AR1Y2_RS09120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AR1Y2_RS09125	COG4589	Belongs to the CDS family
AR1Y2_RS09135	COG0233	cytoplasmic translational termination
AR1Y2_RS09140	COG0528	UMP kinase activity
AR1Y2_RS09145	COG1490	D-aminoacyl-tRNA deacylase activity
AR1Y2_RS09150	COG0402	S-adenosylhomocysteine deaminase activity
AR1Y2_RS09185	COG1012	belongs to the aldehyde dehydrogenase family
AR1Y2_RS09195	COG1394	ATPase activity, coupled to movement of substances
AR1Y2_RS09205	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AR1Y2_RS09225	COG1269	ATP hydrolysis coupled proton transport
AR1Y2_RS09275	COG0310	cobalt ion transport
AR1Y2_RS09290	COG1122	ATPase activity
AR1Y2_RS09320	COG3973	AAA domain
AR1Y2_RS09330	COG1136	(ABC) transporter
AR1Y2_RS09330	COG0577	efflux transmembrane transporter activity
AR1Y2_RS09335	COG2205	protein histidine kinase activity
AR1Y2_RS09365	COG3177	Filamentation induced by cAMP protein fic
AR1Y2_RS09375	COG5566	PFAM Mor transcription activator
AR1Y2_RS09390	COG0534	Mate efflux family protein
AR1Y2_RS09395	COG1309	transcriptional regulator
AR1Y2_RS09445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AR1Y2_RS09450	COG2946	Replication initiation factor
AR1Y2_RS09480	COG1492	cobalamin metabolic process
AR1Y2_RS09485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AR1Y2_RS09505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AR1Y2_RS09515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AR1Y2_RS09520	COG1797	cobyrinic acid a,c-diamide synthase activity
AR1Y2_RS09550	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AR1Y2_RS09555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AR1Y2_RS09560	COG0113	porphobilinogen synthase activity
AR1Y2_RS09565	COG0181	hydroxymethylbilane synthase activity
AR1Y2_RS09575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AR1Y2_RS09580	COG2199	diguanylate cyclase activity
AR1Y2_RS09580	COG2200	EAL domain
AR1Y2_RS09580	COG2202	Pas domain
AR1Y2_RS09600	COG0110	maltose O-acetyltransferase activity
AR1Y2_RS09605	COG2217	Heavy metal translocating P-type atpase
AR1Y2_RS09610	COG2217	Heavy metal translocating P-type atpase
AR1Y2_RS09615	COG0640	Transcriptional regulator
AR1Y2_RS09620	COG0693	protein deglycase activity
AR1Y2_RS09650	COG2211	Major facilitator Superfamily
AR1Y2_RS09655	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS09660	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS09665	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS09675	COG3447	MASE1 domain protein
AR1Y2_RS09675	COG5001	Diguanylate cyclase
AR1Y2_RS09675	COG5002	protein histidine kinase activity
AR1Y2_RS09700	COG3340	Belongs to the peptidase S51 family
AR1Y2_RS09740	COG0534	Mate efflux family protein
AR1Y2_RS09780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AR1Y2_RS09785	COG0551	DNA topoisomerase type I activity
AR1Y2_RS09785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AR1Y2_RS09795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AR1Y2_RS09810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AR1Y2_RS09815	COG0527	aspartate kinase activity
AR1Y2_RS09820	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AR1Y2_RS09835	COG0277	FAD linked oxidase domain protein
AR1Y2_RS09845	COG2086	electron transfer activity
AR1Y2_RS09855	COG4106	trans-aconitate 2-methyltransferase activity
AR1Y2_RS09875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AR1Y2_RS09895	COG3875	lactate racemase activity
AR1Y2_RS09900	COG1620	l-lactate permease
AR1Y2_RS09905	COG0124	histidyl-tRNA synthetase
AR1Y2_RS09915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AR1Y2_RS09920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AR1Y2_RS09925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AR1Y2_RS09935	COG0540	Belongs to the ATCase OTCase family
AR1Y2_RS09945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AR1Y2_RS09955	COG4968	Prepilin-type N-terminal cleavage methylation domain
AR1Y2_RS09960	COG1408	metallophosphoesterase
AR1Y2_RS09980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AR1Y2_RS09995	COG1459	type II secretion system
AR1Y2_RS10000	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AR1Y2_RS10050	COG5002	protein histidine kinase activity
AR1Y2_RS10065	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS10070	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AR1Y2_RS10075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AR1Y2_RS10080	COG2738	Putative neutral zinc metallopeptidase
AR1Y2_RS10090	COG0217	transcriptional regulatory protein
AR1Y2_RS10095	COG1253	flavin adenine dinucleotide binding
AR1Y2_RS10100	COG2337	Toxic component of a toxin-antitoxin (TA) module
AR1Y2_RS10105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AR1Y2_RS10110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AR1Y2_RS10110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AR1Y2_RS10115	COG0736	holo-[acyl-carrier-protein] synthase activity
AR1Y2_RS10125	COG0488	(ABC) transporter
AR1Y2_RS10130	COG1215	transferase activity, transferring glycosyl groups
AR1Y2_RS10135	COG0789	Transcriptional regulator
AR1Y2_RS10175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AR1Y2_RS10195	COG3843	relaxase mobilization nuclease domain protein
AR1Y2_RS10215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AR1Y2_RS10215	COG0551	DNA topoisomerase type I activity
AR1Y2_RS10235	COG0791	NLP P60 protein
AR1Y2_RS10235	COG0741	lytic transglycosylase activity
AR1Y2_RS10300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AR1Y2_RS10305	COG0481	GTPase activity
AR1Y2_RS10325	COG0268	Binds directly to 16S ribosomal RNA
AR1Y2_RS10340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AR1Y2_RS10345	COG3775	system Galactitol-specific IIC component
AR1Y2_RS10355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS10360	COG2390	Transcriptional regulator
AR1Y2_RS10370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AR1Y2_RS10375	COG3958	Transketolase
AR1Y2_RS10390	COG0583	DNA-binding transcription factor activity
AR1Y2_RS10410	COG2333	competence protein COMEC
AR1Y2_RS10410	COG0658	competence protein
AR1Y2_RS10425	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS10440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AR1Y2_RS10445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AR1Y2_RS10450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AR1Y2_RS10455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AR1Y2_RS10460	COG0137	argininosuccinate synthase activity
AR1Y2_RS10465	COG2949	membrane
AR1Y2_RS10470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AR1Y2_RS10470	COG0551	DNA topoisomerase type I activity
AR1Y2_RS10485	COG0165	Argininosuccinate lyase
AR1Y2_RS10510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AR1Y2_RS10515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AR1Y2_RS10520	COG0028	Belongs to the TPP enzyme family
AR1Y2_RS10525	COG0129	dihydroxy-acid dehydratase activity
AR1Y2_RS10530	COG0473	3-isopropylmalate dehydrogenase activity
AR1Y2_RS10545	COG0860	N-Acetylmuramoyl-L-alanine amidase
AR1Y2_RS10550	COG0860	N-Acetylmuramoyl-L-alanine amidase
AR1Y2_RS10560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AR1Y2_RS10565	COG0799	negative regulation of ribosome biogenesis
AR1Y2_RS10570	COG1713	HD superfamily hydrolase involved in NAD metabolism
AR1Y2_RS10575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AR1Y2_RS10580	COG1534	Rna-binding protein
AR1Y2_RS10585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AR1Y2_RS10590	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AR1Y2_RS10595	COG2868	ribosomal protein
AR1Y2_RS10605	COG1530	ribonuclease E activity
AR1Y2_RS10610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AR1Y2_RS10635	COG0714	Associated with various cellular activities
AR1Y2_RS10640	COG1757	Na H antiporter
AR1Y2_RS10645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AR1Y2_RS10655	COG0235	Class ii aldolase
AR1Y2_RS10660	COG4806	L-rhamnose isomerase
AR1Y2_RS10665	COG1070	Carbohydrate kinase
AR1Y2_RS10670	COG3254	rhamnose metabolic process
AR1Y2_RS10685	COG2161	toxin-antitoxin pair type II binding
AR1Y2_RS10695	COG0352	thiamine-phosphate diphosphorylase activity
AR1Y2_RS10695	COG0351	phosphomethylpyrimidine kinase
AR1Y2_RS10705	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AR1Y2_RS10740	COG1136	(ABC) transporter
AR1Y2_RS10740	COG0577	efflux transmembrane transporter activity
AR1Y2_RS10745	COG5002	protein histidine kinase activity
AR1Y2_RS10750	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS10795	COG1979	alcohol dehydrogenase
AR1Y2_RS10810	COG1136	(ABC) transporter
AR1Y2_RS10830	COG0534	Mate efflux family protein
AR1Y2_RS10840	COG0583	DNA-binding transcription factor activity
AR1Y2_RS10845	COG2814	Major facilitator Superfamily
AR1Y2_RS10850	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AR1Y2_RS10875	COG1131	(ABC) transporter
AR1Y2_RS10925	COG1309	transcriptional regulator
AR1Y2_RS10935	COG2378	regulation of single-species biofilm formation
AR1Y2_RS10945	COG0561	phosphatase activity
AR1Y2_RS10950	COG0495	leucyl-tRNA aminoacylation
AR1Y2_RS10955	COG1376	ErfK ybiS ycfS ynhG family protein
AR1Y2_RS10965	COG1362	aminopeptidase activity
AR1Y2_RS10970	COG1393	Belongs to the ArsC family
AR1Y2_RS10975	COG1686	Belongs to the peptidase S11 family
AR1Y2_RS10980	COG2199	diguanylate cyclase activity
AR1Y2_RS10985	COG3300	MHYT domain
AR1Y2_RS10985	COG5001	Diguanylate cyclase
AR1Y2_RS10990	COG0275	rRNA processing
AR1Y2_RS11000	COG0427	acetyl-CoA hydrolase
AR1Y2_RS11005	COG0039	L-malate dehydrogenase activity
AR1Y2_RS11035	COG1388	LysM domain
AR1Y2_RS11035	COG3858	chitin binding
AR1Y2_RS11055	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AR1Y2_RS11075	COG0739	heme binding
AR1Y2_RS11085	COG1653	transport
AR1Y2_RS11090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AR1Y2_RS11105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AR1Y2_RS11120	COG0275	rRNA processing
AR1Y2_RS11130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AR1Y2_RS11140	COG1476	TRANSCRIPTIONal
AR1Y2_RS11150	COG2086	electron transfer activity
AR1Y2_RS11155	COG1960	acyl-CoA dehydrogenase activity
AR1Y2_RS11160	COG1250	3-hydroxyacyl-CoA dehydrogenase
AR1Y2_RS11165	COG1024	Enoyl-CoA hydratase
AR1Y2_RS11170	COG0183	Belongs to the thiolase family
AR1Y2_RS11180	COG0071	Belongs to the small heat shock protein (HSP20) family
AR1Y2_RS11185	COG0440	acetolactate synthase activity
AR1Y2_RS11190	COG0028	Belongs to the TPP enzyme family
AR1Y2_RS11205	COG1408	metallophosphoesterase
AR1Y2_RS11215	COG3732	PTS system glucitol sorbitol-specific
AR1Y2_RS11220	COG3730	PTS system glucitol sorbitol-specific
AR1Y2_RS11230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS11230	COG3711	transcriptional antiterminator
AR1Y2_RS11240	COG1686	Belongs to the peptidase S11 family
AR1Y2_RS11260	COG0826	peptidase U32
AR1Y2_RS11270	COG2255	four-way junction helicase activity
AR1Y2_RS11275	COG0632	four-way junction helicase activity
AR1Y2_RS11290	COG1346	cytolysis
AR1Y2_RS11295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AR1Y2_RS11315	COG2801	Transposase and inactivated derivatives
AR1Y2_RS11350	COG2002	toxin-antitoxin pair type II binding
AR1Y2_RS11365	COG0789	Transcriptional regulator
AR1Y2_RS11370	COG2873	o-acetylhomoserine
AR1Y2_RS11375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AR1Y2_RS11380	COG4120	Belongs to the binding-protein-dependent transport system permease family
AR1Y2_RS11395	COG1185	polyribonucleotide nucleotidyltransferase activity
AR1Y2_RS11400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AR1Y2_RS11405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AR1Y2_RS11410	COG0564	pseudouridine synthase activity
AR1Y2_RS11415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AR1Y2_RS11420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AR1Y2_RS11435	COG1799	cell septum assembly
AR1Y2_RS11440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AR1Y2_RS11450	COG1242	4 iron, 4 sulfur cluster binding
AR1Y2_RS11455	COG1686	Belongs to the peptidase S11 family
AR1Y2_RS11460	COG1803	Methylglyoxal synthase
AR1Y2_RS11465	COG0772	Belongs to the SEDS family
AR1Y2_RS11470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AR1Y2_RS11475	COG2894	cell division
AR1Y2_RS11480	COG0850	regulation of cytokinetic process
AR1Y2_RS11485	COG0768	penicillin binding
AR1Y2_RS11500	COG1077	Cell shape determining protein MreB Mrl
AR1Y2_RS11505	COG2003	Belongs to the UPF0758 family
AR1Y2_RS11510	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AR1Y2_RS11515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AR1Y2_RS11520	COG0295	cytidine deaminase activity
AR1Y2_RS11530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AR1Y2_RS11535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AR1Y2_RS11540	COG0562	UDP-galactopyranose mutase
AR1Y2_RS11545	COG1283	sodium-dependent phosphate transmembrane transporter activity
AR1Y2_RS11555	COG0058	SHG alpha-glucan phosphorylase activity
AR1Y2_RS11560	COG0297	glycogen (starch) synthase activity
AR1Y2_RS11565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AR1Y2_RS11570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AR1Y2_RS11575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AR1Y2_RS11580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AR1Y2_RS11585	COG0552	protein localization to endoplasmic reticulum
AR1Y2_RS11590	COG1196	nuclear chromosome segregation
AR1Y2_RS11595	COG0571	ribonuclease III activity
AR1Y2_RS11600	COG0416	fatty acid biosynthetic process
AR1Y2_RS11605	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AR1Y2_RS11615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AR1Y2_RS11620	COG0280	phosphate acetyltransferase
AR1Y2_RS11630	COG3314	Sporulation integral membrane protein YlbJ
AR1Y2_RS11640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AR1Y2_RS11645	COG0742	ribosomal rna small subunit methyltransferase
AR1Y2_RS11655	COG1254	Belongs to the acylphosphatase family
AR1Y2_RS11660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AR1Y2_RS11665	COG1461	Dihydroxyacetone kinase
AR1Y2_RS11675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AR1Y2_RS11720	COG0583	DNA-binding transcription factor activity
AR1Y2_RS11730	COG1725	Transcriptional regulator
AR1Y2_RS11735	COG1131	(ABC) transporter
AR1Y2_RS11750	COG0107	imidazoleglycerol-phosphate synthase activity
AR1Y2_RS11755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AR1Y2_RS11765	COG5002	protein histidine kinase activity
AR1Y2_RS11770	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS11780	COG0561	phosphatase activity
AR1Y2_RS11790	COG0482	sulfurtransferase activity
AR1Y2_RS11795	COG0822	iron-sulfur transferase activity
AR1Y2_RS11805	COG1959	2 iron, 2 sulfur cluster binding
AR1Y2_RS11810	COG2244	polysaccharide biosynthetic process
AR1Y2_RS11815	COG1079	Belongs to the binding-protein-dependent transport system permease family
AR1Y2_RS11820	COG4603	Belongs to the binding-protein-dependent transport system permease family
AR1Y2_RS11825	COG3845	ABC transporter
AR1Y2_RS11875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AR1Y2_RS11885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AR1Y2_RS11895	COG0215	cysteine-tRNA ligase activity
AR1Y2_RS11900	COG1045	serine acetyltransferase
AR1Y2_RS11920	COG1268	BioY protein
AR1Y2_RS11925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AR1Y2_RS11950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AR1Y2_RS11955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AR1Y2_RS11960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AR1Y2_RS11965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AR1Y2_RS11975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AR1Y2_RS11980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AR1Y2_RS11990	COG0356	it plays a direct role in the translocation of protons across the membrane
AR1Y2_RS12045	COG0210	DNA helicase
AR1Y2_RS12055	COG4496	protein, YerC YecD
AR1Y2_RS12060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AR1Y2_RS12075	COG1131	(ABC) transporter
AR1Y2_RS12080	COG4585	Histidine kinase
AR1Y2_RS12090	COG4536	flavin adenine dinucleotide binding
AR1Y2_RS12100	COG0210	DNA helicase
AR1Y2_RS12105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AR1Y2_RS12110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AR1Y2_RS12135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AR1Y2_RS12140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS12145	COG3711	transcriptional antiterminator
AR1Y2_RS12150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AR1Y2_RS12175	COG1737	Transcriptional regulator
AR1Y2_RS12195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS12200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS12210	COG0534	Mate efflux family protein
AR1Y2_RS12225	COG0725	ABC transporter, periplasmic molybdate-binding protein
AR1Y2_RS12230	COG4149	molybdate abc transporter
AR1Y2_RS12240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AR1Y2_RS12245	COG3608	succinylglutamate desuccinylase aspartoacylase
AR1Y2_RS12245	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AR1Y2_RS12250	COG0024	Methionine aminopeptidase
AR1Y2_RS12260	COG1131	(ABC) transporter
AR1Y2_RS12270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AR1Y2_RS12295	COG1131	(ABC) transporter
AR1Y2_RS12320	COG3300	MHYT domain
AR1Y2_RS12320	COG5001	Diguanylate cyclase
AR1Y2_RS12330	COG1307	EDD domain protein, DegV family
AR1Y2_RS12335	COG0521	Mo-molybdopterin cofactor biosynthetic process
AR1Y2_RS12355	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AR1Y2_RS12355	COG3608	succinylglutamate desuccinylase aspartoacylase
AR1Y2_RS12375	COG0493	'glutamate synthase
AR1Y2_RS12375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AR1Y2_RS12380	COG0402	S-adenosylhomocysteine deaminase activity
AR1Y2_RS12395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AR1Y2_RS12400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AR1Y2_RS12405	COG0549	Belongs to the carbamate kinase family
AR1Y2_RS12410	COG0584	glycerophosphoryl diester phosphodiesterase
AR1Y2_RS12425	COG0789	Transcriptional regulator
AR1Y2_RS12445	COG3620	sequence-specific DNA binding
AR1Y2_RS12465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AR1Y2_RS12480	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AR1Y2_RS12490	COG1979	alcohol dehydrogenase
AR1Y2_RS12495	COG2390	Transcriptional regulator
AR1Y2_RS12500	COG3715	PTS system
AR1Y2_RS12505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS12510	COG1063	alcohol dehydrogenase
AR1Y2_RS12555	COG2378	regulation of single-species biofilm formation
AR1Y2_RS12565	COG0546	phosphoglycolate phosphatase activity
AR1Y2_RS12570	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
AR1Y2_RS12575	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS12580	COG4702	Belongs to the UPF0303 family
AR1Y2_RS12590	COG1063	alcohol dehydrogenase
AR1Y2_RS12600	COG3775	system Galactitol-specific IIC component
AR1Y2_RS12605	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS12615	COG3711	transcriptional antiterminator
AR1Y2_RS12615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS12625	COG1242	4 iron, 4 sulfur cluster binding
AR1Y2_RS12640	COG0371	Dehydrogenase
AR1Y2_RS12645	COG0698	ribose 5-phosphate isomerase
AR1Y2_RS12650	COG3732	PTS system glucitol sorbitol-specific
AR1Y2_RS12655	COG3730	PTS system glucitol sorbitol-specific
AR1Y2_RS12670	COG0561	phosphatase activity
AR1Y2_RS12685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AR1Y2_RS12715	COG2815	serine threonine protein kinase
AR1Y2_RS12715	COG0515	serine threonine protein kinase
AR1Y2_RS12720	COG0631	protein serine/threonine phosphatase activity
AR1Y2_RS12725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AR1Y2_RS12730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AR1Y2_RS12730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AR1Y2_RS12735	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AR1Y2_RS12740	COG0242	peptide deformylase activity
AR1Y2_RS12745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AR1Y2_RS12750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AR1Y2_RS12765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AR1Y2_RS12770	COG0688	phosphatidylethanolamine metabolic process
AR1Y2_RS12775	COG1183	phosphatidylcholine synthase activity
AR1Y2_RS12790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AR1Y2_RS12800	COG0517	IMP dehydrogenase activity
AR1Y2_RS12800	COG0516	GMP reductase activity
AR1Y2_RS12810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AR1Y2_RS12810	COG0493	'glutamate synthase
AR1Y2_RS12825	COG0459	protein refolding
AR1Y2_RS12830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AR1Y2_RS12840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AR1Y2_RS12845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AR1Y2_RS12855	COG0542	response to heat
AR1Y2_RS12865	COG0151	Belongs to the GarS family
AR1Y2_RS12870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AR1Y2_RS12875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AR1Y2_RS12880	COG0860	N-Acetylmuramoyl-L-alanine amidase
AR1Y2_RS12880	COG1388	LysM domain
AR1Y2_RS12885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AR1Y2_RS12910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AR1Y2_RS12920	COG0167	dihydroorotate dehydrogenase activity
AR1Y2_RS12925	COG0543	2 iron, 2 sulfur cluster binding
AR1Y2_RS12935	COG5002	protein histidine kinase activity
AR1Y2_RS12945	COG0704	Plays a role in the regulation of phosphate uptake
AR1Y2_RS12950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AR1Y2_RS12955	COG0581	inorganic phosphate transmembrane transporter activity
AR1Y2_RS12960	COG0573	inorganic phosphate transmembrane transporter activity
AR1Y2_RS12975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AR1Y2_RS12990	COG3775	system Galactitol-specific IIC component
AR1Y2_RS12995	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS13000	COG1063	alcohol dehydrogenase
AR1Y2_RS13020	COG0423	glycine-tRNA ligase activity
AR1Y2_RS13025	COG1381	Involved in DNA repair and RecF pathway recombination
AR1Y2_RS13030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AR1Y2_RS13055	COG0789	Transcriptional regulator
AR1Y2_RS13060	COG0138	bifunctional purine biosynthesis protein purh
AR1Y2_RS13080	COG3757	hydrolase, family 25
AR1Y2_RS13085	COG1191	sigma factor activity
AR1Y2_RS13095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AR1Y2_RS13105	COG0772	Belongs to the SEDS family
AR1Y2_RS13110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AR1Y2_RS13120	COG0768	penicillin binding
AR1Y2_RS13130	COG0768	penicillin binding
AR1Y2_RS13145	COG2001	Belongs to the MraZ family
AR1Y2_RS13155	COG0012	GTP binding
AR1Y2_RS13160	COG0791	NLP P60 protein
AR1Y2_RS13165	COG0436	Aminotransferase
AR1Y2_RS13180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AR1Y2_RS13200	COG0393	Putative heavy-metal-binding
AR1Y2_RS13285	COG2002	toxin-antitoxin pair type II binding
AR1Y2_RS13325	COG0791	NLP P60 protein
AR1Y2_RS13330	COG1652	LysM domain
AR1Y2_RS13475	COG1192	Involved in chromosome partitioning
AR1Y2_RS13490	COG0328	RNA-DNA hybrid ribonuclease activity
AR1Y2_RS13525	COG1476	TRANSCRIPTIONal
AR1Y2_RS13545	COG4978	Transcriptional regulator
AR1Y2_RS13545	COG0789	Transcriptional regulator
AR1Y2_RS13560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AR1Y2_RS13590	COG0436	Aminotransferase
AR1Y2_RS13595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AR1Y2_RS13600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AR1Y2_RS13615	COG1217	gtp-binding protein TYPA
AR1Y2_RS13625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AR1Y2_RS13645	COG1131	(ABC) transporter
AR1Y2_RS13660	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AR1Y2_RS13670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AR1Y2_RS13680	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS13685	COG1132	(ABC) transporter
AR1Y2_RS13695	COG1846	Transcriptional regulator
AR1Y2_RS13715	COG0653	protein targeting
AR1Y2_RS13725	COG0784	Response regulator, receiver
AR1Y2_RS13725	COG2205	protein histidine kinase activity
AR1Y2_RS13730	COG1725	Transcriptional regulator
AR1Y2_RS13735	COG2365	Tyrosine phosphatase family
AR1Y2_RS13745	COG0656	L-ascorbic acid biosynthetic process
AR1Y2_RS13750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AR1Y2_RS13760	COG1609	Transcriptional regulator
AR1Y2_RS13765	COG1686	Belongs to the peptidase S11 family
AR1Y2_RS13775	COG0523	cobalamin synthesis protein
AR1Y2_RS13800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AR1Y2_RS13805	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AR1Y2_RS13810	COG2080	2 iron, 2 sulfur cluster binding
AR1Y2_RS13830	COG1349	DNA-binding transcription factor activity
AR1Y2_RS13835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS13835	COG2213	PTS system mannitol-specific
AR1Y2_RS13840	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS13845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AR1Y2_RS13850	COG2390	Transcriptional regulator
AR1Y2_RS13870	COG0561	phosphatase activity
AR1Y2_RS13900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AR1Y2_RS13905	COG2890	protein-(glutamine-N5) methyltransferase activity
AR1Y2_RS13910	COG3872	metal-dependent enzyme
AR1Y2_RS13915	COG0254	rRNA binding
AR1Y2_RS13920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AR1Y2_RS13930	COG2172	sigma factor antagonist activity
AR1Y2_RS13945	COG0285	dihydrofolate synthase activity
AR1Y2_RS13950	COG0525	valine-tRNA ligase activity
AR1Y2_RS13975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AR1Y2_RS14000	COG0372	Belongs to the citrate synthase family
AR1Y2_RS14005	COG1126	abc transporter atp-binding protein
AR1Y2_RS14015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AR1Y2_RS14025	COG4193	domain, Protein
AR1Y2_RS14045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AR1Y2_RS14050	COG0159	tryptophan synthase activity
AR1Y2_RS14055	COG0133	tryptophan synthase activity
AR1Y2_RS14060	COG0135	phosphoribosylanthranilate isomerase activity
AR1Y2_RS14065	COG0134	indole-3-glycerol-phosphate synthase activity
AR1Y2_RS14070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AR1Y2_RS14070	COG0512	Glutamine amidotransferase of anthranilate synthase
AR1Y2_RS14095	COG0493	'glutamate synthase
AR1Y2_RS14095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AR1Y2_RS14120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AR1Y2_RS14135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AR1Y2_RS14150	COG0427	acetyl-CoA hydrolase
AR1Y2_RS14160	COG1454	alcohol dehydrogenase
AR1Y2_RS14165	COG2030	dehydratase
AR1Y2_RS14170	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AR1Y2_RS14180	COG1735	metal-dependent hydrolase with the TIM-barrel fold
AR1Y2_RS14185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AR1Y2_RS14195	COG3775	system Galactitol-specific IIC component
AR1Y2_RS14210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS14210	COG3711	transcriptional antiterminator
AR1Y2_RS14220	COG1063	alcohol dehydrogenase
AR1Y2_RS14250	COG0463	Glycosyl transferase, family 2
AR1Y2_RS14250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AR1Y2_RS14255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AR1Y2_RS14260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AR1Y2_RS14280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AR1Y2_RS14280	COG0463	Glycosyl transferase, family 2
AR1Y2_RS14290	COG0463	Glycosyl transferase, family 2
AR1Y2_RS14315	COG1216	Glycosyl transferase, family 2
AR1Y2_RS14325	COG5039	Polysaccharide pyruvyl transferase
AR1Y2_RS14345	COG1083	cytidylyl-transferase
AR1Y2_RS14350	COG2089	acid synthase
AR1Y2_RS14360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AR1Y2_RS14365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AR1Y2_RS14370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AR1Y2_RS14375	COG1216	Glycosyl transferase, family 2
AR1Y2_RS14375	COG1442	glycosyl transferase family 8
AR1Y2_RS14385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AR1Y2_RS14390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AR1Y2_RS14400	COG1404	Belongs to the peptidase S8 family
AR1Y2_RS14410	COG4485	Bacterial membrane protein, YfhO
AR1Y2_RS14415	COG2246	polysaccharide biosynthetic process
AR1Y2_RS14425	COG0463	Glycosyl transferase, family 2
AR1Y2_RS14430	COG4856	YbbR-like protein
AR1Y2_RS14435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AR1Y2_RS14465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AR1Y2_RS14470	COG0463	Glycosyl transferase, family 2
AR1Y2_RS14475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AR1Y2_RS14490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AR1Y2_RS14490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AR1Y2_RS14495	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AR1Y2_RS14510	COG0765	amino acid transport
AR1Y2_RS14515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AR1Y2_RS14530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AR1Y2_RS14540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AR1Y2_RS14560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AR1Y2_RS14575	COG0733	neurotransmitter:sodium symporter activity
AR1Y2_RS14580	COG2205	protein histidine kinase activity
AR1Y2_RS14585	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS14600	COG0076	glutamate decarboxylase activity
AR1Y2_RS14660	COG1652	LysM domain
AR1Y2_RS14725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS14730	COG1481	regulation of sporulation
AR1Y2_RS14740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AR1Y2_RS14745	COG1940	carbohydrate kinase activity
AR1Y2_RS14750	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AR1Y2_RS14755	COG0322	excinuclease ABC activity
AR1Y2_RS14760	COG2217	Heavy metal translocating P-type atpase
AR1Y2_RS14775	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AR1Y2_RS14800	COG5002	protein histidine kinase activity
AR1Y2_RS14845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AR1Y2_RS14850	COG0733	neurotransmitter:sodium symporter activity
AR1Y2_RS14860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AR1Y2_RS14865	COG1882	Formate acetyltransferase
AR1Y2_RS14870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS14875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS14880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS14880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS14880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS14885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AR1Y2_RS14890	COG3711	transcriptional antiterminator
AR1Y2_RS14890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS14905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AR1Y2_RS14920	COG1070	Carbohydrate kinase
AR1Y2_RS14930	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS14940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS14940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS14945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS14960	COG0583	DNA-binding transcription factor activity
AR1Y2_RS14975	COG0191	fructose-bisphosphate aldolase activity
AR1Y2_RS14985	COG3775	system Galactitol-specific IIC component
AR1Y2_RS14990	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS15000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS15005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS15005	COG3711	transcriptional antiterminator
AR1Y2_RS15025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AR1Y2_RS15030	COG1283	sodium-dependent phosphate transmembrane transporter activity
AR1Y2_RS15035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS15035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS15035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS15040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS15045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS15090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AR1Y2_RS15095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AR1Y2_RS15100	COG0561	phosphatase activity
AR1Y2_RS15110	COG1309	transcriptional regulator
AR1Y2_RS15115	COG2814	Major facilitator Superfamily
AR1Y2_RS15120	COG1489	DNA binding
AR1Y2_RS15130	COG1116	anion transmembrane transporter activity
AR1Y2_RS15135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AR1Y2_RS15150	COG1882	Formate acetyltransferase
AR1Y2_RS15160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AR1Y2_RS15175	COG4977	sequence-specific DNA binding
AR1Y2_RS15180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AR1Y2_RS15190	COG1309	transcriptional regulator
AR1Y2_RS15200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AR1Y2_RS15200	COG1013	pyruvate-flavodoxin oxidoreductase activity
AR1Y2_RS15200	COG0674	pyruvate-flavodoxin oxidoreductase activity
AR1Y2_RS15200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AR1Y2_RS15210	COG3829	transcription factor binding
AR1Y2_RS15215	COG1979	alcohol dehydrogenase
AR1Y2_RS15220	COG0534	Mate efflux family protein
AR1Y2_RS15225	COG1811	Na channel or pump
AR1Y2_RS15240	COG0477	Major facilitator Superfamily
AR1Y2_RS15255	COG5001	Diguanylate cyclase
AR1Y2_RS15270	COG2244	polysaccharide biosynthetic process
AR1Y2_RS15290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AR1Y2_RS15295	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AR1Y2_RS15305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS15310	COG3711	transcriptional antiterminator
AR1Y2_RS15320	COG1349	DNA-binding transcription factor activity
AR1Y2_RS15325	COG1063	alcohol dehydrogenase
AR1Y2_RS15335	COG2213	PTS system mannitol-specific
AR1Y2_RS15335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS15345	COG1063	alcohol dehydrogenase
AR1Y2_RS15355	COG0504	CTP synthase activity
AR1Y2_RS15370	COG2376	Dihydroxyacetone kinase
AR1Y2_RS15380	COG0698	ribose 5-phosphate isomerase
AR1Y2_RS15385	COG0546	phosphoglycolate phosphatase activity
AR1Y2_RS15395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS15400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS15405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS15405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS15405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS15420	COG0791	NLP P60 protein
AR1Y2_RS15420	COG0741	lytic transglycosylase activity
AR1Y2_RS15430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AR1Y2_RS15470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AR1Y2_RS15475	COG0741	lytic transglycosylase activity
AR1Y2_RS15475	COG0791	NLP P60 protein
AR1Y2_RS15560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AR1Y2_RS15570	COG1234	tRNA 3'-trailer cleavage
AR1Y2_RS15575	COG0456	acetyltransferase
AR1Y2_RS15580	COG1214	PFAM Peptidase M22, glycoprotease
AR1Y2_RS15585	COG0802	atpase or kinase
AR1Y2_RS15595	COG2002	toxin-antitoxin pair type II binding
AR1Y2_RS15610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AR1Y2_RS15625	COG3850	Histidine kinase
AR1Y2_RS15625	COG4999	Histidine kinase
AR1Y2_RS15625	COG3437	response regulator, receiver
AR1Y2_RS15625	COG2205	protein histidine kinase activity
AR1Y2_RS15645	COG0793	Belongs to the peptidase S41A family
AR1Y2_RS15650	COG2610	gluconate transmembrane transporter activity
AR1Y2_RS15660	COG2030	dehydratase
AR1Y2_RS15665	COG0583	DNA-binding transcription factor activity
AR1Y2_RS15670	COG0739	heme binding
AR1Y2_RS15675	COG2177	Part of the ABC transporter FtsEX involved in
AR1Y2_RS15680	COG2884	Cell division ATP-binding protein ftsE
AR1Y2_RS15685	COG3835	regulator
AR1Y2_RS15690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AR1Y2_RS15700	COG0300	oxidoreductase activity
AR1Y2_RS15705	COG2183	response to ionizing radiation
AR1Y2_RS15720	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AR1Y2_RS15725	COG0460	homoserine dehydrogenase
AR1Y2_RS15730	COG4492	Belongs to the UPF0735 family
AR1Y2_RS15750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AR1Y2_RS15755	COG0653	protein targeting
AR1Y2_RS15760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AR1Y2_RS15765	COG0492	ferredoxin-NADP+ reductase activity
AR1Y2_RS15775	COG0697	spore germination
AR1Y2_RS15780	COG1917	Cupin 2, conserved barrel domain protein
AR1Y2_RS15780	COG2207	Transcriptional regulator
AR1Y2_RS15785	COG0640	Transcriptional regulator
AR1Y2_RS15795	COG2252	PERMEase
AR1Y2_RS15800	COG0488	(ABC) transporter
AR1Y2_RS15815	COG1285	pathogenesis
AR1Y2_RS15840	COG1263	PTS System
AR1Y2_RS15840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS15840	COG2190	(PTS) system
AR1Y2_RS15850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS15850	COG1263	PTS System
AR1Y2_RS15850	COG2190	(PTS) system
AR1Y2_RS15865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AR1Y2_RS15870	COG1328	CTP reductase activity
AR1Y2_RS15870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AR1Y2_RS15875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AR1Y2_RS15880	COG0101	tRNA pseudouridine synthase activity
AR1Y2_RS15885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AR1Y2_RS15890	COG1122	ATPase activity
AR1Y2_RS15895	COG1122	ATPase activity
AR1Y2_RS15905	COG0203	ribosomal protein L17
AR1Y2_RS15910	COG0202	RNA polymerase activity
AR1Y2_RS15915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AR1Y2_RS15920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AR1Y2_RS15930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AR1Y2_RS15935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AR1Y2_RS15960	COG1841	ribosomal large subunit assembly
AR1Y2_RS15975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AR1Y2_RS15980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AR1Y2_RS15985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AR1Y2_RS15990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AR1Y2_RS15995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AR1Y2_RS16000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AR1Y2_RS16005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AR1Y2_RS16010	COG0255	Belongs to the universal ribosomal protein uL29 family
AR1Y2_RS16015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AR1Y2_RS16025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AR1Y2_RS16035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AR1Y2_RS16050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AR1Y2_RS16055	COG0051	transcription antitermination factor activity, RNA binding
AR1Y2_RS16070	COG0656	L-ascorbic acid biosynthetic process
AR1Y2_RS16085	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AR1Y2_RS16090	COG2376	Dihydroxyacetone kinase
AR1Y2_RS16095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AR1Y2_RS16100	COG1349	DNA-binding transcription factor activity
AR1Y2_RS16115	COG0825	malonyl-CoA metabolic process
AR1Y2_RS16120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AR1Y2_RS16125	COG0439	Biotin carboxylase
AR1Y2_RS16135	COG0511	ligase activity, forming carbon-carbon bonds
AR1Y2_RS16140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AR1Y2_RS16145	COG1028	Short-chain dehydrogenase reductase Sdr
AR1Y2_RS16150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AR1Y2_RS16155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AR1Y2_RS16160	COG1063	alcohol dehydrogenase
AR1Y2_RS16185	COG1592	Rubrerythrin
AR1Y2_RS16185	COG1773	rubredoxin
AR1Y2_RS16195	COG0513	Belongs to the DEAD box helicase family
AR1Y2_RS16205	COG1342	Belongs to the UPF0251 family
AR1Y2_RS16225	COG2385	sporulation resulting in formation of a cellular spore
AR1Y2_RS16235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AR1Y2_RS16245	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AR1Y2_RS16250	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS16255	COG3715	PTS system
AR1Y2_RS16260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS16270	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AR1Y2_RS16270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AR1Y2_RS16280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AR1Y2_RS16285	COG0204	Acyl-transferase
AR1Y2_RS16295	COG3711	transcriptional antiterminator
AR1Y2_RS16295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS16305	COG3775	system Galactitol-specific IIC component
AR1Y2_RS16310	COG3414	Phosphotransferase system galactitol-specific IIB component
AR1Y2_RS16315	COG1063	alcohol dehydrogenase
AR1Y2_RS16325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AR1Y2_RS16335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AR1Y2_RS16340	COG0564	pseudouridine synthase activity
AR1Y2_RS16345	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS16350	COG5002	protein histidine kinase activity
AR1Y2_RS16355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AR1Y2_RS16360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AR1Y2_RS16365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AR1Y2_RS16370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AR1Y2_RS16385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AR1Y2_RS16390	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AR1Y2_RS16420	COG0488	(ABC) transporter
AR1Y2_RS16435	COG1349	DNA-binding transcription factor activity
AR1Y2_RS16445	COG1737	Transcriptional regulator
AR1Y2_RS16450	COG1263	PTS System
AR1Y2_RS16450	COG2190	(PTS) system
AR1Y2_RS16450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS16455	COG1486	melibiose metabolic process
AR1Y2_RS16465	COG1263	PTS System
AR1Y2_RS16465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS16475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AR1Y2_RS16480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AR1Y2_RS16485	COG2207	Transcriptional regulator
AR1Y2_RS16485	COG3708	Transcriptional regulator
AR1Y2_RS16490	COG0860	N-Acetylmuramoyl-L-alanine amidase
AR1Y2_RS16490	COG1388	LysM domain
AR1Y2_RS16500	COG0726	polysaccharide deacetylase
AR1Y2_RS16505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AR1Y2_RS16510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AR1Y2_RS16520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AR1Y2_RS16525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AR1Y2_RS16530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AR1Y2_RS16535	COG0537	adenosine 5'-monophosphoramidase activity
AR1Y2_RS16540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AR1Y2_RS16545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AR1Y2_RS16550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AR1Y2_RS16555	COG3290	protein histidine kinase activity
AR1Y2_RS16560	COG0457	Tetratricopeptide repeat
AR1Y2_RS16560	COG0705	Rhomboid family
AR1Y2_RS16615	COG0159	tryptophan synthase activity
AR1Y2_RS16620	COG3037	sugar-specific permease SgaT UlaA
AR1Y2_RS16630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS16640	COG4086	secreted protein
AR1Y2_RS16655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AR1Y2_RS16670	COG0765	amino acid transport
AR1Y2_RS16675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AR1Y2_RS16680	COG1464	Belongs to the NlpA lipoprotein family
AR1Y2_RS16685	COG1194	a g-specific adenine glycosylase
AR1Y2_RS16690	COG1040	competence protein
AR1Y2_RS16720	COG3732	PTS system glucitol sorbitol-specific
AR1Y2_RS16725	COG3730	PTS system glucitol sorbitol-specific
AR1Y2_RS16750	COG1349	DNA-binding transcription factor activity
AR1Y2_RS16755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AR1Y2_RS16755	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS16760	COG3715	PTS system
AR1Y2_RS16770	COG1349	DNA-binding transcription factor activity
AR1Y2_RS16775	COG0686	Belongs to the AlaDH PNT family
AR1Y2_RS16795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AR1Y2_RS16805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AR1Y2_RS16805	COG0116	Belongs to the methyltransferase superfamily
AR1Y2_RS16815	COG0726	polysaccharide deacetylase
AR1Y2_RS16820	COG3437	response regulator, receiver
AR1Y2_RS16825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AR1Y2_RS16830	COG2390	Transcriptional regulator
AR1Y2_RS16850	COG1704	LemA family
AR1Y2_RS16860	COG1773	rubredoxin
AR1Y2_RS16860	COG1592	Rubrerythrin
AR1Y2_RS16880	COG1253	flavin adenine dinucleotide binding
AR1Y2_RS16890	COG1607	acyl-coa hydrolase
AR1Y2_RS16900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AR1Y2_RS16910	COG2086	electron transfer activity
AR1Y2_RS16915	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AR1Y2_RS16920	COG1960	acyl-CoA dehydrogenase activity
AR1Y2_RS16960	COG0167	dihydroorotate dehydrogenase activity
AR1Y2_RS16960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AR1Y2_RS16965	COG0493	'glutamate synthase
AR1Y2_RS16980	COG1121	(ABC) transporter
AR1Y2_RS17015	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS17020	COG3715	PTS system
AR1Y2_RS17035	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AR1Y2_RS17035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AR1Y2_RS17040	COG0534	Mate efflux family protein
AR1Y2_RS17045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AR1Y2_RS17050	COG3716	PTS system mannose fructose sorbose family IID component
AR1Y2_RS17070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AR1Y2_RS17075	COG2222	sugar isomerase
AR1Y2_RS17080	COG2188	Transcriptional regulator
AR1Y2_RS17100	COG2184	nucleotidyltransferase activity
AR1Y2_RS17105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AR1Y2_RS17110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AR1Y2_RS17115	COG0049	tRNA binding
AR1Y2_RS17120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AR1Y2_RS17125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AR1Y2_RS17130	COG0085	RNA polymerase activity
AR1Y2_RS17135	COG0222	ribosome binding
AR1Y2_RS17155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AR1Y2_RS17160	COG1126	abc transporter atp-binding protein
AR1Y2_RS17170	COG0765	amino acid transport
AR1Y2_RS17275	COG0081	regulation of translation
AR1Y2_RS17285	COG0250	Participates in transcription elongation, termination and antitermination
AR1Y2_RS17295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AR1Y2_RS17300	COG0602	queuosine metabolic process
AR1Y2_RS17310	COG1328	CTP reductase activity
AR1Y2_RS17310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AR1Y2_RS17325	COG0697	spore germination
AR1Y2_RS17330	COG1802	Transcriptional regulator
AR1Y2_RS17335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AR1Y2_RS17345	COG4466	Protein conserved in bacteria
AR1Y2_RS17365	COG1592	Rubrerythrin
AR1Y2_RS17385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AR1Y2_RS17395	COG0756	dUTP diphosphatase activity
AR1Y2_RS17400	COG0166	Belongs to the GPI family
AR1Y2_RS17405	COG0726	polysaccharide deacetylase
AR1Y2_RS17415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AR1Y2_RS17425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AR1Y2_RS17445	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS17450	COG0673	inositol 2-dehydrogenase activity
AR1Y2_RS17455	COG1082	Xylose isomerase domain protein TIM barrel
AR1Y2_RS17460	COG0789	Transcriptional regulator
AR1Y2_RS17465	COG2207	Transcriptional regulator
AR1Y2_RS17465	COG1917	Cupin 2, conserved barrel domain protein
AR1Y2_RS17480	COG1132	(ABC) transporter
AR1Y2_RS17485	COG1132	(ABC) transporter
AR1Y2_RS17490	COG0647	UMP catabolic process
AR1Y2_RS17500	COG0371	Dehydrogenase
AR1Y2_RS17505	COG3775	system Galactitol-specific IIC component
AR1Y2_RS17520	COG3711	transcriptional antiterminator
AR1Y2_RS17520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS17525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS17525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AR1Y2_RS17525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AR1Y2_RS17530	COG1105	Belongs to the carbohydrate kinase PfkB family
AR1Y2_RS17535	COG1349	DNA-binding transcription factor activity
AR1Y2_RS17555	COG1136	(ABC) transporter
AR1Y2_RS17570	COG4251	negative regulation of phosphorylation
AR1Y2_RS17575	COG0745	RESPONSE REGULATOR receiver
AR1Y2_RS17580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AR1Y2_RS17590	COG1475	DNA binding
AR1Y2_RS17595	COG1192	Involved in chromosome partitioning
AR1Y2_RS17600	COG0018	arginyl-trna synthetase
AR1Y2_RS17615	COG0357	Ribosomal RNA small subunit methyltransferase G
AR1Y2_RS17620	COG0445	tRNA wobble uridine modification
AR1Y2_RS17625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AR1Y2_RS17630	COG1847	R3H domain protein
AR1Y2_RS17635	COG0706	membrane insertase activity
AR1Y2_RS17640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AR1Y2_RS17645	COG0594	ribonuclease P activity
AR1Y2_RS17650	COG0230	Belongs to the bacterial ribosomal protein bL34 family