locus-tag	class	description
P029_RS00005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P029_RS00005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
P029_RS00010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
P029_RS00015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
P029_RS00020	COG1127	ABC transporter
P029_RS00030	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
P029_RS00035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
P029_RS00045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P029_RS00060	COG0752	glycyl-tRNA synthetase alpha subunit
P029_RS00070	COG0484	heat shock protein binding
P029_RS00075	COG0157	Belongs to the NadC ModD family
P029_RS00080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
P029_RS00085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
P029_RS00090	COG1845	cytochrome c oxidase, subunit III
P029_RS00100	COG1253	flavin adenine dinucleotide binding
P029_RS00110	COG4695	Portal protein
P029_RS00120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
P029_RS00125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
P029_RS00150	COG0180	Tryptophanyl-tRNA synthetase
P029_RS00155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
P029_RS00160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P029_RS00160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P029_RS00165	COG0504	CTP synthase activity
P029_RS00175	COG4974	Belongs to the 'phage' integrase family
P029_RS00185	COG0281	malic enzyme
P029_RS00185	COG0280	phosphate acetyltransferase
P029_RS00195	COG0651	ATP synthesis coupled electron transport
P029_RS00205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
P029_RS00215	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
P029_RS00235	COG1840	ABC-type Fe3 transport system, periplasmic component
P029_RS00240	COG2835	tetraacyldisaccharide 4'-kinase activity
P029_RS00250	COG0228	four-way junction DNA binding
P029_RS00260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
P029_RS00270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
P029_RS00275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
P029_RS00285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
P029_RS00290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P029_RS00295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P029_RS00300	COG0484	heat shock protein binding
P029_RS00305	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
P029_RS00330	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
P029_RS00330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P029_RS00370	COG1722	exodeoxyribonuclease VII activity
P029_RS00375	COG3118	belongs to the thioredoxin family
P029_RS00385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
P029_RS00390	COG2267	carboxylic ester hydrolase activity
P029_RS00405	COG0517	IMP dehydrogenase activity
P029_RS00405	COG0516	GMP reductase activity
P029_RS00410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
P029_RS00415	COG0516	GMP reductase activity
P029_RS00415	COG0517	IMP dehydrogenase activity
P029_RS00420	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
P029_RS00430	COG4695	Portal protein
P029_RS00435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
P029_RS00440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
P029_RS00455	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
P029_RS00460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P029_RS00465	COG0612	Peptidase, M16
P029_RS00480	COG0528	UMP kinase activity
P029_RS00485	COG0307	riboflavin synthase, alpha
P029_RS00505	COG0528	UMP kinase activity
P029_RS00510	COG0233	cytoplasmic translational termination
P029_RS00515	COG4589	Belongs to the CDS family
P029_RS00545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
P029_RS00550	COG0124	histidyl-tRNA synthetase
P029_RS00560	COG1612	heme a metabolic process
P029_RS00570	COG0717	Belongs to the dCTP deaminase family
P029_RS00585	COG1278	Cold shock
P029_RS00590	COG5000	phosphorelay sensor kinase activity
P029_RS00595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
P029_RS00600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
P029_RS00630	COG0194	GDP metabolic process
P029_RS00645	COG0360	Binds together with S18 to 16S ribosomal RNA
P029_RS00650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P029_RS00655	COG0359	binds to the 23S rRNA
P029_RS00660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
P029_RS00670	COG1132	(ABC) transporter
P029_RS00705	COG2814	Major facilitator Superfamily
P029_RS00715	COG0752	glycyl-tRNA synthetase alpha subunit
P029_RS00720	COG2255	four-way junction helicase activity
P029_RS00725	COG0632	four-way junction helicase activity
P029_RS00730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
P029_RS00735	COG0194	GDP metabolic process
P029_RS00755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
P029_RS00775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
P029_RS00780	COG3474	cytochrome
P029_RS00790	COG0574	Belongs to the PEP-utilizing enzyme family
P029_RS00790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P029_RS00800	COG0546	phosphoglycolate phosphatase activity
P029_RS00815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
P029_RS00830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
P029_RS00835	COG2204	response regulator
P029_RS00840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
P029_RS00845	COG4974	Belongs to the 'phage' integrase family
P029_RS00860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
P029_RS00870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
P029_RS00895	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
P029_RS00905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
P029_RS00910	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
P029_RS00935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P029_RS00950	COG4942	peptidase
P029_RS00955	COG1494	fructose-1,6-bisphosphatase
P029_RS00960	COG0445	tRNA wobble uridine modification
P029_RS00990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
P029_RS01000	COG3485	protocatechuate 3,4-dioxygenase
P029_RS01015	COG0542	response to heat
P029_RS01035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
P029_RS01040	COG2003	Belongs to the UPF0758 family
P029_RS01045	COG0321	lipoyl(octanoyl) transferase activity
P029_RS01050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
P029_RS01055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P029_RS01060	COG0114	fumarate hydratase activity
P029_RS01080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
P029_RS01095	COG1074	ATP-dependent DNA helicase activity
P029_RS01145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
P029_RS01155	COG0776	regulation of translation
P029_RS01160	COG0616	signal peptide processing
P029_RS01165	COG0539	negative regulation of cytoplasmic translation
P029_RS01170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
P029_RS01175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
P029_RS01190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P029_RS01195	COG0051	transcription antitermination factor activity, RNA binding
P029_RS01200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
P029_RS01205	COG0088	Forms part of the polypeptide exit tunnel
P029_RS01210	COG0089	rRNA binding
P029_RS01215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
P029_RS01220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
P029_RS01225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
P029_RS01230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
P029_RS01235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
P029_RS01240	COG0255	Belongs to the universal ribosomal protein uL29 family
P029_RS01245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
P029_RS01250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
P029_RS01255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
P029_RS01260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
P029_RS01265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
P029_RS01270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
P029_RS01275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
P029_RS01280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
P029_RS01285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
P029_RS01295	COG0201	protein transport
P029_RS01300	COG0563	adenylate kinase activity
P029_RS01305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
P029_RS01310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
P029_RS01315	COG0202	RNA polymerase activity
P029_RS01320	COG0203	ribosomal protein L17
P029_RS01330	COG0658	competence protein
P029_RS01330	COG2333	competence protein COMEC
P029_RS01350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
P029_RS01360	COG0343	queuine tRNA-ribosyltransferase activity
P029_RS01365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
P029_RS01370	COG0416	fatty acid biosynthetic process
P029_RS01390	COG0590	tRNA wobble adenosine to inosine editing
P029_RS01435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P029_RS01440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
P029_RS01450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
P029_RS01485	COG2111	Na H antiporter
P029_RS01495	COG1530	ribonuclease E activity
P029_RS01515	COG1007	ATP synthesis coupled electron transport
P029_RS01520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
P029_RS01525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
P029_RS01535	COG3577	Aspartyl protease
P029_RS01560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
P029_RS01565	COG0564	pseudouridine synthase activity
P029_RS01570	COG4770	biotin carboxylase activity
P029_RS01590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P029_RS01600	COG0581	inorganic phosphate transmembrane transporter activity
P029_RS01615	COG3451	type IV secretory pathway VirB4
P029_RS01625	COG3704	protein secretion by the type IV secretion system
P029_RS01630	COG3704	protein secretion by the type IV secretion system
P029_RS01635	COG3704	protein secretion by the type IV secretion system
P029_RS01635	COG0419	ATPase involved in DNA repair
P029_RS01650	COG0756	dUTP diphosphatase activity
P029_RS01660	COG0505	Belongs to the CarA family
P029_RS01695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
P029_RS01700	COG1160	GTP binding
P029_RS01715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P029_RS01725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
P029_RS01730	COG0424	maF-like protein
P029_RS01735	COG0052	Belongs to the universal ribosomal protein uS2 family
P029_RS01740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
P029_RS01745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
P029_RS01755	COG0723	plastoquinol--plastocyanin reductase activity
P029_RS01760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
P029_RS01790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
P029_RS01800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P029_RS01805	COG0445	tRNA wobble uridine modification
P029_RS01810	COG0445	tRNA wobble uridine modification
P029_RS01815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
P029_RS01825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
P029_RS01830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
P029_RS01855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
P029_RS01870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
P029_RS01885	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
P029_RS01895	COG0713	ATP synthesis coupled electron transport
P029_RS01900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
P029_RS01910	COG1007	ATP synthesis coupled electron transport
P029_RS01915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
P029_RS01930	COG0805	protein transport
P029_RS01940	COG0195	Participates in both transcription termination and antitermination
P029_RS01940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
P029_RS01945	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
P029_RS01955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
P029_RS01960	COG1253	flavin adenine dinucleotide binding
P029_RS01970	COG1217	gtp-binding protein TYPA
P029_RS02015	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P029_RS02025	COG0629	single-stranded DNA binding
P029_RS02030	COG0629	single-stranded DNA binding
P029_RS02035	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
P029_RS02045	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P029_RS02065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
P029_RS02075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
P029_RS02080	COG0217	transcriptional regulatory protein
P029_RS02090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
P029_RS02090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
P029_RS02120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
P029_RS02135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
P029_RS02165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
P029_RS02170	COG0540	Belongs to the ATCase OTCase family
P029_RS02175	COG0101	tRNA pseudouridine synthase activity
P029_RS02180	COG0217	transcriptional regulatory protein
P029_RS02185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
P029_RS02200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
P029_RS02205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P029_RS02215	COG1758	RNA polymerase activity
P029_RS02225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P029_RS02230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P029_RS02235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P029_RS02240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
P029_RS02245	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
P029_RS02260	COG0084	hydrolase, TatD family'
P029_RS02265	COG0084	hydrolase, TatD family'
P029_RS02310	COG0706	membrane insertase activity
P029_RS02320	COG1034	ATP synthesis coupled electron transport
P029_RS02325	COG1183	phosphatidylcholine synthase activity
P029_RS02330	COG0688	phosphatidylethanolamine metabolic process
P029_RS02335	COG0543	2 iron, 2 sulfur cluster binding
P029_RS02335	COG0493	'glutamate synthase
P029_RS02345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
P029_RS02350	COG0483	inositol monophosphate 1-phosphatase activity
P029_RS02355	COG0564	pseudouridine synthase activity
P029_RS02375	COG3932	Exopolysaccharide synthesis, ExoD
P029_RS02380	COG0215	cysteine-tRNA ligase activity
P029_RS02390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P029_RS02400	COG0018	arginyl-trna synthetase
P029_RS02430	COG0358	DNA primase activity
P029_RS02435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
P029_RS02440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
P029_RS02445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
P029_RS02450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
P029_RS02460	COG1324	tolerance protein
P029_RS02485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
P029_RS02495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P029_RS02520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
P029_RS02520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
P029_RS02525	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
P029_RS02540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
P029_RS02545	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
P029_RS02555	COG1214	PFAM Peptidase M22, glycoprotease
P029_RS02595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
P029_RS02605	COG0149	triose-phosphate isomerase activity
P029_RS02610	COG2358	TRAP transporter, solute receptor (TAXI family
P029_RS02615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
P029_RS02630	COG0039	L-malate dehydrogenase activity
P029_RS02685	COG0698	ribose 5-phosphate isomerase
P029_RS02705	COG0736	holo-[acyl-carrier-protein] synthase activity
P029_RS02710	COG0442	prolyl-tRNA aminoacylation
P029_RS02725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
P029_RS02730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
P029_RS02740	COG0492	ferredoxin-NADP+ reductase activity
P029_RS02745	COG0450	alkyl hydroperoxide reductase
P029_RS02750	COG0436	Aminotransferase
P029_RS02780	COG0506	proline dehydrogenase activity
P029_RS02780	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
P029_RS02780	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
P029_RS02785	COG2945	thiolester hydrolase activity
P029_RS02795	COG1104	cysteine desulfurase activity
P029_RS02800	COG0822	iron-sulfur transferase activity
P029_RS02805	COG0316	Belongs to the HesB IscA family
P029_RS02815	COG0443	Heat shock 70 kDa protein
P029_RS02855	COG0275	rRNA processing
P029_RS02870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
P029_RS02875	COG0148	phosphopyruvate hydratase activity
P029_RS02880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
P029_RS02885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
P029_RS02895	COG0018	arginyl-trna synthetase
P029_RS02915	COG0312	modulator of DNA gyrase
P029_RS02920	COG0302	gtp cyclohydrolase
P029_RS02925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
P029_RS02945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
P029_RS02950	COG1034	ATP synthesis coupled electron transport
P029_RS02960	COG0187	DNA topoisomerase II activity
P029_RS03005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P029_RS03010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
P029_RS03015	COG0649	NAD binding
P029_RS03020	COG0492	ferredoxin-NADP+ reductase activity
P029_RS03025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
P029_RS03030	COG1381	Involved in DNA repair and RecF pathway recombination
P029_RS03065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
P029_RS03070	COG0181	hydroxymethylbilane synthase activity
P029_RS03075	COG0285	dihydrofolate synthase activity
P029_RS03080	COG0154	amidase activity
P029_RS03100	COG0606	chelatase, subunit chli
P029_RS03135	COG0481	GTPase activity
P029_RS03140	COG2226	methyltransferase
P029_RS03145	COG1185	polyribonucleotide nucleotidyltransferase activity
P029_RS03150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
P029_RS03155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
P029_RS03205	COG0009	L-threonylcarbamoyladenylate synthase
P029_RS03210	COG0470	DNA polymerase III
P029_RS03220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
P029_RS03225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
P029_RS03245	COG1385	rRNA (uridine-N3-)-methyltransferase activity
P029_RS03250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P029_RS03265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P029_RS03270	COG0681	Belongs to the peptidase S26 family
P029_RS03320	COG0302	gtp cyclohydrolase
P029_RS03420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
P029_RS03420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
P029_RS03465	COG0113	porphobilinogen synthase activity
P029_RS03470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
P029_RS03470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
P029_RS03480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
P029_RS03500	COG0567	Dehydrogenase, E1 component
P029_RS03510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
P029_RS03530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
P029_RS03530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
P029_RS03545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
P029_RS03570	COG0322	excinuclease ABC activity
P029_RS03585	COG0326	Molecular chaperone. Has ATPase activity
P029_RS03605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
P029_RS03625	COG0210	DNA helicase
P029_RS03650	COG0482	sulfurtransferase activity
P029_RS03660	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
P029_RS03705	COG3842	ATPase activity
P029_RS03720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
P029_RS03730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
P029_RS03745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
P029_RS03750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P029_RS03755	COG0758	DNA mediated transformation
P029_RS03760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
P029_RS03785	COG2202	Pas domain
P029_RS03785	COG2205	protein histidine kinase activity
P029_RS03790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
P029_RS03810	COG1674	ftsk spoiiie
P029_RS03820	COG4536	flavin adenine dinucleotide binding
P029_RS03825	COG0352	thiamine-phosphate diphosphorylase activity
P029_RS03830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
P029_RS03835	COG1054	Belongs to the UPF0176 family
P029_RS03850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
P029_RS03860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
P029_RS03865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
P029_RS03870	COG0740	serine-type endopeptidase activity
P029_RS03875	COG0544	peptidyl-prolyl cis-trans isomerase activity
P029_RS03915	COG0156	8-amino-7-oxononanoate synthase activity
P029_RS03940	COG1121	(ABC) transporter
P029_RS03945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
P029_RS03955	COG3842	ATPase activity
P029_RS03960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
P029_RS03965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
P029_RS03970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
P029_RS03995	COG0351	phosphomethylpyrimidine kinase
P029_RS03995	COG0352	thiamine-phosphate diphosphorylase activity
P029_RS04005	COG0628	permease
P029_RS04020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
P029_RS04025	COG2009	succinate dehydrogenase
P029_RS04035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
P029_RS04050	COG0259	pyridoxamine-phosphate oxidase activity
P029_RS04055	COG0400	carboxylic ester hydrolase activity
P029_RS04060	COG0242	peptide deformylase activity
P029_RS04065	COG0167	dihydroorotate dehydrogenase activity
P029_RS04070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
P029_RS04080	COG0156	8-amino-7-oxononanoate synthase activity
P029_RS04125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
P029_RS04130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
P029_RS04135	COG0085	RNA polymerase activity
P029_RS04140	COG0222	ribosome binding
P029_RS04145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
P029_RS04150	COG0081	regulation of translation
P029_RS04155	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
P029_RS04160	COG0250	Participates in transcription elongation, termination and antitermination
P029_RS04175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
P029_RS04180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
P029_RS04185	COG0049	tRNA binding
P029_RS04190	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
P029_RS04220	COG1178	ABC-type Fe3 transport system permease component
P029_RS04235	COG1999	signal sequence binding
P029_RS04245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
P029_RS04250	COG0045	succinate-CoA ligase (ADP-forming) activity
P029_RS04255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
P029_RS04265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P029_RS04270	COG0573	inorganic phosphate transmembrane transporter activity
P029_RS04310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P029_RS04315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
P029_RS04320	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
P029_RS04325	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
P029_RS04330	COG2226	methyltransferase
P029_RS04340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
P029_RS04360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P029_RS04365	COG0109	protoheme IX farnesyltransferase activity
P029_RS04370	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P029_RS04380	COG1862	Preprotein translocase
P029_RS04400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P029_RS04410	COG0592	DNA-directed DNA polymerase activity
P029_RS04420	COG0745	RESPONSE REGULATOR receiver
P029_RS04430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P029_RS04450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P029_RS04455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
P029_RS04465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P029_RS04470	COG0489	protein tyrosine kinase activity
P029_RS04480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
P029_RS04525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
P029_RS04650	COG0330	HflC and HflK could
P029_RS04655	COG0330	HflC and HflK could
P029_RS04660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P029_RS04665	COG0571	ribonuclease III activity
P029_RS04670	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
P029_RS04705	COG3346	SURF1 family
P029_RS04715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P029_RS04720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
P029_RS04725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
P029_RS04745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
P029_RS04745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
P029_RS04750	COG0473	3-isopropylmalate dehydrogenase activity
P029_RS04775	COG0612	Peptidase, M16
P029_RS04780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
P029_RS04785	COG0196	riboflavin kinase activity
P029_RS04790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
P029_RS04805	COG0653	protein targeting
P029_RS04810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
P029_RS04825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
P029_RS04860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P029_RS04865	COG0356	it plays a direct role in the translocation of protons across the membrane
P029_RS04895	COG0508	dehydrogenase complex catalyzes the overall conversion of
P029_RS04900	COG0024	Methionine aminopeptidase
P029_RS04905	COG2890	protein-(glutamine-N5) methyltransferase activity
P029_RS04920	COG1138	Cytochrome C-type biogenesis protein
P029_RS04925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P029_RS04930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
P029_RS04935	COG0138	bifunctional purine biosynthesis protein purh
P029_RS04940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P029_RS04950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P029_RS04955	COG0750	zinc metalloprotease
P029_RS04970	COG1686	Belongs to the peptidase S11 family
P029_RS04985	COG0617	tRNA 3'-terminal CCA addition
P029_RS04990	COG0105	UTP biosynthetic process
P029_RS04995	COG1396	sequence-specific DNA binding
P029_RS05020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
P029_RS05040	COG1830	Aldolase
P029_RS05045	COG0508	dehydrogenase complex catalyzes the overall conversion of
P029_RS05060	COG0156	8-amino-7-oxononanoate synthase activity
P029_RS05065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
P029_RS05075	COG0174	glutamine synthetase
P029_RS05080	COG0142	geranyltranstransferase activity
P029_RS05105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
P029_RS05110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
P029_RS05135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P029_RS05140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
P029_RS05150	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
P029_RS05155	COG0193	aminoacyl-tRNA hydrolase activity
P029_RS05160	COG0193	aminoacyl-tRNA hydrolase activity
P029_RS05165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
P029_RS05170	COG1040	competence protein
P029_RS05185	COG1981	membrane
P029_RS05190	COG0022	dehydrogenase e1 component
P029_RS05200	COG0312	modulator of DNA gyrase
P029_RS05210	COG0012	GTP binding
P029_RS05250	COG1138	Cytochrome C-type biogenesis protein
P029_RS05270	COG0372	Belongs to the citrate synthase family
P029_RS05275	COG0519	Catalyzes the synthesis of GMP from XMP
P029_RS05290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
P029_RS05295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
P029_RS05295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
P029_RS05305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
P029_RS05315	COG0776	regulation of translation
P029_RS05345	COG0552	protein localization to endoplasmic reticulum
P029_RS05350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
P029_RS05375	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
P029_RS05380	COG0336	Belongs to the RNA methyltransferase TrmD family
P029_RS05390	COG1058	Belongs to the CinA family
P029_RS05390	COG1546	Belongs to the CinA family
P029_RS05400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
P029_RS05425	COG0500	methyltransferase
P029_RS05450	COG1570	exodeoxyribonuclease VII activity
P029_RS05490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
P029_RS05495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
P029_RS05495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
P029_RS05500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
P029_RS05505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
P029_RS05510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
P029_RS05530	COG4591	ABC-type transport system involved in lipoprotein release permease component
P029_RS05540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P029_RS05550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
P029_RS05560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P029_RS05565	COG0670	Belongs to the BI1 family
P029_RS05570	COG0802	atpase or kinase
P029_RS05585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
P029_RS05620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
P029_RS05635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P029_RS05640	COG0556	nucleotide-excision repair
P029_RS05665	COG0242	peptide deformylase activity
P029_RS05670	COG0204	Acyl-transferase
P029_RS05675	COG0268	Binds directly to 16S ribosomal RNA
P029_RS05680	COG0242	peptide deformylase activity
P029_RS05690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
P029_RS05695	COG0728	peptidoglycan biosynthetic process
P029_RS05770	COG1230	cation diffusion facilitator family transporter
P029_RS05800	COG3505	Type IV secretory pathway VirD4
P029_RS05805	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
P029_RS05810	COG2948	multi-organism process
P029_RS05830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP