locus-tag	class	description
G3A50_RS00005	COG1461	Dihydroxyacetone kinase
G3A50_RS00015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3A50_RS00030	COG2376	Dihydroxyacetone kinase
G3A50_RS00035	COG0028	Belongs to the TPP enzyme family
G3A50_RS00040	COG0492	ferredoxin-NADP+ reductase activity
G3A50_RS00060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3A50_RS00085	COG1129	ABC transporter
G3A50_RS00090	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS00095	COG1879	ABC-type sugar transport system periplasmic component
G3A50_RS00100	COG0693	protein deglycase activity
G3A50_RS00125	COG0300	oxidoreductase activity
G3A50_RS00150	COG0363	glucosamine-6-phosphate deaminase activity
G3A50_RS00170	COG4208	sulfate ABC transporter
G3A50_RS00180	COG2721	sulfolactate sulfo-lyase activity
G3A50_RS00190	COG0625	glutathione transferase activity
G3A50_RS00210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G3A50_RS00230	COG0154	amidase activity
G3A50_RS00255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G3A50_RS00260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G3A50_RS00275	COG0540	Belongs to the ATCase OTCase family
G3A50_RS00280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G3A50_RS00285	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G3A50_RS00290	COG0758	DNA mediated transformation
G3A50_RS00295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G3A50_RS00300	COG0477	Major facilitator Superfamily
G3A50_RS00305	COG0557	exoribonuclease II activity
G3A50_RS00325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G3A50_RS00330	COG0784	Response regulator, receiver
G3A50_RS00340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G3A50_RS00385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G3A50_RS00395	COG1686	Belongs to the peptidase S11 family
G3A50_RS00410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G3A50_RS00445	COG3300	MHYT domain
G3A50_RS00445	COG5001	Diguanylate cyclase
G3A50_RS00450	COG2239	Acts as a magnesium transporter
G3A50_RS00455	COG1254	Belongs to the acylphosphatase family
G3A50_RS00460	COG0321	lipoyl(octanoyl) transferase activity
G3A50_RS00485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G3A50_RS00490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G3A50_RS00495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3A50_RS00500	COG0203	ribosomal protein L17
G3A50_RS00505	COG0202	RNA polymerase activity
G3A50_RS00510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G3A50_RS00515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G3A50_RS00520	COG0563	adenylate kinase activity
G3A50_RS00525	COG0201	protein transport
G3A50_RS00530	COG0200	Binds to the 23S rRNA
G3A50_RS00535	COG1841	ribosomal large subunit assembly
G3A50_RS00540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G3A50_RS00545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G3A50_RS00550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G3A50_RS00555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G3A50_RS00560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G3A50_RS00565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G3A50_RS00570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G3A50_RS00575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G3A50_RS00580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G3A50_RS00585	COG0255	Belongs to the universal ribosomal protein uL29 family
G3A50_RS00590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G3A50_RS00595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G3A50_RS00600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G3A50_RS00605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G3A50_RS00610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G3A50_RS00615	COG0089	rRNA binding
G3A50_RS00620	COG0088	Forms part of the polypeptide exit tunnel
G3A50_RS00625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G3A50_RS00630	COG0051	transcription antitermination factor activity, RNA binding
G3A50_RS00635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3A50_RS00640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G3A50_RS00645	COG0049	tRNA binding
G3A50_RS00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G3A50_RS00665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G3A50_RS00670	COG0085	RNA polymerase activity
G3A50_RS00675	COG0222	ribosome binding
G3A50_RS00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G3A50_RS00685	COG0081	regulation of translation
G3A50_RS00690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G3A50_RS00700	COG0693	protein deglycase activity
G3A50_RS00710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G3A50_RS00730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3A50_RS00745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G3A50_RS00755	COG0251	oxidation-reduction process
G3A50_RS00775	COG3706	GGDEF domain
G3A50_RS00790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3A50_RS00795	COG1253	flavin adenine dinucleotide binding
G3A50_RS00805	COG3842	ATPase activity
G3A50_RS00815	COG1177	transmembrane transport
G3A50_RS00825	COG1234	tRNA 3'-trailer cleavage
G3A50_RS00835	COG1324	tolerance protein
G3A50_RS00840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G3A50_RS00860	COG0778	Nitroreductase
G3A50_RS00865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3A50_RS00870	COG1388	LysM domain
G3A50_RS00870	COG1376	ErfK ybiS ycfS ynhG family protein
G3A50_RS00885	COG0729	surface antigen
G3A50_RS00895	COG0300	oxidoreductase activity
G3A50_RS00900	COG0415	Belongs to the DNA photolyase family
G3A50_RS00905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G3A50_RS00910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G3A50_RS00915	COG2897	thiosulfate sulfurtransferase activity
G3A50_RS00920	COG1126	abc transporter atp-binding protein
G3A50_RS00925	COG0765	amino acid transport
G3A50_RS00930	COG4597	amino acid ABC transporter
G3A50_RS00935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS00940	COG0626	cystathionine gamma-synthase activity
G3A50_RS00955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G3A50_RS00960	COG0830	nickel cation binding
G3A50_RS00965	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G3A50_RS00970	COG0804	urea catabolic process
G3A50_RS00975	COG0831	urea catabolic process
G3A50_RS00975	COG0832	Belongs to the urease beta subunit family
G3A50_RS00980	COG0829	nickel cation binding
G3A50_RS00985	COG3842	ATPase activity
G3A50_RS01060	COG2132	Multicopper oxidase
G3A50_RS01065	COG3487	Iron-regulated protein
G3A50_RS01090	COG0697	spore germination
G3A50_RS01105	COG1494	fructose-1,6-bisphosphatase
G3A50_RS01115	COG0436	Aminotransferase
G3A50_RS01125	COG3243	poly(R)-hydroxyalkanoic acid synthase
G3A50_RS01135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G3A50_RS01145	COG0187	DNA topoisomerase II activity
G3A50_RS01150	COG1280	lysine exporter protein (LysE YggA)
G3A50_RS01160	COG0513	Belongs to the DEAD box helicase family
G3A50_RS01170	COG0316	Belongs to the HesB IscA family
G3A50_RS01175	COG0346	lactoylglutathione lyase activity
G3A50_RS01180	COG2151	metal-sulfur cluster biosynthetic enzyme
G3A50_RS01185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G3A50_RS01190	COG0719	Fe-S assembly protein
G3A50_RS01195	COG0396	ATPase activity
G3A50_RS01200	COG0719	Fe-S assembly protein
G3A50_RS01205	COG1104	cysteine desulfurase activity
G3A50_RS01210	COG2945	thiolester hydrolase activity
G3A50_RS01220	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G3A50_RS01225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G3A50_RS01235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3A50_RS01255	COG0860	N-Acetylmuramoyl-L-alanine amidase
G3A50_RS01260	COG1530	ribonuclease E activity
G3A50_RS01265	COG0436	Aminotransferase
G3A50_RS01280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G3A50_RS01285	COG0511	ligase activity, forming carbon-carbon bonds
G3A50_RS01290	COG0439	Biotin carboxylase
G3A50_RS01310	COG2814	Major facilitator Superfamily
G3A50_RS01315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3A50_RS01325	COG1278	Cold shock
G3A50_RS01330	COG1278	Cold shock
G3A50_RS01340	COG0281	malic enzyme
G3A50_RS01340	COG0280	phosphate acetyltransferase
G3A50_RS01350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G3A50_RS01360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G3A50_RS01365	COG0248	Ppx GppA phosphatase
G3A50_RS01370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G3A50_RS01380	COG0628	permease
G3A50_RS01385	COG3135	benzoate transporter
G3A50_RS01390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G3A50_RS01395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G3A50_RS01405	COG0243	molybdopterin cofactor binding
G3A50_RS01410	COG0861	Integral membrane protein TerC family
G3A50_RS01415	COG0861	Integral membrane protein TerC family
G3A50_RS01420	COG0105	UTP biosynthetic process
G3A50_RS01435	COG2318	DinB family
G3A50_RS01440	COG0488	(ABC) transporter
G3A50_RS01445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G3A50_RS01455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3A50_RS01470	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G3A50_RS01480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G3A50_RS01485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3A50_RS01490	COG0194	GDP metabolic process
G3A50_RS01495	COG1561	YicC-like family, N-terminal region
G3A50_RS01500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G3A50_RS01505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3A50_RS01510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3A50_RS01520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G3A50_RS01525	COG3706	GGDEF domain
G3A50_RS01530	COG0360	Binds together with S18 to 16S ribosomal RNA
G3A50_RS01535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G3A50_RS01545	COG0359	binds to the 23S rRNA
G3A50_RS01550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3A50_RS01555	COG0305	Participates in initiation and elongation during chromosome replication
G3A50_RS01560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G3A50_RS01575	COG1286	toxin biosynthetic process
G3A50_RS01580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G3A50_RS01585	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS01590	COG1160	GTP binding
G3A50_RS01600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G3A50_RS01615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G3A50_RS01620	COG1393	Belongs to the ArsC family
G3A50_RS01675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G3A50_RS01680	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G3A50_RS01685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3A50_RS01690	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G3A50_RS01695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G3A50_RS01700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G3A50_RS01705	COG1984	allophanate hydrolase subunit 2
G3A50_RS01710	COG2188	Transcriptional regulator
G3A50_RS01715	COG0402	S-adenosylhomocysteine deaminase activity
G3A50_RS01745	COG0384	phenazine biosynthesis protein PhzF
G3A50_RS01750	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G3A50_RS01755	COG0154	amidase activity
G3A50_RS01760	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3A50_RS01780	COG2226	methyltransferase
G3A50_RS01785	COG1720	tRNA m6t6A37 methyltransferase activity
G3A50_RS01790	COG1376	ErfK ybiS ycfS ynhG family protein
G3A50_RS01820	COG4122	O-methyltransferase activity
G3A50_RS01830	COG2890	protein-(glutamine-N5) methyltransferase activity
G3A50_RS01850	COG4106	trans-aconitate 2-methyltransferase activity
G3A50_RS01855	COG0488	(ABC) transporter
G3A50_RS01860	COG1877	trehalose-phosphatase activity
G3A50_RS01870	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G3A50_RS01875	COG3447	MASE1 domain protein
G3A50_RS01875	COG5002	protein histidine kinase activity
G3A50_RS01875	COG5001	Diguanylate cyclase
G3A50_RS01890	COG5487	UPF0391 membrane protein
G3A50_RS01900	COG1280	lysine exporter protein (LysE YggA)
G3A50_RS01910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G3A50_RS01915	COG0358	DNA primase activity
G3A50_RS01920	COG1610	YqeY-like protein
G3A50_RS01925	COG0505	Belongs to the CarA family
G3A50_RS01930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G3A50_RS01935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3A50_RS01940	COG0438	transferase activity, transferring glycosyl groups
G3A50_RS01955	COG1442	glycosyl transferase family 8
G3A50_RS01960	COG1522	sequence-specific DNA binding
G3A50_RS01965	COG0492	ferredoxin-NADP+ reductase activity
G3A50_RS01970	COG0583	DNA-binding transcription factor activity
G3A50_RS01980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3A50_RS01990	COG0436	Aminotransferase
G3A50_RS01995	COG0625	glutathione transferase activity
G3A50_RS02005	COG2133	pyrroloquinoline quinone binding
G3A50_RS02015	COG3128	pkhd-type hydroxylase
G3A50_RS02045	COG2968	Membrane
G3A50_RS02225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3A50_RS02255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3A50_RS02340	COG0582	viral genome integration into host DNA
G3A50_RS02480	COG3842	ATPase activity
G3A50_RS02490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3A50_RS02505	COG0583	DNA-binding transcription factor activity
G3A50_RS02515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3A50_RS02520	COG0463	Glycosyl transferase, family 2
G3A50_RS02530	COG0500	methyltransferase
G3A50_RS02545	COG1132	(ABC) transporter
G3A50_RS02600	COG1012	belongs to the aldehyde dehydrogenase family
G3A50_RS02605	COG3284	Transcriptional regulator
G3A50_RS02615	COG1320	monovalent cation:proton antiporter activity
G3A50_RS02620	COG2212	antiporter activity
G3A50_RS02625	COG1863	multisubunit Na H antiporter MnhE subunit
G3A50_RS02630	COG0651	ATP synthesis coupled electron transport
G3A50_RS02635	COG1006	Multisubunit Na H antiporter MnhC subunit
G3A50_RS02640	COG2111	Na H antiporter
G3A50_RS02640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3A50_RS02660	COG2198	Histidine kinase
G3A50_RS02660	COG0784	Response regulator, receiver
G3A50_RS02660	COG2205	protein histidine kinase activity
G3A50_RS02700	COG0405	Gamma-glutamyltransferase
G3A50_RS02705	COG1671	Belongs to the UPF0178 family
G3A50_RS02715	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G3A50_RS02740	COG0556	nucleotide-excision repair
G3A50_RS02780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G3A50_RS02785	COG1278	Cold shock
G3A50_RS02795	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3A50_RS02805	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3A50_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS02825	COG0322	excinuclease ABC activity
G3A50_RS02830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G3A50_RS02835	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G3A50_RS02840	COG0314	molybdopterin synthase activity
G3A50_RS02850	COG1846	Transcriptional regulator
G3A50_RS02855	COG0745	RESPONSE REGULATOR receiver
G3A50_RS02870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3A50_RS02895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G3A50_RS02920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G3A50_RS02930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G3A50_RS02935	COG0193	aminoacyl-tRNA hydrolase activity
G3A50_RS02940	COG0012	GTP binding
G3A50_RS02960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G3A50_RS02960	COG2857	Cytochrome c1
G3A50_RS02965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G3A50_RS02965	COG2857	Cytochrome c1
G3A50_RS02970	COG0723	plastoquinol--plastocyanin reductase activity
G3A50_RS02975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G3A50_RS02980	COG0408	coproporphyrinogen oxidase activity
G3A50_RS02985	COG1132	(ABC) transporter
G3A50_RS02990	COG0617	tRNA 3'-terminal CCA addition
G3A50_RS03000	COG0494	nUDIX hydrolase
G3A50_RS03010	COG0714	Associated with various cellular activities
G3A50_RS03060	COG0435	Glutathione S-transferase
G3A50_RS03075	COG2226	methyltransferase
G3A50_RS03080	COG0482	sulfurtransferase activity
G3A50_RS03090	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G3A50_RS03095	COG3454	Phosphonate metabolism
G3A50_RS03100	COG4778	phosphonate C-P lyase system protein PhnL
G3A50_RS03105	COG4107	phosphonate C-P lyase system protein PhnK
G3A50_RS03115	COG3627	carbon phosphorus lyase activity
G3A50_RS03120	COG3626	phosphonate metabolism
G3A50_RS03125	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
G3A50_RS03130	COG3624	Phosphonate C-P lyase system protein PhnG
G3A50_RS03135	COG2188	Transcriptional regulator
G3A50_RS03145	COG1304	FMN binding
G3A50_RS03170	COG1278	Cold shock
G3A50_RS03200	COG0590	tRNA wobble adenosine to inosine editing
G3A50_RS03215	COG0463	Glycosyl transferase, family 2
G3A50_RS03220	COG0671	phosphoesterase, PA-phosphatase related
G3A50_RS03225	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3A50_RS03225	COG3952	Lipid A Biosynthesis
G3A50_RS03230	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G3A50_RS03240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3A50_RS03250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3A50_RS03255	COG0247	lactate metabolic process
G3A50_RS03255	COG0277	FAD linked oxidase domain protein
G3A50_RS03260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G3A50_RS03265	COG1802	Transcriptional regulator
G3A50_RS03270	COG1802	Transcriptional regulator
G3A50_RS03275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3A50_RS03280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G3A50_RS03285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS03295	COG2115	Belongs to the xylose isomerase family
G3A50_RS03300	COG1070	Carbohydrate kinase
G3A50_RS03305	COG1609	Transcriptional regulator
G3A50_RS03310	COG4213	ABC transporter substrate-binding protein
G3A50_RS03315	COG4214	carbohydrate transport
G3A50_RS03330	COG2847	Copper chaperone PCu(A)C
G3A50_RS03345	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
G3A50_RS03345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3A50_RS03360	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G3A50_RS03400	COG0546	phosphoglycolate phosphatase activity
G3A50_RS03410	COG1376	ErfK ybiS ycfS ynhG family protein
G3A50_RS03425	COG2814	Major facilitator Superfamily
G3A50_RS03435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3A50_RS03440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3A50_RS03450	COG0489	protein tyrosine kinase activity
G3A50_RS03455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS03480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G3A50_RS03485	COG0778	Nitroreductase
G3A50_RS03490	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G3A50_RS03505	COG0730	response to heat
G3A50_RS03510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G3A50_RS03520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3A50_RS03530	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G3A50_RS03540	COG1959	2 iron, 2 sulfur cluster binding
G3A50_RS03550	COG2011	ABC-type metal ion transport system permease component
G3A50_RS03555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G3A50_RS03570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS03575	COG0765	amino acid transport
G3A50_RS03580	COG1126	abc transporter atp-binding protein
G3A50_RS03605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3A50_RS03615	COG1178	ABC-type Fe3 transport system permease component
G3A50_RS03620	COG1053	succinate dehydrogenase
G3A50_RS03625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3A50_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS03645	COG1045	serine acetyltransferase
G3A50_RS03665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS03670	COG1116	anion transmembrane transporter activity
G3A50_RS03675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS03680	COG0431	NADPH-dependent FMN reductase
G3A50_RS03690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS03695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS03695	COG1116	anion transmembrane transporter activity
G3A50_RS03700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3A50_RS03710	COG4521	taurine ABC transporter
G3A50_RS03720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS03735	COG1116	anion transmembrane transporter activity
G3A50_RS03740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS03745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3A50_RS03775	COG4691	Plasmid stability protein
G3A50_RS03780	COG1487	ribonuclease activity
G3A50_RS03790	COG5489	Protein of unknown function (DUF736)
G3A50_RS03820	COG1192	Involved in chromosome partitioning
G3A50_RS03840	COG0741	lytic transglycosylase activity
G3A50_RS03875	COG3621	Patatin-like phospholipase
G3A50_RS03905	COG4962	Type ii secretion system protein e
G3A50_RS03920	COG3451	type IV secretory pathway VirB4
G3A50_RS03935	COG3846	protein secretion by the type IV secretion system
G3A50_RS03940	COG3701	Conjugal transfer protein
G3A50_RS03960	COG0583	DNA-binding transcription factor activity
G3A50_RS04010	COG1137	ATPase activity
G3A50_RS04015	COG1802	Transcriptional regulator
G3A50_RS04040	COG3181	Tripartite tricarboxylate transporter family receptor
G3A50_RS04070	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
G3A50_RS04095	COG4953	penicillin-binding protein 1C
G3A50_RS04105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3A50_RS04110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3A50_RS04115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3A50_RS04120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3A50_RS04150	COG0174	glutamine synthetase
G3A50_RS04160	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G3A50_RS04185	COG4221	oxidoreductase activity
G3A50_RS04200	COG1183	phosphatidylcholine synthase activity
G3A50_RS04205	COG0688	phosphatidylethanolamine metabolic process
G3A50_RS04210	COG5265	(ABC) transporter
G3A50_RS04220	COG1611	Belongs to the LOG family
G3A50_RS04230	COG0215	cysteine-tRNA ligase activity
G3A50_RS04240	COG3045	CreA protein
G3A50_RS04255	COG4149	molybdate abc transporter
G3A50_RS04260	COG0725	ABC transporter, periplasmic molybdate-binding protein
G3A50_RS04270	COG1523	belongs to the glycosyl hydrolase 13 family
G3A50_RS04275	COG0297	glycogen (starch) synthase activity
G3A50_RS04285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3A50_RS04290	COG0058	SHG alpha-glucan phosphorylase activity
G3A50_RS04300	COG1797	cobyrinic acid a,c-diamide synthase activity
G3A50_RS04380	COG1492	cobalamin metabolic process
G3A50_RS04390	COG0514	ATP-dependent DNA helicase (RecQ)
G3A50_RS04405	COG0500	methyltransferase
G3A50_RS04410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G3A50_RS04475	COG2022	thiamine diphosphate biosynthetic process
G3A50_RS04490	COG4191	Histidine kinase
G3A50_RS04490	COG0784	Response regulator, receiver
G3A50_RS04495	COG0671	phosphoesterase, PA-phosphatase related
G3A50_RS04515	COG2814	Major facilitator Superfamily
G3A50_RS04540	COG2111	Na H antiporter
G3A50_RS04540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3A50_RS04545	COG1006	Multisubunit Na H antiporter MnhC subunit
G3A50_RS04550	COG0651	ATP synthesis coupled electron transport
G3A50_RS04560	COG2212	antiporter activity
G3A50_RS04565	COG1320	monovalent cation:proton antiporter activity
G3A50_RS04585	COG1126	abc transporter atp-binding protein
G3A50_RS04590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS04600	COG4948	Mandelate Racemase Muconate Lactonizing
G3A50_RS04615	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS04640	COG0625	glutathione transferase activity
G3A50_RS04685	COG4948	Mandelate Racemase Muconate Lactonizing
G3A50_RS04690	COG1177	transmembrane transport
G3A50_RS04695	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3A50_RS04700	COG3842	ATPase activity
G3A50_RS04705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3A50_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS04720	COG2186	Transcriptional regulator
G3A50_RS04725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G3A50_RS04730	COG0765	amino acid transport
G3A50_RS04735	COG4948	Mandelate Racemase Muconate Lactonizing
G3A50_RS04740	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3A50_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS04765	COG2814	Major facilitator Superfamily
G3A50_RS04790	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3A50_RS04795	COG1177	transmembrane transport
G3A50_RS04800	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G3A50_RS04830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3A50_RS04835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3A50_RS04845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3A50_RS04875	COG1802	Transcriptional regulator
G3A50_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS04915	COG0395	ABC-type sugar transport system, permease component
G3A50_RS04920	COG1175	transmembrane transport
G3A50_RS04930	COG3842	ATPase activity
G3A50_RS04940	COG0277	FAD linked oxidase domain protein
G3A50_RS04945	COG1609	Transcriptional regulator
G3A50_RS04985	COG1522	sequence-specific DNA binding
G3A50_RS04990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G3A50_RS05015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3A50_RS05020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS05030	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G3A50_RS05050	COG0583	DNA-binding transcription factor activity
G3A50_RS05095	COG0745	RESPONSE REGULATOR receiver
G3A50_RS05105	COG0745	RESPONSE REGULATOR receiver
G3A50_RS05110	COG2205	protein histidine kinase activity
G3A50_RS05115	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G3A50_RS05120	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G3A50_RS05125	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G3A50_RS05140	COG4191	Histidine kinase
G3A50_RS05145	COG2267	carboxylic ester hydrolase activity
G3A50_RS05150	COG0583	DNA-binding transcription factor activity
G3A50_RS05160	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS05175	COG0671	phosphoesterase, PA-phosphatase related
G3A50_RS05185	COG2124	cytochrome p450
G3A50_RS05240	COG0564	pseudouridine synthase activity
G3A50_RS05245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G3A50_RS05275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G3A50_RS05300	COG5001	Diguanylate cyclase
G3A50_RS05300	COG3300	MHYT domain
G3A50_RS05320	COG0483	inositol monophosphate 1-phosphatase activity
G3A50_RS05335	COG0071	Belongs to the small heat shock protein (HSP20) family
G3A50_RS05345	COG0069	glutamate synthase activity
G3A50_RS05345	COG0067	glutamate synthase
G3A50_RS05345	COG0070	glutamate synthase
G3A50_RS05375	COG2951	lytic endotransglycosylase activity
G3A50_RS05380	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G3A50_RS05385	COG0542	response to heat
G3A50_RS05390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3A50_RS05395	COG0527	aspartate kinase activity
G3A50_RS05405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G3A50_RS05410	COG2890	protein-(glutamine-N5) methyltransferase activity
G3A50_RS05440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3A50_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS05460	COG0183	Belongs to the thiolase family
G3A50_RS05465	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
G3A50_RS05470	COG3300	MHYT domain
G3A50_RS05470	COG5001	Diguanylate cyclase
G3A50_RS05480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G3A50_RS05485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3A50_RS05490	COG0142	geranyltranstransferase activity
G3A50_RS05500	COG0473	3-isopropylmalate dehydrogenase activity
G3A50_RS05535	COG3038	cytochrome b561
G3A50_RS05545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G3A50_RS05560	COG0335	large ribosomal subunit rRNA binding
G3A50_RS05565	COG0336	Belongs to the RNA methyltransferase TrmD family
G3A50_RS05575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G3A50_RS05580	COG0228	four-way junction DNA binding
G3A50_RS05585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G3A50_RS05600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G3A50_RS05610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3A50_RS05625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G3A50_RS05630	COG1040	competence protein
G3A50_RS05635	COG2226	methyltransferase
G3A50_RS05640	COG0494	nUDIX hydrolase
G3A50_RS05645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G3A50_RS05650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3A50_RS05655	COG0653	protein targeting
G3A50_RS05660	COG3034	peptidoglycan biosynthetic process
G3A50_RS05665	COG0825	malonyl-CoA metabolic process
G3A50_RS05670	COG4974	Belongs to the 'phage' integrase family
G3A50_RS05675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G3A50_RS05680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G3A50_RS05685	COG4536	flavin adenine dinucleotide binding
G3A50_RS05690	COG0271	Belongs to the BolA IbaG family
G3A50_RS05725	COG0181	hydroxymethylbilane synthase activity
G3A50_RS05730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G3A50_RS05735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G3A50_RS05745	COG2264	protein methyltransferase activity
G3A50_RS05750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3A50_RS05755	COG2902	Dehydrogenase
G3A50_RS05760	COG3047	cAMP biosynthetic process
G3A50_RS05765	COG0138	bifunctional purine biosynthesis protein purh
G3A50_RS05775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G3A50_RS05775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3A50_RS05780	COG0837	glucose binding
G3A50_RS05785	COG0564	pseudouridine synthase activity
G3A50_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS05805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G3A50_RS05810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G3A50_RS05820	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
G3A50_RS05825	COG4689	acetoacetate decarboxylase
G3A50_RS05835	COG0523	cobalamin synthesis protein
G3A50_RS05840	COG0803	Belongs to the bacterial solute-binding protein 9 family
G3A50_RS05860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G3A50_RS05870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3A50_RS05895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS05900	COG0402	S-adenosylhomocysteine deaminase activity
G3A50_RS05910	COG2249	NAD(P)H dehydrogenase (quinone) activity
G3A50_RS05920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3A50_RS05940	COG1653	transport
G3A50_RS05955	COG3842	ATPase activity
G3A50_RS05960	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G3A50_RS05970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G3A50_RS05975	COG2003	Belongs to the UPF0758 family
G3A50_RS05980	COG0024	Methionine aminopeptidase
G3A50_RS05990	COG0436	Aminotransferase
G3A50_RS06000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3A50_RS06005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G3A50_RS06015	COG0494	nUDIX hydrolase
G3A50_RS06030	COG1802	Transcriptional regulator
G3A50_RS06045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3A50_RS06050	COG4191	Histidine kinase
G3A50_RS06065	COG3960	tartronate-semialdehyde synthase activity
G3A50_RS06070	COG3622	Belongs to the hyi family
G3A50_RS06075	COG2084	Dehydrogenase
G3A50_RS06080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G3A50_RS06085	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3A50_RS06090	COG0045	succinate-CoA ligase (ADP-forming) activity
G3A50_RS06095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G3A50_RS06105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G3A50_RS06110	COG2514	catechol 2,3-dioxygenase activity
G3A50_RS06130	COG3895	Periplasmic Protein
G3A50_RS06140	COG0800	Aldolase
G3A50_RS06145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3A50_RS06155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3A50_RS06160	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
G3A50_RS06175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3A50_RS06190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS06200	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3A50_RS06200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3A50_RS06210	COG1760	l-serine dehydratase
G3A50_RS06260	COG1902	pentaerythritol trinitrate reductase activity
G3A50_RS06260	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3A50_RS06265	COG2181	nitrate reductase activity
G3A50_RS06265	COG0247	lactate metabolic process
G3A50_RS06285	COG1012	belongs to the aldehyde dehydrogenase family
G3A50_RS06295	COG4176	ABC-type proline glycine betaine transport system permease component
G3A50_RS06305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3A50_RS06310	COG2233	PERMEase
G3A50_RS06315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G3A50_RS06320	COG0037	tRNA processing
G3A50_RS06330	COG2885	chlorophyll binding
G3A50_RS06335	COG0823	Involved in the tonB-independent uptake of proteins
G3A50_RS06350	COG0811	peptide transport
G3A50_RS06355	COG0824	Thioesterase
G3A50_RS06370	COG2255	four-way junction helicase activity
G3A50_RS06375	COG0632	four-way junction helicase activity
G3A50_RS06380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G3A50_RS06395	COG0217	transcriptional regulatory protein
G3A50_RS06400	COG1692	metallophosphoesterase
G3A50_RS06415	COG0604	alcohol dehydrogenase
G3A50_RS06430	COG0254	rRNA binding
G3A50_RS06435	COG1132	(ABC) transporter
G3A50_RS06455	COG0483	inositol monophosphate 1-phosphatase activity
G3A50_RS06485	COG3588	fructose-bisphosphate aldolase
G3A50_RS06495	COG0352	thiamine-phosphate diphosphorylase activity
G3A50_RS06510	COG1678	Uncharacterized ACR, COG1678
G3A50_RS06520	COG0678	peroxiredoxin activity
G3A50_RS06555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G3A50_RS06560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G3A50_RS06565	COG0328	RNA-DNA hybrid ribonuclease activity
G3A50_RS06575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G3A50_RS06625	COG0114	fumarate hydratase activity
G3A50_RS06640	COG0330	HflC and HflK could
G3A50_RS06645	COG0330	HflC and HflK could
G3A50_RS06680	COG3750	Belongs to the UPF0335 family
G3A50_RS06690	COG2989	Protein conserved in bacteria
G3A50_RS06700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G3A50_RS06710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G3A50_RS06715	COG0560	Phosphoserine phosphatase
G3A50_RS06725	COG0277	FAD linked oxidase domain protein
G3A50_RS06740	COG2264	protein methyltransferase activity
G3A50_RS06750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS06760	COG0006	proline dipeptidase activity
G3A50_RS06770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G3A50_RS06775	COG0497	DNA recombination
G3A50_RS06780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3A50_RS06790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G3A50_RS06795	COG0849	cell division
G3A50_RS06800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G3A50_RS06805	COG1181	Belongs to the D-alanine--D-alanine ligase family
G3A50_RS06815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3A50_RS06820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G3A50_RS06830	COG3706	GGDEF domain
G3A50_RS06835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G3A50_RS06845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G3A50_RS06850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G3A50_RS06855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G3A50_RS06870	COG0275	rRNA processing
G3A50_RS06875	COG2001	Belongs to the MraZ family
G3A50_RS06880	COG3023	N-Acetylmuramoyl-L-alanine amidase
G3A50_RS06895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G3A50_RS06920	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G3A50_RS06925	COG0469	pyruvate kinase activity
G3A50_RS06935	COG1999	signal sequence binding
G3A50_RS06940	COG3034	peptidoglycan biosynthetic process
G3A50_RS06960	COG1215	transferase activity, transferring glycosyl groups
G3A50_RS06990	COG1921	L-seryl-tRNASec selenium transferase activity
G3A50_RS07000	COG2864	formate dehydrogenase
G3A50_RS07005	COG0437	4 iron, 4 sulfur cluster binding
G3A50_RS07015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3A50_RS07020	COG1305	Transglutaminase-like
G3A50_RS07025	COG0709	Synthesizes selenophosphate from selenide and ATP
G3A50_RS07030	COG1733	regulation of RNA biosynthetic process
G3A50_RS07035	COG0702	epimerase
G3A50_RS07040	COG0583	DNA-binding transcription factor activity
G3A50_RS07045	COG2814	Major facilitator Superfamily
G3A50_RS07055	COG1309	transcriptional regulator
G3A50_RS07060	COG3707	response regulator
G3A50_RS07065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3A50_RS07090	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G3A50_RS07105	COG0745	RESPONSE REGULATOR receiver
G3A50_RS07110	COG0642	Histidine kinase
G3A50_RS07120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3A50_RS07125	COG0842	Transport permease protein
G3A50_RS07125	COG1129	ABC transporter
G3A50_RS07130	COG0842	Transport permease protein
G3A50_RS07135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3A50_RS07145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G3A50_RS07150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3A50_RS07165	COG1349	DNA-binding transcription factor activity
G3A50_RS07175	COG4948	Mandelate Racemase Muconate Lactonizing
G3A50_RS07180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3A50_RS07200	COG1309	transcriptional regulator
G3A50_RS07205	COG0604	alcohol dehydrogenase
G3A50_RS07210	COG1802	Transcriptional regulator
G3A50_RS07215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS07220	COG0765	amino acid transport
G3A50_RS07225	COG1126	abc transporter atp-binding protein
G3A50_RS07230	COG0402	S-adenosylhomocysteine deaminase activity
G3A50_RS07240	COG2358	TRAP transporter, solute receptor (TAXI family
G3A50_RS07255	COG1802	Transcriptional regulator
G3A50_RS07260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS07265	COG4597	amino acid ABC transporter
G3A50_RS07270	COG0765	amino acid transport
G3A50_RS07275	COG1126	abc transporter atp-binding protein
G3A50_RS07290	COG1304	FMN binding
G3A50_RS07295	COG1278	Cold shock
G3A50_RS07320	COG2326	polyphosphate kinase activity
G3A50_RS07325	COG2183	response to ionizing radiation
G3A50_RS07370	COG1116	anion transmembrane transporter activity
G3A50_RS07375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS07390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3A50_RS07410	COG1595	DNA-templated transcription, initiation
G3A50_RS07425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3A50_RS07450	COG0395	ABC-type sugar transport system, permease component
G3A50_RS07470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3A50_RS07480	COG1802	Transcriptional regulator
G3A50_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS07490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3A50_RS07510	COG0765	amino acid transport
G3A50_RS07525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G3A50_RS07530	COG1984	allophanate hydrolase subunit 2
G3A50_RS07545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3A50_RS07550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3A50_RS07555	COG0504	CTP synthase activity
G3A50_RS07565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS07575	COG1126	abc transporter atp-binding protein
G3A50_RS07580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3A50_RS07590	COG0006	proline dipeptidase activity
G3A50_RS07595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3A50_RS07600	COG0436	Aminotransferase
G3A50_RS07625	COG1904	glucuronate isomerase
G3A50_RS07630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3A50_RS07640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3A50_RS07650	COG1802	Transcriptional regulator
G3A50_RS07655	COG1312	Catalyzes the dehydration of D-mannonate
G3A50_RS07660	COG0246	Mannitol dehydrogenase
G3A50_RS07665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3A50_RS07675	COG0659	secondary active sulfate transmembrane transporter activity
G3A50_RS07680	COG0640	Transcriptional regulator
G3A50_RS07685	COG0450	alkyl hydroperoxide reductase
G3A50_RS07760	COG4451	ribulose bisphosphate carboxylase, small
G3A50_RS07765	COG1850	ribulose-bisphosphate carboxylase activity
G3A50_RS07785	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G3A50_RS07815	COG4948	Mandelate Racemase Muconate Lactonizing
G3A50_RS07820	COG2271	Major facilitator Superfamily
G3A50_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS07830	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3A50_RS07840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G3A50_RS07855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3A50_RS07860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3A50_RS07865	COG0174	glutamine synthetase
G3A50_RS07875	COG2066	Belongs to the glutaminase family
G3A50_RS07880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G3A50_RS07915	COG0747	negative chemotaxis
G3A50_RS07920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3A50_RS07940	COG2610	gluconate transmembrane transporter activity
G3A50_RS07950	COG2235	arginine
G3A50_RS07970	COG0651	ATP synthesis coupled electron transport
G3A50_RS07975	COG0651	ATP synthesis coupled electron transport
G3A50_RS08005	COG2207	Transcriptional regulator
G3A50_RS08015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3A50_RS08030	COG0628	permease
G3A50_RS08040	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G3A50_RS08060	COG0583	DNA-binding transcription factor activity
G3A50_RS08090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G3A50_RS08100	COG1175	transmembrane transport
G3A50_RS08110	COG3842	ATPase activity
G3A50_RS08115	COG1349	DNA-binding transcription factor activity
G3A50_RS08135	COG0559	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS08145	COG1396	sequence-specific DNA binding
G3A50_RS08150	COG2423	ornithine cyclodeaminase activity
G3A50_RS08170	COG0604	alcohol dehydrogenase
G3A50_RS08170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G3A50_RS08170	COG3321	synthase
G3A50_RS08170	COG4221	oxidoreductase activity
G3A50_RS08175	COG0583	DNA-binding transcription factor activity
G3A50_RS08195	COG3851	Histidine kinase
G3A50_RS08200	COG0714	Associated with various cellular activities
G3A50_RS08240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3A50_RS08245	COG1012	belongs to the aldehyde dehydrogenase family
G3A50_RS08255	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3A50_RS08260	COG1177	transmembrane transport
G3A50_RS08265	COG3842	ATPase activity
G3A50_RS08270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3A50_RS08275	COG0277	FAD linked oxidase domain protein
G3A50_RS08280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS08285	COG4941	Belongs to the sigma-70 factor family
G3A50_RS08290	COG3795	YCII-related domain
G3A50_RS08325	COG0745	RESPONSE REGULATOR receiver
G3A50_RS08345	COG1115	amino acid carrier protein
G3A50_RS08350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G3A50_RS08355	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G3A50_RS08380	COG1363	Peptidase, m42
G3A50_RS08385	COG0189	ligase activity
G3A50_RS08385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G3A50_RS08390	COG0367	asparagine synthase
G3A50_RS08440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G3A50_RS08455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G3A50_RS08460	COG0366	Alpha amylase catalytic
G3A50_RS08465	COG1396	sequence-specific DNA binding
G3A50_RS08475	COG0077	Prephenate dehydratase
G3A50_RS08475	COG1605	Chorismate mutase
G3A50_RS08480	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G3A50_RS08485	COG3474	cytochrome
G3A50_RS08490	COG4166	transmembrane transport
G3A50_RS08500	COG4174	ABC transporter (Permease)
G3A50_RS08505	COG4239	(ABC) transporter, permease
G3A50_RS08510	COG4172	Belongs to the ABC transporter superfamily
G3A50_RS08515	COG0494	nUDIX hydrolase
G3A50_RS08530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3A50_RS08545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G3A50_RS08550	COG0484	heat shock protein binding
G3A50_RS08560	COG0259	pyridoxamine-phosphate oxidase activity
G3A50_RS08565	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS08580	COG1376	ErfK ybiS ycfS ynhG family protein
G3A50_RS08580	COG1388	LysM domain
G3A50_RS08585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G3A50_RS08595	COG0546	phosphoglycolate phosphatase activity
G3A50_RS08605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3A50_RS08610	COG0288	reversible hydration of carbon dioxide
G3A50_RS08630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3A50_RS08655	COG1846	Transcriptional regulator
G3A50_RS08660	COG0410	ABC transporter
G3A50_RS08695	COG1376	ErfK ybiS ycfS ynhG family protein
G3A50_RS08700	COG2226	methyltransferase
G3A50_RS08705	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G3A50_RS08715	COG0756	dUTP diphosphatase activity
G3A50_RS08720	COG1959	2 iron, 2 sulfur cluster binding
G3A50_RS08730	COG2205	protein histidine kinase activity
G3A50_RS08735	COG3178	'Phosphotransferase
G3A50_RS08740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G3A50_RS08745	COG2887	Belongs to the helicase family. UvrD subfamily
G3A50_RS08750	COG1074	ATP-dependent DNA helicase activity
G3A50_RS08770	COG0670	Belongs to the BI1 family
G3A50_RS08780	COG1595	DNA-templated transcription, initiation
G3A50_RS08795	COG3685	Protein conserved in bacteria
G3A50_RS08805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3A50_RS08810	COG1473	amidohydrolase
G3A50_RS08825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G3A50_RS08865	COG0483	inositol monophosphate 1-phosphatase activity
G3A50_RS08880	COG1519	Transferase
G3A50_RS08885	COG1663	tetraacyldisaccharide 4'-kinase activity
G3A50_RS08895	COG1570	exodeoxyribonuclease VII activity
G3A50_RS08900	COG0752	glycyl-tRNA synthetase alpha subunit
G3A50_RS08905	COG0751	glycine-tRNA ligase activity
G3A50_RS08915	COG2259	Doxx family
G3A50_RS08920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G3A50_RS08920	COG0574	Belongs to the PEP-utilizing enzyme family
G3A50_RS08930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G3A50_RS08940	COG2059	Chromate
G3A50_RS08945	COG2059	Chromate
G3A50_RS08955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3A50_RS08965	COG2171	N-acyltransferase activity
G3A50_RS08970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3A50_RS08995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G3A50_RS09005	COG0284	orotidine-5'-phosphate decarboxylase activity
G3A50_RS09010	COG0431	NADPH-dependent FMN reductase
G3A50_RS09015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3A50_RS09020	COG0484	heat shock protein binding
G3A50_RS09025	COG0443	Heat shock 70 kDa protein
G3A50_RS09055	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G3A50_RS09065	COG1309	transcriptional regulator
G3A50_RS09070	COG3158	transport of potassium into the cell
G3A50_RS09085	COG2326	polyphosphate kinase activity
G3A50_RS09090	COG5002	protein histidine kinase activity
G3A50_RS09100	COG0573	inorganic phosphate transmembrane transporter activity
G3A50_RS09110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G3A50_RS09115	COG0704	Plays a role in the regulation of phosphate uptake
G3A50_RS09120	COG0745	RESPONSE REGULATOR receiver
G3A50_RS09130	COG0583	DNA-binding transcription factor activity
G3A50_RS09150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3A50_RS09160	COG0180	Tryptophanyl-tRNA synthetase
G3A50_RS09170	COG0435	Glutathione S-transferase
G3A50_RS09175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G3A50_RS09180	COG1214	PFAM Peptidase M22, glycoprotease
G3A50_RS09205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3A50_RS09215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G3A50_RS09220	COG1253	flavin adenine dinucleotide binding
G3A50_RS09225	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G3A50_RS09230	COG1396	sequence-specific DNA binding
G3A50_RS09235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G3A50_RS09240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G3A50_RS09290	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
G3A50_RS09295	COG0519	Catalyzes the synthesis of GMP from XMP
G3A50_RS09300	COG0354	folic acid binding
G3A50_RS09305	COG1764	response to oxidative stress
G3A50_RS09310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3A50_RS09310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3A50_RS09315	COG0101	tRNA pseudouridine synthase activity
G3A50_RS09320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G3A50_RS09325	COG3920	Histidine kinase
G3A50_RS09340	COG0196	riboflavin kinase activity
G3A50_RS09345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G3A50_RS09350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G3A50_RS09360	COG0612	Peptidase, M16
G3A50_RS09365	COG0612	Peptidase, M16
G3A50_RS09390	COG0277	FAD linked oxidase domain protein
G3A50_RS09400	COG0277	FAD linked oxidase domain protein
G3A50_RS09405	COG0247	lactate metabolic process
G3A50_RS09435	COG3454	Phosphonate metabolism
G3A50_RS09440	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G3A50_RS09450	COG0616	signal peptide processing
G3A50_RS09455	COG0776	regulation of translation
G3A50_RS09470	COG4208	sulfate ABC transporter
G3A50_RS09480	COG4150	thiosulfate binding
G3A50_RS09485	COG0135	phosphoribosylanthranilate isomerase activity
G3A50_RS09490	COG0133	tryptophan synthase activity
G3A50_RS09495	COG0159	tryptophan synthase activity
G3A50_RS09500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G3A50_RS09510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G3A50_RS09520	COG0742	ribosomal rna small subunit methyltransferase
G3A50_RS09525	COG1187	pseudouridine synthase activity
G3A50_RS09530	COG0590	tRNA wobble adenosine to inosine editing
G3A50_RS09535	COG1752	Esterase of the alpha-beta hydrolase superfamily
G3A50_RS09545	COG0577	efflux transmembrane transporter activity
G3A50_RS09545	COG1136	(ABC) transporter
G3A50_RS09550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3A50_RS09575	COG0142	geranyltranstransferase activity
G3A50_RS09580	COG1742	UPF0060 membrane protein
G3A50_RS09585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G3A50_RS09590	COG0779	Required for maturation of 30S ribosomal subunits
G3A50_RS09605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G3A50_RS09605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G3A50_RS09610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G3A50_RS09615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G3A50_RS09620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G3A50_RS09625	COG1185	polyribonucleotide nucleotidyltransferase activity
G3A50_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS09675	COG1802	Transcriptional regulator
G3A50_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS09695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS09715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3A50_RS09720	COG3938	Belongs to the proline racemase family
G3A50_RS09725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3A50_RS09730	COG3842	ATPase activity
G3A50_RS09745	COG2204	response regulator
G3A50_RS09780	COG0625	glutathione transferase activity
G3A50_RS09785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G3A50_RS09795	COG0640	Transcriptional regulator
G3A50_RS09810	COG0539	negative regulation of cytoplasmic translation
G3A50_RS09815	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G3A50_RS09835	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G3A50_RS09840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G3A50_RS09875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G3A50_RS09880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G3A50_RS09885	COG0561	phosphatase activity
G3A50_RS09900	COG3842	ATPase activity
G3A50_RS09905	COG1178	ABC-type Fe3 transport system permease component
G3A50_RS09910	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3A50_RS09920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3A50_RS09920	COG0475	glutathione-regulated potassium exporter activity
G3A50_RS09930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G3A50_RS09935	COG3383	formate dehydrogenase (NAD+) activity
G3A50_RS09950	COG0606	chelatase, subunit chli
G3A50_RS09960	COG0071	Belongs to the small heat shock protein (HSP20) family
G3A50_RS09970	COG0189	ligase activity
G3A50_RS09975	COG0792	nuclease activity
G3A50_RS09980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G3A50_RS09990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G3A50_RS09995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G3A50_RS10000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G3A50_RS10010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G3A50_RS10025	COG1072	(Pantothenic acid kinase))
G3A50_RS10030	COG0140	phosphoribosyl-ATP diphosphatase activity
G3A50_RS10035	COG0107	imidazoleglycerol-phosphate synthase activity
G3A50_RS10040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G3A50_RS10045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G3A50_RS10055	COG0131	Imidazoleglycerol-phosphate dehydratase
G3A50_RS10065	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G3A50_RS10070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G3A50_RS10085	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G3A50_RS10095	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G3A50_RS10100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G3A50_RS10105	COG0237	dephospho-CoA kinase activity
G3A50_RS10110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G3A50_RS10115	COG0424	maF-like protein
G3A50_RS10120	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G3A50_RS10125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G3A50_RS10135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G3A50_RS10145	COG1331	Highly conserved protein containing a thioredoxin domain
G3A50_RS10150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G3A50_RS10155	COG0445	tRNA wobble uridine modification
G3A50_RS10160	COG0357	Ribosomal RNA small subunit methyltransferase G
G3A50_RS10185	COG0495	leucyl-tRNA aminoacylation
G3A50_RS10190	COG2203	Gaf domain
G3A50_RS10190	COG5001	Diguanylate cyclase
G3A50_RS10190	COG3706	GGDEF domain
G3A50_RS10190	COG4251	negative regulation of phosphorylation
G3A50_RS10195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G3A50_RS10205	COG0745	RESPONSE REGULATOR receiver
G3A50_RS10210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3A50_RS10225	COG0501	Belongs to the peptidase M48B family
G3A50_RS10235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G3A50_RS10245	COG1566	PFAM secretion protein HlyD family protein
G3A50_RS10260	COG2957	Belongs to the agmatine deiminase family
G3A50_RS10280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G3A50_RS10285	COG4133	protoheme IX ABC transporter activity
G3A50_RS10290	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G3A50_RS10295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3A50_RS10300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G3A50_RS10305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G3A50_RS10310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G3A50_RS10315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G3A50_RS10320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G3A50_RS10320	COG0352	thiamine-phosphate diphosphorylase activity
G3A50_RS10320	COG0351	phosphomethylpyrimidine kinase
G3A50_RS10325	COG2186	Transcriptional regulator
G3A50_RS10330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G3A50_RS10335	COG0513	Belongs to the DEAD box helicase family
G3A50_RS10340	COG2226	methyltransferase
G3A50_RS10345	COG2813	Specifically methylates the guanine in position
G3A50_RS10345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3A50_RS10350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3A50_RS10360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3A50_RS10365	COG0287	Prephenate dehydrogenase
G3A50_RS10380	COG0583	DNA-binding transcription factor activity
G3A50_RS10390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3A50_RS10395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS10410	COG0165	Argininosuccinate lyase
G3A50_RS10415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3A50_RS10420	COG0697	spore germination
G3A50_RS10425	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3A50_RS10430	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G3A50_RS10435	COG2086	electron transfer activity
G3A50_RS10455	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
G3A50_RS10470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G3A50_RS10475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G3A50_RS10480	COG0799	negative regulation of ribosome biogenesis
G3A50_RS10485	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G3A50_RS10495	COG0793	Belongs to the peptidase S41A family
G3A50_RS10505	COG0494	nUDIX hydrolase
G3A50_RS10510	COG1309	transcriptional regulator
G3A50_RS10530	COG3118	belongs to the thioredoxin family
G3A50_RS10540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G3A50_RS10545	COG1802	Transcriptional regulator
G3A50_RS10550	COG1663	tetraacyldisaccharide 4'-kinase activity
G3A50_RS10550	COG2835	tetraacyldisaccharide 4'-kinase activity
G3A50_RS10555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3A50_RS10565	COG0347	Belongs to the P(II) protein family
G3A50_RS10570	COG0004	ammonium transporteR
G3A50_RS10575	COG0436	Aminotransferase
G3A50_RS10580	COG1674	ftsk spoiiie
G3A50_RS10600	COG0019	diaminopimelate decarboxylase activity
G3A50_RS10615	COG2884	Cell division ATP-binding protein ftsE
G3A50_RS10635	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G3A50_RS10645	COG0129	dihydroxy-acid dehydratase activity
G3A50_RS10650	COG0363	glucosamine-6-phosphate deaminase activity
G3A50_RS10655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G3A50_RS10675	COG1802	Transcriptional regulator
G3A50_RS10700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS10705	COG1116	anion transmembrane transporter activity
G3A50_RS10715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3A50_RS10720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS10740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3A50_RS10745	COG1063	alcohol dehydrogenase
G3A50_RS10765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3A50_RS10775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3A50_RS10775	COG2080	2 iron, 2 sulfur cluster binding
G3A50_RS10790	COG1309	transcriptional regulator
G3A50_RS10800	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS10810	COG4957	zinc ion binding
G3A50_RS10820	COG0154	amidase activity
G3A50_RS10825	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G3A50_RS10840	COG0559	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS10850	COG0583	DNA-binding transcription factor activity
G3A50_RS10855	COG1275	C4-dicarboxylate transporter malic acid transport protein
G3A50_RS10870	COG3119	arylsulfatase activity
G3A50_RS10880	COG0072	phenylalanine-tRNA ligase activity
G3A50_RS10880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3A50_RS10890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G3A50_RS10895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G3A50_RS10900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G3A50_RS10910	COG1968	undecaprenyl-diphosphatase activity
G3A50_RS10915	COG0702	epimerase
G3A50_RS10925	COG0582	viral genome integration into host DNA
G3A50_RS10940	COG3706	GGDEF domain
G3A50_RS10950	COG0010	Belongs to the arginase family
G3A50_RS10975	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3A50_RS10985	COG0513	Belongs to the DEAD box helicase family
G3A50_RS10990	COG3300	MHYT domain
G3A50_RS10990	COG5001	Diguanylate cyclase
G3A50_RS11030	COG3852	Histidine kinase
G3A50_RS11035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G3A50_RS11040	COG0594	ribonuclease P activity
G3A50_RS11045	COG0706	membrane insertase activity
G3A50_RS11050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G3A50_RS11060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3A50_RS11065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G3A50_RS11070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G3A50_RS11080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G3A50_RS11095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G3A50_RS11110	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G3A50_RS11120	COG0583	DNA-binding transcription factor activity
G3A50_RS11135	COG0174	glutamine synthetase
G3A50_RS11140	COG3842	ATPase activity
G3A50_RS11145	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3A50_RS11150	COG1177	transmembrane transport
G3A50_RS11160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G3A50_RS11165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS11170	COG0586	Pfam SNARE associated Golgi protein
G3A50_RS11180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G3A50_RS11185	COG1309	transcriptional regulator
G3A50_RS11190	COG0440	acetolactate synthase activity
G3A50_RS11195	COG0028	Belongs to the TPP enzyme family
G3A50_RS11205	COG0588	phosphoglycerate mutase activity
G3A50_RS11225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G3A50_RS11240	COG2084	Dehydrogenase
G3A50_RS11250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3A50_RS11255	COG1024	Enoyl-CoA hydratase
G3A50_RS11260	COG0145	ligase activity
G3A50_RS11265	COG4647	ligase activity
G3A50_RS11270	COG0145	ligase activity
G3A50_RS11275	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
G3A50_RS11280	COG0243	molybdopterin cofactor binding
G3A50_RS11285	COG1271	oxidase subunit
G3A50_RS11290	COG1294	oxidase, subunit
G3A50_RS11305	COG2072	flavoprotein involved in K transport
G3A50_RS11315	COG0438	transferase activity, transferring glycosyl groups
G3A50_RS11320	COG2144	transferase activity, transferring acyl groups
G3A50_RS11330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G3A50_RS11345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3A50_RS11360	COG1136	(ABC) transporter
G3A50_RS11360	COG0577	efflux transmembrane transporter activity
G3A50_RS11365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3A50_RS11380	COG2205	protein histidine kinase activity
G3A50_RS11385	COG1473	amidohydrolase
G3A50_RS11390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3A50_RS11395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS11400	COG1116	anion transmembrane transporter activity
G3A50_RS11400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS11405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS11410	COG1846	Transcriptional regulator
G3A50_RS11430	COG0601	transmembrane transport
G3A50_RS11435	COG0747	negative chemotaxis
G3A50_RS11440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G3A50_RS11445	COG1960	acyl-CoA dehydrogenase activity
G3A50_RS11450	COG0583	DNA-binding transcription factor activity
G3A50_RS11455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G3A50_RS11460	COG2079	MmgE PrpD family protein
G3A50_RS11470	COG1174	glycine betaine transport
G3A50_RS11475	COG1125	glycine betaine transport
G3A50_RS11480	COG1174	glycine betaine transport
G3A50_RS11485	COG1732	Glycine betaine
G3A50_RS11490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G3A50_RS11505	COG0438	transferase activity, transferring glycosyl groups
G3A50_RS11515	COG0438	transferase activity, transferring glycosyl groups
G3A50_RS11525	COG0110	maltose O-acetyltransferase activity
G3A50_RS11535	COG3551	Protein conserved in bacteria
G3A50_RS11550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3A50_RS11555	COG0297	glycogen (starch) synthase activity
G3A50_RS11580	COG4214	carbohydrate transport
G3A50_RS11590	COG4213	ABC transporter substrate-binding protein
G3A50_RS11595	COG0800	Aldolase
G3A50_RS11600	COG3734	2-keto-3-deoxy-galactonokinase
G3A50_RS11605	COG3386	PFAM SMP-30 Gluconolaconase
G3A50_RS11610	COG0129	dihydroxy-acid dehydratase activity
G3A50_RS11615	COG2017	converts alpha-aldose to the beta-anomer
G3A50_RS11645	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS11650	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS11655	COG1129	ABC transporter
G3A50_RS11660	COG1879	ABC-type sugar transport system periplasmic component
G3A50_RS11665	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3A50_RS11685	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3A50_RS11690	COG3938	Belongs to the proline racemase family
G3A50_RS11695	COG4948	Mandelate Racemase Muconate Lactonizing
G3A50_RS11700	COG3938	Belongs to the proline racemase family
G3A50_RS11705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3A50_RS11710	COG1126	abc transporter atp-binding protein
G3A50_RS11730	COG1802	Transcriptional regulator
G3A50_RS11740	COG4977	sequence-specific DNA binding
G3A50_RS11745	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS11755	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G3A50_RS11760	COG2186	Transcriptional regulator
G3A50_RS11765	COG4597	amino acid ABC transporter
G3A50_RS11770	COG0765	amino acid transport
G3A50_RS11775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS11790	COG0583	DNA-binding transcription factor activity
G3A50_RS11795	COG0596	Alpha beta hydrolase
G3A50_RS11820	COG0582	viral genome integration into host DNA
G3A50_RS11825	COG4566	intracellular signal transduction
G3A50_RS11855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3A50_RS11855	COG2010	Cytochrome c
G3A50_RS11860	COG2080	2 iron, 2 sulfur cluster binding
G3A50_RS11865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3A50_RS11865	COG2010	Cytochrome c
G3A50_RS11870	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS11935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3A50_RS11960	COG2223	nitrite transmembrane transporter activity
G3A50_RS11965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G3A50_RS11975	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G3A50_RS11985	COG0745	RESPONSE REGULATOR receiver
G3A50_RS11990	COG0642	Histidine kinase
G3A50_RS12000	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3A50_RS12000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G3A50_RS12005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3A50_RS12010	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G3A50_RS12045	COG3932	Exopolysaccharide synthesis, ExoD
G3A50_RS12060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3A50_RS12075	COG0587	DNA-directed DNA polymerase activity
G3A50_RS12100	COG1846	Transcriptional regulator
G3A50_RS12105	COG0583	DNA-binding transcription factor activity
G3A50_RS12110	COG0346	lactoylglutathione lyase activity
G3A50_RS12115	COG0400	carboxylic ester hydrolase activity
G3A50_RS12120	COG2321	neutral zinc metallopeptidase
G3A50_RS12125	COG0521	Mo-molybdopterin cofactor biosynthetic process
G3A50_RS12145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3A50_RS12165	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G3A50_RS12185	COG1522	sequence-specific DNA binding
G3A50_RS12190	COG1196	nuclear chromosome segregation
G3A50_RS12200	COG0356	it plays a direct role in the translocation of protons across the membrane
G3A50_RS12205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3A50_RS12210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3A50_RS12215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3A50_RS12225	COG0009	L-threonylcarbamoyladenylate synthase
G3A50_RS12230	COG0123	including yeast histone deacetylase and acetoin utilization protein
G3A50_RS12235	COG1722	exodeoxyribonuclease VII activity
G3A50_RS12245	COG3813	Protein conserved in bacteria
G3A50_RS12260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G3A50_RS12270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3A50_RS12280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G3A50_RS12280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G3A50_RS12285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G3A50_RS12290	COG1253	flavin adenine dinucleotide binding
G3A50_RS12300	COG1643	Atp-dependent helicase
G3A50_RS12320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3A50_RS12325	COG0124	histidyl-tRNA synthetase
G3A50_RS12335	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G3A50_RS12340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G3A50_RS12345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G3A50_RS12345	COG1648	precorrin-2 dehydrogenase activity
G3A50_RS12355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3A50_RS12365	COG3278	Belongs to the heme-copper respiratory oxidase family
G3A50_RS12380	COG2010	Cytochrome c
G3A50_RS12395	COG2217	Heavy metal translocating P-type atpase
G3A50_RS12415	COG1309	transcriptional regulator
G3A50_RS12420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G3A50_RS12425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G3A50_RS12445	COG2223	nitrite transmembrane transporter activity
G3A50_RS12450	COG1064	alcohol dehydrogenase
G3A50_RS12460	COG2816	NAD+ diphosphatase activity
G3A50_RS12465	COG0789	Transcriptional regulator
G3A50_RS12470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G3A50_RS12475	COG0717	Belongs to the dCTP deaminase family
G3A50_RS12485	COG2967	ApaG domain
G3A50_RS12490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G3A50_RS12505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G3A50_RS12510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G3A50_RS12525	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G3A50_RS12530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G3A50_RS12545	COG2202	Pas domain
G3A50_RS12545	COG3920	Histidine kinase
G3A50_RS12550	COG0784	Response regulator, receiver
G3A50_RS12565	COG5487	UPF0391 membrane protein
G3A50_RS12580	COG0242	peptide deformylase activity
G3A50_RS12585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3A50_RS12595	COG0450	alkyl hydroperoxide reductase
G3A50_RS12615	COG0167	dihydroorotate dehydrogenase activity
G3A50_RS12635	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3A50_RS12635	COG1793	dna ligase
G3A50_RS12650	COG1201	RNA secondary structure unwinding
G3A50_RS12665	COG0789	Transcriptional regulator
G3A50_RS12685	COG0432	Pfam Uncharacterised protein family UPF0047
G3A50_RS12700	COG5002	protein histidine kinase activity
G3A50_RS12705	COG1970	mechanosensitive ion channel activity
G3A50_RS12710	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
G3A50_RS12715	COG1088	dTDP-glucose 4,6-dehydratase activity
G3A50_RS12725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G3A50_RS12730	COG0438	transferase activity, transferring glycosyl groups
G3A50_RS12730	COG1216	Glycosyl transferase, family 2
G3A50_RS12735	COG1216	Glycosyl transferase, family 2
G3A50_RS12735	COG0438	transferase activity, transferring glycosyl groups
G3A50_RS12755	COG2226	methyltransferase
G3A50_RS12770	COG1216	Glycosyl transferase, family 2
G3A50_RS12780	COG0436	Aminotransferase
G3A50_RS12785	COG4191	Histidine kinase
G3A50_RS12790	COG4566	intracellular signal transduction
G3A50_RS12800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3A50_RS12805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G3A50_RS12815	COG0156	8-amino-7-oxononanoate synthase activity
G3A50_RS12825	COG0010	Belongs to the arginase family
G3A50_RS12840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G3A50_RS12850	COG2824	Alkylphosphonate utilization operon protein PhnA
G3A50_RS12860	COG3842	ATPase activity
G3A50_RS12875	COG0395	ABC-type sugar transport system, permease component
G3A50_RS12905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G3A50_RS12915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3A50_RS12920	COG5328	Belongs to the UPF0262 family
G3A50_RS12930	COG0424	maF-like protein
G3A50_RS12935	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G3A50_RS12955	COG0604	alcohol dehydrogenase
G3A50_RS12955	COG4221	oxidoreductase activity
G3A50_RS12955	COG3321	synthase
G3A50_RS12955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G3A50_RS12965	COG0583	DNA-binding transcription factor activity
G3A50_RS13005	COG0679	Auxin Efflux Carrier
G3A50_RS13015	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS13045	COG0850	regulation of cytokinetic process
G3A50_RS13055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G3A50_RS13070	COG2201	protein-glutamate methylesterase activity
G3A50_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS13125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G3A50_RS13140	COG2814	Major facilitator Superfamily
G3A50_RS13150	COG2814	Major facilitator Superfamily
G3A50_RS13170	COG0583	DNA-binding transcription factor activity
G3A50_RS13175	COG0667	Aldo Keto reductase
G3A50_RS13180	COG2814	Major facilitator Superfamily
G3A50_RS13185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3A50_RS13250	COG1733	regulation of RNA biosynthetic process
G3A50_RS13255	COG4993	Dehydrogenase
G3A50_RS13260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3A50_RS13270	COG0434	BtpA family
G3A50_RS13275	COG1349	DNA-binding transcription factor activity
G3A50_RS13285	COG3842	ATPase activity
G3A50_RS13290	COG0395	ABC-type sugar transport system, permease component
G3A50_RS13300	COG1175	transmembrane transport
G3A50_RS13310	COG1129	ABC transporter
G3A50_RS13315	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS13320	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3A50_RS13325	COG2186	Transcriptional regulator
G3A50_RS13335	COG3395	kinase activity
G3A50_RS13340	COG0235	Class ii aldolase
G3A50_RS13345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G3A50_RS13350	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G3A50_RS13355	COG1053	succinate dehydrogenase
G3A50_RS13360	COG0583	DNA-binding transcription factor activity
G3A50_RS13370	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS13380	COG4608	Belongs to the ABC transporter superfamily
G3A50_RS13400	COG0747	negative chemotaxis
G3A50_RS13510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G3A50_RS13515	COG1704	LemA family
G3A50_RS13525	COG3706	GGDEF domain
G3A50_RS13530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS13545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS13550	COG4597	amino acid ABC transporter
G3A50_RS13555	COG0765	amino acid transport
G3A50_RS13560	COG1126	abc transporter atp-binding protein
G3A50_RS13565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS13580	COG1012	belongs to the aldehyde dehydrogenase family
G3A50_RS13585	COG0473	3-isopropylmalate dehydrogenase activity
G3A50_RS13595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3A50_RS13605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3A50_RS13610	COG1414	Transcriptional regulator
G3A50_RS13635	COG2202	Pas domain
G3A50_RS13635	COG3920	Histidine kinase
G3A50_RS13645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3A50_RS13650	COG1845	cytochrome c oxidase, subunit III
G3A50_RS13670	COG0765	amino acid transport
G3A50_RS13690	COG0583	DNA-binding transcription factor activity
G3A50_RS13700	COG0667	Aldo Keto reductase
G3A50_RS13710	COG0583	DNA-binding transcription factor activity
G3A50_RS13740	COG0583	DNA-binding transcription factor activity
G3A50_RS13755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3A50_RS13760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3A50_RS13815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3A50_RS13855	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3A50_RS13865	COG1802	Transcriptional regulator
G3A50_RS13870	COG0473	3-isopropylmalate dehydrogenase activity
G3A50_RS13875	COG1012	belongs to the aldehyde dehydrogenase family
G3A50_RS13900	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3A50_RS13905	COG3622	Belongs to the hyi family
G3A50_RS13915	COG2706	6-phosphogluconolactonase activity
G3A50_RS13950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS13955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS13960	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3A50_RS13970	COG0726	polysaccharide deacetylase
G3A50_RS13985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G3A50_RS14000	COG1073	alpha beta
G3A50_RS14035	COG0667	Aldo Keto reductase
G3A50_RS14040	COG1120	ATPase activity
G3A50_RS14045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3A50_RS14050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3A50_RS14055	COG4607	ABC-type enterochelin transport system periplasmic component
G3A50_RS14125	COG1064	alcohol dehydrogenase
G3A50_RS14165	COG0667	Aldo Keto reductase
G3A50_RS14215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G3A50_RS14220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G3A50_RS14230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G3A50_RS14325	COG4387	Mu-like prophage protein GP36
G3A50_RS14335	COG4397	Mu-like prophage major head subunit gpT
G3A50_RS14360	COG4383	Mu-like prophage protein gp29
G3A50_RS14365	COG4373	Mu-like prophage FluMu protein gp28
G3A50_RS14395	COG3179	chitinase
G3A50_RS14485	COG2842	Transposition protein
G3A50_RS14530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G3A50_RS14550	COG3842	ATPase activity
G3A50_RS14555	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3A50_RS14560	COG1177	transmembrane transport
G3A50_RS14580	COG4783	chaperone-mediated protein folding
G3A50_RS14585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G3A50_RS14595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G3A50_RS14615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G3A50_RS14620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G3A50_RS14635	COG1309	transcriptional regulator
G3A50_RS14660	COG3220	belongs to the UPF0276 family
G3A50_RS14695	COG0670	Belongs to the BI1 family
G3A50_RS14705	COG4181	ATPase activity
G3A50_RS14715	COG0667	Aldo Keto reductase
G3A50_RS14720	COG2917	probably involved in intracellular septation
G3A50_RS14730	COG0552	protein localization to endoplasmic reticulum
G3A50_RS14735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3A50_RS14740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G3A50_RS14750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G3A50_RS14765	COG0137	argininosuccinate synthase activity
G3A50_RS14775	COG1994	Peptidase M50
G3A50_RS14795	COG1247	-acetyltransferase
G3A50_RS14800	COG1872	DUF167
G3A50_RS14820	COG0477	Major facilitator Superfamily
G3A50_RS14825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G3A50_RS14830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3A50_RS14835	COG1845	cytochrome c oxidase, subunit III
G3A50_RS14840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G3A50_RS14860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G3A50_RS14880	COG1021	2,3-dihydroxybenzoate-AMP ligase
G3A50_RS14885	COG3433	isochorismatase activity
G3A50_RS14885	COG1535	isochorismatase
G3A50_RS14890	COG1535	isochorismatase
G3A50_RS14890	COG3433	isochorismatase activity
G3A50_RS14895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G3A50_RS14900	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS14905	COG1120	ATPase activity
G3A50_RS14910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3A50_RS14920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G3A50_RS14930	COG0400	carboxylic ester hydrolase activity
G3A50_RS14935	COG0739	heme binding
G3A50_RS14955	COG1053	succinate dehydrogenase
G3A50_RS14965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3A50_RS14980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G3A50_RS14990	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G3A50_RS15000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3A50_RS15005	COG1280	lysine exporter protein (LysE YggA)
G3A50_RS15010	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3A50_RS15015	COG0567	Dehydrogenase, E1 component
G3A50_RS15025	COG0039	L-malate dehydrogenase activity
G3A50_RS15035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G3A50_RS15050	COG1196	nuclear chromosome segregation
G3A50_RS15050	COG3264	Mechanosensitive ion channel
G3A50_RS15060	COG0523	cobalamin synthesis protein
G3A50_RS15065	COG1686	Belongs to the peptidase S11 family
G3A50_RS15070	COG0140	phosphoribosyl-ATP diphosphatase activity
G3A50_RS15075	COG1238	metal cluster binding
G3A50_RS15085	COG0175	sulfate reduction
G3A50_RS15095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3A50_RS15150	COG2140	Oxalate decarboxylase
G3A50_RS15160	COG0583	DNA-binding transcription factor activity
G3A50_RS15185	COG0251	oxidation-reduction process
G3A50_RS15200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3A50_RS15210	COG5001	Diguanylate cyclase
G3A50_RS15210	COG3300	MHYT domain
G3A50_RS15220	COG0730	response to heat
G3A50_RS15225	COG0668	transmembrane transport
G3A50_RS15235	COG0747	negative chemotaxis
G3A50_RS15240	COG0601	transmembrane transport
G3A50_RS15250	COG4172	Belongs to the ABC transporter superfamily
G3A50_RS15275	COG4770	biotin carboxylase activity
G3A50_RS15280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3A50_RS15285	COG3800	Transcriptional regulator
G3A50_RS15285	COG1396	sequence-specific DNA binding
G3A50_RS15295	COG0069	glutamate synthase activity
G3A50_RS15300	COG2218	PFAM glutamate synthase alpha subunit domain protein
G3A50_RS15305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G3A50_RS15320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G3A50_RS15335	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3A50_RS15335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3A50_RS15340	COG4311	Sarcosine oxidase, delta subunit
G3A50_RS15345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS15350	COG0583	DNA-binding transcription factor activity
G3A50_RS15365	COG2723	6-phospho-beta-galactosidase activity
G3A50_RS15380	COG1937	Protein conserved in bacteria
G3A50_RS15400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G3A50_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS15425	COG0656	L-ascorbic acid biosynthetic process
G3A50_RS15430	COG1122	ATPase activity
G3A50_RS15435	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G3A50_RS15440	COG1268	BioY protein
G3A50_RS15445	COG0318	PFAM AMP-dependent synthetase and ligase
G3A50_RS15450	COG0667	Aldo Keto reductase
G3A50_RS15455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G3A50_RS15475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3A50_RS15480	COG3842	ATPase activity
G3A50_RS15485	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3A50_RS15490	COG1177	transmembrane transport
G3A50_RS15505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3A50_RS15520	COG0697	spore germination
G3A50_RS15530	COG1902	pentaerythritol trinitrate reductase activity
G3A50_RS15530	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3A50_RS15535	COG0445	tRNA wobble uridine modification
G3A50_RS15550	COG4221	oxidoreductase activity
G3A50_RS15555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS15565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3A50_RS15570	COG0022	dehydrogenase e1 component
G3A50_RS15570	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3A50_RS15600	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS15605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS15610	COG1126	abc transporter atp-binding protein
G3A50_RS15615	COG0765	amino acid transport
G3A50_RS15620	COG0765	amino acid transport
G3A50_RS15635	COG1285	pathogenesis
G3A50_RS15650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G3A50_RS15675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3A50_RS15685	COG2368	4-hydroxyphenylacetate
G3A50_RS15700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3A50_RS15710	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3A50_RS15715	COG1177	transmembrane transport
G3A50_RS15720	COG3842	ATPase activity
G3A50_RS15730	COG1999	signal sequence binding
G3A50_RS15770	COG0028	Belongs to the TPP enzyme family
G3A50_RS15790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G3A50_RS15800	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3A50_RS15805	COG0268	Binds directly to 16S ribosomal RNA
G3A50_RS15810	COG1024	Enoyl-CoA hydratase
G3A50_RS15815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G3A50_RS15830	COG1565	acr, cog1565
G3A50_RS15830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G3A50_RS15835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3A50_RS15840	COG0109	protoheme IX farnesyltransferase activity
G3A50_RS15865	COG3346	SURF1 family
G3A50_RS15875	COG0612	Peptidase, M16
G3A50_RS15895	COG1840	ABC-type Fe3 transport system, periplasmic component
G3A50_RS15905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3A50_RS15930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G3A50_RS15935	COG0459	protein refolding
G3A50_RS15945	COG2095	MarC family integral membrane protein
G3A50_RS15950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G3A50_RS15960	COG1294	oxidase, subunit
G3A50_RS15965	COG1271	oxidase subunit
G3A50_RS15970	COG1573	uracil-dna glycosylase
G3A50_RS15990	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G3A50_RS15995	COG3639	organic phosphonate transmembrane transporter activity
G3A50_RS16005	COG4178	(ABC) transporter
G3A50_RS16010	COG0038	chloride channel
G3A50_RS16015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS16020	COG3214	Protein conserved in bacteria
G3A50_RS16025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS16035	COG0025	NhaP-type Na H and K H
G3A50_RS16060	COG1230	cation diffusion facilitator family transporter
G3A50_RS16075	COG0730	response to heat
G3A50_RS16095	COG0784	Response regulator, receiver
G3A50_RS16100	COG1703	isobutyryl-CoA mutase activity
G3A50_RS16110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3A50_RS16115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3A50_RS16120	COG0433	COG0433 Predicted ATPase
G3A50_RS16125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G3A50_RS16130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G3A50_RS16150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G3A50_RS16165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3A50_RS16190	COG2166	iron-sulfur cluster assembly
G3A50_RS16230	COG2983	Belongs to the UPF0260 family
G3A50_RS16235	COG1304	FMN binding
G3A50_RS16245	COG0717	Belongs to the dCTP deaminase family
G3A50_RS16275	COG4695	Portal protein
G3A50_RS16295	COG5640	endopeptidase activity
G3A50_RS16385	COG0745	RESPONSE REGULATOR receiver
G3A50_RS16390	COG2205	protein histidine kinase activity
G3A50_RS16400	COG4235	cytochrome complex assembly
G3A50_RS16405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G3A50_RS16410	COG1138	Cytochrome C-type biogenesis protein
G3A50_RS16415	COG3088	subunit of a heme lyase
G3A50_RS16420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3A50_RS16425	COG0745	RESPONSE REGULATOR receiver
G3A50_RS16435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G3A50_RS16440	COG2205	protein histidine kinase activity
G3A50_RS16440	COG2202	Pas domain
G3A50_RS16450	COG4251	negative regulation of phosphorylation
G3A50_RS16450	COG5001	Diguanylate cyclase
G3A50_RS16450	COG3706	GGDEF domain
G3A50_RS16450	COG2203	Gaf domain
G3A50_RS16455	COG0308	aminopeptidase N
G3A50_RS16460	COG2755	lipolytic protein G-D-S-L family
G3A50_RS16460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G3A50_RS16495	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
G3A50_RS16505	COG0702	epimerase
G3A50_RS16525	COG1229	Formylmethanofuran dehydrogenase subunit A
G3A50_RS16530	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
G3A50_RS16535	COG2218	PFAM glutamate synthase alpha subunit domain protein
G3A50_RS16540	COG2239	Acts as a magnesium transporter
G3A50_RS16580	COG0277	FAD linked oxidase domain protein
G3A50_RS16590	COG0848	biopolymer transport protein
G3A50_RS16600	COG4608	Belongs to the ABC transporter superfamily
G3A50_RS16605	COG0444	Belongs to the ABC transporter superfamily
G3A50_RS16610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3A50_RS16615	COG0601	transmembrane transport
G3A50_RS16620	COG0747	negative chemotaxis
G3A50_RS16630	COG1959	2 iron, 2 sulfur cluster binding
G3A50_RS16640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G3A50_RS16675	COG0668	transmembrane transport
G3A50_RS16680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G3A50_RS16685	COG2224	Isocitrate lyase
G3A50_RS16695	COG1396	sequence-specific DNA binding
G3A50_RS16695	COG3800	Transcriptional regulator
G3A50_RS16710	COG2226	methyltransferase
G3A50_RS16725	COG0300	oxidoreductase activity
G3A50_RS16775	COG3321	synthase
G3A50_RS16775	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS16775	COG0604	alcohol dehydrogenase
G3A50_RS16820	COG1218	3'(2'),5'-bisphosphate nucleotidase
G3A50_RS16825	COG0175	sulfate reduction
G3A50_RS16835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3A50_RS16885	COG2855	membrane
G3A50_RS16890	COG0583	DNA-binding transcription factor activity
G3A50_RS16895	COG1136	(ABC) transporter
G3A50_RS16920	COG2205	protein histidine kinase activity
G3A50_RS16945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3A50_RS16945	COG3453	Protein conserved in bacteria
G3A50_RS16950	COG0640	Transcriptional regulator
G3A50_RS16970	COG4988	ABC transporter
G3A50_RS16975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G3A50_RS16985	COG1294	oxidase, subunit
G3A50_RS17000	COG1309	transcriptional regulator
G3A50_RS17010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G3A50_RS17015	COG0402	S-adenosylhomocysteine deaminase activity
G3A50_RS17025	COG0402	S-adenosylhomocysteine deaminase activity
G3A50_RS17030	COG3842	ATPase activity
G3A50_RS17040	COG4149	molybdate abc transporter
G3A50_RS17050	COG1802	Transcriptional regulator
G3A50_RS17060	COG4166	transmembrane transport
G3A50_RS17075	COG0444	Belongs to the ABC transporter superfamily
G3A50_RS17080	COG4608	Belongs to the ABC transporter superfamily
G3A50_RS17085	COG0402	S-adenosylhomocysteine deaminase activity
G3A50_RS17105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3A50_RS17110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3A50_RS17125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G3A50_RS17130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3A50_RS17140	COG1063	alcohol dehydrogenase
G3A50_RS17165	COG1175	transmembrane transport
G3A50_RS17180	COG0483	inositol monophosphate 1-phosphatase activity
G3A50_RS17190	COG0346	lactoylglutathione lyase activity
G3A50_RS17200	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G3A50_RS17205	COG0477	Major facilitator Superfamily
G3A50_RS17220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3A50_RS17220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G3A50_RS17225	COG0519	Catalyzes the synthesis of GMP from XMP
G3A50_RS17225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3A50_RS17255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3A50_RS17270	COG2948	multi-organism process
G3A50_RS17285	COG3846	protein secretion by the type IV secretion system
G3A50_RS17300	COG3451	type IV secretory pathway VirB4
G3A50_RS17315	COG4962	Type ii secretion system protein e
G3A50_RS17345	COG0583	DNA-binding transcription factor activity
G3A50_RS17385	COG1196	nuclear chromosome segregation
G3A50_RS17385	COG0741	lytic transglycosylase activity
G3A50_RS17385	COG0739	heme binding
G3A50_RS17410	COG1192	Involved in chromosome partitioning
G3A50_RS17440	COG5489	Protein of unknown function (DUF736)
G3A50_RS17450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3A50_RS17505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G3A50_RS17525	COG0464	growth
G3A50_RS17590	COG1063	alcohol dehydrogenase
G3A50_RS17660	COG1131	(ABC) transporter
G3A50_RS17695	COG1116	anion transmembrane transporter activity
G3A50_RS17700	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
G3A50_RS17710	COG5002	protein histidine kinase activity
G3A50_RS17725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G3A50_RS17730	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
G3A50_RS17735	COG0535	radical SAM domain protein
G3A50_RS17740	COG0535	radical SAM domain protein
G3A50_RS17760	COG0786	glutamate:sodium symporter activity
G3A50_RS17770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3A50_RS17775	COG0778	Nitroreductase
G3A50_RS17775	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G3A50_RS17780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G3A50_RS17785	COG1920	GTP binding
G3A50_RS17790	COG0596	Alpha beta hydrolase
G3A50_RS17800	COG3842	ATPase activity
G3A50_RS17840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G3A50_RS17870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3A50_RS17875	COG0481	GTPase activity
G3A50_RS17880	COG3422	double-strand break repair
G3A50_RS17895	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
G3A50_RS17915	COG1914	H( )-stimulated, divalent metal cation uptake system
G3A50_RS17925	COG5002	protein histidine kinase activity
G3A50_RS17925	COG3447	MASE1 domain protein
G3A50_RS17925	COG5001	Diguanylate cyclase
G3A50_RS17930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3A50_RS17935	COG1309	transcriptional regulator
G3A50_RS17950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3A50_RS17960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3A50_RS17965	COG0512	Glutamine amidotransferase of anthranilate synthase
G3A50_RS18010	COG1902	pentaerythritol trinitrate reductase activity
G3A50_RS18015	COG1846	Transcriptional regulator
G3A50_RS18020	COG1566	PFAM secretion protein HlyD family protein
G3A50_RS18025	COG2814	Major facilitator Superfamily
G3A50_RS18030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G3A50_RS18040	COG0673	inositol 2-dehydrogenase activity
G3A50_RS18050	COG0728	peptidoglycan biosynthetic process
G3A50_RS18055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3A50_RS18065	COG1396	sequence-specific DNA binding
G3A50_RS18075	COG0438	transferase activity, transferring glycosyl groups
G3A50_RS18095	COG3909	cytochrome
G3A50_RS18105	COG0697	spore germination
G3A50_RS18115	COG0351	phosphomethylpyrimidine kinase
G3A50_RS18120	COG2814	Major facilitator Superfamily
G3A50_RS18125	COG4948	Mandelate Racemase Muconate Lactonizing
G3A50_RS18130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3A50_RS18135	COG1127	ABC transporter
G3A50_RS18155	COG0633	Ferredoxin
G3A50_RS18160	COG3768	UPF0283 membrane protein
G3A50_RS18165	COG3106	COG3106 Predicted ATPase
G3A50_RS18175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS18175	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G3A50_RS18205	COG0033	Phosphoglucomutase
G3A50_RS18210	COG1846	Transcriptional regulator
G3A50_RS18235	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS18285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3A50_RS18290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3A50_RS18300	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G3A50_RS18315	COG1832	CoA-binding protein
G3A50_RS18325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G3A50_RS18330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G3A50_RS18335	COG3706	GGDEF domain
G3A50_RS18340	COG0174	glutamine synthetase
G3A50_RS18345	COG0347	Belongs to the P(II) protein family
G3A50_RS18350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G3A50_RS18350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G3A50_RS18360	COG0544	peptidyl-prolyl cis-trans isomerase activity
G3A50_RS18365	COG0740	serine-type endopeptidase activity
G3A50_RS18370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G3A50_RS18375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3A50_RS18380	COG0776	regulation of translation
G3A50_RS18390	COG0546	phosphoglycolate phosphatase activity
G3A50_RS18410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G3A50_RS18425	COG3206	protein involved in exopolysaccharide biosynthesis
G3A50_RS18425	COG0489	protein tyrosine kinase activity
G3A50_RS18435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G3A50_RS18455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS18465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS18475	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G3A50_RS18480	COG2943	transferase activity, transferring hexosyl groups
G3A50_RS18485	COG0251	oxidation-reduction process
G3A50_RS18495	COG1228	amidohydrolase
G3A50_RS18510	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G3A50_RS18520	COG0765	amino acid transport
G3A50_RS18530	COG1126	abc transporter atp-binding protein
G3A50_RS18535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS18555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3A50_RS18560	COG0318	PFAM AMP-dependent synthetase and ligase
G3A50_RS18570	COG1802	Transcriptional regulator
G3A50_RS18575	COG0488	(ABC) transporter
G3A50_RS18580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS18585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS18595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3A50_RS18600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3A50_RS18605	COG0583	DNA-binding transcription factor activity
G3A50_RS18615	COG1278	Cold shock
G3A50_RS18630	COG3459	Glycosyltransferase 36 associated
G3A50_RS18635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G3A50_RS18640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G3A50_RS18645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3A50_RS18650	COG0538	isocitrate dehydrogenase activity
G3A50_RS18655	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
G3A50_RS18670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G3A50_RS18675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G3A50_RS18685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G3A50_RS18690	COG0047	phosphoribosylformylglycinamidine synthase activity
G3A50_RS18695	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G3A50_RS18700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G3A50_RS18720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G3A50_RS18740	COG3191	aminopeptidase activity
G3A50_RS18745	COG0785	Cytochrome C biogenesis protein
G3A50_RS18750	COG0683	leucine binding
G3A50_RS18780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3A50_RS18785	COG2081	HI0933 family
G3A50_RS18790	COG1509	lysine 2,3-aminomutase activity
G3A50_RS18800	COG3608	succinylglutamate desuccinylase aspartoacylase
G3A50_RS18800	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G3A50_RS18820	COG0154	amidase activity
G3A50_RS18835	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3A50_RS18845	COG1309	transcriptional regulator
G3A50_RS18855	COG1131	(ABC) transporter
G3A50_RS18865	COG0477	Major facilitator Superfamily
G3A50_RS18870	COG0459	protein refolding
G3A50_RS18875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G3A50_RS18880	COG5425	PFAM Usg family protein
G3A50_RS18885	COG3932	Exopolysaccharide synthesis, ExoD
G3A50_RS18890	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS18900	COG1305	Transglutaminase-like
G3A50_RS18910	COG1280	lysine exporter protein (LysE YggA)
G3A50_RS18915	COG2308	Evidence 4 Homologs of previously reported genes of
G3A50_RS18920	COG1546	Belongs to the CinA family
G3A50_RS18920	COG1058	Belongs to the CinA family
G3A50_RS18925	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G3A50_RS18960	COG1289	transmembrane transporter activity
G3A50_RS18980	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
G3A50_RS18985	COG0076	glutamate decarboxylase activity
G3A50_RS18990	COG4771	TonB-dependent receptor
G3A50_RS19000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G3A50_RS19005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3A50_RS19010	COG4558	Periplasmic binding protein
G3A50_RS19015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS19020	COG1116	anion transmembrane transporter activity
G3A50_RS19025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3A50_RS19030	COG0405	Gamma-glutamyltransferase
G3A50_RS19035	COG1473	amidohydrolase
G3A50_RS19050	COG2368	4-hydroxyphenylacetate
G3A50_RS19060	COG2368	4-hydroxyphenylacetate
G3A50_RS19065	COG3608	succinylglutamate desuccinylase aspartoacylase
G3A50_RS19095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3A50_RS19100	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS19105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3A50_RS19105	COG0475	glutathione-regulated potassium exporter activity
G3A50_RS19125	COG0783	Belongs to the Dps family
G3A50_RS19140	COG4566	intracellular signal transduction
G3A50_RS19145	COG4191	Histidine kinase
G3A50_RS19160	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3A50_RS19160	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3A50_RS19160	COG0506	proline dehydrogenase activity
G3A50_RS19165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3A50_RS19235	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G3A50_RS19240	COG0302	gtp cyclohydrolase
G3A50_RS19260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G3A50_RS19280	COG0784	Response regulator, receiver
G3A50_RS19280	COG5002	protein histidine kinase activity
G3A50_RS19280	COG2205	protein histidine kinase activity
G3A50_RS19315	COG1132	(ABC) transporter
G3A50_RS19325	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3A50_RS19345	COG0525	valine-tRNA ligase activity
G3A50_RS19360	COG0129	dihydroxy-acid dehydratase activity
G3A50_RS19385	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G3A50_RS19390	COG0018	arginyl-trna synthetase
G3A50_RS19400	COG1472	Belongs to the glycosyl hydrolase 3 family
G3A50_RS19405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G3A50_RS19410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G3A50_RS19415	COG3842	ATPase activity
G3A50_RS19420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3A50_RS19425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3A50_RS19430	COG0805	protein transport
G3A50_RS19435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G3A50_RS19440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G3A50_RS19445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3A50_RS19460	COG1862	Preprotein translocase
G3A50_RS19465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G3A50_RS19470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G3A50_RS19485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3A50_RS19495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G3A50_RS19505	COG0662	Cupin 2, conserved barrel domain protein
G3A50_RS19505	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G3A50_RS19510	COG0628	permease
G3A50_RS19525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3A50_RS19530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3A50_RS19535	COG0649	NAD binding
G3A50_RS19540	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G3A50_RS19545	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G3A50_RS19560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G3A50_RS19570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3A50_RS19580	COG0713	ATP synthesis coupled electron transport
G3A50_RS19595	COG1007	ATP synthesis coupled electron transport
G3A50_RS19610	COG0346	lactoylglutathione lyase activity
G3A50_RS19620	COG0442	prolyl-tRNA aminoacylation
G3A50_RS19630	COG1136	(ABC) transporter
G3A50_RS19645	COG0052	Belongs to the universal ribosomal protein uS2 family
G3A50_RS19650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G3A50_RS19655	COG0528	UMP kinase activity
G3A50_RS19660	COG0233	cytoplasmic translational termination
G3A50_RS19665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G3A50_RS19675	COG0750	zinc metalloprotease
G3A50_RS19680	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3A50_RS19685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3A50_RS19690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3A50_RS19695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3A50_RS19700	COG3494	Protein of unknown function (DUF1009)
G3A50_RS19705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3A50_RS19710	COG0372	Belongs to the citrate synthase family
G3A50_RS19715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3A50_RS19725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G3A50_RS19735	COG1802	Transcriptional regulator
G3A50_RS19745	COG0303	'Molybdopterin
G3A50_RS19750	COG0315	cyclic pyranopterin monophosphate synthase activity
G3A50_RS19755	COG0134	indole-3-glycerol-phosphate synthase activity
G3A50_RS19760	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G3A50_RS19770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G3A50_RS19780	COG0149	triose-phosphate isomerase activity
G3A50_RS19790	COG0504	CTP synthase activity
G3A50_RS19820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G3A50_RS19825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G3A50_RS19830	COG0148	phosphopyruvate hydratase activity
G3A50_RS19845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3A50_RS19855	COG0022	dehydrogenase e1 component
G3A50_RS19855	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3A50_RS19860	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3A50_RS19865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3A50_RS19870	COG2261	transglycosylase associated protein
G3A50_RS19875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G3A50_RS19880	COG2867	negative regulation of translational initiation
G3A50_RS19885	COG1546	Belongs to the CinA family
G3A50_RS19890	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G3A50_RS19890	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G3A50_RS19905	COG2204	response regulator
G3A50_RS19910	COG5000	phosphorelay sensor kinase activity
G3A50_RS19915	COG2204	response regulator
G3A50_RS19920	COG0569	domain protein
G3A50_RS19925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G3A50_RS19930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3A50_RS19935	COG1923	regulation of RNA biosynthetic process
G3A50_RS19940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G3A50_RS19945	COG3956	TIGRFAM MazG family protein
G3A50_RS19950	COG0321	lipoyl(octanoyl) transferase activity
G3A50_RS19950	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G3A50_RS19955	COG0084	hydrolase, TatD family'
G3A50_RS19965	COG0470	DNA polymerase III
G3A50_RS19970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G3A50_RS19975	COG1686	Belongs to the peptidase S11 family
G3A50_RS19990	COG1136	(ABC) transporter
G3A50_RS20000	COG1785	Belongs to the alkaline phosphatase family
G3A50_RS20005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G3A50_RS20010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G3A50_RS20025	COG0356	it plays a direct role in the translocation of protons across the membrane
G3A50_RS20035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3A50_RS20035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3A50_RS20040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G3A50_RS20060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3A50_RS20060	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G3A50_RS20065	COG0583	DNA-binding transcription factor activity
G3A50_RS20070	COG2814	Major facilitator Superfamily
G3A50_RS20080	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS20085	COG0366	Alpha amylase catalytic
G3A50_RS20090	COG0640	Transcriptional regulator
G3A50_RS20105	COG0798	PFAM Bile acid sodium symporter
G3A50_RS20110	COG0431	NADPH-dependent FMN reductase
G3A50_RS20115	COG2197	response regulator
G3A50_RS20135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3A50_RS20150	COG0714	Associated with various cellular activities
G3A50_RS20195	COG3938	Belongs to the proline racemase family
G3A50_RS20200	COG1177	transmembrane transport
G3A50_RS20220	COG2169	Transcriptional regulator
G3A50_RS20220	COG1917	Cupin 2, conserved barrel domain protein
G3A50_RS20230	COG0300	oxidoreductase activity
G3A50_RS20235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3A50_RS20245	COG2205	protein histidine kinase activity
G3A50_RS20250	COG0745	RESPONSE REGULATOR receiver
G3A50_RS20260	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3A50_RS20480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3A50_RS20490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3A50_RS20510	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS20525	COG1183	phosphatidylcholine synthase activity
G3A50_RS20530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3A50_RS20535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G3A50_RS20535	COG0546	phosphoglycolate phosphatase activity
G3A50_RS20570	COG0679	Auxin Efflux Carrier
G3A50_RS20585	COG4166	transmembrane transport
G3A50_RS20595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G3A50_RS20600	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G3A50_RS20610	COG2832	Protein of unknown function (DUF454)
G3A50_RS20615	COG0746	molybdenum cofactor guanylyltransferase activity
G3A50_RS20620	COG1763	Mo-molybdopterin cofactor biosynthetic process
G3A50_RS20640	COG0477	Major facilitator Superfamily
G3A50_RS20655	COG0583	DNA-binding transcription factor activity
G3A50_RS20675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G3A50_RS20685	COG0655	NAD(P)H dehydrogenase (quinone) activity
G3A50_RS20690	COG0343	queuine tRNA-ribosyltransferase activity
G3A50_RS20695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G3A50_RS20710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G3A50_RS20720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G3A50_RS20725	COG2095	MarC family integral membrane protein
G3A50_RS20735	COG0629	single-stranded DNA binding
G3A50_RS20740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G3A50_RS20745	COG1612	heme a metabolic process
G3A50_RS20770	COG0778	Nitroreductase
G3A50_RS20775	COG1012	belongs to the aldehyde dehydrogenase family
G3A50_RS20780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G3A50_RS20790	COG0776	regulation of translation
G3A50_RS20795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G3A50_RS20800	COG0416	fatty acid biosynthetic process
G3A50_RS20820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3A50_RS20830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G3A50_RS20835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3A50_RS20840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G3A50_RS20850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3A50_RS20850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3A50_RS20855	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G3A50_RS20860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G3A50_RS20880	COG1846	Transcriptional regulator
G3A50_RS20890	COG1024	Enoyl-CoA hydratase
G3A50_RS20895	COG0113	porphobilinogen synthase activity
G3A50_RS20900	COG0559	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS20905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G3A50_RS20915	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G3A50_RS20920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G3A50_RS20930	COG1381	Involved in DNA repair and RecF pathway recombination
G3A50_RS20935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G3A50_RS20940	COG0571	ribonuclease III activity
G3A50_RS20950	COG0736	holo-[acyl-carrier-protein] synthase activity
G3A50_RS20955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G3A50_RS20960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G3A50_RS20975	COG1758	RNA polymerase activity
G3A50_RS20985	COG1573	uracil-dna glycosylase
G3A50_RS20990	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G3A50_RS20995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G3A50_RS21000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G3A50_RS21005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3A50_RS21010	COG1196	nuclear chromosome segregation
G3A50_RS21010	COG0741	lytic transglycosylase activity
G3A50_RS21010	COG0739	heme binding
G3A50_RS21070	COG0346	lactoylglutathione lyase activity
G3A50_RS21080	COG0668	transmembrane transport
G3A50_RS21085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3A50_RS21100	COG4753	response regulator
G3A50_RS21100	COG2207	Transcriptional regulator
G3A50_RS21110	COG0154	amidase activity
G3A50_RS21115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3A50_RS21120	COG1028	Short-chain dehydrogenase reductase Sdr
G3A50_RS21125	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G3A50_RS21135	COG1879	ABC-type sugar transport system periplasmic component
G3A50_RS21140	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS21150	COG1129	ABC transporter
G3A50_RS21155	COG0583	DNA-binding transcription factor activity
G3A50_RS21170	COG0765	amino acid transport
G3A50_RS21190	COG1012	belongs to the aldehyde dehydrogenase family
G3A50_RS21275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3A50_RS21280	COG0601	transmembrane transport
G3A50_RS21285	COG4166	transmembrane transport
G3A50_RS21290	COG4172	Belongs to the ABC transporter superfamily
G3A50_RS21305	COG1132	(ABC) transporter
G3A50_RS21305	COG1132	(ABC) transporter
G3A50_RS21320	COG4302	ethanolamine ammonia-lyase activity
G3A50_RS21325	COG4303	Ethanolamine ammonia lyase large subunit
G3A50_RS21335	COG5001	Diguanylate cyclase
G3A50_RS21335	COG3300	MHYT domain
G3A50_RS21345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3A50_RS21360	COG0477	Major facilitator Superfamily
G3A50_RS21365	COG2186	Transcriptional regulator
G3A50_RS21375	COG0765	amino acid transport
G3A50_RS21395	COG3842	ATPase activity
G3A50_RS21400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3A50_RS21405	COG1177	transmembrane transport
G3A50_RS21440	COG2204	response regulator
G3A50_RS21440	COG5564	TIM-barrel signal transduction protein
G3A50_RS21445	COG1609	Transcriptional regulator
G3A50_RS21455	COG0673	inositol 2-dehydrogenase activity
G3A50_RS21460	COG1129	ABC transporter
G3A50_RS21465	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3A50_RS21470	COG1879	ABC-type sugar transport system periplasmic component
G3A50_RS21480	COG1175	transmembrane transport
G3A50_RS21485	COG0395	ABC-type sugar transport system, permease component
G3A50_RS21500	COG3842	ATPase activity
G3A50_RS21510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G3A50_RS21515	COG0829	nickel cation binding
G3A50_RS21525	COG0830	nickel cation binding
G3A50_RS21555	COG3842	ATPase activity
G3A50_RS21565	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3A50_RS21595	COG0583	DNA-binding transcription factor activity
G3A50_RS21605	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G3A50_RS21620	COG4521	taurine ABC transporter
G3A50_RS21625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G3A50_RS21630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3A50_RS21635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3A50_RS21640	COG2336	PFAM SpoVT AbrB
G3A50_RS21645	COG2337	Toxic component of a toxin-antitoxin (TA) module
G3A50_RS21650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G3A50_RS21655	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
G3A50_RS21660	COG2948	multi-organism process
G3A50_RS21665	COG3504	Conjugal transfer protein
G3A50_RS21670	COG3736	Type IV secretory pathway, component VirB8
G3A50_RS21680	COG3704	protein secretion by the type IV secretion system
G3A50_RS21695	COG3451	type IV secretory pathway VirB4
G3A50_RS21700	COG3702	type iv secretory pathway
G3A50_RS21725	COG1414	Transcriptional regulator
G3A50_RS21735	COG1525	nuclease
G3A50_RS21750	COG1192	Involved in chromosome partitioning
G3A50_RS21755	COG1475	DNA binding
G3A50_RS21760	COG1414	Transcriptional regulator
G3A50_RS21795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G3A50_RS21825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3A50_RS21850	COG1695	Transcriptional regulator
G3A50_RS21860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3A50_RS21865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3A50_RS21915	COG1959	2 iron, 2 sulfur cluster binding
G3A50_RS21940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G3A50_RS21945	COG0066	3-isopropylmalate dehydratase activity
G3A50_RS21960	COG2059	Chromate
G3A50_RS21975	COG1238	metal cluster binding
G3A50_RS21980	COG2814	Major facilitator Superfamily
G3A50_RS21990	COG1937	Protein conserved in bacteria
G3A50_RS22080	COG4964	Belongs to the GSP D family
G3A50_RS22090	COG2894	cell division
G3A50_RS22185	COG0629	single-stranded DNA binding
G3A50_RS22220	COG3505	Type IV secretory pathway VirD4
G3A50_RS22235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G3A50_RS22250	COG4974	Belongs to the 'phage' integrase family
G3A50_RS22345	COG1129	ABC transporter
G3A50_RS22350	COG0832	Belongs to the urease beta subunit family
G3A50_RS22350	COG0831	urea catabolic process
G3A50_RS22355	COG0804	urea catabolic process