locus-tag	class	description
GBB76_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GBB76_RS00010	COG0268	Binds directly to 16S ribosomal RNA
GBB76_RS00015	COG1024	Enoyl-CoA hydratase
GBB76_RS00020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GBB76_RS00035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GBB76_RS00040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GBB76_RS00045	COG0109	protoheme IX farnesyltransferase activity
GBB76_RS00055	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GBB76_RS00070	COG3346	SURF1 family
GBB76_RS00080	COG0612	Peptidase, M16
GBB76_RS00085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GBB76_RS00100	COG1840	ABC-type Fe3 transport system, periplasmic component
GBB76_RS00110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GBB76_RS00120	COG1238	metal cluster binding
GBB76_RS00140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GBB76_RS00145	COG0459	protein refolding
GBB76_RS00150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GBB76_RS00155	COG1294	oxidase, subunit
GBB76_RS00160	COG1271	oxidase subunit
GBB76_RS00165	COG1573	uracil-dna glycosylase
GBB76_RS00195	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GBB76_RS00200	COG3639	organic phosphonate transmembrane transporter activity
GBB76_RS00205	COG4178	(ABC) transporter
GBB76_RS00215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GBB76_RS00220	COG3214	Protein conserved in bacteria
GBB76_RS00225	COG5001	Diguanylate cyclase
GBB76_RS00230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBB76_RS00240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GBB76_RS00255	COG3258	Cytochrome c
GBB76_RS00280	COG0730	response to heat
GBB76_RS00295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GBB76_RS00305	COG1703	isobutyryl-CoA mutase activity
GBB76_RS00310	COG3237	CsbD-like
GBB76_RS00315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GBB76_RS00320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GBB76_RS00325	COG0433	COG0433 Predicted ATPase
GBB76_RS00330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GBB76_RS00335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GBB76_RS00355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GBB76_RS00370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GBB76_RS00395	COG2166	iron-sulfur cluster assembly
GBB76_RS00435	COG2983	Belongs to the UPF0260 family
GBB76_RS00445	COG1304	FMN binding
GBB76_RS00450	COG1620	l-lactate permease
GBB76_RS00470	COG0717	Belongs to the dCTP deaminase family
GBB76_RS00475	COG0431	NADPH-dependent FMN reductase
GBB76_RS00500	COG4695	Portal protein
GBB76_RS00540	COG5640	endopeptidase activity
GBB76_RS00645	COG4235	cytochrome complex assembly
GBB76_RS00650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GBB76_RS00655	COG1138	Cytochrome C-type biogenesis protein
GBB76_RS00670	COG3088	subunit of a heme lyase
GBB76_RS00675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GBB76_RS00680	COG0745	RESPONSE REGULATOR receiver
GBB76_RS00690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GBB76_RS00695	COG0579	oxidoreductase
GBB76_RS00700	COG2205	protein histidine kinase activity
GBB76_RS00700	COG2202	Pas domain
GBB76_RS00705	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
GBB76_RS00710	COG4251	negative regulation of phosphorylation
GBB76_RS00710	COG5001	Diguanylate cyclase
GBB76_RS00710	COG3706	GGDEF domain
GBB76_RS00710	COG2203	Gaf domain
GBB76_RS00715	COG0308	aminopeptidase N
GBB76_RS00735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GBB76_RS00745	COG0189	ligase activity
GBB76_RS00760	COG0702	epimerase
GBB76_RS00770	COG2154	pterin-4-alpha-carbinolamine dehydratase
GBB76_RS00780	COG1229	Formylmethanofuran dehydrogenase subunit A
GBB76_RS00785	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
GBB76_RS00790	COG2218	PFAM glutamate synthase alpha subunit domain protein
GBB76_RS00795	COG2239	Acts as a magnesium transporter
GBB76_RS00830	COG0488	(ABC) transporter
GBB76_RS00845	COG0277	FAD linked oxidase domain protein
GBB76_RS00855	COG0848	biopolymer transport protein
GBB76_RS00865	COG4608	Belongs to the ABC transporter superfamily
GBB76_RS00870	COG0444	Belongs to the ABC transporter superfamily
GBB76_RS00875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GBB76_RS00880	COG0601	transmembrane transport
GBB76_RS00885	COG0747	negative chemotaxis
GBB76_RS00895	COG1803	Methylglyoxal synthase
GBB76_RS00900	COG1959	2 iron, 2 sulfur cluster binding
GBB76_RS00905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GBB76_RS00920	COG1285	pathogenesis
GBB76_RS00945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GBB76_RS00950	COG2224	Isocitrate lyase
GBB76_RS00960	COG3800	Transcriptional regulator
GBB76_RS00960	COG1396	sequence-specific DNA binding
GBB76_RS00970	COG0625	glutathione transferase activity
GBB76_RS00975	COG2079	MmgE PrpD family protein
GBB76_RS00980	COG0473	3-isopropylmalate dehydrogenase activity
GBB76_RS00990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GBB76_RS00995	COG2186	Transcriptional regulator
GBB76_RS01000	COG0473	3-isopropylmalate dehydrogenase activity
GBB76_RS01040	COG0596	Alpha beta hydrolase
GBB76_RS01065	COG4176	ABC-type proline glycine betaine transport system permease component
GBB76_RS01070	COG3448	diguanylate cyclase activity
GBB76_RS01070	COG4175	Glycine betaine
GBB76_RS01075	COG2113	Glycine betaine
GBB76_RS01085	COG2188	Transcriptional regulator
GBB76_RS01090	COG3454	Phosphonate metabolism
GBB76_RS01100	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GBB76_RS01110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GBB76_RS01115	COG0730	response to heat
GBB76_RS01130	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GBB76_RS01135	COG0778	Nitroreductase
GBB76_RS01140	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GBB76_RS01145	COG1525	nuclease
GBB76_RS01165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBB76_RS01175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GBB76_RS01180	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GBB76_RS01185	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GBB76_RS01200	COG2814	Major facilitator Superfamily
GBB76_RS01215	COG2755	lipolytic protein G-D-S-L family
GBB76_RS01215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GBB76_RS01220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GBB76_RS01220	COG2755	lipolytic protein G-D-S-L family
GBB76_RS01225	COG2755	lipolytic protein G-D-S-L family
GBB76_RS01225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GBB76_RS01230	COG1376	ErfK ybiS ycfS ynhG family protein
GBB76_RS01245	COG0546	phosphoglycolate phosphatase activity
GBB76_RS01255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GBB76_RS01275	COG3181	Tripartite tricarboxylate transporter family receptor
GBB76_RS01285	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GBB76_RS01310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GBB76_RS01310	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GBB76_RS01320	COG3045	CreA protein
GBB76_RS01330	COG0215	cysteine-tRNA ligase activity
GBB76_RS01350	COG5265	(ABC) transporter
GBB76_RS01355	COG0688	phosphatidylethanolamine metabolic process
GBB76_RS01360	COG1183	phosphatidylcholine synthase activity
GBB76_RS01375	COG4221	oxidoreductase activity
GBB76_RS01415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GBB76_RS01425	COG0174	glutamine synthetase
GBB76_RS01445	COG1560	Kdo2-lipid A biosynthetic process
GBB76_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS01460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GBB76_RS01470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GBB76_RS01475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBB76_RS01485	COG4953	penicillin-binding protein 1C
GBB76_RS01505	COG1216	Glycosyl transferase, family 2
GBB76_RS01505	COG0463	Glycosyl transferase, family 2
GBB76_RS01510	COG0297	glycogen (starch) synthase activity
GBB76_RS01540	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GBB76_RS01545	COG0477	Major facilitator Superfamily
GBB76_RS01560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GBB76_RS01560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GBB76_RS01565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GBB76_RS01565	COG0519	Catalyzes the synthesis of GMP from XMP
GBB76_RS01570	COG2207	Transcriptional regulator
GBB76_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS01585	COG0667	Aldo Keto reductase
GBB76_RS01600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GBB76_RS01605	COG0500	methyltransferase
GBB76_RS01615	COG4191	Histidine kinase
GBB76_RS01615	COG0784	Response regulator, receiver
GBB76_RS01640	COG4106	trans-aconitate 2-methyltransferase activity
GBB76_RS01650	COG0640	Transcriptional regulator
GBB76_RS01655	COG0288	reversible hydration of carbon dioxide
GBB76_RS01710	COG1131	(ABC) transporter
GBB76_RS01745	COG1116	anion transmembrane transporter activity
GBB76_RS01750	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
GBB76_RS01760	COG5002	protein histidine kinase activity
GBB76_RS01780	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GBB76_RS01785	COG0535	radical SAM domain protein
GBB76_RS01790	COG0535	radical SAM domain protein
GBB76_RS01820	COG1393	Belongs to the ArsC family
GBB76_RS01830	COG5002	protein histidine kinase activity
GBB76_RS01830	COG5001	Diguanylate cyclase
GBB76_RS01830	COG3447	MASE1 domain protein
GBB76_RS01845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GBB76_RS01860	COG1160	GTP binding
GBB76_RS01870	COG0300	oxidoreductase activity
GBB76_RS01880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GBB76_RS01885	COG1286	toxin biosynthetic process
GBB76_RS01895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GBB76_RS01900	COG0305	Participates in initiation and elongation during chromosome replication
GBB76_RS01905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GBB76_RS01910	COG0359	binds to the 23S rRNA
GBB76_RS01920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GBB76_RS01925	COG0360	Binds together with S18 to 16S ribosomal RNA
GBB76_RS01935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GBB76_RS01945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBB76_RS01950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GBB76_RS01955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GBB76_RS01960	COG1561	YicC-like family, N-terminal region
GBB76_RS01965	COG0194	GDP metabolic process
GBB76_RS01970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GBB76_RS01975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GBB76_RS01985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GBB76_RS02000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GBB76_RS02015	COG0488	(ABC) transporter
GBB76_RS02035	COG0105	UTP biosynthetic process
GBB76_RS02040	COG0861	Integral membrane protein TerC family
GBB76_RS02045	COG0861	Integral membrane protein TerC family
GBB76_RS02050	COG0243	molybdopterin cofactor binding
GBB76_RS02065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GBB76_RS02070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GBB76_RS02075	COG3135	benzoate transporter
GBB76_RS02080	COG0628	permease
GBB76_RS02090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GBB76_RS02095	COG0248	Ppx GppA phosphatase
GBB76_RS02100	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GBB76_RS02110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GBB76_RS02120	COG0280	phosphate acetyltransferase
GBB76_RS02120	COG0281	malic enzyme
GBB76_RS02135	COG1278	Cold shock
GBB76_RS02140	COG1278	Cold shock
GBB76_RS02145	COG0519	Catalyzes the synthesis of GMP from XMP
GBB76_RS02155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GBB76_RS02160	COG2814	Major facilitator Superfamily
GBB76_RS02180	COG0439	Biotin carboxylase
GBB76_RS02185	COG0511	ligase activity, forming carbon-carbon bonds
GBB76_RS02190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GBB76_RS02205	COG0436	Aminotransferase
GBB76_RS02215	COG0702	epimerase
GBB76_RS02220	COG1530	ribonuclease E activity
GBB76_RS02225	COG0860	N-Acetylmuramoyl-L-alanine amidase
GBB76_RS02245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GBB76_RS02255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GBB76_RS02260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GBB76_RS02270	COG2945	thiolester hydrolase activity
GBB76_RS02280	COG0719	Fe-S assembly protein
GBB76_RS02285	COG0396	ATPase activity
GBB76_RS02290	COG0719	Fe-S assembly protein
GBB76_RS02295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GBB76_RS02300	COG2151	metal-sulfur cluster biosynthetic enzyme
GBB76_RS02310	COG0316	Belongs to the HesB IscA family
GBB76_RS02320	COG0668	transmembrane transport
GBB76_RS02325	COG0513	Belongs to the DEAD box helicase family
GBB76_RS02330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GBB76_RS02335	COG1280	lysine exporter protein (LysE YggA)
GBB76_RS02345	COG0187	DNA topoisomerase II activity
GBB76_RS02350	COG0463	Glycosyl transferase, family 2
GBB76_RS02360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GBB76_RS02365	COG3243	poly(R)-hydroxyalkanoic acid synthase
GBB76_RS02385	COG0436	Aminotransferase
GBB76_RS02395	COG1494	fructose-1,6-bisphosphatase
GBB76_RS02425	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GBB76_RS02425	COG0493	'glutamate synthase
GBB76_RS02495	COG0829	nickel cation binding
GBB76_RS02500	COG0832	Belongs to the urease beta subunit family
GBB76_RS02500	COG0831	urea catabolic process
GBB76_RS02505	COG0804	urea catabolic process
GBB76_RS02510	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GBB76_RS02515	COG0830	nickel cation binding
GBB76_RS02520	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GBB76_RS02525	COG5001	Diguanylate cyclase
GBB76_RS02525	COG3300	MHYT domain
GBB76_RS02530	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GBB76_RS02535	COG0626	cystathionine gamma-synthase activity
GBB76_RS02540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBB76_RS02545	COG4597	amino acid ABC transporter
GBB76_RS02550	COG0765	amino acid transport
GBB76_RS02555	COG1126	abc transporter atp-binding protein
GBB76_RS02560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GBB76_RS02565	COG2897	thiosulfate sulfurtransferase activity
GBB76_RS02570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GBB76_RS02575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GBB76_RS02580	COG0415	Belongs to the DNA photolyase family
GBB76_RS02590	COG0729	surface antigen
GBB76_RS02595	COG1192	Involved in chromosome partitioning
GBB76_RS02600	COG1388	LysM domain
GBB76_RS02600	COG1376	ErfK ybiS ycfS ynhG family protein
GBB76_RS02615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GBB76_RS02635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GBB76_RS02640	COG1324	tolerance protein
GBB76_RS02660	COG1177	transmembrane transport
GBB76_RS02670	COG3842	ATPase activity
GBB76_RS02675	COG1840	ABC-type Fe3 transport system, periplasmic component
GBB76_RS02680	COG1253	flavin adenine dinucleotide binding
GBB76_RS02685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GBB76_RS02710	COG0251	oxidation-reduction process
GBB76_RS02720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GBB76_RS02735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GBB76_RS02745	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GBB76_RS02755	COG0693	protein deglycase activity
GBB76_RS02765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GBB76_RS02770	COG0081	regulation of translation
GBB76_RS02775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GBB76_RS02780	COG0222	ribosome binding
GBB76_RS02785	COG0085	RNA polymerase activity
GBB76_RS02790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GBB76_RS02795	COG1764	response to oxidative stress
GBB76_RS02800	COG1846	Transcriptional regulator
GBB76_RS02805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GBB76_RS02810	COG0049	tRNA binding
GBB76_RS02815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GBB76_RS02820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GBB76_RS02825	COG0051	transcription antitermination factor activity, RNA binding
GBB76_RS02830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GBB76_RS02835	COG0088	Forms part of the polypeptide exit tunnel
GBB76_RS02840	COG0089	rRNA binding
GBB76_RS02845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GBB76_RS02850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GBB76_RS02860	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GBB76_RS02865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GBB76_RS02870	COG0255	Belongs to the universal ribosomal protein uL29 family
GBB76_RS02875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GBB76_RS02880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GBB76_RS02885	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GBB76_RS02890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GBB76_RS02895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GBB76_RS02900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GBB76_RS02905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GBB76_RS02910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GBB76_RS02915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GBB76_RS02920	COG1841	ribosomal large subunit assembly
GBB76_RS02925	COG0200	Binds to the 23S rRNA
GBB76_RS02930	COG0201	protein transport
GBB76_RS02935	COG0563	adenylate kinase activity
GBB76_RS02940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GBB76_RS02945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GBB76_RS02950	COG0202	RNA polymerase activity
GBB76_RS02955	COG0203	ribosomal protein L17
GBB76_RS02965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GBB76_RS02970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GBB76_RS02975	COG0564	pseudouridine synthase activity
GBB76_RS02990	COG0321	lipoyl(octanoyl) transferase activity
GBB76_RS02995	COG1254	Belongs to the acylphosphatase family
GBB76_RS03000	COG2239	Acts as a magnesium transporter
GBB76_RS03005	COG3300	MHYT domain
GBB76_RS03005	COG5001	Diguanylate cyclase
GBB76_RS03010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GBB76_RS03035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GBB76_RS03045	COG0484	heat shock protein binding
GBB76_RS03050	COG1686	Belongs to the peptidase S11 family
GBB76_RS03060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GBB76_RS03080	COG0537	adenosine 5'-monophosphoramidase activity
GBB76_RS03105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GBB76_RS03115	COG0784	Response regulator, receiver
GBB76_RS03120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GBB76_RS03140	COG0557	exoribonuclease II activity
GBB76_RS03145	COG0477	Major facilitator Superfamily
GBB76_RS03150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GBB76_RS03160	COG0758	DNA mediated transformation
GBB76_RS03165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GBB76_RS03175	COG0540	Belongs to the ATCase OTCase family
GBB76_RS03185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GBB76_RS03190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GBB76_RS03215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GBB76_RS03220	COG0154	amidase activity
GBB76_RS03225	COG1605	Chorismate mutase
GBB76_RS03225	COG0287	Prephenate dehydrogenase
GBB76_RS03235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GBB76_RS03250	COG0625	glutathione transferase activity
GBB76_RS03260	COG0028	Belongs to the TPP enzyme family
GBB76_RS03270	COG0281	malic enzyme
GBB76_RS03275	COG0114	fumarate hydratase activity
GBB76_RS03285	COG0583	DNA-binding transcription factor activity
GBB76_RS03290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GBB76_RS03300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GBB76_RS03320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GBB76_RS03335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GBB76_RS03345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GBB76_RS03350	COG2205	protein histidine kinase activity
GBB76_RS03355	COG0745	RESPONSE REGULATOR receiver
GBB76_RS03360	COG0477	Major facilitator Superfamily
GBB76_RS03370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GBB76_RS03385	COG4303	Ethanolamine ammonia lyase large subunit
GBB76_RS03400	COG3034	peptidoglycan biosynthetic process
GBB76_RS03405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GBB76_RS03415	COG1401	restriction endodeoxyribonuclease activity
GBB76_RS03415	COG1401	restriction endodeoxyribonuclease activity
GBB76_RS03425	COG0270	DNA (cytosine-5-)-methyltransferase activity
GBB76_RS03490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GBB76_RS03530	COG0427	acetyl-CoA hydrolase
GBB76_RS03555	COG1196	nuclear chromosome segregation
GBB76_RS03555	COG0739	heme binding
GBB76_RS03555	COG0741	lytic transglycosylase activity
GBB76_RS03560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GBB76_RS03565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GBB76_RS03570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GBB76_RS03580	COG1573	uracil-dna glycosylase
GBB76_RS03590	COG1758	RNA polymerase activity
GBB76_RS03605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GBB76_RS03610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GBB76_RS03615	COG0736	holo-[acyl-carrier-protein] synthase activity
GBB76_RS03625	COG0571	ribonuclease III activity
GBB76_RS03635	COG1381	Involved in DNA repair and RecF pathway recombination
GBB76_RS03645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GBB76_RS03655	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GBB76_RS03665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GBB76_RS03675	COG0113	porphobilinogen synthase activity
GBB76_RS03685	COG1024	Enoyl-CoA hydratase
GBB76_RS03695	COG1846	Transcriptional regulator
GBB76_RS03705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GBB76_RS03715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GBB76_RS03715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GBB76_RS03725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GBB76_RS03730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GBB76_RS03735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GBB76_RS03765	COG0416	fatty acid biosynthetic process
GBB76_RS03770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GBB76_RS03775	COG0776	regulation of translation
GBB76_RS03785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GBB76_RS03790	COG1012	belongs to the aldehyde dehydrogenase family
GBB76_RS03795	COG0778	Nitroreductase
GBB76_RS03820	COG1612	heme a metabolic process
GBB76_RS03825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GBB76_RS03830	COG0629	single-stranded DNA binding
GBB76_RS03840	COG2095	MarC family integral membrane protein
GBB76_RS03845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GBB76_RS03855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GBB76_RS03870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GBB76_RS03875	COG0343	queuine tRNA-ribosyltransferase activity
GBB76_RS03880	COG0655	NAD(P)H dehydrogenase (quinone) activity
GBB76_RS03895	COG2203	Gaf domain
GBB76_RS03895	COG2200	EAL domain
GBB76_RS03895	COG2199	diguanylate cyclase activity
GBB76_RS03915	COG1763	Mo-molybdopterin cofactor biosynthetic process
GBB76_RS03920	COG0746	molybdenum cofactor guanylyltransferase activity
GBB76_RS03925	COG2832	Protein of unknown function (DUF454)
GBB76_RS03930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GBB76_RS03935	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GBB76_RS03940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GBB76_RS03965	COG0679	Auxin Efflux Carrier
GBB76_RS03970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GBB76_RS03975	COG1183	phosphatidylcholine synthase activity
GBB76_RS03985	COG3845	ABC transporter
GBB76_RS03990	COG4603	Belongs to the binding-protein-dependent transport system permease family
GBB76_RS04010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GBB76_RS04015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GBB76_RS04020	COG2329	Antibiotic biosynthesis monooxygenase
GBB76_RS04045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GBB76_RS04050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GBB76_RS04065	COG0789	Transcriptional regulator
GBB76_RS04070	COG0583	DNA-binding transcription factor activity
GBB76_RS04085	COG0656	L-ascorbic acid biosynthetic process
GBB76_RS04115	COG2372	response to copper ion
GBB76_RS04240	COG3750	Belongs to the UPF0335 family
GBB76_RS04275	COG4383	Mu-like prophage protein gp29
GBB76_RS04280	COG4373	Mu-like prophage FluMu protein gp28
GBB76_RS04465	COG1686	Belongs to the peptidase S11 family
GBB76_RS04470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GBB76_RS04475	COG0470	DNA polymerase III
GBB76_RS04485	COG0084	hydrolase, TatD family'
GBB76_RS04490	COG0321	lipoyl(octanoyl) transferase activity
GBB76_RS04490	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GBB76_RS04495	COG3956	TIGRFAM MazG family protein
GBB76_RS04505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GBB76_RS04510	COG1923	regulation of RNA biosynthetic process
GBB76_RS04515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GBB76_RS04525	COG0569	domain protein
GBB76_RS04530	COG2204	response regulator
GBB76_RS04535	COG5000	phosphorelay sensor kinase activity
GBB76_RS04540	COG2204	response regulator
GBB76_RS04555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GBB76_RS04555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GBB76_RS04565	COG2867	negative regulation of translational initiation
GBB76_RS04570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GBB76_RS04580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GBB76_RS04585	COG0508	dehydrogenase complex catalyzes the overall conversion of
GBB76_RS04590	COG0022	dehydrogenase e1 component
GBB76_RS04590	COG0508	dehydrogenase complex catalyzes the overall conversion of
GBB76_RS04600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GBB76_RS04610	COG0148	phosphopyruvate hydratase activity
GBB76_RS04615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GBB76_RS04620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GBB76_RS04655	COG0504	CTP synthase activity
GBB76_RS04665	COG0149	triose-phosphate isomerase activity
GBB76_RS04675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GBB76_RS04685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GBB76_RS04690	COG0134	indole-3-glycerol-phosphate synthase activity
GBB76_RS04695	COG0315	cyclic pyranopterin monophosphate synthase activity
GBB76_RS04700	COG0303	'Molybdopterin
GBB76_RS04710	COG1802	Transcriptional regulator
GBB76_RS04715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GBB76_RS04725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GBB76_RS04730	COG0372	Belongs to the citrate synthase family
GBB76_RS04735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GBB76_RS04740	COG3494	Protein of unknown function (DUF1009)
GBB76_RS04745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GBB76_RS04750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GBB76_RS04755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GBB76_RS04760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GBB76_RS04765	COG0750	zinc metalloprotease
GBB76_RS04775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GBB76_RS04780	COG0233	cytoplasmic translational termination
GBB76_RS04785	COG0528	UMP kinase activity
GBB76_RS04790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GBB76_RS04795	COG0052	Belongs to the universal ribosomal protein uS2 family
GBB76_RS04810	COG1136	(ABC) transporter
GBB76_RS04820	COG0442	prolyl-tRNA aminoacylation
GBB76_RS04830	COG0346	lactoylglutathione lyase activity
GBB76_RS04845	COG1007	ATP synthesis coupled electron transport
GBB76_RS04860	COG0713	ATP synthesis coupled electron transport
GBB76_RS04870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GBB76_RS04880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GBB76_RS04890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GBB76_RS04895	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GBB76_RS04900	COG0649	NAD binding
GBB76_RS04905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GBB76_RS04910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GBB76_RS04920	COG1115	amino acid carrier protein
GBB76_RS04930	COG0628	permease
GBB76_RS04935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GBB76_RS04935	COG0517	IMP dehydrogenase activity
GBB76_RS04940	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GBB76_RS04945	COG1562	ergosterol biosynthetic process
GBB76_RS04960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GBB76_RS04965	COG1862	Preprotein translocase
GBB76_RS04980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GBB76_RS04985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GBB76_RS04990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GBB76_RS04995	COG0805	protein transport
GBB76_RS05000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GBB76_RS05005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GBB76_RS05010	COG3842	ATPase activity
GBB76_RS05015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GBB76_RS05020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GBB76_RS05025	COG1472	Belongs to the glycosyl hydrolase 3 family
GBB76_RS05035	COG0018	arginyl-trna synthetase
GBB76_RS05040	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GBB76_RS05045	COG0316	Belongs to the HesB IscA family
GBB76_RS05060	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GBB76_RS05065	COG0129	dihydroxy-acid dehydratase activity
GBB76_RS05080	COG0525	valine-tRNA ligase activity
GBB76_RS05095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GBB76_RS05105	COG1132	(ABC) transporter
GBB76_RS05145	COG2770	Histidine kinase
GBB76_RS05145	COG2208	phosphoserine phosphatase activity
GBB76_RS05155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GBB76_RS05160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GBB76_RS05175	COG0302	gtp cyclohydrolase
GBB76_RS05180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GBB76_RS05185	COG0517	IMP dehydrogenase activity
GBB76_RS05185	COG0516	GMP reductase activity
GBB76_RS05215	COG2267	carboxylic ester hydrolase activity
GBB76_RS05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GBB76_RS05245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GBB76_RS05250	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GBB76_RS05250	COG0506	proline dehydrogenase activity
GBB76_RS05250	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GBB76_RS05260	COG1289	transmembrane transporter activity
GBB76_RS05275	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GBB76_RS05295	COG0583	DNA-binding transcription factor activity
GBB76_RS05335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GBB76_RS05340	COG1546	Belongs to the CinA family
GBB76_RS05340	COG1058	Belongs to the CinA family
GBB76_RS05345	COG2308	Evidence 4 Homologs of previously reported genes of
GBB76_RS05350	COG1280	lysine exporter protein (LysE YggA)
GBB76_RS05360	COG1305	Transglutaminase-like
GBB76_RS05370	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS05375	COG3932	Exopolysaccharide synthesis, ExoD
GBB76_RS05380	COG5425	PFAM Usg family protein
GBB76_RS05385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GBB76_RS05390	COG0459	protein refolding
GBB76_RS05395	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GBB76_RS05415	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GBB76_RS05420	COG4948	Mandelate Racemase Muconate Lactonizing
GBB76_RS05425	COG2814	Major facilitator Superfamily
GBB76_RS05430	COG0351	phosphomethylpyrimidine kinase
GBB76_RS05440	COG0697	spore germination
GBB76_RS05475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GBB76_RS05480	COG1396	sequence-specific DNA binding
GBB76_RS05490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GBB76_RS05520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GBB76_RS05520	COG3608	succinylglutamate desuccinylase aspartoacylase
GBB76_RS05535	COG2081	HI0933 family
GBB76_RS05570	COG0683	leucine binding
GBB76_RS05575	COG0785	Cytochrome C biogenesis protein
GBB76_RS05580	COG3191	aminopeptidase activity
GBB76_RS05585	COG4175	Glycine betaine
GBB76_RS05585	COG0517	IMP dehydrogenase activity
GBB76_RS05610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GBB76_RS05630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GBB76_RS05635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GBB76_RS05640	COG0047	phosphoribosylformylglycinamidine synthase activity
GBB76_RS05645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GBB76_RS05655	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GBB76_RS05660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GBB76_RS05680	COG0538	isocitrate dehydrogenase activity
GBB76_RS05685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GBB76_RS05690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GBB76_RS05695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GBB76_RS05700	COG0443	Heat shock 70 kDa protein
GBB76_RS05715	COG2059	Chromate
GBB76_RS05720	COG2059	Chromate
GBB76_RS05740	COG0735	belongs to the Fur family
GBB76_RS05750	COG1136	(ABC) transporter
GBB76_RS05750	COG0577	efflux transmembrane transporter activity
GBB76_RS05775	COG2205	protein histidine kinase activity
GBB76_RS05790	COG0251	oxidation-reduction process
GBB76_RS05815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GBB76_RS05845	COG1230	cation diffusion facilitator family transporter
GBB76_RS05850	COG2853	Lipoprotein
GBB76_RS05945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GBB76_RS05955	COG0546	phosphoglycolate phosphatase activity
GBB76_RS05965	COG0776	regulation of translation
GBB76_RS05970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GBB76_RS05975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GBB76_RS05980	COG0740	serine-type endopeptidase activity
GBB76_RS05985	COG0544	peptidyl-prolyl cis-trans isomerase activity
GBB76_RS05995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GBB76_RS05995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GBB76_RS06000	COG0347	Belongs to the P(II) protein family
GBB76_RS06005	COG0174	glutamine synthetase
GBB76_RS06010	COG3706	GGDEF domain
GBB76_RS06020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GBB76_RS06025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GBB76_RS06030	COG1832	CoA-binding protein
GBB76_RS06045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GBB76_RS06055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GBB76_RS06105	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS06120	COG0783	Belongs to the Dps family
GBB76_RS06125	COG1846	Transcriptional regulator
GBB76_RS06130	COG0033	Phosphoglucomutase
GBB76_RS06165	COG3106	COG3106 Predicted ATPase
GBB76_RS06170	COG3768	UPF0283 membrane protein
GBB76_RS06175	COG0633	Ferredoxin
GBB76_RS06195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBB76_RS06200	COG0728	peptidoglycan biosynthetic process
GBB76_RS06215	COG0673	inositol 2-dehydrogenase activity
GBB76_RS06225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GBB76_RS06230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GBB76_RS06235	COG1902	pentaerythritol trinitrate reductase activity
GBB76_RS06255	COG5002	protein histidine kinase activity
GBB76_RS06255	COG5001	Diguanylate cyclase
GBB76_RS06255	COG3447	MASE1 domain protein
GBB76_RS06280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GBB76_RS06285	COG0512	Glutamine amidotransferase of anthranilate synthase
GBB76_RS06290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GBB76_RS06295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GBB76_RS06310	COG1309	transcriptional regulator
GBB76_RS06315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GBB76_RS06325	COG1914	H( )-stimulated, divalent metal cation uptake system
GBB76_RS06350	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GBB76_RS06365	COG3422	double-strand break repair
GBB76_RS06370	COG0481	GTPase activity
GBB76_RS06375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GBB76_RS06385	COG0402	S-adenosylhomocysteine deaminase activity
GBB76_RS06395	COG4603	Belongs to the binding-protein-dependent transport system permease family
GBB76_RS06400	COG3845	ABC transporter
GBB76_RS06405	COG1744	ABC transporter substrate-binding protein PnrA-like
GBB76_RS06415	COG0384	phenazine biosynthesis protein PhzF
GBB76_RS06420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GBB76_RS06440	COG0154	amidase activity
GBB76_RS06445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GBB76_RS06470	COG2226	methyltransferase
GBB76_RS06480	COG1376	ErfK ybiS ycfS ynhG family protein
GBB76_RS06510	COG4122	O-methyltransferase activity
GBB76_RS06520	COG2890	protein-(glutamine-N5) methyltransferase activity
GBB76_RS06535	COG0488	(ABC) transporter
GBB76_RS06540	COG2203	Gaf domain
GBB76_RS06540	COG3706	GGDEF domain
GBB76_RS06540	COG4251	negative regulation of phosphorylation
GBB76_RS06540	COG5001	Diguanylate cyclase
GBB76_RS06545	COG1877	trehalose-phosphatase activity
GBB76_RS06555	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GBB76_RS06585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GBB76_RS06590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GBB76_RS06595	COG0358	DNA primase activity
GBB76_RS06600	COG0640	Transcriptional regulator
GBB76_RS06625	COG0505	Belongs to the CarA family
GBB76_RS06630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GBB76_RS06635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GBB76_RS06640	COG0438	transferase activity, transferring glycosyl groups
GBB76_RS06655	COG1442	glycosyl transferase family 8
GBB76_RS06660	COG1522	sequence-specific DNA binding
GBB76_RS06665	COG0492	ferredoxin-NADP+ reductase activity
GBB76_RS06670	COG0583	DNA-binding transcription factor activity
GBB76_RS06680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GBB76_RS06690	COG0436	Aminotransferase
GBB76_RS06695	COG0625	glutathione transferase activity
GBB76_RS06705	COG2133	pyrroloquinoline quinone binding
GBB76_RS06720	COG3128	pkhd-type hydroxylase
GBB76_RS06745	COG2968	Membrane
GBB76_RS06760	COG0625	glutathione transferase activity
GBB76_RS06770	COG2824	Alkylphosphonate utilization operon protein PhnA
GBB76_RS06780	COG0210	DNA helicase
GBB76_RS06790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GBB76_RS06790	COG2111	Na H antiporter
GBB76_RS06795	COG1006	Multisubunit Na H antiporter MnhC subunit
GBB76_RS06800	COG0651	ATP synthesis coupled electron transport
GBB76_RS06805	COG1863	multisubunit Na H antiporter MnhE subunit
GBB76_RS06810	COG2212	antiporter activity
GBB76_RS06815	COG1320	monovalent cation:proton antiporter activity
GBB76_RS06825	COG3284	Transcriptional regulator
GBB76_RS06830	COG1012	belongs to the aldehyde dehydrogenase family
GBB76_RS06845	COG0745	RESPONSE REGULATOR receiver
GBB76_RS06850	COG2198	Histidine kinase
GBB76_RS06850	COG5002	protein histidine kinase activity
GBB76_RS06850	COG0784	Response regulator, receiver
GBB76_RS06875	COG0410	ABC transporter
GBB76_RS06890	COG0405	Gamma-glutamyltransferase
GBB76_RS06895	COG1671	Belongs to the UPF0178 family
GBB76_RS06905	COG2808	Putative FMN-binding domain
GBB76_RS06910	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GBB76_RS06925	COG3152	Membrane
GBB76_RS06930	COG0556	nucleotide-excision repair
GBB76_RS06935	COG1335	isochorismatase
GBB76_RS06960	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GBB76_RS06965	COG1278	Cold shock
GBB76_RS06970	COG0625	glutathione transferase activity
GBB76_RS06975	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GBB76_RS06980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GBB76_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS07000	COG0322	excinuclease ABC activity
GBB76_RS07005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GBB76_RS07015	COG0314	molybdopterin synthase activity
GBB76_RS07025	COG1846	Transcriptional regulator
GBB76_RS07030	COG0745	RESPONSE REGULATOR receiver
GBB76_RS07040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBB76_RS07065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GBB76_RS07075	COG1496	oxidoreductase activity
GBB76_RS07090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GBB76_RS07100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GBB76_RS07105	COG0193	aminoacyl-tRNA hydrolase activity
GBB76_RS07110	COG0012	GTP binding
GBB76_RS07125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GBB76_RS07125	COG2857	Cytochrome c1
GBB76_RS07130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GBB76_RS07130	COG2857	Cytochrome c1
GBB76_RS07135	COG0723	plastoquinol--plastocyanin reductase activity
GBB76_RS07140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GBB76_RS07145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GBB76_RS07150	COG1132	(ABC) transporter
GBB76_RS07160	COG0408	coproporphyrinogen oxidase activity
GBB76_RS07165	COG0617	tRNA 3'-terminal CCA addition
GBB76_RS07175	COG0494	nUDIX hydrolase
GBB76_RS07185	COG0714	Associated with various cellular activities
GBB76_RS07220	COG3300	MHYT domain
GBB76_RS07220	COG5001	Diguanylate cyclase
GBB76_RS07225	COG0435	Glutathione S-transferase
GBB76_RS07240	COG0482	sulfurtransferase activity
GBB76_RS07250	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GBB76_RS07255	COG3454	Phosphonate metabolism
GBB76_RS07260	COG4778	phosphonate C-P lyase system protein PhnL
GBB76_RS07265	COG4107	phosphonate C-P lyase system protein PhnK
GBB76_RS07275	COG3626	phosphonate metabolism
GBB76_RS07280	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GBB76_RS07285	COG3624	Phosphonate C-P lyase system protein PhnG
GBB76_RS07290	COG2188	Transcriptional regulator
GBB76_RS07300	COG1304	FMN binding
GBB76_RS07315	COG0494	nUDIX hydrolase
GBB76_RS07350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GBB76_RS07350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GBB76_RS07355	COG0247	lactate metabolic process
GBB76_RS07355	COG0277	FAD linked oxidase domain protein
GBB76_RS07360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GBB76_RS07365	COG1802	Transcriptional regulator
GBB76_RS07370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GBB76_RS07375	COG1733	regulation of RNA biosynthetic process
GBB76_RS07395	COG1802	Transcriptional regulator
GBB76_RS07400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GBB76_RS07405	COG1024	Enoyl-CoA hydratase
GBB76_RS07405	COG1250	3-hydroxyacyl-CoA dehydrogenase
GBB76_RS07410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBB76_RS07420	COG2115	Belongs to the xylose isomerase family
GBB76_RS07425	COG1070	Carbohydrate kinase
GBB76_RS07430	COG1609	Transcriptional regulator
GBB76_RS07435	COG4213	ABC transporter substrate-binding protein
GBB76_RS07440	COG4214	carbohydrate transport
GBB76_RS07445	COG1129	ABC transporter
GBB76_RS07480	COG4149	molybdate abc transporter
GBB76_RS07485	COG0725	ABC transporter, periplasmic molybdate-binding protein
GBB76_RS07500	COG1523	belongs to the glycosyl hydrolase 13 family
GBB76_RS07505	COG0297	glycogen (starch) synthase activity
GBB76_RS07515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GBB76_RS07520	COG0058	SHG alpha-glucan phosphorylase activity
GBB76_RS07530	COG1797	cobyrinic acid a,c-diamide synthase activity
GBB76_RS07610	COG1492	cobalamin metabolic process
GBB76_RS07615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GBB76_RS07620	COG0514	ATP-dependent DNA helicase (RecQ)
GBB76_RS07635	COG0500	methyltransferase
GBB76_RS07640	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GBB76_RS07715	COG0659	secondary active sulfate transmembrane transporter activity
GBB76_RS07725	COG2022	thiamine diphosphate biosynthetic process
GBB76_RS07745	COG0671	phosphoesterase, PA-phosphatase related
GBB76_RS07775	COG2814	Major facilitator Superfamily
GBB76_RS07790	COG0628	permease
GBB76_RS07835	COG1007	ATP synthesis coupled electron transport
GBB76_RS07840	COG0651	ATP synthesis coupled electron transport
GBB76_RS07850	COG0786	glutamate:sodium symporter activity
GBB76_RS07855	COG2610	gluconate transmembrane transporter activity
GBB76_RS07870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GBB76_RS07875	COG1278	Cold shock
GBB76_RS07890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GBB76_RS07895	COG0318	PFAM AMP-dependent synthetase and ligase
GBB76_RS07905	COG1802	Transcriptional regulator
GBB76_RS07910	COG1278	Cold shock
GBB76_RS07930	COG1802	Transcriptional regulator
GBB76_RS07935	COG1012	belongs to the aldehyde dehydrogenase family
GBB76_RS07940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GBB76_RS07955	COG3842	ATPase activity
GBB76_RS07970	COG1177	transmembrane transport
GBB76_RS07975	COG0583	DNA-binding transcription factor activity
GBB76_RS07980	COG0477	Major facilitator Superfamily
GBB76_RS07985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GBB76_RS07995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GBB76_RS08005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GBB76_RS08010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GBB76_RS08030	COG0564	pseudouridine synthase activity
GBB76_RS08035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GBB76_RS08065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GBB76_RS08080	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GBB76_RS08110	COG5001	Diguanylate cyclase
GBB76_RS08130	COG0483	inositol monophosphate 1-phosphatase activity
GBB76_RS08155	COG0069	glutamate synthase activity
GBB76_RS08155	COG0067	glutamate synthase
GBB76_RS08155	COG0070	glutamate synthase
GBB76_RS08170	COG2951	lytic endotransglycosylase activity
GBB76_RS08175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GBB76_RS08180	COG0542	response to heat
GBB76_RS08185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GBB76_RS08190	COG0527	aspartate kinase activity
GBB76_RS08200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GBB76_RS08205	COG2890	protein-(glutamine-N5) methyltransferase activity
GBB76_RS08235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GBB76_RS08260	COG0183	Belongs to the thiolase family
GBB76_RS08265	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GBB76_RS08270	COG3300	MHYT domain
GBB76_RS08270	COG5001	Diguanylate cyclase
GBB76_RS08280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GBB76_RS08285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GBB76_RS08290	COG0142	geranyltranstransferase activity
GBB76_RS08300	COG0473	3-isopropylmalate dehydrogenase activity
GBB76_RS08325	COG0251	oxidation-reduction process
GBB76_RS08340	COG3038	cytochrome b561
GBB76_RS08350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GBB76_RS08365	COG4977	sequence-specific DNA binding
GBB76_RS08375	COG0335	large ribosomal subunit rRNA binding
GBB76_RS08390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GBB76_RS08395	COG0228	four-way junction DNA binding
GBB76_RS08400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GBB76_RS08415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GBB76_RS08425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GBB76_RS08440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GBB76_RS08445	COG1040	competence protein
GBB76_RS08450	COG2226	methyltransferase
GBB76_RS08465	COG0494	nUDIX hydrolase
GBB76_RS08470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GBB76_RS08475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GBB76_RS08480	COG0653	protein targeting
GBB76_RS08485	COG3034	peptidoglycan biosynthetic process
GBB76_RS08490	COG0825	malonyl-CoA metabolic process
GBB76_RS08495	COG4974	Belongs to the 'phage' integrase family
GBB76_RS08500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GBB76_RS08505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GBB76_RS08555	COG0181	hydroxymethylbilane synthase activity
GBB76_RS08560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GBB76_RS08565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GBB76_RS08575	COG2264	protein methyltransferase activity
GBB76_RS08580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GBB76_RS08595	COG2902	Dehydrogenase
GBB76_RS08600	COG3047	cAMP biosynthetic process
GBB76_RS08605	COG0138	bifunctional purine biosynthesis protein purh
GBB76_RS08620	COG0837	glucose binding
GBB76_RS08625	COG0564	pseudouridine synthase activity
GBB76_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS08660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GBB76_RS08675	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GBB76_RS08680	COG4689	acetoacetate decarboxylase
GBB76_RS08690	COG0523	cobalamin synthesis protein
GBB76_RS08695	COG0803	Belongs to the bacterial solute-binding protein 9 family
GBB76_RS08700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GBB76_RS08715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GBB76_RS08720	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GBB76_RS08735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GBB76_RS08745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBB76_RS08750	COG0402	S-adenosylhomocysteine deaminase activity
GBB76_RS08760	COG2249	NAD(P)H dehydrogenase (quinone) activity
GBB76_RS08770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GBB76_RS08780	COG2003	Belongs to the UPF0758 family
GBB76_RS08785	COG0024	Methionine aminopeptidase
GBB76_RS08790	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GBB76_RS08790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GBB76_RS08815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GBB76_RS08825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GBB76_RS08845	COG1802	Transcriptional regulator
GBB76_RS08855	COG0028	Belongs to the TPP enzyme family
GBB76_RS08860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GBB76_RS08865	COG4191	Histidine kinase
GBB76_RS08875	COG1414	Transcriptional regulator
GBB76_RS08880	COG3960	tartronate-semialdehyde synthase activity
GBB76_RS08885	COG3622	Belongs to the hyi family
GBB76_RS08890	COG2084	Dehydrogenase
GBB76_RS08895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GBB76_RS08905	COG0045	succinate-CoA ligase (ADP-forming) activity
GBB76_RS08910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GBB76_RS08920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GBB76_RS08925	COG2514	catechol 2,3-dioxygenase activity
GBB76_RS08955	COG0800	Aldolase
GBB76_RS08960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GBB76_RS08985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBB76_RS08995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GBB76_RS08995	COG0446	pyridine nucleotide-disulphide oxidoreductase
GBB76_RS09005	COG1760	l-serine dehydratase
GBB76_RS09015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GBB76_RS09020	COG4638	Rieske (2fe-2S)
GBB76_RS09045	COG1902	pentaerythritol trinitrate reductase activity
GBB76_RS09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
GBB76_RS09050	COG0247	lactate metabolic process
GBB76_RS09050	COG2181	nitrate reductase activity
GBB76_RS09070	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GBB76_RS09075	COG1012	belongs to the aldehyde dehydrogenase family
GBB76_RS09085	COG4176	ABC-type proline glycine betaine transport system permease component
GBB76_RS09095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GBB76_RS09105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GBB76_RS09110	COG0037	tRNA processing
GBB76_RS09120	COG2885	chlorophyll binding
GBB76_RS09125	COG0823	Involved in the tonB-independent uptake of proteins
GBB76_RS09140	COG0811	peptide transport
GBB76_RS09145	COG0824	Thioesterase
GBB76_RS09160	COG2255	four-way junction helicase activity
GBB76_RS09165	COG0632	four-way junction helicase activity
GBB76_RS09170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GBB76_RS09185	COG0217	transcriptional regulatory protein
GBB76_RS09190	COG1692	metallophosphoesterase
GBB76_RS09205	COG0604	alcohol dehydrogenase
GBB76_RS09220	COG0254	rRNA binding
GBB76_RS09225	COG1132	(ABC) transporter
GBB76_RS09245	COG0483	inositol monophosphate 1-phosphatase activity
GBB76_RS09275	COG3588	fructose-bisphosphate aldolase
GBB76_RS09280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GBB76_RS09290	COG0352	thiamine-phosphate diphosphorylase activity
GBB76_RS09305	COG1678	Uncharacterized ACR, COG1678
GBB76_RS09315	COG0678	peroxiredoxin activity
GBB76_RS09345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GBB76_RS09350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GBB76_RS09355	COG0328	RNA-DNA hybrid ribonuclease activity
GBB76_RS09360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GBB76_RS09370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GBB76_RS09415	COG0114	fumarate hydratase activity
GBB76_RS09430	COG0330	HflC and HflK could
GBB76_RS09435	COG0330	HflC and HflK could
GBB76_RS09470	COG3750	Belongs to the UPF0335 family
GBB76_RS09480	COG2989	Protein conserved in bacteria
GBB76_RS09490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GBB76_RS09505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GBB76_RS09510	COG0560	Phosphoserine phosphatase
GBB76_RS09520	COG0277	FAD linked oxidase domain protein
GBB76_RS09530	COG2264	protein methyltransferase activity
GBB76_RS09535	COG0210	DNA helicase
GBB76_RS09550	COG0006	proline dipeptidase activity
GBB76_RS09560	COG1335	isochorismatase
GBB76_RS09565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GBB76_RS09570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GBB76_RS09580	COG0497	DNA recombination
GBB76_RS09585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GBB76_RS09595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GBB76_RS09600	COG0849	cell division
GBB76_RS09605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GBB76_RS09610	COG1181	Belongs to the D-alanine--D-alanine ligase family
GBB76_RS09615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GBB76_RS09620	COG2361	Protein of unknown function DUF86
GBB76_RS09630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GBB76_RS09635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GBB76_RS09645	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GBB76_RS09655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GBB76_RS09660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GBB76_RS09665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GBB76_RS09680	COG0275	rRNA processing
GBB76_RS09685	COG2001	Belongs to the MraZ family
GBB76_RS09690	COG3023	N-Acetylmuramoyl-L-alanine amidase
GBB76_RS09705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GBB76_RS09730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GBB76_RS09735	COG0469	pyruvate kinase activity
GBB76_RS09740	COG1376	ErfK ybiS ycfS ynhG family protein
GBB76_RS09760	COG1215	transferase activity, transferring glycosyl groups
GBB76_RS09780	COG0583	DNA-binding transcription factor activity
GBB76_RS09785	COG2814	Major facilitator Superfamily
GBB76_RS09810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GBB76_RS09830	COG0842	Transport permease protein
GBB76_RS09835	COG0842	Transport permease protein
GBB76_RS09835	COG1129	ABC transporter
GBB76_RS09840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBB76_RS09850	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GBB76_RS09860	COG3038	cytochrome b561
GBB76_RS09865	COG0745	RESPONSE REGULATOR receiver
GBB76_RS09870	COG0642	Histidine kinase
GBB76_RS09890	COG2885	chlorophyll binding
GBB76_RS09900	COG1522	sequence-specific DNA binding
GBB76_RS09920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GBB76_RS09945	COG0110	maltose O-acetyltransferase activity
GBB76_RS09970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GBB76_RS10000	COG2801	Transposase and inactivated derivatives
GBB76_RS10005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GBB76_RS10010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GBB76_RS10030	COG0110	maltose O-acetyltransferase activity
GBB76_RS10035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GBB76_RS10075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GBB76_RS10125	COG2217	Heavy metal translocating P-type atpase
GBB76_RS10135	COG0348	domain, Protein
GBB76_RS10140	COG2010	Cytochrome c
GBB76_RS10170	COG2205	protein histidine kinase activity
GBB76_RS10180	COG0154	amidase activity
GBB76_RS10195	COG4176	ABC-type proline glycine betaine transport system permease component
GBB76_RS10200	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GBB76_RS10235	COG0277	FAD linked oxidase domain protein
GBB76_RS10260	COG0559	Belongs to the binding-protein-dependent transport system permease family
GBB76_RS10275	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GBB76_RS10290	COG1086	Polysaccharide biosynthesis protein
GBB76_RS10305	COG1215	transferase activity, transferring glycosyl groups
GBB76_RS10360	COG3920	Histidine kinase
GBB76_RS10365	COG3459	Glycosyltransferase 36 associated
GBB76_RS10380	COG1278	Cold shock
GBB76_RS10390	COG1845	cytochrome c oxidase, subunit III
GBB76_RS10395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GBB76_RS10400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GBB76_RS10425	COG0583	DNA-binding transcription factor activity
GBB76_RS10495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GBB76_RS10505	COG0175	sulfate reduction
GBB76_RS10510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GBB76_RS10515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GBB76_RS10520	COG4208	sulfate ABC transporter
GBB76_RS10525	COG1238	metal cluster binding
GBB76_RS10530	COG0140	phosphoribosyl-ATP diphosphatase activity
GBB76_RS10535	COG1686	Belongs to the peptidase S11 family
GBB76_RS10540	COG0523	cobalamin synthesis protein
GBB76_RS10550	COG1196	nuclear chromosome segregation
GBB76_RS10550	COG3264	Mechanosensitive ion channel
GBB76_RS10565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GBB76_RS10575	COG0039	L-malate dehydrogenase activity
GBB76_RS10585	COG0508	dehydrogenase complex catalyzes the overall conversion of
GBB76_RS10590	COG1620	l-lactate permease
GBB76_RS10595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GBB76_RS10605	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GBB76_RS10620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GBB76_RS10650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GBB76_RS10685	COG0739	heme binding
GBB76_RS10690	COG0400	carboxylic ester hydrolase activity
GBB76_RS10700	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GBB76_RS10705	COG2819	hydrolase of the alpha beta superfamily
GBB76_RS10710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GBB76_RS10715	COG1120	ATPase activity
GBB76_RS10720	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS10725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GBB76_RS10725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GBB76_RS10730	COG3433	isochorismatase activity
GBB76_RS10730	COG1535	isochorismatase
GBB76_RS10735	COG1535	isochorismatase
GBB76_RS10735	COG3433	isochorismatase activity
GBB76_RS10740	COG1021	2,3-dihydroxybenzoate-AMP ligase
GBB76_RS10745	COG1169	isochorismate synthase
GBB76_RS10760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GBB76_RS10765	COG4558	Periplasmic binding protein
GBB76_RS10770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GBB76_RS10775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GBB76_RS10800	COG1872	DUF167
GBB76_RS10805	COG1247	-acetyltransferase
GBB76_RS10810	COG1217	gtp-binding protein TYPA
GBB76_RS10825	COG1994	Peptidase M50
GBB76_RS10830	COG0137	argininosuccinate synthase activity
GBB76_RS10840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GBB76_RS10850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GBB76_RS10855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GBB76_RS10860	COG0552	protein localization to endoplasmic reticulum
GBB76_RS10865	COG2917	probably involved in intracellular septation
GBB76_RS10895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GBB76_RS10915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GBB76_RS10920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GBB76_RS10930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBB76_RS10935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GBB76_RS10945	COG0667	Aldo Keto reductase
GBB76_RS10960	COG4181	ATPase activity
GBB76_RS10970	COG0670	Belongs to the BI1 family
GBB76_RS10975	COG1733	regulation of RNA biosynthetic process
GBB76_RS10985	COG5507	3-demethylubiquinone-9 3-methyltransferase
GBB76_RS11005	COG1309	transcriptional regulator
GBB76_RS11015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBB76_RS11020	COG1116	anion transmembrane transporter activity
GBB76_RS11030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GBB76_RS11045	COG0402	S-adenosylhomocysteine deaminase activity
GBB76_RS11050	COG2080	2 iron, 2 sulfur cluster binding
GBB76_RS11050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GBB76_RS11065	COG1309	transcriptional regulator
GBB76_RS11075	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS11085	COG4957	zinc ion binding
GBB76_RS11100	COG1802	Transcriptional regulator
GBB76_RS11120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GBB76_RS11125	COG0363	glucosamine-6-phosphate deaminase activity
GBB76_RS11130	COG0129	dihydroxy-acid dehydratase activity
GBB76_RS11160	COG2884	Cell division ATP-binding protein ftsE
GBB76_RS11175	COG0019	diaminopimelate decarboxylase activity
GBB76_RS11195	COG1674	ftsk spoiiie
GBB76_RS11200	COG0436	Aminotransferase
GBB76_RS11205	COG0004	ammonium transporteR
GBB76_RS11210	COG0347	Belongs to the P(II) protein family
GBB76_RS11215	COG1946	Acyl-CoA thioesterase
GBB76_RS11220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GBB76_RS11225	COG2835	tetraacyldisaccharide 4'-kinase activity
GBB76_RS11230	COG1802	Transcriptional regulator
GBB76_RS11235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GBB76_RS11255	COG3118	belongs to the thioredoxin family
GBB76_RS11275	COG1309	transcriptional regulator
GBB76_RS11280	COG0494	nUDIX hydrolase
GBB76_RS11290	COG0793	Belongs to the peptidase S41A family
GBB76_RS11300	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GBB76_RS11305	COG0799	negative regulation of ribosome biogenesis
GBB76_RS11335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GBB76_RS11355	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GBB76_RS11375	COG2086	electron transfer activity
GBB76_RS11380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GBB76_RS11385	COG1250	3-hydroxyacyl-CoA dehydrogenase
GBB76_RS11395	COG5002	protein histidine kinase activity
GBB76_RS11395	COG3447	MASE1 domain protein
GBB76_RS11395	COG5001	Diguanylate cyclase
GBB76_RS11400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GBB76_RS11405	COG0165	Argininosuccinate lyase
GBB76_RS11410	COG2217	Heavy metal translocating P-type atpase
GBB76_RS11415	COG0789	Transcriptional regulator
GBB76_RS11440	COG0287	Prephenate dehydrogenase
GBB76_RS11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GBB76_RS11455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GBB76_RS11460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GBB76_RS11460	COG2813	Specifically methylates the guanine in position
GBB76_RS11465	COG2226	methyltransferase
GBB76_RS11470	COG0513	Belongs to the DEAD box helicase family
GBB76_RS11475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GBB76_RS11480	COG2186	Transcriptional regulator
GBB76_RS11485	COG0352	thiamine-phosphate diphosphorylase activity
GBB76_RS11485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GBB76_RS11485	COG0351	phosphomethylpyrimidine kinase
GBB76_RS11490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GBB76_RS11495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GBB76_RS11500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GBB76_RS11505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GBB76_RS11510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GBB76_RS11515	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GBB76_RS11520	COG4133	protoheme IX ABC transporter activity
GBB76_RS11525	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GBB76_RS11555	COG1691	(AIR) carboxylase
GBB76_RS11570	COG3875	lactate racemase activity
GBB76_RS11575	COG0709	Synthesizes selenophosphate from selenide and ATP
GBB76_RS11580	COG1305	Transglutaminase-like
GBB76_RS11585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GBB76_RS11595	COG0437	4 iron, 4 sulfur cluster binding
GBB76_RS11600	COG2864	formate dehydrogenase
GBB76_RS11640	COG1176	ABC-type spermidine putrescine transport system, permease component I
GBB76_RS11645	COG3842	ATPase activity
GBB76_RS11670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GBB76_RS11675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GBB76_RS11685	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GBB76_RS11690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GBB76_RS11710	COG0310	cobalt ion transport
GBB76_RS11735	COG0824	Thioesterase
GBB76_RS11735	COG1250	3-hydroxyacyl-CoA dehydrogenase
GBB76_RS11740	COG3246	L-lysine catabolic process to acetate
GBB76_RS11755	COG0488	(ABC) transporter
GBB76_RS11760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GBB76_RS11770	COG3842	ATPase activity
GBB76_RS11780	COG1177	transmembrane transport
GBB76_RS11795	COG2183	response to ionizing radiation
GBB76_RS11800	COG1802	Transcriptional regulator
GBB76_RS11850	COG4993	Dehydrogenase
GBB76_RS11855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GBB76_RS11870	COG0714	Associated with various cellular activities
GBB76_RS11925	COG0683	leucine binding
GBB76_RS11950	COG1309	transcriptional regulator
GBB76_RS11955	COG0625	glutathione transferase activity
GBB76_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS11980	COG3220	belongs to the UPF0276 family
GBB76_RS12005	COG0644	oxidoreductase
GBB76_RS12010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GBB76_RS12035	COG0251	oxidation-reduction process
GBB76_RS12060	COG0300	oxidoreductase activity
GBB76_RS12085	COG3479	Phenolic acid decarboxylase
GBB76_RS12095	COG5001	Diguanylate cyclase
GBB76_RS12140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GBB76_RS12150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GBB76_RS12170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GBB76_RS12190	COG1309	transcriptional regulator
GBB76_RS12210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GBB76_RS12235	COG2144	transferase activity, transferring acyl groups
GBB76_RS12240	COG0438	transferase activity, transferring glycosyl groups
GBB76_RS12250	COG2072	flavoprotein involved in K transport
GBB76_RS12345	COG0450	alkyl hydroperoxide reductase
GBB76_RS12350	COG0640	Transcriptional regulator
GBB76_RS12370	COG0785	Cytochrome C biogenesis protein
GBB76_RS12380	COG2010	Cytochrome c
GBB76_RS12385	COG3258	Cytochrome c
GBB76_RS12405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GBB76_RS12420	COG0446	pyridine nucleotide-disulphide oxidoreductase
GBB76_RS12430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GBB76_RS12435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBB76_RS12440	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
GBB76_RS12445	COG3275	phosphorelay sensor kinase activity
GBB76_RS12450	COG3279	Response regulator of the LytR AlgR family
GBB76_RS12465	COG4771	TonB-dependent receptor
GBB76_RS12470	COG0477	Major facilitator Superfamily
GBB76_RS12475	COG0753	catalase activity
GBB76_RS12505	COG4566	intracellular signal transduction
GBB76_RS12560	COG0583	DNA-binding transcription factor activity
GBB76_RS12570	COG0300	oxidoreductase activity
GBB76_RS12580	COG1012	belongs to the aldehyde dehydrogenase family
GBB76_RS12585	COG2223	nitrite transmembrane transporter activity
GBB76_RS12600	COG1176	ABC-type spermidine putrescine transport system, permease component I
GBB76_RS12605	COG1177	transmembrane transport
GBB76_RS12610	COG3842	ATPase activity
GBB76_RS12625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBB76_RS12635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBB76_RS12640	COG3284	Transcriptional regulator
GBB76_RS12645	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GBB76_RS12650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBB76_RS12655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GBB76_RS12660	COG0277	FAD linked oxidase domain protein
GBB76_RS12665	COG3284	Transcriptional regulator
GBB76_RS12675	COG3842	ATPase activity
GBB76_RS12680	COG1177	transmembrane transport
GBB76_RS12685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GBB76_RS12725	COG1032	radical SAM domain protein
GBB76_RS12735	COG0501	Belongs to the peptidase M48B family
GBB76_RS12770	COG4251	negative regulation of phosphorylation
GBB76_RS12770	COG5001	Diguanylate cyclase
GBB76_RS12770	COG3706	GGDEF domain
GBB76_RS12770	COG2203	Gaf domain
GBB76_RS12775	COG0495	leucyl-tRNA aminoacylation
GBB76_RS12800	COG0357	Ribosomal RNA small subunit methyltransferase G
GBB76_RS12805	COG0445	tRNA wobble uridine modification
GBB76_RS12810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GBB76_RS12815	COG1331	Highly conserved protein containing a thioredoxin domain
GBB76_RS12825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GBB76_RS12830	COG1981	membrane
GBB76_RS12835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GBB76_RS12840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GBB76_RS12845	COG0424	maF-like protein
GBB76_RS12850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GBB76_RS12855	COG0237	dephospho-CoA kinase activity
GBB76_RS12860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GBB76_RS12865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GBB76_RS12875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GBB76_RS12890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GBB76_RS12895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GBB76_RS12905	COG0131	Imidazoleglycerol-phosphate dehydratase
GBB76_RS12915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GBB76_RS12920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GBB76_RS12925	COG0107	imidazoleglycerol-phosphate synthase activity
GBB76_RS12930	COG0140	phosphoribosyl-ATP diphosphatase activity
GBB76_RS12935	COG1072	(Pantothenic acid kinase))
GBB76_RS12950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GBB76_RS12955	COG1420	regulation of RNA biosynthetic process
GBB76_RS12960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GBB76_RS12965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GBB76_RS12970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GBB76_RS12980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GBB76_RS12985	COG0792	nuclease activity
GBB76_RS12990	COG0189	ligase activity
GBB76_RS13000	COG0071	Belongs to the small heat shock protein (HSP20) family
GBB76_RS13010	COG0606	chelatase, subunit chli
GBB76_RS13025	COG3383	formate dehydrogenase (NAD+) activity
GBB76_RS13030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GBB76_RS13040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GBB76_RS13040	COG0475	glutathione-regulated potassium exporter activity
GBB76_RS13045	COG0561	phosphatase activity
GBB76_RS13050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GBB76_RS13055	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GBB76_RS13070	COG1271	oxidase subunit
GBB76_RS13075	COG0243	molybdopterin cofactor binding
GBB76_RS13085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GBB76_RS13090	COG0025	NhaP-type Na H and K H
GBB76_RS13105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBB76_RS13125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GBB76_RS13130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GBB76_RS13145	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GBB76_RS13170	COG0539	negative regulation of cytoplasmic translation
GBB76_RS13180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GBB76_RS13185	COG5310	Homospermidine synthase
GBB76_RS13200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GBB76_RS13200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GBB76_RS13205	COG0101	tRNA pseudouridine synthase activity
GBB76_RS13210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GBB76_RS13225	COG2095	MarC family integral membrane protein
GBB76_RS13235	COG0196	riboflavin kinase activity
GBB76_RS13240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GBB76_RS13245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GBB76_RS13255	COG0612	Peptidase, M16
GBB76_RS13260	COG0612	Peptidase, M16
GBB76_RS13285	COG0277	FAD linked oxidase domain protein
GBB76_RS13295	COG0277	FAD linked oxidase domain protein
GBB76_RS13300	COG0247	lactate metabolic process
GBB76_RS13325	COG1185	polyribonucleotide nucleotidyltransferase activity
GBB76_RS13330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GBB76_RS13340	COG1733	regulation of RNA biosynthetic process
GBB76_RS13345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GBB76_RS13350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GBB76_RS13355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GBB76_RS13370	COG0779	Required for maturation of 30S ribosomal subunits
GBB76_RS13375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GBB76_RS13380	COG1742	UPF0060 membrane protein
GBB76_RS13385	COG0142	geranyltranstransferase activity
GBB76_RS13390	COG3754	Rhamnan synthesis protein F
GBB76_RS13415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBB76_RS13420	COG1136	(ABC) transporter
GBB76_RS13420	COG0577	efflux transmembrane transporter activity
GBB76_RS13425	COG0151	Belongs to the GarS family
GBB76_RS13435	COG0590	tRNA wobble adenosine to inosine editing
GBB76_RS13440	COG1187	pseudouridine synthase activity
GBB76_RS13445	COG0742	ribosomal rna small subunit methyltransferase
GBB76_RS13455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GBB76_RS13465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GBB76_RS13470	COG0159	tryptophan synthase activity
GBB76_RS13475	COG0133	tryptophan synthase activity
GBB76_RS13480	COG0135	phosphoribosylanthranilate isomerase activity
GBB76_RS13485	COG4150	thiosulfate binding
GBB76_RS13490	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GBB76_RS13495	COG4208	sulfate ABC transporter
GBB76_RS13500	COG2423	ornithine cyclodeaminase activity
GBB76_RS13510	COG0776	regulation of translation
GBB76_RS13515	COG0616	signal peptide processing
GBB76_RS13525	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GBB76_RS13530	COG3454	Phosphonate metabolism
GBB76_RS13545	COG0019	diaminopimelate decarboxylase activity
GBB76_RS13555	COG1764	response to oxidative stress
GBB76_RS13560	COG0354	folic acid binding
GBB76_RS13565	COG0519	Catalyzes the synthesis of GMP from XMP
GBB76_RS13570	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GBB76_RS13615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GBB76_RS13620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GBB76_RS13625	COG1396	sequence-specific DNA binding
GBB76_RS13630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GBB76_RS13635	COG1253	flavin adenine dinucleotide binding
GBB76_RS13640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GBB76_RS13645	COG1702	phosphate starvation-inducible protein PhoH
GBB76_RS13675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GBB76_RS13690	COG0180	Tryptophanyl-tRNA synthetase
GBB76_RS13700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GBB76_RS13710	COG0670	Belongs to the BI1 family
GBB76_RS13740	COG3685	Protein conserved in bacteria
GBB76_RS13750	COG1473	amidohydrolase
GBB76_RS13765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GBB76_RS13805	COG0483	inositol monophosphate 1-phosphatase activity
GBB76_RS13820	COG1519	Transferase
GBB76_RS13825	COG1663	tetraacyldisaccharide 4'-kinase activity
GBB76_RS13835	COG1570	exodeoxyribonuclease VII activity
GBB76_RS13840	COG0752	glycyl-tRNA synthetase alpha subunit
GBB76_RS13845	COG0751	glycine-tRNA ligase activity
GBB76_RS13855	COG2259	Doxx family
GBB76_RS13860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GBB76_RS13860	COG0574	Belongs to the PEP-utilizing enzyme family
GBB76_RS13865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GBB76_RS13880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GBB76_RS13890	COG2171	N-acyltransferase activity
GBB76_RS13895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GBB76_RS13920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GBB76_RS13930	COG0284	orotidine-5'-phosphate decarboxylase activity
GBB76_RS13935	COG0431	NADPH-dependent FMN reductase
GBB76_RS13940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GBB76_RS13945	COG0484	heat shock protein binding
GBB76_RS13950	COG0443	Heat shock 70 kDa protein
GBB76_RS13970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GBB76_RS13980	COG1309	transcriptional regulator
GBB76_RS13985	COG3158	transport of potassium into the cell
GBB76_RS14000	COG2326	polyphosphate kinase activity
GBB76_RS14005	COG5002	protein histidine kinase activity
GBB76_RS14010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GBB76_RS14015	COG0573	inorganic phosphate transmembrane transporter activity
GBB76_RS14025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GBB76_RS14030	COG0704	Plays a role in the regulation of phosphate uptake
GBB76_RS14035	COG0745	RESPONSE REGULATOR receiver
GBB76_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS14080	COG2186	Transcriptional regulator
GBB76_RS14085	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GBB76_RS14105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBB76_RS14120	COG0402	S-adenosylhomocysteine deaminase activity
GBB76_RS14135	COG0179	Fumarylacetoacetate (FAA) hydrolase
GBB76_RS14150	COG2267	carboxylic ester hydrolase activity
GBB76_RS14165	COG1177	transmembrane transport
GBB76_RS14170	COG3842	ATPase activity
GBB76_RS14180	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS14215	COG0559	Belongs to the binding-protein-dependent transport system permease family
GBB76_RS14255	COG1335	isochorismatase
GBB76_RS14260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBB76_RS14265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GBB76_RS14270	COG1522	sequence-specific DNA binding
GBB76_RS14290	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS14300	COG0010	Belongs to the arginase family
GBB76_RS14310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GBB76_RS14325	COG0395	ABC-type sugar transport system, permease component
GBB76_RS14340	COG3842	ATPase activity
GBB76_RS14355	COG1175	transmembrane transport
GBB76_RS14360	COG0395	ABC-type sugar transport system, permease component
GBB76_RS14375	COG3842	ATPase activity
GBB76_RS14385	COG1461	Dihydroxyacetone kinase
GBB76_RS14400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GBB76_RS14400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GBB76_RS14410	COG2376	Dihydroxyacetone kinase
GBB76_RS14415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GBB76_RS14420	COG1566	PFAM secretion protein HlyD family protein
GBB76_RS14430	COG1289	transmembrane transporter activity
GBB76_RS14435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GBB76_RS14440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GBB76_RS14445	COG2326	polyphosphate kinase activity
GBB76_RS14450	COG1879	ABC-type sugar transport system periplasmic component
GBB76_RS14455	COG1172	Belongs to the binding-protein-dependent transport system permease family
GBB76_RS14465	COG0673	inositol 2-dehydrogenase activity
GBB76_RS14475	COG1609	Transcriptional regulator
GBB76_RS14490	COG0583	DNA-binding transcription factor activity
GBB76_RS14500	COG0477	Major facilitator Superfamily
GBB76_RS14510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBB76_RS14515	COG1116	anion transmembrane transporter activity
GBB76_RS14590	COG2308	Evidence 4 Homologs of previously reported genes of
GBB76_RS14590	COG2307	Protein conserved in bacteria
GBB76_RS14600	COG2223	nitrite transmembrane transporter activity
GBB76_RS14605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GBB76_RS14620	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GBB76_RS14630	COG0745	RESPONSE REGULATOR receiver
GBB76_RS14635	COG2205	protein histidine kinase activity
GBB76_RS14645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GBB76_RS14645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GBB76_RS14650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GBB76_RS14655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GBB76_RS14690	COG0443	Heat shock 70 kDa protein
GBB76_RS14695	COG3932	Exopolysaccharide synthesis, ExoD
GBB76_RS14740	COG0587	DNA-directed DNA polymerase activity
GBB76_RS14760	COG1846	Transcriptional regulator
GBB76_RS14765	COG0583	DNA-binding transcription factor activity
GBB76_RS14770	COG0346	lactoylglutathione lyase activity
GBB76_RS14775	COG0400	carboxylic ester hydrolase activity
GBB76_RS14780	COG2321	neutral zinc metallopeptidase
GBB76_RS14785	COG0521	Mo-molybdopterin cofactor biosynthetic process
GBB76_RS14805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GBB76_RS14820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GBB76_RS14835	COG1522	sequence-specific DNA binding
GBB76_RS14840	COG1196	nuclear chromosome segregation
GBB76_RS14850	COG0356	it plays a direct role in the translocation of protons across the membrane
GBB76_RS14855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GBB76_RS14860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GBB76_RS14865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GBB76_RS14875	COG0009	L-threonylcarbamoyladenylate synthase
GBB76_RS14880	COG0123	including yeast histone deacetylase and acetoin utilization protein
GBB76_RS14885	COG1722	exodeoxyribonuclease VII activity
GBB76_RS14895	COG3813	Protein conserved in bacteria
GBB76_RS14910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GBB76_RS14925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GBB76_RS14935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GBB76_RS14935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GBB76_RS14940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GBB76_RS14945	COG1253	flavin adenine dinucleotide binding
GBB76_RS14955	COG1643	Atp-dependent helicase
GBB76_RS14960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GBB76_RS14975	COG0124	histidyl-tRNA synthetase
GBB76_RS14985	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GBB76_RS14990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GBB76_RS14995	COG1648	precorrin-2 dehydrogenase activity
GBB76_RS14995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GBB76_RS15010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GBB76_RS15020	COG3278	Belongs to the heme-copper respiratory oxidase family
GBB76_RS15035	COG2010	Cytochrome c
GBB76_RS15050	COG2217	Heavy metal translocating P-type atpase
GBB76_RS15070	COG1309	transcriptional regulator
GBB76_RS15075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GBB76_RS15080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GBB76_RS15100	COG2223	nitrite transmembrane transporter activity
GBB76_RS15110	COG2816	NAD+ diphosphatase activity
GBB76_RS15120	COG0717	Belongs to the dCTP deaminase family
GBB76_RS15130	COG2967	ApaG domain
GBB76_RS15135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GBB76_RS15150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GBB76_RS15155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GBB76_RS15170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GBB76_RS15180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GBB76_RS15195	COG3920	Histidine kinase
GBB76_RS15195	COG2202	Pas domain
GBB76_RS15200	COG0784	Response regulator, receiver
GBB76_RS15215	COG5487	UPF0391 membrane protein
GBB76_RS15220	COG0583	DNA-binding transcription factor activity
GBB76_RS15230	COG0242	peptide deformylase activity
GBB76_RS15235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GBB76_RS15245	COG0450	alkyl hydroperoxide reductase
GBB76_RS15270	COG0167	dihydroorotate dehydrogenase activity
GBB76_RS15285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GBB76_RS15285	COG1793	dna ligase
GBB76_RS15300	COG1201	RNA secondary structure unwinding
GBB76_RS15315	COG0789	Transcriptional regulator
GBB76_RS15330	COG0657	acetylesterase activity
GBB76_RS15335	COG0432	Pfam Uncharacterised protein family UPF0047
GBB76_RS15345	COG2205	protein histidine kinase activity
GBB76_RS15345	COG3850	Histidine kinase
GBB76_RS15345	COG4999	Histidine kinase
GBB76_RS15345	COG3437	response regulator, receiver
GBB76_RS15350	COG1970	mechanosensitive ion channel activity
GBB76_RS15355	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GBB76_RS15380	COG4191	Histidine kinase
GBB76_RS15385	COG4566	intracellular signal transduction
GBB76_RS15390	COG0745	RESPONSE REGULATOR receiver
GBB76_RS15395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GBB76_RS15400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GBB76_RS15410	COG0156	8-amino-7-oxononanoate synthase activity
GBB76_RS15420	COG0010	Belongs to the arginase family
GBB76_RS15425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GBB76_RS15450	COG3842	ATPase activity
GBB76_RS15460	COG1176	ABC-type spermidine putrescine transport system, permease component I
GBB76_RS15465	COG0395	ABC-type sugar transport system, permease component
GBB76_RS15470	COG5001	Diguanylate cyclase
GBB76_RS15470	COG3300	MHYT domain
GBB76_RS15500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GBB76_RS15510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GBB76_RS15515	COG5328	Belongs to the UPF0262 family
GBB76_RS15525	COG0424	maF-like protein
GBB76_RS15530	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GBB76_RS15605	COG1294	oxidase, subunit
GBB76_RS15615	COG4988	ABC transporter
GBB76_RS15620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GBB76_RS15625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GBB76_RS15630	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GBB76_RS15635	COG1984	allophanate hydrolase subunit 2
GBB76_RS15640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GBB76_RS15655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GBB76_RS15660	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GBB76_RS15700	COG3938	Belongs to the proline racemase family
GBB76_RS15705	COG4948	Mandelate Racemase Muconate Lactonizing
GBB76_RS15710	COG3938	Belongs to the proline racemase family
GBB76_RS15715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBB76_RS15720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GBB76_RS15725	COG1126	abc transporter atp-binding protein
GBB76_RS15745	COG1802	Transcriptional regulator
GBB76_RS15755	COG0583	DNA-binding transcription factor activity
GBB76_RS15760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GBB76_RS15765	COG3246	L-lysine catabolic process to acetate
GBB76_RS15810	COG3064	Membrane
GBB76_RS15840	COG0531	amino acid
GBB76_RS15855	COG2235	arginine
GBB76_RS15880	COG0438	transferase activity, transferring glycosyl groups
GBB76_RS15890	COG1063	alcohol dehydrogenase
GBB76_RS15895	COG2943	transferase activity, transferring hexosyl groups
GBB76_RS15915	COG0235	Class ii aldolase
GBB76_RS15920	COG3395	kinase activity
GBB76_RS15930	COG2186	Transcriptional regulator
GBB76_RS15935	COG1250	3-hydroxyacyl-CoA dehydrogenase
GBB76_RS15940	COG1172	Belongs to the binding-protein-dependent transport system permease family
GBB76_RS15945	COG1129	ABC transporter
GBB76_RS15995	COG1309	transcriptional regulator
GBB76_RS16005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GBB76_RS16010	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
GBB76_RS16035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GBB76_RS16070	COG0735	belongs to the Fur family
GBB76_RS16075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GBB76_RS16085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GBB76_RS16095	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GBB76_RS16100	COG3474	cytochrome
GBB76_RS16105	COG4166	transmembrane transport
GBB76_RS16115	COG4174	ABC transporter (Permease)
GBB76_RS16120	COG4239	(ABC) transporter, permease
GBB76_RS16125	COG4172	Belongs to the ABC transporter superfamily
GBB76_RS16145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GBB76_RS16160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GBB76_RS16165	COG0484	heat shock protein binding
GBB76_RS16175	COG0259	pyridoxamine-phosphate oxidase activity
GBB76_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS16195	COG1388	LysM domain
GBB76_RS16195	COG1376	ErfK ybiS ycfS ynhG family protein
GBB76_RS16200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBB76_RS16205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GBB76_RS16235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GBB76_RS16255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GBB76_RS16260	COG0288	reversible hydration of carbon dioxide
GBB76_RS16285	COG1846	Transcriptional regulator
GBB76_RS16290	COG0410	ABC transporter
GBB76_RS16325	COG1376	ErfK ybiS ycfS ynhG family protein
GBB76_RS16330	COG2226	methyltransferase
GBB76_RS16335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GBB76_RS16350	COG0756	dUTP diphosphatase activity
GBB76_RS16355	COG1959	2 iron, 2 sulfur cluster binding
GBB76_RS16365	COG2205	protein histidine kinase activity
GBB76_RS16370	COG3178	'Phosphotransferase
GBB76_RS16375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GBB76_RS16380	COG2887	Belongs to the helicase family. UvrD subfamily
GBB76_RS16385	COG1074	ATP-dependent DNA helicase activity
GBB76_RS16405	COG3161	chorismate lyase activity
GBB76_RS16420	COG1968	undecaprenyl-diphosphatase activity
GBB76_RS16425	COG4991	sh3 domain protein
GBB76_RS16430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GBB76_RS16435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GBB76_RS16440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GBB76_RS16450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GBB76_RS16450	COG0072	phenylalanine-tRNA ligase activity
GBB76_RS16465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GBB76_RS16485	COG0588	phosphoglycerate mutase activity
GBB76_RS16490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GBB76_RS16495	COG0028	Belongs to the TPP enzyme family
GBB76_RS16500	COG0440	acetolactate synthase activity
GBB76_RS16510	COG1309	transcriptional regulator
GBB76_RS16515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GBB76_RS16555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GBB76_RS16560	COG0586	Pfam SNARE associated Golgi protein
GBB76_RS16565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBB76_RS16570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GBB76_RS16575	COG1177	transmembrane transport
GBB76_RS16580	COG1176	ABC-type spermidine putrescine transport system, permease component I
GBB76_RS16585	COG3842	ATPase activity
GBB76_RS16590	COG0174	glutamine synthetase
GBB76_RS16605	COG0583	DNA-binding transcription factor activity
GBB76_RS16615	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GBB76_RS16630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GBB76_RS16635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GBB76_RS16645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GBB76_RS16650	COG1137	ATPase activity
GBB76_RS16655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GBB76_RS16660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GBB76_RS16665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GBB76_RS16675	COG1063	alcohol dehydrogenase
GBB76_RS16680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GBB76_RS16685	COG0706	membrane insertase activity
GBB76_RS16690	COG0594	ribonuclease P activity
GBB76_RS16695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GBB76_RS16700	COG3852	Histidine kinase
GBB76_RS16715	COG0583	DNA-binding transcription factor activity
GBB76_RS16730	COG2948	multi-organism process
GBB76_RS16740	COG3701	Conjugal transfer protein
GBB76_RS16745	COG3846	protein secretion by the type IV secretion system
GBB76_RS16760	COG3451	type IV secretory pathway VirB4
GBB76_RS16775	COG4962	Type ii secretion system protein e
GBB76_RS16785	COG3177	Filamentation induced by cAMP protein fic
GBB76_RS16820	COG0741	lytic transglycosylase activity
GBB76_RS16840	COG1192	Involved in chromosome partitioning
GBB76_RS16870	COG1476	TRANSCRIPTIONal
GBB76_RS16875	COG0583	DNA-binding transcription factor activity
GBB76_RS16885	COG1802	Transcriptional regulator
GBB76_RS16890	COG3842	ATPase activity
GBB76_RS16900	COG1176	ABC-type spermidine putrescine transport system, permease component I
GBB76_RS16915	COG0154	amidase activity
GBB76_RS16935	COG0006	proline dipeptidase activity
GBB76_RS16950	COG1476	TRANSCRIPTIONal
GBB76_RS16955	COG5489	Protein of unknown function (DUF736)
GBB76_RS16965	COG1487	ribonuclease activity
GBB76_RS16970	COG4691	Plasmid stability protein
GBB76_RS16995	COG0640	Transcriptional regulator
GBB76_RS17000	COG0701	Predicted permease
GBB76_RS17015	COG1230	cation diffusion facilitator family transporter
GBB76_RS17030	COG0581	inorganic phosphate transmembrane transporter activity
GBB76_RS17035	COG0573	inorganic phosphate transmembrane transporter activity
GBB76_RS17040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GBB76_RS17045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GBB76_RS17060	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GBB76_RS17065	COG3639	organic phosphonate transmembrane transporter activity
GBB76_RS17075	COG2072	flavoprotein involved in K transport
GBB76_RS17100	COG4191	Histidine kinase
GBB76_RS17110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GBB76_RS17125	COG0659	secondary active sulfate transmembrane transporter activity
GBB76_RS17130	COG0589	response to stress
GBB76_RS17135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GBB76_RS17220	COG4983	Phage plasmid primase, P4 family domain protein
GBB76_RS17305	COG1525	nuclease
GBB76_RS17345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GBB76_RS17365	COG0798	PFAM Bile acid sodium symporter
GBB76_RS17390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GBB76_RS17400	COG2140	Oxalate decarboxylase
GBB76_RS17410	COG1346	cytolysis
GBB76_RS17415	COG1380	Effector of murein hydrolase LrgA
GBB76_RS17420	COG3119	arylsulfatase activity
GBB76_RS17430	COG0583	DNA-binding transcription factor activity
GBB76_RS17435	COG0583	DNA-binding transcription factor activity
GBB76_RS17440	COG2855	membrane
GBB76_RS17450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GBB76_RS17450	COG3453	Protein conserved in bacteria
GBB76_RS17455	COG0640	Transcriptional regulator
GBB76_RS17470	COG1275	C4-dicarboxylate transporter malic acid transport protein
GBB76_RS17475	COG1858	cytochrome C peroxidase
GBB76_RS17480	COG0531	amino acid
GBB76_RS17485	COG2066	Belongs to the glutaminase family
GBB76_RS17495	COG0174	glutamine synthetase
GBB76_RS17500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GBB76_RS17505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GBB76_RS17515	COG2217	Heavy metal translocating P-type atpase
GBB76_RS17525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GBB76_RS17535	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GBB76_RS17555	COG1850	ribulose-bisphosphate carboxylase activity
GBB76_RS17585	COG0586	Pfam SNARE associated Golgi protein
GBB76_RS17610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBB76_RS17630	COG0765	amino acid transport
GBB76_RS17635	COG0765	amino acid transport
GBB76_RS17645	COG2186	Transcriptional regulator
GBB76_RS17665	COG4770	biotin carboxylase activity
GBB76_RS17670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GBB76_RS17675	COG1396	sequence-specific DNA binding
GBB76_RS17675	COG3800	Transcriptional regulator
GBB76_RS17690	COG0069	glutamate synthase activity
GBB76_RS17695	COG2218	PFAM glutamate synthase alpha subunit domain protein
GBB76_RS17700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GBB76_RS17715	COG2827	Endonuclease containing a URI domain
GBB76_RS17720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GBB76_RS17735	COG0446	pyridine nucleotide-disulphide oxidoreductase
GBB76_RS17735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GBB76_RS17745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GBB76_RS17760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GBB76_RS17765	COG2723	6-phospho-beta-galactosidase activity
GBB76_RS17775	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GBB76_RS17775	COG4124	Belongs to the glycosyl hydrolase 26 family
GBB76_RS17780	COG0318	PFAM AMP-dependent synthetase and ligase
GBB76_RS17785	COG1280	lysine exporter protein (LysE YggA)
GBB76_RS17790	COG1937	Protein conserved in bacteria
GBB76_RS17800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GBB76_RS17815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GBB76_RS17825	COG0456	acetyltransferase
GBB76_RS17835	COG0656	L-ascorbic acid biosynthetic process
GBB76_RS17840	COG1122	ATPase activity
GBB76_RS17845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GBB76_RS17850	COG1268	BioY protein
GBB76_RS17855	COG0318	PFAM AMP-dependent synthetase and ligase
GBB76_RS17860	COG0183	Belongs to the thiolase family
GBB76_RS17870	COG0667	Aldo Keto reductase
GBB76_RS17875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GBB76_RS17900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GBB76_RS17905	COG3842	ATPase activity
GBB76_RS17910	COG1176	ABC-type spermidine putrescine transport system, permease component I
GBB76_RS17915	COG1177	transmembrane transport
GBB76_RS17920	COG1012	belongs to the aldehyde dehydrogenase family
GBB76_RS17925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBB76_RS17930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GBB76_RS17940	COG1136	(ABC) transporter
GBB76_RS17940	COG0577	efflux transmembrane transporter activity
GBB76_RS17945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GBB76_RS17955	COG1215	transferase activity, transferring glycosyl groups
GBB76_RS17980	COG0477	Major facilitator Superfamily
GBB76_RS17995	COG2235	arginine
GBB76_RS18010	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GBB76_RS18045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GBB76_RS18065	COG1595	DNA-templated transcription, initiation
GBB76_RS18080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GBB76_RS18100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBB76_RS18110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GBB76_RS18120	COG0538	isocitrate dehydrogenase activity
GBB76_RS18125	COG1802	Transcriptional regulator
GBB76_RS18140	COG1175	transmembrane transport
GBB76_RS18155	COG3842	ATPase activity
GBB76_RS18160	COG1028	Short-chain dehydrogenase reductase Sdr
GBB76_RS18170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GBB76_RS18175	COG1175	transmembrane transport
GBB76_RS18185	COG0395	ABC-type sugar transport system, permease component
GBB76_RS18190	COG3842	ATPase activity
GBB76_RS18200	COG1349	DNA-binding transcription factor activity
GBB76_RS18205	COG0434	BtpA family
GBB76_RS18210	COG1070	Carbohydrate kinase
GBB76_RS18255	COG3181	Tripartite tricarboxylate transporter family receptor
GBB76_RS18275	COG2267	carboxylic ester hydrolase activity
GBB76_RS18315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GBB76_RS18325	COG2301	Belongs to the HpcH HpaI aldolase family
GBB76_RS18345	COG4948	Mandelate Racemase Muconate Lactonizing
GBB76_RS18350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GBB76_RS18365	COG0439	Biotin carboxylase
GBB76_RS18370	COG0511	ligase activity, forming carbon-carbon bonds
GBB76_RS18375	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GBB76_RS18390	COG0243	molybdopterin cofactor binding
GBB76_RS18395	COG0437	4 iron, 4 sulfur cluster binding
GBB76_RS18400	COG3302	dmso reductase anchor subunit
GBB76_RS18415	COG1755	Isoprenylcysteine carboxyl methyltransferase
GBB76_RS18430	COG2188	Transcriptional regulator
GBB76_RS18470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GBB76_RS18475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GBB76_RS18480	COG1126	abc transporter atp-binding protein
GBB76_RS18500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GBB76_RS18515	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GBB76_RS18535	COG5001	Diguanylate cyclase
GBB76_RS18535	COG2203	Gaf domain
GBB76_RS18535	COG4251	negative regulation of phosphorylation
GBB76_RS18535	COG3706	GGDEF domain
GBB76_RS18540	COG1999	signal sequence binding
GBB76_RS18570	COG0028	Belongs to the TPP enzyme family
GBB76_RS18600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP