locus-tag	class	description
CB4_RS00010	COG3829	transcription factor binding
CB4_RS00015	COG1509	lysine 2,3-aminomutase activity
CB4_RS00025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_RS00040	COG2323	membrane
CB4_RS00055	COG2814	Major facilitator Superfamily
CB4_RS00065	COG3973	AAA domain
CB4_RS00080	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_RS00150	COG5002	protein histidine kinase activity
CB4_RS00155	COG0745	RESPONSE REGULATOR receiver
CB4_RS00165	COG0735	belongs to the Fur family
CB4_RS00170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CB4_RS00175	COG1121	(ABC) transporter
CB4_RS00185	COG2217	Heavy metal translocating P-type atpase
CB4_RS00190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CB4_RS00195	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CB4_RS00215	COG3290	protein histidine kinase activity
CB4_RS00215	COG3829	transcription factor binding
CB4_RS00225	COG1012	belongs to the aldehyde dehydrogenase family
CB4_RS00230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CB4_RS00235	COG0477	Major facilitator Superfamily
CB4_RS00250	COG1592	Rubrerythrin
CB4_RS00255	COG0531	amino acid
CB4_RS00260	COG0531	amino acid
CB4_RS00265	COG2116	formate transmembrane transporter activity
CB4_RS00275	COG3383	formate dehydrogenase (NAD+) activity
CB4_RS00285	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CB4_RS00290	COG4977	sequence-specific DNA binding
CB4_RS00290	COG1917	Cupin 2, conserved barrel domain protein
CB4_RS00300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CB4_RS00370	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CB4_RS00375	COG1024	Enoyl-CoA hydratase
CB4_RS00380	COG0288	reversible hydration of carbon dioxide
CB4_RS00390	COG5002	protein histidine kinase activity
CB4_RS00395	COG0778	Nitroreductase
CB4_RS00405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CB4_RS00415	COG4149	molybdate abc transporter
CB4_RS00420	COG0725	ABC transporter, periplasmic molybdate-binding protein
CB4_RS00425	COG1910	domain protein
CB4_RS00430	COG0442	prolyl-tRNA aminoacylation
CB4_RS00435	COG0626	cystathionine gamma-synthase activity
CB4_RS00440	COG0626	cystathionine gamma-synthase activity
CB4_RS00455	COG1113	amino acid transport
CB4_RS00460	COG2199	diguanylate cyclase activity
CB4_RS00460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_RS00470	COG1704	LemA family
CB4_RS00480	COG2986	histidine ammonia-lyase
CB4_RS00485	COG0477	Major facilitator Superfamily
CB4_RS00490	COG0010	Belongs to the arginase family
CB4_RS00495	COG1228	amidohydrolase
CB4_RS00505	COG3279	Response regulator of the LytR AlgR family
CB4_RS00515	COG0833	amino acid
CB4_RS00520	COG2986	histidine ammonia-lyase
CB4_RS00540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_RS00560	COG0109	protoheme IX farnesyltransferase activity
CB4_RS00565	COG5278	phosphoserine phosphatase activity
CB4_RS00565	COG0840	transmembrane signaling receptor activity
CB4_RS00580	COG1846	Transcriptional regulator
CB4_RS00590	COG0702	epimerase
CB4_RS00595	COG2318	DinB family
CB4_RS00605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CB4_RS00610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CB4_RS00615	COG4856	YbbR-like protein
CB4_RS00620	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CB4_RS00625	COG5662	AntiSigma factor
CB4_RS00630	COG1595	DNA-templated transcription, initiation
CB4_RS00635	COG0010	Belongs to the arginase family
CB4_RS00740	COG0726	polysaccharide deacetylase
CB4_RS00750	COG0489	protein tyrosine kinase activity
CB4_RS00755	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_RS00765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CB4_RS00770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CB4_RS00775	COG0514	ATP-dependent DNA helicase (RecQ)
CB4_RS00780	COG4585	Histidine kinase
CB4_RS00785	COG0840	transmembrane signaling receptor activity
CB4_RS00795	COG0101	tRNA pseudouridine synthase activity
CB4_RS00800	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CB4_RS00805	COG1122	ATPase activity
CB4_RS00810	COG1122	ATPase activity
CB4_RS00815	COG0203	ribosomal protein L17
CB4_RS00820	COG0202	RNA polymerase activity
CB4_RS00825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CB4_RS00830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CB4_RS00835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CB4_RS00840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CB4_RS00845	COG0024	Methionine aminopeptidase
CB4_RS00850	COG0563	adenylate kinase activity
CB4_RS00855	COG0201	protein transport
CB4_RS00860	COG0200	Binds to the 23S rRNA
CB4_RS00865	COG1841	ribosomal large subunit assembly
CB4_RS00870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CB4_RS00875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CB4_RS00880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CB4_RS00885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CB4_RS00890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CB4_RS00895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CB4_RS00900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CB4_RS00905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CB4_RS00910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CB4_RS00915	COG0255	Belongs to the universal ribosomal protein uL29 family
CB4_RS00920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CB4_RS00925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CB4_RS00930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CB4_RS00935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CB4_RS00940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CB4_RS00945	COG0089	rRNA binding
CB4_RS00950	COG0088	Forms part of the polypeptide exit tunnel
CB4_RS00955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CB4_RS00960	COG0051	transcription antitermination factor activity, RNA binding
CB4_RS00980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_RS00980	COG2199	diguanylate cyclase activity
CB4_RS01010	COG0789	Transcriptional regulator
CB4_RS01090	COG0704	Plays a role in the regulation of phosphate uptake
CB4_RS01095	COG0772	Belongs to the SEDS family
CB4_RS01100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CB4_RS01110	COG0049	tRNA binding
CB4_RS01115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CB4_RS01120	COG1358	cellular component organization or biogenesis
CB4_RS01125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CB4_RS01130	COG0085	RNA polymerase activity
CB4_RS01135	COG2813	Specifically methylates the guanine in position
CB4_RS01140	COG0222	ribosome binding
CB4_RS01145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CB4_RS01155	COG0081	regulation of translation
CB4_RS01160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CB4_RS01165	COG0250	Participates in transcription elongation, termination and antitermination
CB4_RS01170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CB4_RS01175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CB4_RS01190	COG3688	RNA-binding protein containing a PIN domain
CB4_RS01195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CB4_RS01205	COG0215	cysteine-tRNA ligase activity
CB4_RS01210	COG1045	serine acetyltransferase
CB4_RS01215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CB4_RS01220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CB4_RS01230	COG4956	integral membrane protein (PIN domain superfamily)
CB4_RS01235	COG1329	Transcriptional regulator
CB4_RS01240	COG1183	phosphatidylcholine synthase activity
CB4_RS01245	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CB4_RS01250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CB4_RS01255	COG0542	response to heat
CB4_RS01260	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CB4_RS01265	COG3880	PFAM UvrB UvrC protein
CB4_RS01270	COG4463	regulation of RNA biosynthetic process
CB4_RS01275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CB4_RS01280	COG0581	inorganic phosphate transmembrane transporter activity
CB4_RS01285	COG0573	inorganic phosphate transmembrane transporter activity
CB4_RS01295	COG0840	transmembrane signaling receptor activity
CB4_RS01325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CB4_RS01335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CB4_RS01340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CB4_RS01345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CB4_RS01350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CB4_RS01355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CB4_RS01360	COG0512	Glutamine amidotransferase of anthranilate synthase
CB4_RS01365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CB4_RS01370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CB4_RS01380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CB4_RS01390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CB4_RS01395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CB4_RS01400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CB4_RS01405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CB4_RS01410	COG0037	tRNA processing
CB4_RS01425	COG2208	phosphoserine phosphatase activity
CB4_RS01430	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CB4_RS01445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CB4_RS01450	COG3956	TIGRFAM MazG family protein
CB4_RS01455	COG2244	polysaccharide biosynthetic process
CB4_RS01460	COG2002	toxin-antitoxin pair type II binding
CB4_RS01470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CB4_RS01480	COG0193	aminoacyl-tRNA hydrolase activity
CB4_RS01485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CB4_RS01490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CB4_RS01495	COG2088	sporulation resulting in formation of a cellular spore
CB4_RS01500	COG0251	oxidation-reduction process
CB4_RS01505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CB4_RS01510	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CB4_RS01520	COG4466	Protein conserved in bacteria
CB4_RS01530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CB4_RS01540	COG3584	3D domain protein
CB4_RS01540	COG1388	LysM domain
CB4_RS01545	COG0084	hydrolase, TatD family'
CB4_RS01555	COG2002	toxin-antitoxin pair type II binding
CB4_RS01560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CB4_RS01565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CB4_RS01570	COG4467	Involved in initiation control of chromosome replication
CB4_RS01575	COG1774	PSP1 C-terminal conserved region
CB4_RS01580	COG0470	DNA polymerase III
CB4_RS01585	COG1728	Protein conserved in bacteria
CB4_RS01590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CB4_RS01595	COG1982	Orn Lys Arg decarboxylase major
CB4_RS01635	COG1266	CAAX protease self-immunity
CB4_RS01640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CB4_RS01645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CB4_RS01650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CB4_RS01655	COG5002	protein histidine kinase activity
CB4_RS01685	COG1309	transcriptional regulator
CB4_RS01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB4_RS01700	COG0590	tRNA wobble adenosine to inosine editing
CB4_RS01715	COG2267	carboxylic ester hydrolase activity
CB4_RS01725	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_RS01730	COG1024	Enoyl-CoA hydratase
CB4_RS01735	COG3290	protein histidine kinase activity
CB4_RS01735	COG3829	transcription factor binding
CB4_RS01755	COG1587	Uroporphyrinogen-III synthase
CB4_RS01755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CB4_RS01785	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CB4_RS01810	COG2197	response regulator
CB4_RS01815	COG4585	Histidine kinase
CB4_RS01830	COG0427	acetyl-CoA hydrolase
CB4_RS01835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CB4_RS01845	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CB4_RS01855	COG0517	IMP dehydrogenase activity
CB4_RS01855	COG0516	GMP reductase activity
CB4_RS01880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CB4_RS01885	COG0187	DNA topoisomerase II activity
CB4_RS01895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CB4_RS01900	COG2501	S4 domain
CB4_RS01905	COG0592	DNA-directed DNA polymerase activity
CB4_RS01910	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CB4_RS01915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CB4_RS01920	COG0594	ribonuclease P activity
CB4_RS01925	COG0706	membrane insertase activity
CB4_RS01930	COG1847	R3H domain protein
CB4_RS01935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CB4_RS01940	COG0445	tRNA wobble uridine modification
CB4_RS01945	COG0357	Ribosomal RNA small subunit methyltransferase G
CB4_RS01950	COG1475	DNA binding
CB4_RS01955	COG1192	Involved in chromosome partitioning
CB4_RS01960	COG1475	DNA binding
CB4_RS01985	COG0668	transmembrane transport
CB4_RS01990	COG4481	Protein conserved in bacteria
CB4_RS01995	COG0012	GTP binding
CB4_RS02005	COG0629	single-stranded DNA binding
CB4_RS02010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CB4_RS02020	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CB4_RS02025	COG0359	binds to the 23S rRNA
CB4_RS02030	COG1372	Participates in initiation and elongation during chromosome replication
CB4_RS02030	COG0305	Participates in initiation and elongation during chromosome replication
CB4_RS02035	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CB4_RS02040	COG0739	heme binding
CB4_RS02045	COG0745	RESPONSE REGULATOR receiver
CB4_RS02050	COG5002	protein histidine kinase activity
CB4_RS02055	COG4863	YycH protein
CB4_RS02060	COG4853	Protein conserved in bacteria
CB4_RS02065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CB4_RS02070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB4_RS02080	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CB4_RS02090	COG4221	oxidoreductase activity
CB4_RS02105	COG4221	oxidoreductase activity
CB4_RS02115	COG0745	RESPONSE REGULATOR receiver
CB4_RS02115	COG2972	Histidine kinase
CB4_RS02120	COG3693	PFAM glycoside hydrolase, family 10
CB4_RS02125	COG1361	Conserved repeat domain
CB4_RS02125	COG2911	Protein conserved in bacteria
CB4_RS02125	COG3266	domain, Protein
CB4_RS02130	COG0697	spore germination
CB4_RS02150	COG1595	DNA-templated transcription, initiation
CB4_RS02165	COG0840	transmembrane signaling receptor activity
CB4_RS02170	COG0697	spore germination
CB4_RS02175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_RS02190	COG1346	cytolysis
CB4_RS02195	COG1380	Effector of murein hydrolase LrgA
CB4_RS02200	COG0583	DNA-binding transcription factor activity
CB4_RS02230	COG5002	protein histidine kinase activity
CB4_RS02240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CB4_RS02250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CB4_RS02255	COG0583	DNA-binding transcription factor activity
CB4_RS02265	COG4895	conserved protein (DUF2196)
CB4_RS02275	COG1643	Atp-dependent helicase
CB4_RS02280	COG2322	membrane
CB4_RS02290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CB4_RS02295	COG1845	cytochrome c oxidase, subunit III
CB4_RS02305	COG2186	Transcriptional regulator
CB4_RS02315	COG0559	Belongs to the binding-protein-dependent transport system permease family
CB4_RS02335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CB4_RS02340	COG0037	tRNA processing
CB4_RS02345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CB4_RS02350	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CB4_RS02360	COG0702	epimerase
CB4_RS02365	COG1801	Protein of unknown function DUF72
CB4_RS02370	COG0351	phosphomethylpyrimidine kinase
CB4_RS02375	COG0840	transmembrane signaling receptor activity
CB4_RS02380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CB4_RS02385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CB4_RS02385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CB4_RS02390	COG0450	alkyl hydroperoxide reductase
CB4_RS02395	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CB4_RS02400	COG0531	amino acid
CB4_RS02490	COG3853	Toxic anion resistance protein (TelA)
CB4_RS02495	COG2094	Belongs to the DNA glycosylase MPG family
CB4_RS02500	COG1234	tRNA 3'-trailer cleavage
CB4_RS02520	COG1151	hydroxylamine reductase activity
CB4_RS02540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CB4_RS02560	COG5001	Diguanylate cyclase
CB4_RS02560	COG3300	MHYT domain
CB4_RS02570	COG1192	Involved in chromosome partitioning
CB4_RS02580	COG4841	protein insertion into membrane
CB4_RS02585	COG0697	spore germination
CB4_RS02595	COG1131	(ABC) transporter
CB4_RS02615	COG2363	Small membrane protein
CB4_RS02630	COG1295	ribonuclease BN
CB4_RS02640	COG0726	polysaccharide deacetylase
CB4_RS02640	COG1649	PFAM Uncharacterised BCR, COG1649
CB4_RS02650	COG1131	(ABC) transporter
CB4_RS02655	COG4473	ABC transporter
CB4_RS02660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CB4_RS02670	COG0584	glycerophosphoryl diester phosphodiesterase
CB4_RS02675	COG1114	Component of the transport system for branched-chain amino acids
CB4_RS02680	COG0367	asparagine synthase
CB4_RS02690	COG4844	belongs to the
CB4_RS02700	COG0564	pseudouridine synthase activity
CB4_RS02705	COG1078	dGTPase activity
CB4_RS02715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CB4_RS02725	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CB4_RS02730	COG0010	Belongs to the arginase family
CB4_RS02740	COG0018	arginyl-trna synthetase
CB4_RS02750	COG2181	nitrate reductase activity
CB4_RS02750	COG0247	lactate metabolic process
CB4_RS02755	COG0183	Belongs to the thiolase family
CB4_RS02760	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_RS02765	COG1960	acyl-CoA dehydrogenase activity
CB4_RS02770	COG1960	acyl-CoA dehydrogenase activity
CB4_RS02775	COG1703	isobutyryl-CoA mutase activity
CB4_RS02785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CB4_RS02785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CB4_RS02785	COG1703	isobutyryl-CoA mutase activity
CB4_RS02790	COG3343	RNA polymerase activity
CB4_RS02800	COG2204	response regulator
CB4_RS02805	COG0191	fructose-bisphosphate aldolase activity
CB4_RS02810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CB4_RS02815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CB4_RS02820	COG1494	fructose-1,6-bisphosphatase
CB4_RS02825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CB4_RS02835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CB4_RS02845	COG0254	rRNA binding
CB4_RS02860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CB4_RS02865	COG2890	protein-(glutamine-N5) methyltransferase activity
CB4_RS02875	COG0009	L-threonylcarbamoyladenylate synthase
CB4_RS02880	COG1971	Probably functions as a manganese efflux pump
CB4_RS02890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CB4_RS02900	COG0698	ribose 5-phosphate isomerase
CB4_RS02905	COG4475	Protein of unknown function (DUF436)
CB4_RS02910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CB4_RS02915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CB4_RS02920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CB4_RS02950	COG0356	it plays a direct role in the translocation of protons across the membrane
CB4_RS02960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CB4_RS02965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CB4_RS02970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CB4_RS02975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CB4_RS02980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CB4_RS02985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CB4_RS02990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CB4_RS03005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB4_RS03010	COG0649	NAD binding
CB4_RS03015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CB4_RS03035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CB4_RS03040	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CB4_RS03045	COG1007	ATP synthesis coupled electron transport
CB4_RS03050	COG4836	Membrane
CB4_RS03060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CB4_RS03065	COG2385	sporulation resulting in formation of a cellular spore
CB4_RS03080	COG0739	heme binding
CB4_RS03085	COG1609	Transcriptional regulator
CB4_RS03095	COG4786	Flagellar basal body rod
CB4_RS03110	COG1522	sequence-specific DNA binding
CB4_RS03115	COG0436	Aminotransferase
CB4_RS03125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CB4_RS03140	COG1682	transport, permease protein
CB4_RS03150	COG2226	methyltransferase
CB4_RS03190	COG0463	Glycosyl transferase, family 2
CB4_RS03200	COG3246	L-lysine catabolic process to acetate
CB4_RS03205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CB4_RS03210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CB4_RS03230	COG1091	dTDP-4-dehydrorhamnose reductase activity
CB4_RS03235	COG1215	transferase activity, transferring glycosyl groups
CB4_RS03240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CB4_RS03270	COG1846	Transcriptional regulator
CB4_RS03275	COG1566	PFAM secretion protein HlyD family protein
CB4_RS03280	COG2814	Major facilitator Superfamily
CB4_RS03285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB4_RS03305	COG2911	Protein conserved in bacteria
CB4_RS03305	COG1361	Conserved repeat domain
CB4_RS03305	COG3266	domain, Protein
CB4_RS03335	COG0793	Belongs to the peptidase S41A family
CB4_RS03345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CB4_RS03355	COG2197	response regulator
CB4_RS03375	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CB4_RS03380	COG1040	competence protein
CB4_RS03385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CB4_RS03405	COG4786	Flagellar basal body rod
CB4_RS03405	COG1256	bacterial-type flagellum assembly
CB4_RS03410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CB4_RS03420	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CB4_RS03425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CB4_RS03455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CB4_RS03490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CB4_RS03495	COG0765	amino acid transport
CB4_RS03500	COG1278	Cold shock
CB4_RS03505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CB4_RS03510	COG0653	protein targeting
CB4_RS03520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_RS03525	COG3959	Transketolase, thiamine diphosphate binding domain
CB4_RS03530	COG3958	Transketolase
CB4_RS03545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CB4_RS03550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CB4_RS03555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CB4_RS03560	COG0505	Belongs to the CarA family
CB4_RS03565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CB4_RS03570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CB4_RS03580	COG1067	ATP-dependent peptidase activity
CB4_RS03585	COG0137	argininosuccinate synthase activity
CB4_RS03590	COG0165	Argininosuccinate lyase
CB4_RS03595	COG2884	Cell division ATP-binding protein ftsE
CB4_RS03600	COG2177	Part of the ABC transporter FtsEX involved in
CB4_RS03605	COG4942	peptidase
CB4_RS03610	COG3409	Peptidoglycan-binding domain 1 protein
CB4_RS03610	COG0793	Belongs to the peptidase S41A family
CB4_RS03615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB4_RS03630	COG0556	nucleotide-excision repair
CB4_RS03635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CB4_RS03640	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CB4_RS03650	COG0546	phosphoglycolate phosphatase activity
CB4_RS03655	COG0110	maltose O-acetyltransferase activity
CB4_RS03665	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CB4_RS03670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CB4_RS03675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CB4_RS03680	COG0131	Imidazoleglycerol-phosphate dehydratase
CB4_RS03685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CB4_RS03690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CB4_RS03695	COG0107	imidazoleglycerol-phosphate synthase activity
CB4_RS03705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CB4_RS03705	COG0140	phosphoribosyl-ATP diphosphatase activity
CB4_RS03710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CB4_RS03715	COG1522	sequence-specific DNA binding
CB4_RS03795	COG0492	ferredoxin-NADP+ reductase activity
CB4_RS03800	COG1660	Displays ATPase and GTPase activities
CB4_RS03805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CB4_RS03810	COG1481	regulation of sporulation
CB4_RS03815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CB4_RS03820	COG0740	serine-type endopeptidase activity
CB4_RS03845	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CB4_RS03860	COG0126	phosphoglycerate kinase activity
CB4_RS03865	COG0149	triose-phosphate isomerase activity
CB4_RS03875	COG0148	phosphopyruvate hydratase activity
CB4_RS03880	COG0735	belongs to the Fur family
CB4_RS03885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CB4_RS03895	COG1647	Serine aminopeptidase, S33
CB4_RS03900	COG0557	exoribonuclease II activity
CB4_RS03910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CB4_RS03925	COG3300	MHYT domain
CB4_RS03925	COG5001	Diguanylate cyclase
CB4_RS03930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_RS03940	COG3883	PFAM NLP P60 protein
CB4_RS03940	COG0791	NLP P60 protein
CB4_RS03950	COG1473	amidohydrolase
CB4_RS03955	COG2171	N-acyltransferase activity
CB4_RS03985	COG3829	transcription factor binding
CB4_RS03985	COG3290	protein histidine kinase activity
CB4_RS03990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CB4_RS04000	COG3321	synthase
CB4_RS04000	COG0604	alcohol dehydrogenase
CB4_RS04010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CB4_RS04030	COG0646	methionine synthase
CB4_RS04030	COG1410	methionine synthase
CB4_RS04035	COG0646	methionine synthase
CB4_RS04035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CB4_RS04040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CB4_RS04045	COG0726	polysaccharide deacetylase
CB4_RS04055	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CB4_RS04060	COG0494	nUDIX hydrolase
CB4_RS04065	COG1612	heme a metabolic process
CB4_RS04070	COG0109	protoheme IX farnesyltransferase activity
CB4_RS04075	COG1999	signal sequence binding
CB4_RS04095	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CB4_RS04095	COG2508	Transcriptional regulator
CB4_RS04100	COG0686	Belongs to the AlaDH PNT family
CB4_RS04135	COG1119	ATPase activity
CB4_RS04140	COG0277	FAD linked oxidase domain protein
CB4_RS04155	COG2268	Band 7 protein
CB4_RS04160	COG2404	hydrolase activity, acting on ester bonds
CB4_RS04165	COG1388	LysM domain
CB4_RS04165	COG3584	3D domain protein
CB4_RS04170	COG0482	sulfurtransferase activity
CB4_RS04175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CB4_RS04185	COG4846	Membrane protein involved in cytochrome C biogenesis
CB4_RS04190	COG2186	Transcriptional regulator
CB4_RS04195	COG1620	l-lactate permease
CB4_RS04200	COG0247	lactate metabolic process
CB4_RS04205	COG1139	Iron-sulfur cluster binding protein
CB4_RS04210	COG1556	Lactate utilization protein
CB4_RS04215	COG0697	spore germination
CB4_RS04235	COG1012	belongs to the aldehyde dehydrogenase family
CB4_RS04240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CB4_RS04245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CB4_RS04250	COG0477	Major facilitator Superfamily
CB4_RS04255	COG1492	cobalamin metabolic process
CB4_RS04265	COG0778	Nitroreductase
CB4_RS04270	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CB4_RS04275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CB4_RS04285	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CB4_RS04295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CB4_RS04305	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CB4_RS04320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CB4_RS04325	COG1739	Uncharacterized protein family UPF0029
CB4_RS04335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CB4_RS04390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CB4_RS04395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CB4_RS04400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CB4_RS04405	COG0697	spore germination
CB4_RS04435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CB4_RS04440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CB4_RS04445	COG1120	ATPase activity
CB4_RS04450	COG1393	Belongs to the ArsC family
CB4_RS04455	COG0436	Aminotransferase
CB4_RS04460	COG0450	alkyl hydroperoxide reductase
CB4_RS04600	COG0456	acetyltransferase
CB4_RS04620	COG0456	acetyltransferase
CB4_RS04660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB4_RS04665	COG0509	glycine decarboxylation via glycine cleavage system
CB4_RS04670	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CB4_RS04675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CB4_RS04680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CB4_RS04685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CB4_RS04700	COG1191	sigma factor activity
CB4_RS04705	COG2755	lipolytic protein G-D-S-L family
CB4_RS04710	COG0396	ATPase activity
CB4_RS04715	COG0719	Fe-S assembly protein
CB4_RS04720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CB4_RS04725	COG0822	iron-sulfur transferase activity
CB4_RS04730	COG0719	Fe-S assembly protein
CB4_RS04735	COG4974	Belongs to the 'phage' integrase family
CB4_RS04750	COG1917	Cupin 2, conserved barrel domain protein
CB4_RS04750	COG2207	Transcriptional regulator
CB4_RS04755	COG0697	spore germination
CB4_RS04770	COG0730	response to heat
CB4_RS04780	COG3377	Domain of unknown function (DUF1805)
CB4_RS04795	COG2208	phosphoserine phosphatase activity
CB4_RS04810	COG1366	Belongs to the anti-sigma-factor antagonist family
CB4_RS04820	COG0791	NLP P60 protein
CB4_RS04825	COG2205	protein histidine kinase activity
CB4_RS04830	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CB4_RS04835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CB4_RS04850	COG5609	conserved protein (DUF2294)
CB4_RS04895	COG1376	ErfK ybiS ycfS ynhG family protein
CB4_RS04900	COG0697	spore germination
CB4_RS04905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_RS04910	COG1233	COG1233 Phytoene dehydrogenase and related
CB4_RS04955	COG1376	ErfK ybiS ycfS ynhG family protein
CB4_RS04960	COG0739	heme binding
CB4_RS04965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CB4_RS04975	COG4470	Protein conserved in bacteria
CB4_RS04990	COG2445	Protein of unknown function DUF86
CB4_RS05005	COG0789	Transcriptional regulator
CB4_RS05010	COG0697	spore germination
CB4_RS05015	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CB4_RS05025	COG1129	ABC transporter
CB4_RS05030	COG4214	carbohydrate transport
CB4_RS05040	COG0647	UMP catabolic process
CB4_RS05055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CB4_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_RS05065	COG0494	nUDIX hydrolase
CB4_RS05070	COG0840	transmembrane signaling receptor activity
CB4_RS05080	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CB4_RS05085	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_RS05090	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_RS05095	COG0183	Belongs to the thiolase family
CB4_RS05100	COG0183	Belongs to the thiolase family
CB4_RS05125	COG0683	leucine binding
CB4_RS05130	COG3396	Phenylacetate-CoA oxygenase
CB4_RS05145	COG2151	metal-sulfur cluster biosynthetic enzyme
CB4_RS05150	COG1012	belongs to the aldehyde dehydrogenase family
CB4_RS05155	COG2814	Major facilitator Superfamily
CB4_RS05160	COG0583	DNA-binding transcription factor activity
CB4_RS05165	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CB4_RS05170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CB4_RS05175	COG0626	cystathionine gamma-synthase activity
CB4_RS05180	COG4837	Protein of unknown function (DUF1462)
CB4_RS05185	COG4844	belongs to the
CB4_RS05195	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CB4_RS05200	COG0316	Belongs to the HesB IscA family
CB4_RS05210	COG5001	Diguanylate cyclase
CB4_RS05210	COG3706	GGDEF domain
CB4_RS05210	COG4251	negative regulation of phosphorylation
CB4_RS05210	COG2203	Gaf domain
CB4_RS05250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CB4_RS05270	COG1252	NADH dehydrogenase
CB4_RS05280	COG3584	3D domain protein
CB4_RS05285	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CB4_RS05290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CB4_RS05295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CB4_RS05305	COG0028	Belongs to the TPP enzyme family
CB4_RS05310	COG0440	acetolactate synthase activity
CB4_RS05315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CB4_RS05320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CB4_RS05340	COG1401	restriction endodeoxyribonuclease activity
CB4_RS05350	COG1363	Peptidase, m42
CB4_RS05360	COG0569	domain protein
CB4_RS05365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CB4_RS05375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CB4_RS05380	COG0072	phenylalanine-tRNA ligase activity
CB4_RS05380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CB4_RS05385	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CB4_RS05390	COG1286	toxin biosynthetic process
CB4_RS05400	COG1193	negative regulation of DNA recombination
CB4_RS05405	COG3766	membrane
CB4_RS05410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CB4_RS05455	COG0297	glycogen (starch) synthase activity
CB4_RS05455	COG0438	transferase activity, transferring glycosyl groups
CB4_RS05460	COG0728	peptidoglycan biosynthetic process
CB4_RS05465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CB4_RS05475	COG1309	transcriptional regulator
CB4_RS05480	COG1024	Enoyl-CoA hydratase
CB4_RS05485	COG2086	electron transfer activity
CB4_RS05490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CB4_RS05495	COG0471	metal ion transport
CB4_RS05500	COG3118	belongs to the thioredoxin family
CB4_RS05510	COG0322	excinuclease ABC activity
CB4_RS05525	COG1268	BioY protein
CB4_RS05530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CB4_RS05535	COG2009	succinate dehydrogenase
CB4_RS05540	COG1053	succinate dehydrogenase
CB4_RS05545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CB4_RS05550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CB4_RS05555	COG0824	Thioesterase
CB4_RS05565	COG2197	response regulator
CB4_RS05580	COG5401	PFAM Sporulation and spore germination
CB4_RS05585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CB4_RS05590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CB4_RS05605	COG0544	peptidyl-prolyl cis-trans isomerase activity
CB4_RS05610	COG0740	serine-type endopeptidase activity
CB4_RS05615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CB4_RS05625	COG0470	DNA polymerase III
CB4_RS05625	COG1067	ATP-dependent peptidase activity
CB4_RS05635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CB4_RS05640	COG0697	spore germination
CB4_RS05655	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CB4_RS05660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CB4_RS05665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CB4_RS05680	COG0113	porphobilinogen synthase activity
CB4_RS05685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CB4_RS05710	COG0525	valine-tRNA ligase activity
CB4_RS05715	COG0285	dihydrofolate synthase activity
CB4_RS05720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CB4_RS05755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CB4_RS05765	COG1459	type II secretion system
CB4_RS05775	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CB4_RS05800	COG0424	maF-like protein
CB4_RS05805	COG2003	Belongs to the UPF0758 family
CB4_RS05810	COG1077	Cell shape determining protein MreB Mrl
CB4_RS05815	COG1792	Involved in formation and maintenance of cell shape
CB4_RS05825	COG0850	regulation of cytokinetic process
CB4_RS05830	COG2894	cell division
CB4_RS05835	COG0772	Belongs to the SEDS family
CB4_RS05845	COG1994	Peptidase M50
CB4_RS05855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CB4_RS05860	COG2868	ribosomal protein
CB4_RS05865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CB4_RS05875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CB4_RS05885	COG0586	Pfam SNARE associated Golgi protein
CB4_RS05890	COG4492	Belongs to the UPF0735 family
CB4_RS05895	COG0460	homoserine dehydrogenase
CB4_RS05900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CB4_RS05905	COG0083	homoserine kinase activity
CB4_RS05910	COG0077	Prephenate dehydratase
CB4_RS05930	COG0632	four-way junction helicase activity
CB4_RS05935	COG2255	four-way junction helicase activity
CB4_RS05950	COG2385	sporulation resulting in formation of a cellular spore
CB4_RS05955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CB4_RS05960	COG0343	queuine tRNA-ribosyltransferase activity
CB4_RS05965	COG1862	Preprotein translocase
CB4_RS05970	COG0531	amino acid
CB4_RS05980	COG2244	polysaccharide biosynthetic process
CB4_RS05995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CB4_RS05995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CB4_RS06000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CB4_RS06005	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CB4_RS06010	COG1490	D-aminoacyl-tRNA deacylase activity
CB4_RS06025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CB4_RS06030	COG0124	histidyl-tRNA synthetase
CB4_RS06035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CB4_RS06045	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CB4_RS06055	COG1959	2 iron, 2 sulfur cluster binding
CB4_RS06060	COG1104	cysteine desulfurase activity
CB4_RS06085	COG0840	transmembrane signaling receptor activity
CB4_RS06095	COG0628	permease
CB4_RS06105	COG4472	Bacterial protein of unknown function (DUF965)
CB4_RS06110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CB4_RS06115	COG3906	Belongs to the UPF0473 family
CB4_RS06120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CB4_RS06125	COG4122	O-methyltransferase activity
CB4_RS06130	COG0826	peptidase U32
CB4_RS06135	COG0826	peptidase U32
CB4_RS06140	COG0768	penicillin binding
CB4_RS06145	COG0671	phosphoesterase, PA-phosphatase related
CB4_RS06150	COG3253	May function as heme-dependent peroxidase
CB4_RS06155	COG3876	Protein conserved in bacteria
CB4_RS06165	COG3853	Toxic anion resistance protein (TelA)
CB4_RS06205	COG1215	transferase activity, transferring glycosyl groups
CB4_RS06215	COG0745	RESPONSE REGULATOR receiver
CB4_RS06220	COG5002	protein histidine kinase activity
CB4_RS06235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CB4_RS06250	COG0393	Putative heavy-metal-binding
CB4_RS06280	COG4221	oxidoreductase activity
CB4_RS06285	COG3177	Filamentation induced by cAMP protein fic
CB4_RS06320	COG2733	membrane
CB4_RS06325	COG2733	membrane
CB4_RS06350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CB4_RS06375	COG1361	Conserved repeat domain
CB4_RS06375	COG2911	Protein conserved in bacteria
CB4_RS06375	COG3266	domain, Protein
CB4_RS06385	COG1278	Cold shock
CB4_RS06405	COG1027	Aspartate ammonia-lyase
CB4_RS06415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CB4_RS06420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CB4_RS06425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CB4_RS06430	COG1876	peptidase activity
CB4_RS06465	COG0840	transmembrane signaling receptor activity
CB4_RS06465	COG3290	protein histidine kinase activity
CB4_RS06475	COG3949	Membrane
CB4_RS06480	COG0681	Belongs to the peptidase S26 family
CB4_RS06495	COG0022	dehydrogenase e1 component
CB4_RS06500	COG0508	dehydrogenase complex catalyzes the overall conversion of
CB4_RS06510	COG0840	transmembrane signaling receptor activity
CB4_RS06515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CB4_RS06525	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CB4_RS06530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CB4_RS06535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CB4_RS06540	COG1534	Rna-binding protein
CB4_RS06545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CB4_RS06550	COG1713	HD superfamily hydrolase involved in NAD metabolism
CB4_RS06555	COG0799	negative regulation of ribosome biogenesis
CB4_RS06560	COG2226	methyltransferase
CB4_RS06565	COG0495	leucyl-tRNA aminoacylation
CB4_RS06575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CB4_RS06610	COG0658	competence protein
CB4_RS06610	COG2333	competence protein COMEC
CB4_RS06615	COG1595	DNA-templated transcription, initiation
CB4_RS06625	COG1466	dna polymerase III delta subunit
CB4_RS06630	COG0268	Binds directly to 16S ribosomal RNA
CB4_RS06640	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_RS06650	COG0006	proline dipeptidase activity
CB4_RS06665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CB4_RS06670	COG1420	regulation of RNA biosynthetic process
CB4_RS06675	COG0459	protein refolding
CB4_RS06685	COG0443	Heat shock 70 kDa protein
CB4_RS06690	COG0484	heat shock protein binding
CB4_RS06695	COG2264	protein methyltransferase activity
CB4_RS06700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CB4_RS06705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CB4_RS06715	COG3290	protein histidine kinase activity
CB4_RS06720	COG4565	transcriptional regulatory protein
CB4_RS06725	COG1301	dicarboxylic acid transport
CB4_RS06730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CB4_RS06740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CB4_RS06745	COG0515	serine threonine protein kinase
CB4_RS06745	COG2815	serine threonine protein kinase
CB4_RS06760	COG0484	heat shock protein binding
CB4_RS06940	COG1283	sodium-dependent phosphate transmembrane transporter activity
CB4_RS06950	COG0741	lytic transglycosylase activity
CB4_RS06975	COG0840	transmembrane signaling receptor activity
CB4_RS06975	COG5278	phosphoserine phosphatase activity
CB4_RS06980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CB4_RS06985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_RS07015	COG1278	Cold shock
CB4_RS07020	COG2733	membrane
CB4_RS07025	COG4191	Histidine kinase
CB4_RS07030	COG0784	Response regulator, receiver
CB4_RS07035	COG1181	Belongs to the D-alanine--D-alanine ligase family
CB4_RS07040	COG0583	DNA-binding transcription factor activity
CB4_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_RS07050	COG3011	Protein conserved in bacteria
CB4_RS07055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CB4_RS07060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CB4_RS07065	COG1610	YqeY-like protein
CB4_RS07090	COG1702	phosphate starvation-inducible protein PhoH
CB4_RS07095	COG1480	7TM receptor with intracellular HD hydrolase
CB4_RS07100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CB4_RS07105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CB4_RS07110	COG0295	cytidine deaminase activity
CB4_RS07115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CB4_RS07125	COG1381	Involved in DNA repair and RecF pathway recombination
CB4_RS07130	COG0752	glycyl-tRNA synthetase alpha subunit
CB4_RS07135	COG0751	glycine-tRNA ligase activity
CB4_RS07140	COG0517	IMP dehydrogenase activity
CB4_RS07145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CB4_RS07150	COG0358	DNA primase activity
CB4_RS07155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CB4_RS07165	COG1960	acyl-CoA dehydrogenase activity
CB4_RS07170	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_RS07180	COG2384	SAM-dependent methyltransferase
CB4_RS07185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CB4_RS07205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CB4_RS07215	COG0312	modulator of DNA gyrase
CB4_RS07220	COG0312	modulator of DNA gyrase
CB4_RS07225	COG2827	Endonuclease containing a URI domain
CB4_RS07235	COG4106	trans-aconitate 2-methyltransferase activity
CB4_RS07275	COG0531	amino acid
CB4_RS07290	COG2070	2-Nitropropane dioxygenase
CB4_RS07305	COG0310	cobalt ion transport
CB4_RS07310	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CB4_RS07320	COG1122	ATPase activity
CB4_RS07345	COG0523	cobalamin synthesis protein
CB4_RS07355	COG0701	Predicted permease
CB4_RS07360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CB4_RS07380	COG0584	glycerophosphoryl diester phosphodiesterase
CB4_RS07395	COG0004	ammonium transporteR
CB4_RS07400	COG1733	regulation of RNA biosynthetic process
CB4_RS07415	COG2326	polyphosphate kinase activity
CB4_RS07420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CB4_RS07430	COG1114	Component of the transport system for branched-chain amino acids
CB4_RS07450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_RS07460	COG1116	anion transmembrane transporter activity
CB4_RS07465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CB4_RS07470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CB4_RS07475	COG0351	phosphomethylpyrimidine kinase
CB4_RS07490	COG0840	transmembrane signaling receptor activity
CB4_RS07500	COG1607	acyl-coa hydrolase
CB4_RS07510	COG0390	transport system, permease component
CB4_RS07515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CB4_RS07520	COG0705	Rhomboid family
CB4_RS07520	COG0457	Tetratricopeptide repeat
CB4_RS07530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CB4_RS07545	COG1363	Peptidase, m42
CB4_RS07555	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_RS07560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CB4_RS07565	COG0387	Pfam Sodium calcium exchanger
CB4_RS07575	COG0640	Transcriptional regulator
CB4_RS07590	COG2050	protein possibly involved in aromatic compounds catabolism
CB4_RS07605	COG4471	UPF0298 protein
CB4_RS07610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_RS07610	COG2199	diguanylate cyclase activity
CB4_RS07615	COG0589	response to stress
CB4_RS07635	COG2165	general secretion pathway protein
CB4_RS07660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CB4_RS07675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CB4_RS07695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CB4_RS07700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CB4_RS07705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CB4_RS07710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CB4_RS07715	COG0095	Lipoate-protein ligase
CB4_RS07730	COG0579	oxidoreductase
CB4_RS07745	COG2824	Alkylphosphonate utilization operon protein PhnA
CB4_RS07750	COG0745	RESPONSE REGULATOR receiver
CB4_RS07750	COG2972	Histidine kinase
CB4_RS07760	COG0596	Alpha beta hydrolase
CB4_RS07765	COG3290	protein histidine kinase activity
CB4_RS07765	COG0840	transmembrane signaling receptor activity
CB4_RS07785	COG0277	FAD linked oxidase domain protein
CB4_RS07790	COG0247	lactate metabolic process
CB4_RS07795	COG0789	Transcriptional regulator
CB4_RS07830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB4_RS07840	COG1666	GTP binding
CB4_RS07845	COG1321	iron dependent repressor
CB4_RS07850	COG1752	Esterase of the alpha-beta hydrolase superfamily
CB4_RS07860	COG3872	metal-dependent enzyme
CB4_RS07870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CB4_RS07875	COG0006	proline dipeptidase activity
CB4_RS07880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CB4_RS07885	COG0840	transmembrane signaling receptor activity
CB4_RS07885	COG3290	protein histidine kinase activity
CB4_RS07890	COG3854	ATPases associated with a variety of cellular activities
CB4_RS07930	COG0511	ligase activity, forming carbon-carbon bonds
CB4_RS07935	COG0439	Biotin carboxylase
CB4_RS07940	COG1302	Protein conserved in bacteria
CB4_RS07955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CB4_RS07960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CB4_RS07965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CB4_RS07970	COG1570	exodeoxyribonuclease VII activity
CB4_RS07975	COG1722	exodeoxyribonuclease VII activity
CB4_RS07985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CB4_RS07990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CB4_RS07995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CB4_RS08000	COG1438	arginine binding
CB4_RS08005	COG0497	DNA recombination
CB4_RS08010	COG0750	zinc metalloprotease
CB4_RS08015	COG0745	RESPONSE REGULATOR receiver
CB4_RS08025	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CB4_RS08030	COG0613	PHP domain protein
CB4_RS08040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CB4_RS08080	COG1982	Orn Lys Arg decarboxylase major
CB4_RS08090	COG4493	Belongs to the UPF0637 family
CB4_RS08100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CB4_RS08110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CB4_RS08120	COG3290	protein histidine kinase activity
CB4_RS08120	COG3829	transcription factor binding
CB4_RS08135	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CB4_RS08140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB4_RS08160	COG1393	Belongs to the ArsC family
CB4_RS08165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CB4_RS08170	COG1024	Enoyl-CoA hydratase
CB4_RS08180	COG0439	Biotin carboxylase
CB4_RS08185	COG0511	ligase activity, forming carbon-carbon bonds
CB4_RS08190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CB4_RS08195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CB4_RS08200	COG1309	transcriptional regulator
CB4_RS08205	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CB4_RS08210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CB4_RS08215	COG0275	rRNA processing
CB4_RS08225	COG0768	penicillin binding
CB4_RS08230	COG0768	penicillin binding
CB4_RS08235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CB4_RS08240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CB4_RS08245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CB4_RS08250	COG0772	Belongs to the SEDS family
CB4_RS08255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CB4_RS08260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CB4_RS08270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CB4_RS08285	COG3856	small basic protein
CB4_RS08290	COG0849	cell division
CB4_RS08295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CB4_RS08300	COG3647	Membrane
CB4_RS08310	COG1191	sigma factor activity
CB4_RS08315	COG1191	sigma factor activity
CB4_RS08325	COG1873	PFAM PRC-barrel domain
CB4_RS08335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CB4_RS08340	COG1799	cell septum assembly
CB4_RS08345	COG0762	integral membrane protein
CB4_RS08350	COG2302	S4 RNA-binding domain
CB4_RS08355	COG3599	regulation of cell shape
CB4_RS08360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CB4_RS08365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CB4_RS08370	COG0564	pseudouridine synthase activity
CB4_RS08385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CB4_RS08390	COG0505	Belongs to the CarA family
CB4_RS08395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CB4_RS08400	COG0543	2 iron, 2 sulfur cluster binding
CB4_RS08405	COG0167	dihydroorotate dehydrogenase activity
CB4_RS08430	COG2244	polysaccharide biosynthetic process
CB4_RS08445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CB4_RS08450	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CB4_RS08455	COG1561	YicC-like family, N-terminal region
CB4_RS08460	COG2052	Domain of unknown function (DUF370)
CB4_RS08465	COG0194	GDP metabolic process
CB4_RS08475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CB4_RS08480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CB4_RS08485	COG0242	peptide deformylase activity
CB4_RS08490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CB4_RS08495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CB4_RS08495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CB4_RS08500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CB4_RS08505	COG0631	protein serine/threonine phosphatase activity
CB4_RS08510	COG2815	serine threonine protein kinase
CB4_RS08510	COG0515	serine threonine protein kinase
CB4_RS08520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CB4_RS08530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CB4_RS08535	COG1302	Protein conserved in bacteria
CB4_RS08540	COG1461	Dihydroxyacetone kinase
CB4_RS08545	COG1307	EDD domain protein, DegV family
CB4_RS08550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CB4_RS08555	COG1285	pathogenesis
CB4_RS08560	COG0742	ribosomal rna small subunit methyltransferase
CB4_RS08565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CB4_RS08570	COG3314	Sporulation integral membrane protein YlbJ
CB4_RS08575	COG1752	Esterase of the alpha-beta hydrolase superfamily
CB4_RS08580	COG3480	Lon protease (S16) C-terminal proteolytic domain
CB4_RS08585	COG1323	Belongs to the UPF0348 family
CB4_RS08595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CB4_RS08605	COG0416	fatty acid biosynthetic process
CB4_RS08615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CB4_RS08620	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_RS08625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CB4_RS08630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CB4_RS08635	COG0571	ribonuclease III activity
CB4_RS08645	COG1196	nuclear chromosome segregation
CB4_RS08650	COG0552	protein localization to endoplasmic reticulum
CB4_RS08655	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CB4_RS08660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CB4_RS08670	COG1837	Belongs to the UPF0109 family
CB4_RS08680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CB4_RS08685	COG0336	Belongs to the RNA methyltransferase TrmD family
CB4_RS08690	COG0335	large ribosomal subunit rRNA binding
CB4_RS08695	COG0681	Belongs to the peptidase S26 family
CB4_RS08705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CB4_RS08715	COG2257	FlhB HrpN YscU SpaS Family
CB4_RS08720	COG0792	nuclease activity
CB4_RS08760	COG1396	sequence-specific DNA binding
CB4_RS08820	COG1484	DNA-dependent DNA replication
CB4_RS08830	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CB4_RS09020	COG0606	chelatase, subunit chli
CB4_RS09030	COG0045	succinate-CoA ligase (ADP-forming) activity
CB4_RS09035	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CB4_RS09040	COG0758	DNA mediated transformation
CB4_RS09045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CB4_RS09050	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CB4_RS09055	COG4974	Belongs to the 'phage' integrase family
CB4_RS09060	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CB4_RS09065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CB4_RS09070	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CB4_RS09075	COG1815	bacterial-type flagellum-dependent cell motility
CB4_RS09080	COG1558	bacterial-type flagellum-dependent cell motility
CB4_RS09085	COG1677	Flagellar hook-basal body complex protein FliE
CB4_RS09090	COG1766	The M ring may be actively involved in energy transduction
CB4_RS09095	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CB4_RS09105	COG1157	protein secretion by the type III secretion system
CB4_RS09120	COG3144	bacterial-type flagellum assembly
CB4_RS09125	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CB4_RS09135	COG4786	Flagellar basal body rod
CB4_RS09150	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CB4_RS09155	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CB4_RS09155	COG1776	CheC inhibitor of MCP methylation
CB4_RS09160	COG2201	protein-glutamate methylesterase activity
CB4_RS09165	COG3190	flagellar
CB4_RS09170	COG1338	Plays a role in the flagellum-specific transport system
CB4_RS09175	COG1987	bacterial-type flagellum assembly
CB4_RS09180	COG1684	flagellar biosynthetic protein fliR
CB4_RS09185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CB4_RS09190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CB4_RS09195	COG1419	protein localization to endoplasmic reticulum
CB4_RS09200	COG0455	bacterial-type flagellum organization
CB4_RS09205	COG2201	protein-glutamate methylesterase activity
CB4_RS09210	COG2201	protein-glutamate methylesterase activity
CB4_RS09215	COG0643	Histidine kinase
CB4_RS09215	COG2198	Histidine kinase
CB4_RS09220	COG0835	chemotaxis
CB4_RS09225	COG1776	CheC inhibitor of MCP methylation
CB4_RS09230	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CB4_RS09240	COG1191	sigma factor activity
CB4_RS09260	COG0052	Belongs to the universal ribosomal protein uS2 family
CB4_RS09265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CB4_RS09270	COG0528	UMP kinase activity
CB4_RS09275	COG0233	cytoplasmic translational termination
CB4_RS09280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CB4_RS09285	COG4589	Belongs to the CDS family
CB4_RS09295	COG0750	zinc metalloprotease
CB4_RS09300	COG0442	prolyl-tRNA aminoacylation
CB4_RS09305	COG2176	DNA-directed DNA polymerase activity
CB4_RS09310	COG0779	Required for maturation of 30S ribosomal subunits
CB4_RS09315	COG0195	Participates in both transcription termination and antitermination
CB4_RS09320	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CB4_RS09325	COG1358	cellular component organization or biogenesis
CB4_RS09330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CB4_RS09335	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CB4_RS09340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CB4_RS09345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CB4_RS09350	COG0196	riboflavin kinase activity
CB4_RS09360	COG1185	polyribonucleotide nucleotidyltransferase activity
CB4_RS09365	COG0726	polysaccharide deacetylase
CB4_RS09370	COG0612	Peptidase, M16
CB4_RS09375	COG0756	dUTP diphosphatase activity
CB4_RS09385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_RS09395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CB4_RS09430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CB4_RS09435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CB4_RS09440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CB4_RS09445	COG0527	aspartate kinase activity
CB4_RS09450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CB4_RS09455	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CB4_RS09460	COG0582	viral genome integration into host DNA
CB4_RS09475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CB4_RS09495	COG1657	PFAM Prenyltransferase squalene oxidase
CB4_RS09530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CB4_RS09575	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CB4_RS09575	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CB4_RS09580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CB4_RS09585	COG0431	NADPH-dependent FMN reductase
CB4_RS09590	COG0596	Alpha beta hydrolase
CB4_RS09595	COG1361	Conserved repeat domain
CB4_RS09605	COG2197	response regulator
CB4_RS09630	COG2814	Major facilitator Superfamily
CB4_RS09640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CB4_RS09645	COG4191	Histidine kinase
CB4_RS09655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CB4_RS09660	COG1272	protein, Hemolysin III
CB4_RS09675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CB4_RS09690	COG1714	RDD family
CB4_RS09705	COG0772	Belongs to the SEDS family
CB4_RS09725	COG1388	LysM domain
CB4_RS09725	COG0791	NLP P60 protein
CB4_RS09730	COG0730	response to heat
CB4_RS09735	COG1902	pentaerythritol trinitrate reductase activity
CB4_RS09740	COG1959	2 iron, 2 sulfur cluster binding
CB4_RS09750	COG0436	Aminotransferase
CB4_RS09755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_RS09760	COG3186	Phenylalanine-4-hydroxylase
CB4_RS09765	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CB4_RS09770	COG0501	Belongs to the peptidase M48B family
CB4_RS09775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CB4_RS09785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CB4_RS09790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CB4_RS09795	COG1842	Phage shock protein A
CB4_RS09810	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_RS09825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CB4_RS09830	COG1984	allophanate hydrolase subunit 2
CB4_RS09835	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CB4_RS09840	COG3290	protein histidine kinase activity
CB4_RS09840	COG3829	transcription factor binding
CB4_RS09845	COG1960	acyl-CoA dehydrogenase activity
CB4_RS09850	COG0183	Belongs to the thiolase family
CB4_RS09870	COG0024	Methionine aminopeptidase
CB4_RS09875	COG0745	RESPONSE REGULATOR receiver
CB4_RS09875	COG2972	Histidine kinase
CB4_RS09880	COG2972	Histidine kinase
CB4_RS09880	COG0745	RESPONSE REGULATOR receiver
CB4_RS09885	COG2368	4-hydroxyphenylacetate
CB4_RS09890	COG0531	amino acid
CB4_RS09895	COG1309	transcriptional regulator
CB4_RS09900	COG2814	Major facilitator Superfamily
CB4_RS09905	COG1846	Transcriptional regulator
CB4_RS09915	COG3885	ferrous iron binding
CB4_RS09915	COG2078	PFAM AMMECR1 domain protein
CB4_RS09920	COG0174	glutamine synthetase
CB4_RS09925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CB4_RS09935	COG0179	Fumarylacetoacetate (FAA) hydrolase
CB4_RS09955	COG2608	mercury ion transmembrane transporter activity
CB4_RS09960	COG2217	Heavy metal translocating P-type atpase
CB4_RS09965	COG0655	NAD(P)H dehydrogenase (quinone) activity
CB4_RS09975	COG2153	protein acetylation
CB4_RS09980	COG1846	Transcriptional regulator
CB4_RS09985	COG0745	RESPONSE REGULATOR receiver
CB4_RS09990	COG2770	Histidine kinase
CB4_RS09990	COG2205	protein histidine kinase activity
CB4_RS10010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CB4_RS10055	COG0189	ligase activity
CB4_RS10060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CB4_RS10075	COG0577	efflux transmembrane transporter activity
CB4_RS10085	COG0577	efflux transmembrane transporter activity
CB4_RS10085	COG1136	(ABC) transporter
CB4_RS10105	COG1012	belongs to the aldehyde dehydrogenase family
CB4_RS10115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB4_RS10120	COG2112	serine threonine protein kinase
CB4_RS10145	COG1177	transmembrane transport
CB4_RS10155	COG1349	DNA-binding transcription factor activity
CB4_RS10160	COG0561	phosphatase activity
CB4_RS10165	COG2076	Multidrug Resistance protein
CB4_RS10170	COG2076	Multidrug Resistance protein
CB4_RS10190	COG1131	(ABC) transporter
CB4_RS10205	COG2373	Large extracellular alpha-helical protein
CB4_RS10210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CB4_RS10225	COG1950	PFAM Membrane protein of
CB4_RS10245	COG0586	Pfam SNARE associated Golgi protein
CB4_RS10255	COG0740	serine-type endopeptidase activity
CB4_RS10290	COG0517	IMP dehydrogenase activity
CB4_RS10295	COG1164	Oligoendopeptidase f
CB4_RS10305	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CB4_RS10315	COG0745	RESPONSE REGULATOR receiver
CB4_RS10320	COG5002	protein histidine kinase activity
CB4_RS10350	COG0427	acetyl-CoA hydrolase
CB4_RS10355	COG0210	DNA helicase
CB4_RS10360	COG2996	Protein conserved in bacteria
CB4_RS10390	COG0791	NLP P60 protein
CB4_RS10390	COG1388	LysM domain
CB4_RS10395	COG0653	protein targeting
CB4_RS10405	COG1250	3-hydroxyacyl-CoA dehydrogenase
CB4_RS10405	COG1024	Enoyl-CoA hydratase
CB4_RS10410	COG0183	Belongs to the thiolase family
CB4_RS10415	COG1960	acyl-CoA dehydrogenase activity
CB4_RS10420	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_RS10430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CB4_RS10440	COG1164	Oligoendopeptidase f
CB4_RS10455	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_RS10460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_RS10480	COG2962	Rard protein
CB4_RS10485	COG1388	LysM domain
CB4_RS10485	COG3858	chitin binding
CB4_RS10495	COG1329	Transcriptional regulator
CB4_RS10525	COG3858	chitin binding
CB4_RS10525	COG1388	LysM domain
CB4_RS10530	COG2261	transglycosylase associated protein
CB4_RS10535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB4_RS10540	COG0116	Belongs to the methyltransferase superfamily
CB4_RS10570	COG4637	Psort location Cytoplasmic, score
CB4_RS10580	COG1309	transcriptional regulator
CB4_RS10585	COG1233	COG1233 Phytoene dehydrogenase and related
CB4_RS10590	COG2204	response regulator
CB4_RS10615	COG0506	proline dehydrogenase activity
CB4_RS10620	COG0517	IMP dehydrogenase activity
CB4_RS10630	COG0316	Belongs to the HesB IscA family
CB4_RS10635	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CB4_RS10640	COG0352	thiamine-phosphate diphosphorylase activity
CB4_RS10645	COG0187	DNA topoisomerase II activity
CB4_RS10650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CB4_RS10655	COG1098	S1 RNA binding domain
CB4_RS10660	COG0540	Belongs to the ATCase OTCase family
CB4_RS10665	COG1309	transcriptional regulator
CB4_RS10670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CB4_RS10670	COG2124	cytochrome p450
CB4_RS10680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CB4_RS10715	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CB4_RS10720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CB4_RS10730	COG0589	response to stress
CB4_RS10735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CB4_RS10745	COG0066	3-isopropylmalate dehydratase activity
CB4_RS10750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CB4_RS10755	COG0583	DNA-binding transcription factor activity
CB4_RS10765	COG0697	spore germination
CB4_RS10775	COG2002	toxin-antitoxin pair type II binding
CB4_RS10795	COG3437	response regulator, receiver
CB4_RS10795	COG0784	Response regulator, receiver
CB4_RS10800	COG1199	ATP-dependent helicase activity
CB4_RS10815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CB4_RS10830	COG2002	toxin-antitoxin pair type II binding
CB4_RS10835	COG1309	transcriptional regulator
CB4_RS10860	COG1090	epimerase
CB4_RS10865	COG0667	Aldo Keto reductase
CB4_RS10880	COG3858	chitin binding
CB4_RS10890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB4_RS10895	COG0697	spore germination
CB4_RS10900	COG2223	nitrite transmembrane transporter activity
CB4_RS10910	COG2391	methyltransferase activity
CB4_RS10915	COG3739	integral membrane protein
CB4_RS10925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CB4_RS10935	COG1115	amino acid carrier protein
CB4_RS10945	COG4191	Histidine kinase
CB4_RS10950	COG0784	Response regulator, receiver
CB4_RS10955	COG0640	Transcriptional regulator
CB4_RS10960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CB4_RS10965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CB4_RS10990	COG4106	trans-aconitate 2-methyltransferase activity
CB4_RS10995	COG1346	cytolysis
CB4_RS11000	COG1380	Effector of murein hydrolase LrgA
CB4_RS11025	COG1842	Phage shock protein A
CB4_RS11035	COG4585	Histidine kinase
CB4_RS11040	COG2197	response regulator
CB4_RS11045	COG5002	protein histidine kinase activity
CB4_RS11075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_RS11080	COG1979	alcohol dehydrogenase
CB4_RS11090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CB4_RS11095	COG4129	membrane
CB4_RS11105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB4_RS11105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB4_RS11110	COG2210	Belongs to the sulfur carrier protein TusA family
CB4_RS11115	COG0425	Belongs to the sulfur carrier protein TusA family
CB4_RS11115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB4_RS11120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CB4_RS11140	COG1459	type II secretion system
CB4_RS11170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CB4_RS11180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CB4_RS11185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CB4_RS11190	COG0489	protein tyrosine kinase activity
CB4_RS11200	COG0297	glycogen (starch) synthase activity
CB4_RS11210	COG0297	glycogen (starch) synthase activity
CB4_RS11230	COG0438	transferase activity, transferring glycosyl groups
CB4_RS11235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CB4_RS11255	COG0488	(ABC) transporter
CB4_RS11270	COG0328	RNA-DNA hybrid ribonuclease activity
CB4_RS11275	COG0527	aspartate kinase activity
CB4_RS11305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_RS11370	COG2003	Belongs to the UPF0758 family
CB4_RS11635	COG4974	Belongs to the 'phage' integrase family
CB4_RS11670	COG0419	ATPase involved in DNA repair
CB4_RS11680	COG0629	single-stranded DNA binding
CB4_RS11870	COG2359	stage V sporulation protein S
CB4_RS11875	COG1191	sigma factor activity
CB4_RS11895	COG1876	peptidase activity
CB4_RS11920	COG0270	DNA (cytosine-5-)-methyltransferase activity
CB4_RS11995	COG1113	amino acid transport
CB4_RS12000	COG0833	amino acid
CB4_RS12005	COG1113	amino acid transport
CB4_RS12060	COG2871	sodium ion transport
CB4_RS12120	COG0697	spore germination
CB4_RS12130	COG1902	pentaerythritol trinitrate reductase activity
CB4_RS12145	COG0583	DNA-binding transcription factor activity
CB4_RS12155	COG0179	Fumarylacetoacetate (FAA) hydrolase
CB4_RS12170	COG2860	membrane
CB4_RS12185	COG0791	NLP P60 protein
CB4_RS12215	COG0840	transmembrane signaling receptor activity
CB4_RS12220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_RS12225	COG2076	Multidrug Resistance protein
CB4_RS12230	COG2076	Multidrug Resistance protein
CB4_RS12240	COG2814	Major facilitator Superfamily
CB4_RS12245	COG0154	amidase activity
CB4_RS12255	COG1278	Cold shock
CB4_RS12260	COG0513	Belongs to the DEAD box helicase family
CB4_RS12265	COG1329	Transcriptional regulator
CB4_RS12275	COG0671	phosphoesterase, PA-phosphatase related
CB4_RS12280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CB4_RS12285	COG0586	Pfam SNARE associated Golgi protein
CB4_RS12290	COG1131	(ABC) transporter
CB4_RS12295	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CB4_RS12310	COG3150	esterase
CB4_RS12315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CB4_RS12325	COG0789	Transcriptional regulator
CB4_RS12325	COG4978	Transcriptional regulator
CB4_RS12330	COG2814	Major facilitator Superfamily
CB4_RS12335	COG0697	spore germination
CB4_RS12340	COG0531	amino acid
CB4_RS12350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CB4_RS12355	COG4086	secreted protein
CB4_RS12360	COG0460	homoserine dehydrogenase
CB4_RS12370	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CB4_RS12375	COG0427	acetyl-CoA hydrolase
CB4_RS12390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CB4_RS12405	COG2815	serine threonine protein kinase
CB4_RS12405	COG0515	serine threonine protein kinase
CB4_RS12420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CB4_RS12435	COG0322	excinuclease ABC activity
CB4_RS12440	COG0521	Mo-molybdopterin cofactor biosynthetic process
CB4_RS12465	COG1695	Transcriptional regulator
CB4_RS12470	COG0772	Belongs to the SEDS family
CB4_RS12475	COG0745	RESPONSE REGULATOR receiver
CB4_RS12480	COG5002	protein histidine kinase activity
CB4_RS12485	COG2132	Multicopper oxidase
CB4_RS12490	COG1136	(ABC) transporter
CB4_RS12495	COG0577	efflux transmembrane transporter activity
CB4_RS12515	COG1686	Belongs to the peptidase S11 family
CB4_RS12520	COG0194	GDP metabolic process
CB4_RS12530	COG3424	synthase
CB4_RS12535	COG1755	Isoprenylcysteine carboxyl methyltransferase
CB4_RS12540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_RS12550	COG0303	'Molybdopterin
CB4_RS12555	COG1763	Mo-molybdopterin cofactor biosynthetic process
CB4_RS12560	COG0314	molybdopterin synthase activity
CB4_RS12570	COG2203	Gaf domain
CB4_RS12570	COG5001	Diguanylate cyclase
CB4_RS12570	COG3706	GGDEF domain
CB4_RS12570	COG4251	negative regulation of phosphorylation
CB4_RS12580	COG1132	(ABC) transporter
CB4_RS12590	COG1090	epimerase
CB4_RS12595	COG1595	DNA-templated transcription, initiation
CB4_RS12600	COG2814	Major facilitator Superfamily
CB4_RS12605	COG0640	Transcriptional regulator
CB4_RS12615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CB4_RS12630	COG0783	Belongs to the Dps family
CB4_RS12640	COG0697	spore germination
CB4_RS12655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CB4_RS12660	COG1802	Transcriptional regulator
CB4_RS12665	COG0697	spore germination
CB4_RS12680	COG2132	Multicopper oxidase
CB4_RS12685	COG0672	)-iron permease
CB4_RS12695	COG5002	protein histidine kinase activity
CB4_RS12705	COG0488	(ABC) transporter
CB4_RS12720	COG1024	Enoyl-CoA hydratase
CB4_RS12740	COG0583	DNA-binding transcription factor activity
CB4_RS12750	COG2364	Membrane
CB4_RS12760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CB4_RS12765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CB4_RS12770	COG0656	L-ascorbic acid biosynthetic process
CB4_RS12780	COG0537	adenosine 5'-monophosphoramidase activity
CB4_RS12785	COG1061	Type III restriction enzyme res subunit
CB4_RS12805	COG0659	secondary active sulfate transmembrane transporter activity
CB4_RS12815	COG0789	Transcriptional regulator
CB4_RS12830	COG0697	spore germination
CB4_RS12835	COG0640	Transcriptional regulator
CB4_RS12840	COG2814	Major facilitator Superfamily
CB4_RS12860	COG1760	l-serine dehydratase
CB4_RS12870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CB4_RS12885	COG0840	transmembrane signaling receptor activity
CB4_RS12890	COG0726	polysaccharide deacetylase
CB4_RS12905	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CB4_RS12920	COG1116	anion transmembrane transporter activity
CB4_RS12970	COG1396	sequence-specific DNA binding
CB4_RS12995	COG1846	Transcriptional regulator
CB4_RS13000	COG1566	PFAM secretion protein HlyD family protein
CB4_RS13005	COG1566	PFAM secretion protein HlyD family protein
CB4_RS13010	COG2814	Major facilitator Superfamily
CB4_RS13025	COG0446	pyridine nucleotide-disulphide oxidoreductase
CB4_RS13030	COG1252	NADH dehydrogenase
CB4_RS13035	COG4974	Belongs to the 'phage' integrase family
CB4_RS13060	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CB4_RS13075	COG5609	conserved protein (DUF2294)
CB4_RS13080	COG3223	Belongs to the PsiE family
CB4_RS13085	COG2427	Protein of unknown function (DUF1641)
CB4_RS13090	COG3383	formate dehydrogenase (NAD+) activity
CB4_RS13095	COG1968	undecaprenyl-diphosphatase activity
CB4_RS13100	COG4608	Belongs to the ABC transporter superfamily
CB4_RS13110	COG0444	Belongs to the ABC transporter superfamily
CB4_RS13115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CB4_RS13120	COG0601	transmembrane transport
CB4_RS13125	COG0747	negative chemotaxis
CB4_RS13130	COG0672	)-iron permease
CB4_RS13160	COG0488	(ABC) transporter
CB4_RS13180	COG1012	belongs to the aldehyde dehydrogenase family
CB4_RS13185	COG0069	glutamate synthase activity
CB4_RS13190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CB4_RS13240	COG0840	transmembrane signaling receptor activity
CB4_RS13255	COG1132	(ABC) transporter
CB4_RS13265	COG1846	Transcriptional regulator
CB4_RS13280	COG5002	protein histidine kinase activity
CB4_RS13300	COG1657	PFAM Prenyltransferase squalene oxidase
CB4_RS13360	COG4974	Belongs to the 'phage' integrase family
CB4_RS13405	COG0431	NADPH-dependent FMN reductase
CB4_RS13460	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CB4_RS13465	COG1215	transferase activity, transferring glycosyl groups
CB4_RS13475	COG2124	cytochrome p450
CB4_RS13485	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
CB4_RS13495	COG1011	Hydrolase
CB4_RS13500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CB4_RS13505	COG5002	protein histidine kinase activity
CB4_RS13510	COG0745	RESPONSE REGULATOR receiver
CB4_RS13515	COG0745	RESPONSE REGULATOR receiver
CB4_RS13520	COG5002	protein histidine kinase activity
CB4_RS13530	COG1131	(ABC) transporter
CB4_RS13545	COG0791	NLP P60 protein
CB4_RS13545	COG1388	LysM domain
CB4_RS13560	COG2076	Multidrug Resistance protein
CB4_RS13565	COG1309	transcriptional regulator
CB4_RS13575	COG0586	Pfam SNARE associated Golgi protein
CB4_RS13580	COG0840	transmembrane signaling receptor activity
CB4_RS13595	COG2205	protein histidine kinase activity
CB4_RS13600	COG1587	Uroporphyrinogen-III synthase
CB4_RS13615	COG1694	Mazg nucleotide pyrophosphohydrolase
CB4_RS13630	COG1115	amino acid carrier protein
CB4_RS13635	COG0475	glutathione-regulated potassium exporter activity
CB4_RS13650	COG0640	Transcriptional regulator
CB4_RS13700	COG3091	SprT-like family
CB4_RS13715	COG1176	ABC-type spermidine putrescine transport system, permease component I
CB4_RS13725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CB4_RS13730	COG0542	response to heat
CB4_RS13735	COG2814	Major facilitator Superfamily
CB4_RS13750	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_RS13755	COG5002	protein histidine kinase activity
CB4_RS13775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CB4_RS13790	COG1215	transferase activity, transferring glycosyl groups
CB4_RS13805	COG1547	Domain of unknown function (DUF309)
CB4_RS13815	COG1388	LysM domain
CB4_RS13815	COG3584	3D domain protein
CB4_RS13820	COG0419	ATPase involved in DNA repair
CB4_RS13825	COG0420	3'-5' exonuclease activity
CB4_RS13830	COG1074	ATP-dependent DNA helicase activity
CB4_RS13835	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CB4_RS13860	COG3279	Response regulator of the LytR AlgR family
CB4_RS13865	COG2972	Histidine kinase
CB4_RS13865	COG0745	RESPONSE REGULATOR receiver
CB4_RS13875	COG0488	(ABC) transporter
CB4_RS13885	COG0704	Plays a role in the regulation of phosphate uptake
CB4_RS13890	COG5018	Exonuclease
CB4_RS13895	COG2259	Doxx family
CB4_RS13900	COG0243	molybdopterin cofactor binding
CB4_RS13915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CB4_RS13940	COG0582	viral genome integration into host DNA
CB4_RS13945	COG0574	Belongs to the PEP-utilizing enzyme family
CB4_RS13945	COG3848	Pyruvate phosphate dikinase
CB4_RS13950	COG0596	Alpha beta hydrolase
CB4_RS13950	COG0508	dehydrogenase complex catalyzes the overall conversion of
CB4_RS13965	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_RS13975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CB4_RS13985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_RS13990	COG0791	NLP P60 protein
CB4_RS13990	COG1388	LysM domain
CB4_RS13990	COG3103	Sh3 type 3 domain protein
CB4_RS13995	COG0826	peptidase U32
CB4_RS14000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CB4_RS14005	COG4224	UPF0291 protein
CB4_RS14010	COG1388	LysM domain
CB4_RS14015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CB4_RS14020	COG2839	Protein conserved in bacteria
CB4_RS14035	COG2860	membrane
CB4_RS14040	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CB4_RS14050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CB4_RS14055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CB4_RS14060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CB4_RS14065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CB4_RS14085	COG0174	glutamine synthetase
CB4_RS14090	COG0789	Transcriptional regulator
CB4_RS14095	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CB4_RS14100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CB4_RS14125	COG0784	Response regulator, receiver
CB4_RS14125	COG0835	chemotaxis
CB4_RS14130	COG0464	growth
CB4_RS14135	COG2340	Cysteine-rich secretory protein family
CB4_RS14190	COG0436	Aminotransferase
CB4_RS14195	COG2011	ABC-type metal ion transport system permease component
CB4_RS14205	COG0726	polysaccharide deacetylase
CB4_RS14210	COG1923	regulation of RNA biosynthetic process
CB4_RS14215	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CB4_RS14220	COG2136	Putative SAM-dependent methyltransferase
CB4_RS14220	COG2521	methyltransferase
CB4_RS14240	COG1506	peptidase
CB4_RS14240	COG0823	Involved in the tonB-independent uptake of proteins
CB4_RS14240	COG4946	Tricorn protease homolog
CB4_RS14250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CB4_RS14270	COG0840	transmembrane signaling receptor activity
CB4_RS14275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_RS14285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CB4_RS14305	COG1742	UPF0060 membrane protein
CB4_RS14310	COG2002	toxin-antitoxin pair type II binding
CB4_RS14325	COG1309	transcriptional regulator
CB4_RS14335	COG1971	Probably functions as a manganese efflux pump
CB4_RS14355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CB4_RS14365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CB4_RS14385	COG2378	regulation of single-species biofilm formation
CB4_RS14390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CB4_RS14395	COG0765	amino acid transport
CB4_RS14400	COG1126	abc transporter atp-binding protein
CB4_RS14415	COG5278	phosphoserine phosphatase activity
CB4_RS14415	COG0840	transmembrane signaling receptor activity
CB4_RS14425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CB4_RS14430	COG0785	Cytochrome C biogenesis protein
CB4_RS14435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB4_RS14440	COG0577	efflux transmembrane transporter activity
CB4_RS14445	COG1136	(ABC) transporter
CB4_RS14450	COG5002	protein histidine kinase activity
CB4_RS14460	COG0745	RESPONSE REGULATOR receiver
CB4_RS14520	COG1714	RDD family
CB4_RS14550	COG2318	DinB family
CB4_RS14565	COG0179	Fumarylacetoacetate (FAA) hydrolase
CB4_RS14580	COG1846	Transcriptional regulator
CB4_RS14590	COG0583	DNA-binding transcription factor activity
CB4_RS14600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CB4_RS14625	COG0840	transmembrane signaling receptor activity
CB4_RS14665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CB4_RS14670	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CB4_RS14685	COG1012	belongs to the aldehyde dehydrogenase family
CB4_RS14710	COG0840	transmembrane signaling receptor activity
CB4_RS14710	COG3290	protein histidine kinase activity
CB4_RS14720	COG4550	Control of competence regulator ComK, YlbF/YmcA
CB4_RS14730	COG2205	protein histidine kinase activity
CB4_RS14730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CB4_RS14740	COG2201	protein-glutamate methylesterase activity
CB4_RS14750	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CB4_RS14755	COG1234	tRNA 3'-trailer cleavage
CB4_RS14760	COG1013	pyruvate-flavodoxin oxidoreductase activity
CB4_RS14765	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CB4_RS14765	COG0674	pyruvate-flavodoxin oxidoreductase activity
CB4_RS14770	COG2359	stage V sporulation protein S
CB4_RS14780	COG2137	regulation of response to DNA damage stimulus
CB4_RS14785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CB4_RS14795	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CB4_RS14800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CB4_RS14805	COG0513	Belongs to the DEAD box helicase family
CB4_RS14810	COG1058	Belongs to the CinA family
CB4_RS14810	COG1546	Belongs to the CinA family
CB4_RS14815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CB4_RS14820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CB4_RS14830	COG1426	Protein conserved in bacteria
CB4_RS14845	COG0300	oxidoreductase activity
CB4_RS14850	COG0612	Peptidase, M16
CB4_RS14855	COG0612	Peptidase, M16
CB4_RS14870	COG1566	PFAM secretion protein HlyD family protein
CB4_RS14875	COG2814	Major facilitator Superfamily
CB4_RS14890	COG0574	Belongs to the PEP-utilizing enzyme family
CB4_RS14890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CB4_RS14895	COG1994	Peptidase M50
CB4_RS14910	COG3935	DnaD domain protein
CB4_RS14920	COG0436	Aminotransferase
CB4_RS14925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CB4_RS14940	COG0402	S-adenosylhomocysteine deaminase activity
CB4_RS14945	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CB4_RS14950	COG1199	ATP-dependent helicase activity
CB4_RS14950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CB4_RS14965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CB4_RS14970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CB4_RS14975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CB4_RS14975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CB4_RS14980	COG0617	tRNA 3'-terminal CCA addition
CB4_RS14985	COG0438	transferase activity, transferring glycosyl groups
CB4_RS14990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CB4_RS14995	COG1803	Methylglyoxal synthase
CB4_RS15000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CB4_RS15005	COG1694	Mazg nucleotide pyrophosphohydrolase
CB4_RS15010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CB4_RS15065	COG1595	DNA-templated transcription, initiation
CB4_RS15085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CB4_RS15090	COG0287	Prephenate dehydrogenase
CB4_RS15095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CB4_RS15100	COG0159	tryptophan synthase activity
CB4_RS15110	COG0135	phosphoribosylanthranilate isomerase activity
CB4_RS15115	COG0134	indole-3-glycerol-phosphate synthase activity
CB4_RS15120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CB4_RS15135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CB4_RS15140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CB4_RS15150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CB4_RS15155	COG0105	UTP biosynthetic process
CB4_RS15160	COG0142	geranyltranstransferase activity
CB4_RS15170	COG0163	prenyltransferase activity
CB4_RS15175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CB4_RS15180	COG2226	methyltransferase
CB4_RS15185	COG0142	geranyltranstransferase activity
CB4_RS15200	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CB4_RS15230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CB4_RS15235	COG1160	GTP binding
CB4_RS15255	COG0539	negative regulation of cytoplasmic translation
CB4_RS15265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CB4_RS15275	COG2959	enzyme of heme biosynthesis
CB4_RS15280	COG2339	peptidase activity
CB4_RS15295	COG0492	ferredoxin-NADP+ reductase activity
CB4_RS15300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CB4_RS15305	COG4862	establishment of competence for transformation
CB4_RS15310	COG2357	RelA SpoT domain protein
CB4_RS15315	COG0674	pyruvate-flavodoxin oxidoreductase activity
CB4_RS15325	COG0492	ferredoxin-NADP+ reductase activity
CB4_RS15345	COG0514	ATP-dependent DNA helicase (RecQ)
CB4_RS15350	COG4955	Helix-turn-helix domain
CB4_RS15355	COG1141	Ferredoxin
CB4_RS15385	COG1876	peptidase activity
CB4_RS15515	COG4626	Terminase
CB4_RS15515	COG1802	Transcriptional regulator
CB4_RS15535	COG2359	stage V sporulation protein S
CB4_RS15685	COG0582	viral genome integration into host DNA
CB4_RS15715	COG1116	anion transmembrane transporter activity
CB4_RS15735	COG2205	protein histidine kinase activity
CB4_RS15745	COG1113	amino acid transport
CB4_RS15795	COG3655	Transcriptional regulator
CB4_RS15865	COG0598	Magnesium transport protein CorA
CB4_RS15890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CB4_RS15905	COG0300	oxidoreductase activity
CB4_RS15910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CB4_RS15915	COG2050	protein possibly involved in aromatic compounds catabolism
CB4_RS15920	COG5002	protein histidine kinase activity
CB4_RS15925	COG0745	RESPONSE REGULATOR receiver
CB4_RS15930	COG0824	Thioesterase
CB4_RS15940	COG5002	protein histidine kinase activity
CB4_RS15945	COG0745	RESPONSE REGULATOR receiver
CB4_RS15955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CB4_RS15960	COG1333	cytochrome c biogenesis protein
CB4_RS15965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CB4_RS15975	COG1187	pseudouridine synthase activity
CB4_RS15980	COG0700	Nucleoside recognition
CB4_RS15985	COG2715	membrane protein required for spore maturation
CB4_RS15990	COG1686	Belongs to the peptidase S11 family
CB4_RS15995	COG1914	H( )-stimulated, divalent metal cation uptake system
CB4_RS16010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CB4_RS16015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CB4_RS16020	COG1994	Peptidase M50
CB4_RS16025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CB4_RS16030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CB4_RS16030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CB4_RS16035	COG0307	riboflavin synthase, alpha
CB4_RS16040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CB4_RS16040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CB4_RS16045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CB4_RS16055	COG5278	phosphoserine phosphatase activity
CB4_RS16055	COG0840	transmembrane signaling receptor activity
CB4_RS16065	COG1201	RNA secondary structure unwinding
CB4_RS16090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CB4_RS16095	COG3250	beta-galactosidase activity
CB4_RS16100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CB4_RS16105	COG0579	oxidoreductase
CB4_RS16125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CB4_RS16140	COG1176	ABC-type spermidine putrescine transport system, permease component I
CB4_RS16150	COG3842	ATPase activity
CB4_RS16155	COG0537	adenosine 5'-monophosphoramidase activity
CB4_RS16160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CB4_RS16165	COG0019	diaminopimelate decarboxylase activity
CB4_RS16180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_RS16205	COG2172	sigma factor antagonist activity
CB4_RS16215	COG1686	Belongs to the peptidase S11 family
CB4_RS16240	COG0384	phenazine biosynthesis protein PhzF
CB4_RS16245	COG4608	Belongs to the ABC transporter superfamily
CB4_RS16250	COG0444	Belongs to the ABC transporter superfamily
CB4_RS16255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CB4_RS16260	COG0601	transmembrane transport
CB4_RS16265	COG4166	transmembrane transport
CB4_RS16270	COG0840	transmembrane signaling receptor activity
CB4_RS16290	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CB4_RS16295	COG4974	Belongs to the 'phage' integrase family
CB4_RS16305	COG0768	penicillin binding
CB4_RS16315	COG0735	belongs to the Fur family
CB4_RS16320	COG1300	Membrane
CB4_RS16325	COG0494	nUDIX hydrolase
CB4_RS16345	COG2195	Cleaves the N-terminal amino acid of tripeptides
CB4_RS16355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CB4_RS16360	COG0346	lactoylglutathione lyase activity
CB4_RS16365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CB4_RS16365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CB4_RS16370	COG0508	dehydrogenase complex catalyzes the overall conversion of
CB4_RS16375	COG0022	dehydrogenase e1 component
CB4_RS16380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CB4_RS16385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CB4_RS16390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CB4_RS16395	COG3829	transcription factor binding
CB4_RS16395	COG3290	protein histidine kinase activity
CB4_RS16405	COG1215	transferase activity, transferring glycosyl groups
CB4_RS16420	COG0534	Mate efflux family protein
CB4_RS16440	COG0840	transmembrane signaling receptor activity
CB4_RS16445	COG4585	Histidine kinase
CB4_RS16450	COG2197	response regulator
CB4_RS16465	COG1253	flavin adenine dinucleotide binding
CB4_RS16470	COG2738	Putative neutral zinc metallopeptidase
CB4_RS16480	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CB4_RS16495	COG1595	DNA-templated transcription, initiation
CB4_RS16505	COG0726	polysaccharide deacetylase
CB4_RS16530	COG1012	belongs to the aldehyde dehydrogenase family
CB4_RS16545	COG0010	Belongs to the arginase family
CB4_RS16550	COG4848	Belongs to the UPF0354 family
CB4_RS16575	COG0180	Tryptophanyl-tRNA synthetase
CB4_RS16610	COG1392	Phosphate transport regulator
CB4_RS16615	COG0306	phosphate transporter
CB4_RS16630	COG2346	COG2346, Truncated hemoglobins
CB4_RS16635	COG0741	lytic transglycosylase activity
CB4_RS16640	COG0318	PFAM AMP-dependent synthetase and ligase
CB4_RS16650	COG2154	pterin-4-alpha-carbinolamine dehydratase
CB4_RS16660	COG0784	Response regulator, receiver
CB4_RS16665	COG0784	Response regulator, receiver
CB4_RS16665	COG2205	protein histidine kinase activity
CB4_RS16665	COG5002	protein histidine kinase activity
CB4_RS16670	COG1744	ABC transporter substrate-binding protein PnrA-like
CB4_RS16675	COG2204	response regulator
CB4_RS16685	COG1309	transcriptional regulator
CB4_RS16735	COG1131	(ABC) transporter
CB4_RS16745	COG0791	NLP P60 protein
CB4_RS16745	COG1388	LysM domain
CB4_RS16750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CB4_RS16755	COG0205	6-phosphofructokinase activity
CB4_RS16760	COG1940	carbohydrate kinase activity
CB4_RS16775	COG0840	transmembrane signaling receptor activity
CB4_RS16795	COG2208	phosphoserine phosphatase activity
CB4_RS16800	COG0477	Major facilitator Superfamily
CB4_RS16810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CB4_RS16815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CB4_RS16820	COG2610	gluconate transmembrane transporter activity
CB4_RS16825	COG2204	response regulator
CB4_RS16845	COG2318	DinB family
CB4_RS16860	COG0454	-acetyltransferase
CB4_RS16875	COG1116	anion transmembrane transporter activity
CB4_RS16880	COG4120	Belongs to the binding-protein-dependent transport system permease family
CB4_RS16890	COG0564	pseudouridine synthase activity
CB4_RS16895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CB4_RS16915	COG4974	Belongs to the 'phage' integrase family
CB4_RS16925	COG3874	Sporulation protein YtfJ
CB4_RS16940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CB4_RS16945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CB4_RS16950	COG0531	amino acid
CB4_RS16955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_RS16965	COG0861	Integral membrane protein TerC family
CB4_RS16970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB4_RS16975	COG2258	MOSC domain
CB4_RS16985	COG0745	RESPONSE REGULATOR receiver
CB4_RS16990	COG5002	protein histidine kinase activity
CB4_RS17000	COG0788	formyltetrahydrofolate deformylase activity
CB4_RS17010	COG0561	phosphatase activity
CB4_RS17020	COG0004	ammonium transporteR
CB4_RS17035	COG2346	COG2346, Truncated hemoglobins
CB4_RS17045	COG2030	dehydratase
CB4_RS17070	COG3243	poly(R)-hydroxyalkanoic acid synthase
CB4_RS17075	COG0301	tRNA thio-modification
CB4_RS17080	COG1104	cysteine desulfurase activity
CB4_RS17095	COG1473	amidohydrolase
CB4_RS17100	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_RS17105	COG0300	oxidoreductase activity
CB4_RS17110	COG2155	Conserved Protein
CB4_RS17115	COG3069	C4-dicarboxylate transmembrane transporter activity
CB4_RS17150	COG0644	oxidoreductase
CB4_RS17155	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CB4_RS17170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CB4_RS17190	COG2081	HI0933 family
CB4_RS17200	COG3162	membrane
CB4_RS17205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CB4_RS17210	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CB4_RS17215	COG1309	transcriptional regulator
CB4_RS17230	COG2199	diguanylate cyclase activity
CB4_RS17230	COG2203	Gaf domain
CB4_RS17235	COG0406	alpha-ribazole phosphatase activity
CB4_RS17240	COG0133	tryptophan synthase activity
CB4_RS17245	COG0697	spore germination
CB4_RS17250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CB4_RS17255	COG0789	Transcriptional regulator
CB4_RS17260	COG2814	Major facilitator Superfamily
CB4_RS17265	COG0784	Response regulator, receiver
CB4_RS17265	COG3437	response regulator, receiver
CB4_RS17275	COG2197	response regulator
CB4_RS17280	COG0840	transmembrane signaling receptor activity
CB4_RS17285	COG4585	Histidine kinase
CB4_RS17290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CB4_RS17295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CB4_RS17300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_RS17305	COG0454	-acetyltransferase
CB4_RS17310	COG0517	IMP dehydrogenase activity
CB4_RS17315	COG0123	including yeast histone deacetylase and acetoin utilization protein
CB4_RS17330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CB4_RS17330	COG1605	Chorismate mutase
CB4_RS17360	COG3118	belongs to the thioredoxin family
CB4_RS17365	COG0473	3-isopropylmalate dehydrogenase activity
CB4_RS17385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CB4_RS17390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CB4_RS17400	COG0517	IMP dehydrogenase activity
CB4_RS17405	COG0772	Belongs to the SEDS family
CB4_RS17410	COG0772	Belongs to the SEDS family
CB4_RS17415	COG2239	Acts as a magnesium transporter
CB4_RS17420	COG1285	pathogenesis
CB4_RS17460	COG3546	catalase activity
CB4_RS17465	COG0778	Nitroreductase
CB4_RS17470	COG3331	DNA recombination
CB4_RS17475	COG1547	Domain of unknown function (DUF309)
CB4_RS17480	COG0492	ferredoxin-NADP+ reductase activity
CB4_RS17565	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_RS17575	COG0410	ABC transporter
CB4_RS17610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CB4_RS17620	COG0315	cyclic pyranopterin monophosphate synthase activity
CB4_RS17625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CB4_RS17630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CB4_RS17655	COG1674	ftsk spoiiie
CB4_RS17660	COG0789	Transcriptional regulator
CB4_RS17685	COG0129	dihydroxy-acid dehydratase activity
CB4_RS17690	COG1376	ErfK ybiS ycfS ynhG family protein
CB4_RS17700	COG0697	spore germination
CB4_RS17730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CB4_RS17735	COG1131	(ABC) transporter
CB4_RS17740	COG0842	Transport permease protein
CB4_RS17745	COG1309	transcriptional regulator
CB4_RS17750	COG1187	pseudouridine synthase activity
CB4_RS17760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CB4_RS17775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CB4_RS17780	COG0602	queuosine metabolic process
CB4_RS17785	COG0720	synthase
CB4_RS17790	COG0483	inositol monophosphate 1-phosphatase activity
CB4_RS17795	COG2226	methyltransferase
CB4_RS17810	COG0861	Integral membrane protein TerC family
CB4_RS17820	COG0513	Belongs to the DEAD box helicase family
CB4_RS17825	COG0352	thiamine-phosphate diphosphorylase activity
CB4_RS17835	COG2104	thiamine diphosphate biosynthetic process
CB4_RS17840	COG2022	thiamine diphosphate biosynthetic process
CB4_RS17850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CB4_RS17865	COG2814	Major facilitator Superfamily
CB4_RS17880	COG1242	4 iron, 4 sulfur cluster binding
CB4_RS17890	COG0513	Belongs to the DEAD box helicase family
CB4_RS17895	COG1217	gtp-binding protein TYPA
CB4_RS17905	COG1278	Cold shock
CB4_RS17910	COG2267	carboxylic ester hydrolase activity
CB4_RS17920	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CB4_RS17930	COG1960	acyl-CoA dehydrogenase activity
CB4_RS17935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CB4_RS17955	COG0454	-acetyltransferase
CB4_RS17990	COG0583	DNA-binding transcription factor activity
CB4_RS17995	COG0840	transmembrane signaling receptor activity
CB4_RS18000	COG0726	polysaccharide deacetylase
CB4_RS18010	COG0778	Nitroreductase
CB4_RS18015	COG0840	transmembrane signaling receptor activity
CB4_RS18025	COG1361	Conserved repeat domain
CB4_RS18035	COG1556	Lactate utilization protein
CB4_RS18040	COG1139	Iron-sulfur cluster binding protein
CB4_RS18085	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CB4_RS18090	COG1024	Enoyl-CoA hydratase
CB4_RS18110	COG1024	Enoyl-CoA hydratase
CB4_RS18120	COG2050	protein possibly involved in aromatic compounds catabolism
CB4_RS18130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_RS18140	COG1607	acyl-coa hydrolase
CB4_RS18150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CB4_RS18155	COG1879	ABC-type sugar transport system periplasmic component
CB4_RS18160	COG1172	Belongs to the binding-protein-dependent transport system permease family
CB4_RS18165	COG1129	ABC transporter
CB4_RS18170	COG1869	D-ribose catabolic process
CB4_RS18175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CB4_RS18180	COG1609	Transcriptional regulator
CB4_RS18205	COG0688	phosphatidylethanolamine metabolic process
CB4_RS18220	COG1832	CoA-binding protein
CB4_RS18230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CB4_RS18235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CB4_RS18240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CB4_RS18245	COG2200	EAL domain
CB4_RS18250	COG0840	transmembrane signaling receptor activity
CB4_RS18260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB4_RS18275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CB4_RS18290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CB4_RS18300	COG5583	Uncharacterized small protein (DUF2292)
CB4_RS18310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CB4_RS18320	COG1484	DNA-dependent DNA replication
CB4_RS18325	COG3611	Membrane attachment protein
CB4_RS18330	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CB4_RS18335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CB4_RS18340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CB4_RS18345	COG0739	heme binding
CB4_RS18345	COG1196	nuclear chromosome segregation
CB4_RS18345	COG0741	lytic transglycosylase activity
CB4_RS18350	COG0237	dephospho-CoA kinase activity
CB4_RS18355	COG1971	Probably functions as a manganese efflux pump
CB4_RS18360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CB4_RS18365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CB4_RS18365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CB4_RS18370	COG0330	HflC and HflK could
CB4_RS18375	COG5002	protein histidine kinase activity
CB4_RS18380	COG0745	RESPONSE REGULATOR receiver
CB4_RS18385	COG0039	L-malate dehydrogenase activity
CB4_RS18390	COG0538	isocitrate dehydrogenase activity
CB4_RS18395	COG0372	Belongs to the citrate synthase family
CB4_RS18400	COG0628	permease
CB4_RS18405	COG3030	protein affecting phage T7 exclusion by the F plasmid
CB4_RS18410	COG0824	Thioesterase
CB4_RS18420	COG0825	malonyl-CoA metabolic process
CB4_RS18425	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CB4_RS18430	COG2186	Transcriptional regulator
CB4_RS18435	COG0281	malic enzyme
CB4_RS18440	COG0587	DNA-directed DNA polymerase activity
CB4_RS18460	COG4948	Mandelate Racemase Muconate Lactonizing
CB4_RS18465	COG2311	Membrane
CB4_RS18475	COG1741	Belongs to the pirin family
CB4_RS18480	COG1846	Transcriptional regulator
CB4_RS18495	COG4109	DRTGG domain
CB4_RS18505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CB4_RS18510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CB4_RS18515	COG0189	ligase activity
CB4_RS18520	COG0189	ligase activity
CB4_RS18525	COG0189	ligase activity
CB4_RS18550	COG0436	Aminotransferase
CB4_RS18560	COG1683	Conserved Protein
CB4_RS18570	COG1937	Protein conserved in bacteria
CB4_RS18625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB4_RS18640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CB4_RS18650	COG5002	protein histidine kinase activity
CB4_RS18655	COG3123	guanosine phosphorylase activity
CB4_RS18665	COG0737	Belongs to the 5'-nucleotidase family
CB4_RS18670	COG0737	Belongs to the 5'-nucleotidase family
CB4_RS18675	COG0494	nUDIX hydrolase
CB4_RS18680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CB4_RS18680	COG0723	plastoquinol--plastocyanin reductase activity
CB4_RS18745	COG5002	protein histidine kinase activity
CB4_RS18750	COG0346	lactoylglutathione lyase activity
CB4_RS18760	COG3693	PFAM glycoside hydrolase, family 10
CB4_RS18765	COG2719	SpoVR family
CB4_RS18805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CB4_RS18830	COG2719	SpoVR family
CB4_RS18890	COG2718	Belongs to the UPF0229 family
CB4_RS18895	COG2766	serine protein kinase
CB4_RS18905	COG1464	Belongs to the NlpA lipoprotein family
CB4_RS18925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CB4_RS18930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CB4_RS18935	COG0328	RNA-DNA hybrid ribonuclease activity
CB4_RS18940	COG0477	Major facilitator Superfamily
CB4_RS18945	COG2233	PERMEase
CB4_RS18950	COG1573	uracil-dna glycosylase
CB4_RS18955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CB4_RS19065	COG0735	belongs to the Fur family
CB4_RS19105	COG2096	Adenosyltransferase
CB4_RS19115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CB4_RS19180	COG4555	ABC transporter
CB4_RS19185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CB4_RS19190	COG0070	glutamate synthase
CB4_RS19190	COG0067	glutamate synthase
CB4_RS19190	COG0069	glutamate synthase activity
CB4_RS19195	COG4129	membrane
CB4_RS19200	COG1850	ribulose-bisphosphate carboxylase activity
CB4_RS19205	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CB4_RS19210	COG0235	Class ii aldolase
CB4_RS19215	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CB4_RS19220	COG2132	Multicopper oxidase
CB4_RS19235	COG1725	Transcriptional regulator
CB4_RS19240	COG1131	(ABC) transporter
CB4_RS19245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CB4_RS19250	COG1132	(ABC) transporter
CB4_RS19255	COG3557	Belongs to the UPF0374 family
CB4_RS19290	COG0670	Belongs to the BI1 family
CB4_RS19310	COG1988	membrane-bound metal-dependent
CB4_RS19325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CB4_RS19330	COG0534	Mate efflux family protein
CB4_RS19340	COG0529	Catalyzes the synthesis of activated sulfate
CB4_RS19345	COG2046	Belongs to the sulfate adenylyltransferase family
CB4_RS19350	COG0175	sulfate reduction
CB4_RS19355	COG0306	phosphate transporter
CB4_RS19365	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CB4_RS19375	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CB4_RS19380	COG1012	belongs to the aldehyde dehydrogenase family
CB4_RS19385	COG3290	protein histidine kinase activity
CB4_RS19385	COG3829	transcription factor binding
CB4_RS19395	COG0840	transmembrane signaling receptor activity
CB4_RS19435	COG1183	phosphatidylcholine synthase activity
CB4_RS19440	COG1187	pseudouridine synthase activity
CB4_RS19455	COG2201	protein-glutamate methylesterase activity
CB4_RS19480	COG2199	diguanylate cyclase activity
CB4_RS19480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CB4_RS19490	COG0463	Glycosyl transferase, family 2
CB4_RS19495	COG0728	peptidoglycan biosynthetic process
CB4_RS19505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CB4_RS19530	COG0438	transferase activity, transferring glycosyl groups
CB4_RS19550	COG1396	sequence-specific DNA binding
CB4_RS19680	COG0840	transmembrane signaling receptor activity
CB4_RS19710	COG2267	carboxylic ester hydrolase activity
CB4_RS19720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CB4_RS19725	COG4840	Belongs to the UPF0435 family
CB4_RS19730	COG0598	Magnesium transport protein CorA
CB4_RS19755	COG0840	transmembrane signaling receptor activity
CB4_RS19760	COG2011	ABC-type metal ion transport system permease component
CB4_RS19765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CB4_RS19785	COG4715	Zinc finger, swim domain protein
CB4_RS19790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CB4_RS19795	COG1132	(ABC) transporter
CB4_RS19805	COG1876	peptidase activity
CB4_RS19810	COG0501	Belongs to the peptidase M48B family
CB4_RS19855	COG1607	acyl-coa hydrolase
CB4_RS19865	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CB4_RS19870	COG0709	Synthesizes selenophosphate from selenide and ATP
CB4_RS19875	COG1388	LysM domain
CB4_RS19875	COG0791	NLP P60 protein
CB4_RS19885	COG0667	Aldo Keto reductase
CB4_RS19890	COG0778	Nitroreductase
CB4_RS19895	COG1733	regulation of RNA biosynthetic process
CB4_RS19900	COG1522	sequence-specific DNA binding
CB4_RS19905	COG2814	Major facilitator Superfamily
CB4_RS19910	COG0531	amino acid
CB4_RS19940	COG1361	Conserved repeat domain
CB4_RS19940	COG3266	domain, Protein
CB4_RS19940	COG2911	Protein conserved in bacteria
CB4_RS19945	COG3279	Response regulator of the LytR AlgR family
CB4_RS19950	COG2972	Histidine kinase
CB4_RS19950	COG0745	RESPONSE REGULATOR receiver
CB4_RS20100	COG1028	Short-chain dehydrogenase reductase Sdr
CB4_RS20105	COG1794	racemase activity, acting on amino acids and derivatives
CB4_RS20120	COG4282	regulation of fungal-type cell wall biogenesis
CB4_RS20135	COG3266	domain, Protein
CB4_RS20135	COG2911	Protein conserved in bacteria
CB4_RS20135	COG1361	Conserved repeat domain
CB4_RS20150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CB4_RS20155	COG1597	lipid kinase activity
CB4_RS20160	COG0247	lactate metabolic process
CB4_RS20165	COG0277	FAD linked oxidase domain protein
CB4_RS20170	COG2186	Transcriptional regulator
CB4_RS20180	COG0194	GDP metabolic process
CB4_RS20195	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CB4_RS20200	COG0154	amidase activity
CB4_RS20215	COG1396	sequence-specific DNA binding
CB4_RS20220	COG3384	dioxygenase
CB4_RS20225	COG2259	Doxx family
CB4_RS20250	COG0840	transmembrane signaling receptor activity
CB4_RS20255	COG2208	phosphoserine phosphatase activity
CB4_RS20270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CB4_RS20275	COG0210	DNA helicase
CB4_RS20280	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CB4_RS20285	COG4496	protein, YerC YecD
CB4_RS20295	COG0386	Belongs to the glutathione peroxidase family
CB4_RS20305	COG2814	Major facilitator Superfamily
CB4_RS20310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CB4_RS20345	COG0151	Belongs to the GarS family
CB4_RS20355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CB4_RS20360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CB4_RS20365	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CB4_RS20370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CB4_RS20375	COG0047	phosphoribosylformylglycinamidine synthase activity
CB4_RS20380	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CB4_RS20385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CB4_RS20390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CB4_RS20395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CB4_RS20400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CB4_RS20415	COG3437	response regulator, receiver
CB4_RS20420	COG5002	protein histidine kinase activity
CB4_RS20420	COG2205	protein histidine kinase activity
CB4_RS20420	COG0784	Response regulator, receiver
CB4_RS20425	COG2252	PERMEase
CB4_RS20430	COG0519	Catalyzes the synthesis of GMP from XMP
CB4_RS20430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CB4_RS20440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CB4_RS20445	COG1823	symporter activity
CB4_RS20450	COG0521	Mo-molybdopterin cofactor biosynthetic process
CB4_RS20455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CB4_RS20475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CB4_RS20480	COG0840	transmembrane signaling receptor activity
CB4_RS20485	COG0840	transmembrane signaling receptor activity
CB4_RS20485	COG3290	protein histidine kinase activity
CB4_RS20490	COG0456	acetyltransferase
CB4_RS20495	COG1214	PFAM Peptidase M22, glycoprotease
CB4_RS20500	COG0802	atpase or kinase
CB4_RS20505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CB4_RS20510	COG3091	SprT-like family
CB4_RS20525	COG2183	response to ionizing radiation
CB4_RS20530	COG2337	Toxic component of a toxin-antitoxin (TA) module
CB4_RS20535	COG0864	Transcriptional regulator
CB4_RS20540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CB4_RS20640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CB4_RS20645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CB4_RS20645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CB4_RS20650	COG0736	holo-[acyl-carrier-protein] synthase activity
CB4_RS20655	COG0860	N-Acetylmuramoyl-L-alanine amidase
CB4_RS20670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CB4_RS20675	COG1316	TRANSCRIPTIONal
CB4_RS20690	COG0463	Glycosyl transferase, family 2
CB4_RS20700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CB4_RS20705	COG0785	Cytochrome C biogenesis protein
CB4_RS20710	COG2208	phosphoserine phosphatase activity
CB4_RS20715	COG1366	Belongs to the anti-sigma-factor antagonist family
CB4_RS20725	COG0840	transmembrane signaling receptor activity
CB4_RS20730	COG0643	Histidine kinase
CB4_RS20730	COG2198	Histidine kinase
CB4_RS20735	COG0835	chemotaxis
CB4_RS20740	COG1959	2 iron, 2 sulfur cluster binding
CB4_RS20745	COG2910	NAD(P)H-binding
CB4_RS20750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CB4_RS20755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity