locus-tag	class	description
ACH33_RS00025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACH33_RS00030	COG3852	Histidine kinase
ACH33_RS00050	COG1659	Linocin_M18 bacteriocin protein
ACH33_RS00065	COG1309	transcriptional regulator
ACH33_RS00070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACH33_RS00080	COG0590	tRNA wobble adenosine to inosine editing
ACH33_RS00085	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACH33_RS00090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACH33_RS00095	COG0596	Alpha beta hydrolase
ACH33_RS00105	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACH33_RS00110	COG1024	Enoyl-CoA hydratase
ACH33_RS00115	COG3290	protein histidine kinase activity
ACH33_RS00115	COG3829	transcription factor binding
ACH33_RS00120	COG2112	serine threonine protein kinase
ACH33_RS00130	COG1842	Phage shock protein A
ACH33_RS00135	COG0776	regulation of translation
ACH33_RS00145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACH33_RS00145	COG1587	Uroporphyrinogen-III synthase
ACH33_RS00175	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ACH33_RS00200	COG1122	ATPase activity
ACH33_RS00215	COG0310	cobalt ion transport
ACH33_RS00250	COG0582	viral genome integration into host DNA
ACH33_RS00275	COG2315	Protein conserved in bacteria
ACH33_RS00285	COG1476	TRANSCRIPTIONal
ACH33_RS00300	COG0579	oxidoreductase
ACH33_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS00320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACH33_RS00330	COG0516	GMP reductase activity
ACH33_RS00330	COG0517	IMP dehydrogenase activity
ACH33_RS00355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACH33_RS00360	COG0187	DNA topoisomerase II activity
ACH33_RS00370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACH33_RS00375	COG2501	S4 domain
ACH33_RS00380	COG0592	DNA-directed DNA polymerase activity
ACH33_RS00385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACH33_RS00390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACH33_RS00400	COG0706	membrane insertase activity
ACH33_RS00405	COG1847	R3H domain protein
ACH33_RS00410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACH33_RS00415	COG0445	tRNA wobble uridine modification
ACH33_RS00420	COG0357	Ribosomal RNA small subunit methyltransferase G
ACH33_RS00430	COG1475	DNA binding
ACH33_RS00435	COG1192	Involved in chromosome partitioning
ACH33_RS00440	COG1475	DNA binding
ACH33_RS00445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACH33_RS00460	COG0668	transmembrane transport
ACH33_RS00465	COG4481	Protein conserved in bacteria
ACH33_RS00470	COG0012	GTP binding
ACH33_RS00475	COG0360	Binds together with S18 to 16S ribosomal RNA
ACH33_RS00480	COG0629	single-stranded DNA binding
ACH33_RS00485	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACH33_RS00490	COG4241	membrane
ACH33_RS00495	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ACH33_RS00505	COG0305	Participates in initiation and elongation during chromosome replication
ACH33_RS00510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACH33_RS00515	COG0739	heme binding
ACH33_RS00520	COG0745	RESPONSE REGULATOR receiver
ACH33_RS00525	COG5002	protein histidine kinase activity
ACH33_RS00530	COG4863	YycH protein
ACH33_RS00535	COG4853	Protein conserved in bacteria
ACH33_RS00540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACH33_RS00545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACH33_RS00555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACH33_RS00560	COG1120	ATPase activity
ACH33_RS00565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS00570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS00575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ACH33_RS00580	COG3973	AAA domain
ACH33_RS00600	COG0697	spore germination
ACH33_RS00615	COG0840	transmembrane signaling receptor activity
ACH33_RS00620	COG2814	Major facilitator Superfamily
ACH33_RS00625	COG0583	DNA-binding transcription factor activity
ACH33_RS00630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACH33_RS00635	COG0583	DNA-binding transcription factor activity
ACH33_RS00650	COG2322	membrane
ACH33_RS00665	COG1845	cytochrome c oxidase, subunit III
ACH33_RS00670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ACH33_RS00675	COG0351	phosphomethylpyrimidine kinase
ACH33_RS00690	COG1801	Protein of unknown function DUF72
ACH33_RS00695	COG0432	Pfam Uncharacterised protein family UPF0047
ACH33_RS00700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACH33_RS00700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACH33_RS00705	COG1115	amino acid carrier protein
ACH33_RS00710	COG4187	Peptidase family M20/M25/M40
ACH33_RS00720	COG0546	phosphoglycolate phosphatase activity
ACH33_RS00725	COG3842	ATPase activity
ACH33_RS00730	COG1175	transmembrane transport
ACH33_RS00735	COG0395	ABC-type sugar transport system, permease component
ACH33_RS00740	COG1653	transport
ACH33_RS00745	COG0584	glycerophosphoryl diester phosphodiesterase
ACH33_RS00750	COG1846	Transcriptional regulator
ACH33_RS00755	COG1566	PFAM secretion protein HlyD family protein
ACH33_RS00760	COG2814	Major facilitator Superfamily
ACH33_RS00775	COG2234	aminopeptidase activity
ACH33_RS00785	COG2986	histidine ammonia-lyase
ACH33_RS00795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACH33_RS00800	COG0765	amino acid transport
ACH33_RS00805	COG0765	amino acid transport
ACH33_RS00810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACH33_RS00815	COG1115	amino acid carrier protein
ACH33_RS00910	COG3853	Toxic anion resistance protein (TelA)
ACH33_RS00915	COG1234	tRNA 3'-trailer cleavage
ACH33_RS00935	COG0861	Integral membrane protein TerC family
ACH33_RS00990	COG4841	protein insertion into membrane
ACH33_RS01000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACH33_RS01005	COG1131	(ABC) transporter
ACH33_RS01025	COG1414	Transcriptional regulator
ACH33_RS01030	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACH33_RS01035	COG1984	allophanate hydrolase subunit 2
ACH33_RS01040	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACH33_RS01065	COG2363	Small membrane protein
ACH33_RS01075	COG1295	ribonuclease BN
ACH33_RS01085	COG0697	spore germination
ACH33_RS01095	COG1131	(ABC) transporter
ACH33_RS01100	COG4473	ABC transporter
ACH33_RS01105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACH33_RS01115	COG0367	asparagine synthase
ACH33_RS01125	COG4844	belongs to the
ACH33_RS01135	COG0475	glutathione-regulated potassium exporter activity
ACH33_RS01135	COG0569	domain protein
ACH33_RS01140	COG4326	sporulation control protein
ACH33_RS01145	COG0564	pseudouridine synthase activity
ACH33_RS01150	COG1078	dGTPase activity
ACH33_RS01160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACH33_RS01170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACH33_RS01175	COG0010	Belongs to the arginase family
ACH33_RS01185	COG0018	arginyl-trna synthetase
ACH33_RS01265	COG2181	nitrate reductase activity
ACH33_RS01265	COG0247	lactate metabolic process
ACH33_RS01270	COG0183	Belongs to the thiolase family
ACH33_RS01280	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACH33_RS01285	COG1960	acyl-CoA dehydrogenase activity
ACH33_RS01290	COG1960	acyl-CoA dehydrogenase activity
ACH33_RS01295	COG1703	isobutyryl-CoA mutase activity
ACH33_RS01305	COG1703	isobutyryl-CoA mutase activity
ACH33_RS01305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACH33_RS01305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACH33_RS01310	COG3343	RNA polymerase activity
ACH33_RS01315	COG0504	CTP synthase activity
ACH33_RS01320	COG2204	response regulator
ACH33_RS01325	COG0191	fructose-bisphosphate aldolase activity
ACH33_RS01330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACH33_RS01335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACH33_RS01340	COG1494	fructose-1,6-bisphosphatase
ACH33_RS01345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACH33_RS01355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACH33_RS01365	COG0254	rRNA binding
ACH33_RS01370	COG1435	thymidine kinase activity
ACH33_RS01380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACH33_RS01385	COG2890	protein-(glutamine-N5) methyltransferase activity
ACH33_RS01395	COG0009	L-threonylcarbamoyladenylate synthase
ACH33_RS01420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACH33_RS01425	COG0840	transmembrane signaling receptor activity
ACH33_RS01430	COG0698	ribose 5-phosphate isomerase
ACH33_RS01435	COG4475	Protein of unknown function (DUF436)
ACH33_RS01440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACH33_RS01445	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACH33_RS01450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACH33_RS01485	COG0356	it plays a direct role in the translocation of protons across the membrane
ACH33_RS01495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACH33_RS01500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACH33_RS01505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACH33_RS01510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACH33_RS01515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACH33_RS01520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACH33_RS01525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACH33_RS01530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACH33_RS01540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACH33_RS01545	COG0649	NAD binding
ACH33_RS01550	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACH33_RS01560	COG0839	Belongs to the complex I subunit 6 family
ACH33_RS01565	COG0713	ATP synthesis coupled electron transport
ACH33_RS01570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACH33_RS01575	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACH33_RS01580	COG1007	ATP synthesis coupled electron transport
ACH33_RS01585	COG4836	Membrane
ACH33_RS01595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACH33_RS01600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACH33_RS01605	COG2385	sporulation resulting in formation of a cellular spore
ACH33_RS01610	COG0739	heme binding
ACH33_RS01615	COG1609	Transcriptional regulator
ACH33_RS01625	COG4786	Flagellar basal body rod
ACH33_RS01640	COG1522	sequence-specific DNA binding
ACH33_RS01645	COG0436	Aminotransferase
ACH33_RS01650	COG3944	biosynthesis protein
ACH33_RS01655	COG0489	protein tyrosine kinase activity
ACH33_RS01660	COG4464	protein tyrosine phosphatase activity
ACH33_RS01665	COG0673	inositol 2-dehydrogenase activity
ACH33_RS01690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACH33_RS01695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACH33_RS01705	COG1136	(ABC) transporter
ACH33_RS01720	COG3944	biosynthesis protein
ACH33_RS01760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACH33_RS01800	COG4106	trans-aconitate 2-methyltransferase activity
ACH33_RS01835	COG0438	transferase activity, transferring glycosyl groups
ACH33_RS01840	COG0438	transferase activity, transferring glycosyl groups
ACH33_RS01920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACH33_RS01950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ACH33_RS01955	COG1040	competence protein
ACH33_RS01970	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACH33_RS01975	COG2747	anti-sigma28 factor FlgM
ACH33_RS01985	COG4786	Flagellar basal body rod
ACH33_RS01985	COG1256	bacterial-type flagellum assembly
ACH33_RS01990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACH33_RS02000	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ACH33_RS02005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACH33_RS02035	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ACH33_RS02040	COG1516	flagellar protein fliS
ACH33_RS02055	COG2257	FlhB HrpN YscU SpaS Family
ACH33_RS02065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACH33_RS02070	COG0765	amino acid transport
ACH33_RS02075	COG1278	Cold shock
ACH33_RS02085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACH33_RS02095	COG0653	protein targeting
ACH33_RS02100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACH33_RS02105	COG3959	Transketolase, thiamine diphosphate binding domain
ACH33_RS02110	COG3958	Transketolase
ACH33_RS02120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACH33_RS02125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACH33_RS02135	COG0505	Belongs to the CarA family
ACH33_RS02140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACH33_RS02145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACH33_RS02160	COG1067	ATP-dependent peptidase activity
ACH33_RS02165	COG0137	argininosuccinate synthase activity
ACH33_RS02170	COG0165	Argininosuccinate lyase
ACH33_RS02175	COG2884	Cell division ATP-binding protein ftsE
ACH33_RS02180	COG2177	Part of the ABC transporter FtsEX involved in
ACH33_RS02185	COG4942	peptidase
ACH33_RS02190	COG0793	Belongs to the peptidase S41A family
ACH33_RS02190	COG3409	Peptidoglycan-binding domain 1 protein
ACH33_RS02205	COG0556	nucleotide-excision repair
ACH33_RS02210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACH33_RS02215	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ACH33_RS02230	COG0110	maltose O-acetyltransferase activity
ACH33_RS02250	COG0675	Transposase, IS605 OrfB family
ACH33_RS02255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACH33_RS02260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACH33_RS02265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACH33_RS02270	COG0131	Imidazoleglycerol-phosphate dehydratase
ACH33_RS02275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACH33_RS02280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACH33_RS02285	COG0107	imidazoleglycerol-phosphate synthase activity
ACH33_RS02290	COG0140	phosphoribosyl-ATP diphosphatase activity
ACH33_RS02290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACH33_RS02305	COG0492	ferredoxin-NADP+ reductase activity
ACH33_RS02320	COG1660	Displays ATPase and GTPase activities
ACH33_RS02325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACH33_RS02330	COG1481	regulation of sporulation
ACH33_RS02335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACH33_RS02340	COG0740	serine-type endopeptidase activity
ACH33_RS02360	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ACH33_RS02370	COG2390	Transcriptional regulator
ACH33_RS02380	COG0126	phosphoglycerate kinase activity
ACH33_RS02385	COG0149	triose-phosphate isomerase activity
ACH33_RS02390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACH33_RS02395	COG0148	phosphopyruvate hydratase activity
ACH33_RS02400	COG0735	belongs to the Fur family
ACH33_RS02405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACH33_RS02415	COG1647	Serine aminopeptidase, S33
ACH33_RS02420	COG0557	exoribonuclease II activity
ACH33_RS02425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACH33_RS02460	COG1404	Belongs to the peptidase S8 family
ACH33_RS02470	COG2755	lipolytic protein G-D-S-L family
ACH33_RS02485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACH33_RS02490	COG0745	RESPONSE REGULATOR receiver
ACH33_RS02495	COG2770	Histidine kinase
ACH33_RS02495	COG2205	protein histidine kinase activity
ACH33_RS02500	COG4264	IucA IucC family
ACH33_RS02505	COG2814	Major facilitator Superfamily
ACH33_RS02515	COG2423	ornithine cyclodeaminase activity
ACH33_RS02520	COG0019	diaminopimelate decarboxylase activity
ACH33_RS02530	COG4264	IucA IucC family
ACH33_RS02550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS02555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS02560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACH33_RS02565	COG1910	domain protein
ACH33_RS02570	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACH33_RS02575	COG4149	molybdate abc transporter
ACH33_RS02585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACH33_RS02590	COG0741	lytic transglycosylase activity
ACH33_RS02590	COG0791	NLP P60 protein
ACH33_RS02605	COG3011	Protein conserved in bacteria
ACH33_RS02610	COG0778	Nitroreductase
ACH33_RS02615	COG1473	amidohydrolase
ACH33_RS02620	COG2171	N-acyltransferase activity
ACH33_RS02635	COG0604	alcohol dehydrogenase
ACH33_RS02635	COG4221	oxidoreductase activity
ACH33_RS02635	COG3321	synthase
ACH33_RS02635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACH33_RS02650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACH33_RS02655	COG1414	Transcriptional regulator
ACH33_RS02675	COG3437	response regulator, receiver
ACH33_RS02675	COG0784	Response regulator, receiver
ACH33_RS02680	COG0646	methionine synthase
ACH33_RS02680	COG1410	methionine synthase
ACH33_RS02685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACH33_RS02685	COG0646	methionine synthase
ACH33_RS02705	COG1674	ftsk spoiiie
ACH33_RS02755	COG0180	Tryptophanyl-tRNA synthetase
ACH33_RS02765	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ACH33_RS02780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACH33_RS02790	COG0109	protoheme IX farnesyltransferase activity
ACH33_RS02800	COG1999	signal sequence binding
ACH33_RS02805	COG2508	Transcriptional regulator
ACH33_RS02805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ACH33_RS02810	COG0686	Belongs to the AlaDH PNT family
ACH33_RS02825	COG2226	methyltransferase
ACH33_RS02835	COG1119	ATPase activity
ACH33_RS02840	COG0277	FAD linked oxidase domain protein
ACH33_RS02860	COG0482	sulfurtransferase activity
ACH33_RS02870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACH33_RS02880	COG4846	Membrane protein involved in cytochrome C biogenesis
ACH33_RS02885	COG0833	amino acid
ACH33_RS02890	COG2186	Transcriptional regulator
ACH33_RS02895	COG1620	l-lactate permease
ACH33_RS02900	COG1757	Na H antiporter
ACH33_RS02905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACH33_RS02915	COG1956	GAF domain-containing protein
ACH33_RS02920	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS02925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACH33_RS02930	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACH33_RS02935	COG0477	Major facilitator Superfamily
ACH33_RS02940	COG1492	cobalamin metabolic process
ACH33_RS02950	COG0778	Nitroreductase
ACH33_RS02955	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ACH33_RS02960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACH33_RS02965	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
ACH33_RS02970	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ACH33_RS02975	COG0406	alpha-ribazole phosphatase activity
ACH33_RS03005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACH33_RS03010	COG1739	Uncharacterized protein family UPF0029
ACH33_RS03015	COG2350	Protein conserved in bacteria
ACH33_RS03020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACH33_RS03035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACH33_RS03045	COG5577	PFAM Coat F domain
ACH33_RS03060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACH33_RS03065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACH33_RS03070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACH33_RS03075	COG0697	spore germination
ACH33_RS03095	COG0477	Major facilitator Superfamily
ACH33_RS03100	COG1126	abc transporter atp-binding protein
ACH33_RS03110	COG3706	GGDEF domain
ACH33_RS03115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACH33_RS03120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS03125	COG1120	ATPase activity
ACH33_RS03130	COG1393	Belongs to the ArsC family
ACH33_RS03135	COG0436	Aminotransferase
ACH33_RS03145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACH33_RS03150	COG0509	glycine decarboxylation via glycine cleavage system
ACH33_RS03170	COG1191	sigma factor activity
ACH33_RS03175	COG2755	lipolytic protein G-D-S-L family
ACH33_RS03185	COG0396	ATPase activity
ACH33_RS03190	COG0719	Fe-S assembly protein
ACH33_RS03195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACH33_RS03200	COG0822	iron-sulfur transferase activity
ACH33_RS03205	COG0719	Fe-S assembly protein
ACH33_RS03235	COG1846	Transcriptional regulator
ACH33_RS03240	COG2814	Major facilitator Superfamily
ACH33_RS03265	COG0730	response to heat
ACH33_RS03270	COG0737	Belongs to the 5'-nucleotidase family
ACH33_RS03280	COG3377	Domain of unknown function (DUF1805)
ACH33_RS03285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACH33_RS03295	COG2814	Major facilitator Superfamily
ACH33_RS03300	COG0791	NLP P60 protein
ACH33_RS03315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACH33_RS03335	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ACH33_RS03340	COG3963	phosphatidate phosphatase activity
ACH33_RS03345	COG1376	ErfK ybiS ycfS ynhG family protein
ACH33_RS03350	COG0739	heme binding
ACH33_RS03355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACH33_RS03365	COG4470	Protein conserved in bacteria
ACH33_RS03380	COG2445	Protein of unknown function DUF86
ACH33_RS03390	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ACH33_RS03395	COG0647	UMP catabolic process
ACH33_RS03400	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACH33_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS03410	COG0494	nUDIX hydrolase
ACH33_RS03415	COG2814	Major facilitator Superfamily
ACH33_RS03420	COG0583	DNA-binding transcription factor activity
ACH33_RS03425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACH33_RS03430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACH33_RS03435	COG0626	cystathionine gamma-synthase activity
ACH33_RS03440	COG4837	Protein of unknown function (DUF1462)
ACH33_RS03455	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACH33_RS03460	COG0316	Belongs to the HesB IscA family
ACH33_RS03470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACH33_RS03490	COG1252	NADH dehydrogenase
ACH33_RS03510	COG3584	3D domain protein
ACH33_RS03515	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ACH33_RS03520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACH33_RS03525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACH33_RS03535	COG0028	Belongs to the TPP enzyme family
ACH33_RS03540	COG0440	acetolactate synthase activity
ACH33_RS03545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACH33_RS03550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACH33_RS03555	COG0473	3-isopropylmalate dehydrogenase activity
ACH33_RS03580	COG2155	Conserved Protein
ACH33_RS03590	COG1363	Peptidase, m42
ACH33_RS03600	COG0569	domain protein
ACH33_RS03605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACH33_RS03615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACH33_RS03620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACH33_RS03620	COG0072	phenylalanine-tRNA ligase activity
ACH33_RS03625	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ACH33_RS03630	COG1286	toxin biosynthetic process
ACH33_RS03635	COG0583	DNA-binding transcription factor activity
ACH33_RS03640	COG0531	amino acid
ACH33_RS03645	COG1193	negative regulation of DNA recombination
ACH33_RS03650	COG3766	membrane
ACH33_RS03655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACH33_RS03665	COG1279	arginine transmembrane transporter activity
ACH33_RS03670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACH33_RS03710	COG0728	peptidoglycan biosynthetic process
ACH33_RS03715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACH33_RS03725	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS03730	COG0506	proline dehydrogenase activity
ACH33_RS03735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACH33_RS03740	COG4572	Cation transport regulator
ACH33_RS03755	COG3278	Belongs to the heme-copper respiratory oxidase family
ACH33_RS03760	COG1309	transcriptional regulator
ACH33_RS03765	COG1024	Enoyl-CoA hydratase
ACH33_RS03770	COG2086	electron transfer activity
ACH33_RS03775	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACH33_RS03780	COG3118	belongs to the thioredoxin family
ACH33_RS03785	COG0322	excinuclease ABC activity
ACH33_RS03795	COG1268	BioY protein
ACH33_RS03800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACH33_RS03805	COG2009	succinate dehydrogenase
ACH33_RS03810	COG1053	succinate dehydrogenase
ACH33_RS03815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACH33_RS03820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACH33_RS03835	COG2197	response regulator
ACH33_RS03840	COG1191	sigma factor activity
ACH33_RS03845	COG2172	sigma factor antagonist activity
ACH33_RS03850	COG3284	Transcriptional regulator
ACH33_RS03855	COG0321	lipoyl(octanoyl) transferase activity
ACH33_RS03860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACH33_RS03865	COG0022	dehydrogenase e1 component
ACH33_RS03870	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACH33_RS03875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACH33_RS03880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACH33_RS03885	COG1063	alcohol dehydrogenase
ACH33_RS03890	COG2197	response regulator
ACH33_RS03900	COG5401	PFAM Sporulation and spore germination
ACH33_RS03905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACH33_RS03910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACH33_RS03925	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACH33_RS03930	COG0740	serine-type endopeptidase activity
ACH33_RS03935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACH33_RS03940	COG1067	ATP-dependent peptidase activity
ACH33_RS03940	COG0470	DNA polymerase III
ACH33_RS03950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACH33_RS03965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACH33_RS03970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACH33_RS03975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACH33_RS03980	COG0181	hydroxymethylbilane synthase activity
ACH33_RS03990	COG0113	porphobilinogen synthase activity
ACH33_RS03995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACH33_RS04000	COG1388	LysM domain
ACH33_RS04000	COG1388	LysM domain
ACH33_RS04045	COG1136	(ABC) transporter
ACH33_RS04050	COG0525	valine-tRNA ligase activity
ACH33_RS04055	COG0285	dihydrofolate synthase activity
ACH33_RS04060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACH33_RS04065	COG0840	transmembrane signaling receptor activity
ACH33_RS04105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACH33_RS04115	COG1459	type II secretion system
ACH33_RS04125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACH33_RS04150	COG0424	maF-like protein
ACH33_RS04155	COG2003	Belongs to the UPF0758 family
ACH33_RS04160	COG1077	Cell shape determining protein MreB Mrl
ACH33_RS04175	COG0850	regulation of cytokinetic process
ACH33_RS04180	COG2894	cell division
ACH33_RS04185	COG0772	Belongs to the SEDS family
ACH33_RS04195	COG1994	Peptidase M50
ACH33_RS04200	COG1530	ribonuclease E activity
ACH33_RS04205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACH33_RS04210	COG2868	ribosomal protein
ACH33_RS04215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACH33_RS04220	COG0028	Belongs to the TPP enzyme family
ACH33_RS04225	COG3290	protein histidine kinase activity
ACH33_RS04230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACH33_RS04235	COG4492	Belongs to the UPF0735 family
ACH33_RS04240	COG0460	homoserine dehydrogenase
ACH33_RS04245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACH33_RS04250	COG0083	homoserine kinase activity
ACH33_RS04255	COG0077	Prephenate dehydratase
ACH33_RS04260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACH33_RS04265	COG0217	transcriptional regulatory protein
ACH33_RS04285	COG0632	four-way junction helicase activity
ACH33_RS04290	COG2255	four-way junction helicase activity
ACH33_RS04300	COG2364	Membrane
ACH33_RS04305	COG1846	Transcriptional regulator
ACH33_RS04315	COG2385	sporulation resulting in formation of a cellular spore
ACH33_RS04315	COG2247	cell wall binding repeat
ACH33_RS04320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACH33_RS04325	COG0343	queuine tRNA-ribosyltransferase activity
ACH33_RS04330	COG1862	Preprotein translocase
ACH33_RS04340	COG0598	Magnesium transport protein CorA
ACH33_RS04345	COG2244	polysaccharide biosynthetic process
ACH33_RS04375	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ACH33_RS04375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACH33_RS04380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACH33_RS04385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACH33_RS04395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACH33_RS04405	COG0124	histidyl-tRNA synthetase
ACH33_RS04410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACH33_RS04420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACH33_RS04430	COG1959	2 iron, 2 sulfur cluster binding
ACH33_RS04435	COG1104	cysteine desulfurase activity
ACH33_RS04470	COG0628	permease
ACH33_RS04475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACH33_RS04480	COG4472	Bacterial protein of unknown function (DUF965)
ACH33_RS04490	COG3906	Belongs to the UPF0473 family
ACH33_RS04510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACH33_RS04515	COG4122	O-methyltransferase activity
ACH33_RS04520	COG0826	peptidase U32
ACH33_RS04525	COG0826	peptidase U32
ACH33_RS04530	COG0572	uridine kinase
ACH33_RS04535	COG0768	penicillin binding
ACH33_RS04540	COG3253	May function as heme-dependent peroxidase
ACH33_RS04545	COG0789	Transcriptional regulator
ACH33_RS04590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACH33_RS04595	COG1131	(ABC) transporter
ACH33_RS04615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACH33_RS04630	COG0028	Belongs to the TPP enzyme family
ACH33_RS04650	COG0318	PFAM AMP-dependent synthetase and ligase
ACH33_RS04660	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS04665	COG0473	3-isopropylmalate dehydrogenase activity
ACH33_RS04670	COG3829	transcription factor binding
ACH33_RS04675	COG4638	Rieske (2fe-2S)
ACH33_RS04685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACH33_RS04700	COG3876	Protein conserved in bacteria
ACH33_RS04705	COG3853	Toxic anion resistance protein (TelA)
ACH33_RS04710	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ACH33_RS04715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ACH33_RS04720	COG2224	Isocitrate lyase
ACH33_RS04725	COG1380	Effector of murein hydrolase LrgA
ACH33_RS04730	COG1346	cytolysis
ACH33_RS04740	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS04745	COG4605	iron ion homeostasis
ACH33_RS04750	COG4604	ABC transporter, ATP-binding protein
ACH33_RS04755	COG4607	ABC-type enterochelin transport system periplasmic component
ACH33_RS04760	COG2217	Heavy metal translocating P-type atpase
ACH33_RS04765	COG0640	Transcriptional regulator
ACH33_RS04770	COG0675	Transposase, IS605 OrfB family
ACH33_RS04780	COG3852	Histidine kinase
ACH33_RS04785	COG2204	response regulator
ACH33_RS04790	COG0010	Belongs to the arginase family
ACH33_RS04795	COG0786	glutamate:sodium symporter activity
ACH33_RS04825	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACH33_RS04830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACH33_RS04935	COG3584	3D domain protein
ACH33_RS04935	COG1388	LysM domain
ACH33_RS04945	COG1271	oxidase subunit
ACH33_RS04950	COG1294	oxidase, subunit
ACH33_RS04970	COG1027	Aspartate ammonia-lyase
ACH33_RS04980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ACH33_RS04985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACH33_RS04990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACH33_RS05000	COG2045	Belongs to the ComB family
ACH33_RS05030	COG0778	Nitroreductase
ACH33_RS05035	COG4187	Peptidase family M20/M25/M40
ACH33_RS05040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACH33_RS05045	COG0765	amino acid transport
ACH33_RS05050	COG1126	abc transporter atp-binding protein
ACH33_RS05060	COG3949	Membrane
ACH33_RS05065	COG0681	Belongs to the peptidase S26 family
ACH33_RS05070	COG1597	lipid kinase activity
ACH33_RS05075	COG0398	Pfam SNARE associated Golgi protein
ACH33_RS05080	COG2267	carboxylic ester hydrolase activity
ACH33_RS05095	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACH33_RS05115	COG1966	Carbon starvation protein
ACH33_RS05130	COG3279	Response regulator of the LytR AlgR family
ACH33_RS05135	COG3275	phosphorelay sensor kinase activity
ACH33_RS05140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACH33_RS05150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ACH33_RS05155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ACH33_RS05160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACH33_RS05165	COG1534	Rna-binding protein
ACH33_RS05170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACH33_RS05175	COG1713	HD superfamily hydrolase involved in NAD metabolism
ACH33_RS05180	COG0799	negative regulation of ribosome biogenesis
ACH33_RS05185	COG2226	methyltransferase
ACH33_RS05190	COG0495	leucyl-tRNA aminoacylation
ACH33_RS05195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACH33_RS05205	COG1555	photosystem II stabilization
ACH33_RS05205	COG1596	polysaccharide export
ACH33_RS05230	COG0658	competence protein
ACH33_RS05230	COG2333	competence protein COMEC
ACH33_RS05235	COG1595	DNA-templated transcription, initiation
ACH33_RS05245	COG1466	dna polymerase III delta subunit
ACH33_RS05250	COG0268	Binds directly to 16S ribosomal RNA
ACH33_RS05260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACH33_RS05265	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACH33_RS05280	COG0481	GTPase activity
ACH33_RS05285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACH33_RS05290	COG1420	regulation of RNA biosynthetic process
ACH33_RS05295	COG0459	protein refolding
ACH33_RS05315	COG2264	protein methyltransferase activity
ACH33_RS05320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACH33_RS05325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACH33_RS05330	COG3290	protein histidine kinase activity
ACH33_RS05335	COG4565	transcriptional regulatory protein
ACH33_RS05340	COG1301	dicarboxylic acid transport
ACH33_RS05345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACH33_RS05355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACH33_RS05360	COG1283	sodium-dependent phosphate transmembrane transporter activity
ACH33_RS05375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACH33_RS05375	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ACH33_RS05395	COG1595	DNA-templated transcription, initiation
ACH33_RS05415	COG2814	Major facilitator Superfamily
ACH33_RS05425	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS05430	COG2733	membrane
ACH33_RS05435	COG4191	Histidine kinase
ACH33_RS05440	COG0784	Response regulator, receiver
ACH33_RS05445	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACH33_RS05450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACH33_RS05455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACH33_RS05460	COG1610	YqeY-like protein
ACH33_RS05475	COG1702	phosphate starvation-inducible protein PhoH
ACH33_RS05480	COG1480	7TM receptor with intracellular HD hydrolase
ACH33_RS05485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACH33_RS05490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACH33_RS05495	COG0295	cytidine deaminase activity
ACH33_RS05500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACH33_RS05505	COG1381	Involved in DNA repair and RecF pathway recombination
ACH33_RS05510	COG0752	glycyl-tRNA synthetase alpha subunit
ACH33_RS05515	COG0751	glycine-tRNA ligase activity
ACH33_RS05520	COG0517	IMP dehydrogenase activity
ACH33_RS05525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ACH33_RS05535	COG0358	DNA primase activity
ACH33_RS05540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACH33_RS05550	COG1960	acyl-CoA dehydrogenase activity
ACH33_RS05555	COG0318	PFAM AMP-dependent synthetase and ligase
ACH33_RS05570	COG2384	SAM-dependent methyltransferase
ACH33_RS05575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACH33_RS05595	COG2843	Capsule synthesis protein
ACH33_RS05605	COG0312	modulator of DNA gyrase
ACH33_RS05610	COG0312	modulator of DNA gyrase
ACH33_RS05615	COG2827	Endonuclease containing a URI domain
ACH33_RS05660	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACH33_RS05675	COG0471	metal ion transport
ACH33_RS05700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACH33_RS05705	COG2814	Major facilitator Superfamily
ACH33_RS05720	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
ACH33_RS05730	COG2031	fatty acid transporter
ACH33_RS05735	COG4977	sequence-specific DNA binding
ACH33_RS05740	COG0010	Belongs to the arginase family
ACH33_RS05750	COG1228	amidohydrolase
ACH33_RS05760	COG1802	Transcriptional regulator
ACH33_RS05770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACH33_RS05775	COG2814	Major facilitator Superfamily
ACH33_RS05795	COG1876	peptidase activity
ACH33_RS05800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACH33_RS05810	COG0531	amino acid
ACH33_RS05830	COG4838	Belongs to the UPF0358 family
ACH33_RS05835	COG4637	Psort location Cytoplasmic, score
ACH33_RS05840	COG0783	Belongs to the Dps family
ACH33_RS05845	COG2217	Heavy metal translocating P-type atpase
ACH33_RS05850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACH33_RS05865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACH33_RS05870	COG0584	glycerophosphoryl diester phosphodiesterase
ACH33_RS05880	COG1733	regulation of RNA biosynthetic process
ACH33_RS05895	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ACH33_RS05910	COG1114	Component of the transport system for branched-chain amino acids
ACH33_RS05925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACH33_RS05930	COG0351	phosphomethylpyrimidine kinase
ACH33_RS05955	COG1607	acyl-coa hydrolase
ACH33_RS05960	COG0390	transport system, permease component
ACH33_RS05965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACH33_RS05970	COG0457	Tetratricopeptide repeat
ACH33_RS05970	COG0705	Rhomboid family
ACH33_RS05990	COG1363	Peptidase, m42
ACH33_RS06000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACH33_RS06005	COG0387	Pfam Sodium calcium exchanger
ACH33_RS06010	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACH33_RS06035	COG3119	arylsulfatase activity
ACH33_RS06040	COG0463	Glycosyl transferase, family 2
ACH33_RS06050	COG0640	Transcriptional regulator
ACH33_RS06080	COG3679	Belongs to the UPF0342 family
ACH33_RS06085	COG4471	UPF0298 protein
ACH33_RS06090	COG0589	response to stress
ACH33_RS06110	COG1459	type II secretion system
ACH33_RS06115	COG2165	general secretion pathway protein
ACH33_RS06140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACH33_RS06155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACH33_RS06160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACH33_RS06180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACH33_RS06185	COG0509	glycine decarboxylation via glycine cleavage system
ACH33_RS06190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACH33_RS06195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACH33_RS06200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACH33_RS06210	COG0095	Lipoate-protein ligase
ACH33_RS06220	COG2205	protein histidine kinase activity
ACH33_RS06225	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACH33_RS06230	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACH33_RS06240	COG5609	conserved protein (DUF2294)
ACH33_RS06245	COG3829	transcription factor binding
ACH33_RS06245	COG3290	protein histidine kinase activity
ACH33_RS06270	COG1666	GTP binding
ACH33_RS06280	COG1321	iron dependent repressor
ACH33_RS06285	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACH33_RS06295	COG3872	metal-dependent enzyme
ACH33_RS06300	COG2010	Cytochrome c
ACH33_RS06310	COG0006	proline dipeptidase activity
ACH33_RS06315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACH33_RS06320	COG2814	Major facilitator Superfamily
ACH33_RS06330	COG3854	ATPases associated with a variety of cellular activities
ACH33_RS06370	COG0511	ligase activity, forming carbon-carbon bonds
ACH33_RS06375	COG0439	Biotin carboxylase
ACH33_RS06380	COG1302	Protein conserved in bacteria
ACH33_RS06395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACH33_RS06400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACH33_RS06405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACH33_RS06410	COG1570	exodeoxyribonuclease VII activity
ACH33_RS06415	COG1722	exodeoxyribonuclease VII activity
ACH33_RS06425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACH33_RS06430	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ACH33_RS06435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACH33_RS06440	COG1438	arginine binding
ACH33_RS06445	COG0497	DNA recombination
ACH33_RS06450	COG0750	zinc metalloprotease
ACH33_RS06455	COG0745	RESPONSE REGULATOR receiver
ACH33_RS06465	COG0613	PHP domain protein
ACH33_RS06470	COG2153	protein acetylation
ACH33_RS06475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACH33_RS06525	COG1982	Orn Lys Arg decarboxylase major
ACH33_RS06535	COG4493	Belongs to the UPF0637 family
ACH33_RS06545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACH33_RS06555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACH33_RS06570	COG3829	transcription factor binding
ACH33_RS06570	COG3290	protein histidine kinase activity
ACH33_RS06590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACH33_RS06595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACH33_RS06620	COG1393	Belongs to the ArsC family
ACH33_RS06625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACH33_RS06630	COG1024	Enoyl-CoA hydratase
ACH33_RS06640	COG0439	Biotin carboxylase
ACH33_RS06645	COG0511	ligase activity, forming carbon-carbon bonds
ACH33_RS06650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACH33_RS06655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACH33_RS06660	COG1309	transcriptional regulator
ACH33_RS06665	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ACH33_RS06670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACH33_RS06680	COG0275	rRNA processing
ACH33_RS06690	COG0768	penicillin binding
ACH33_RS06695	COG0768	penicillin binding
ACH33_RS06705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACH33_RS06710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACH33_RS06715	COG0772	Belongs to the SEDS family
ACH33_RS06720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACH33_RS06725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACH33_RS06730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACH33_RS06735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACH33_RS06745	COG3879	Bacterial protein of unknown function (DUF881)
ACH33_RS06750	COG3856	small basic protein
ACH33_RS06755	COG0849	cell division
ACH33_RS06760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACH33_RS06770	COG1191	sigma factor activity
ACH33_RS06775	COG1191	sigma factor activity
ACH33_RS06785	COG1873	PFAM PRC-barrel domain
ACH33_RS06790	COG1496	oxidoreductase activity
ACH33_RS06795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACH33_RS06800	COG1799	cell septum assembly
ACH33_RS06805	COG0762	integral membrane protein
ACH33_RS06810	COG2302	S4 RNA-binding domain
ACH33_RS06815	COG3599	regulation of cell shape
ACH33_RS06820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACH33_RS06825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACH33_RS06830	COG0564	pseudouridine synthase activity
ACH33_RS06835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACH33_RS06845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACH33_RS06855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACH33_RS06860	COG0543	2 iron, 2 sulfur cluster binding
ACH33_RS06865	COG0167	dihydroorotate dehydrogenase activity
ACH33_RS06870	COG0284	orotidine-5'-phosphate decarboxylase activity
ACH33_RS06875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACH33_RS06880	COG2244	polysaccharide biosynthetic process
ACH33_RS06890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACH33_RS06895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACH33_RS06900	COG1561	YicC-like family, N-terminal region
ACH33_RS06905	COG2052	Domain of unknown function (DUF370)
ACH33_RS06910	COG0194	GDP metabolic process
ACH33_RS06915	COG1758	RNA polymerase activity
ACH33_RS06920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACH33_RS06925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACH33_RS06930	COG0242	peptide deformylase activity
ACH33_RS06935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACH33_RS06940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACH33_RS06940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACH33_RS06945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACH33_RS06950	COG0631	protein serine/threonine phosphatase activity
ACH33_RS06955	COG2815	serine threonine protein kinase
ACH33_RS06955	COG0515	serine threonine protein kinase
ACH33_RS06960	COG1162	GTPase activity
ACH33_RS06965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACH33_RS06970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACH33_RS06975	COG1760	l-serine dehydratase
ACH33_RS06980	COG1760	l-serine dehydratase
ACH33_RS06985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACH33_RS06990	COG1285	pathogenesis
ACH33_RS06995	COG0742	ribosomal rna small subunit methyltransferase
ACH33_RS07000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACH33_RS07005	COG3314	Sporulation integral membrane protein YlbJ
ACH33_RS07010	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACH33_RS07015	COG3480	Lon protease (S16) C-terminal proteolytic domain
ACH33_RS07020	COG1323	Belongs to the UPF0348 family
ACH33_RS07030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACH33_RS07050	COG0416	fatty acid biosynthetic process
ACH33_RS07060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACH33_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS07070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACH33_RS07075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACH33_RS07080	COG0571	ribonuclease III activity
ACH33_RS07085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACH33_RS07090	COG1196	nuclear chromosome segregation
ACH33_RS07095	COG0552	protein localization to endoplasmic reticulum
ACH33_RS07100	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ACH33_RS07105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACH33_RS07110	COG0228	four-way junction DNA binding
ACH33_RS07115	COG1837	Belongs to the UPF0109 family
ACH33_RS07125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACH33_RS07130	COG0336	Belongs to the RNA methyltransferase TrmD family
ACH33_RS07135	COG0335	large ribosomal subunit rRNA binding
ACH33_RS07140	COG0681	Belongs to the peptidase S26 family
ACH33_RS07150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACH33_RS07160	COG2257	FlhB HrpN YscU SpaS Family
ACH33_RS07165	COG0792	nuclease activity
ACH33_RS07180	COG0045	succinate-CoA ligase (ADP-forming) activity
ACH33_RS07185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACH33_RS07190	COG0758	DNA mediated transformation
ACH33_RS07190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACH33_RS07195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACH33_RS07200	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ACH33_RS07205	COG4974	Belongs to the 'phage' integrase family
ACH33_RS07210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACH33_RS07215	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACH33_RS07220	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ACH33_RS07225	COG1815	bacterial-type flagellum-dependent cell motility
ACH33_RS07230	COG1558	bacterial-type flagellum-dependent cell motility
ACH33_RS07235	COG1677	Flagellar hook-basal body complex protein FliE
ACH33_RS07240	COG1766	The M ring may be actively involved in energy transduction
ACH33_RS07245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACH33_RS07255	COG1157	protein secretion by the type III secretion system
ACH33_RS07260	COG2882	bacterial-type flagellum organization
ACH33_RS07270	COG3144	bacterial-type flagellum assembly
ACH33_RS07275	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ACH33_RS07285	COG4786	Flagellar basal body rod
ACH33_RS07290	COG1582	Flagellar protein (FlbD)
ACH33_RS07300	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACH33_RS07305	COG1776	CheC inhibitor of MCP methylation
ACH33_RS07305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACH33_RS07310	COG2201	protein-glutamate methylesterase activity
ACH33_RS07315	COG3190	flagellar
ACH33_RS07320	COG1338	Plays a role in the flagellum-specific transport system
ACH33_RS07325	COG1987	bacterial-type flagellum assembly
ACH33_RS07330	COG1684	flagellar biosynthetic protein fliR
ACH33_RS07335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACH33_RS07340	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACH33_RS07345	COG1419	protein localization to endoplasmic reticulum
ACH33_RS07350	COG0455	bacterial-type flagellum organization
ACH33_RS07355	COG2201	protein-glutamate methylesterase activity
ACH33_RS07360	COG2198	Histidine kinase
ACH33_RS07360	COG0643	Histidine kinase
ACH33_RS07365	COG0835	chemotaxis
ACH33_RS07370	COG1776	CheC inhibitor of MCP methylation
ACH33_RS07375	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACH33_RS07385	COG1191	sigma factor activity
ACH33_RS07405	COG0052	Belongs to the universal ribosomal protein uS2 family
ACH33_RS07410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACH33_RS07415	COG0528	UMP kinase activity
ACH33_RS07420	COG0233	cytoplasmic translational termination
ACH33_RS07425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACH33_RS07430	COG4589	Belongs to the CDS family
ACH33_RS07435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACH33_RS07440	COG0750	zinc metalloprotease
ACH33_RS07445	COG0442	prolyl-tRNA aminoacylation
ACH33_RS07450	COG2176	DNA-directed DNA polymerase activity
ACH33_RS07455	COG0779	Required for maturation of 30S ribosomal subunits
ACH33_RS07460	COG0195	Participates in both transcription termination and antitermination
ACH33_RS07465	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ACH33_RS07470	COG1358	cellular component organization or biogenesis
ACH33_RS07475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACH33_RS07480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACH33_RS07485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACH33_RS07490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACH33_RS07495	COG0196	riboflavin kinase activity
ACH33_RS07500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACH33_RS07505	COG1185	polyribonucleotide nucleotidyltransferase activity
ACH33_RS07510	COG0726	polysaccharide deacetylase
ACH33_RS07515	COG0612	Peptidase, M16
ACH33_RS07520	COG0756	dUTP diphosphatase activity
ACH33_RS07530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACH33_RS07535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACH33_RS07540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACH33_RS07545	COG0527	aspartate kinase activity
ACH33_RS07550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACH33_RS07555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACH33_RS07560	COG0582	viral genome integration into host DNA
ACH33_RS07710	COG1484	DNA-dependent DNA replication
ACH33_RS07735	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ACH33_RS07805	COG2868	ribosomal protein
ACH33_RS07920	COG4824	toxin secretion phage lysis holin
ACH33_RS07925	COG1876	peptidase activity
ACH33_RS07940	COG2801	Transposase and inactivated derivatives
ACH33_RS07975	COG2801	Transposase and inactivated derivatives
ACH33_RS07980	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ACH33_RS08010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACH33_RS08030	COG4191	Histidine kinase
ACH33_RS08045	COG1215	transferase activity, transferring glycosyl groups
ACH33_RS08050	COG0346	lactoylglutathione lyase activity
ACH33_RS08060	COG2076	Multidrug Resistance protein
ACH33_RS08065	COG2076	Multidrug Resistance protein
ACH33_RS08075	COG0697	spore germination
ACH33_RS08085	COG1114	Component of the transport system for branched-chain amino acids
ACH33_RS08090	COG1024	Enoyl-CoA hydratase
ACH33_RS08095	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ACH33_RS08105	COG1024	Enoyl-CoA hydratase
ACH33_RS08110	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACH33_RS08115	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACH33_RS08120	COG0183	Belongs to the thiolase family
ACH33_RS08125	COG0183	Belongs to the thiolase family
ACH33_RS08135	COG3396	Phenylacetate-CoA oxygenase
ACH33_RS08150	COG2151	metal-sulfur cluster biosynthetic enzyme
ACH33_RS08155	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS08165	COG0431	NADPH-dependent FMN reductase
ACH33_RS08190	COG2136	Putative SAM-dependent methyltransferase
ACH33_RS08190	COG2521	methyltransferase
ACH33_RS08195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACH33_RS08200	COG1923	regulation of RNA biosynthetic process
ACH33_RS08210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACH33_RS08215	COG2011	ABC-type metal ion transport system permease component
ACH33_RS08245	COG2340	Cysteine-rich secretory protein family
ACH33_RS08250	COG0464	growth
ACH33_RS08260	COG2814	Major facilitator Superfamily
ACH33_RS08265	COG1566	PFAM secretion protein HlyD family protein
ACH33_RS08270	COG1309	transcriptional regulator
ACH33_RS08280	COG2258	MOSC domain
ACH33_RS08290	COG0842	Transport permease protein
ACH33_RS08290	COG1131	(ABC) transporter
ACH33_RS08290	COG1716	ATPase activity
ACH33_RS08300	COG3335	DDE superfamily endonuclease
ACH33_RS08320	COG3335	DDE superfamily endonuclease
ACH33_RS08330	COG0716	FMN binding
ACH33_RS08340	COG3290	protein histidine kinase activity
ACH33_RS08350	COG0582	viral genome integration into host DNA
ACH33_RS08390	COG3693	PFAM glycoside hydrolase, family 10
ACH33_RS08395	COG2076	Multidrug Resistance protein
ACH33_RS08400	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACH33_RS08405	COG4948	Mandelate Racemase Muconate Lactonizing
ACH33_RS08440	COG0840	transmembrane signaling receptor activity
ACH33_RS08455	COG3835	regulator
ACH33_RS08460	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS08465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACH33_RS08475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACH33_RS08490	COG1309	transcriptional regulator
ACH33_RS08560	COG5377	YqaJ viral recombinase family
ACH33_RS08565	COG3723	Recombinational DNA repair protein, rece pathway
ACH33_RS08615	COG2315	Protein conserved in bacteria
ACH33_RS08630	COG5484	DNA packaging
ACH33_RS08630	COG3728	DNA packaging
ACH33_RS08635	COG1783	phage Terminase large subunit
ACH33_RS08735	COG3299	homolog of phage Mu protein gp47
ACH33_RS08760	COG4824	toxin secretion phage lysis holin
ACH33_RS08765	COG1876	peptidase activity
ACH33_RS08775	COG5002	protein histidine kinase activity
ACH33_RS08785	COG1984	allophanate hydrolase subunit 2
ACH33_RS08795	COG0439	Biotin carboxylase
ACH33_RS08800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACH33_RS08805	COG3829	transcription factor binding
ACH33_RS08805	COG3290	protein histidine kinase activity
ACH33_RS08815	COG1984	allophanate hydrolase subunit 2
ACH33_RS08825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACH33_RS08830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACH33_RS08840	COG0438	transferase activity, transferring glycosyl groups
ACH33_RS08845	COG0438	transferase activity, transferring glycosyl groups
ACH33_RS08850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACH33_RS08870	COG1294	oxidase, subunit
ACH33_RS08875	COG1271	oxidase subunit
ACH33_RS08885	COG1309	transcriptional regulator
ACH33_RS08900	COG1378	Sugar-specific transcriptional regulator TrmB
ACH33_RS08915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACH33_RS08915	COG2207	Transcriptional regulator
ACH33_RS08920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACH33_RS08925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS08930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS08935	COG2819	hydrolase of the alpha beta superfamily
ACH33_RS08940	COG0778	Nitroreductase
ACH33_RS08950	COG1840	ABC-type Fe3 transport system, periplasmic component
ACH33_RS08955	COG3842	ATPase activity
ACH33_RS08965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACH33_RS08980	COG1349	DNA-binding transcription factor activity
ACH33_RS08985	COG0534	Mate efflux family protein
ACH33_RS08995	COG2814	Major facilitator Superfamily
ACH33_RS09005	COG1809	phosphosulfolactate synthase activity
ACH33_RS09010	COG2814	Major facilitator Superfamily
ACH33_RS09015	COG2707	UPF0756 membrane protein
ACH33_RS09020	COG2045	Belongs to the ComB family
ACH33_RS09035	COG0247	lactate metabolic process
ACH33_RS09040	COG1139	Iron-sulfur cluster binding protein
ACH33_RS09045	COG1556	Lactate utilization protein
ACH33_RS09050	COG0697	spore germination
ACH33_RS09055	COG0531	amino acid
ACH33_RS09070	COG1764	response to oxidative stress
ACH33_RS09080	COG0833	amino acid
ACH33_RS09100	COG0835	chemotaxis
ACH33_RS09100	COG0784	Response regulator, receiver
ACH33_RS09115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACH33_RS09120	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ACH33_RS09125	COG0789	Transcriptional regulator
ACH33_RS09130	COG0174	glutamine synthetase
ACH33_RS09140	COG0745	RESPONSE REGULATOR receiver
ACH33_RS09175	COG1132	(ABC) transporter
ACH33_RS09185	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ACH33_RS09190	COG1122	ATPase activity
ACH33_RS09195	COG4721	ABC-type cobalt transport system, permease component
ACH33_RS09200	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ACH33_RS09205	COG0730	response to heat
ACH33_RS09210	COG3850	Histidine kinase
ACH33_RS09215	COG2197	response regulator
ACH33_RS09235	COG1131	(ABC) transporter
ACH33_RS09250	COG0488	(ABC) transporter
ACH33_RS09270	COG1331	Highly conserved protein containing a thioredoxin domain
ACH33_RS09275	COG1331	Highly conserved protein containing a thioredoxin domain
ACH33_RS09295	COG0671	phosphoesterase, PA-phosphatase related
ACH33_RS09300	COG0586	Pfam SNARE associated Golgi protein
ACH33_RS09305	COG0438	transferase activity, transferring glycosyl groups
ACH33_RS09310	COG1215	transferase activity, transferring glycosyl groups
ACH33_RS09320	COG1331	Highly conserved protein containing a thioredoxin domain
ACH33_RS09325	COG0393	Putative heavy-metal-binding
ACH33_RS09330	COG4086	secreted protein
ACH33_RS09335	COG0460	homoserine dehydrogenase
ACH33_RS09345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ACH33_RS09350	COG0427	acetyl-CoA hydrolase
ACH33_RS09365	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACH33_RS09380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACH33_RS09390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACH33_RS09395	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACH33_RS09400	COG1376	ErfK ybiS ycfS ynhG family protein
ACH33_RS09405	COG0183	Belongs to the thiolase family
ACH33_RS09420	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACH33_RS09425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACH33_RS09435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACH33_RS09440	COG0746	molybdenum cofactor guanylyltransferase activity
ACH33_RS09445	COG0303	'Molybdopterin
ACH33_RS09450	COG1763	Mo-molybdopterin cofactor biosynthetic process
ACH33_RS09455	COG0314	molybdopterin synthase activity
ACH33_RS09485	COG0488	(ABC) transporter
ACH33_RS09490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACH33_RS09505	COG0583	DNA-binding transcription factor activity
ACH33_RS09510	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACH33_RS09520	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ACH33_RS09525	COG0243	molybdopterin cofactor binding
ACH33_RS09530	COG0561	phosphatase activity
ACH33_RS09550	COG0189	ligase activity
ACH33_RS09560	COG3949	Membrane
ACH33_RS09565	COG4709	membrane
ACH33_RS09570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACH33_RS09580	COG0741	lytic transglycosylase activity
ACH33_RS09590	COG1802	Transcriptional regulator
ACH33_RS09595	COG1611	Belongs to the LOG family
ACH33_RS09600	COG5018	Exonuclease
ACH33_RS09610	COG1346	cytolysis
ACH33_RS09615	COG1380	Effector of murein hydrolase LrgA
ACH33_RS09620	COG0583	DNA-binding transcription factor activity
ACH33_RS09640	COG1404	Belongs to the peptidase S8 family
ACH33_RS09650	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS09660	COG1401	restriction endodeoxyribonuclease activity
ACH33_RS09660	COG1401	restriction endodeoxyribonuclease activity
ACH33_RS09670	COG0640	Transcriptional regulator
ACH33_RS09675	COG0798	PFAM Bile acid sodium symporter
ACH33_RS09680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACH33_RS09685	COG1252	NADH dehydrogenase
ACH33_RS09690	COG0791	NLP P60 protein
ACH33_RS09690	COG1388	LysM domain
ACH33_RS09695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACH33_RS09700	COG4224	UPF0291 protein
ACH33_RS09715	COG0840	transmembrane signaling receptor activity
ACH33_RS09730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACH33_RS09770	COG2211	Major facilitator Superfamily
ACH33_RS09780	COG0277	FAD linked oxidase domain protein
ACH33_RS09785	COG0247	lactate metabolic process
ACH33_RS09790	COG0277	FAD linked oxidase domain protein
ACH33_RS09795	COG2234	aminopeptidase activity
ACH33_RS09815	COG0084	hydrolase, TatD family'
ACH33_RS09820	COG1547	Domain of unknown function (DUF309)
ACH33_RS09825	COG3540	Alkaline phosphatase
ACH33_RS09835	COG3584	3D domain protein
ACH33_RS09835	COG1388	LysM domain
ACH33_RS09840	COG1074	ATP-dependent DNA helicase activity
ACH33_RS09845	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ACH33_RS09850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACH33_RS09855	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACH33_RS09860	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS09870	COG0534	Mate efflux family protein
ACH33_RS09875	COG0840	transmembrane signaling receptor activity
ACH33_RS09885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACH33_RS09895	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ACH33_RS09900	COG1607	acyl-coa hydrolase
ACH33_RS09905	COG0551	DNA topoisomerase type I activity
ACH33_RS09905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACH33_RS09910	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACH33_RS09915	COG1113	amino acid transport
ACH33_RS09920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACH33_RS09925	COG0686	Belongs to the AlaDH PNT family
ACH33_RS09930	COG4869	propanediol catabolic process
ACH33_RS09945	COG2186	Transcriptional regulator
ACH33_RS09950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACH33_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS09965	COG0644	oxidoreductase
ACH33_RS09975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACH33_RS09980	COG3048	D-serine ammonia-lyase activity
ACH33_RS09985	COG1309	transcriptional regulator
ACH33_RS09990	COG3844	kynureninase activity
ACH33_RS10000	COG3483	tryptophan 2,3-dioxygenase activity
ACH33_RS10005	COG0733	neurotransmitter:sodium symporter activity
ACH33_RS10025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACH33_RS10045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACH33_RS10060	COG2801	Transposase and inactivated derivatives
ACH33_RS10080	COG0582	viral genome integration into host DNA
ACH33_RS10090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ACH33_RS10095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACH33_RS10100	COG0697	spore germination
ACH33_RS10105	COG0583	DNA-binding transcription factor activity
ACH33_RS10115	COG2807	transmembrane transport
ACH33_RS10120	COG2186	Transcriptional regulator
ACH33_RS10125	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACH33_RS10150	COG2608	mercury ion transmembrane transporter activity
ACH33_RS10160	COG2217	Heavy metal translocating P-type atpase
ACH33_RS10180	COG1401	restriction endodeoxyribonuclease activity
ACH33_RS10185	COG0419	ATPase involved in DNA repair
ACH33_RS10260	COG1363	Peptidase, m42
ACH33_RS10285	COG0180	Tryptophanyl-tRNA synthetase
ACH33_RS10290	COG0180	Tryptophanyl-tRNA synthetase
ACH33_RS10325	COG0527	aspartate kinase activity
ACH33_RS10335	COG3192	ethanolamine utilization protein
ACH33_RS10340	COG4302	ethanolamine ammonia-lyase activity
ACH33_RS10345	COG4303	Ethanolamine ammonia lyase large subunit
ACH33_RS10355	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ACH33_RS10370	COG1454	alcohol dehydrogenase
ACH33_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS10375	COG4816	utilization protein
ACH33_RS10380	COG4302	ethanolamine ammonia-lyase activity
ACH33_RS10385	COG4303	Ethanolamine ammonia lyase large subunit
ACH33_RS10390	COG4819	ethanolamine utilization protein
ACH33_RS10405	COG4917	ethanolamine utilization protein
ACH33_RS10410	COG4810	utilization protein
ACH33_RS10425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACH33_RS10430	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ACH33_RS10435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACH33_RS10445	COG2056	Na+-H+ antiporter family
ACH33_RS10450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACH33_RS10455	COG1164	Oligoendopeptidase f
ACH33_RS10460	COG0656	L-ascorbic acid biosynthetic process
ACH33_RS10465	COG0577	efflux transmembrane transporter activity
ACH33_RS10470	COG1136	(ABC) transporter
ACH33_RS10475	COG5002	protein histidine kinase activity
ACH33_RS10480	COG0745	RESPONSE REGULATOR receiver
ACH33_RS10485	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ACH33_RS10495	COG0833	amino acid
ACH33_RS10505	COG2084	Dehydrogenase
ACH33_RS10510	COG3773	Cell wall hydrolase
ACH33_RS10530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACH33_RS10535	COG1199	ATP-dependent helicase activity
ACH33_RS10550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACH33_RS10555	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ACH33_RS10555	COG0662	Cupin 2, conserved barrel domain protein
ACH33_RS10565	COG0457	Tetratricopeptide repeat
ACH33_RS10565	COG0463	Glycosyl transferase, family 2
ACH33_RS10570	COG0463	Glycosyl transferase, family 2
ACH33_RS10570	COG0457	Tetratricopeptide repeat
ACH33_RS10620	COG2002	toxin-antitoxin pair type II binding
ACH33_RS10635	COG2843	Capsule synthesis protein
ACH33_RS10640	COG0583	DNA-binding transcription factor activity
ACH33_RS10645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACH33_RS10650	COG0066	3-isopropylmalate dehydratase activity
ACH33_RS10660	COG1164	Oligoendopeptidase f
ACH33_RS10665	COG0540	Belongs to the ATCase OTCase family
ACH33_RS10670	COG1098	S1 RNA binding domain
ACH33_RS10675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACH33_RS10680	COG0187	DNA topoisomerase II activity
ACH33_RS10685	COG0352	thiamine-phosphate diphosphorylase activity
ACH33_RS10690	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ACH33_RS10700	COG0506	proline dehydrogenase activity
ACH33_RS10710	COG1454	alcohol dehydrogenase
ACH33_RS10725	COG3852	Histidine kinase
ACH33_RS10730	COG2204	response regulator
ACH33_RS10755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACH33_RS10760	COG1482	cell wall glycoprotein biosynthetic process
ACH33_RS10765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACH33_RS10775	COG1506	peptidase
ACH33_RS10780	COG3858	chitin binding
ACH33_RS10780	COG1388	LysM domain
ACH33_RS10785	COG2962	Rard protein
ACH33_RS10805	COG2885	chlorophyll binding
ACH33_RS10830	COG1396	sequence-specific DNA binding
ACH33_RS10845	COG1388	LysM domain
ACH33_RS10845	COG3858	chitin binding
ACH33_RS10855	COG0671	phosphoesterase, PA-phosphatase related
ACH33_RS10860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACH33_RS10865	COG2247	cell wall binding repeat
ACH33_RS10865	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACH33_RS10870	COG1164	Oligoendopeptidase f
ACH33_RS10875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACH33_RS10885	COG0318	PFAM AMP-dependent synthetase and ligase
ACH33_RS10890	COG1960	acyl-CoA dehydrogenase activity
ACH33_RS10895	COG0183	Belongs to the thiolase family
ACH33_RS10900	COG1024	Enoyl-CoA hydratase
ACH33_RS10900	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACH33_RS10915	COG0653	protein targeting
ACH33_RS10920	COG2996	Protein conserved in bacteria
ACH33_RS10925	COG0210	DNA helicase
ACH33_RS10930	COG0427	acetyl-CoA hydrolase
ACH33_RS10950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ACH33_RS10960	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ACH33_RS10965	COG0517	IMP dehydrogenase activity
ACH33_RS10970	COG4980	gas vesicle protein
ACH33_RS10970	COG1674	ftsk spoiiie
ACH33_RS10975	COG1595	DNA-templated transcription, initiation
ACH33_RS10985	COG1131	(ABC) transporter
ACH33_RS11000	COG0442	prolyl-tRNA aminoacylation
ACH33_RS11035	COG3655	Transcriptional regulator
ACH33_RS11065	COG0582	viral genome integration into host DNA
ACH33_RS11075	COG0740	serine-type endopeptidase activity
ACH33_RS11080	COG0586	Pfam SNARE associated Golgi protein
ACH33_RS11105	COG1950	PFAM Membrane protein of
ACH33_RS11110	COG3723	Recombinational DNA repair protein, rece pathway
ACH33_RS11115	COG5377	YqaJ viral recombinase family
ACH33_RS11120	COG1396	sequence-specific DNA binding
ACH33_RS11125	COG0252	asparaginase activity
ACH33_RS11130	COG1115	amino acid carrier protein
ACH33_RS11140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACH33_RS11145	COG3829	transcription factor binding
ACH33_RS11150	COG1686	Belongs to the peptidase S11 family
ACH33_RS11155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACH33_RS11160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACH33_RS11170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS11175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACH33_RS11185	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACH33_RS11190	COG1408	metallophosphoesterase
ACH33_RS11195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACH33_RS11200	COG0726	polysaccharide deacetylase
ACH33_RS11235	COG0739	heme binding
ACH33_RS11255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACH33_RS11275	COG0189	ligase activity
ACH33_RS11275	COG0569	domain protein
ACH33_RS11285	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACH33_RS11295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACH33_RS11310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACH33_RS11315	COG0602	queuosine metabolic process
ACH33_RS11335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACH33_RS11340	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS11360	COG3829	transcription factor binding
ACH33_RS11360	COG3290	protein histidine kinase activity
ACH33_RS11365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACH33_RS11370	COG3938	Belongs to the proline racemase family
ACH33_RS11375	COG0531	amino acid
ACH33_RS11385	COG5002	protein histidine kinase activity
ACH33_RS11390	COG0745	RESPONSE REGULATOR receiver
ACH33_RS11395	COG2132	Multicopper oxidase
ACH33_RS11400	COG2217	Heavy metal translocating P-type atpase
ACH33_RS11450	COG2091	lysine biosynthetic process via aminoadipic acid
ACH33_RS11455	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ACH33_RS11465	COG0109	protoheme IX farnesyltransferase activity
ACH33_RS11470	COG1063	alcohol dehydrogenase
ACH33_RS11495	COG1151	hydroxylamine reductase activity
ACH33_RS11500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACH33_RS11540	COG2267	carboxylic ester hydrolase activity
ACH33_RS11560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACH33_RS11560	COG0473	3-isopropylmalate dehydrogenase activity
ACH33_RS11575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACH33_RS11590	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ACH33_RS11595	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACH33_RS11670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACH33_RS11675	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACH33_RS11710	COG3971	2-oxopent-4-enoate hydratase activity
ACH33_RS11720	COG0251	oxidation-reduction process
ACH33_RS11735	COG2368	4-hydroxyphenylacetate
ACH33_RS11895	COG0484	heat shock protein binding
ACH33_RS11910	COG0515	serine threonine protein kinase
ACH33_RS11910	COG3266	domain, Protein
ACH33_RS11935	COG1131	(ABC) transporter
ACH33_RS11945	COG4550	Control of competence regulator ComK, YlbF/YmcA
ACH33_RS11950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACH33_RS11965	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ACH33_RS11970	COG1234	tRNA 3'-trailer cleavage
ACH33_RS11975	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACH33_RS11980	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACH33_RS11980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACH33_RS11985	COG2359	stage V sporulation protein S
ACH33_RS11990	COG1692	metallophosphoesterase
ACH33_RS11995	COG1418	mRNA catabolic process
ACH33_RS12000	COG2137	regulation of response to DNA damage stimulus
ACH33_RS12005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACH33_RS12015	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACH33_RS12020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACH33_RS12025	COG0513	Belongs to the DEAD box helicase family
ACH33_RS12030	COG1546	Belongs to the CinA family
ACH33_RS12030	COG1058	Belongs to the CinA family
ACH33_RS12035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACH33_RS12040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACH33_RS12045	COG1426	Protein conserved in bacteria
ACH33_RS12060	COG0300	oxidoreductase activity
ACH33_RS12065	COG0612	Peptidase, M16
ACH33_RS12070	COG0612	Peptidase, M16
ACH33_RS12085	COG0515	serine threonine protein kinase
ACH33_RS12090	COG1132	(ABC) transporter
ACH33_RS12100	COG0574	Belongs to the PEP-utilizing enzyme family
ACH33_RS12100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACH33_RS12110	COG2801	Transposase and inactivated derivatives
ACH33_RS12120	COG3935	DnaD domain protein
ACH33_RS12130	COG0436	Aminotransferase
ACH33_RS12135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACH33_RS12145	COG0675	Transposase, IS605 OrfB family
ACH33_RS12160	COG0402	S-adenosylhomocysteine deaminase activity
ACH33_RS12165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ACH33_RS12170	COG1199	ATP-dependent helicase activity
ACH33_RS12170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACH33_RS12180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACH33_RS12185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACH33_RS12190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACH33_RS12195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ACH33_RS12195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ACH33_RS12200	COG0617	tRNA 3'-terminal CCA addition
ACH33_RS12205	COG0438	transferase activity, transferring glycosyl groups
ACH33_RS12210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ACH33_RS12215	COG1803	Methylglyoxal synthase
ACH33_RS12220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACH33_RS12225	COG1694	Mazg nucleotide pyrophosphohydrolase
ACH33_RS12230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACH33_RS12285	COG1595	DNA-templated transcription, initiation
ACH33_RS12305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACH33_RS12310	COG0287	Prephenate dehydrogenase
ACH33_RS12315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACH33_RS12320	COG0159	tryptophan synthase activity
ACH33_RS12325	COG0133	tryptophan synthase activity
ACH33_RS12330	COG0135	phosphoribosylanthranilate isomerase activity
ACH33_RS12335	COG0134	indole-3-glycerol-phosphate synthase activity
ACH33_RS12340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACH33_RS12355	COG4401	Chorismate mutase type I
ACH33_RS12360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACH33_RS12365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACH33_RS12370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACH33_RS12375	COG0105	UTP biosynthetic process
ACH33_RS12390	COG0163	prenyltransferase activity
ACH33_RS12395	COG0109	protoheme IX farnesyltransferase activity
ACH33_RS12400	COG2226	methyltransferase
ACH33_RS12405	COG0142	geranyltranstransferase activity
ACH33_RS12415	COG0776	regulation of translation
ACH33_RS12425	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ACH33_RS12460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACH33_RS12465	COG1160	GTP binding
ACH33_RS12490	COG0539	negative regulation of cytoplasmic translation
ACH33_RS12500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACH33_RS12510	COG2959	enzyme of heme biosynthesis
ACH33_RS12515	COG2339	peptidase activity
ACH33_RS12520	COG0492	ferredoxin-NADP+ reductase activity
ACH33_RS12525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACH33_RS12530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACH33_RS12535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACH33_RS12540	COG3711	transcriptional antiterminator
ACH33_RS12545	COG0166	Belongs to the GPI family
ACH33_RS12550	COG0205	6-phosphofructokinase activity
ACH33_RS12555	COG2190	(PTS) system
ACH33_RS12555	COG1263	PTS System
ACH33_RS12555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACH33_RS12560	COG4862	establishment of competence for transformation
ACH33_RS12565	COG2357	RelA SpoT domain protein
ACH33_RS12570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACH33_RS12575	COG0492	ferredoxin-NADP+ reductase activity
ACH33_RS12595	COG0514	ATP-dependent DNA helicase (RecQ)
ACH33_RS12600	COG4955	Helix-turn-helix domain
ACH33_RS12605	COG1141	Ferredoxin
ACH33_RS12615	COG0598	Magnesium transport protein CorA
ACH33_RS12635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACH33_RS12645	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS12650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACH33_RS12655	COG2050	protein possibly involved in aromatic compounds catabolism
ACH33_RS12660	COG5002	protein histidine kinase activity
ACH33_RS12665	COG0745	RESPONSE REGULATOR receiver
ACH33_RS12670	COG0824	Thioesterase
ACH33_RS12680	COG5002	protein histidine kinase activity
ACH33_RS12685	COG0745	RESPONSE REGULATOR receiver
ACH33_RS12695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACH33_RS12700	COG1333	cytochrome c biogenesis protein
ACH33_RS12705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACH33_RS12715	COG1187	pseudouridine synthase activity
ACH33_RS12720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACH33_RS12725	COG2190	(PTS) system
ACH33_RS12735	COG0363	glucosamine-6-phosphate deaminase activity
ACH33_RS12745	COG1263	PTS System
ACH33_RS12745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACH33_RS12745	COG2190	(PTS) system
ACH33_RS12750	COG0700	Nucleoside recognition
ACH33_RS12755	COG2715	membrane protein required for spore maturation
ACH33_RS12760	COG1686	Belongs to the peptidase S11 family
ACH33_RS12765	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACH33_RS12770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACH33_RS12775	COG1994	Peptidase M50
ACH33_RS12780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACH33_RS12785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACH33_RS12785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACH33_RS12795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACH33_RS12795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACH33_RS12800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACH33_RS12805	COG0579	oxidoreductase
ACH33_RS12820	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS12825	COG1113	amino acid transport
ACH33_RS12830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACH33_RS12840	COG0537	adenosine 5'-monophosphoramidase activity
ACH33_RS12845	COG0019	diaminopimelate decarboxylase activity
ACH33_RS12860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACH33_RS12885	COG2172	sigma factor antagonist activity
ACH33_RS12895	COG1686	Belongs to the peptidase S11 family
ACH33_RS12900	COG4608	Belongs to the ABC transporter superfamily
ACH33_RS12905	COG0444	Belongs to the ABC transporter superfamily
ACH33_RS12910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACH33_RS12915	COG0601	transmembrane transport
ACH33_RS12920	COG4166	transmembrane transport
ACH33_RS12925	COG1522	sequence-specific DNA binding
ACH33_RS12930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACH33_RS12940	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ACH33_RS12945	COG4974	Belongs to the 'phage' integrase family
ACH33_RS12955	COG0768	penicillin binding
ACH33_RS12960	COG0735	belongs to the Fur family
ACH33_RS12965	COG1300	Membrane
ACH33_RS12970	COG1379	DNA repair
ACH33_RS12975	COG0494	nUDIX hydrolase
ACH33_RS12985	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACH33_RS12990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACH33_RS12995	COG0346	lactoylglutathione lyase activity
ACH33_RS13000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACH33_RS13000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ACH33_RS13005	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACH33_RS13010	COG0022	dehydrogenase e1 component
ACH33_RS13015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACH33_RS13020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACH33_RS13025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACH33_RS13030	COG3290	protein histidine kinase activity
ACH33_RS13030	COG3829	transcription factor binding
ACH33_RS13045	COG0463	Glycosyl transferase, family 2
ACH33_RS13055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACH33_RS13070	COG1253	flavin adenine dinucleotide binding
ACH33_RS13075	COG2738	Putative neutral zinc metallopeptidase
ACH33_RS13080	COG0789	Transcriptional regulator
ACH33_RS13090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACH33_RS13100	COG0681	Belongs to the peptidase S26 family
ACH33_RS13105	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS13110	COG4848	Belongs to the UPF0354 family
ACH33_RS13125	COG1024	Enoyl-CoA hydratase
ACH33_RS13155	COG1392	Phosphate transport regulator
ACH33_RS13160	COG0306	phosphate transporter
ACH33_RS13175	COG2346	COG2346, Truncated hemoglobins
ACH33_RS13180	COG0741	lytic transglycosylase activity
ACH33_RS13185	COG0318	PFAM AMP-dependent synthetase and ligase
ACH33_RS13195	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACH33_RS13200	COG2205	protein histidine kinase activity
ACH33_RS13200	COG2202	Pas domain
ACH33_RS13210	COG2205	protein histidine kinase activity
ACH33_RS13210	COG5002	protein histidine kinase activity
ACH33_RS13210	COG0784	Response regulator, receiver
ACH33_RS13215	COG1744	ABC transporter substrate-binding protein PnrA-like
ACH33_RS13220	COG2204	response regulator
ACH33_RS13225	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ACH33_RS13225	COG0644	oxidoreductase
ACH33_RS13230	COG1309	transcriptional regulator
ACH33_RS13265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ACH33_RS13270	COG1131	(ABC) transporter
ACH33_RS13280	COG2423	ornithine cyclodeaminase activity
ACH33_RS13290	COG1476	TRANSCRIPTIONal
ACH33_RS13295	COG1396	sequence-specific DNA binding
ACH33_RS13300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACH33_RS13305	COG0166	Belongs to the GPI family
ACH33_RS13310	COG0205	6-phosphofructokinase activity
ACH33_RS13315	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ACH33_RS13325	COG0840	transmembrane signaling receptor activity
ACH33_RS13335	COG0477	Major facilitator Superfamily
ACH33_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS13350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACH33_RS13355	COG2610	gluconate transmembrane transporter activity
ACH33_RS13360	COG3829	transcription factor binding
ACH33_RS13360	COG3290	protein histidine kinase activity
ACH33_RS13365	COG0464	growth
ACH33_RS13405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACH33_RS13405	COG0165	Argininosuccinate lyase
ACH33_RS13415	COG1902	pentaerythritol trinitrate reductase activity
ACH33_RS13425	COG1122	ATPase activity
ACH33_RS13430	COG4120	Belongs to the binding-protein-dependent transport system permease family
ACH33_RS13440	COG0564	pseudouridine synthase activity
ACH33_RS13445	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ACH33_RS13450	COG3874	Sporulation protein YtfJ
ACH33_RS13465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACH33_RS13470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACH33_RS13475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACH33_RS13485	COG0861	Integral membrane protein TerC family
ACH33_RS13490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACH33_RS13505	COG0788	formyltetrahydrofolate deformylase activity
ACH33_RS13510	COG0302	gtp cyclohydrolase
ACH33_RS13545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACH33_RS13550	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACH33_RS13565	COG0004	ammonium transporteR
ACH33_RS13575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACH33_RS13585	COG2259	Doxx family
ACH33_RS13595	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ACH33_RS13605	COG2030	dehydratase
ACH33_RS13630	COG3243	poly(R)-hydroxyalkanoic acid synthase
ACH33_RS13635	COG0301	tRNA thio-modification
ACH33_RS13640	COG1104	cysteine desulfurase activity
ACH33_RS13660	COG1473	amidohydrolase
ACH33_RS13665	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS13670	COG0300	oxidoreductase activity
ACH33_RS13675	COG2155	Conserved Protein
ACH33_RS13680	COG0386	Belongs to the glutathione peroxidase family
ACH33_RS13685	COG0531	amino acid
ACH33_RS13690	COG1595	DNA-templated transcription, initiation
ACH33_RS13705	COG0644	oxidoreductase
ACH33_RS13710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACH33_RS13730	COG2081	HI0933 family
ACH33_RS13735	COG3162	membrane
ACH33_RS13740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACH33_RS13745	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ACH33_RS13750	COG1309	transcriptional regulator
ACH33_RS13760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACH33_RS13765	COG2203	Gaf domain
ACH33_RS13765	COG2199	diguanylate cyclase activity
ACH33_RS13775	COG0133	tryptophan synthase activity
ACH33_RS13785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACH33_RS13790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACH33_RS13795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACH33_RS13800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACH33_RS13805	COG0454	-acetyltransferase
ACH33_RS13810	COG0517	IMP dehydrogenase activity
ACH33_RS13815	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACH33_RS13820	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACH33_RS13835	COG1605	Chorismate mutase
ACH33_RS13835	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACH33_RS13845	COG3118	belongs to the thioredoxin family
ACH33_RS13860	COG0473	3-isopropylmalate dehydrogenase activity
ACH33_RS13880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACH33_RS13885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACH33_RS13895	COG0517	IMP dehydrogenase activity
ACH33_RS13925	COG3546	catalase activity
ACH33_RS13930	COG0778	Nitroreductase
ACH33_RS13935	COG3331	DNA recombination
ACH33_RS13945	COG0492	ferredoxin-NADP+ reductase activity
ACH33_RS14040	COG1686	Belongs to the peptidase S11 family
ACH33_RS14045	COG1028	Short-chain dehydrogenase reductase Sdr
ACH33_RS14055	COG0410	ABC transporter
ACH33_RS14060	COG0411	ABC transporter
ACH33_RS14090	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS14100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACH33_RS14110	COG0315	cyclic pyranopterin monophosphate synthase activity
ACH33_RS14115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACH33_RS14120	COG0697	spore germination
ACH33_RS14130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACH33_RS14140	COG1674	ftsk spoiiie
ACH33_RS14155	COG1297	OPT oligopeptide transporter protein
ACH33_RS14160	COG0129	dihydroxy-acid dehydratase activity
ACH33_RS14165	COG1376	ErfK ybiS ycfS ynhG family protein
ACH33_RS14170	COG2197	response regulator
ACH33_RS14175	COG4585	Histidine kinase
ACH33_RS14180	COG4758	membrane
ACH33_RS14190	COG1187	pseudouridine synthase activity
ACH33_RS14195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACH33_RS14195	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ACH33_RS14205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACH33_RS14215	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACH33_RS14220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACH33_RS14225	COG0602	queuosine metabolic process
ACH33_RS14230	COG0720	synthase
ACH33_RS14235	COG0483	inositol monophosphate 1-phosphatase activity
ACH33_RS14240	COG2226	methyltransferase
ACH33_RS14255	COG0861	Integral membrane protein TerC family
ACH33_RS14265	COG0352	thiamine-phosphate diphosphorylase activity
ACH33_RS14270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACH33_RS14275	COG2104	thiamine diphosphate biosynthetic process
ACH33_RS14280	COG2022	thiamine diphosphate biosynthetic process
ACH33_RS14290	COG1924	4 iron, 4 sulfur cluster binding
ACH33_RS14295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACH33_RS14310	COG2814	Major facilitator Superfamily
ACH33_RS14320	COG1408	metallophosphoesterase
ACH33_RS14335	COG1242	4 iron, 4 sulfur cluster binding
ACH33_RS14340	COG2707	UPF0756 membrane protein
ACH33_RS14345	COG1217	gtp-binding protein TYPA
ACH33_RS14350	COG1316	TRANSCRIPTIONal
ACH33_RS14355	COG2267	carboxylic ester hydrolase activity
ACH33_RS14385	COG1556	Lactate utilization protein
ACH33_RS14390	COG1139	Iron-sulfur cluster binding protein
ACH33_RS14445	COG0371	Dehydrogenase
ACH33_RS14450	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACH33_RS14460	COG2362	D-Aminopeptidase
ACH33_RS14470	COG1464	Belongs to the NlpA lipoprotein family
ACH33_RS14475	COG2011	ABC-type metal ion transport system permease component
ACH33_RS14510	COG1879	ABC-type sugar transport system periplasmic component
ACH33_RS14515	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACH33_RS14520	COG1129	ABC transporter
ACH33_RS14525	COG1869	D-ribose catabolic process
ACH33_RS14530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACH33_RS14535	COG1609	Transcriptional regulator
ACH33_RS14555	COG0688	phosphatidylethanolamine metabolic process
ACH33_RS14560	COG0702	epimerase
ACH33_RS14585	COG3335	DDE superfamily endonuclease
ACH33_RS14595	COG1832	CoA-binding protein
ACH33_RS14605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACH33_RS14615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACH33_RS14620	COG0840	transmembrane signaling receptor activity
ACH33_RS14625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACH33_RS14635	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
ACH33_RS14640	COG1484	DNA-dependent DNA replication
ACH33_RS14645	COG3611	Membrane attachment protein
ACH33_RS14650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACH33_RS14655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACH33_RS14660	COG1196	nuclear chromosome segregation
ACH33_RS14660	COG0741	lytic transglycosylase activity
ACH33_RS14660	COG0739	heme binding
ACH33_RS14665	COG0237	dephospho-CoA kinase activity
ACH33_RS14670	COG1971	Probably functions as a manganese efflux pump
ACH33_RS14675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACH33_RS14680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACH33_RS14680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACH33_RS14685	COG0330	HflC and HflK could
ACH33_RS14695	COG5002	protein histidine kinase activity
ACH33_RS14700	COG0745	RESPONSE REGULATOR receiver
ACH33_RS14720	COG0039	L-malate dehydrogenase activity
ACH33_RS14725	COG0538	isocitrate dehydrogenase activity
ACH33_RS14730	COG0372	Belongs to the citrate synthase family
ACH33_RS14740	COG0628	permease
ACH33_RS14745	COG3030	protein affecting phage T7 exclusion by the F plasmid
ACH33_RS14750	COG0824	Thioesterase
ACH33_RS14760	COG0825	malonyl-CoA metabolic process
ACH33_RS14765	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACH33_RS14775	COG2186	Transcriptional regulator
ACH33_RS14780	COG0281	malic enzyme
ACH33_RS14785	COG0587	DNA-directed DNA polymerase activity
ACH33_RS14810	COG4109	DRTGG domain
ACH33_RS14820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACH33_RS14830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACH33_RS14835	COG0189	ligase activity
ACH33_RS14840	COG0189	ligase activity
ACH33_RS14845	COG0189	ligase activity
ACH33_RS14865	COG1757	Na H antiporter
ACH33_RS14870	COG0436	Aminotransferase
ACH33_RS14875	COG1683	Conserved Protein
ACH33_RS14880	COG1937	Protein conserved in bacteria
ACH33_RS14890	COG1741	Belongs to the pirin family
ACH33_RS14910	COG3384	dioxygenase
ACH33_RS14920	COG2719	SpoVR family
ACH33_RS14935	COG3335	DDE superfamily endonuclease
ACH33_RS14945	COG1876	peptidase activity
ACH33_RS14950	COG4824	toxin secretion phage lysis holin
ACH33_RS15115	COG2766	serine protein kinase
ACH33_RS15125	COG1464	Belongs to the NlpA lipoprotein family
ACH33_RS15140	COG1714	RDD family
ACH33_RS15145	COG0616	signal peptide processing
ACH33_RS15155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACH33_RS15165	COG0328	RNA-DNA hybrid ribonuclease activity
ACH33_RS15175	COG2233	PERMEase
ACH33_RS15180	COG1573	uracil-dna glycosylase
ACH33_RS15190	COG1573	uracil-dna glycosylase
ACH33_RS15300	COG0735	belongs to the Fur family
ACH33_RS15340	COG2096	Adenosyltransferase
ACH33_RS15350	COG2226	methyltransferase
ACH33_RS15355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACH33_RS15385	COG4555	ABC transporter
ACH33_RS15390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACH33_RS15395	COG0069	glutamate synthase activity
ACH33_RS15395	COG0070	glutamate synthase
ACH33_RS15395	COG0067	glutamate synthase
ACH33_RS15405	COG1850	ribulose-bisphosphate carboxylase activity
ACH33_RS15410	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ACH33_RS15415	COG0235	Class ii aldolase
ACH33_RS15420	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ACH33_RS15425	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACH33_RS15430	COG1132	(ABC) transporter
ACH33_RS15435	COG3557	Belongs to the UPF0374 family
ACH33_RS15440	COG0456	acetyltransferase
ACH33_RS15460	COG0670	Belongs to the BI1 family
ACH33_RS15465	COG2814	Major facilitator Superfamily
ACH33_RS15470	COG0247	lactate metabolic process
ACH33_RS15475	COG0277	FAD linked oxidase domain protein
ACH33_RS15490	COG1988	membrane-bound metal-dependent
ACH33_RS15500	COG2340	Cysteine-rich secretory protein family
ACH33_RS15505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACH33_RS15510	COG0534	Mate efflux family protein
ACH33_RS15520	COG0529	Catalyzes the synthesis of activated sulfate
ACH33_RS15525	COG2046	Belongs to the sulfate adenylyltransferase family
ACH33_RS15530	COG0175	sulfate reduction
ACH33_RS15535	COG0306	phosphate transporter
ACH33_RS15545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACH33_RS15555	COG0577	efflux transmembrane transporter activity
ACH33_RS15560	COG1136	(ABC) transporter
ACH33_RS15570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACH33_RS15575	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS15580	COG3829	transcription factor binding
ACH33_RS15580	COG3290	protein histidine kinase activity
ACH33_RS15600	COG0697	spore germination
ACH33_RS15615	COG1929	Belongs to the glycerate kinase type-1 family
ACH33_RS15630	COG1183	phosphatidylcholine synthase activity
ACH33_RS15635	COG1113	amino acid transport
ACH33_RS15640	COG1960	acyl-CoA dehydrogenase activity
ACH33_RS15645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACH33_RS15660	COG4191	Histidine kinase
ACH33_RS15670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACH33_RS15675	COG0500	methyltransferase
ACH33_RS15675	COG3615	Tellurite resistance protein tehB
ACH33_RS15680	COG0827	DNA restriction-modification system
ACH33_RS15685	COG0827	DNA restriction-modification system
ACH33_RS15690	COG1280	lysine exporter protein (LysE YggA)
ACH33_RS15710	COG2801	Transposase and inactivated derivatives
ACH33_RS15725	COG3335	DDE superfamily endonuclease
ACH33_RS15730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACH33_RS15750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ACH33_RS15810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACH33_RS15815	COG4840	Belongs to the UPF0435 family
ACH33_RS15820	COG0733	neurotransmitter:sodium symporter activity
ACH33_RS15825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACH33_RS15835	COG0733	neurotransmitter:sodium symporter activity
ACH33_RS15840	COG0598	Magnesium transport protein CorA
ACH33_RS15850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACH33_RS15855	COG2323	membrane
ACH33_RS15865	COG1131	(ABC) transporter
ACH33_RS15870	COG1132	(ABC) transporter
ACH33_RS15875	COG0535	radical SAM domain protein
ACH33_RS15880	COG2259	Doxx family
ACH33_RS15900	COG1823	symporter activity
ACH33_RS15905	COG0531	amino acid
ACH33_RS15915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACH33_RS15920	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
ACH33_RS15945	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ACH33_RS15960	COG1203	CRISPR-associated helicase, Cas3
ACH33_RS15985	COG3104	oligopeptide transport
ACH33_RS16015	COG3775	system Galactitol-specific IIC component
ACH33_RS16030	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ACH33_RS16090	COG1131	(ABC) transporter
ACH33_RS16095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACH33_RS16100	COG1597	lipid kinase activity
ACH33_RS16105	COG3852	Histidine kinase
ACH33_RS16110	COG1396	sequence-specific DNA binding
ACH33_RS16115	COG0247	lactate metabolic process
ACH33_RS16120	COG0277	FAD linked oxidase domain protein
ACH33_RS16125	COG2186	Transcriptional regulator
ACH33_RS16135	COG3706	GGDEF domain
ACH33_RS16140	COG0582	viral genome integration into host DNA
ACH33_RS16150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACH33_RS16155	COG0154	amidase activity
ACH33_RS16160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACH33_RS16165	COG0840	transmembrane signaling receptor activity
ACH33_RS16180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACH33_RS16185	COG0210	DNA helicase
ACH33_RS16200	COG1131	(ABC) transporter
ACH33_RS16220	COG4496	protein, YerC YecD
ACH33_RS16225	COG0675	Transposase, IS605 OrfB family
ACH33_RS16230	COG0840	transmembrane signaling receptor activity
ACH33_RS16235	COG1470	cell adhesion involved in biofilm formation
ACH33_RS16245	COG0411	ABC transporter
ACH33_RS16270	COG0151	Belongs to the GarS family
ACH33_RS16280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACH33_RS16285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACH33_RS16290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACH33_RS16295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACH33_RS16300	COG0047	phosphoribosylformylglycinamidine synthase activity
ACH33_RS16305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACH33_RS16310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACH33_RS16315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACH33_RS16320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACH33_RS16325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACH33_RS16330	COG3437	response regulator, receiver
ACH33_RS16335	COG2252	PERMEase
ACH33_RS16340	COG0519	Catalyzes the synthesis of GMP from XMP
ACH33_RS16340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACH33_RS16345	COG0459	protein refolding
ACH33_RS16350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACH33_RS16355	COG0805	protein transport
ACH33_RS16360	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACH33_RS16365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACH33_RS16370	COG0488	(ABC) transporter
ACH33_RS16385	COG0456	acetyltransferase
ACH33_RS16390	COG1214	PFAM Peptidase M22, glycoprotease
ACH33_RS16395	COG0802	atpase or kinase
ACH33_RS16400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACH33_RS16405	COG3091	SprT-like family
ACH33_RS16415	COG2183	response to ionizing radiation
ACH33_RS16420	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACH33_RS16425	COG0864	Transcriptional regulator
ACH33_RS16430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACH33_RS16540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACH33_RS16545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACH33_RS16545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACH33_RS16550	COG0736	holo-[acyl-carrier-protein] synthase activity
ACH33_RS16555	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACH33_RS16560	COG1294	oxidase, subunit
ACH33_RS16565	COG1360	Flagellar Motor Protein
ACH33_RS16575	COG0454	-acetyltransferase
ACH33_RS16585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACH33_RS16590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACH33_RS16595	COG0586	Pfam SNARE associated Golgi protein
ACH33_RS16600	COG1316	TRANSCRIPTIONal
ACH33_RS16615	COG0463	Glycosyl transferase, family 2
ACH33_RS16620	COG0785	Cytochrome C biogenesis protein
ACH33_RS16625	COG3279	Response regulator of the LytR AlgR family
ACH33_RS16630	COG4512	PFAM Accessory gene regulator B
ACH33_RS16645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACH33_RS16650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACH33_RS16655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACH33_RS16660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACH33_RS16665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ACH33_RS16665	COG2508	Transcriptional regulator
ACH33_RS16675	COG3829	transcription factor binding
ACH33_RS16680	COG1509	lysine 2,3-aminomutase activity
ACH33_RS16695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACH33_RS16710	COG2323	membrane
ACH33_RS16720	COG0071	Belongs to the small heat shock protein (HSP20) family
ACH33_RS16725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACH33_RS16730	COG0840	transmembrane signaling receptor activity
ACH33_RS16800	COG3335	DDE superfamily endonuclease
ACH33_RS16860	COG1876	peptidase activity
ACH33_RS16865	COG4824	toxin secretion phage lysis holin
ACH33_RS16910	COG1484	DNA-dependent DNA replication
ACH33_RS16950	COG1396	sequence-specific DNA binding
ACH33_RS16955	COG0735	belongs to the Fur family
ACH33_RS16960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACH33_RS16965	COG1121	(ABC) transporter
ACH33_RS16970	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACH33_RS16980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACH33_RS16985	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ACH33_RS17015	COG1595	DNA-templated transcription, initiation
ACH33_RS17025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACH33_RS17030	COG2205	protein histidine kinase activity
ACH33_RS17035	COG0745	RESPONSE REGULATOR receiver
ACH33_RS17045	COG3829	transcription factor binding
ACH33_RS17045	COG3290	protein histidine kinase activity
ACH33_RS17060	COG1012	belongs to the aldehyde dehydrogenase family
ACH33_RS17070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACH33_RS17095	COG0477	Major facilitator Superfamily
ACH33_RS17100	COG0531	amino acid
ACH33_RS17110	COG2427	Protein of unknown function (DUF1641)
ACH33_RS17115	COG3383	formate dehydrogenase (NAD+) activity
ACH33_RS17120	COG4948	Mandelate Racemase Muconate Lactonizing
ACH33_RS17135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACH33_RS17140	COG0367	asparagine synthase
ACH33_RS17250	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ACH33_RS17255	COG1024	Enoyl-CoA hydratase
ACH33_RS17260	COG1115	amino acid carrier protein
ACH33_RS17265	COG0288	reversible hydration of carbon dioxide
ACH33_RS17275	COG0450	alkyl hydroperoxide reductase
ACH33_RS17310	COG2205	protein histidine kinase activity
ACH33_RS17315	COG0745	RESPONSE REGULATOR receiver
ACH33_RS17335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACH33_RS17340	COG4856	YbbR-like protein
ACH33_RS17345	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ACH33_RS17350	COG5662	AntiSigma factor
ACH33_RS17355	COG1595	DNA-templated transcription, initiation
ACH33_RS17360	COG0010	Belongs to the arginase family
ACH33_RS17460	COG0726	polysaccharide deacetylase
ACH33_RS17465	COG2194	sulfuric ester hydrolase activity
ACH33_RS17475	COG0489	protein tyrosine kinase activity
ACH33_RS17480	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACH33_RS17490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACH33_RS17495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACH33_RS17500	COG0101	tRNA pseudouridine synthase activity
ACH33_RS17505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ACH33_RS17510	COG1122	ATPase activity
ACH33_RS17515	COG1122	ATPase activity
ACH33_RS17520	COG0203	ribosomal protein L17
ACH33_RS17525	COG0202	RNA polymerase activity
ACH33_RS17530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACH33_RS17535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACH33_RS17540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACH33_RS17545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACH33_RS17550	COG0024	Methionine aminopeptidase
ACH33_RS17555	COG0563	adenylate kinase activity
ACH33_RS17560	COG0201	protein transport
ACH33_RS17565	COG0200	Binds to the 23S rRNA
ACH33_RS17570	COG1841	ribosomal large subunit assembly
ACH33_RS17575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACH33_RS17580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACH33_RS17585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACH33_RS17590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACH33_RS17595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACH33_RS17600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACH33_RS17610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACH33_RS17615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACH33_RS17620	COG0255	Belongs to the universal ribosomal protein uL29 family
ACH33_RS17625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACH33_RS17630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACH33_RS17635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACH33_RS17640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACH33_RS17645	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACH33_RS17650	COG0089	rRNA binding
ACH33_RS17655	COG0088	Forms part of the polypeptide exit tunnel
ACH33_RS17660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACH33_RS17665	COG0051	transcription antitermination factor activity, RNA binding
ACH33_RS17685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACH33_RS17695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACH33_RS17700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACH33_RS17705	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACH33_RS17710	COG2271	Major facilitator Superfamily
ACH33_RS17715	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ACH33_RS17765	COG0531	amino acid
ACH33_RS17780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACH33_RS17785	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACH33_RS17790	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ACH33_RS17845	COG0704	Plays a role in the regulation of phosphate uptake
ACH33_RS17850	COG0772	Belongs to the SEDS family
ACH33_RS17855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACH33_RS17860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACH33_RS17865	COG0049	tRNA binding
ACH33_RS17870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACH33_RS17875	COG1358	cellular component organization or biogenesis
ACH33_RS17880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACH33_RS17885	COG0085	RNA polymerase activity
ACH33_RS17890	COG2813	Specifically methylates the guanine in position
ACH33_RS17895	COG0222	ribosome binding
ACH33_RS17900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACH33_RS17905	COG0081	regulation of translation
ACH33_RS17910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACH33_RS17915	COG0250	Participates in transcription elongation, termination and antitermination
ACH33_RS17920	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACH33_RS17925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACH33_RS17930	COG0840	transmembrane signaling receptor activity
ACH33_RS17940	COG3688	RNA-binding protein containing a PIN domain
ACH33_RS17945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACH33_RS17950	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ACH33_RS17955	COG0215	cysteine-tRNA ligase activity
ACH33_RS17960	COG1045	serine acetyltransferase
ACH33_RS17965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACH33_RS17975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACH33_RS17980	COG4956	integral membrane protein (PIN domain superfamily)
ACH33_RS17985	COG1329	Transcriptional regulator
ACH33_RS17990	COG1183	phosphatidylcholine synthase activity
ACH33_RS17995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ACH33_RS18000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACH33_RS18005	COG0542	response to heat
ACH33_RS18010	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ACH33_RS18015	COG3880	PFAM UvrB UvrC protein
ACH33_RS18025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACH33_RS18030	COG0581	inorganic phosphate transmembrane transporter activity
ACH33_RS18035	COG0573	inorganic phosphate transmembrane transporter activity
ACH33_RS18045	COG4948	Mandelate Racemase Muconate Lactonizing
ACH33_RS18055	COG1473	amidohydrolase
ACH33_RS18090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACH33_RS18095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACH33_RS18100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACH33_RS18105	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACH33_RS18110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACH33_RS18115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACH33_RS18120	COG0512	Glutamine amidotransferase of anthranilate synthase
ACH33_RS18125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACH33_RS18130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACH33_RS18135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACH33_RS18150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACH33_RS18155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACH33_RS18160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACH33_RS18170	COG0037	tRNA processing
ACH33_RS18180	COG2208	phosphoserine phosphatase activity
ACH33_RS18200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACH33_RS18205	COG3956	TIGRFAM MazG family protein
ACH33_RS18210	COG2244	polysaccharide biosynthetic process
ACH33_RS18220	COG2002	toxin-antitoxin pair type II binding
ACH33_RS18230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACH33_RS18240	COG0193	aminoacyl-tRNA hydrolase activity
ACH33_RS18245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACH33_RS18250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACH33_RS18255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACH33_RS18260	COG2088	sporulation resulting in formation of a cellular spore
ACH33_RS18265	COG0251	oxidation-reduction process
ACH33_RS18270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACH33_RS18275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACH33_RS18285	COG4466	Protein conserved in bacteria
ACH33_RS18295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACH33_RS18305	COG3584	3D domain protein
ACH33_RS18305	COG3583	domain protein
ACH33_RS18310	COG0084	hydrolase, TatD family'
ACH33_RS18315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACH33_RS18315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACH33_RS18320	COG2002	toxin-antitoxin pair type II binding
ACH33_RS18325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACH33_RS18330	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACH33_RS18335	COG4467	Involved in initiation control of chromosome replication
ACH33_RS18340	COG1774	PSP1 C-terminal conserved region
ACH33_RS18350	COG1728	Protein conserved in bacteria
ACH33_RS18355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACH33_RS18360	COG1982	Orn Lys Arg decarboxylase major