locus-tag	class	description
K3F53_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K3F53_RS00010	COG0592	DNA-directed DNA polymerase activity
K3F53_RS00015	COG2501	S4 domain
K3F53_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K3F53_RS00030	COG0187	DNA topoisomerase II activity
K3F53_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3F53_RS00060	COG0516	GMP reductase activity
K3F53_RS00060	COG0517	IMP dehydrogenase activity
K3F53_RS00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K3F53_RS00075	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS00105	COG0579	oxidoreductase
K3F53_RS00120	COG1476	TRANSCRIPTIONal
K3F53_RS00130	COG2315	Protein conserved in bacteria
K3F53_RS00150	COG0582	viral genome integration into host DNA
K3F53_RS00190	COG0310	cobalt ion transport
K3F53_RS00205	COG1122	ATPase activity
K3F53_RS00230	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K3F53_RS00260	COG1587	Uroporphyrinogen-III synthase
K3F53_RS00260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K3F53_RS00270	COG0776	regulation of translation
K3F53_RS00275	COG1842	Phage shock protein A
K3F53_RS00285	COG2112	serine threonine protein kinase
K3F53_RS00290	COG3290	protein histidine kinase activity
K3F53_RS00290	COG3829	transcription factor binding
K3F53_RS00295	COG1024	Enoyl-CoA hydratase
K3F53_RS00300	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3F53_RS00310	COG0596	Alpha beta hydrolase
K3F53_RS00315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K3F53_RS00320	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K3F53_RS00325	COG0590	tRNA wobble adenosine to inosine editing
K3F53_RS00335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K3F53_RS00340	COG1309	transcriptional regulator
K3F53_RS00355	COG1659	Linocin_M18 bacteriocin protein
K3F53_RS00375	COG3852	Histidine kinase
K3F53_RS00380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K3F53_RS00385	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K3F53_RS00390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K3F53_RS00440	COG1982	Orn Lys Arg decarboxylase major
K3F53_RS00445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K3F53_RS00450	COG1728	Protein conserved in bacteria
K3F53_RS00460	COG1774	PSP1 C-terminal conserved region
K3F53_RS00465	COG4467	Involved in initiation control of chromosome replication
K3F53_RS00470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K3F53_RS00475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K3F53_RS00480	COG2002	toxin-antitoxin pair type II binding
K3F53_RS00485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3F53_RS00485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3F53_RS00490	COG0084	hydrolase, TatD family'
K3F53_RS00495	COG3583	domain protein
K3F53_RS00495	COG3584	3D domain protein
K3F53_RS00505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K3F53_RS00515	COG4466	Protein conserved in bacteria
K3F53_RS00525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K3F53_RS00530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3F53_RS00535	COG0251	oxidation-reduction process
K3F53_RS00540	COG2088	sporulation resulting in formation of a cellular spore
K3F53_RS00545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3F53_RS00550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K3F53_RS00555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K3F53_RS00560	COG0193	aminoacyl-tRNA hydrolase activity
K3F53_RS00570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K3F53_RS00580	COG2002	toxin-antitoxin pair type II binding
K3F53_RS00585	COG2244	polysaccharide biosynthetic process
K3F53_RS00590	COG3956	TIGRFAM MazG family protein
K3F53_RS00595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K3F53_RS00615	COG2208	phosphoserine phosphatase activity
K3F53_RS00625	COG0037	tRNA processing
K3F53_RS00635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3F53_RS00640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K3F53_RS00645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K3F53_RS00660	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K3F53_RS00665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K3F53_RS00670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K3F53_RS00675	COG0512	Glutamine amidotransferase of anthranilate synthase
K3F53_RS00680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3F53_RS00685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K3F53_RS00690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K3F53_RS00695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K3F53_RS00700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K3F53_RS00705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K3F53_RS00710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K3F53_RS00735	COG1473	amidohydrolase
K3F53_RS00745	COG4948	Mandelate Racemase Muconate Lactonizing
K3F53_RS00755	COG0573	inorganic phosphate transmembrane transporter activity
K3F53_RS00760	COG0581	inorganic phosphate transmembrane transporter activity
K3F53_RS00765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3F53_RS00775	COG3880	PFAM UvrB UvrC protein
K3F53_RS00780	COG3869	Catalyzes the specific phosphorylation of arginine residues in
K3F53_RS00785	COG0542	response to heat
K3F53_RS00790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K3F53_RS00795	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K3F53_RS00800	COG1183	phosphatidylcholine synthase activity
K3F53_RS00805	COG1329	Transcriptional regulator
K3F53_RS00810	COG4956	integral membrane protein (PIN domain superfamily)
K3F53_RS00815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K3F53_RS00825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K3F53_RS00830	COG1045	serine acetyltransferase
K3F53_RS00835	COG0215	cysteine-tRNA ligase activity
K3F53_RS00840	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K3F53_RS00845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3F53_RS00850	COG3688	RNA-binding protein containing a PIN domain
K3F53_RS00860	COG0840	transmembrane signaling receptor activity
K3F53_RS00865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K3F53_RS00870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K3F53_RS00875	COG0250	Participates in transcription elongation, termination and antitermination
K3F53_RS00880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K3F53_RS00885	COG0081	regulation of translation
K3F53_RS00890	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K3F53_RS00895	COG0222	ribosome binding
K3F53_RS00900	COG2813	Specifically methylates the guanine in position
K3F53_RS00905	COG0085	RNA polymerase activity
K3F53_RS00910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K3F53_RS00915	COG1358	cellular component organization or biogenesis
K3F53_RS00920	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K3F53_RS00925	COG0049	tRNA binding
K3F53_RS00930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K3F53_RS00935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K3F53_RS00940	COG0772	Belongs to the SEDS family
K3F53_RS00945	COG0704	Plays a role in the regulation of phosphate uptake
K3F53_RS01005	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K3F53_RS01010	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3F53_RS01015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3F53_RS01020	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K3F53_RS01025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K3F53_RS01030	COG0531	amino acid
K3F53_RS01080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K3F53_RS01085	COG2271	Major facilitator Superfamily
K3F53_RS01090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K3F53_RS01095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K3F53_RS01100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K3F53_RS01110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3F53_RS01140	COG0051	transcription antitermination factor activity, RNA binding
K3F53_RS01145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K3F53_RS01150	COG0088	Forms part of the polypeptide exit tunnel
K3F53_RS01155	COG0089	rRNA binding
K3F53_RS01160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K3F53_RS01165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K3F53_RS01170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K3F53_RS01175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K3F53_RS01180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K3F53_RS01185	COG0255	Belongs to the universal ribosomal protein uL29 family
K3F53_RS01190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K3F53_RS01195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K3F53_RS01205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K3F53_RS01210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3F53_RS01215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K3F53_RS01220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K3F53_RS01225	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K3F53_RS01230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K3F53_RS01235	COG1841	ribosomal large subunit assembly
K3F53_RS01240	COG0200	Binds to the 23S rRNA
K3F53_RS01245	COG0201	protein transport
K3F53_RS01250	COG0563	adenylate kinase activity
K3F53_RS01255	COG0024	Methionine aminopeptidase
K3F53_RS01260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K3F53_RS01265	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K3F53_RS01270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K3F53_RS01275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K3F53_RS01280	COG0202	RNA polymerase activity
K3F53_RS01285	COG0203	ribosomal protein L17
K3F53_RS01290	COG1122	ATPase activity
K3F53_RS01295	COG1122	ATPase activity
K3F53_RS01300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3F53_RS01305	COG0101	tRNA pseudouridine synthase activity
K3F53_RS01310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K3F53_RS01315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K3F53_RS01325	COG0860	N-Acetylmuramoyl-L-alanine amidase
K3F53_RS01330	COG0489	protein tyrosine kinase activity
K3F53_RS01340	COG2194	sulfuric ester hydrolase activity
K3F53_RS01345	COG0726	polysaccharide deacetylase
K3F53_RS01445	COG0010	Belongs to the arginase family
K3F53_RS01450	COG1595	DNA-templated transcription, initiation
K3F53_RS01455	COG5662	AntiSigma factor
K3F53_RS01460	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K3F53_RS01465	COG4856	YbbR-like protein
K3F53_RS01470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3F53_RS01490	COG0745	RESPONSE REGULATOR receiver
K3F53_RS01495	COG2205	protein histidine kinase activity
K3F53_RS01535	COG0450	alkyl hydroperoxide reductase
K3F53_RS01555	COG0288	reversible hydration of carbon dioxide
K3F53_RS01560	COG1115	amino acid carrier protein
K3F53_RS01565	COG1024	Enoyl-CoA hydratase
K3F53_RS01570	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
K3F53_RS01680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K3F53_RS01680	COG0189	ligase activity
K3F53_RS01690	COG0367	asparagine synthase
K3F53_RS01695	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K3F53_RS01710	COG4948	Mandelate Racemase Muconate Lactonizing
K3F53_RS01715	COG3383	formate dehydrogenase (NAD+) activity
K3F53_RS01720	COG2427	Protein of unknown function (DUF1641)
K3F53_RS01730	COG0531	amino acid
K3F53_RS01740	COG0477	Major facilitator Superfamily
K3F53_RS01765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K3F53_RS01770	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS01785	COG3290	protein histidine kinase activity
K3F53_RS01785	COG3829	transcription factor binding
K3F53_RS01795	COG0745	RESPONSE REGULATOR receiver
K3F53_RS01800	COG2205	protein histidine kinase activity
K3F53_RS01805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3F53_RS01815	COG1595	DNA-templated transcription, initiation
K3F53_RS01845	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K3F53_RS01850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K3F53_RS01855	COG0803	Belongs to the bacterial solute-binding protein 9 family
K3F53_RS01860	COG1121	(ABC) transporter
K3F53_RS01865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K3F53_RS01870	COG0735	belongs to the Fur family
K3F53_RS01875	COG1396	sequence-specific DNA binding
K3F53_RS01920	COG1484	DNA-dependent DNA replication
K3F53_RS01960	COG4824	toxin secretion phage lysis holin
K3F53_RS02020	COG3335	DDE superfamily endonuclease
K3F53_RS02105	COG0840	transmembrane signaling receptor activity
K3F53_RS02110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K3F53_RS02115	COG0071	Belongs to the small heat shock protein (HSP20) family
K3F53_RS02130	COG2323	membrane
K3F53_RS02145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3F53_RS02160	COG1509	lysine 2,3-aminomutase activity
K3F53_RS02165	COG3829	transcription factor binding
K3F53_RS02175	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K3F53_RS02175	COG2508	Transcriptional regulator
K3F53_RS02180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3F53_RS02185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K3F53_RS02190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K3F53_RS02195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K3F53_RS02210	COG4512	PFAM Accessory gene regulator B
K3F53_RS02220	COG3279	Response regulator of the LytR AlgR family
K3F53_RS02225	COG0785	Cytochrome C biogenesis protein
K3F53_RS02230	COG0463	Glycosyl transferase, family 2
K3F53_RS02245	COG1316	TRANSCRIPTIONal
K3F53_RS02250	COG0586	Pfam SNARE associated Golgi protein
K3F53_RS02255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3F53_RS02260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K3F53_RS02270	COG0454	-acetyltransferase
K3F53_RS02280	COG1360	Flagellar Motor Protein
K3F53_RS02285	COG1294	oxidase, subunit
K3F53_RS02290	COG0860	N-Acetylmuramoyl-L-alanine amidase
K3F53_RS02295	COG0736	holo-[acyl-carrier-protein] synthase activity
K3F53_RS02300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K3F53_RS02300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K3F53_RS02305	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K3F53_RS02420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K3F53_RS02425	COG0864	Transcriptional regulator
K3F53_RS02430	COG2337	Toxic component of a toxin-antitoxin (TA) module
K3F53_RS02435	COG2183	response to ionizing radiation
K3F53_RS02450	COG3091	SprT-like family
K3F53_RS02455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K3F53_RS02460	COG0802	atpase or kinase
K3F53_RS02465	COG1214	PFAM Peptidase M22, glycoprotease
K3F53_RS02470	COG0456	acetyltransferase
K3F53_RS02485	COG0488	(ABC) transporter
K3F53_RS02490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K3F53_RS02495	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3F53_RS02500	COG0805	protein transport
K3F53_RS02505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K3F53_RS02510	COG0459	protein refolding
K3F53_RS02515	COG0519	Catalyzes the synthesis of GMP from XMP
K3F53_RS02515	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K3F53_RS02520	COG2252	PERMEase
K3F53_RS02525	COG3437	response regulator, receiver
K3F53_RS02540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K3F53_RS02545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K3F53_RS02550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K3F53_RS02555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K3F53_RS02560	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3F53_RS02565	COG0047	phosphoribosylformylglycinamidine synthase activity
K3F53_RS02570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K3F53_RS02575	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K3F53_RS02580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K3F53_RS02585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K3F53_RS02595	COG0151	Belongs to the GarS family
K3F53_RS02620	COG0411	ABC transporter
K3F53_RS02630	COG1470	cell adhesion involved in biofilm formation
K3F53_RS02635	COG0840	transmembrane signaling receptor activity
K3F53_RS02640	COG0675	Transposase, IS605 OrfB family
K3F53_RS02645	COG4496	protein, YerC YecD
K3F53_RS02665	COG1131	(ABC) transporter
K3F53_RS02680	COG0210	DNA helicase
K3F53_RS02685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3F53_RS02700	COG0840	transmembrane signaling receptor activity
K3F53_RS02705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3F53_RS02710	COG0154	amidase activity
K3F53_RS02715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K3F53_RS02725	COG0582	viral genome integration into host DNA
K3F53_RS02730	COG3706	GGDEF domain
K3F53_RS02740	COG2186	Transcriptional regulator
K3F53_RS02745	COG0277	FAD linked oxidase domain protein
K3F53_RS02750	COG0247	lactate metabolic process
K3F53_RS02755	COG1396	sequence-specific DNA binding
K3F53_RS02760	COG3852	Histidine kinase
K3F53_RS02765	COG1597	lipid kinase activity
K3F53_RS02775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K3F53_RS02780	COG1131	(ABC) transporter
K3F53_RS02825	COG5002	protein histidine kinase activity
K3F53_RS02845	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K3F53_RS02880	COG3104	oligopeptide transport
K3F53_RS02910	COG1203	CRISPR-associated helicase, Cas3
K3F53_RS02925	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K3F53_RS02960	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K3F53_RS02965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3F53_RS02975	COG0531	amino acid
K3F53_RS02980	COG1823	symporter activity
K3F53_RS03005	COG2259	Doxx family
K3F53_RS03015	COG0535	radical SAM domain protein
K3F53_RS03020	COG1132	(ABC) transporter
K3F53_RS03030	COG1131	(ABC) transporter
K3F53_RS03040	COG2323	membrane
K3F53_RS03050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3F53_RS03060	COG0598	Magnesium transport protein CorA
K3F53_RS03065	COG0733	neurotransmitter:sodium symporter activity
K3F53_RS03075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3F53_RS03080	COG0733	neurotransmitter:sodium symporter activity
K3F53_RS03085	COG4840	Belongs to the UPF0435 family
K3F53_RS03090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K3F53_RS03120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K3F53_RS03165	COG1280	lysine exporter protein (LysE YggA)
K3F53_RS03170	COG0827	DNA restriction-modification system
K3F53_RS03175	COG0827	DNA restriction-modification system
K3F53_RS03180	COG0500	methyltransferase
K3F53_RS03180	COG3615	Tellurite resistance protein tehB
K3F53_RS03185	COG2226	methyltransferase
K3F53_RS03195	COG4191	Histidine kinase
K3F53_RS03210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3F53_RS03215	COG1960	acyl-CoA dehydrogenase activity
K3F53_RS03220	COG1113	amino acid transport
K3F53_RS03225	COG1183	phosphatidylcholine synthase activity
K3F53_RS03240	COG1929	Belongs to the glycerate kinase type-1 family
K3F53_RS03255	COG0697	spore germination
K3F53_RS03275	COG3829	transcription factor binding
K3F53_RS03275	COG3290	protein histidine kinase activity
K3F53_RS03280	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS03285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3F53_RS03295	COG1136	(ABC) transporter
K3F53_RS03300	COG0577	efflux transmembrane transporter activity
K3F53_RS03310	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K3F53_RS03320	COG0306	phosphate transporter
K3F53_RS03325	COG0175	sulfate reduction
K3F53_RS03330	COG2046	Belongs to the sulfate adenylyltransferase family
K3F53_RS03335	COG0529	Catalyzes the synthesis of activated sulfate
K3F53_RS03345	COG0534	Mate efflux family protein
K3F53_RS03350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K3F53_RS03355	COG2340	Cysteine-rich secretory protein family
K3F53_RS03365	COG1988	membrane-bound metal-dependent
K3F53_RS03380	COG0277	FAD linked oxidase domain protein
K3F53_RS03385	COG0247	lactate metabolic process
K3F53_RS03390	COG2814	Major facilitator Superfamily
K3F53_RS03395	COG0670	Belongs to the BI1 family
K3F53_RS03410	COG0456	acetyltransferase
K3F53_RS03415	COG3557	Belongs to the UPF0374 family
K3F53_RS03420	COG1132	(ABC) transporter
K3F53_RS03425	COG2249	NAD(P)H dehydrogenase (quinone) activity
K3F53_RS03430	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K3F53_RS03435	COG0235	Class ii aldolase
K3F53_RS03440	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K3F53_RS03445	COG1850	ribulose-bisphosphate carboxylase activity
K3F53_RS03455	COG0067	glutamate synthase
K3F53_RS03455	COG0069	glutamate synthase activity
K3F53_RS03455	COG0070	glutamate synthase
K3F53_RS03460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K3F53_RS03465	COG4555	ABC transporter
K3F53_RS03500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K3F53_RS03505	COG2226	methyltransferase
K3F53_RS03515	COG2096	Adenosyltransferase
K3F53_RS03550	COG0735	belongs to the Fur family
K3F53_RS03660	COG1573	uracil-dna glycosylase
K3F53_RS03670	COG1573	uracil-dna glycosylase
K3F53_RS03675	COG2233	PERMEase
K3F53_RS03685	COG0328	RNA-DNA hybrid ribonuclease activity
K3F53_RS03695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K3F53_RS03705	COG0616	signal peptide processing
K3F53_RS03710	COG1714	RDD family
K3F53_RS03725	COG1464	Belongs to the NlpA lipoprotein family
K3F53_RS03735	COG2766	serine protein kinase
K3F53_RS03740	COG2718	Belongs to the UPF0229 family
K3F53_RS03915	COG4824	toxin secretion phage lysis holin
K3F53_RS03930	COG3335	DDE superfamily endonuclease
K3F53_RS03955	COG2719	SpoVR family
K3F53_RS03965	COG3384	dioxygenase
K3F53_RS03985	COG1741	Belongs to the pirin family
K3F53_RS03995	COG1937	Protein conserved in bacteria
K3F53_RS04005	COG1683	Conserved Protein
K3F53_RS04010	COG0436	Aminotransferase
K3F53_RS04015	COG1757	Na H antiporter
K3F53_RS04035	COG0189	ligase activity
K3F53_RS04040	COG0189	ligase activity
K3F53_RS04045	COG0189	ligase activity
K3F53_RS04050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K3F53_RS04060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K3F53_RS04070	COG4109	DRTGG domain
K3F53_RS04095	COG0587	DNA-directed DNA polymerase activity
K3F53_RS04100	COG0281	malic enzyme
K3F53_RS04105	COG2186	Transcriptional regulator
K3F53_RS04115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K3F53_RS04120	COG0825	malonyl-CoA metabolic process
K3F53_RS04130	COG0824	Thioesterase
K3F53_RS04135	COG3030	protein affecting phage T7 exclusion by the F plasmid
K3F53_RS04140	COG0628	permease
K3F53_RS04145	COG0372	Belongs to the citrate synthase family
K3F53_RS04150	COG0538	isocitrate dehydrogenase activity
K3F53_RS04155	COG0039	L-malate dehydrogenase activity
K3F53_RS04180	COG0745	RESPONSE REGULATOR receiver
K3F53_RS04185	COG5002	protein histidine kinase activity
K3F53_RS04195	COG0330	HflC and HflK could
K3F53_RS04200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3F53_RS04200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3F53_RS04205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K3F53_RS04210	COG1971	Probably functions as a manganese efflux pump
K3F53_RS04215	COG0237	dephospho-CoA kinase activity
K3F53_RS04220	COG0739	heme binding
K3F53_RS04220	COG0741	lytic transglycosylase activity
K3F53_RS04220	COG1196	nuclear chromosome segregation
K3F53_RS04225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K3F53_RS04230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K3F53_RS04235	COG3611	Membrane attachment protein
K3F53_RS04240	COG1484	DNA-dependent DNA replication
K3F53_RS04245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K3F53_RS04255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K3F53_RS04260	COG0840	transmembrane signaling receptor activity
K3F53_RS04265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K3F53_RS04275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K3F53_RS04285	COG1832	CoA-binding protein
K3F53_RS04295	COG3335	DDE superfamily endonuclease
K3F53_RS04325	COG0702	epimerase
K3F53_RS04330	COG0688	phosphatidylethanolamine metabolic process
K3F53_RS04355	COG1609	Transcriptional regulator
K3F53_RS04360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K3F53_RS04365	COG1869	D-ribose catabolic process
K3F53_RS04370	COG1129	ABC transporter
K3F53_RS04375	COG1172	Belongs to the binding-protein-dependent transport system permease family
K3F53_RS04380	COG1879	ABC-type sugar transport system periplasmic component
K3F53_RS04420	COG2011	ABC-type metal ion transport system permease component
K3F53_RS04425	COG1464	Belongs to the NlpA lipoprotein family
K3F53_RS04435	COG2362	D-Aminopeptidase
K3F53_RS04445	COG0179	Fumarylacetoacetate (FAA) hydrolase
K3F53_RS04450	COG0371	Dehydrogenase
K3F53_RS04490	COG3093	addiction module antidote protein HigA
K3F53_RS04515	COG1139	Iron-sulfur cluster binding protein
K3F53_RS04520	COG1556	Lactate utilization protein
K3F53_RS04550	COG2267	carboxylic ester hydrolase activity
K3F53_RS04555	COG1316	TRANSCRIPTIONal
K3F53_RS04560	COG1217	gtp-binding protein TYPA
K3F53_RS04565	COG2707	UPF0756 membrane protein
K3F53_RS04570	COG1242	4 iron, 4 sulfur cluster binding
K3F53_RS04585	COG1408	metallophosphoesterase
K3F53_RS04595	COG2814	Major facilitator Superfamily
K3F53_RS04610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3F53_RS04615	COG1924	4 iron, 4 sulfur cluster binding
K3F53_RS04625	COG2022	thiamine diphosphate biosynthetic process
K3F53_RS04630	COG2104	thiamine diphosphate biosynthetic process
K3F53_RS04635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3F53_RS04640	COG0352	thiamine-phosphate diphosphorylase activity
K3F53_RS04650	COG0861	Integral membrane protein TerC family
K3F53_RS04665	COG2226	methyltransferase
K3F53_RS04670	COG0483	inositol monophosphate 1-phosphatase activity
K3F53_RS04675	COG0720	synthase
K3F53_RS04680	COG0602	queuosine metabolic process
K3F53_RS04685	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3F53_RS04690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K3F53_RS04700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3F53_RS04710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3F53_RS04710	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K3F53_RS04715	COG1187	pseudouridine synthase activity
K3F53_RS04725	COG4758	membrane
K3F53_RS04730	COG4585	Histidine kinase
K3F53_RS04735	COG2197	response regulator
K3F53_RS04740	COG1376	ErfK ybiS ycfS ynhG family protein
K3F53_RS04745	COG0129	dihydroxy-acid dehydratase activity
K3F53_RS04750	COG1297	OPT oligopeptide transporter protein
K3F53_RS04775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K3F53_RS04785	COG0697	spore germination
K3F53_RS04790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K3F53_RS04795	COG0315	cyclic pyranopterin monophosphate synthase activity
K3F53_RS04805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3F53_RS04815	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS04845	COG0411	ABC transporter
K3F53_RS04850	COG0410	ABC transporter
K3F53_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS04870	COG1686	Belongs to the peptidase S11 family
K3F53_RS04965	COG0492	ferredoxin-NADP+ reductase activity
K3F53_RS04975	COG3331	DNA recombination
K3F53_RS04980	COG0778	Nitroreductase
K3F53_RS04985	COG3546	catalase activity
K3F53_RS05015	COG0517	IMP dehydrogenase activity
K3F53_RS05025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K3F53_RS05030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3F53_RS05050	COG0473	3-isopropylmalate dehydrogenase activity
K3F53_RS05065	COG3118	belongs to the thioredoxin family
K3F53_RS05075	COG1605	Chorismate mutase
K3F53_RS05075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K3F53_RS05090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K3F53_RS05095	COG0123	including yeast histone deacetylase and acetoin utilization protein
K3F53_RS05100	COG0454	-acetyltransferase
K3F53_RS05105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3F53_RS05110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3F53_RS05115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K3F53_RS05120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K3F53_RS05130	COG0133	tryptophan synthase activity
K3F53_RS05140	COG2199	diguanylate cyclase activity
K3F53_RS05140	COG2203	Gaf domain
K3F53_RS05145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3F53_RS05155	COG1309	transcriptional regulator
K3F53_RS05160	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K3F53_RS05165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3F53_RS05170	COG3162	membrane
K3F53_RS05175	COG2081	HI0933 family
K3F53_RS05190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K3F53_RS05195	COG0644	oxidoreductase
K3F53_RS05215	COG1595	DNA-templated transcription, initiation
K3F53_RS05220	COG0531	amino acid
K3F53_RS05225	COG0386	Belongs to the glutathione peroxidase family
K3F53_RS05235	COG2155	Conserved Protein
K3F53_RS05240	COG0300	oxidoreductase activity
K3F53_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS05250	COG1473	amidohydrolase
K3F53_RS05275	COG1104	cysteine desulfurase activity
K3F53_RS05280	COG0301	tRNA thio-modification
K3F53_RS05285	COG3243	poly(R)-hydroxyalkanoic acid synthase
K3F53_RS05310	COG2030	dehydratase
K3F53_RS05320	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K3F53_RS05330	COG2259	Doxx family
K3F53_RS05340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K3F53_RS05350	COG0004	ammonium transporteR
K3F53_RS05365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K3F53_RS05370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3F53_RS05405	COG0302	gtp cyclohydrolase
K3F53_RS05410	COG0788	formyltetrahydrofolate deformylase activity
K3F53_RS05425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K3F53_RS05430	COG0861	Integral membrane protein TerC family
K3F53_RS05440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3F53_RS05445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K3F53_RS05450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K3F53_RS05465	COG3874	Sporulation protein YtfJ
K3F53_RS05470	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K3F53_RS05475	COG0564	pseudouridine synthase activity
K3F53_RS05485	COG4120	Belongs to the binding-protein-dependent transport system permease family
K3F53_RS05490	COG1122	ATPase activity
K3F53_RS05500	COG1902	pentaerythritol trinitrate reductase activity
K3F53_RS05510	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K3F53_RS05510	COG0165	Argininosuccinate lyase
K3F53_RS05550	COG0464	growth
K3F53_RS05555	COG3829	transcription factor binding
K3F53_RS05555	COG3290	protein histidine kinase activity
K3F53_RS05560	COG2610	gluconate transmembrane transporter activity
K3F53_RS05565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K3F53_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS05580	COG0477	Major facilitator Superfamily
K3F53_RS05590	COG0840	transmembrane signaling receptor activity
K3F53_RS05600	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K3F53_RS05605	COG0205	6-phosphofructokinase activity
K3F53_RS05610	COG0166	Belongs to the GPI family
K3F53_RS05615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K3F53_RS05620	COG1396	sequence-specific DNA binding
K3F53_RS05625	COG1476	TRANSCRIPTIONal
K3F53_RS05635	COG2423	ornithine cyclodeaminase activity
K3F53_RS05645	COG1131	(ABC) transporter
K3F53_RS05650	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K3F53_RS05685	COG1309	transcriptional regulator
K3F53_RS05690	COG0644	oxidoreductase
K3F53_RS05690	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
K3F53_RS05695	COG2204	response regulator
K3F53_RS05700	COG1744	ABC transporter substrate-binding protein PnrA-like
K3F53_RS05705	COG2205	protein histidine kinase activity
K3F53_RS05705	COG0784	Response regulator, receiver
K3F53_RS05705	COG5002	protein histidine kinase activity
K3F53_RS05715	COG2202	Pas domain
K3F53_RS05715	COG2205	protein histidine kinase activity
K3F53_RS05720	COG2154	pterin-4-alpha-carbinolamine dehydratase
K3F53_RS05730	COG0318	PFAM AMP-dependent synthetase and ligase
K3F53_RS05735	COG0741	lytic transglycosylase activity
K3F53_RS05745	COG2346	COG2346, Truncated hemoglobins
K3F53_RS05760	COG0306	phosphate transporter
K3F53_RS05765	COG1392	Phosphate transport regulator
K3F53_RS05800	COG1024	Enoyl-CoA hydratase
K3F53_RS05815	COG4848	Belongs to the UPF0354 family
K3F53_RS05820	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS05825	COG0681	Belongs to the peptidase S26 family
K3F53_RS05835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K3F53_RS05850	COG2738	Putative neutral zinc metallopeptidase
K3F53_RS05855	COG1253	flavin adenine dinucleotide binding
K3F53_RS05870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K3F53_RS05880	COG0463	Glycosyl transferase, family 2
K3F53_RS05895	COG3829	transcription factor binding
K3F53_RS05895	COG3290	protein histidine kinase activity
K3F53_RS05900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3F53_RS05905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3F53_RS05910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3F53_RS05915	COG0022	dehydrogenase e1 component
K3F53_RS05920	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3F53_RS05925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3F53_RS05925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3F53_RS05930	COG0346	lactoylglutathione lyase activity
K3F53_RS05935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3F53_RS05940	COG2195	Cleaves the N-terminal amino acid of tripeptides
K3F53_RS05950	COG0494	nUDIX hydrolase
K3F53_RS05955	COG1379	DNA repair
K3F53_RS05960	COG1300	Membrane
K3F53_RS05965	COG0735	belongs to the Fur family
K3F53_RS05970	COG0768	penicillin binding
K3F53_RS05980	COG4974	Belongs to the 'phage' integrase family
K3F53_RS05985	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K3F53_RS05995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K3F53_RS06000	COG1522	sequence-specific DNA binding
K3F53_RS06005	COG4166	transmembrane transport
K3F53_RS06010	COG0601	transmembrane transport
K3F53_RS06015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K3F53_RS06020	COG0444	Belongs to the ABC transporter superfamily
K3F53_RS06025	COG4608	Belongs to the ABC transporter superfamily
K3F53_RS06030	COG1686	Belongs to the peptidase S11 family
K3F53_RS06040	COG2172	sigma factor antagonist activity
K3F53_RS06065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3F53_RS06080	COG0019	diaminopimelate decarboxylase activity
K3F53_RS06085	COG0537	adenosine 5'-monophosphoramidase activity
K3F53_RS06095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K3F53_RS06100	COG1113	amino acid transport
K3F53_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS06120	COG0579	oxidoreductase
K3F53_RS06125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K3F53_RS06130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3F53_RS06130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K3F53_RS06140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K3F53_RS06140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K3F53_RS06145	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K3F53_RS06150	COG1994	Peptidase M50
K3F53_RS06155	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K3F53_RS06160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K3F53_RS06165	COG1686	Belongs to the peptidase S11 family
K3F53_RS06170	COG2715	membrane protein required for spore maturation
K3F53_RS06175	COG0700	Nucleoside recognition
K3F53_RS06180	COG2190	(PTS) system
K3F53_RS06180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K3F53_RS06180	COG1263	PTS System
K3F53_RS06190	COG0363	glucosamine-6-phosphate deaminase activity
K3F53_RS06200	COG2190	(PTS) system
K3F53_RS06205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3F53_RS06210	COG1187	pseudouridine synthase activity
K3F53_RS06220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3F53_RS06225	COG1333	cytochrome c biogenesis protein
K3F53_RS06230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3F53_RS06240	COG0745	RESPONSE REGULATOR receiver
K3F53_RS06245	COG5002	protein histidine kinase activity
K3F53_RS06255	COG0824	Thioesterase
K3F53_RS06260	COG0745	RESPONSE REGULATOR receiver
K3F53_RS06265	COG5002	protein histidine kinase activity
K3F53_RS06270	COG2050	protein possibly involved in aromatic compounds catabolism
K3F53_RS06275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K3F53_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS06290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K3F53_RS06310	COG0598	Magnesium transport protein CorA
K3F53_RS06315	COG1141	Ferredoxin
K3F53_RS06320	COG4955	Helix-turn-helix domain
K3F53_RS06325	COG0514	ATP-dependent DNA helicase (RecQ)
K3F53_RS06345	COG0492	ferredoxin-NADP+ reductase activity
K3F53_RS06350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K3F53_RS06355	COG2357	RelA SpoT domain protein
K3F53_RS06365	COG4862	establishment of competence for transformation
K3F53_RS06370	COG1263	PTS System
K3F53_RS06370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K3F53_RS06370	COG2190	(PTS) system
K3F53_RS06380	COG0166	Belongs to the GPI family
K3F53_RS06385	COG3711	transcriptional antiterminator
K3F53_RS06390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3F53_RS06395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3F53_RS06400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3F53_RS06405	COG0492	ferredoxin-NADP+ reductase activity
K3F53_RS06410	COG2339	peptidase activity
K3F53_RS06420	COG2959	enzyme of heme biosynthesis
K3F53_RS06430	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K3F53_RS06440	COG0539	negative regulation of cytoplasmic translation
K3F53_RS06465	COG1160	GTP binding
K3F53_RS06470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K3F53_RS06510	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K3F53_RS06515	COG0776	regulation of translation
K3F53_RS06525	COG0142	geranyltranstransferase activity
K3F53_RS06530	COG2226	methyltransferase
K3F53_RS06535	COG0109	protoheme IX farnesyltransferase activity
K3F53_RS06540	COG0163	prenyltransferase activity
K3F53_RS06555	COG0105	UTP biosynthetic process
K3F53_RS06560	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K3F53_RS06565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K3F53_RS06570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K3F53_RS06575	COG4401	Chorismate mutase type I
K3F53_RS06585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K3F53_RS06590	COG0134	indole-3-glycerol-phosphate synthase activity
K3F53_RS06595	COG0135	phosphoribosylanthranilate isomerase activity
K3F53_RS06600	COG0133	tryptophan synthase activity
K3F53_RS06605	COG0159	tryptophan synthase activity
K3F53_RS06610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3F53_RS06615	COG0287	Prephenate dehydrogenase
K3F53_RS06620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K3F53_RS06635	COG1595	DNA-templated transcription, initiation
K3F53_RS06690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K3F53_RS06695	COG1694	Mazg nucleotide pyrophosphohydrolase
K3F53_RS06705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K3F53_RS06710	COG1803	Methylglyoxal synthase
K3F53_RS06715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K3F53_RS06720	COG0438	transferase activity, transferring glycosyl groups
K3F53_RS06725	COG0617	tRNA 3'-terminal CCA addition
K3F53_RS06730	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K3F53_RS06730	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K3F53_RS06735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K3F53_RS06740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K3F53_RS06745	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K3F53_RS06755	COG1199	ATP-dependent helicase activity
K3F53_RS06755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K3F53_RS06760	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K3F53_RS06765	COG0402	S-adenosylhomocysteine deaminase activity
K3F53_RS06780	COG0675	Transposase, IS605 OrfB family
K3F53_RS06790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K3F53_RS06795	COG0436	Aminotransferase
K3F53_RS06805	COG3935	DnaD domain protein
K3F53_RS06820	COG0574	Belongs to the PEP-utilizing enzyme family
K3F53_RS06820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K3F53_RS06830	COG1132	(ABC) transporter
K3F53_RS06835	COG0515	serine threonine protein kinase
K3F53_RS06850	COG0612	Peptidase, M16
K3F53_RS06855	COG0612	Peptidase, M16
K3F53_RS06860	COG0300	oxidoreductase activity
K3F53_RS06875	COG1426	Protein conserved in bacteria
K3F53_RS06880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3F53_RS06885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K3F53_RS06890	COG1058	Belongs to the CinA family
K3F53_RS06890	COG1546	Belongs to the CinA family
K3F53_RS06895	COG0513	Belongs to the DEAD box helicase family
K3F53_RS06900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3F53_RS06905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K3F53_RS06915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K3F53_RS06920	COG2137	regulation of response to DNA damage stimulus
K3F53_RS06925	COG1418	mRNA catabolic process
K3F53_RS06930	COG1692	metallophosphoesterase
K3F53_RS06935	COG2359	stage V sporulation protein S
K3F53_RS06940	COG0674	pyruvate-flavodoxin oxidoreductase activity
K3F53_RS06940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K3F53_RS06945	COG1013	pyruvate-flavodoxin oxidoreductase activity
K3F53_RS06950	COG1234	tRNA 3'-trailer cleavage
K3F53_RS06955	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K3F53_RS06970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3F53_RS06975	COG4550	Control of competence regulator ComK, YlbF/YmcA
K3F53_RS06985	COG1131	(ABC) transporter
K3F53_RS07010	COG0515	serine threonine protein kinase
K3F53_RS07010	COG3266	domain, Protein
K3F53_RS07025	COG0484	heat shock protein binding
K3F53_RS07190	COG2801	Transposase and inactivated derivatives
K3F53_RS07200	COG2368	4-hydroxyphenylacetate
K3F53_RS07215	COG0251	oxidation-reduction process
K3F53_RS07225	COG3971	2-oxopent-4-enoate hydratase activity
K3F53_RS07260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K3F53_RS07265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K3F53_RS07310	COG0531	amino acid
K3F53_RS07355	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3F53_RS07360	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K3F53_RS07375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3F53_RS07390	COG0473	3-isopropylmalate dehydrogenase activity
K3F53_RS07390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K3F53_RS07415	COG2267	carboxylic ester hydrolase activity
K3F53_RS07465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K3F53_RS07470	COG1151	hydroxylamine reductase activity
K3F53_RS07510	COG1063	alcohol dehydrogenase
K3F53_RS07520	COG0109	protoheme IX farnesyltransferase activity
K3F53_RS07530	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
K3F53_RS07535	COG2091	lysine biosynthetic process via aminoadipic acid
K3F53_RS07585	COG2217	Heavy metal translocating P-type atpase
K3F53_RS07590	COG2132	Multicopper oxidase
K3F53_RS07600	COG0745	RESPONSE REGULATOR receiver
K3F53_RS07605	COG5002	protein histidine kinase activity
K3F53_RS07615	COG1404	Belongs to the peptidase S8 family
K3F53_RS07620	COG0531	amino acid
K3F53_RS07625	COG3938	Belongs to the proline racemase family
K3F53_RS07630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K3F53_RS07635	COG3290	protein histidine kinase activity
K3F53_RS07635	COG3829	transcription factor binding
K3F53_RS07655	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS07660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3F53_RS07685	COG0602	queuosine metabolic process
K3F53_RS07690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K3F53_RS07715	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3F53_RS07725	COG0189	ligase activity
K3F53_RS07725	COG0569	domain protein
K3F53_RS07745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3F53_RS07760	COG0739	heme binding
K3F53_RS07795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3F53_RS07800	COG1408	metallophosphoesterase
K3F53_RS07805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K3F53_RS07815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS07820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS07825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K3F53_RS07835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K3F53_RS07840	COG1686	Belongs to the peptidase S11 family
K3F53_RS07845	COG3829	transcription factor binding
K3F53_RS07850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K3F53_RS07860	COG1115	amino acid carrier protein
K3F53_RS07865	COG0252	asparaginase activity
K3F53_RS07870	COG1396	sequence-specific DNA binding
K3F53_RS07875	COG5377	YqaJ viral recombinase family
K3F53_RS07880	COG3723	Recombinational DNA repair protein, rece pathway
K3F53_RS07885	COG1950	PFAM Membrane protein of
K3F53_RS07910	COG0586	Pfam SNARE associated Golgi protein
K3F53_RS07915	COG0740	serine-type endopeptidase activity
K3F53_RS07955	COG0442	prolyl-tRNA aminoacylation
K3F53_RS07970	COG1131	(ABC) transporter
K3F53_RS07980	COG1595	DNA-templated transcription, initiation
K3F53_RS07985	COG4980	gas vesicle protein
K3F53_RS07985	COG1674	ftsk spoiiie
K3F53_RS07990	COG0517	IMP dehydrogenase activity
K3F53_RS08000	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K3F53_RS08010	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K3F53_RS08030	COG0427	acetyl-CoA hydrolase
K3F53_RS08035	COG0210	DNA helicase
K3F53_RS08040	COG2996	Protein conserved in bacteria
K3F53_RS08065	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3F53_RS08065	COG1024	Enoyl-CoA hydratase
K3F53_RS08070	COG0183	Belongs to the thiolase family
K3F53_RS08075	COG1960	acyl-CoA dehydrogenase activity
K3F53_RS08080	COG0318	PFAM AMP-dependent synthetase and ligase
K3F53_RS08090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K3F53_RS08095	COG1164	Oligoendopeptidase f
K3F53_RS08100	COG0860	N-Acetylmuramoyl-L-alanine amidase
K3F53_RS08100	COG2247	cell wall binding repeat
K3F53_RS08105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K3F53_RS08110	COG0671	phosphoesterase, PA-phosphatase related
K3F53_RS08135	COG1396	sequence-specific DNA binding
K3F53_RS08170	COG2885	chlorophyll binding
K3F53_RS08190	COG2962	Rard protein
K3F53_RS08195	COG1388	LysM domain
K3F53_RS08195	COG3858	chitin binding
K3F53_RS08200	COG1506	peptidase
K3F53_RS08210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3F53_RS08215	COG1482	cell wall glycoprotein biosynthetic process
K3F53_RS08220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K3F53_RS08240	COG1940	carbohydrate kinase activity
K3F53_RS08245	COG2204	response regulator
K3F53_RS08250	COG3852	Histidine kinase
K3F53_RS08260	COG1454	alcohol dehydrogenase
K3F53_RS08270	COG0506	proline dehydrogenase activity
K3F53_RS08280	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K3F53_RS08285	COG0352	thiamine-phosphate diphosphorylase activity
K3F53_RS08290	COG0187	DNA topoisomerase II activity
K3F53_RS08295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K3F53_RS08300	COG1098	S1 RNA binding domain
K3F53_RS08305	COG0540	Belongs to the ATCase OTCase family
K3F53_RS08310	COG1164	Oligoendopeptidase f
K3F53_RS08320	COG0066	3-isopropylmalate dehydratase activity
K3F53_RS08325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K3F53_RS08330	COG0583	DNA-binding transcription factor activity
K3F53_RS08335	COG2843	Capsule synthesis protein
K3F53_RS08350	COG2002	toxin-antitoxin pair type II binding
K3F53_RS08395	COG0457	Tetratricopeptide repeat
K3F53_RS08395	COG0463	Glycosyl transferase, family 2
K3F53_RS08400	COG0457	Tetratricopeptide repeat
K3F53_RS08400	COG0463	Glycosyl transferase, family 2
K3F53_RS08410	COG0662	Cupin 2, conserved barrel domain protein
K3F53_RS08410	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
K3F53_RS08415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K3F53_RS08430	COG1199	ATP-dependent helicase activity
K3F53_RS08435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K3F53_RS08455	COG3773	Cell wall hydrolase
K3F53_RS08460	COG2084	Dehydrogenase
K3F53_RS08470	COG0833	amino acid
K3F53_RS08480	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K3F53_RS08485	COG0745	RESPONSE REGULATOR receiver
K3F53_RS08490	COG5002	protein histidine kinase activity
K3F53_RS08495	COG1136	(ABC) transporter
K3F53_RS08500	COG0577	efflux transmembrane transporter activity
K3F53_RS08505	COG0656	L-ascorbic acid biosynthetic process
K3F53_RS08510	COG1164	Oligoendopeptidase f
K3F53_RS08515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3F53_RS08520	COG2056	Na+-H+ antiporter family
K3F53_RS08535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K3F53_RS08540	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K3F53_RS08545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K3F53_RS08560	COG4810	utilization protein
K3F53_RS08565	COG4917	ethanolamine utilization protein
K3F53_RS08580	COG4819	ethanolamine utilization protein
K3F53_RS08585	COG4303	Ethanolamine ammonia lyase large subunit
K3F53_RS08590	COG4302	ethanolamine ammonia-lyase activity
K3F53_RS08595	COG4816	utilization protein
K3F53_RS08600	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS08600	COG1454	alcohol dehydrogenase
K3F53_RS08615	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
K3F53_RS08625	COG4303	Ethanolamine ammonia lyase large subunit
K3F53_RS08630	COG4302	ethanolamine ammonia-lyase activity
K3F53_RS08635	COG3192	ethanolamine utilization protein
K3F53_RS08650	COG0527	aspartate kinase activity
K3F53_RS08805	COG0419	ATPase involved in DNA repair
K3F53_RS08810	COG1401	restriction endodeoxyribonuclease activity
K3F53_RS08830	COG2217	Heavy metal translocating P-type atpase
K3F53_RS08840	COG2608	mercury ion transmembrane transporter activity
K3F53_RS08865	COG0860	N-Acetylmuramoyl-L-alanine amidase
K3F53_RS08870	COG2186	Transcriptional regulator
K3F53_RS08875	COG2807	transmembrane transport
K3F53_RS08885	COG0456	acetyltransferase
K3F53_RS08900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3F53_RS08905	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K3F53_RS08920	COG0582	viral genome integration into host DNA
K3F53_RS08950	COG2801	Transposase and inactivated derivatives
K3F53_RS08965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3F53_RS08990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K3F53_RS09010	COG0733	neurotransmitter:sodium symporter activity
K3F53_RS09015	COG3483	tryptophan 2,3-dioxygenase activity
K3F53_RS09025	COG3844	kynureninase activity
K3F53_RS09030	COG1309	transcriptional regulator
K3F53_RS09035	COG3048	D-serine ammonia-lyase activity
K3F53_RS09040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K3F53_RS09050	COG0644	oxidoreductase
K3F53_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS09070	COG2186	Transcriptional regulator
K3F53_RS09085	COG4869	propanediol catabolic process
K3F53_RS09090	COG0686	Belongs to the AlaDH PNT family
K3F53_RS09095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3F53_RS09100	COG1113	amino acid transport
K3F53_RS09105	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K3F53_RS09110	COG0551	DNA topoisomerase type I activity
K3F53_RS09110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3F53_RS09115	COG1607	acyl-coa hydrolase
K3F53_RS09120	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K3F53_RS09130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3F53_RS09140	COG0840	transmembrane signaling receptor activity
K3F53_RS09145	COG0534	Mate efflux family protein
K3F53_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS09160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3F53_RS09165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K3F53_RS09170	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K3F53_RS09175	COG1074	ATP-dependent DNA helicase activity
K3F53_RS09180	COG3584	3D domain protein
K3F53_RS09180	COG1388	LysM domain
K3F53_RS09200	COG1547	Domain of unknown function (DUF309)
K3F53_RS09205	COG0084	hydrolase, TatD family'
K3F53_RS09235	COG0277	FAD linked oxidase domain protein
K3F53_RS09240	COG0247	lactate metabolic process
K3F53_RS09245	COG0277	FAD linked oxidase domain protein
K3F53_RS09255	COG2211	Major facilitator Superfamily
K3F53_RS09310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3F53_RS09340	COG0840	transmembrane signaling receptor activity
K3F53_RS09355	COG4224	UPF0291 protein
K3F53_RS09360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3F53_RS09365	COG0791	NLP P60 protein
K3F53_RS09365	COG1388	LysM domain
K3F53_RS09370	COG1252	NADH dehydrogenase
K3F53_RS09375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3F53_RS09380	COG0798	PFAM Bile acid sodium symporter
K3F53_RS09385	COG0640	Transcriptional regulator
K3F53_RS09395	COG1401	restriction endodeoxyribonuclease activity
K3F53_RS09395	COG1401	restriction endodeoxyribonuclease activity
K3F53_RS09405	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS09415	COG1404	Belongs to the peptidase S8 family
K3F53_RS09440	COG0583	DNA-binding transcription factor activity
K3F53_RS09445	COG1380	Effector of murein hydrolase LrgA
K3F53_RS09450	COG1346	cytolysis
K3F53_RS09460	COG5018	Exonuclease
K3F53_RS09465	COG1611	Belongs to the LOG family
K3F53_RS09480	COG0741	lytic transglycosylase activity
K3F53_RS09490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K3F53_RS09495	COG4709	membrane
K3F53_RS09500	COG3949	Membrane
K3F53_RS09505	COG0189	ligase activity
K3F53_RS09525	COG0561	phosphatase activity
K3F53_RS09530	COG0243	molybdopterin cofactor binding
K3F53_RS09535	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K3F53_RS09545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K3F53_RS09550	COG0583	DNA-binding transcription factor activity
K3F53_RS09570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K3F53_RS09575	COG0488	(ABC) transporter
K3F53_RS09610	COG0314	molybdopterin synthase activity
K3F53_RS09615	COG1763	Mo-molybdopterin cofactor biosynthetic process
K3F53_RS09620	COG0303	'Molybdopterin
K3F53_RS09625	COG0746	molybdenum cofactor guanylyltransferase activity
K3F53_RS09630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3F53_RS09640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K3F53_RS09645	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K3F53_RS09650	COG1464	Belongs to the NlpA lipoprotein family
K3F53_RS09660	COG0183	Belongs to the thiolase family
K3F53_RS09665	COG1376	ErfK ybiS ycfS ynhG family protein
K3F53_RS09670	COG0521	Mo-molybdopterin cofactor biosynthetic process
K3F53_RS09675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3F53_RS09685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K3F53_RS09700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K3F53_RS09715	COG0427	acetyl-CoA hydrolase
K3F53_RS09720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K3F53_RS09730	COG0460	homoserine dehydrogenase
K3F53_RS09735	COG4086	secreted protein
K3F53_RS09740	COG0393	Putative heavy-metal-binding
K3F53_RS09745	COG1331	Highly conserved protein containing a thioredoxin domain
K3F53_RS09750	COG1331	Highly conserved protein containing a thioredoxin domain
K3F53_RS09760	COG1215	transferase activity, transferring glycosyl groups
K3F53_RS09765	COG0438	transferase activity, transferring glycosyl groups
K3F53_RS09820	COG2801	Transposase and inactivated derivatives
K3F53_RS09830	COG0488	(ABC) transporter
K3F53_RS09850	COG1131	(ABC) transporter
K3F53_RS09870	COG2197	response regulator
K3F53_RS09875	COG3850	Histidine kinase
K3F53_RS09880	COG0730	response to heat
K3F53_RS09885	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K3F53_RS09890	COG4721	ABC-type cobalt transport system, permease component
K3F53_RS09895	COG1122	ATPase activity
K3F53_RS09900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K3F53_RS09910	COG1132	(ABC) transporter
K3F53_RS09945	COG0745	RESPONSE REGULATOR receiver
K3F53_RS09955	COG0174	glutamine synthetase
K3F53_RS09960	COG0789	Transcriptional regulator
K3F53_RS09965	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K3F53_RS09970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K3F53_RS09990	COG0784	Response regulator, receiver
K3F53_RS09990	COG0835	chemotaxis
K3F53_RS10005	COG0833	amino acid
K3F53_RS10015	COG1764	response to oxidative stress
K3F53_RS10030	COG0531	amino acid
K3F53_RS10035	COG0697	spore germination
K3F53_RS10040	COG1556	Lactate utilization protein
K3F53_RS10045	COG1139	Iron-sulfur cluster binding protein
K3F53_RS10050	COG0247	lactate metabolic process
K3F53_RS10065	COG2045	Belongs to the ComB family
K3F53_RS10070	COG2707	UPF0756 membrane protein
K3F53_RS10075	COG2814	Major facilitator Superfamily
K3F53_RS10080	COG1809	phosphosulfolactate synthase activity
K3F53_RS10090	COG2814	Major facilitator Superfamily
K3F53_RS10100	COG0534	Mate efflux family protein
K3F53_RS10105	COG1349	DNA-binding transcription factor activity
K3F53_RS10120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K3F53_RS10130	COG3842	ATPase activity
K3F53_RS10135	COG1840	ABC-type Fe3 transport system, periplasmic component
K3F53_RS10145	COG0778	Nitroreductase
K3F53_RS10150	COG2819	hydrolase of the alpha beta superfamily
K3F53_RS10155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS10160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS10165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K3F53_RS10170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K3F53_RS10170	COG2207	Transcriptional regulator
K3F53_RS10185	COG1378	Sugar-specific transcriptional regulator TrmB
K3F53_RS10200	COG1309	transcriptional regulator
K3F53_RS10210	COG1271	oxidase subunit
K3F53_RS10215	COG1294	oxidase, subunit
K3F53_RS10235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3F53_RS10240	COG0438	transferase activity, transferring glycosyl groups
K3F53_RS10245	COG0438	transferase activity, transferring glycosyl groups
K3F53_RS10260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K3F53_RS10270	COG1984	allophanate hydrolase subunit 2
K3F53_RS10280	COG3829	transcription factor binding
K3F53_RS10280	COG3290	protein histidine kinase activity
K3F53_RS10285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K3F53_RS10290	COG0439	Biotin carboxylase
K3F53_RS10300	COG1984	allophanate hydrolase subunit 2
K3F53_RS10310	COG5002	protein histidine kinase activity
K3F53_RS10325	COG1309	transcriptional regulator
K3F53_RS10340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K3F53_RS10350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K3F53_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS10360	COG3835	regulator
K3F53_RS10375	COG0840	transmembrane signaling receptor activity
K3F53_RS10400	COG4948	Mandelate Racemase Muconate Lactonizing
K3F53_RS10410	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K3F53_RS10415	COG2076	Multidrug Resistance protein
K3F53_RS10420	COG3693	PFAM glycoside hydrolase, family 10
K3F53_RS10460	COG2801	Transposase and inactivated derivatives
K3F53_RS10485	COG3290	protein histidine kinase activity
K3F53_RS10500	COG0716	FMN binding
K3F53_RS10510	COG3335	DDE superfamily endonuclease
K3F53_RS10530	COG3335	DDE superfamily endonuclease
K3F53_RS10540	COG1716	ATPase activity
K3F53_RS10540	COG1131	(ABC) transporter
K3F53_RS10540	COG0842	Transport permease protein
K3F53_RS10550	COG2258	MOSC domain
K3F53_RS10560	COG1309	transcriptional regulator
K3F53_RS10565	COG1566	PFAM secretion protein HlyD family protein
K3F53_RS10570	COG2814	Major facilitator Superfamily
K3F53_RS10580	COG0464	growth
K3F53_RS10585	COG2340	Cysteine-rich secretory protein family
K3F53_RS10620	COG2011	ABC-type metal ion transport system permease component
K3F53_RS10625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K3F53_RS10630	COG1923	regulation of RNA biosynthetic process
K3F53_RS10635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K3F53_RS10640	COG2136	Putative SAM-dependent methyltransferase
K3F53_RS10640	COG2521	methyltransferase
K3F53_RS10665	COG0431	NADPH-dependent FMN reductase
K3F53_RS10675	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS10680	COG2151	metal-sulfur cluster biosynthetic enzyme
K3F53_RS10695	COG3396	Phenylacetate-CoA oxygenase
K3F53_RS10705	COG0183	Belongs to the thiolase family
K3F53_RS10710	COG0183	Belongs to the thiolase family
K3F53_RS10715	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3F53_RS10720	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3F53_RS10725	COG1024	Enoyl-CoA hydratase
K3F53_RS10735	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K3F53_RS10740	COG1024	Enoyl-CoA hydratase
K3F53_RS10745	COG1114	Component of the transport system for branched-chain amino acids
K3F53_RS10755	COG0697	spore germination
K3F53_RS10765	COG2076	Multidrug Resistance protein
K3F53_RS10770	COG2076	Multidrug Resistance protein
K3F53_RS10785	COG1215	transferase activity, transferring glycosyl groups
K3F53_RS10800	COG4191	Histidine kinase
K3F53_RS10810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K3F53_RS10835	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K3F53_RS10875	COG0860	N-Acetylmuramoyl-L-alanine amidase
K3F53_RS11010	COG2868	ribosomal protein
K3F53_RS11100	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K3F53_RS11130	COG1484	DNA-dependent DNA replication
K3F53_RS11195	COG1396	sequence-specific DNA binding
K3F53_RS11260	COG0084	hydrolase, TatD family'
K3F53_RS11305	COG0582	viral genome integration into host DNA
K3F53_RS11310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K3F53_RS11315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K3F53_RS11320	COG0527	aspartate kinase activity
K3F53_RS11325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K3F53_RS11330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3F53_RS11335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K3F53_RS11345	COG0756	dUTP diphosphatase activity
K3F53_RS11350	COG0612	Peptidase, M16
K3F53_RS11355	COG0726	polysaccharide deacetylase
K3F53_RS11360	COG1185	polyribonucleotide nucleotidyltransferase activity
K3F53_RS11365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K3F53_RS11370	COG0196	riboflavin kinase activity
K3F53_RS11375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K3F53_RS11380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K3F53_RS11385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K3F53_RS11390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K3F53_RS11395	COG1358	cellular component organization or biogenesis
K3F53_RS11400	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K3F53_RS11405	COG0195	Participates in both transcription termination and antitermination
K3F53_RS11410	COG0779	Required for maturation of 30S ribosomal subunits
K3F53_RS11415	COG2176	DNA-directed DNA polymerase activity
K3F53_RS11420	COG0442	prolyl-tRNA aminoacylation
K3F53_RS11425	COG0750	zinc metalloprotease
K3F53_RS11430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K3F53_RS11435	COG4589	Belongs to the CDS family
K3F53_RS11440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K3F53_RS11445	COG0233	cytoplasmic translational termination
K3F53_RS11450	COG0528	UMP kinase activity
K3F53_RS11455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K3F53_RS11460	COG0052	Belongs to the universal ribosomal protein uS2 family
K3F53_RS11480	COG1191	sigma factor activity
K3F53_RS11490	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K3F53_RS11495	COG1776	CheC inhibitor of MCP methylation
K3F53_RS11500	COG0835	chemotaxis
K3F53_RS11505	COG2198	Histidine kinase
K3F53_RS11505	COG0643	Histidine kinase
K3F53_RS11510	COG2201	protein-glutamate methylesterase activity
K3F53_RS11515	COG0455	bacterial-type flagellum organization
K3F53_RS11520	COG1419	protein localization to endoplasmic reticulum
K3F53_RS11525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3F53_RS11530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K3F53_RS11535	COG1684	flagellar biosynthetic protein fliR
K3F53_RS11540	COG1987	bacterial-type flagellum assembly
K3F53_RS11545	COG1338	Plays a role in the flagellum-specific transport system
K3F53_RS11550	COG3190	flagellar
K3F53_RS11555	COG2201	protein-glutamate methylesterase activity
K3F53_RS11560	COG1776	CheC inhibitor of MCP methylation
K3F53_RS11560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3F53_RS11565	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3F53_RS11575	COG1582	Flagellar protein (FlbD)
K3F53_RS11580	COG4786	Flagellar basal body rod
K3F53_RS11590	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K3F53_RS11595	COG3144	bacterial-type flagellum assembly
K3F53_RS11605	COG2882	bacterial-type flagellum organization
K3F53_RS11610	COG1157	protein secretion by the type III secretion system
K3F53_RS11620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K3F53_RS11625	COG1766	The M ring may be actively involved in energy transduction
K3F53_RS11630	COG1677	Flagellar hook-basal body complex protein FliE
K3F53_RS11635	COG1558	bacterial-type flagellum-dependent cell motility
K3F53_RS11640	COG1815	bacterial-type flagellum-dependent cell motility
K3F53_RS11650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K3F53_RS11655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K3F53_RS11660	COG4974	Belongs to the 'phage' integrase family
K3F53_RS11665	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K3F53_RS11670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K3F53_RS11675	COG0758	DNA mediated transformation
K3F53_RS11675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K3F53_RS11680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K3F53_RS11685	COG0045	succinate-CoA ligase (ADP-forming) activity
K3F53_RS11700	COG0792	nuclease activity
K3F53_RS11705	COG2257	FlhB HrpN YscU SpaS Family
K3F53_RS11715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K3F53_RS11725	COG0681	Belongs to the peptidase S26 family
K3F53_RS11730	COG0335	large ribosomal subunit rRNA binding
K3F53_RS11735	COG0336	Belongs to the RNA methyltransferase TrmD family
K3F53_RS11740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K3F53_RS11750	COG1837	Belongs to the UPF0109 family
K3F53_RS11755	COG0228	four-way junction DNA binding
K3F53_RS11760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K3F53_RS11765	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K3F53_RS11770	COG0552	protein localization to endoplasmic reticulum
K3F53_RS11775	COG1196	nuclear chromosome segregation
K3F53_RS11780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3F53_RS11785	COG0571	ribonuclease III activity
K3F53_RS11790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3F53_RS11795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3F53_RS11800	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS11805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K3F53_RS11815	COG0416	fatty acid biosynthetic process
K3F53_RS11835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K3F53_RS11845	COG1323	Belongs to the UPF0348 family
K3F53_RS11850	COG3480	Lon protease (S16) C-terminal proteolytic domain
K3F53_RS11855	COG1752	Esterase of the alpha-beta hydrolase superfamily
K3F53_RS11860	COG3314	Sporulation integral membrane protein YlbJ
K3F53_RS11865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K3F53_RS11870	COG0742	ribosomal rna small subunit methyltransferase
K3F53_RS11875	COG1285	pathogenesis
K3F53_RS11880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K3F53_RS11885	COG1760	l-serine dehydratase
K3F53_RS11890	COG1760	l-serine dehydratase
K3F53_RS11895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K3F53_RS11905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K3F53_RS11910	COG1162	GTPase activity
K3F53_RS11915	COG0515	serine threonine protein kinase
K3F53_RS11915	COG2815	serine threonine protein kinase
K3F53_RS11920	COG0631	protein serine/threonine phosphatase activity
K3F53_RS11925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K3F53_RS11930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3F53_RS11930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3F53_RS11935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K3F53_RS11940	COG0242	peptide deformylase activity
K3F53_RS11945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K3F53_RS11950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K3F53_RS11955	COG1758	RNA polymerase activity
K3F53_RS11960	COG0194	GDP metabolic process
K3F53_RS11965	COG2052	Domain of unknown function (DUF370)
K3F53_RS11970	COG1561	YicC-like family, N-terminal region
K3F53_RS11975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K3F53_RS11980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K3F53_RS11990	COG2244	polysaccharide biosynthetic process
K3F53_RS11995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K3F53_RS12000	COG0284	orotidine-5'-phosphate decarboxylase activity
K3F53_RS12005	COG0167	dihydroorotate dehydrogenase activity
K3F53_RS12010	COG0543	2 iron, 2 sulfur cluster binding
K3F53_RS12015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K3F53_RS12020	COG0505	Belongs to the CarA family
K3F53_RS12025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K3F53_RS12035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K3F53_RS12040	COG0564	pseudouridine synthase activity
K3F53_RS12045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K3F53_RS12050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K3F53_RS12055	COG3599	regulation of cell shape
K3F53_RS12060	COG2302	S4 RNA-binding domain
K3F53_RS12065	COG0762	integral membrane protein
K3F53_RS12070	COG1799	cell septum assembly
K3F53_RS12075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K3F53_RS12080	COG1496	oxidoreductase activity
K3F53_RS12085	COG1873	PFAM PRC-barrel domain
K3F53_RS12095	COG1191	sigma factor activity
K3F53_RS12100	COG1191	sigma factor activity
K3F53_RS12110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K3F53_RS12115	COG0849	cell division
K3F53_RS12120	COG3856	small basic protein
K3F53_RS12135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K3F53_RS12140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3F53_RS12145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K3F53_RS12150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K3F53_RS12155	COG0772	Belongs to the SEDS family
K3F53_RS12160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K3F53_RS12165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3F53_RS12175	COG0768	penicillin binding
K3F53_RS12180	COG0768	penicillin binding
K3F53_RS12190	COG0275	rRNA processing
K3F53_RS12200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
K3F53_RS12205	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K3F53_RS12210	COG1309	transcriptional regulator
K3F53_RS12215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K3F53_RS12220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3F53_RS12225	COG0511	ligase activity, forming carbon-carbon bonds
K3F53_RS12230	COG0439	Biotin carboxylase
K3F53_RS12240	COG1024	Enoyl-CoA hydratase
K3F53_RS12245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K3F53_RS12250	COG1393	Belongs to the ArsC family
K3F53_RS12275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K3F53_RS12280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K3F53_RS12305	COG3290	protein histidine kinase activity
K3F53_RS12305	COG3829	transcription factor binding
K3F53_RS12320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K3F53_RS12330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3F53_RS12340	COG4493	Belongs to the UPF0637 family
K3F53_RS12350	COG1982	Orn Lys Arg decarboxylase major
K3F53_RS12395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K3F53_RS12405	COG2153	protein acetylation
K3F53_RS12410	COG0613	PHP domain protein
K3F53_RS12420	COG0745	RESPONSE REGULATOR receiver
K3F53_RS12425	COG0750	zinc metalloprotease
K3F53_RS12430	COG0497	DNA recombination
K3F53_RS12435	COG1438	arginine binding
K3F53_RS12440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K3F53_RS12445	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K3F53_RS12450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K3F53_RS12460	COG1722	exodeoxyribonuclease VII activity
K3F53_RS12465	COG1570	exodeoxyribonuclease VII activity
K3F53_RS12470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K3F53_RS12475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K3F53_RS12480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K3F53_RS12495	COG1302	Protein conserved in bacteria
K3F53_RS12500	COG0439	Biotin carboxylase
K3F53_RS12505	COG0511	ligase activity, forming carbon-carbon bonds
K3F53_RS12545	COG3854	ATPases associated with a variety of cellular activities
K3F53_RS12555	COG2814	Major facilitator Superfamily
K3F53_RS12560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K3F53_RS12565	COG0006	proline dipeptidase activity
K3F53_RS12575	COG2010	Cytochrome c
K3F53_RS12580	COG3872	metal-dependent enzyme
K3F53_RS12590	COG1752	Esterase of the alpha-beta hydrolase superfamily
K3F53_RS12595	COG1321	iron dependent repressor
K3F53_RS12610	COG1666	GTP binding
K3F53_RS12635	COG3290	protein histidine kinase activity
K3F53_RS12635	COG3829	transcription factor binding
K3F53_RS12640	COG5609	conserved protein (DUF2294)
K3F53_RS12660	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K3F53_RS12665	COG2205	protein histidine kinase activity
K3F53_RS12675	COG0095	Lipoate-protein ligase
K3F53_RS12685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K3F53_RS12690	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3F53_RS12695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K3F53_RS12700	COG0509	glycine decarboxylation via glycine cleavage system
K3F53_RS12705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K3F53_RS12725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K3F53_RS12730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K3F53_RS12745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K3F53_RS12770	COG2165	general secretion pathway protein
K3F53_RS12775	COG1459	type II secretion system
K3F53_RS12795	COG0589	response to stress
K3F53_RS12800	COG4471	UPF0298 protein
K3F53_RS12805	COG3679	Belongs to the UPF0342 family
K3F53_RS12835	COG0640	Transcriptional regulator
K3F53_RS12845	COG0463	Glycosyl transferase, family 2
K3F53_RS12850	COG3119	arylsulfatase activity
K3F53_RS12875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K3F53_RS12880	COG0387	Pfam Sodium calcium exchanger
K3F53_RS12885	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K3F53_RS12895	COG1363	Peptidase, m42
K3F53_RS12915	COG0457	Tetratricopeptide repeat
K3F53_RS12915	COG0705	Rhomboid family
K3F53_RS12920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K3F53_RS12925	COG0390	transport system, permease component
K3F53_RS12935	COG1607	acyl-coa hydrolase
K3F53_RS12955	COG0351	phosphomethylpyrimidine kinase
K3F53_RS12960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K3F53_RS12975	COG1114	Component of the transport system for branched-chain amino acids
K3F53_RS12990	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K3F53_RS13005	COG1733	regulation of RNA biosynthetic process
K3F53_RS13015	COG0584	glycerophosphoryl diester phosphodiesterase
K3F53_RS13020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3F53_RS13040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K3F53_RS13045	COG2217	Heavy metal translocating P-type atpase
K3F53_RS13050	COG0783	Belongs to the Dps family
K3F53_RS13055	COG4637	Psort location Cytoplasmic, score
K3F53_RS13060	COG4838	Belongs to the UPF0358 family
K3F53_RS13080	COG0531	amino acid
K3F53_RS13090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3F53_RS13095	COG1876	peptidase activity
K3F53_RS13120	COG2814	Major facilitator Superfamily
K3F53_RS13125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K3F53_RS13135	COG1802	Transcriptional regulator
K3F53_RS13145	COG1228	amidohydrolase
K3F53_RS13155	COG0010	Belongs to the arginase family
K3F53_RS13160	COG4977	sequence-specific DNA binding
K3F53_RS13165	COG2031	fatty acid transporter
K3F53_RS13175	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
K3F53_RS13190	COG2814	Major facilitator Superfamily
K3F53_RS13195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K3F53_RS13220	COG0471	metal ion transport
K3F53_RS13235	COG0860	N-Acetylmuramoyl-L-alanine amidase
K3F53_RS13275	COG2827	Endonuclease containing a URI domain
K3F53_RS13280	COG0312	modulator of DNA gyrase
K3F53_RS13285	COG0312	modulator of DNA gyrase
K3F53_RS13295	COG2843	Capsule synthesis protein
K3F53_RS13315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K3F53_RS13320	COG2384	SAM-dependent methyltransferase
K3F53_RS13335	COG0318	PFAM AMP-dependent synthetase and ligase
K3F53_RS13340	COG1960	acyl-CoA dehydrogenase activity
K3F53_RS13350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K3F53_RS13355	COG0358	DNA primase activity
K3F53_RS13365	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K3F53_RS13370	COG0517	IMP dehydrogenase activity
K3F53_RS13375	COG0751	glycine-tRNA ligase activity
K3F53_RS13380	COG0752	glycyl-tRNA synthetase alpha subunit
K3F53_RS13385	COG1381	Involved in DNA repair and RecF pathway recombination
K3F53_RS13395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K3F53_RS13400	COG0295	cytidine deaminase activity
K3F53_RS13405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K3F53_RS13410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K3F53_RS13415	COG1480	7TM receptor with intracellular HD hydrolase
K3F53_RS13420	COG1702	phosphate starvation-inducible protein PhoH
K3F53_RS13435	COG1610	YqeY-like protein
K3F53_RS13440	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K3F53_RS13445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K3F53_RS13450	COG1181	Belongs to the D-alanine--D-alanine ligase family
K3F53_RS13455	COG0784	Response regulator, receiver
K3F53_RS13460	COG4191	Histidine kinase
K3F53_RS13465	COG2733	membrane
K3F53_RS13470	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS13480	COG2814	Major facilitator Superfamily
K3F53_RS13500	COG1595	DNA-templated transcription, initiation
K3F53_RS13525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K3F53_RS13525	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K3F53_RS13540	COG1283	sodium-dependent phosphate transmembrane transporter activity
K3F53_RS13545	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K3F53_RS13555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K3F53_RS13560	COG1301	dicarboxylic acid transport
K3F53_RS13565	COG4565	transcriptional regulatory protein
K3F53_RS13570	COG3290	protein histidine kinase activity
K3F53_RS13575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K3F53_RS13580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K3F53_RS13605	COG0459	protein refolding
K3F53_RS13610	COG1420	regulation of RNA biosynthetic process
K3F53_RS13615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3F53_RS13620	COG0481	GTPase activity
K3F53_RS13635	COG0860	N-Acetylmuramoyl-L-alanine amidase
K3F53_RS13640	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K3F53_RS13645	COG0268	Binds directly to 16S ribosomal RNA
K3F53_RS13650	COG1466	dna polymerase III delta subunit
K3F53_RS13660	COG1595	DNA-templated transcription, initiation
K3F53_RS13665	COG2333	competence protein COMEC
K3F53_RS13665	COG0658	competence protein
K3F53_RS13690	COG1596	polysaccharide export
K3F53_RS13690	COG1555	photosystem II stabilization
K3F53_RS13700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K3F53_RS13705	COG0495	leucyl-tRNA aminoacylation
K3F53_RS13715	COG2226	methyltransferase
K3F53_RS13720	COG0799	negative regulation of ribosome biogenesis
K3F53_RS13725	COG1713	HD superfamily hydrolase involved in NAD metabolism
K3F53_RS13730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K3F53_RS13735	COG1534	Rna-binding protein
K3F53_RS13740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K3F53_RS13745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K3F53_RS13750	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K3F53_RS13760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K3F53_RS13765	COG3275	phosphorelay sensor kinase activity
K3F53_RS13770	COG3279	Response regulator of the LytR AlgR family
K3F53_RS13785	COG1966	Carbon starvation protein
K3F53_RS13805	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3F53_RS13820	COG2267	carboxylic ester hydrolase activity
K3F53_RS13825	COG0398	Pfam SNARE associated Golgi protein
K3F53_RS13830	COG1597	lipid kinase activity
K3F53_RS13835	COG0681	Belongs to the peptidase S26 family
K3F53_RS13840	COG3949	Membrane
K3F53_RS13850	COG1126	abc transporter atp-binding protein
K3F53_RS13855	COG0765	amino acid transport
K3F53_RS13860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3F53_RS13865	COG4187	Peptidase family M20/M25/M40
K3F53_RS13870	COG0778	Nitroreductase
K3F53_RS13900	COG2045	Belongs to the ComB family
K3F53_RS13910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K3F53_RS13915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K3F53_RS13920	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K3F53_RS13930	COG1027	Aspartate ammonia-lyase
K3F53_RS13945	COG1294	oxidase, subunit
K3F53_RS13950	COG1271	oxidase subunit
K3F53_RS13960	COG1388	LysM domain
K3F53_RS13960	COG3584	3D domain protein
K3F53_RS14045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3F53_RS14050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3F53_RS14065	COG0786	glutamate:sodium symporter activity
K3F53_RS14070	COG0010	Belongs to the arginase family
K3F53_RS14075	COG2204	response regulator
K3F53_RS14080	COG3852	Histidine kinase
K3F53_RS14090	COG0675	Transposase, IS605 OrfB family
K3F53_RS14095	COG0640	Transcriptional regulator
K3F53_RS14100	COG2217	Heavy metal translocating P-type atpase
K3F53_RS14105	COG4607	ABC-type enterochelin transport system periplasmic component
K3F53_RS14110	COG4604	ABC transporter, ATP-binding protein
K3F53_RS14115	COG4605	iron ion homeostasis
K3F53_RS14120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS14150	COG0675	Transposase, IS605 OrfB family
K3F53_RS14175	COG1346	cytolysis
K3F53_RS14180	COG1380	Effector of murein hydrolase LrgA
K3F53_RS14190	COG2224	Isocitrate lyase
K3F53_RS14195	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K3F53_RS14200	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K3F53_RS14205	COG3853	Toxic anion resistance protein (TelA)
K3F53_RS14220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3F53_RS14230	COG4638	Rieske (2fe-2S)
K3F53_RS14235	COG3829	transcription factor binding
K3F53_RS14240	COG0473	3-isopropylmalate dehydrogenase activity
K3F53_RS14245	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS14250	COG0318	PFAM AMP-dependent synthetase and ligase
K3F53_RS14270	COG0028	Belongs to the TPP enzyme family
K3F53_RS14285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K3F53_RS14305	COG1131	(ABC) transporter
K3F53_RS14310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K3F53_RS14355	COG0789	Transcriptional regulator
K3F53_RS14360	COG3253	May function as heme-dependent peroxidase
K3F53_RS14365	COG0768	penicillin binding
K3F53_RS14370	COG0572	uridine kinase
K3F53_RS14375	COG0826	peptidase U32
K3F53_RS14380	COG0826	peptidase U32
K3F53_RS14385	COG4122	O-methyltransferase activity
K3F53_RS14390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K3F53_RS14410	COG3906	Belongs to the UPF0473 family
K3F53_RS14420	COG4472	Bacterial protein of unknown function (DUF965)
K3F53_RS14425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K3F53_RS14430	COG0628	permease
K3F53_RS14445	COG0840	transmembrane signaling receptor activity
K3F53_RS14465	COG1104	cysteine desulfurase activity
K3F53_RS14470	COG1959	2 iron, 2 sulfur cluster binding
K3F53_RS14480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K3F53_RS14490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K3F53_RS14495	COG0124	histidyl-tRNA synthetase
K3F53_RS14500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K3F53_RS14510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K3F53_RS14515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3F53_RS14520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K3F53_RS14520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K3F53_RS14540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3F53_RS14540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3F53_RS14545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3F53_RS14545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K3F53_RS14555	COG2244	polysaccharide biosynthetic process
K3F53_RS14560	COG0598	Magnesium transport protein CorA
K3F53_RS14570	COG1862	Preprotein translocase
K3F53_RS14575	COG0343	queuine tRNA-ribosyltransferase activity
K3F53_RS14580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K3F53_RS14585	COG2247	cell wall binding repeat
K3F53_RS14585	COG2385	sporulation resulting in formation of a cellular spore
K3F53_RS14595	COG1846	Transcriptional regulator
K3F53_RS14600	COG2364	Membrane
K3F53_RS14610	COG2255	four-way junction helicase activity
K3F53_RS14615	COG0632	four-way junction helicase activity
K3F53_RS14635	COG0217	transcriptional regulatory protein
K3F53_RS14640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K3F53_RS14645	COG0077	Prephenate dehydratase
K3F53_RS14650	COG0083	homoserine kinase activity
K3F53_RS14655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K3F53_RS14660	COG0460	homoserine dehydrogenase
K3F53_RS14665	COG4492	Belongs to the UPF0735 family
K3F53_RS14670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K3F53_RS14675	COG3290	protein histidine kinase activity
K3F53_RS14680	COG0028	Belongs to the TPP enzyme family
K3F53_RS14685	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K3F53_RS14690	COG2868	ribosomal protein
K3F53_RS14695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K3F53_RS14700	COG1530	ribonuclease E activity
K3F53_RS14705	COG1994	Peptidase M50
K3F53_RS14715	COG0772	Belongs to the SEDS family
K3F53_RS14720	COG2894	cell division
K3F53_RS14725	COG0850	regulation of cytokinetic process
K3F53_RS14740	COG1077	Cell shape determining protein MreB Mrl
K3F53_RS14745	COG2003	Belongs to the UPF0758 family
K3F53_RS14750	COG0424	maF-like protein
K3F53_RS14775	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K3F53_RS14785	COG1459	type II secretion system
K3F53_RS14795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K3F53_RS14835	COG0840	transmembrane signaling receptor activity
K3F53_RS14840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K3F53_RS14845	COG0285	dihydrofolate synthase activity
K3F53_RS14850	COG0525	valine-tRNA ligase activity
K3F53_RS14855	COG1136	(ABC) transporter
K3F53_RS14895	COG1388	LysM domain
K3F53_RS14895	COG1388	LysM domain
K3F53_RS14900	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K3F53_RS14905	COG0113	porphobilinogen synthase activity
K3F53_RS14915	COG0181	hydroxymethylbilane synthase activity
K3F53_RS14920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K3F53_RS14925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K3F53_RS14930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K3F53_RS14945	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K3F53_RS14955	COG0470	DNA polymerase III
K3F53_RS14955	COG1067	ATP-dependent peptidase activity
K3F53_RS14960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K3F53_RS14965	COG0740	serine-type endopeptidase activity
K3F53_RS14970	COG0544	peptidyl-prolyl cis-trans isomerase activity
K3F53_RS14985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K3F53_RS14990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K3F53_RS14995	COG5401	PFAM Sporulation and spore germination
K3F53_RS15015	COG1063	alcohol dehydrogenase
K3F53_RS15020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3F53_RS15025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K3F53_RS15030	COG0508	dehydrogenase complex catalyzes the overall conversion of
K3F53_RS15035	COG0022	dehydrogenase e1 component
K3F53_RS15040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K3F53_RS15045	COG0321	lipoyl(octanoyl) transferase activity
K3F53_RS15050	COG3284	Transcriptional regulator
K3F53_RS15060	COG2172	sigma factor antagonist activity
K3F53_RS15065	COG1191	sigma factor activity
K3F53_RS15070	COG2197	response regulator
K3F53_RS15085	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K3F53_RS15090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K3F53_RS15095	COG1053	succinate dehydrogenase
K3F53_RS15100	COG2009	succinate dehydrogenase
K3F53_RS15105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K3F53_RS15110	COG1268	BioY protein
K3F53_RS15120	COG0322	excinuclease ABC activity
K3F53_RS15125	COG3118	belongs to the thioredoxin family
K3F53_RS15130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K3F53_RS15135	COG2086	electron transfer activity
K3F53_RS15140	COG1024	Enoyl-CoA hydratase
K3F53_RS15145	COG1309	transcriptional regulator
K3F53_RS15150	COG3278	Belongs to the heme-copper respiratory oxidase family
K3F53_RS15165	COG4572	Cation transport regulator
K3F53_RS15170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K3F53_RS15175	COG0506	proline dehydrogenase activity
K3F53_RS15180	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS15195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K3F53_RS15200	COG0728	peptidoglycan biosynthetic process
K3F53_RS15240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K3F53_RS15245	COG1279	arginine transmembrane transporter activity
K3F53_RS15255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K3F53_RS15260	COG3766	membrane
K3F53_RS15265	COG1193	negative regulation of DNA recombination
K3F53_RS15270	COG0531	amino acid
K3F53_RS15275	COG0583	DNA-binding transcription factor activity
K3F53_RS15280	COG1286	toxin biosynthetic process
K3F53_RS15285	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K3F53_RS15290	COG0072	phenylalanine-tRNA ligase activity
K3F53_RS15290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K3F53_RS15295	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K3F53_RS15305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K3F53_RS15310	COG0569	domain protein
K3F53_RS15320	COG1363	Peptidase, m42
K3F53_RS15330	COG2155	Conserved Protein
K3F53_RS15355	COG0473	3-isopropylmalate dehydrogenase activity
K3F53_RS15360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K3F53_RS15365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K3F53_RS15370	COG0440	acetolactate synthase activity
K3F53_RS15375	COG0028	Belongs to the TPP enzyme family
K3F53_RS15385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K3F53_RS15390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K3F53_RS15395	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K3F53_RS15400	COG3584	3D domain protein
K3F53_RS15425	COG1252	NADH dehydrogenase
K3F53_RS15445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K3F53_RS15450	COG0316	Belongs to the HesB IscA family
K3F53_RS15455	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K3F53_RS15470	COG4837	Protein of unknown function (DUF1462)
K3F53_RS15475	COG0626	cystathionine gamma-synthase activity
K3F53_RS15480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K3F53_RS15485	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K3F53_RS15490	COG0583	DNA-binding transcription factor activity
K3F53_RS15495	COG2814	Major facilitator Superfamily
K3F53_RS15500	COG0494	nUDIX hydrolase
K3F53_RS15505	COG1028	Short-chain dehydrogenase reductase Sdr
K3F53_RS15510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K3F53_RS15515	COG0647	UMP catabolic process
K3F53_RS15520	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K3F53_RS15535	COG2445	Protein of unknown function DUF86
K3F53_RS15550	COG4470	Protein conserved in bacteria
K3F53_RS15560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K3F53_RS15565	COG0739	heme binding
K3F53_RS15570	COG1376	ErfK ybiS ycfS ynhG family protein
K3F53_RS15575	COG3963	phosphatidate phosphatase activity
K3F53_RS15580	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K3F53_RS15600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K3F53_RS15615	COG0791	NLP P60 protein
K3F53_RS15620	COG2814	Major facilitator Superfamily
K3F53_RS15630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K3F53_RS15635	COG3377	Domain of unknown function (DUF1805)
K3F53_RS15645	COG0737	Belongs to the 5'-nucleotidase family
K3F53_RS15650	COG0730	response to heat
K3F53_RS15680	COG2814	Major facilitator Superfamily
K3F53_RS15685	COG1846	Transcriptional regulator
K3F53_RS15715	COG0719	Fe-S assembly protein
K3F53_RS15720	COG0822	iron-sulfur transferase activity
K3F53_RS15725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3F53_RS15730	COG0719	Fe-S assembly protein
K3F53_RS15735	COG0396	ATPase activity
K3F53_RS15750	COG2755	lipolytic protein G-D-S-L family
K3F53_RS15755	COG1191	sigma factor activity
K3F53_RS15775	COG0509	glycine decarboxylation via glycine cleavage system
K3F53_RS15780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K3F53_RS15790	COG0436	Aminotransferase
K3F53_RS15795	COG1393	Belongs to the ArsC family
K3F53_RS15800	COG1120	ATPase activity
K3F53_RS15805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS15810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K3F53_RS15815	COG3706	GGDEF domain
K3F53_RS15825	COG1126	abc transporter atp-binding protein
K3F53_RS15830	COG0477	Major facilitator Superfamily
K3F53_RS15850	COG0697	spore germination
K3F53_RS15855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K3F53_RS15860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K3F53_RS15865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K3F53_RS15880	COG5577	PFAM Coat F domain
K3F53_RS15890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3F53_RS15905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K3F53_RS15910	COG2350	Protein conserved in bacteria
K3F53_RS15920	COG1739	Uncharacterized protein family UPF0029
K3F53_RS15925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K3F53_RS15955	COG0406	alpha-ribazole phosphatase activity
K3F53_RS15960	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K3F53_RS15965	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
K3F53_RS15970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K3F53_RS15975	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K3F53_RS15980	COG0778	Nitroreductase
K3F53_RS15990	COG1492	cobalamin metabolic process
K3F53_RS15995	COG0477	Major facilitator Superfamily
K3F53_RS16000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K3F53_RS16005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K3F53_RS16010	COG1012	belongs to the aldehyde dehydrogenase family
K3F53_RS16015	COG1956	GAF domain-containing protein
K3F53_RS16025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K3F53_RS16030	COG1757	Na H antiporter
K3F53_RS16035	COG1620	l-lactate permease
K3F53_RS16040	COG2186	Transcriptional regulator
K3F53_RS16045	COG0833	amino acid
K3F53_RS16050	COG4846	Membrane protein involved in cytochrome C biogenesis
K3F53_RS16060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K3F53_RS16070	COG0482	sulfurtransferase activity
K3F53_RS16090	COG0277	FAD linked oxidase domain protein
K3F53_RS16095	COG1119	ATPase activity
K3F53_RS16115	COG2226	methyltransferase
K3F53_RS16130	COG0686	Belongs to the AlaDH PNT family
K3F53_RS16135	COG2508	Transcriptional regulator
K3F53_RS16135	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K3F53_RS16140	COG1999	signal sequence binding
K3F53_RS16150	COG0109	protoheme IX farnesyltransferase activity
K3F53_RS16160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K3F53_RS16175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K3F53_RS16185	COG0180	Tryptophanyl-tRNA synthetase
K3F53_RS16235	COG1674	ftsk spoiiie
K3F53_RS16255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K3F53_RS16255	COG0646	methionine synthase
K3F53_RS16260	COG0646	methionine synthase
K3F53_RS16260	COG1410	methionine synthase
K3F53_RS16265	COG0784	Response regulator, receiver
K3F53_RS16265	COG3437	response regulator, receiver
K3F53_RS16285	COG1414	Transcriptional regulator
K3F53_RS16290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K3F53_RS16305	COG4221	oxidoreductase activity
K3F53_RS16305	COG3321	synthase
K3F53_RS16305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K3F53_RS16305	COG0604	alcohol dehydrogenase
K3F53_RS16320	COG2171	N-acyltransferase activity
K3F53_RS16325	COG1473	amidohydrolase
K3F53_RS16330	COG0778	Nitroreductase
K3F53_RS16335	COG3011	Protein conserved in bacteria
K3F53_RS16350	COG0741	lytic transglycosylase activity
K3F53_RS16350	COG0791	NLP P60 protein
K3F53_RS16360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K3F53_RS16370	COG4149	molybdate abc transporter
K3F53_RS16375	COG0725	ABC transporter, periplasmic molybdate-binding protein
K3F53_RS16380	COG1910	domain protein
K3F53_RS16385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K3F53_RS16390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS16395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS16415	COG4264	IucA IucC family
K3F53_RS16425	COG0019	diaminopimelate decarboxylase activity
K3F53_RS16430	COG2423	ornithine cyclodeaminase activity
K3F53_RS16440	COG2814	Major facilitator Superfamily
K3F53_RS16445	COG4264	IucA IucC family
K3F53_RS16450	COG2205	protein histidine kinase activity
K3F53_RS16450	COG2770	Histidine kinase
K3F53_RS16455	COG0745	RESPONSE REGULATOR receiver
K3F53_RS16460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3F53_RS16485	COG2755	lipolytic protein G-D-S-L family
K3F53_RS16495	COG1404	Belongs to the peptidase S8 family
K3F53_RS16530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K3F53_RS16535	COG0557	exoribonuclease II activity
K3F53_RS16540	COG1647	Serine aminopeptidase, S33
K3F53_RS16550	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K3F53_RS16555	COG0735	belongs to the Fur family
K3F53_RS16560	COG0148	phosphopyruvate hydratase activity
K3F53_RS16565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K3F53_RS16570	COG0149	triose-phosphate isomerase activity
K3F53_RS16575	COG0126	phosphoglycerate kinase activity
K3F53_RS16585	COG2390	Transcriptional regulator
K3F53_RS16595	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K3F53_RS16615	COG0740	serine-type endopeptidase activity
K3F53_RS16620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K3F53_RS16625	COG1481	regulation of sporulation
K3F53_RS16630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K3F53_RS16635	COG1660	Displays ATPase and GTPase activities
K3F53_RS16650	COG0492	ferredoxin-NADP+ reductase activity
K3F53_RS16665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K3F53_RS16665	COG0140	phosphoribosyl-ATP diphosphatase activity
K3F53_RS16670	COG0107	imidazoleglycerol-phosphate synthase activity
K3F53_RS16675	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K3F53_RS16680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K3F53_RS16685	COG0131	Imidazoleglycerol-phosphate dehydratase
K3F53_RS16690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K3F53_RS16695	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K3F53_RS16700	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K3F53_RS16725	COG0110	maltose O-acetyltransferase activity
K3F53_RS16740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K3F53_RS16745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K3F53_RS16750	COG0556	nucleotide-excision repair
K3F53_RS16765	COG3409	Peptidoglycan-binding domain 1 protein
K3F53_RS16765	COG0793	Belongs to the peptidase S41A family
K3F53_RS16770	COG4942	peptidase
K3F53_RS16775	COG2177	Part of the ABC transporter FtsEX involved in
K3F53_RS16780	COG2884	Cell division ATP-binding protein ftsE
K3F53_RS16785	COG0165	Argininosuccinate lyase
K3F53_RS16790	COG0137	argininosuccinate synthase activity
K3F53_RS16795	COG1067	ATP-dependent peptidase activity
K3F53_RS16810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K3F53_RS16815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K3F53_RS16820	COG0505	Belongs to the CarA family
K3F53_RS16830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K3F53_RS16835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K3F53_RS16845	COG3958	Transketolase
K3F53_RS16850	COG3959	Transketolase, thiamine diphosphate binding domain
K3F53_RS16860	COG0653	protein targeting
K3F53_RS16865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K3F53_RS16875	COG1278	Cold shock
K3F53_RS16880	COG0765	amino acid transport
K3F53_RS16885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K3F53_RS16910	COG1516	flagellar protein fliS
K3F53_RS16915	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K3F53_RS16995	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K3F53_RS17000	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
K3F53_RS17010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K3F53_RS17015	COG1256	bacterial-type flagellum assembly
K3F53_RS17015	COG4786	Flagellar basal body rod
K3F53_RS17025	COG2747	anti-sigma28 factor FlgM
K3F53_RS17030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K3F53_RS17045	COG1040	competence protein
K3F53_RS17050	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K3F53_RS17080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K3F53_RS17160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K3F53_RS17175	COG0367	asparagine synthase
K3F53_RS17180	COG0367	asparagine synthase
K3F53_RS17185	COG0438	transferase activity, transferring glycosyl groups
K3F53_RS17195	COG0438	transferase activity, transferring glycosyl groups
K3F53_RS17225	COG0673	inositol 2-dehydrogenase activity
K3F53_RS17245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K3F53_RS17285	COG3944	biosynthesis protein
K3F53_RS17300	COG1136	(ABC) transporter
K3F53_RS17315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K3F53_RS17320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K3F53_RS17345	COG0673	inositol 2-dehydrogenase activity
K3F53_RS17350	COG4464	protein tyrosine phosphatase activity
K3F53_RS17355	COG0489	protein tyrosine kinase activity
K3F53_RS17360	COG3944	biosynthesis protein
K3F53_RS17365	COG0436	Aminotransferase
K3F53_RS17370	COG1522	sequence-specific DNA binding
K3F53_RS17385	COG4786	Flagellar basal body rod
K3F53_RS17395	COG1609	Transcriptional regulator
K3F53_RS17400	COG0739	heme binding
K3F53_RS17405	COG2385	sporulation resulting in formation of a cellular spore
K3F53_RS17410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K3F53_RS17415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3F53_RS17425	COG4836	Membrane
K3F53_RS17430	COG1007	ATP synthesis coupled electron transport
K3F53_RS17435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3F53_RS17440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K3F53_RS17445	COG0713	ATP synthesis coupled electron transport
K3F53_RS17450	COG0839	Belongs to the complex I subunit 6 family
K3F53_RS17460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K3F53_RS17465	COG0649	NAD binding
K3F53_RS17480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K3F53_RS17485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3F53_RS17490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K3F53_RS17495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K3F53_RS17500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K3F53_RS17505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K3F53_RS17510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K3F53_RS17515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K3F53_RS17525	COG0356	it plays a direct role in the translocation of protons across the membrane
K3F53_RS17560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K3F53_RS17565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K3F53_RS17570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K3F53_RS17575	COG4475	Protein of unknown function (DUF436)
K3F53_RS17580	COG0698	ribose 5-phosphate isomerase
K3F53_RS17585	COG0840	transmembrane signaling receptor activity
K3F53_RS17590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K3F53_RS17610	COG0009	L-threonylcarbamoyladenylate synthase
K3F53_RS17620	COG2890	protein-(glutamine-N5) methyltransferase activity
K3F53_RS17625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K3F53_RS17635	COG1435	thymidine kinase activity
K3F53_RS17640	COG0254	rRNA binding
K3F53_RS17650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3F53_RS17660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K3F53_RS17665	COG1494	fructose-1,6-bisphosphatase
K3F53_RS17670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K3F53_RS17675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K3F53_RS17680	COG0191	fructose-bisphosphate aldolase activity
K3F53_RS17685	COG2204	response regulator
K3F53_RS17690	COG0504	CTP synthase activity
K3F53_RS17695	COG3343	RNA polymerase activity
K3F53_RS17700	COG1703	isobutyryl-CoA mutase activity
K3F53_RS17700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3F53_RS17700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K3F53_RS17710	COG1703	isobutyryl-CoA mutase activity
K3F53_RS17715	COG1960	acyl-CoA dehydrogenase activity
K3F53_RS17720	COG1960	acyl-CoA dehydrogenase activity
K3F53_RS17725	COG1250	3-hydroxyacyl-CoA dehydrogenase
K3F53_RS17735	COG0183	Belongs to the thiolase family
K3F53_RS17740	COG0247	lactate metabolic process
K3F53_RS17740	COG2181	nitrate reductase activity
K3F53_RS17795	COG2801	Transposase and inactivated derivatives
K3F53_RS17820	COG2801	Transposase and inactivated derivatives
K3F53_RS17840	COG0018	arginyl-trna synthetase
K3F53_RS17850	COG0010	Belongs to the arginase family
K3F53_RS17855	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K3F53_RS17865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K3F53_RS17875	COG1078	dGTPase activity
K3F53_RS17880	COG0564	pseudouridine synthase activity
K3F53_RS17885	COG4326	sporulation control protein
K3F53_RS17890	COG0475	glutathione-regulated potassium exporter activity
K3F53_RS17890	COG0569	domain protein
K3F53_RS17900	COG4844	belongs to the
K3F53_RS17910	COG0367	asparagine synthase
K3F53_RS17930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K3F53_RS17935	COG4473	ABC transporter
K3F53_RS17940	COG1131	(ABC) transporter
K3F53_RS17950	COG0697	spore germination
K3F53_RS17960	COG1295	ribonuclease BN
K3F53_RS17970	COG2363	Small membrane protein
K3F53_RS17995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K3F53_RS18000	COG1984	allophanate hydrolase subunit 2
K3F53_RS18005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K3F53_RS18010	COG1414	Transcriptional regulator
K3F53_RS18035	COG1131	(ABC) transporter
K3F53_RS18040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K3F53_RS18050	COG4841	protein insertion into membrane
K3F53_RS18110	COG0861	Integral membrane protein TerC family
K3F53_RS18130	COG1234	tRNA 3'-trailer cleavage
K3F53_RS18135	COG3853	Toxic anion resistance protein (TelA)
K3F53_RS18230	COG1115	amino acid carrier protein
K3F53_RS18235	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K3F53_RS18240	COG0765	amino acid transport
K3F53_RS18245	COG0765	amino acid transport
K3F53_RS18250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K3F53_RS18260	COG2986	histidine ammonia-lyase
K3F53_RS18285	COG2814	Major facilitator Superfamily
K3F53_RS18290	COG1566	PFAM secretion protein HlyD family protein
K3F53_RS18295	COG1846	Transcriptional regulator
K3F53_RS18305	COG0584	glycerophosphoryl diester phosphodiesterase
K3F53_RS18310	COG1653	transport
K3F53_RS18315	COG0395	ABC-type sugar transport system, permease component
K3F53_RS18320	COG1175	transmembrane transport
K3F53_RS18325	COG3842	ATPase activity
K3F53_RS18330	COG0546	phosphoglycolate phosphatase activity
K3F53_RS18340	COG4187	Peptidase family M20/M25/M40
K3F53_RS18345	COG1115	amino acid carrier protein
K3F53_RS18350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3F53_RS18350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K3F53_RS18355	COG0432	Pfam Uncharacterised protein family UPF0047
K3F53_RS18360	COG1801	Protein of unknown function DUF72
K3F53_RS18375	COG0351	phosphomethylpyrimidine kinase
K3F53_RS18380	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K3F53_RS18385	COG1845	cytochrome c oxidase, subunit III
K3F53_RS18400	COG2322	membrane
K3F53_RS18415	COG0583	DNA-binding transcription factor activity
K3F53_RS18420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K3F53_RS18425	COG0583	DNA-binding transcription factor activity
K3F53_RS18430	COG2814	Major facilitator Superfamily
K3F53_RS18435	COG0840	transmembrane signaling receptor activity
K3F53_RS18450	COG0697	spore germination
K3F53_RS18480	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K3F53_RS18485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS18490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K3F53_RS18495	COG1120	ATPase activity
K3F53_RS18515	COG1196	nuclear chromosome segregation
K3F53_RS18530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K3F53_RS18535	COG0732	type I restriction modification DNA specificity domain
K3F53_RS18540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K3F53_RS18555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3F53_RS18560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K3F53_RS18570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K3F53_RS18575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K3F53_RS18580	COG4853	Protein conserved in bacteria
K3F53_RS18585	COG4863	YycH protein
K3F53_RS18590	COG5002	protein histidine kinase activity
K3F53_RS18595	COG0745	RESPONSE REGULATOR receiver
K3F53_RS18600	COG0739	heme binding
K3F53_RS18605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K3F53_RS18610	COG0305	Participates in initiation and elongation during chromosome replication
K3F53_RS18620	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K3F53_RS18625	COG4241	membrane
K3F53_RS18630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K3F53_RS18635	COG0629	single-stranded DNA binding
K3F53_RS18640	COG0360	Binds together with S18 to 16S ribosomal RNA
K3F53_RS18645	COG0012	GTP binding
K3F53_RS18655	COG4481	Protein conserved in bacteria
K3F53_RS18660	COG0668	transmembrane transport
K3F53_RS18675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K3F53_RS18680	COG1475	DNA binding
K3F53_RS18685	COG1192	Involved in chromosome partitioning
K3F53_RS18690	COG1475	DNA binding
K3F53_RS18695	COG0357	Ribosomal RNA small subunit methyltransferase G
K3F53_RS18700	COG0445	tRNA wobble uridine modification
K3F53_RS18705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K3F53_RS18710	COG1847	R3H domain protein
K3F53_RS18715	COG0706	membrane insertase activity
K3F53_RS18725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K3F53_RS18730	COG5484	DNA packaging
K3F53_RS18855	COG4824	toxin secretion phage lysis holin
K3F53_RS18870	COG3335	DDE superfamily endonuclease
K3F53_RS18885	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3F53_RS18940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K3F53_RS19030	COG1484	DNA-dependent DNA replication
K3F53_RS19045	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K3F53_RS19135	COG1595	DNA-templated transcription, initiation
K3F53_RS19185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K3F53_RS19205	COG0582	viral genome integration into host DNA
K3F53_RS19260	COG3775	system Galactitol-specific IIC component
K3F53_RS19275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K3F53_RS19280	COG3335	DDE superfamily endonuclease
K3F53_RS19315	COG2207	Transcriptional regulator
K3F53_RS19390	COG0653	protein targeting
K3F53_RS19400	COG2234	aminopeptidase activity
K3F53_RS19505	COG3335	DDE superfamily endonuclease
K3F53_RS19530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient