locus-tag	class	description
ISX45_RS00025	COG1335	isochorismatase
ISX45_RS00030	COG1247	-acetyltransferase
ISX45_RS00035	COG2318	DinB family
ISX45_RS00045	COG2207	Transcriptional regulator
ISX45_RS00045	COG3708	Transcriptional regulator
ISX45_RS00095	COG1136	(ABC) transporter
ISX45_RS00100	COG0577	efflux transmembrane transporter activity
ISX45_RS00100	COG1136	(ABC) transporter
ISX45_RS00105	COG0745	RESPONSE REGULATOR receiver
ISX45_RS00110	COG5002	protein histidine kinase activity
ISX45_RS00120	COG1609	Transcriptional regulator
ISX45_RS00130	COG3290	protein histidine kinase activity
ISX45_RS00135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISX45_RS00140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX45_RS00145	COG1301	dicarboxylic acid transport
ISX45_RS00150	COG1741	Belongs to the pirin family
ISX45_RS00155	COG0655	NAD(P)H dehydrogenase (quinone) activity
ISX45_RS00170	COG2738	Putative neutral zinc metallopeptidase
ISX45_RS00175	COG1253	flavin adenine dinucleotide binding
ISX45_RS00180	COG0564	pseudouridine synthase activity
ISX45_RS00200	COG0366	Alpha amylase catalytic
ISX45_RS00205	COG0517	IMP dehydrogenase activity
ISX45_RS00210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISX45_RS00215	COG1785	Belongs to the alkaline phosphatase family
ISX45_RS00220	COG4221	oxidoreductase activity
ISX45_RS00225	COG4585	Histidine kinase
ISX45_RS00225	COG2203	Gaf domain
ISX45_RS00230	COG2197	response regulator
ISX45_RS00235	COG0431	NADPH-dependent FMN reductase
ISX45_RS00255	COG0586	Pfam SNARE associated Golgi protein
ISX45_RS00260	COG2719	SpoVR family
ISX45_RS00265	COG0346	lactoylglutathione lyase activity
ISX45_RS00270	COG1309	transcriptional regulator
ISX45_RS00275	COG1511	domain protein
ISX45_RS00300	COG0386	Belongs to the glutathione peroxidase family
ISX45_RS00305	COG1959	2 iron, 2 sulfur cluster binding
ISX45_RS00310	COG2910	NAD(P)H-binding
ISX45_RS00315	COG2514	catechol 2,3-dioxygenase activity
ISX45_RS00330	COG2329	Antibiotic biosynthesis monooxygenase
ISX45_RS00335	COG0697	spore germination
ISX45_RS00340	COG0716	FMN binding
ISX45_RS00350	COG0861	Integral membrane protein TerC family
ISX45_RS00355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISX45_RS00360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISX45_RS00370	COG1966	Carbon starvation protein
ISX45_RS00375	COG2879	small protein
ISX45_RS00380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISX45_RS00390	COG0366	Alpha amylase catalytic
ISX45_RS00395	COG2318	DinB family
ISX45_RS00405	COG0393	Putative heavy-metal-binding
ISX45_RS00410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISX45_RS00420	COG1122	ATPase activity
ISX45_RS00425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ISX45_RS00430	COG0352	thiamine-phosphate diphosphorylase activity
ISX45_RS00435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX45_RS00445	COG2022	thiamine diphosphate biosynthetic process
ISX45_RS00450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISX45_RS00455	COG1253	flavin adenine dinucleotide binding
ISX45_RS00460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX45_RS00465	COG0765	amino acid transport
ISX45_RS00470	COG1126	abc transporter atp-binding protein
ISX45_RS00485	COG3842	ATPase activity
ISX45_RS00490	COG2508	Transcriptional regulator
ISX45_RS00510	COG0189	ligase activity
ISX45_RS00515	COG0189	ligase activity
ISX45_RS00525	COG4399	Belongs to the UPF0754 family
ISX45_RS00530	COG3679	Belongs to the UPF0342 family
ISX45_RS00535	COG0561	phosphatase activity
ISX45_RS00540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISX45_RS00555	COG4152	abc transporter atp-binding protein
ISX45_RS00560	COG1668	transmembrane transport
ISX45_RS00565	COG3481	metal-dependent phosphohydrolase, HD sub domain
ISX45_RS00575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISX45_RS00585	COG1846	Transcriptional regulator
ISX45_RS00605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISX45_RS00610	COG0537	adenosine 5'-monophosphoramidase activity
ISX45_RS00615	COG1131	(ABC) transporter
ISX45_RS00620	COG4473	ABC transporter
ISX45_RS00625	COG2329	Antibiotic biosynthesis monooxygenase
ISX45_RS00630	COG3069	C4-dicarboxylate transmembrane transporter activity
ISX45_RS00635	COG1473	amidohydrolase
ISX45_RS00640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISX45_RS00645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISX45_RS00650	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ISX45_RS00655	COG1309	transcriptional regulator
ISX45_RS00660	COG1511	domain protein
ISX45_RS00665	COG1609	Transcriptional regulator
ISX45_RS00670	COG1653	transport
ISX45_RS00690	COG1234	tRNA 3'-trailer cleavage
ISX45_RS00700	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_RS00710	COG4120	Belongs to the binding-protein-dependent transport system permease family
ISX45_RS00715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX45_RS00730	COG1131	(ABC) transporter
ISX45_RS00735	COG2197	response regulator
ISX45_RS00740	COG4585	Histidine kinase
ISX45_RS00745	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ISX45_RS00765	COG0501	Belongs to the peptidase M48B family
ISX45_RS00775	COG2224	Isocitrate lyase
ISX45_RS00790	COG4903	ComK protein
ISX45_RS00800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISX45_RS00840	COG1522	sequence-specific DNA binding
ISX45_RS00860	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ISX45_RS00935	COG4626	Terminase
ISX45_RS00935	COG1802	Transcriptional regulator
ISX45_RS01010	COG4824	toxin secretion phage lysis holin
ISX45_RS01070	COG0398	Pfam SNARE associated Golgi protein
ISX45_RS01080	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ISX45_RS01085	COG1074	ATP-dependent DNA helicase activity
ISX45_RS01090	COG0420	3'-5' exonuclease activity
ISX45_RS01095	COG0419	ATPase involved in DNA repair
ISX45_RS01140	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_RS01145	COG2311	Membrane
ISX45_RS01155	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISX45_RS01160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISX45_RS01180	COG0367	asparagine synthase
ISX45_RS01200	COG2182	Extracellular solute-binding protein
ISX45_RS01205	COG1175	transmembrane transport
ISX45_RS01210	COG3833	ABC-type maltose transport systems, permease component
ISX45_RS01215	COG0366	Alpha amylase catalytic
ISX45_RS01215	COG1874	Beta-galactosidase
ISX45_RS01230	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISX45_RS01235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISX45_RS01240	COG1733	regulation of RNA biosynthetic process
ISX45_RS01245	COG3153	acetyltransferase
ISX45_RS01245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISX45_RS01250	COG0456	acetyltransferase
ISX45_RS01260	COG0693	protein deglycase activity
ISX45_RS01265	COG2801	Transposase and inactivated derivatives
ISX45_RS01270	COG2801	Transposase and inactivated derivatives
ISX45_RS01280	COG2814	Major facilitator Superfamily
ISX45_RS01285	COG1846	Transcriptional regulator
ISX45_RS01295	COG2124	cytochrome p450
ISX45_RS01300	COG1846	Transcriptional regulator
ISX45_RS01310	COG2801	Transposase and inactivated derivatives
ISX45_RS01325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISX45_RS01330	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ISX45_RS01335	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS01340	COG0646	methionine synthase
ISX45_RS01340	COG1410	methionine synthase
ISX45_RS01345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISX45_RS01345	COG0646	methionine synthase
ISX45_RS01350	COG1666	GTP binding
ISX45_RS01355	COG2996	Protein conserved in bacteria
ISX45_RS01360	COG1744	ABC transporter substrate-binding protein PnrA-like
ISX45_RS01365	COG0840	transmembrane signaling receptor activity
ISX45_RS01375	COG1307	EDD domain protein, DegV family
ISX45_RS01380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_RS01395	COG0561	phosphatase activity
ISX45_RS01400	COG1073	alpha beta
ISX45_RS01410	COG0746	molybdenum cofactor guanylyltransferase activity
ISX45_RS01415	COG4149	molybdate abc transporter
ISX45_RS01420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISX45_RS01425	COG0303	'Molybdopterin
ISX45_RS01435	COG0314	molybdopterin synthase activity
ISX45_RS01440	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISX45_RS01455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISX45_RS01460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ISX45_RS01465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISX45_RS01485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISX45_RS01495	COG0542	response to heat
ISX45_RS01505	COG2267	carboxylic ester hydrolase activity
ISX45_RS01515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX45_RS01520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISX45_RS01525	COG5504	Zn-dependent protease
ISX45_RS01545	COG4166	transmembrane transport
ISX45_RS01550	COG0601	transmembrane transport
ISX45_RS01555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX45_RS01560	COG0444	Belongs to the ABC transporter superfamily
ISX45_RS01565	COG4608	Belongs to the ABC transporter superfamily
ISX45_RS01575	COG1393	Belongs to the ArsC family
ISX45_RS01580	COG0861	Integral membrane protein TerC family
ISX45_RS01590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISX45_RS01600	COG1164	Oligoendopeptidase f
ISX45_RS01610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISX45_RS01615	COG2346	COG2346, Truncated hemoglobins
ISX45_RS01620	COG0741	lytic transglycosylase activity
ISX45_RS01625	COG4116	CYTH
ISX45_RS01635	COG2357	RelA SpoT domain protein
ISX45_RS01645	COG0564	pseudouridine synthase activity
ISX45_RS01650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISX45_RS01655	COG0772	Belongs to the SEDS family
ISX45_RS01660	COG2239	Acts as a magnesium transporter
ISX45_RS01685	COG0438	transferase activity, transferring glycosyl groups
ISX45_RS01690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISX45_RS01695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ISX45_RS01700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISX45_RS01755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX45_RS01770	COG2323	membrane
ISX45_RS01780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_RS01805	COG2153	protein acetylation
ISX45_RS01810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISX45_RS01815	COG2382	esterase
ISX45_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS01830	COG0626	cystathionine gamma-synthase activity
ISX45_RS01835	COG0626	cystathionine gamma-synthase activity
ISX45_RS01840	COG1418	mRNA catabolic process
ISX45_RS01845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISX45_RS01905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX45_RS01910	COG3162	membrane
ISX45_RS01915	COG0531	amino acid
ISX45_RS01920	COG1191	sigma factor activity
ISX45_RS01940	COG1609	Transcriptional regulator
ISX45_RS01950	COG2814	Major facilitator Superfamily
ISX45_RS01955	COG1063	alcohol dehydrogenase
ISX45_RS01985	COG5002	protein histidine kinase activity
ISX45_RS01990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISX45_RS02000	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISX45_RS02005	COG1129	ABC transporter
ISX45_RS02010	COG1879	ABC-type sugar transport system periplasmic component
ISX45_RS02015	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISX45_RS02020	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ISX45_RS02025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISX45_RS02030	COG0436	Aminotransferase
ISX45_RS02035	COG1850	ribulose-bisphosphate carboxylase activity
ISX45_RS02040	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISX45_RS02045	COG0235	Class ii aldolase
ISX45_RS02050	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISX45_RS02065	COG1846	Transcriptional regulator
ISX45_RS02070	COG4869	propanediol catabolic process
ISX45_RS02075	COG0531	amino acid
ISX45_RS02085	COG1051	belongs to the nudix hydrolase family
ISX45_RS02095	COG1131	(ABC) transporter
ISX45_RS02110	COG0542	response to heat
ISX45_RS02120	COG3949	Membrane
ISX45_RS02145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISX45_RS02150	COG0720	synthase
ISX45_RS02170	COG0702	epimerase
ISX45_RS02175	COG4873	Protein conserved in bacteria
ISX45_RS02180	COG3773	Cell wall hydrolase
ISX45_RS02205	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS02225	COG5002	protein histidine kinase activity
ISX45_RS02230	COG0778	Nitroreductase
ISX45_RS02245	COG0475	glutathione-regulated potassium exporter activity
ISX45_RS02255	COG0596	Alpha beta hydrolase
ISX45_RS02265	COG0561	phosphatase activity
ISX45_RS02270	COG3711	transcriptional antiterminator
ISX45_RS02275	COG1263	PTS System
ISX45_RS02275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX45_RS02275	COG2190	(PTS) system
ISX45_RS02300	COG0840	transmembrane signaling receptor activity
ISX45_RS02310	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS02315	COG2314	TM2 domain
ISX45_RS02320	COG2084	Dehydrogenase
ISX45_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS02340	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_RS02360	COG0436	Aminotransferase
ISX45_RS02370	COG0598	Magnesium transport protein CorA
ISX45_RS02380	COG2814	Major facilitator Superfamily
ISX45_RS02400	COG0835	chemotaxis
ISX45_RS02400	COG0784	Response regulator, receiver
ISX45_RS02430	COG1408	metallophosphoesterase
ISX45_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS02440	COG4990	cell redox homeostasis
ISX45_RS02445	COG2200	EAL domain
ISX45_RS02470	COG0517	IMP dehydrogenase activity
ISX45_RS02480	COG0583	DNA-binding transcription factor activity
ISX45_RS02485	COG2171	N-acyltransferase activity
ISX45_RS02490	COG1473	amidohydrolase
ISX45_RS02500	COG0668	transmembrane transport
ISX45_RS02505	COG0450	alkyl hydroperoxide reductase
ISX45_RS02510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_RS02525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ISX45_RS02530	COG5503	Protein of unknown function (DUF1447)
ISX45_RS02535	COG0561	phosphatase activity
ISX45_RS02590	COG1280	lysine exporter protein (LysE YggA)
ISX45_RS02595	COG1982	Orn Lys Arg decarboxylase major
ISX45_RS02605	COG4476	Belongs to the UPF0223 family
ISX45_RS02615	COG0483	inositol monophosphate 1-phosphatase activity
ISX45_RS02625	COG1217	gtp-binding protein TYPA
ISX45_RS02640	COG4896	Protein conserved in bacteria
ISX45_RS02655	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISX45_RS02660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISX45_RS02665	COG4838	Belongs to the UPF0358 family
ISX45_RS02670	COG0772	Belongs to the SEDS family
ISX45_RS02675	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ISX45_RS02680	COG1612	heme a metabolic process
ISX45_RS02685	COG0109	protoheme IX farnesyltransferase activity
ISX45_RS02710	COG3336	cytochrome c oxidase
ISX45_RS02730	COG2340	Cysteine-rich secretory protein family
ISX45_RS02735	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ISX45_RS02740	COG2340	Cysteine-rich secretory protein family
ISX45_RS02760	COG3679	Belongs to the UPF0342 family
ISX45_RS02765	COG4471	UPF0298 protein
ISX45_RS02785	COG0742	ribosomal rna small subunit methyltransferase
ISX45_RS02790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ISX45_RS02795	COG3314	Sporulation integral membrane protein YlbJ
ISX45_RS02800	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISX45_RS02805	COG3480	Lon protease (S16) C-terminal proteolytic domain
ISX45_RS02810	COG1323	Belongs to the UPF0348 family
ISX45_RS02815	COG1399	metal-binding, possibly nucleic acid-binding protein
ISX45_RS02820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISX45_RS02825	COG1024	Enoyl-CoA hydratase
ISX45_RS02835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISX45_RS02845	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ISX45_RS02850	COG0275	rRNA processing
ISX45_RS02860	COG0768	penicillin binding
ISX45_RS02865	COG0768	penicillin binding
ISX45_RS02870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISX45_RS02880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISX45_RS02885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ISX45_RS02890	COG0772	Belongs to the SEDS family
ISX45_RS02895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISX45_RS02900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISX45_RS02905	COG3879	Bacterial protein of unknown function (DUF881)
ISX45_RS02910	COG3879	Bacterial protein of unknown function (DUF881)
ISX45_RS02915	COG3856	small basic protein
ISX45_RS02920	COG0849	cell division
ISX45_RS02925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISX45_RS02935	COG1191	sigma factor activity
ISX45_RS02940	COG1191	sigma factor activity
ISX45_RS02945	COG1873	PFAM PRC-barrel domain
ISX45_RS02955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISX45_RS02960	COG1799	cell septum assembly
ISX45_RS02965	COG0762	integral membrane protein
ISX45_RS02970	COG2302	S4 RNA-binding domain
ISX45_RS02975	COG3599	regulation of cell shape
ISX45_RS02980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ISX45_RS02985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ISX45_RS02990	COG0564	pseudouridine synthase activity
ISX45_RS02995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ISX45_RS03005	COG0540	Belongs to the ATCase OTCase family
ISX45_RS03010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISX45_RS03025	COG0543	2 iron, 2 sulfur cluster binding
ISX45_RS03030	COG0167	dihydroorotate dehydrogenase activity
ISX45_RS03035	COG0284	orotidine-5'-phosphate decarboxylase activity
ISX45_RS03050	COG1136	(ABC) transporter
ISX45_RS03050	COG0577	efflux transmembrane transporter activity
ISX45_RS03055	COG0577	efflux transmembrane transporter activity
ISX45_RS03055	COG1136	(ABC) transporter
ISX45_RS03065	COG5002	protein histidine kinase activity
ISX45_RS03075	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ISX45_RS03080	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ISX45_RS03085	COG1561	YicC-like family, N-terminal region
ISX45_RS03090	COG2052	Domain of unknown function (DUF370)
ISX45_RS03095	COG0194	GDP metabolic process
ISX45_RS03100	COG1758	RNA polymerase activity
ISX45_RS03105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISX45_RS03110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISX45_RS03115	COG0242	peptide deformylase activity
ISX45_RS03120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISX45_RS03125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISX45_RS03125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISX45_RS03130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISX45_RS03135	COG0631	protein serine/threonine phosphatase activity
ISX45_RS03140	COG2815	serine threonine protein kinase
ISX45_RS03140	COG0515	serine threonine protein kinase
ISX45_RS03145	COG1162	GTPase activity
ISX45_RS03150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISX45_RS03155	COG1564	THIamine pyrophosphokinase
ISX45_RS03165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ISX45_RS03170	COG1302	Protein conserved in bacteria
ISX45_RS03175	COG1461	Dihydroxyacetone kinase
ISX45_RS03180	COG1760	l-serine dehydratase
ISX45_RS03185	COG1760	l-serine dehydratase
ISX45_RS03190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISX45_RS03195	COG1349	DNA-binding transcription factor activity
ISX45_RS03200	COG0416	fatty acid biosynthetic process
ISX45_RS03205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISX45_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS03215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISX45_RS03220	COG0571	ribonuclease III activity
ISX45_RS03225	COG1196	nuclear chromosome segregation
ISX45_RS03230	COG0552	protein localization to endoplasmic reticulum
ISX45_RS03235	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ISX45_RS03240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISX45_RS03245	COG0228	four-way junction DNA binding
ISX45_RS03250	COG1837	Belongs to the UPF0109 family
ISX45_RS03260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISX45_RS03265	COG0336	Belongs to the RNA methyltransferase TrmD family
ISX45_RS03270	COG0335	large ribosomal subunit rRNA binding
ISX45_RS03280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ISX45_RS03285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ISX45_RS03295	COG2257	FlhB HrpN YscU SpaS Family
ISX45_RS03300	COG0045	succinate-CoA ligase (ADP-forming) activity
ISX45_RS03305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISX45_RS03310	COG0758	DNA mediated transformation
ISX45_RS03315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISX45_RS03320	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ISX45_RS03325	COG4974	Belongs to the 'phage' integrase family
ISX45_RS03330	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ISX45_RS03335	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISX45_RS03340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ISX45_RS03345	COG1815	bacterial-type flagellum-dependent cell motility
ISX45_RS03350	COG1558	bacterial-type flagellum-dependent cell motility
ISX45_RS03355	COG1677	Flagellar hook-basal body complex protein FliE
ISX45_RS03360	COG1766	The M ring may be actively involved in energy transduction
ISX45_RS03365	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ISX45_RS03370	COG1317	bacterial-type flagellum organization
ISX45_RS03375	COG1157	protein secretion by the type III secretion system
ISX45_RS03380	COG2882	bacterial-type flagellum organization
ISX45_RS03390	COG3144	bacterial-type flagellum assembly
ISX45_RS03395	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISX45_RS03400	COG4786	Flagellar basal body rod
ISX45_RS03405	COG1582	Flagellar protein (FlbD)
ISX45_RS03415	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ISX45_RS03420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ISX45_RS03420	COG1776	CheC inhibitor of MCP methylation
ISX45_RS03425	COG2201	protein-glutamate methylesterase activity
ISX45_RS03430	COG3190	flagellar
ISX45_RS03435	COG1338	Plays a role in the flagellum-specific transport system
ISX45_RS03440	COG1987	bacterial-type flagellum assembly
ISX45_RS03445	COG1684	flagellar biosynthetic protein fliR
ISX45_RS03450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISX45_RS03455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISX45_RS03460	COG1419	protein localization to endoplasmic reticulum
ISX45_RS03465	COG0455	bacterial-type flagellum organization
ISX45_RS03470	COG2201	protein-glutamate methylesterase activity
ISX45_RS03475	COG2198	Histidine kinase
ISX45_RS03475	COG0643	Histidine kinase
ISX45_RS03480	COG0835	chemotaxis
ISX45_RS03485	COG1776	CheC inhibitor of MCP methylation
ISX45_RS03490	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ISX45_RS03500	COG1191	sigma factor activity
ISX45_RS03515	COG0052	Belongs to the universal ribosomal protein uS2 family
ISX45_RS03520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISX45_RS03525	COG0528	UMP kinase activity
ISX45_RS03530	COG0233	cytoplasmic translational termination
ISX45_RS03535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISX45_RS03540	COG4589	Belongs to the CDS family
ISX45_RS03545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISX45_RS03550	COG0750	zinc metalloprotease
ISX45_RS03555	COG0442	prolyl-tRNA aminoacylation
ISX45_RS03560	COG2176	DNA-directed DNA polymerase activity
ISX45_RS03565	COG0779	Required for maturation of 30S ribosomal subunits
ISX45_RS03570	COG0195	Participates in both transcription termination and antitermination
ISX45_RS03575	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ISX45_RS03580	COG1358	cellular component organization or biogenesis
ISX45_RS03585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ISX45_RS03590	COG1550	Protein conserved in bacteria
ISX45_RS03595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ISX45_RS03600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ISX45_RS03605	COG0196	riboflavin kinase activity
ISX45_RS03610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ISX45_RS03615	COG1185	polyribonucleotide nucleotidyltransferase activity
ISX45_RS03620	COG0726	polysaccharide deacetylase
ISX45_RS03625	COG0612	Peptidase, M16
ISX45_RS03630	COG1873	PFAM PRC-barrel domain
ISX45_RS03635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISX45_RS03640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISX45_RS03645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISX45_RS03650	COG0527	aspartate kinase activity
ISX45_RS03660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ISX45_RS03665	COG0740	serine-type endopeptidase activity
ISX45_RS03675	COG4980	gas vesicle protein
ISX45_RS03675	COG1674	ftsk spoiiie
ISX45_RS03680	COG2188	Transcriptional regulator
ISX45_RS03685	COG1744	ABC transporter substrate-binding protein PnrA-like
ISX45_RS03690	COG3845	ABC transporter
ISX45_RS03695	COG4603	Belongs to the binding-protein-dependent transport system permease family
ISX45_RS03700	COG1079	Belongs to the binding-protein-dependent transport system permease family
ISX45_RS03705	COG0612	Peptidase, M16
ISX45_RS03710	COG0612	Peptidase, M16
ISX45_RS03715	COG0300	oxidoreductase activity
ISX45_RS03730	COG1426	Protein conserved in bacteria
ISX45_RS03735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISX45_RS03740	COG1058	Belongs to the CinA family
ISX45_RS03740	COG1546	Belongs to the CinA family
ISX45_RS03755	COG1418	mRNA catabolic process
ISX45_RS03760	COG1692	metallophosphoesterase
ISX45_RS03765	COG2359	stage V sporulation protein S
ISX45_RS03775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISX45_RS03775	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISX45_RS03780	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISX45_RS03785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISX45_RS03790	COG4550	Control of competence regulator ComK, YlbF/YmcA
ISX45_RS03800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISX45_RS03805	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISX45_RS03810	COG2855	membrane
ISX45_RS03820	COG1280	lysine exporter protein (LysE YggA)
ISX45_RS03840	COG1404	Belongs to the peptidase S8 family
ISX45_RS03855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_RS03885	COG0789	Transcriptional regulator
ISX45_RS03890	COG1664	Polymer-forming cytoskeletal
ISX45_RS03895	COG1664	Polymer-forming cytoskeletal
ISX45_RS03900	COG2814	Major facilitator Superfamily
ISX45_RS03905	COG0477	Major facilitator Superfamily
ISX45_RS03915	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISX45_RS03920	COG1923	regulation of RNA biosynthetic process
ISX45_RS03925	COG0464	growth
ISX45_RS03935	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS03940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ISX45_RS03970	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_RS03975	COG0183	Belongs to the thiolase family
ISX45_RS03980	COG2860	membrane
ISX45_RS03985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISX45_RS03990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ISX45_RS03995	COG0789	Transcriptional regulator
ISX45_RS04000	COG0174	glutamine synthetase
ISX45_RS04005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISX45_RS04010	COG1388	LysM domain
ISX45_RS04015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ISX45_RS04020	COG4224	UPF0291 protein
ISX45_RS04035	COG3763	UPF0154 protein
ISX45_RS04040	COG1132	(ABC) transporter
ISX45_RS04045	COG1132	(ABC) transporter
ISX45_RS04055	COG0785	Cytochrome C biogenesis protein
ISX45_RS04060	COG2201	protein-glutamate methylesterase activity
ISX45_RS04065	COG4846	Membrane protein involved in cytochrome C biogenesis
ISX45_RS04075	COG3773	Cell wall hydrolase
ISX45_RS04080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISX45_RS04080	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ISX45_RS04100	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISX45_RS04105	COG1486	melibiose metabolic process
ISX45_RS04130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISX45_RS04155	COG0328	RNA-DNA hybrid ribonuclease activity
ISX45_RS04165	COG0328	RNA-DNA hybrid ribonuclease activity
ISX45_RS04195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISX45_RS04200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISX45_RS04205	COG5001	Diguanylate cyclase
ISX45_RS04205	COG3300	MHYT domain
ISX45_RS04215	COG4608	Belongs to the ABC transporter superfamily
ISX45_RS04220	COG0601	transmembrane transport
ISX45_RS04230	COG0747	negative chemotaxis
ISX45_RS04240	COG0346	lactoylglutathione lyase activity
ISX45_RS04245	COG3180	Ammonia monooxygenase
ISX45_RS04300	COG3711	transcriptional antiterminator
ISX45_RS04310	COG3037	sugar-specific permease SgaT UlaA
ISX45_RS04315	COG0582	viral genome integration into host DNA
ISX45_RS04335	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISX45_RS04380	COG1114	Component of the transport system for branched-chain amino acids
ISX45_RS04395	COG3335	DDE superfamily endonuclease
ISX45_RS04400	COG1136	(ABC) transporter
ISX45_RS04405	COG0577	efflux transmembrane transporter activity
ISX45_RS04475	COG0531	amino acid
ISX45_RS04485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX45_RS04495	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ISX45_RS04500	COG0367	asparagine synthase
ISX45_RS04520	COG1113	amino acid transport
ISX45_RS04525	COG1349	DNA-binding transcription factor activity
ISX45_RS04530	COG3395	kinase activity
ISX45_RS04535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISX45_RS04545	COG1376	ErfK ybiS ycfS ynhG family protein
ISX45_RS04555	COG2819	hydrolase of the alpha beta superfamily
ISX45_RS04560	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS04565	COG1169	isochorismate synthase
ISX45_RS04570	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISX45_RS04575	COG1535	isochorismatase
ISX45_RS04575	COG3433	isochorismatase activity
ISX45_RS04580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISX45_RS04585	COG3251	PFAM MbtH domain protein
ISX45_RS04600	COG0791	NLP P60 protein
ISX45_RS04600	COG1388	LysM domain
ISX45_RS04620	COG3414	Phosphotransferase system galactitol-specific IIB component
ISX45_RS04625	COG3775	system Galactitol-specific IIC component
ISX45_RS04630	COG1063	alcohol dehydrogenase
ISX45_RS04640	COG1063	alcohol dehydrogenase
ISX45_RS04645	COG0583	DNA-binding transcription factor activity
ISX45_RS04650	COG0067	glutamate synthase
ISX45_RS04650	COG0069	glutamate synthase activity
ISX45_RS04650	COG0070	glutamate synthase
ISX45_RS04655	COG0493	'glutamate synthase
ISX45_RS04670	COG1126	abc transporter atp-binding protein
ISX45_RS04675	COG0765	amino acid transport
ISX45_RS04680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX45_RS04685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISX45_RS04695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISX45_RS04700	COG1388	LysM domain
ISX45_RS04700	COG3858	chitin binding
ISX45_RS04730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX45_RS04735	COG4521	taurine ABC transporter
ISX45_RS04745	COG2175	clavaminate synthase activity
ISX45_RS04750	COG2076	Multidrug Resistance protein
ISX45_RS04755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_RS04765	COG3829	transcription factor binding
ISX45_RS04765	COG3290	protein histidine kinase activity
ISX45_RS04770	COG2376	Dihydroxyacetone kinase
ISX45_RS04780	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ISX45_RS04785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_RS04790	COG3284	Transcriptional regulator
ISX45_RS04795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISX45_RS04800	COG0022	dehydrogenase e1 component
ISX45_RS04805	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISX45_RS04850	COG2508	Transcriptional regulator
ISX45_RS04855	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS04860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISX45_RS04885	COG2116	formate transmembrane transporter activity
ISX45_RS04895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISX45_RS04900	COG0693	protein deglycase activity
ISX45_RS04915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISX45_RS04925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISX45_RS04930	COG0438	transferase activity, transferring glycosyl groups
ISX45_RS04965	COG1657	PFAM Prenyltransferase squalene oxidase
ISX45_RS04975	COG1737	Transcriptional regulator
ISX45_RS04980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_RS04980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_RS04980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_RS04985	COG0383	alpha-mannosidase activity
ISX45_RS05000	COG1737	Transcriptional regulator
ISX45_RS05005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ISX45_RS05010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX45_RS05010	COG1263	PTS System
ISX45_RS05020	COG0667	Aldo Keto reductase
ISX45_RS05030	COG3711	transcriptional antiterminator
ISX45_RS05060	COG3290	protein histidine kinase activity
ISX45_RS05065	COG4565	transcriptional regulatory protein
ISX45_RS05075	COG0840	transmembrane signaling receptor activity
ISX45_RS05080	COG1609	Transcriptional regulator
ISX45_RS05085	COG1070	Carbohydrate kinase
ISX45_RS05095	COG0456	acetyltransferase
ISX45_RS05100	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISX45_RS05115	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS05130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISX45_RS05135	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS05140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISX45_RS05150	COG1024	Enoyl-CoA hydratase
ISX45_RS05155	COG0402	S-adenosylhomocysteine deaminase activity
ISX45_RS05160	COG1522	sequence-specific DNA binding
ISX45_RS05165	COG2362	D-Aminopeptidase
ISX45_RS05170	COG0601	transmembrane transport
ISX45_RS05175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX45_RS05180	COG0444	Belongs to the ABC transporter superfamily
ISX45_RS05185	COG4608	Belongs to the ABC transporter superfamily
ISX45_RS05190	COG4166	transmembrane transport
ISX45_RS05200	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ISX45_RS05215	COG2070	2-Nitropropane dioxygenase
ISX45_RS05220	COG4213	ABC transporter substrate-binding protein
ISX45_RS05230	COG4214	carbohydrate transport
ISX45_RS05245	COG1069	ribulokinase activity
ISX45_RS05250	COG2160	L-arabinose isomerase activity
ISX45_RS05285	COG4213	ABC transporter substrate-binding protein
ISX45_RS05290	COG1129	ABC transporter
ISX45_RS05295	COG4214	carbohydrate transport
ISX45_RS05310	COG1070	Carbohydrate kinase
ISX45_RS05315	COG0628	permease
ISX45_RS05320	COG3290	protein histidine kinase activity
ISX45_RS05320	COG3829	transcription factor binding
ISX45_RS05335	COG1454	alcohol dehydrogenase
ISX45_RS05355	COG0789	Transcriptional regulator
ISX45_RS05360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISX45_RS05365	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISX45_RS05370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISX45_RS05375	COG2723	6-phospho-beta-galactosidase activity
ISX45_RS05380	COG2188	Transcriptional regulator
ISX45_RS05390	COG0726	polysaccharide deacetylase
ISX45_RS05395	COG1408	metallophosphoesterase
ISX45_RS05400	COG1757	Na H antiporter
ISX45_RS05450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISX45_RS05450	COG2199	diguanylate cyclase activity
ISX45_RS05455	COG0456	acetyltransferase
ISX45_RS05460	COG1349	DNA-binding transcription factor activity
ISX45_RS05465	COG1105	Belongs to the carbohydrate kinase PfkB family
ISX45_RS05470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_RS05470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_RS05470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_RS05475	COG0701	Predicted permease
ISX45_RS05480	COG3689	TIGRFAM TIGR03943 family protein
ISX45_RS05485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISX45_RS05490	COG0432	Pfam Uncharacterised protein family UPF0047
ISX45_RS05510	COG5002	protein histidine kinase activity
ISX45_RS05520	COG1587	Uroporphyrinogen-III synthase
ISX45_RS05535	COG0706	membrane insertase activity
ISX45_RS05540	COG1164	Oligoendopeptidase f
ISX45_RS05545	COG4989	oxidoreductase activity
ISX45_RS05550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISX45_RS05575	COG0456	acetyltransferase
ISX45_RS05600	COG0310	cobalt ion transport
ISX45_RS05605	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
ISX45_RS05615	COG1122	ATPase activity
ISX45_RS05640	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ISX45_RS05670	COG1492	cobalamin metabolic process
ISX45_RS05675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ISX45_RS05685	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ISX45_RS05690	COG2226	methyltransferase
ISX45_RS05700	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISX45_RS05715	COG0386	Belongs to the glutathione peroxidase family
ISX45_RS05720	COG1418	mRNA catabolic process
ISX45_RS05725	COG0488	(ABC) transporter
ISX45_RS05730	COG1413	lyase activity
ISX45_RS05740	COG2521	methyltransferase
ISX45_RS05740	COG2136	Putative SAM-dependent methyltransferase
ISX45_RS05750	COG0436	Aminotransferase
ISX45_RS05760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ISX45_RS05765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISX45_RS05775	COG1272	protein, Hemolysin III
ISX45_RS05785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISX45_RS05795	COG1307	EDD domain protein, DegV family
ISX45_RS05800	COG1999	signal sequence binding
ISX45_RS05805	COG2755	lipolytic protein G-D-S-L family
ISX45_RS05815	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ISX45_RS05815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISX45_RS05820	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ISX45_RS05825	COG0277	FAD linked oxidase domain protein
ISX45_RS05830	COG0247	lactate metabolic process
ISX45_RS05835	COG0277	FAD linked oxidase domain protein
ISX45_RS05840	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISX45_RS05845	COG0281	malic enzyme
ISX45_RS05850	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISX45_RS05855	COG1414	Transcriptional regulator
ISX45_RS05860	COG1765	OsmC-like protein
ISX45_RS05875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_RS05880	COG1525	nuclease
ISX45_RS05880	COG4085	toxin activity
ISX45_RS05880	COG0737	Belongs to the 5'-nucleotidase family
ISX45_RS05885	COG1271	oxidase subunit
ISX45_RS05890	COG1294	oxidase, subunit
ISX45_RS05895	COG4988	ABC transporter
ISX45_RS05900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISX45_RS05910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX45_RS05930	COG3647	Membrane
ISX45_RS05935	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ISX45_RS06005	COG0456	acetyltransferase
ISX45_RS06010	COG0384	phenazine biosynthesis protein PhzF
ISX45_RS06045	COG1331	Highly conserved protein containing a thioredoxin domain
ISX45_RS06050	COG1331	Highly conserved protein containing a thioredoxin domain
ISX45_RS06055	COG1832	CoA-binding protein
ISX45_RS06060	COG0187	DNA topoisomerase II activity
ISX45_RS06065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISX45_RS06080	COG1263	PTS System
ISX45_RS06080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX45_RS06085	COG0366	Alpha amylase catalytic
ISX45_RS06090	COG2188	Transcriptional regulator
ISX45_RS06095	COG1757	Na H antiporter
ISX45_RS06100	COG0824	Thioesterase
ISX45_RS06110	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS06115	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ISX45_RS06120	COG1959	2 iron, 2 sulfur cluster binding
ISX45_RS06125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISX45_RS06125	COG1017	nitric oxide dioxygenase activity
ISX45_RS06130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISX45_RS06130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISX45_RS06135	COG0788	formyltetrahydrofolate deformylase activity
ISX45_RS06145	COG0714	Associated with various cellular activities
ISX45_RS06150	COG4548	von Willebrand factor, type A
ISX45_RS06155	COG2404	hydrolase activity, acting on ester bonds
ISX45_RS06175	COG1309	transcriptional regulator
ISX45_RS06180	COG0109	protoheme IX farnesyltransferase activity
ISX45_RS06250	COG1611	Belongs to the LOG family
ISX45_RS06255	COG0167	dihydroorotate dehydrogenase activity
ISX45_RS06260	COG3238	Protein conserved in bacteria
ISX45_RS06280	COG1051	belongs to the nudix hydrolase family
ISX45_RS06285	COG2368	4-hydroxyphenylacetate
ISX45_RS06295	COG2226	methyltransferase
ISX45_RS06305	COG2211	Major facilitator Superfamily
ISX45_RS06325	COG3340	Belongs to the peptidase S51 family
ISX45_RS06340	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS06345	COG0583	DNA-binding transcription factor activity
ISX45_RS06365	COG5634	Uncharacterized conserved protein (DUF2278)
ISX45_RS06390	COG1132	(ABC) transporter
ISX45_RS06395	COG1132	(ABC) transporter
ISX45_RS06460	COG0604	alcohol dehydrogenase
ISX45_RS06470	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISX45_RS06475	COG0567	Dehydrogenase, E1 component
ISX45_RS06490	COG0531	amino acid
ISX45_RS06495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISX45_RS06500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISX45_RS06505	COG0640	Transcriptional regulator
ISX45_RS06520	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_RS06525	COG1309	transcriptional regulator
ISX45_RS06530	COG0183	Belongs to the thiolase family
ISX45_RS06540	COG2030	dehydratase
ISX45_RS06550	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS06555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISX45_RS06565	COG0840	transmembrane signaling receptor activity
ISX45_RS06585	COG0531	amino acid
ISX45_RS06595	COG0531	amino acid
ISX45_RS06600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISX45_RS06625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISX45_RS06630	COG0640	Transcriptional regulator
ISX45_RS06635	COG1522	sequence-specific DNA binding
ISX45_RS06635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX45_RS06640	COG2313	pseudouridylate synthase activity
ISX45_RS06650	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISX45_RS06665	COG0778	Nitroreductase
ISX45_RS06675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ISX45_RS06695	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ISX45_RS06700	COG1131	(ABC) transporter
ISX45_RS06720	COG4682	membrane
ISX45_RS06725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX45_RS06730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISX45_RS06735	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ISX45_RS06740	COG1609	Transcriptional regulator
ISX45_RS06755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX45_RS06770	COG0730	response to heat
ISX45_RS06780	COG0390	transport system, permease component
ISX45_RS06795	COG1278	Cold shock
ISX45_RS06810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_RS06815	COG2258	MOSC domain
ISX45_RS06820	COG1132	(ABC) transporter
ISX45_RS06825	COG1132	(ABC) transporter
ISX45_RS06830	COG1366	Belongs to the anti-sigma-factor antagonist family
ISX45_RS06840	COG2208	phosphoserine phosphatase activity
ISX45_RS06845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISX45_RS06855	COG0697	spore germination
ISX45_RS06880	COG1131	(ABC) transporter
ISX45_RS06885	COG1725	Transcriptional regulator
ISX45_RS06890	COG2205	protein histidine kinase activity
ISX45_RS06895	COG2323	membrane
ISX45_RS06900	COG0697	spore germination
ISX45_RS06905	COG0697	spore germination
ISX45_RS06925	COG2223	nitrite transmembrane transporter activity
ISX45_RS06945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX45_RS06950	COG2814	Major facilitator Superfamily
ISX45_RS06955	COG1566	PFAM secretion protein HlyD family protein
ISX45_RS06970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISX45_RS06975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISX45_RS06980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISX45_RS06985	COG1024	Enoyl-CoA hydratase
ISX45_RS06990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISX45_RS06995	COG0511	ligase activity, forming carbon-carbon bonds
ISX45_RS07000	COG0439	Biotin carboxylase
ISX45_RS07005	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_RS07010	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS07015	COG1309	transcriptional regulator
ISX45_RS07020	COG0655	NAD(P)H dehydrogenase (quinone) activity
ISX45_RS07055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISX45_RS07060	COG2211	Major facilitator Superfamily
ISX45_RS07070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ISX45_RS07075	COG0084	hydrolase, TatD family'
ISX45_RS07080	COG3852	Histidine kinase
ISX45_RS07085	COG0534	Mate efflux family protein
ISX45_RS07115	COG3655	Transcriptional regulator
ISX45_RS07120	COG3739	integral membrane protein
ISX45_RS07130	COG2962	Rard protein
ISX45_RS07145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_RS07150	COG0450	alkyl hydroperoxide reductase
ISX45_RS07155	COG0598	Magnesium transport protein CorA
ISX45_RS07160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISX45_RS07165	COG2226	methyltransferase
ISX45_RS07175	COG1876	peptidase activity
ISX45_RS07180	COG0813	purine-nucleoside phosphorylase activity
ISX45_RS07210	COG4326	sporulation control protein
ISX45_RS07215	COG0515	serine threonine protein kinase
ISX45_RS07215	COG1357	PFAM Pentapeptide repeats (8 copies)
ISX45_RS07245	COG4479	Belongs to the UPF0346 family
ISX45_RS07255	COG1509	lysine 2,3-aminomutase activity
ISX45_RS07260	COG0456	acetyltransferase
ISX45_RS07265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISX45_RS07270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISX45_RS07275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISX45_RS07280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISX45_RS07285	COG0492	ferredoxin-NADP+ reductase activity
ISX45_RS07290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISX45_RS07315	COG4841	protein insertion into membrane
ISX45_RS07320	COG2050	protein possibly involved in aromatic compounds catabolism
ISX45_RS07330	COG0824	Thioesterase
ISX45_RS07350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_RS07375	COG3541	Predicted nucleotidyltransferase
ISX45_RS07380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ISX45_RS07385	COG1755	Isoprenylcysteine carboxyl methyltransferase
ISX45_RS07390	COG3424	synthase
ISX45_RS07395	COG2233	PERMEase
ISX45_RS07400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISX45_RS07410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISX45_RS07415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISX45_RS07420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISX45_RS07425	COG1199	ATP-dependent helicase activity
ISX45_RS07435	COG0116	Belongs to the methyltransferase superfamily
ISX45_RS07445	COG3599	regulation of cell shape
ISX45_RS07450	COG4474	Belongs to the UPF0398 family
ISX45_RS07460	COG3359	exonuclease
ISX45_RS07465	COG1111	helicase
ISX45_RS07465	COG1205	dead DEAH box helicase
ISX45_RS07470	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS07480	COG1131	(ABC) transporter
ISX45_RS07490	COG0670	Belongs to the BI1 family
ISX45_RS07495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISX45_RS07505	COG5002	protein histidine kinase activity
ISX45_RS07510	COG0745	RESPONSE REGULATOR receiver
ISX45_RS07520	COG3852	Histidine kinase
ISX45_RS07550	COG3104	oligopeptide transport
ISX45_RS07560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_RS07565	COG0833	amino acid
ISX45_RS07570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISX45_RS07585	COG3594	Acyltransferase
ISX45_RS07590	COG0352	thiamine-phosphate diphosphorylase activity
ISX45_RS07595	COG0351	phosphomethylpyrimidine kinase
ISX45_RS07600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ISX45_RS07605	COG0463	Glycosyl transferase, family 2
ISX45_RS07615	COG2226	methyltransferase
ISX45_RS07630	COG3383	formate dehydrogenase (NAD+) activity
ISX45_RS07645	COG3832	glyoxalase III activity
ISX45_RS07650	COG0640	Transcriptional regulator
ISX45_RS07660	COG1914	H( )-stimulated, divalent metal cation uptake system
ISX45_RS07665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ISX45_RS07670	COG1984	allophanate hydrolase subunit 2
ISX45_RS07675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISX45_RS07680	COG1414	Transcriptional regulator
ISX45_RS07690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX45_RS07695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISX45_RS07695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISX45_RS07700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX45_RS07705	COG2011	ABC-type metal ion transport system permease component
ISX45_RS07710	COG1464	Belongs to the NlpA lipoprotein family
ISX45_RS07715	COG0371	Dehydrogenase
ISX45_RS07720	COG0133	tryptophan synthase activity
ISX45_RS07725	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISX45_RS07725	COG0456	acetyltransferase
ISX45_RS07755	COG0534	Mate efflux family protein
ISX45_RS07765	COG0444	Belongs to the ABC transporter superfamily
ISX45_RS07770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX45_RS07775	COG0601	transmembrane transport
ISX45_RS07780	COG0747	negative chemotaxis
ISX45_RS07785	COG3011	Protein conserved in bacteria
ISX45_RS07790	COG2135	peptidase activity
ISX45_RS07805	COG0569	domain protein
ISX45_RS07805	COG0475	glutathione-regulated potassium exporter activity
ISX45_RS07820	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS07825	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_RS07845	COG4555	ABC transporter
ISX45_RS07850	COG1120	ATPase activity
ISX45_RS07860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_RS07865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_RS07870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_RS07875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_RS07880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISX45_RS07900	COG1918	ferrous iron import across plasma membrane
ISX45_RS07900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ISX45_RS07905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ISX45_RS07910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ISX45_RS07920	COG1619	proteins homologs of microcin C7 resistance protein MccF
ISX45_RS07935	COG2002	toxin-antitoxin pair type II binding
ISX45_RS07960	COG3279	Response regulator of the LytR AlgR family
ISX45_RS07970	COG1847	R3H domain protein
ISX45_RS07995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISX45_RS08010	COG4221	oxidoreductase activity
ISX45_RS08025	COG0784	Response regulator, receiver
ISX45_RS08025	COG2198	Histidine kinase
ISX45_RS08025	COG5002	protein histidine kinase activity
ISX45_RS08060	COG2608	mercury ion transmembrane transporter activity
ISX45_RS08065	COG2217	Heavy metal translocating P-type atpase
ISX45_RS08070	COG1937	Protein conserved in bacteria
ISX45_RS08085	COG1120	ATPase activity
ISX45_RS08090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_RS08095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_RS08100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_RS08110	COG2176	DNA-directed DNA polymerase activity
ISX45_RS08120	COG0004	ammonium transporteR
ISX45_RS08125	COG0745	RESPONSE REGULATOR receiver
ISX45_RS08130	COG5002	protein histidine kinase activity
ISX45_RS08135	COG2132	Multicopper oxidase
ISX45_RS08160	COG3853	Toxic anion resistance protein (TelA)
ISX45_RS08205	COG0022	dehydrogenase e1 component
ISX45_RS08235	COG4120	Belongs to the binding-protein-dependent transport system permease family
ISX45_RS08255	COG3327	negative regulation of DNA-templated transcription, initiation
ISX45_RS08260	COG1024	Enoyl-CoA hydratase
ISX45_RS08265	COG0183	Belongs to the thiolase family
ISX45_RS08270	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_RS08275	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS08280	COG1024	Enoyl-CoA hydratase
ISX45_RS08285	COG1024	Enoyl-CoA hydratase
ISX45_RS08295	COG2151	metal-sulfur cluster biosynthetic enzyme
ISX45_RS08310	COG3396	Phenylacetate-CoA oxygenase
ISX45_RS08315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
ISX45_RS08325	COG0626	cystathionine gamma-synthase activity
ISX45_RS08330	COG0129	dihydroxy-acid dehydratase activity
ISX45_RS08335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ISX45_RS08340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISX45_RS08350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISX45_RS08355	COG2246	polysaccharide biosynthetic process
ISX45_RS08360	COG0463	Glycosyl transferase, family 2
ISX45_RS08365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISX45_RS08375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISX45_RS08385	COG5646	InterPro IPR014922
ISX45_RS08390	COG5646	InterPro IPR014922
ISX45_RS08395	COG3335	DDE superfamily endonuclease
ISX45_RS08405	COG0561	phosphatase activity
ISX45_RS08420	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS08425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_RS08430	COG1464	Belongs to the NlpA lipoprotein family
ISX45_RS08435	COG2011	ABC-type metal ion transport system permease component
ISX45_RS08440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX45_RS08445	COG1464	Belongs to the NlpA lipoprotein family
ISX45_RS08450	COG1473	amidohydrolase
ISX45_RS08460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISX45_RS08475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_RS08480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISX45_RS08485	COG0583	DNA-binding transcription factor activity
ISX45_RS08510	COG2066	Belongs to the glutaminase family
ISX45_RS08515	COG0156	8-amino-7-oxononanoate synthase activity
ISX45_RS08525	COG4377	Putative membrane peptidase family (DUF2324)
ISX45_RS08530	COG0346	lactoylglutathione lyase activity
ISX45_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS08555	COG1733	regulation of RNA biosynthetic process
ISX45_RS08560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISX45_RS08580	COG0671	phosphoesterase, PA-phosphatase related
ISX45_RS08585	COG2733	membrane
ISX45_RS08605	COG0477	Major facilitator Superfamily
ISX45_RS08605	COG2814	Major facilitator Superfamily
ISX45_RS08695	COG0071	Belongs to the small heat shock protein (HSP20) family
ISX45_RS08700	COG1609	Transcriptional regulator
ISX45_RS08705	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ISX45_RS08710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISX45_RS08715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ISX45_RS08720	COG2217	Heavy metal translocating P-type atpase
ISX45_RS08730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISX45_RS08735	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ISX45_RS08740	COG5002	protein histidine kinase activity
ISX45_RS08750	COG0071	Belongs to the small heat shock protein (HSP20) family
ISX45_RS08780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ISX45_RS08795	COG3331	DNA recombination
ISX45_RS08800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX45_RS08800	COG4499	WXG100 protein secretion system (Wss), protein YukC
ISX45_RS08810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISX45_RS08815	COG3935	DnaD domain protein
ISX45_RS08820	COG0017	Asparaginyl-tRNA synthetase
ISX45_RS08845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISX45_RS08845	COG1199	ATP-dependent helicase activity
ISX45_RS08850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ISX45_RS08855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ISX45_RS08860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISX45_RS08870	COG0617	tRNA 3'-terminal CCA addition
ISX45_RS08875	COG0438	transferase activity, transferring glycosyl groups
ISX45_RS08880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISX45_RS08885	COG1803	Methylglyoxal synthase
ISX45_RS08890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ISX45_RS08895	COG1694	Mazg nucleotide pyrophosphohydrolase
ISX45_RS08900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_RS08910	COG4347	Protein of unknown function (DUF1405)
ISX45_RS08920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISX45_RS08940	COG0457	Tetratricopeptide repeat
ISX45_RS08950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ISX45_RS08955	COG0287	Prephenate dehydrogenase
ISX45_RS08960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISX45_RS08965	COG0159	tryptophan synthase activity
ISX45_RS08970	COG0133	tryptophan synthase activity
ISX45_RS08975	COG0135	phosphoribosylanthranilate isomerase activity
ISX45_RS08980	COG0134	indole-3-glycerol-phosphate synthase activity
ISX45_RS08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISX45_RS08995	COG4401	Chorismate mutase type I
ISX45_RS09000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ISX45_RS09005	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ISX45_RS09010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISX45_RS09025	COG0105	UTP biosynthetic process
ISX45_RS09035	COG2226	methyltransferase
ISX45_RS09050	COG0302	gtp cyclohydrolase
ISX45_RS09060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ISX45_RS09075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISX45_RS09080	COG1160	GTP binding
ISX45_RS09110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ISX45_RS09115	COG0697	spore germination
ISX45_RS09120	COG1304	FMN binding
ISX45_RS09125	COG0539	negative regulation of cytoplasmic translation
ISX45_RS09135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISX45_RS09145	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ISX45_RS09150	COG2959	enzyme of heme biosynthesis
ISX45_RS09155	COG3773	Cell wall hydrolase
ISX45_RS09155	COG3409	Peptidoglycan-binding domain 1 protein
ISX45_RS09160	COG2339	peptidase activity
ISX45_RS09165	COG0252	asparaginase activity
ISX45_RS09170	COG0492	ferredoxin-NADP+ reductase activity
ISX45_RS09175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ISX45_RS09190	COG1408	metallophosphoesterase
ISX45_RS09210	COG3546	catalase activity
ISX45_RS09220	COG1733	regulation of RNA biosynthetic process
ISX45_RS09225	COG2814	Major facilitator Superfamily
ISX45_RS09230	COG0656	L-ascorbic acid biosynthetic process
ISX45_RS09245	COG1266	CAAX protease self-immunity
ISX45_RS09250	COG0514	ATP-dependent DNA helicase (RecQ)
ISX45_RS09255	COG4955	Helix-turn-helix domain
ISX45_RS09275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISX45_RS09280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ISX45_RS09290	COG1595	DNA-templated transcription, initiation
ISX45_RS09305	COG2096	Adenosyltransferase
ISX45_RS09320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ISX45_RS09325	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
ISX45_RS09330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISX45_RS09335	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ISX45_RS09340	COG1120	ATPase activity
ISX45_RS09345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_RS09350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_RS09380	COG2190	(PTS) system
ISX45_RS09380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISX45_RS09380	COG1263	PTS System
ISX45_RS09385	COG2188	Transcriptional regulator
ISX45_RS09390	COG0363	glucosamine-6-phosphate deaminase activity
ISX45_RS09395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISX45_RS09400	COG4821	SIS domain
ISX45_RS09405	COG5002	protein histidine kinase activity
ISX45_RS09410	COG0745	RESPONSE REGULATOR receiver
ISX45_RS09415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISX45_RS09420	COG1333	cytochrome c biogenesis protein
ISX45_RS09425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_RS09430	COG1187	pseudouridine synthase activity
ISX45_RS09440	COG2801	Transposase and inactivated derivatives
ISX45_RS09445	COG0700	Nucleoside recognition
ISX45_RS09450	COG2715	membrane protein required for spore maturation
ISX45_RS09455	COG1686	Belongs to the peptidase S11 family
ISX45_RS09460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISX45_RS09480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISX45_RS09485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISX45_RS09490	COG1547	Domain of unknown function (DUF309)
ISX45_RS09500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISX45_RS09505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISX45_RS09505	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISX45_RS09510	COG0307	riboflavin synthase, alpha
ISX45_RS09515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISX45_RS09515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISX45_RS09520	COG2188	Transcriptional regulator
ISX45_RS09530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISX45_RS09535	COG4086	secreted protein
ISX45_RS09545	COG0697	spore germination
ISX45_RS09560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX45_RS09585	COG2172	sigma factor antagonist activity
ISX45_RS09595	COG1686	Belongs to the peptidase S11 family
ISX45_RS09615	COG4974	Belongs to the 'phage' integrase family
ISX45_RS09625	COG0735	belongs to the Fur family
ISX45_RS09630	COG1300	Membrane
ISX45_RS09635	COG1379	DNA repair
ISX45_RS09640	COG0494	nUDIX hydrolase
ISX45_RS09645	COG0667	Aldo Keto reductase
ISX45_RS09655	COG0295	cytidine deaminase activity
ISX45_RS09660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISX45_RS09670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISX45_RS09675	COG2390	Transcriptional regulator
ISX45_RS09690	COG4918	Iron-sulphur cluster biosynthesis
ISX45_RS09705	COG0300	oxidoreductase activity
ISX45_RS09710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX45_RS09715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISX45_RS09725	COG1902	pentaerythritol trinitrate reductase activity
ISX45_RS09730	COG1234	tRNA 3'-trailer cleavage
ISX45_RS09735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISX45_RS09740	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISX45_RS09745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ISX45_RS09765	COG0726	polysaccharide deacetylase
ISX45_RS09770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISX45_RS09795	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISX45_RS09805	COG0456	acetyltransferase
ISX45_RS09810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISX45_RS09815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISX45_RS09820	COG0346	lactoylglutathione lyase activity
ISX45_RS09830	COG1376	ErfK ybiS ycfS ynhG family protein
ISX45_RS09835	COG4129	membrane
ISX45_RS09840	COG1126	abc transporter atp-binding protein
ISX45_RS09845	COG0765	amino acid transport
ISX45_RS09850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX45_RS09865	COG1703	isobutyryl-CoA mutase activity
ISX45_RS09870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_RS09870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_RS09875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_RS09875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_RS09880	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISX45_RS09885	COG0022	dehydrogenase e1 component
ISX45_RS09890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISX45_RS09895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISX45_RS09910	COG0280	phosphate acetyltransferase
ISX45_RS09915	COG3829	transcription factor binding
ISX45_RS09915	COG3290	protein histidine kinase activity
ISX45_RS09925	COG0584	glycerophosphoryl diester phosphodiesterase
ISX45_RS09930	COG3093	addiction module antidote protein HigA
ISX45_RS09950	COG0438	transferase activity, transferring glycosyl groups
ISX45_RS09970	COG1086	Polysaccharide biosynthesis protein
ISX45_RS09995	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ISX45_RS10010	COG0750	zinc metalloprotease
ISX45_RS10015	COG0497	DNA recombination
ISX45_RS10020	COG1438	arginine binding
ISX45_RS10025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ISX45_RS10030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISX45_RS10040	COG1722	exodeoxyribonuclease VII activity
ISX45_RS10045	COG1570	exodeoxyribonuclease VII activity
ISX45_RS10050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISX45_RS10055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISX45_RS10060	COG1302	Protein conserved in bacteria
ISX45_RS10065	COG0439	Biotin carboxylase
ISX45_RS10070	COG0511	ligase activity, forming carbon-carbon bonds
ISX45_RS10110	COG3854	ATPases associated with a variety of cellular activities
ISX45_RS10120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISX45_RS10125	COG0006	proline dipeptidase activity
ISX45_RS10130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISX45_RS10140	COG3872	metal-dependent enzyme
ISX45_RS10150	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISX45_RS10155	COG1321	iron dependent repressor
ISX45_RS10175	COG5002	protein histidine kinase activity
ISX45_RS10185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISX45_RS10210	COG0095	Lipoate-protein ligase
ISX45_RS10215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISX45_RS10225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISX45_RS10230	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ISX45_RS10235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ISX45_RS10285	COG1598	PFAM Uncharacterised protein family UPF0150
ISX45_RS10355	COG1459	type II secretion system
ISX45_RS10360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISX45_RS10380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX45_RS10395	COG0011	TIGRFAM Protein of
ISX45_RS10405	COG1368	sulfuric ester hydrolase activity
ISX45_RS10410	COG1940	carbohydrate kinase activity
ISX45_RS10415	COG4483	Protein conserved in bacteria
ISX45_RS10420	COG0697	spore germination
ISX45_RS10430	COG0705	Rhomboid family
ISX45_RS10430	COG0457	Tetratricopeptide repeat
ISX45_RS10435	COG1011	Hydrolase
ISX45_RS10455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISX45_RS10460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISX45_RS10465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISX45_RS10480	COG0704	Plays a role in the regulation of phosphate uptake
ISX45_RS10490	COG0768	penicillin binding
ISX45_RS10495	COG0477	Major facilitator Superfamily
ISX45_RS10510	COG0840	transmembrane signaling receptor activity
ISX45_RS10515	COG5521	maltodextrose utilization protein MalA
ISX45_RS10520	COG0581	inorganic phosphate transmembrane transporter activity
ISX45_RS10525	COG0573	inorganic phosphate transmembrane transporter activity
ISX45_RS10530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISX45_RS10535	COG1388	LysM domain
ISX45_RS10540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ISX45_RS10545	COG4709	membrane
ISX45_RS10550	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ISX45_RS10555	COG0735	belongs to the Fur family
ISX45_RS10560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISX45_RS10565	COG1121	(ABC) transporter
ISX45_RS10580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ISX45_RS10595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISX45_RS10600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISX45_RS10605	COG2384	SAM-dependent methyltransferase
ISX45_RS10610	COG2010	Cytochrome c
ISX45_RS10620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISX45_RS10630	COG1671	Belongs to the UPF0178 family
ISX45_RS10635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISX45_RS10640	COG0517	IMP dehydrogenase activity
ISX45_RS10645	COG1381	Involved in DNA repair and RecF pathway recombination
ISX45_RS10655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISX45_RS10660	COG0295	cytidine deaminase activity
ISX45_RS10665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISX45_RS10670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ISX45_RS10675	COG1480	7TM receptor with intracellular HD hydrolase
ISX45_RS10680	COG1702	phosphate starvation-inducible protein PhoH
ISX45_RS10695	COG1610	YqeY-like protein
ISX45_RS10700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISX45_RS10705	COG1283	sodium-dependent phosphate transmembrane transporter activity
ISX45_RS10710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISX45_RS10715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISX45_RS10720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISX45_RS10725	COG2264	protein methyltransferase activity
ISX45_RS10730	COG0484	heat shock protein binding
ISX45_RS10735	COG0443	Heat shock 70 kDa protein
ISX45_RS10740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISX45_RS10745	COG1420	regulation of RNA biosynthetic process
ISX45_RS10750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISX45_RS10755	COG0481	GTPase activity
ISX45_RS10770	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX45_RS10775	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ISX45_RS10780	COG0268	Binds directly to 16S ribosomal RNA
ISX45_RS10785	COG1466	dna polymerase III delta subunit
ISX45_RS10795	COG0658	competence protein
ISX45_RS10795	COG2333	competence protein COMEC
ISX45_RS10800	COG2131	deaminase
ISX45_RS10805	COG1596	polysaccharide export
ISX45_RS10805	COG1555	photosystem II stabilization
ISX45_RS10810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISX45_RS10815	COG2226	methyltransferase
ISX45_RS10820	COG0799	negative regulation of ribosome biogenesis
ISX45_RS10825	COG1713	HD superfamily hydrolase involved in NAD metabolism
ISX45_RS10830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISX45_RS10835	COG1534	Rna-binding protein
ISX45_RS10840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISX45_RS10845	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ISX45_RS10850	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ISX45_RS10860	COG0688	phosphatidylethanolamine metabolic process
ISX45_RS10865	COG1183	phosphatidylcholine synthase activity
ISX45_RS10870	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISX45_RS10875	COG1360	Flagellar Motor Protein
ISX45_RS10880	COG0628	permease
ISX45_RS10895	COG0586	Pfam SNARE associated Golgi protein
ISX45_RS10910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISX45_RS10915	COG1279	arginine transmembrane transporter activity
ISX45_RS10920	COG0384	phenazine biosynthesis protein PhzF
ISX45_RS10925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISX45_RS10945	COG0626	cystathionine gamma-synthase activity
ISX45_RS10950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISX45_RS10955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISX45_RS10960	COG2226	methyltransferase
ISX45_RS10975	COG0768	penicillin binding
ISX45_RS10980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISX45_RS10985	COG0572	uridine kinase
ISX45_RS10990	COG0826	peptidase U32
ISX45_RS10995	COG0826	peptidase U32
ISX45_RS11000	COG4122	O-methyltransferase activity
ISX45_RS11005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISX45_RS11010	COG3906	Belongs to the UPF0473 family
ISX45_RS11015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISX45_RS11020	COG4472	Bacterial protein of unknown function (DUF965)
ISX45_RS11025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ISX45_RS11030	COG0628	permease
ISX45_RS11045	COG3881	PFAM PRC-barrel domain
ISX45_RS11050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISX45_RS11060	COG0482	sulfurtransferase activity
ISX45_RS11065	COG1104	cysteine desulfurase activity
ISX45_RS11070	COG1959	2 iron, 2 sulfur cluster binding
ISX45_RS11075	COG2364	Membrane
ISX45_RS11080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISX45_RS11085	COG1309	transcriptional regulator
ISX45_RS11090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISX45_RS11100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISX45_RS11110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ISX45_RS11115	COG0124	histidyl-tRNA synthetase
ISX45_RS11125	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX45_RS11125	COG3103	Sh3 type 3 domain protein
ISX45_RS11125	COG4991	sh3 domain protein
ISX45_RS11130	COG1490	D-aminoacyl-tRNA deacylase activity
ISX45_RS11135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISX45_RS11140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISX45_RS11145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISX45_RS11145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ISX45_RS11150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISX45_RS11155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX45_RS11155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISX45_RS11165	COG2244	polysaccharide biosynthetic process
ISX45_RS11175	COG1862	Preprotein translocase
ISX45_RS11180	COG0343	queuine tRNA-ribosyltransferase activity
ISX45_RS11185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISX45_RS11195	COG2255	four-way junction helicase activity
ISX45_RS11200	COG0632	four-way junction helicase activity
ISX45_RS11210	COG0217	transcriptional regulatory protein
ISX45_RS11220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISX45_RS11230	COG1388	LysM domain
ISX45_RS11235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ISX45_RS11240	COG0157	Belongs to the NadC ModD family
ISX45_RS11245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISX45_RS11250	COG1104	cysteine desulfurase activity
ISX45_RS11255	COG1827	regulation of RNA biosynthetic process
ISX45_RS11260	COG0494	nUDIX hydrolase
ISX45_RS11265	COG0077	Prephenate dehydratase
ISX45_RS11270	COG4492	Belongs to the UPF0735 family
ISX45_RS11275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISX45_RS11280	COG3290	protein histidine kinase activity
ISX45_RS11285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISX45_RS11290	COG2868	ribosomal protein
ISX45_RS11295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISX45_RS11300	COG1994	Peptidase M50
ISX45_RS11305	COG0739	heme binding
ISX45_RS11310	COG2894	cell division
ISX45_RS11315	COG0850	regulation of cytokinetic process
ISX45_RS11320	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISX45_RS11325	COG1792	Involved in formation and maintenance of cell shape
ISX45_RS11330	COG1077	Cell shape determining protein MreB Mrl
ISX45_RS11335	COG2003	Belongs to the UPF0758 family
ISX45_RS11340	COG0424	maF-like protein
ISX45_RS11370	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISX45_RS11380	COG1459	type II secretion system
ISX45_RS11390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISX45_RS11425	COG5492	domain, Protein
ISX45_RS11430	COG0285	dihydrofolate synthase activity
ISX45_RS11435	COG0525	valine-tRNA ligase activity
ISX45_RS11450	COG1388	LysM domain
ISX45_RS11450	COG1388	LysM domain
ISX45_RS11455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISX45_RS11460	COG0113	porphobilinogen synthase activity
ISX45_RS11465	COG1587	Uroporphyrinogen-III synthase
ISX45_RS11470	COG0181	hydroxymethylbilane synthase activity
ISX45_RS11475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISX45_RS11490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ISX45_RS11495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISX45_RS11500	COG1067	ATP-dependent peptidase activity
ISX45_RS11500	COG0470	DNA polymerase III
ISX45_RS11505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISX45_RS11510	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISX45_RS11520	COG0066	3-isopropylmalate dehydratase activity
ISX45_RS11525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISX45_RS11530	COG0473	3-isopropylmalate dehydrogenase activity
ISX45_RS11535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISX45_RS11540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISX45_RS11545	COG0440	acetolactate synthase activity
ISX45_RS11550	COG0028	Belongs to the TPP enzyme family
ISX45_RS11555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISX45_RS11565	COG0622	Phosphoesterase
ISX45_RS11570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISX45_RS11575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISX45_RS11580	COG5401	PFAM Sporulation and spore germination
ISX45_RS11585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISX45_RS11595	COG2197	response regulator
ISX45_RS11600	COG0824	Thioesterase
ISX45_RS11605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISX45_RS11610	COG1053	succinate dehydrogenase
ISX45_RS11615	COG2009	succinate dehydrogenase
ISX45_RS11620	COG1719	4-vinyl reductase, 4VR
ISX45_RS11630	COG0322	excinuclease ABC activity
ISX45_RS11650	COG0463	Glycosyl transferase, family 2
ISX45_RS11665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISX45_RS11680	COG0431	NADPH-dependent FMN reductase
ISX45_RS11685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX45_RS11690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISX45_RS11695	COG1116	anion transmembrane transporter activity
ISX45_RS11700	COG3118	belongs to the thioredoxin family
ISX45_RS11705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ISX45_RS11710	COG2086	electron transfer activity
ISX45_RS11715	COG1024	Enoyl-CoA hydratase
ISX45_RS11720	COG1309	transcriptional regulator
ISX45_RS11725	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_RS11730	COG3766	membrane
ISX45_RS11735	COG1193	negative regulation of DNA recombination
ISX45_RS11740	COG1796	DNA polymerase
ISX45_RS11740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ISX45_RS11745	COG1286	toxin biosynthetic process
ISX45_RS11750	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ISX45_RS11755	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ISX45_RS11765	COG1033	growth of symbiont in host cell
ISX45_RS11765	COG2409	Drug exporters of the RND superfamily
ISX45_RS11770	COG1846	Transcriptional regulator
ISX45_RS11785	COG3335	DDE superfamily endonuclease
ISX45_RS11790	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ISX45_RS11795	COG1131	(ABC) transporter
ISX45_RS11800	COG1131	(ABC) transporter
ISX45_RS11805	COG1725	Transcriptional regulator
ISX45_RS11820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISX45_RS11820	COG0072	phenylalanine-tRNA ligase activity
ISX45_RS11825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISX45_RS11835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISX45_RS11850	COG4106	trans-aconitate 2-methyltransferase activity
ISX45_RS11855	COG1363	Peptidase, m42
ISX45_RS11870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISX45_RS11875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ISX45_RS11885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ISX45_RS11895	COG1484	DNA-dependent DNA replication
ISX45_RS11900	COG3611	Membrane attachment protein
ISX45_RS11905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISX45_RS11915	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISX45_RS11920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISX45_RS11930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISX45_RS11940	COG5002	protein histidine kinase activity
ISX45_RS11945	COG0745	RESPONSE REGULATOR receiver
ISX45_RS11955	COG0039	L-malate dehydrogenase activity
ISX45_RS11960	COG0538	isocitrate dehydrogenase activity
ISX45_RS11965	COG0372	Belongs to the citrate synthase family
ISX45_RS11970	COG2707	UPF0756 membrane protein
ISX45_RS11975	COG0628	permease
ISX45_RS11980	COG3030	protein affecting phage T7 exclusion by the F plasmid
ISX45_RS11990	COG0205	6-phosphofructokinase activity
ISX45_RS11995	COG0825	malonyl-CoA metabolic process
ISX45_RS12000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISX45_RS12005	COG1725	Transcriptional regulator
ISX45_RS12010	COG0281	malic enzyme
ISX45_RS12015	COG0587	DNA-directed DNA polymerase activity
ISX45_RS12030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ISX45_RS12040	COG4109	DRTGG domain
ISX45_RS12045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISX45_RS12050	COG0006	proline dipeptidase activity
ISX45_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS12075	COG0589	response to stress
ISX45_RS12080	COG0165	Argininosuccinate lyase
ISX45_RS12085	COG0137	argininosuccinate synthase activity
ISX45_RS12095	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISX45_RS12100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ISX45_RS12105	COG0827	DNA restriction-modification system
ISX45_RS12110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISX45_RS12115	COG3874	Sporulation protein YtfJ
ISX45_RS12125	COG1714	RDD family
ISX45_RS12130	COG0616	signal peptide processing
ISX45_RS12135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISX45_RS12140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISX45_RS12150	COG0301	tRNA thio-modification
ISX45_RS12155	COG1104	cysteine desulfurase activity
ISX45_RS12160	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ISX45_RS12165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ISX45_RS12170	COG1956	GAF domain-containing protein
ISX45_RS12175	COG2203	Gaf domain
ISX45_RS12175	COG2199	diguanylate cyclase activity
ISX45_RS12180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISX45_RS12190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX45_RS12195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISX45_RS12200	COG0454	-acetyltransferase
ISX45_RS12205	COG0517	IMP dehydrogenase activity
ISX45_RS12210	COG0123	including yeast histone deacetylase and acetoin utilization protein
ISX45_RS12225	COG1605	Chorismate mutase
ISX45_RS12225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ISX45_RS12230	COG0849	cell division
ISX45_RS12235	COG3118	belongs to the thioredoxin family
ISX45_RS12240	COG4980	gas vesicle protein
ISX45_RS12245	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ISX45_RS12250	COG2309	aminopeptidase activity
ISX45_RS12260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISX45_RS12270	COG1674	ftsk spoiiie
ISX45_RS12270	COG1674	ftsk spoiiie
ISX45_RS12275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISX45_RS12280	COG4848	Belongs to the UPF0354 family
ISX45_RS12285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_RS12290	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ISX45_RS12295	COG1363	Peptidase, m42
ISX45_RS12305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISX45_RS12310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ISX45_RS12320	COG0510	thiamine kinase activity
ISX45_RS12325	COG1523	belongs to the glycosyl hydrolase 13 family
ISX45_RS12335	COG1346	cytolysis
ISX45_RS12340	COG1380	Effector of murein hydrolase LrgA
ISX45_RS12355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISX45_RS12360	COG1349	DNA-binding transcription factor activity
ISX45_RS12365	COG1187	pseudouridine synthase activity
ISX45_RS12375	COG2244	polysaccharide biosynthetic process
ISX45_RS12380	COG2081	HI0933 family
ISX45_RS12415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISX45_RS12420	COG0495	leucyl-tRNA aminoacylation
ISX45_RS12425	COG0640	Transcriptional regulator
ISX45_RS12430	COG2814	Major facilitator Superfamily
ISX45_RS12445	COG1242	4 iron, 4 sulfur cluster binding
ISX45_RS12450	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ISX45_RS12460	COG2267	carboxylic ester hydrolase activity
ISX45_RS12465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISX45_RS12470	COG4990	cell redox homeostasis
ISX45_RS12475	COG0367	asparagine synthase
ISX45_RS12480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISX45_RS12485	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ISX45_RS12495	COG1506	peptidase
ISX45_RS12500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISX45_RS12505	COG1116	anion transmembrane transporter activity
ISX45_RS12510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX45_RS12515	COG0494	nUDIX hydrolase
ISX45_RS12525	COG4824	toxin secretion phage lysis holin
ISX45_RS12530	COG0783	Belongs to the Dps family
ISX45_RS12545	COG0701	Predicted permease
ISX45_RS12550	COG1854	S-ribosylhomocysteine lyase activity
ISX45_RS12555	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISX45_RS12560	COG0288	reversible hydration of carbon dioxide
ISX45_RS12565	COG0523	cobalamin synthesis protein
ISX45_RS12590	COG0254	rRNA binding
ISX45_RS12595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISX45_RS12605	COG1271	oxidase subunit
ISX45_RS12610	COG1294	oxidase, subunit
ISX45_RS12645	COG4948	Mandelate Racemase Muconate Lactonizing
ISX45_RS12650	COG0318	PFAM AMP-dependent synthetase and ligase
ISX45_RS12655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISX45_RS12660	COG0596	Alpha beta hydrolase
ISX45_RS12665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ISX45_RS12670	COG1169	isochorismate synthase
ISX45_RS12675	COG1575	Belongs to the MenA family. Type 1 subfamily
ISX45_RS12680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISX45_RS12690	COG0058	SHG alpha-glucan phosphorylase activity
ISX45_RS12695	COG0297	glycogen (starch) synthase activity
ISX45_RS12705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ISX45_RS12855	COG1285	pathogenesis
ISX45_RS12875	COG1620	l-lactate permease
ISX45_RS12880	COG0039	L-malate dehydrogenase activity
ISX45_RS12895	COG2814	Major facilitator Superfamily
ISX45_RS12905	COG0840	transmembrane signaling receptor activity
ISX45_RS12910	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISX45_RS12915	COG1247	-acetyltransferase
ISX45_RS12930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISX45_RS12950	COG2340	Cysteine-rich secretory protein family
ISX45_RS12975	COG3335	DDE superfamily endonuclease
ISX45_RS12985	COG1280	lysine exporter protein (LysE YggA)
ISX45_RS13000	COG0402	S-adenosylhomocysteine deaminase activity
ISX45_RS13020	COG0531	amino acid
ISX45_RS13035	COG1979	alcohol dehydrogenase
ISX45_RS13040	COG2155	Conserved Protein
ISX45_RS13045	COG1098	S1 RNA binding domain
ISX45_RS13055	COG0436	Aminotransferase
ISX45_RS13060	COG1522	sequence-specific DNA binding
ISX45_RS13065	COG2267	carboxylic ester hydrolase activity
ISX45_RS13075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISX45_RS13080	COG2032	superoxide dismutase activity
ISX45_RS13090	COG5018	Exonuclease
ISX45_RS13095	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISX45_RS13120	COG1268	BioY protein
ISX45_RS13125	COG0306	phosphate transporter
ISX45_RS13130	COG1392	Phosphate transport regulator
ISX45_RS13135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISX45_RS13150	COG3584	3D domain protein
ISX45_RS13170	COG1252	NADH dehydrogenase
ISX45_RS13175	COG0492	ferredoxin-NADP+ reductase activity
ISX45_RS13180	COG5416	Lipopolysaccharide assembly protein A domain
ISX45_RS13185	COG2340	Cysteine-rich secretory protein family
ISX45_RS13205	COG0316	Belongs to the HesB IscA family
ISX45_RS13210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISX45_RS13220	COG4844	belongs to the
ISX45_RS13225	COG1252	NADH dehydrogenase
ISX45_RS13230	COG4837	Protein of unknown function (DUF1462)
ISX45_RS13235	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISX45_RS13240	COG0083	homoserine kinase activity
ISX45_RS13245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISX45_RS13250	COG0460	homoserine dehydrogenase
ISX45_RS13255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISX45_RS13260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISX45_RS13265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISX45_RS13270	COG0647	UMP catabolic process
ISX45_RS13280	COG2445	Protein of unknown function DUF86
ISX45_RS13295	COG4470	Protein conserved in bacteria
ISX45_RS13305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISX45_RS13310	COG0739	heme binding
ISX45_RS13330	COG3377	Domain of unknown function (DUF1805)
ISX45_RS13335	COG0737	Belongs to the 5'-nucleotidase family
ISX45_RS13340	COG0730	response to heat
ISX45_RS13345	COG1801	Protein of unknown function DUF72
ISX45_RS13350	COG0719	Fe-S assembly protein
ISX45_RS13355	COG0822	iron-sulfur transferase activity
ISX45_RS13360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISX45_RS13365	COG0719	Fe-S assembly protein
ISX45_RS13370	COG0396	ATPase activity
ISX45_RS13375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISX45_RS13385	COG1464	Belongs to the NlpA lipoprotein family
ISX45_RS13390	COG2011	ABC-type metal ion transport system permease component
ISX45_RS13395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISX45_RS13410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISX45_RS13415	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ISX45_RS13425	COG0509	glycine decarboxylation via glycine cleavage system
ISX45_RS13430	COG1393	Belongs to the ArsC family
ISX45_RS13435	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS13440	COG0183	Belongs to the thiolase family
ISX45_RS13445	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_RS13445	COG1024	Enoyl-CoA hydratase
ISX45_RS13455	COG0506	proline dehydrogenase activity
ISX45_RS13465	COG5577	PFAM Coat F domain
ISX45_RS13485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISX45_RS13490	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISX45_RS13520	COG0753	catalase activity
ISX45_RS13585	COG1511	domain protein
ISX45_RS13590	COG1674	ftsk spoiiie
ISX45_RS13595	COG4499	WXG100 protein secretion system (Wss), protein YukC
ISX45_RS13600	COG5417	Belongs to the EsaB family
ISX45_RS13605	COG4842	Belongs to the WXG100 family
ISX45_RS13660	COG1388	LysM domain
ISX45_RS13660	COG3584	3D domain protein
ISX45_RS13670	COG0702	epimerase
ISX45_RS13680	COG0482	sulfurtransferase activity
ISX45_RS13685	COG1959	2 iron, 2 sulfur cluster binding
ISX45_RS13695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISX45_RS13700	COG0557	exoribonuclease II activity
ISX45_RS13710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISX45_RS13720	COG0148	phosphopyruvate hydratase activity
ISX45_RS13725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ISX45_RS13730	COG0149	triose-phosphate isomerase activity
ISX45_RS13735	COG0126	phosphoglycerate kinase activity
ISX45_RS13755	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISX45_RS13765	COG0740	serine-type endopeptidase activity
ISX45_RS13770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_RS13775	COG1481	regulation of sporulation
ISX45_RS13780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISX45_RS13785	COG1660	Displays ATPase and GTPase activities
ISX45_RS13790	COG1051	belongs to the nudix hydrolase family
ISX45_RS13795	COG0492	ferredoxin-NADP+ reductase activity
ISX45_RS13800	COG0457	Tetratricopeptide repeat
ISX45_RS13805	COG0140	phosphoribosyl-ATP diphosphatase activity
ISX45_RS13805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISX45_RS13810	COG0107	imidazoleglycerol-phosphate synthase activity
ISX45_RS13815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ISX45_RS13820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISX45_RS13825	COG0131	Imidazoleglycerol-phosphate dehydratase
ISX45_RS13830	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISX45_RS13835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISX45_RS13840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ISX45_RS13860	COG0110	maltose O-acetyltransferase activity
ISX45_RS13865	COG0546	phosphoglycolate phosphatase activity
ISX45_RS13870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ISX45_RS13875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ISX45_RS13880	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ISX45_RS13885	COG1950	PFAM Membrane protein of
ISX45_RS13890	COG3595	metallopeptidase activity
ISX45_RS13900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISX45_RS13905	COG0556	nucleotide-excision repair
ISX45_RS13910	COG4897	Protein conserved in bacteria
ISX45_RS13915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX45_RS13920	COG0789	Transcriptional regulator
ISX45_RS13930	COG0463	Glycosyl transferase, family 2
ISX45_RS13940	COG0793	Belongs to the peptidase S41A family
ISX45_RS13940	COG3409	Peptidoglycan-binding domain 1 protein
ISX45_RS13950	COG1231	oxidoreductase activity
ISX45_RS13965	COG0411	ABC transporter
ISX45_RS13995	COG0640	Transcriptional regulator
ISX45_RS14005	COG3883	PFAM NLP P60 protein
ISX45_RS14005	COG0791	NLP P60 protein
ISX45_RS14010	COG2177	Part of the ABC transporter FtsEX involved in
ISX45_RS14015	COG2884	Cell division ATP-binding protein ftsE
ISX45_RS14030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISX45_RS14040	COG0653	protein targeting
ISX45_RS14055	COG1516	flagellar protein fliS
ISX45_RS14060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISX45_RS14070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX45_RS14080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISX45_RS14085	COG2089	acid synthase
ISX45_RS14095	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ISX45_RS14125	COG1216	Glycosyl transferase, family 2
ISX45_RS14150	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISX45_RS14165	COG1216	Glycosyl transferase, family 2
ISX45_RS14170	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS14175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISX45_RS14180	COG1086	Polysaccharide biosynthesis protein
ISX45_RS14200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX45_RS14205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISX45_RS14220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISX45_RS14225	COG4786	Flagellar basal body rod
ISX45_RS14225	COG1256	bacterial-type flagellum assembly
ISX45_RS14235	COG2747	anti-sigma28 factor FlgM
ISX45_RS14245	COG1728	Protein conserved in bacteria
ISX45_RS14260	COG1040	competence protein
ISX45_RS14265	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ISX45_RS14270	COG1307	EDD domain protein, DegV family
ISX45_RS14275	COG2197	response regulator
ISX45_RS14280	COG4585	Histidine kinase
ISX45_RS14285	COG1739	Uncharacterized protein family UPF0029
ISX45_RS14290	COG1316	TRANSCRIPTIONal
ISX45_RS14295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISX45_RS14300	COG0728	peptidoglycan biosynthetic process
ISX45_RS14315	COG0438	transferase activity, transferring glycosyl groups
ISX45_RS14325	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX45_RS14365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISX45_RS14370	COG4193	domain, Protein
ISX45_RS14375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX45_RS14380	COG0726	polysaccharide deacetylase
ISX45_RS14395	COG3764	Sortase (surface protein transpeptidase)
ISX45_RS14405	COG1063	alcohol dehydrogenase
ISX45_RS14410	COG4193	domain, Protein
ISX45_RS14475	COG0791	NLP P60 protein
ISX45_RS14495	COG0653	protein targeting
ISX45_RS14510	COG0728	peptidoglycan biosynthetic process
ISX45_RS14525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ISX45_RS14535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISX45_RS14540	COG1316	TRANSCRIPTIONal
ISX45_RS14550	COG1388	LysM domain
ISX45_RS14550	COG0791	NLP P60 protein
ISX45_RS14555	COG4715	Zinc finger, swim domain protein
ISX45_RS14560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ISX45_RS14570	COG1396	sequence-specific DNA binding
ISX45_RS14575	COG0629	single-stranded DNA binding
ISX45_RS14585	COG3764	Sortase (surface protein transpeptidase)
ISX45_RS14595	COG0527	aspartate kinase activity
ISX45_RS14610	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS14620	COG0477	Major facilitator Superfamily
ISX45_RS14625	COG1309	transcriptional regulator
ISX45_RS14635	COG1940	carbohydrate kinase activity
ISX45_RS14645	COG1175	transmembrane transport
ISX45_RS14650	COG1653	transport
ISX45_RS14655	COG2207	Transcriptional regulator
ISX45_RS14655	COG4753	response regulator
ISX45_RS14655	COG4753	response regulator
ISX45_RS14655	COG2207	Transcriptional regulator
ISX45_RS14660	COG2972	Histidine kinase
ISX45_RS14675	COG2723	6-phospho-beta-galactosidase activity
ISX45_RS14685	COG0673	inositol 2-dehydrogenase activity
ISX45_RS14695	COG1879	ABC-type sugar transport system periplasmic component
ISX45_RS14700	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISX45_RS14705	COG1129	ABC transporter
ISX45_RS14710	COG1869	D-ribose catabolic process
ISX45_RS14715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISX45_RS14720	COG1609	Transcriptional regulator
ISX45_RS14730	COG1175	transmembrane transport
ISX45_RS14735	COG0395	ABC-type sugar transport system, permease component
ISX45_RS14745	COG1609	Transcriptional regulator
ISX45_RS14760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISX45_RS14770	COG4786	Flagellar basal body rod
ISX45_RS14775	COG4786	Flagellar basal body rod
ISX45_RS14780	COG1077	Cell shape determining protein MreB Mrl
ISX45_RS14785	COG1609	Transcriptional regulator
ISX45_RS14795	COG0405	Gamma-glutamyltransferase
ISX45_RS14800	COG0739	heme binding
ISX45_RS14805	COG2385	sporulation resulting in formation of a cellular spore
ISX45_RS14810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ISX45_RS14820	COG4836	Membrane
ISX45_RS14825	COG1007	ATP synthesis coupled electron transport
ISX45_RS14830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISX45_RS14835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISX45_RS14840	COG0713	ATP synthesis coupled electron transport
ISX45_RS14845	COG0839	Belongs to the complex I subunit 6 family
ISX45_RS14855	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ISX45_RS14860	COG0649	NAD binding
ISX45_RS14865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISX45_RS14870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISX45_RS14875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISX45_RS14880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISX45_RS14885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ISX45_RS14890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ISX45_RS14895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISX45_RS14900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ISX45_RS14905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISX45_RS14915	COG0356	it plays a direct role in the translocation of protons across the membrane
ISX45_RS14930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISX45_RS14935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ISX45_RS14940	COG4475	Protein of unknown function (DUF436)
ISX45_RS14945	COG0698	ribose 5-phosphate isomerase
ISX45_RS14950	COG0840	transmembrane signaling receptor activity
ISX45_RS14960	COG1971	Probably functions as a manganese efflux pump
ISX45_RS14965	COG0009	L-threonylcarbamoyladenylate synthase
ISX45_RS14980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISX45_RS14990	COG2204	response regulator
ISX45_RS14995	COG5002	protein histidine kinase activity
ISX45_RS15010	COG1435	thymidine kinase activity
ISX45_RS15015	COG0254	rRNA binding
ISX45_RS15020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISX45_RS15025	COG1494	fructose-1,6-bisphosphatase
ISX45_RS15030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ISX45_RS15035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISX45_RS15045	COG2204	response regulator
ISX45_RS15055	COG4821	SIS domain
ISX45_RS15060	COG0504	CTP synthase activity
ISX45_RS15065	COG3343	RNA polymerase activity
ISX45_RS15070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_RS15070	COG1703	isobutyryl-CoA mutase activity
ISX45_RS15070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISX45_RS15080	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS15085	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS15090	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISX45_RS15095	COG0183	Belongs to the thiolase family
ISX45_RS15100	COG2181	nitrate reductase activity
ISX45_RS15100	COG0247	lactate metabolic process
ISX45_RS15105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISX45_RS15115	COG0018	arginyl-trna synthetase
ISX45_RS15120	COG4506	Protein conserved in bacteria
ISX45_RS15125	COG0010	Belongs to the arginase family
ISX45_RS15130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ISX45_RS15135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISX45_RS15145	COG1994	Peptidase M50
ISX45_RS15155	COG2252	PERMEase
ISX45_RS15160	COG3465	dGTPase activity
ISX45_RS15165	COG1078	dGTPase activity
ISX45_RS15170	COG4844	belongs to the
ISX45_RS15180	COG0095	Lipoate-protein ligase
ISX45_RS15185	COG0280	phosphate acetyltransferase
ISX45_RS15190	COG3253	May function as heme-dependent peroxidase
ISX45_RS15195	COG3773	Cell wall hydrolase
ISX45_RS15205	COG2363	Small membrane protein
ISX45_RS15220	COG0366	Alpha amylase catalytic
ISX45_RS15225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISX45_RS15230	COG0423	glycine-tRNA ligase activity
ISX45_RS15235	COG1216	Glycosyl transferase, family 2
ISX45_RS15240	COG0697	spore germination
ISX45_RS15245	COG0477	Major facilitator Superfamily
ISX45_RS15250	COG4187	Peptidase family M20/M25/M40
ISX45_RS15255	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ISX45_RS15255	COG2508	Transcriptional regulator
ISX45_RS15260	COG0686	Belongs to the AlaDH PNT family
ISX45_RS15265	COG0351	phosphomethylpyrimidine kinase
ISX45_RS15270	COG3153	acetyltransferase
ISX45_RS15270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISX45_RS15280	COG0765	amino acid transport
ISX45_RS15300	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISX45_RS15310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISX45_RS15320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISX45_RS15325	COG1113	amino acid transport
ISX45_RS15330	COG2197	response regulator
ISX45_RS15335	COG4585	Histidine kinase
ISX45_RS15345	COG1842	Phage shock protein A
ISX45_RS15360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISX45_RS15365	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS15365	COG1454	alcohol dehydrogenase
ISX45_RS15380	COG0723	plastoquinol--plastocyanin reductase activity
ISX45_RS15380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISX45_RS15385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_RS15385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_RS15385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_RS15390	COG3711	transcriptional antiterminator
ISX45_RS15390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_RS15395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_RS15395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISX45_RS15395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISX45_RS15400	COG1482	cell wall glycoprotein biosynthetic process
ISX45_RS15410	COG3973	AAA domain
ISX45_RS15420	COG1929	Belongs to the glycerate kinase type-1 family
ISX45_RS15425	COG2610	gluconate transmembrane transporter activity
ISX45_RS15430	COG3835	regulator
ISX45_RS15435	COG1785	Belongs to the alkaline phosphatase family
ISX45_RS15440	COG2140	Oxalate decarboxylase
ISX45_RS15445	COG3118	belongs to the thioredoxin family
ISX45_RS15465	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISX45_RS15475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX45_RS15480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISX45_RS15485	COG4853	Protein conserved in bacteria
ISX45_RS15490	COG4863	YycH protein
ISX45_RS15495	COG5002	protein histidine kinase activity
ISX45_RS15500	COG0745	RESPONSE REGULATOR receiver
ISX45_RS15505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISX45_RS15510	COG0305	Participates in initiation and elongation during chromosome replication
ISX45_RS15515	COG0359	binds to the 23S rRNA
ISX45_RS15520	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ISX45_RS15525	COG4241	membrane
ISX45_RS15530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISX45_RS15535	COG0629	single-stranded DNA binding
ISX45_RS15540	COG0360	Binds together with S18 to 16S ribosomal RNA
ISX45_RS15545	COG0012	GTP binding
ISX45_RS15550	COG0243	molybdopterin cofactor binding
ISX45_RS15555	COG4481	Protein conserved in bacteria
ISX45_RS15560	COG0668	transmembrane transport
ISX45_RS15575	COG1475	DNA binding
ISX45_RS15580	COG1192	Involved in chromosome partitioning
ISX45_RS15585	COG1475	DNA binding
ISX45_RS15590	COG0357	Ribosomal RNA small subunit methyltransferase G
ISX45_RS15595	COG0445	tRNA wobble uridine modification
ISX45_RS15600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ISX45_RS15605	COG1847	R3H domain protein
ISX45_RS15610	COG0706	membrane insertase activity
ISX45_RS15615	COG0594	ribonuclease P activity
ISX45_RS15620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ISX45_RS15625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ISX45_RS15630	COG0592	DNA-directed DNA polymerase activity
ISX45_RS15635	COG2501	S4 domain
ISX45_RS15640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISX45_RS15645	COG0187	DNA topoisomerase II activity
ISX45_RS15650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISX45_RS15690	COG0517	IMP dehydrogenase activity
ISX45_RS15690	COG0516	GMP reductase activity
ISX45_RS15700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ISX45_RS15705	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ISX45_RS15710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ISX45_RS15720	COG1428	Deoxynucleoside kinase
ISX45_RS15725	COG1428	Deoxynucleoside kinase
ISX45_RS15730	COG3858	chitin binding
ISX45_RS15730	COG1388	LysM domain
ISX45_RS15735	COG0590	tRNA wobble adenosine to inosine editing
ISX45_RS15745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISX45_RS15750	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ISX45_RS15755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ISX45_RS15800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISX45_RS15805	COG0765	amino acid transport
ISX45_RS15810	COG0765	amino acid transport
ISX45_RS15820	COG1982	Orn Lys Arg decarboxylase major
ISX45_RS15825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISX45_RS15830	COG0470	DNA polymerase III
ISX45_RS15835	COG1774	PSP1 C-terminal conserved region
ISX45_RS15840	COG4467	Involved in initiation control of chromosome replication
ISX45_RS15845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ISX45_RS15850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISX45_RS15855	COG2002	toxin-antitoxin pair type II binding
ISX45_RS15865	COG0084	hydrolase, TatD family'
ISX45_RS15870	COG3584	3D domain protein
ISX45_RS15870	COG3583	domain protein
ISX45_RS15880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISX45_RS15890	COG4466	Protein conserved in bacteria
ISX45_RS15900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISX45_RS15905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISX45_RS15910	COG0251	oxidation-reduction process
ISX45_RS15915	COG2088	sporulation resulting in formation of a cellular spore
ISX45_RS15920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISX45_RS15930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ISX45_RS15935	COG0193	aminoacyl-tRNA hydrolase activity
ISX45_RS15945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISX45_RS15950	COG2002	toxin-antitoxin pair type II binding
ISX45_RS15955	COG2244	polysaccharide biosynthetic process
ISX45_RS15960	COG3956	TIGRFAM MazG family protein
ISX45_RS15965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISX45_RS15985	COG1098	S1 RNA binding domain
ISX45_RS16000	COG2208	phosphoserine phosphatase activity
ISX45_RS16005	COG2304	oxidoreductase activity
ISX45_RS16010	COG0515	serine threonine protein kinase
ISX45_RS16015	COG0037	tRNA processing
ISX45_RS16020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISX45_RS16025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISX45_RS16030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISX45_RS16035	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISX45_RS16040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISX45_RS16045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISX45_RS16050	COG0512	Glutamine amidotransferase of anthranilate synthase
ISX45_RS16055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISX45_RS16060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISX45_RS16065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISX45_RS16070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISX45_RS16075	COG1396	sequence-specific DNA binding
ISX45_RS16080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISX45_RS16170	COG3880	PFAM UvrB UvrC protein
ISX45_RS16175	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ISX45_RS16180	COG0542	response to heat
ISX45_RS16185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISX45_RS16190	COG4956	integral membrane protein (PIN domain superfamily)
ISX45_RS16195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISX45_RS16200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISX45_RS16205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISX45_RS16210	COG1045	serine acetyltransferase
ISX45_RS16215	COG0215	cysteine-tRNA ligase activity
ISX45_RS16225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISX45_RS16230	COG3688	RNA-binding protein containing a PIN domain
ISX45_RS16240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISX45_RS16245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISX45_RS16250	COG0250	Participates in transcription elongation, termination and antitermination
ISX45_RS16260	COG0081	regulation of translation
ISX45_RS16265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ISX45_RS16270	COG0222	ribosome binding
ISX45_RS16275	COG2813	Specifically methylates the guanine in position
ISX45_RS16280	COG0085	RNA polymerase activity
ISX45_RS16285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISX45_RS16290	COG1358	cellular component organization or biogenesis
ISX45_RS16295	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISX45_RS16300	COG0049	tRNA binding
ISX45_RS16305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISX45_RS16310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISX45_RS16315	COG0051	transcription antitermination factor activity, RNA binding
ISX45_RS16320	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ISX45_RS16325	COG0088	Forms part of the polypeptide exit tunnel
ISX45_RS16330	COG0089	rRNA binding
ISX45_RS16335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISX45_RS16340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISX45_RS16345	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ISX45_RS16350	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISX45_RS16355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISX45_RS16360	COG0255	Belongs to the universal ribosomal protein uL29 family
ISX45_RS16365	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISX45_RS16380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISX45_RS16385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISX45_RS16390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ISX45_RS16400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ISX45_RS16405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ISX45_RS16415	COG0200	Binds to the 23S rRNA
ISX45_RS16420	COG0201	protein transport
ISX45_RS16425	COG0563	adenylate kinase activity
ISX45_RS16430	COG0024	Methionine aminopeptidase
ISX45_RS16435	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ISX45_RS16440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISX45_RS16445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISX45_RS16450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ISX45_RS16455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ISX45_RS16460	COG0202	RNA polymerase activity
ISX45_RS16465	COG0203	ribosomal protein L17
ISX45_RS16470	COG1122	ATPase activity
ISX45_RS16475	COG1122	ATPase activity
ISX45_RS16480	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ISX45_RS16485	COG0101	tRNA pseudouridine synthase activity
ISX45_RS16490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ISX45_RS16495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ISX45_RS16505	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISX45_RS16510	COG0489	protein tyrosine kinase activity
ISX45_RS16520	COG2194	sulfuric ester hydrolase activity
ISX45_RS16525	COG0726	polysaccharide deacetylase
ISX45_RS16600	COG1595	DNA-templated transcription, initiation
ISX45_RS16605	COG5662	AntiSigma factor
ISX45_RS16610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ISX45_RS16615	COG4856	YbbR-like protein
ISX45_RS16620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISX45_RS16625	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISX45_RS16640	COG1136	(ABC) transporter
ISX45_RS16650	COG0745	RESPONSE REGULATOR receiver
ISX45_RS16665	COG2205	protein histidine kinase activity
ISX45_RS16675	COG3335	DDE superfamily endonuclease
ISX45_RS16680	COG1819	glycosyl
ISX45_RS16695	COG1247	-acetyltransferase
ISX45_RS16740	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS16755	COG0778	Nitroreductase
ISX45_RS16760	COG2259	Doxx family
ISX45_RS16770	COG0789	Transcriptional regulator
ISX45_RS16775	COG2207	Transcriptional regulator
ISX45_RS16790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISX45_RS16795	COG0745	RESPONSE REGULATOR receiver
ISX45_RS16800	COG3850	Histidine kinase
ISX45_RS16800	COG2205	protein histidine kinase activity
ISX45_RS16800	COG3437	response regulator, receiver
ISX45_RS16800	COG4999	Histidine kinase
ISX45_RS16820	COG0500	methyltransferase
ISX45_RS16825	COG0789	Transcriptional regulator
ISX45_RS16850	COG2318	DinB family
ISX45_RS16855	COG1917	Cupin 2, conserved barrel domain protein
ISX45_RS16855	COG1396	sequence-specific DNA binding
ISX45_RS16880	COG2197	response regulator
ISX45_RS16890	COG1131	(ABC) transporter
ISX45_RS16900	COG0842	Transport permease protein
ISX45_RS16910	COG1404	Belongs to the peptidase S8 family
ISX45_RS16920	COG1368	sulfuric ester hydrolase activity
ISX45_RS16930	COG1968	undecaprenyl-diphosphatase activity
ISX45_RS16940	COG0531	amino acid
ISX45_RS16945	COG1971	Probably functions as a manganese efflux pump
ISX45_RS16960	COG2197	response regulator
ISX45_RS16965	COG0431	NADPH-dependent FMN reductase
ISX45_RS16975	COG1960	acyl-CoA dehydrogenase activity
ISX45_RS16995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISX45_RS17015	COG0018	arginyl-trna synthetase
ISX45_RS17020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISX45_RS17030	COG0586	Pfam SNARE associated Golgi protein
ISX45_RS17035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISX45_RS17045	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISX45_RS17050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISX45_RS17060	COG0513	Belongs to the DEAD box helicase family
ISX45_RS17065	COG3402	PFAM membrane-flanked domain
ISX45_RS17070	COG3428	Bacterial PH domain
ISX45_RS17075	COG0705	Rhomboid family
ISX45_RS17080	COG0736	holo-[acyl-carrier-protein] synthase activity
ISX45_RS17085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ISX45_RS17090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISX45_RS17095	COG0864	Transcriptional regulator
ISX45_RS17100	COG2337	Toxic component of a toxin-antitoxin (TA) module
ISX45_RS17105	COG2183	response to ionizing radiation
ISX45_RS17115	COG3091	SprT-like family
ISX45_RS17200	COG0802	atpase or kinase
ISX45_RS17205	COG1214	PFAM Peptidase M22, glycoprotease
ISX45_RS17210	COG0456	acetyltransferase
ISX45_RS17215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ISX45_RS17220	COG0488	(ABC) transporter
ISX45_RS17225	COG0315	cyclic pyranopterin monophosphate synthase activity
ISX45_RS17230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ISX45_RS17235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISX45_RS17240	COG0805	protein transport
ISX45_RS17250	COG1266	CAAX protease self-immunity
ISX45_RS17255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ISX45_RS17260	COG0459	protein refolding
ISX45_RS17285	COG0459	protein refolding
ISX45_RS17295	COG0714	Associated with various cellular activities
ISX45_RS17300	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ISX45_RS17305	COG1305	Transglutaminase-like
ISX45_RS17310	COG0519	Catalyzes the synthesis of GMP from XMP
ISX45_RS17310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISX45_RS17315	COG2252	PERMEase
ISX45_RS17320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX45_RS17345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISX45_RS17350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISX45_RS17355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISX45_RS17360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ISX45_RS17365	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISX45_RS17370	COG0047	phosphoribosylformylglycinamidine synthase activity
ISX45_RS17375	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISX45_RS17380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISX45_RS17385	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ISX45_RS17390	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISX45_RS17395	COG0138	bifunctional purine biosynthesis protein purh
ISX45_RS17400	COG0151	Belongs to the GarS family
ISX45_RS17410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ISX45_RS17415	COG1470	cell adhesion involved in biofilm formation
ISX45_RS17420	COG4496	protein, YerC YecD
ISX45_RS17425	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ISX45_RS17435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISX45_RS17440	COG4851	CamS sex pheromone cAM373 precursor
ISX45_RS17445	COG1012	belongs to the aldehyde dehydrogenase family
ISX45_RS17460	COG3335	DDE superfamily endonuclease
ISX45_RS17485	COG1131	(ABC) transporter
ISX45_RS17505	COG1132	(ABC) transporter
ISX45_RS17520	COG1522	sequence-specific DNA binding
ISX45_RS17525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ISX45_RS17530	COG0154	amidase activity
ISX45_RS17535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ISX45_RS17540	COG1174	glycine betaine transport
ISX45_RS17545	COG0517	IMP dehydrogenase activity
ISX45_RS17545	COG1125	glycine betaine transport
ISX45_RS17585	COG1518	maintenance of DNA repeat elements
ISX45_RS17590	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISX45_RS17620	COG3842	ATPase activity
ISX45_RS17625	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISX45_RS17635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISX45_RS17640	COG2329	Antibiotic biosynthesis monooxygenase
ISX45_RS17645	COG1842	Phage shock protein A
ISX45_RS17655	COG5002	protein histidine kinase activity
ISX45_RS17665	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISX45_RS17670	COG2268	Band 7 protein
ISX45_RS17675	COG1597	lipid kinase activity
ISX45_RS17715	COG2966	Psort location CytoplasmicMembrane, score
ISX45_RS17720	COG3610	response to peptide
ISX45_RS17745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISX45_RS17760	COG0789	Transcriptional regulator
ISX45_RS17760	COG4978	Transcriptional regulator
ISX45_RS17780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISX45_RS17805	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ISX45_RS17810	COG5002	protein histidine kinase activity
ISX45_RS17825	COG0840	transmembrane signaling receptor activity
ISX45_RS17825	COG3290	protein histidine kinase activity
ISX45_RS17830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ISX45_RS17840	COG2814	Major facilitator Superfamily
ISX45_RS17845	COG0789	Transcriptional regulator
ISX45_RS17850	COG1511	domain protein
ISX45_RS17855	COG1511	domain protein
ISX45_RS17860	COG2080	2 iron, 2 sulfur cluster binding
ISX45_RS17870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISX45_RS17875	COG2068	MobA-Related Protein
ISX45_RS17880	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ISX45_RS17885	COG0604	alcohol dehydrogenase
ISX45_RS17910	COG2986	histidine ammonia-lyase
ISX45_RS17915	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISX45_RS17920	COG1228	amidohydrolase
ISX45_RS17925	COG0010	Belongs to the arginase family
ISX45_RS17940	COG0861	Integral membrane protein TerC family
ISX45_RS17950	COG1556	Lactate utilization protein
ISX45_RS17955	COG1139	Iron-sulfur cluster binding protein
ISX45_RS17960	COG0247	lactate metabolic process
ISX45_RS17965	COG2186	Transcriptional regulator
ISX45_RS17970	COG1620	l-lactate permease
ISX45_RS17980	COG1077	Cell shape determining protein MreB Mrl
ISX45_RS17990	COG0791	NLP P60 protein
ISX45_RS17990	COG1388	LysM domain
ISX45_RS17995	COG5001	Diguanylate cyclase
ISX45_RS17995	COG3300	MHYT domain
ISX45_RS18010	COG0745	RESPONSE REGULATOR receiver
ISX45_RS18015	COG2205	protein histidine kinase activity
ISX45_RS18015	COG2770	Histidine kinase
ISX45_RS18025	COG0384	phenazine biosynthesis protein PhzF
ISX45_RS18040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISX45_RS18045	COG0010	Belongs to the arginase family
ISX45_RS18050	COG1254	Belongs to the acylphosphatase family
ISX45_RS18075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISX45_RS18080	COG0529	Catalyzes the synthesis of activated sulfate
ISX45_RS18085	COG2046	Belongs to the sulfate adenylyltransferase family
ISX45_RS18090	COG0306	phosphate transporter
ISX45_RS18095	COG0175	sulfate reduction
ISX45_RS18110	COG4840	Belongs to the UPF0435 family
ISX45_RS18115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISX45_RS18125	COG1295	ribonuclease BN
ISX45_RS18135	COG0477	Major facilitator Superfamily
ISX45_RS18145	COG0387	Pfam Sodium calcium exchanger
ISX45_RS18155	COG0535	radical SAM domain protein
ISX45_RS18170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISX45_RS18175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISX45_RS18195	COG1309	transcriptional regulator
ISX45_RS18240	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS18270	COG0840	transmembrane signaling receptor activity
ISX45_RS18275	COG0835	chemotaxis
ISX45_RS18295	COG2197	response regulator
ISX45_RS18325	COG1090	epimerase
ISX45_RS18330	COG2137	regulation of response to DNA damage stimulus
ISX45_RS18360	COG1988	membrane-bound metal-dependent
ISX45_RS18370	COG3383	formate dehydrogenase (NAD+) activity
ISX45_RS18375	COG5609	conserved protein (DUF2294)
ISX45_RS18380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ISX45_RS18385	COG2116	formate transmembrane transporter activity
ISX45_RS18400	COG1028	Short-chain dehydrogenase reductase Sdr
ISX45_RS18415	COG3557	Belongs to the UPF0374 family
ISX45_RS18420	COG1132	(ABC) transporter
ISX45_RS18430	COG0444	Belongs to the ABC transporter superfamily
ISX45_RS18435	COG4608	Belongs to the ABC transporter superfamily
ISX45_RS18440	COG0747	negative chemotaxis
ISX45_RS18445	COG0601	transmembrane transport
ISX45_RS18450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISX45_RS18455	COG4129	membrane
ISX45_RS18460	COG0070	glutamate synthase
ISX45_RS18460	COG0069	glutamate synthase activity
ISX45_RS18460	COG0067	glutamate synthase
ISX45_RS18465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISX45_RS18470	COG4555	ABC transporter
ISX45_RS18485	COG0577	efflux transmembrane transporter activity
ISX45_RS18490	COG1136	(ABC) transporter
ISX45_RS18495	COG2205	protein histidine kinase activity
ISX45_RS18500	COG0745	RESPONSE REGULATOR receiver
ISX45_RS18510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISX45_RS18515	COG0735	belongs to the Fur family
ISX45_RS18625	COG4974	Belongs to the 'phage' integrase family
ISX45_RS18730	COG0204	Acyl-transferase
ISX45_RS18735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISX45_RS18740	COG0583	DNA-binding transcription factor activity
ISX45_RS18760	COG2318	DinB family
ISX45_RS18780	COG0384	phenazine biosynthesis protein PhzF
ISX45_RS18795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_RS18795	COG2207	Transcriptional regulator
ISX45_RS18800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISX45_RS18805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_RS18810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISX45_RS18815	COG0778	Nitroreductase
ISX45_RS18820	COG2819	hydrolase of the alpha beta superfamily
ISX45_RS18825	COG2819	hydrolase of the alpha beta superfamily
ISX45_RS18845	COG3382	B3 4 domain protein
ISX45_RS18860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISX45_RS18865	COG2766	serine protein kinase
ISX45_RS18875	COG3177	Filamentation induced by cAMP protein fic
ISX45_RS18915	COG0582	viral genome integration into host DNA
ISX45_RS18975	COG3331	DNA recombination
ISX45_RS19075	COG0740	serine-type endopeptidase activity
ISX45_RS19205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair