locus-tag	class	description
CA592_RS00035	COG0546	phosphoglycolate phosphatase activity
CA592_RS00050	COG0758	DNA mediated transformation
CA592_RS00050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CA592_RS00085	COG3328	transposase activity
CA592_RS00120	COG1518	maintenance of DNA repeat elements
CA592_RS00125	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CA592_RS00135	COG3335	DDE superfamily endonuclease
CA592_RS00155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CA592_RS00160	COG1360	Flagellar Motor Protein
CA592_RS00165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CA592_RS00170	COG1183	phosphatidylcholine synthase activity
CA592_RS00175	COG0688	phosphatidylethanolamine metabolic process
CA592_RS00185	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CA592_RS00190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CA592_RS00195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CA592_RS00200	COG1534	Rna-binding protein
CA592_RS00205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CA592_RS00210	COG1713	HD superfamily hydrolase involved in NAD metabolism
CA592_RS00215	COG0799	negative regulation of ribosome biogenesis
CA592_RS00220	COG2226	methyltransferase
CA592_RS00225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CA592_RS00230	COG1596	polysaccharide export
CA592_RS00230	COG1555	photosystem II stabilization
CA592_RS00235	COG2131	deaminase
CA592_RS00240	COG2333	competence protein COMEC
CA592_RS00240	COG0658	competence protein
CA592_RS00250	COG1466	dna polymerase III delta subunit
CA592_RS00260	COG0268	Binds directly to 16S ribosomal RNA
CA592_RS00265	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CA592_RS00270	COG0860	N-Acetylmuramoyl-L-alanine amidase
CA592_RS00280	COG0481	GTPase activity
CA592_RS00285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CA592_RS00290	COG1420	regulation of RNA biosynthetic process
CA592_RS00295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CA592_RS00300	COG0443	Heat shock 70 kDa protein
CA592_RS00305	COG0484	heat shock protein binding
CA592_RS00310	COG2264	protein methyltransferase activity
CA592_RS00315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CA592_RS00320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CA592_RS00325	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CA592_RS00330	COG1610	YqeY-like protein
CA592_RS00335	COG1030	water channel activity
CA592_RS00340	COG4864	UPF0365 protein
CA592_RS00360	COG1702	phosphate starvation-inducible protein PhoH
CA592_RS00365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CA592_RS00370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CA592_RS00375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CA592_RS00385	COG1381	Involved in DNA repair and RecF pathway recombination
CA592_RS00390	COG0517	IMP dehydrogenase activity
CA592_RS00395	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CA592_RS00405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CA592_RS00415	COG2010	Cytochrome c
CA592_RS00420	COG2384	SAM-dependent methyltransferase
CA592_RS00425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CA592_RS00430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CA592_RS00445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CA592_RS00455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CA592_RS00460	COG1121	(ABC) transporter
CA592_RS00465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CA592_RS00470	COG0735	belongs to the Fur family
CA592_RS00475	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CA592_RS00480	COG4709	membrane
CA592_RS00485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CA592_RS00490	COG1388	LysM domain
CA592_RS00505	COG5521	maltodextrose utilization protein MalA
CA592_RS00525	COG0477	Major facilitator Superfamily
CA592_RS00530	COG0768	penicillin binding
CA592_RS00535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CA592_RS00540	COG0573	inorganic phosphate transmembrane transporter activity
CA592_RS00545	COG0581	inorganic phosphate transmembrane transporter activity
CA592_RS00555	COG0704	Plays a role in the regulation of phosphate uptake
CA592_RS00575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CA592_RS00580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CA592_RS00585	COG0039	L-malate dehydrogenase activity
CA592_RS00595	COG0457	Tetratricopeptide repeat
CA592_RS00595	COG0705	Rhomboid family
CA592_RS00605	COG0697	spore germination
CA592_RS00610	COG4483	Protein conserved in bacteria
CA592_RS00615	COG1940	carbohydrate kinase activity
CA592_RS00620	COG1368	sulfuric ester hydrolase activity
CA592_RS00635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CA592_RS00655	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CA592_RS00660	COG1459	type II secretion system
CA592_RS00665	COG4537	Required for transformation and DNA binding
CA592_RS00670	COG4970	Tfp pilus assembly protein FimT
CA592_RS00705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CA592_RS00710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CA592_RS00715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CA592_RS00720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CA592_RS00750	COG5002	protein histidine kinase activity
CA592_RS00760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CA592_RS00765	COG0095	Lipoate-protein ligase
CA592_RS00770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CA592_RS00780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CA592_RS00785	COG1533	DNA photolyase activity
CA592_RS00790	COG1321	iron dependent repressor
CA592_RS00795	COG1752	Esterase of the alpha-beta hydrolase superfamily
CA592_RS00805	COG3872	metal-dependent enzyme
CA592_RS00815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CA592_RS00820	COG0006	proline dipeptidase activity
CA592_RS00825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CA592_RS00835	COG3854	ATPases associated with a variety of cellular activities
CA592_RS00875	COG0511	ligase activity, forming carbon-carbon bonds
CA592_RS00880	COG0439	Biotin carboxylase
CA592_RS00885	COG1302	Protein conserved in bacteria
CA592_RS00890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CA592_RS00895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CA592_RS00900	COG1570	exodeoxyribonuclease VII activity
CA592_RS00905	COG1722	exodeoxyribonuclease VII activity
CA592_RS00915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CA592_RS00920	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CA592_RS00930	COG0497	DNA recombination
CA592_RS00935	COG0750	zinc metalloprotease
CA592_RS00945	COG3093	addiction module antidote protein HigA
CA592_RS00950	COG0584	glycerophosphoryl diester phosphodiesterase
CA592_RS00960	COG3290	protein histidine kinase activity
CA592_RS00960	COG3829	transcription factor binding
CA592_RS00965	COG0280	phosphate acetyltransferase
CA592_RS00975	COG3426	butyrate kinase activity
CA592_RS00980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CA592_RS00985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CA592_RS00995	COG0508	dehydrogenase complex catalyzes the overall conversion of
CA592_RS01000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CA592_RS01000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CA592_RS01005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CA592_RS01005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CA592_RS01015	COG4129	membrane
CA592_RS01025	COG0346	lactoylglutathione lyase activity
CA592_RS01030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CA592_RS01035	COG2195	Cleaves the N-terminal amino acid of tripeptides
CA592_RS01045	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CA592_RS01050	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CA592_RS01055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CA592_RS01060	COG1234	tRNA 3'-trailer cleavage
CA592_RS01080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CA592_RS01085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CA592_RS01090	COG0300	oxidoreductase activity
CA592_RS01095	COG4918	Iron-sulphur cluster biosynthesis
CA592_RS01110	COG0535	radical SAM domain protein
CA592_RS01120	COG3328	transposase activity
CA592_RS01125	COG2223	nitrite transmembrane transporter activity
CA592_RS01135	COG4149	molybdate abc transporter
CA592_RS01140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CA592_RS01145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CA592_RS01155	COG0746	molybdenum cofactor guanylyltransferase activity
CA592_RS01160	COG0303	'Molybdopterin
CA592_RS01165	COG1763	Mo-molybdopterin cofactor biosynthetic process
CA592_RS01180	COG0315	cyclic pyranopterin monophosphate synthase activity
CA592_RS01185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CA592_RS01190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CA592_RS01200	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CA592_RS01205	COG1140	nitrate reductase beta subunit
CA592_RS01210	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CA592_RS01215	COG2181	nitrate reductase activity
CA592_RS01235	COG0667	Aldo Keto reductase
CA592_RS01240	COG0494	nUDIX hydrolase
CA592_RS01245	COG1300	Membrane
CA592_RS01250	COG0735	belongs to the Fur family
CA592_RS01265	COG4974	Belongs to the 'phage' integrase family
CA592_RS01285	COG1686	Belongs to the peptidase S11 family
CA592_RS01295	COG2172	sigma factor antagonist activity
CA592_RS01320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CA592_RS01335	COG0697	spore germination
CA592_RS01340	COG0019	diaminopimelate decarboxylase activity
CA592_RS01350	COG4086	secreted protein
CA592_RS01355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CA592_RS01360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CA592_RS01360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CA592_RS01365	COG0307	riboflavin synthase, alpha
CA592_RS01370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CA592_RS01370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CA592_RS01375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CA592_RS01385	COG1547	Domain of unknown function (DUF309)
CA592_RS01390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CA592_RS01395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CA592_RS01405	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CA592_RS01415	COG1181	Belongs to the D-alanine--D-alanine ligase family
CA592_RS01440	COG1686	Belongs to the peptidase S11 family
CA592_RS01445	COG2715	membrane protein required for spore maturation
CA592_RS01450	COG0700	Nucleoside recognition
CA592_RS01460	COG1187	pseudouridine synthase activity
CA592_RS01465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CA592_RS01470	COG1333	cytochrome c biogenesis protein
CA592_RS01475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CA592_RS01480	COG0745	RESPONSE REGULATOR receiver
CA592_RS01485	COG5002	protein histidine kinase activity
CA592_RS01490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CA592_RS01495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CA592_RS01500	COG1120	ATPase activity
CA592_RS01515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CA592_RS01520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CA592_RS01530	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CA592_RS01545	COG2096	Adenosyltransferase
CA592_RS01565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CA592_RS01570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CA592_RS01585	COG4955	Helix-turn-helix domain
CA592_RS01590	COG0514	ATP-dependent DNA helicase (RecQ)
CA592_RS01595	COG1266	CAAX protease self-immunity
CA592_RS01615	COG1408	metallophosphoesterase
CA592_RS01620	COG0789	Transcriptional regulator
CA592_RS01625	COG4862	establishment of competence for transformation
CA592_RS01630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CA592_RS01635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CA592_RS01640	COG0492	ferredoxin-NADP+ reductase activity
CA592_RS01645	COG2959	enzyme of heme biosynthesis
CA592_RS01650	COG3773	Cell wall hydrolase
CA592_RS01650	COG3409	Peptidoglycan-binding domain 1 protein
CA592_RS01660	COG2339	peptidase activity
CA592_RS01665	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CA592_RS01675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CA592_RS01685	COG0539	negative regulation of cytoplasmic translation
CA592_RS01690	COG1304	FMN binding
CA592_RS01720	COG1160	GTP binding
CA592_RS01725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CA592_RS01740	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CA592_RS01750	COG0302	gtp cyclohydrolase
CA592_RS01760	COG0142	geranyltranstransferase activity
CA592_RS01765	COG2226	methyltransferase
CA592_RS01775	COG0105	UTP biosynthetic process
CA592_RS01780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CA592_RS01785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CA592_RS01790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CA592_RS01795	COG4401	Chorismate mutase type I
CA592_RS01805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CA592_RS01810	COG0134	indole-3-glycerol-phosphate synthase activity
CA592_RS01815	COG0135	phosphoribosylanthranilate isomerase activity
CA592_RS01820	COG0133	tryptophan synthase activity
CA592_RS01825	COG0159	tryptophan synthase activity
CA592_RS01830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CA592_RS01835	COG0287	Prephenate dehydrogenase
CA592_RS01840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CA592_RS01845	COG0457	Tetratricopeptide repeat
CA592_RS01850	COG5582	Belongs to the UPF0302 family
CA592_RS01875	COG4347	Protein of unknown function (DUF1405)
CA592_RS01885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CA592_RS01890	COG1694	Mazg nucleotide pyrophosphohydrolase
CA592_RS01895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CA592_RS01900	COG1803	Methylglyoxal synthase
CA592_RS01905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CA592_RS01910	COG0438	transferase activity, transferring glycosyl groups
CA592_RS01915	COG0617	tRNA 3'-terminal CCA addition
CA592_RS01925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CA592_RS01930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CA592_RS01935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CA592_RS01940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CA592_RS01940	COG1199	ATP-dependent helicase activity
CA592_RS01965	COG0017	Asparaginyl-tRNA synthetase
CA592_RS01970	COG3935	DnaD domain protein
CA592_RS01975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CA592_RS01990	COG4499	WXG100 protein secretion system (Wss), protein YukC
CA592_RS01990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CA592_RS01995	COG3331	DNA recombination
CA592_RS02025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CA592_RS02030	COG2217	Heavy metal translocating P-type atpase
CA592_RS02075	COG2202	Pas domain
CA592_RS02075	COG2200	EAL domain
CA592_RS02075	COG2199	diguanylate cyclase activity
CA592_RS02080	COG1120	ATPase activity
CA592_RS02095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CA592_RS02100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CA592_RS02105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CA592_RS02110	COG0156	8-amino-7-oxononanoate synthase activity
CA592_RS02115	COG0596	Alpha beta hydrolase
CA592_RS02120	COG4106	trans-aconitate 2-methyltransferase activity
CA592_RS02125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CA592_RS02130	COG0475	glutathione-regulated potassium exporter activity
CA592_RS02130	COG0569	domain protein
CA592_RS02140	COG1061	Type III restriction enzyme res subunit
CA592_RS02200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CA592_RS02250	COG1074	ATP-dependent DNA helicase activity
CA592_RS02265	COG0210	DNA helicase
CA592_RS02305	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CA592_RS02310	COG1968	undecaprenyl-diphosphatase activity
CA592_RS02345	COG5002	protein histidine kinase activity
CA592_RS02350	COG0745	RESPONSE REGULATOR receiver
CA592_RS02400	COG1937	Protein conserved in bacteria
CA592_RS02405	COG2217	Heavy metal translocating P-type atpase
CA592_RS02425	COG1271	oxidase subunit
CA592_RS02430	COG1294	oxidase, subunit
CA592_RS02440	COG0367	asparagine synthase
CA592_RS02465	COG0583	DNA-binding transcription factor activity
CA592_RS02470	COG0067	glutamate synthase
CA592_RS02470	COG0069	glutamate synthase activity
CA592_RS02470	COG0070	glutamate synthase
CA592_RS02475	COG0493	'glutamate synthase
CA592_RS02480	COG0129	dihydroxy-acid dehydratase activity
CA592_RS02485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CA592_RS02490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CA592_RS02500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CA592_RS02505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CA592_RS02520	COG4152	abc transporter atp-binding protein
CA592_RS02525	COG1668	transmembrane transport
CA592_RS02545	COG3335	DDE superfamily endonuclease
CA592_RS02570	COG1272	protein, Hemolysin III
CA592_RS02590	COG3314	Sporulation integral membrane protein YlbJ
CA592_RS02600	COG0531	amino acid
CA592_RS02605	COG0803	Belongs to the bacterial solute-binding protein 9 family
CA592_RS02610	COG1121	(ABC) transporter
CA592_RS02615	COG1321	iron dependent repressor
CA592_RS02615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CA592_RS02620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CA592_RS02640	COG3853	Toxic anion resistance protein (TelA)
CA592_RS02665	COG0697	spore germination
CA592_RS02670	COG4948	Mandelate Racemase Muconate Lactonizing
CA592_RS02710	COG1132	(ABC) transporter
CA592_RS02715	COG1132	(ABC) transporter
CA592_RS02765	COG0860	N-Acetylmuramoyl-L-alanine amidase
CA592_RS02795	COG3069	C4-dicarboxylate transmembrane transporter activity
CA592_RS02800	COG0004	ammonium transporteR
CA592_RS02810	COG1199	ATP-dependent helicase activity
CA592_RS02810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CA592_RS02815	COG0640	Transcriptional regulator
CA592_RS02835	COG5001	Diguanylate cyclase
CA592_RS02835	COG3706	GGDEF domain
CA592_RS02835	COG4251	negative regulation of phosphorylation
CA592_RS02835	COG2203	Gaf domain
CA592_RS02855	COG1131	(ABC) transporter
CA592_RS02865	COG1525	nuclease
CA592_RS02870	COG1151	hydroxylamine reductase activity
CA592_RS02875	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CA592_RS02880	COG0352	thiamine-phosphate diphosphorylase activity
CA592_RS02885	COG1024	Enoyl-CoA hydratase
CA592_RS02890	COG0840	transmembrane signaling receptor activity
CA592_RS02910	COG2202	Pas domain
CA592_RS02910	COG3920	Histidine kinase
CA592_RS02925	COG0116	Belongs to the methyltransferase superfamily
CA592_RS02930	COG1199	ATP-dependent helicase activity
CA592_RS02935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CA592_RS02945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CA592_RS02950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CA592_RS02970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CA592_RS02985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CA592_RS03005	COG0824	Thioesterase
CA592_RS03010	COG4841	protein insertion into membrane
CA592_RS03030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CA592_RS03045	COG4326	sporulation control protein
CA592_RS03080	COG1876	peptidase activity
CA592_RS03090	COG2056	Na+-H+ antiporter family
CA592_RS03095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CA592_RS03100	COG2962	Rard protein
CA592_RS03115	COG0534	Mate efflux family protein
CA592_RS03120	COG1115	amino acid carrier protein
CA592_RS03125	COG3852	Histidine kinase
CA592_RS03135	COG3546	catalase activity
CA592_RS03140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CA592_RS03160	COG1725	Transcriptional regulator
CA592_RS03165	COG1131	(ABC) transporter
CA592_RS03175	COG0826	peptidase U32
CA592_RS03185	COG1278	Cold shock
CA592_RS03195	COG2755	lipolytic protein G-D-S-L family
CA592_RS03200	COG1131	(ABC) transporter
CA592_RS03205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CA592_RS03225	COG0328	RNA-DNA hybrid ribonuclease activity
CA592_RS03225	COG3341	Caulimovirus viroplasmin
CA592_RS03255	COG1028	Short-chain dehydrogenase reductase Sdr
CA592_RS03260	COG1119	ATPase activity
CA592_RS03345	COG4548	von Willebrand factor, type A
CA592_RS03350	COG0714	Associated with various cellular activities
CA592_RS03355	COG1937	Protein conserved in bacteria
CA592_RS03365	COG0788	formyltetrahydrofolate deformylase activity
CA592_RS03375	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CA592_RS03380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CA592_RS03390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CA592_RS03395	COG0187	DNA topoisomerase II activity
CA592_RS03400	COG1832	CoA-binding protein
CA592_RS03405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CA592_RS03410	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CA592_RS03410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CA592_RS03420	COG2755	lipolytic protein G-D-S-L family
CA592_RS03425	COG1999	signal sequence binding
CA592_RS03440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CA592_RS03445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CA592_RS03450	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CA592_RS03460	COG0409	Hydrogenase expression formation protein
CA592_RS03465	COG0298	carbon dioxide binding
CA592_RS03470	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CA592_RS03475	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CA592_RS03480	COG0375	protein maturation
CA592_RS03520	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CA592_RS03540	COG0805	protein transport
CA592_RS03545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CA592_RS03560	COG2521	methyltransferase
CA592_RS03560	COG2136	Putative SAM-dependent methyltransferase
CA592_RS03575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CA592_RS03580	COG2814	Major facilitator Superfamily
CA592_RS03590	COG2233	PERMEase
CA592_RS03600	COG1984	allophanate hydrolase subunit 2
CA592_RS03605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CA592_RS03615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CA592_RS03620	COG1988	membrane-bound metal-dependent
CA592_RS03640	COG1587	Uroporphyrinogen-III synthase
CA592_RS03645	COG5002	protein histidine kinase activity
CA592_RS03650	COG0716	FMN binding
CA592_RS03660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CA592_RS03660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CA592_RS03660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CA592_RS03665	COG1105	Belongs to the carbohydrate kinase PfkB family
CA592_RS03670	COG1349	DNA-binding transcription factor activity
CA592_RS03695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CA592_RS03700	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CA592_RS03705	COG0432	Pfam Uncharacterised protein family UPF0047
CA592_RS03735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CA592_RS03745	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CA592_RS03760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CA592_RS03785	COG4846	Membrane protein involved in cytochrome C biogenesis
CA592_RS03790	COG2201	protein-glutamate methylesterase activity
CA592_RS03795	COG0785	Cytochrome C biogenesis protein
CA592_RS03800	COG3763	UPF0154 protein
CA592_RS03810	COG4224	UPF0291 protein
CA592_RS03815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CA592_RS03820	COG1388	LysM domain
CA592_RS03825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CA592_RS03830	COG0174	glutamine synthetase
CA592_RS03835	COG0789	Transcriptional regulator
CA592_RS03840	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CA592_RS03845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CA592_RS03850	COG2860	membrane
CA592_RS03855	COG0183	Belongs to the thiolase family
CA592_RS03860	COG0464	growth
CA592_RS03865	COG1923	regulation of RNA biosynthetic process
CA592_RS03870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CA592_RS03875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CA592_RS03880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CA592_RS03895	COG4550	Control of competence regulator ComK, YlbF/YmcA
CA592_RS03900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CA592_RS03905	COG1013	pyruvate-flavodoxin oxidoreductase activity
CA592_RS03910	COG0674	pyruvate-flavodoxin oxidoreductase activity
CA592_RS03910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CA592_RS03920	COG2359	stage V sporulation protein S
CA592_RS03925	COG1692	metallophosphoesterase
CA592_RS03930	COG1418	mRNA catabolic process
CA592_RS03940	COG1058	Belongs to the CinA family
CA592_RS03940	COG1546	Belongs to the CinA family
CA592_RS03945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CA592_RS03950	COG1426	Protein conserved in bacteria
CA592_RS03965	COG0300	oxidoreductase activity
CA592_RS03970	COG0612	Peptidase, M16
CA592_RS03975	COG0612	Peptidase, M16
CA592_RS03985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CA592_RS03995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CA592_RS04000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CA592_RS04010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CA592_RS04025	COG0789	Transcriptional regulator
CA592_RS04045	COG1597	lipid kinase activity
CA592_RS04050	COG5609	conserved protein (DUF2294)
CA592_RS04065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CA592_RS04075	COG0371	Dehydrogenase
CA592_RS04090	COG0612	Peptidase, M16
CA592_RS04095	COG1131	(ABC) transporter
CA592_RS04140	COG4191	Histidine kinase
CA592_RS04145	COG0784	Response regulator, receiver
CA592_RS04150	COG5002	protein histidine kinase activity
CA592_RS04160	COG2340	Cysteine-rich secretory protein family
CA592_RS04170	COG1414	Transcriptional regulator
CA592_RS04175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CA592_RS04180	COG1131	(ABC) transporter
CA592_RS04200	COG3773	Cell wall hydrolase
CA592_RS04210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CA592_RS04220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CA592_RS04240	COG2151	metal-sulfur cluster biosynthetic enzyme
CA592_RS04250	COG1131	(ABC) transporter
CA592_RS04280	COG1846	Transcriptional regulator
CA592_RS04290	COG1741	Belongs to the pirin family
CA592_RS04295	COG2223	nitrite transmembrane transporter activity
CA592_RS04305	COG2223	nitrite transmembrane transporter activity
CA592_RS04315	COG4989	oxidoreductase activity
CA592_RS04320	COG4377	Putative membrane peptidase family (DUF2324)
CA592_RS04330	COG0640	Transcriptional regulator
CA592_RS04340	COG0393	Putative heavy-metal-binding
CA592_RS04345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CA592_RS04355	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CA592_RS04360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CA592_RS04375	COG0393	Putative heavy-metal-binding
CA592_RS04380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CA592_RS04385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CA592_RS04400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CA592_RS04405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CA592_RS04460	COG0579	oxidoreductase
CA592_RS04470	COG2843	Capsule synthesis protein
CA592_RS04475	COG2610	gluconate transmembrane transporter activity
CA592_RS04480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CA592_RS04495	COG1079	Belongs to the binding-protein-dependent transport system permease family
CA592_RS04500	COG4603	Belongs to the binding-protein-dependent transport system permease family
CA592_RS04505	COG3845	ABC transporter
CA592_RS04510	COG1744	ABC transporter substrate-binding protein PnrA-like
CA592_RS04515	COG2188	Transcriptional regulator
CA592_RS04520	COG4980	gas vesicle protein
CA592_RS04520	COG1674	ftsk spoiiie
CA592_RS04530	COG0740	serine-type endopeptidase activity
CA592_RS04535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CA592_RS04545	COG0527	aspartate kinase activity
CA592_RS04550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CA592_RS04555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CA592_RS04560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CA592_RS04565	COG1873	PFAM PRC-barrel domain
CA592_RS04570	COG0612	Peptidase, M16
CA592_RS04575	COG0726	polysaccharide deacetylase
CA592_RS04580	COG1185	polyribonucleotide nucleotidyltransferase activity
CA592_RS04585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CA592_RS04590	COG0196	riboflavin kinase activity
CA592_RS04595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CA592_RS04600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CA592_RS04605	COG1550	Protein conserved in bacteria
CA592_RS04610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CA592_RS04615	COG1358	cellular component organization or biogenesis
CA592_RS04620	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CA592_RS04625	COG0195	Participates in both transcription termination and antitermination
CA592_RS04630	COG0779	Required for maturation of 30S ribosomal subunits
CA592_RS04635	COG2176	DNA-directed DNA polymerase activity
CA592_RS04640	COG0442	prolyl-tRNA aminoacylation
CA592_RS04645	COG0750	zinc metalloprotease
CA592_RS04650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CA592_RS04655	COG4589	Belongs to the CDS family
CA592_RS04660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CA592_RS04665	COG0233	cytoplasmic translational termination
CA592_RS04670	COG0528	UMP kinase activity
CA592_RS04675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CA592_RS04680	COG0052	Belongs to the universal ribosomal protein uS2 family
CA592_RS04695	COG1191	sigma factor activity
CA592_RS04705	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CA592_RS04710	COG1776	CheC inhibitor of MCP methylation
CA592_RS04715	COG0835	chemotaxis
CA592_RS04720	COG0643	Histidine kinase
CA592_RS04720	COG2198	Histidine kinase
CA592_RS04725	COG2201	protein-glutamate methylesterase activity
CA592_RS04730	COG0455	bacterial-type flagellum organization
CA592_RS04740	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CA592_RS04750	COG1684	flagellar biosynthetic protein fliR
CA592_RS04755	COG1987	bacterial-type flagellum assembly
CA592_RS04760	COG1338	Plays a role in the flagellum-specific transport system
CA592_RS04765	COG3190	flagellar
CA592_RS04770	COG2201	protein-glutamate methylesterase activity
CA592_RS04775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CA592_RS04775	COG1776	CheC inhibitor of MCP methylation
CA592_RS04780	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CA592_RS04785	COG1580	Controls the rotational direction of flagella during chemotaxis
CA592_RS04790	COG1582	Flagellar protein (FlbD)
CA592_RS04795	COG4786	Flagellar basal body rod
CA592_RS04805	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CA592_RS04810	COG3144	bacterial-type flagellum assembly
CA592_RS04815	COG3328	transposase activity
CA592_RS04835	COG2882	bacterial-type flagellum organization
CA592_RS04840	COG1157	protein secretion by the type III secretion system
CA592_RS04845	COG1317	bacterial-type flagellum organization
CA592_RS04850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CA592_RS04860	COG1766	The M ring may be actively involved in energy transduction
CA592_RS04865	COG1677	Flagellar hook-basal body complex protein FliE
CA592_RS04870	COG1558	bacterial-type flagellum-dependent cell motility
CA592_RS04875	COG1815	bacterial-type flagellum-dependent cell motility
CA592_RS04880	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CA592_RS04885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CA592_RS04890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CA592_RS04895	COG4974	Belongs to the 'phage' integrase family
CA592_RS04900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CA592_RS04905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CA592_RS04910	COG0758	DNA mediated transformation
CA592_RS04915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CA592_RS04920	COG0045	succinate-CoA ligase (ADP-forming) activity
CA592_RS04925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CA592_RS04930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CA592_RS04935	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CA592_RS04945	COG0335	large ribosomal subunit rRNA binding
CA592_RS04950	COG0336	Belongs to the RNA methyltransferase TrmD family
CA592_RS04955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CA592_RS04965	COG1837	Belongs to the UPF0109 family
CA592_RS04970	COG0228	four-way junction DNA binding
CA592_RS04975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CA592_RS04980	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CA592_RS04985	COG0552	protein localization to endoplasmic reticulum
CA592_RS04990	COG1196	nuclear chromosome segregation
CA592_RS05000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CA592_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
CA592_RS05010	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CA592_RS05015	COG0416	fatty acid biosynthetic process
CA592_RS05020	COG1349	DNA-binding transcription factor activity
CA592_RS05025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CA592_RS05030	COG1760	l-serine dehydratase
CA592_RS05035	COG1760	l-serine dehydratase
CA592_RS05040	COG1461	Dihydroxyacetone kinase
CA592_RS05045	COG1302	Protein conserved in bacteria
CA592_RS05050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CA592_RS05060	COG1564	THIamine pyrophosphokinase
CA592_RS05065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CA592_RS05070	COG1162	GTPase activity
CA592_RS05075	COG0515	serine threonine protein kinase
CA592_RS05075	COG2815	serine threonine protein kinase
CA592_RS05080	COG0631	protein serine/threonine phosphatase activity
CA592_RS05085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CA592_RS05090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CA592_RS05090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CA592_RS05095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CA592_RS05100	COG0242	peptide deformylase activity
CA592_RS05105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CA592_RS05110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CA592_RS05115	COG1758	RNA polymerase activity
CA592_RS05120	COG0194	GDP metabolic process
CA592_RS05125	COG1561	YicC-like family, N-terminal region
CA592_RS05130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CA592_RS05190	COG0284	orotidine-5'-phosphate decarboxylase activity
CA592_RS05195	COG0167	dihydroorotate dehydrogenase activity
CA592_RS05200	COG0543	2 iron, 2 sulfur cluster binding
CA592_RS05215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CA592_RS05220	COG0540	Belongs to the ATCase OTCase family
CA592_RS05230	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CA592_RS05235	COG0564	pseudouridine synthase activity
CA592_RS05240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CA592_RS05245	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CA592_RS05250	COG3599	regulation of cell shape
CA592_RS05255	COG2302	S4 RNA-binding domain
CA592_RS05260	COG0762	integral membrane protein
CA592_RS05265	COG1799	cell septum assembly
CA592_RS05270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CA592_RS05280	COG1873	PFAM PRC-barrel domain
CA592_RS05285	COG1191	sigma factor activity
CA592_RS05290	COG1191	sigma factor activity
CA592_RS05300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CA592_RS05305	COG0849	cell division
CA592_RS05310	COG3856	small basic protein
CA592_RS05315	COG3879	Bacterial protein of unknown function (DUF881)
CA592_RS05320	COG3879	Bacterial protein of unknown function (DUF881)
CA592_RS05325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CA592_RS05330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CA592_RS05335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CA592_RS05340	COG0772	Belongs to the SEDS family
CA592_RS05345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CA592_RS05350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CA592_RS05355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CA592_RS05360	COG0768	penicillin binding
CA592_RS05365	COG0768	penicillin binding
CA592_RS05370	COG4839	cell division protein FtsL
CA592_RS05375	COG0275	rRNA processing
CA592_RS05380	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CA592_RS05390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CA592_RS05400	COG1024	Enoyl-CoA hydratase
CA592_RS05405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CA592_RS05410	COG1399	metal-binding, possibly nucleic acid-binding protein
CA592_RS05415	COG1323	Belongs to the UPF0348 family
CA592_RS05420	COG3480	Lon protease (S16) C-terminal proteolytic domain
CA592_RS05425	COG1752	Esterase of the alpha-beta hydrolase superfamily
CA592_RS05430	COG3314	Sporulation integral membrane protein YlbJ
CA592_RS05435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CA592_RS05440	COG0742	ribosomal rna small subunit methyltransferase
CA592_RS05455	COG4471	UPF0298 protein
CA592_RS05460	COG3679	Belongs to the UPF0342 family
CA592_RS05480	COG2340	Cysteine-rich secretory protein family
CA592_RS05485	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CA592_RS05505	COG3336	cytochrome c oxidase
CA592_RS05530	COG0109	protoheme IX farnesyltransferase activity
CA592_RS05535	COG1612	heme a metabolic process
CA592_RS05540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CA592_RS05545	COG0772	Belongs to the SEDS family
CA592_RS05550	COG4838	Belongs to the UPF0358 family
CA592_RS05555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CA592_RS05560	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CA592_RS05575	COG4896	Protein conserved in bacteria
CA592_RS05590	COG1217	gtp-binding protein TYPA
CA592_RS05600	COG0483	inositol monophosphate 1-phosphatase activity
CA592_RS05610	COG4476	Belongs to the UPF0223 family
CA592_RS05620	COG1982	Orn Lys Arg decarboxylase major
CA592_RS05670	COG0561	phosphatase activity
CA592_RS05675	COG5503	Protein of unknown function (DUF1447)
CA592_RS05680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CA592_RS05685	COG0569	domain protein
CA592_RS05690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CA592_RS05695	COG1473	amidohydrolase
CA592_RS05700	COG2171	N-acyltransferase activity
CA592_RS05705	COG0517	IMP dehydrogenase activity
CA592_RS05710	COG4703	Protein of unknown function (DUF1797)
CA592_RS05720	COG2200	EAL domain
CA592_RS05725	COG1028	Short-chain dehydrogenase reductase Sdr
CA592_RS05730	COG1408	metallophosphoesterase
CA592_RS05735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CA592_RS05740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CA592_RS05750	COG0248	Ppx GppA phosphatase
CA592_RS05800	COG0835	chemotaxis
CA592_RS05800	COG0784	Response regulator, receiver
CA592_RS05820	COG0436	Aminotransferase
CA592_RS05825	COG2084	Dehydrogenase
CA592_RS05850	COG1263	PTS System
CA592_RS05850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CA592_RS05850	COG2190	(PTS) system
CA592_RS05855	COG3711	transcriptional antiterminator
CA592_RS05860	COG0561	phosphatase activity
CA592_RS05865	COG3942	CHAP domain
CA592_RS05865	COG1388	LysM domain
CA592_RS05870	COG1320	monovalent cation:proton antiporter activity
CA592_RS05875	COG2212	antiporter activity
CA592_RS05880	COG1863	multisubunit Na H antiporter MnhE subunit
CA592_RS05885	COG0651	ATP synthesis coupled electron transport
CA592_RS05890	COG1006	Multisubunit Na H antiporter MnhC subunit
CA592_RS05895	COG2111	Na H antiporter
CA592_RS05900	COG2111	Na H antiporter
CA592_RS05900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CA592_RS05920	COG1733	regulation of RNA biosynthetic process
CA592_RS05925	COG0778	Nitroreductase
CA592_RS05930	COG4191	Histidine kinase
CA592_RS05955	COG4873	Protein conserved in bacteria
CA592_RS05960	COG0702	epimerase
CA592_RS05965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CA592_RS05975	COG0720	synthase
CA592_RS05980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CA592_RS05985	COG0704	Plays a role in the regulation of phosphate uptake
CA592_RS06000	COG3949	Membrane
CA592_RS06015	COG0745	RESPONSE REGULATOR receiver
CA592_RS06020	COG5002	protein histidine kinase activity
CA592_RS06035	COG0542	response to heat
CA592_RS06045	COG0531	amino acid
CA592_RS06050	COG3852	Histidine kinase
CA592_RS06060	COG0697	spore germination
CA592_RS06065	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CA592_RS06070	COG0235	Class ii aldolase
CA592_RS06075	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CA592_RS06080	COG1850	ribulose-bisphosphate carboxylase activity
CA592_RS06085	COG0436	Aminotransferase
CA592_RS06090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CA592_RS06095	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CA592_RS06100	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CA592_RS06105	COG5002	protein histidine kinase activity
CA592_RS06110	COG1556	Lactate utilization protein
CA592_RS06115	COG1139	Iron-sulfur cluster binding protein
CA592_RS06120	COG0247	lactate metabolic process
CA592_RS06125	COG2186	Transcriptional regulator
CA592_RS06150	COG3835	regulator
CA592_RS06155	COG0277	FAD linked oxidase domain protein
CA592_RS06160	COG0247	lactate metabolic process
CA592_RS06170	COG1528	Iron-storage protein
CA592_RS06180	COG0861	Integral membrane protein TerC family
CA592_RS06185	COG0531	amino acid
CA592_RS06200	COG2814	Major facilitator Superfamily
CA592_RS06210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CA592_RS06220	COG0628	permease
CA592_RS06240	COG5002	protein histidine kinase activity
CA592_RS06250	COG0252	asparaginase activity
CA592_RS06255	COG1396	sequence-specific DNA binding
CA592_RS06260	COG0515	serine threonine protein kinase
CA592_RS06275	COG0586	Pfam SNARE associated Golgi protein
CA592_RS06280	COG0531	amino acid
CA592_RS06285	COG3162	membrane
CA592_RS06290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CA592_RS06340	COG3328	transposase activity
CA592_RS06380	COG0477	Major facilitator Superfamily
CA592_RS06420	COG0640	Transcriptional regulator
CA592_RS06440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CA592_RS06445	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CA592_RS06450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CA592_RS06450	COG1918	ferrous iron import across plasma membrane
CA592_RS06460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CA592_RS06475	COG0367	asparagine synthase
CA592_RS06480	COG4990	cell redox homeostasis
CA592_RS06485	COG2132	Multicopper oxidase
CA592_RS06585	COG4974	Belongs to the 'phage' integrase family
CA592_RS06595	COG1418	mRNA catabolic process
CA592_RS06600	COG0626	cystathionine gamma-synthase activity
CA592_RS06605	COG0626	cystathionine gamma-synthase activity
CA592_RS06610	COG1970	mechanosensitive ion channel activity
CA592_RS06615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CA592_RS06620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CA592_RS06625	COG2153	protein acetylation
CA592_RS06630	COG2323	membrane
CA592_RS06635	COG0210	DNA helicase
CA592_RS06655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CA592_RS06670	COG1476	TRANSCRIPTIONal
CA592_RS06675	COG2323	membrane
CA592_RS06690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CA592_RS06755	COG2239	Acts as a magnesium transporter
CA592_RS06760	COG0772	Belongs to the SEDS family
CA592_RS06765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CA592_RS06770	COG0564	pseudouridine synthase activity
CA592_RS06780	COG2357	RelA SpoT domain protein
CA592_RS06790	COG4116	CYTH
CA592_RS06795	COG0741	lytic transglycosylase activity
CA592_RS06800	COG2346	COG2346, Truncated hemoglobins
CA592_RS06805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CA592_RS06810	COG1164	Oligoendopeptidase f
CA592_RS06820	COG4862	establishment of competence for transformation
CA592_RS06825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CA592_RS06830	COG1393	Belongs to the ArsC family
CA592_RS06840	COG4608	Belongs to the ABC transporter superfamily
CA592_RS06845	COG0444	Belongs to the ABC transporter superfamily
CA592_RS06850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CA592_RS06855	COG0601	transmembrane transport
CA592_RS06860	COG4166	transmembrane transport
CA592_RS06870	COG0180	Tryptophanyl-tRNA synthetase
CA592_RS06885	COG5504	Zn-dependent protease
CA592_RS06890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CA592_RS06895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CA592_RS06900	COG1744	ABC transporter substrate-binding protein PnrA-like
CA592_RS06915	COG0542	response to heat
CA592_RS06925	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CA592_RS06945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CA592_RS06950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CA592_RS06955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CA592_RS06960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CA592_RS06970	COG1073	alpha beta
CA592_RS06975	COG0561	phosphatase activity
CA592_RS06985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CA592_RS06990	COG1307	EDD domain protein, DegV family
CA592_RS07000	COG1666	GTP binding
CA592_RS07005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CA592_RS07005	COG0646	methionine synthase
CA592_RS07010	COG1410	methionine synthase
CA592_RS07010	COG0646	methionine synthase
CA592_RS07015	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CA592_RS07025	COG1492	cobalamin metabolic process
CA592_RS07055	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CA592_RS07080	COG1122	ATPase activity
CA592_RS07090	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
CA592_RS07095	COG0310	cobalt ion transport
CA592_RS07115	COG0366	Alpha amylase catalytic
CA592_RS07115	COG1874	Beta-galactosidase
CA592_RS07120	COG3833	ABC-type maltose transport systems, permease component
CA592_RS07125	COG1175	transmembrane transport
CA592_RS07135	COG1175	transmembrane transport
CA592_RS07140	COG2182	Extracellular solute-binding protein
CA592_RS07150	COG1917	Cupin 2, conserved barrel domain protein
CA592_RS07150	COG2207	Transcriptional regulator
CA592_RS07155	COG0534	Mate efflux family protein
CA592_RS07160	COG0367	asparagine synthase
CA592_RS07205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CA592_RS07210	COG0179	Fumarylacetoacetate (FAA) hydrolase
CA592_RS07225	COG2311	Membrane
CA592_RS07260	COG0601	transmembrane transport
CA592_RS07265	COG4608	Belongs to the ABC transporter superfamily
CA592_RS07315	COG1403	HNH endonuclease
CA592_RS07320	COG0419	ATPase involved in DNA repair
CA592_RS07325	COG0420	3'-5' exonuclease activity
CA592_RS07330	COG1074	ATP-dependent DNA helicase activity
CA592_RS07335	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CA592_RS07340	COG0398	Pfam SNARE associated Golgi protein
CA592_RS07345	COG4903	ComK protein
CA592_RS07350	COG2224	Isocitrate lyase
CA592_RS07355	COG0501	Belongs to the peptidase M48B family
CA592_RS07360	COG1999	signal sequence binding
CA592_RS07365	COG0840	transmembrane signaling receptor activity
CA592_RS07375	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CA592_RS07380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CA592_RS07380	COG1116	anion transmembrane transporter activity
CA592_RS07385	COG4120	Belongs to the binding-protein-dependent transport system permease family
CA592_RS07395	COG0318	PFAM AMP-dependent synthetase and ligase
CA592_RS07405	COG0517	IMP dehydrogenase activity
CA592_RS07405	COG0617	tRNA 3'-terminal CCA addition
CA592_RS07405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CA592_RS07410	COG1234	tRNA 3'-trailer cleavage
CA592_RS07420	COG0366	Alpha amylase catalytic
CA592_RS07425	COG1609	Transcriptional regulator
CA592_RS07430	COG1511	domain protein
CA592_RS07435	COG1309	transcriptional regulator
CA592_RS07440	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CA592_RS07445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CA592_RS07450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CA592_RS07455	COG2329	Antibiotic biosynthesis monooxygenase
CA592_RS07460	COG1473	amidohydrolase
CA592_RS07470	COG1131	(ABC) transporter
CA592_RS07475	COG0537	adenosine 5'-monophosphoramidase activity
CA592_RS07480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CA592_RS07500	COG1846	Transcriptional regulator
CA592_RS07515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CA592_RS07530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CA592_RS07535	COG0561	phosphatase activity
CA592_RS07540	COG3679	Belongs to the UPF0342 family
CA592_RS07545	COG4399	Belongs to the UPF0754 family
CA592_RS07555	COG2508	Transcriptional regulator
CA592_RS07560	COG3842	ATPase activity
CA592_RS07575	COG1126	abc transporter atp-binding protein
CA592_RS07580	COG1253	flavin adenine dinucleotide binding
CA592_RS07585	COG0351	phosphomethylpyrimidine kinase
CA592_RS07590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CA592_RS07605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CA592_RS07610	COG0352	thiamine-phosphate diphosphorylase activity
CA592_RS07615	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CA592_RS07620	COG1122	ATPase activity
CA592_RS07625	COG4721	ABC-type cobalt transport system, permease component
CA592_RS07630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CA592_RS07640	COG0366	Alpha amylase catalytic
CA592_RS07650	COG1846	Transcriptional regulator
CA592_RS07660	COG2719	SpoVR family
CA592_RS07665	COG0330	HflC and HflK could
CA592_RS07670	COG0330	HflC and HflK could
CA592_RS07675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CA592_RS07690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CA592_RS07695	COG0517	IMP dehydrogenase activity
CA592_RS07700	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CA592_RS07705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CA592_RS07715	COG0564	pseudouridine synthase activity
CA592_RS07725	COG2738	Putative neutral zinc metallopeptidase
CA592_RS07730	COG2210	Belongs to the sulfur carrier protein TusA family
CA592_RS07735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CA592_RS07735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CA592_RS07745	COG0730	response to heat
CA592_RS07750	COG0425	Belongs to the sulfur carrier protein TusA family
CA592_RS07755	COG2210	Belongs to the sulfur carrier protein TusA family
CA592_RS07760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CA592_RS07760	COG0425	Belongs to the sulfur carrier protein TusA family
CA592_RS07765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CA592_RS07810	COG2718	Belongs to the UPF0229 family
CA592_RS07815	COG2766	serine protein kinase
CA592_RS07820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CA592_RS07835	COG3382	B3 4 domain protein
CA592_RS07940	COG1285	pathogenesis
CA592_RS07950	COG1253	flavin adenine dinucleotide binding
CA592_RS07955	COG0789	Transcriptional regulator
CA592_RS07970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CA592_RS07985	COG1979	alcohol dehydrogenase
CA592_RS07990	COG2155	Conserved Protein
CA592_RS07995	COG1098	S1 RNA binding domain
CA592_RS08005	COG0436	Aminotransferase
CA592_RS08010	COG1522	sequence-specific DNA binding
CA592_RS08015	COG2032	superoxide dismutase activity
CA592_RS08035	COG1268	BioY protein
CA592_RS08040	COG3584	3D domain protein
CA592_RS08055	COG1252	NADH dehydrogenase
CA592_RS08060	COG0492	ferredoxin-NADP+ reductase activity
CA592_RS08065	COG5416	Lipopolysaccharide assembly protein A domain
CA592_RS08070	COG0316	Belongs to the HesB IscA family
CA592_RS08075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CA592_RS08085	COG4844	belongs to the
CA592_RS08090	COG1252	NADH dehydrogenase
CA592_RS08095	COG4837	Protein of unknown function (DUF1462)
CA592_RS08105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CA592_RS08110	COG0083	homoserine kinase activity
CA592_RS08115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CA592_RS08120	COG0460	homoserine dehydrogenase
CA592_RS08125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CA592_RS08130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CA592_RS08135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CA592_RS08140	COG0647	UMP catabolic process
CA592_RS08150	COG2445	Protein of unknown function DUF86
CA592_RS08170	COG4470	Protein conserved in bacteria
CA592_RS08180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CA592_RS08190	COG0739	heme binding
CA592_RS08200	COG3377	Domain of unknown function (DUF1805)
CA592_RS08205	COG0737	Belongs to the 5'-nucleotidase family
CA592_RS08210	COG0730	response to heat
CA592_RS08215	COG1801	Protein of unknown function DUF72
CA592_RS08220	COG0719	Fe-S assembly protein
CA592_RS08225	COG0822	iron-sulfur transferase activity
CA592_RS08230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CA592_RS08235	COG0719	Fe-S assembly protein
CA592_RS08240	COG0396	ATPase activity
CA592_RS08250	COG1464	Belongs to the NlpA lipoprotein family
CA592_RS08255	COG2011	ABC-type metal ion transport system permease component
CA592_RS08260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CA592_RS08275	COG2873	o-acetylhomoserine
CA592_RS08285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CA592_RS08295	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CA592_RS08305	COG0509	glycine decarboxylation via glycine cleavage system
CA592_RS08310	COG1393	Belongs to the ArsC family
CA592_RS08320	COG1960	acyl-CoA dehydrogenase activity
CA592_RS08325	COG0183	Belongs to the thiolase family
CA592_RS08330	COG1250	3-hydroxyacyl-CoA dehydrogenase
CA592_RS08330	COG1024	Enoyl-CoA hydratase
CA592_RS08340	COG0506	proline dehydrogenase activity
CA592_RS08350	COG5577	PFAM Coat F domain
CA592_RS08365	COG1876	peptidase activity
CA592_RS08370	COG4824	toxin secretion phage lysis holin
CA592_RS08470	COG0582	viral genome integration into host DNA
CA592_RS08475	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CA592_RS08570	COG1396	sequence-specific DNA binding
CA592_RS08575	COG1396	sequence-specific DNA binding
CA592_RS08580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CA592_RS08595	COG2856	Zn peptidase
CA592_RS08600	COG4974	Belongs to the 'phage' integrase family
CA592_RS08610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CA592_RS08615	COG0557	exoribonuclease II activity
CA592_RS08625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CA592_RS08645	COG0148	phosphopyruvate hydratase activity
CA592_RS08650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CA592_RS08655	COG0149	triose-phosphate isomerase activity
CA592_RS08660	COG0126	phosphoglycerate kinase activity
CA592_RS08680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CA592_RS08690	COG0740	serine-type endopeptidase activity
CA592_RS08695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CA592_RS08700	COG1481	regulation of sporulation
CA592_RS08705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CA592_RS08710	COG1660	Displays ATPase and GTPase activities
CA592_RS08715	COG1051	belongs to the nudix hydrolase family
CA592_RS08720	COG0492	ferredoxin-NADP+ reductase activity
CA592_RS08725	COG0457	Tetratricopeptide repeat
CA592_RS08730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CA592_RS08730	COG0140	phosphoribosyl-ATP diphosphatase activity
CA592_RS08735	COG0107	imidazoleglycerol-phosphate synthase activity
CA592_RS08740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CA592_RS08745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CA592_RS08750	COG0131	Imidazoleglycerol-phosphate dehydratase
CA592_RS08755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CA592_RS08760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CA592_RS08765	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CA592_RS08770	COG0110	maltose O-acetyltransferase activity
CA592_RS08775	COG0546	phosphoglycolate phosphatase activity
CA592_RS08780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CA592_RS08785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CA592_RS08790	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CA592_RS08795	COG1950	PFAM Membrane protein of
CA592_RS08810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CA592_RS08815	COG0556	nucleotide-excision repair
CA592_RS08820	COG4897	Protein conserved in bacteria
CA592_RS08825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CA592_RS08830	COG0789	Transcriptional regulator
CA592_RS08835	COG0793	Belongs to the peptidase S41A family
CA592_RS08835	COG3409	Peptidoglycan-binding domain 1 protein
CA592_RS08840	COG0739	heme binding
CA592_RS08845	COG2177	Part of the ABC transporter FtsEX involved in
CA592_RS08850	COG2884	Cell division ATP-binding protein ftsE
CA592_RS08860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CA592_RS08890	COG0653	protein targeting
CA592_RS08920	COG1516	flagellar protein fliS
CA592_RS08925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CA592_RS08930	COG1334	flagellar protein FlaG
CA592_RS08965	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CA592_RS08970	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CA592_RS08980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CA592_RS08985	COG1256	bacterial-type flagellum assembly
CA592_RS08985	COG4786	Flagellar basal body rod
CA592_RS09005	COG1728	Protein conserved in bacteria
CA592_RS09010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CA592_RS09025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CA592_RS09035	COG2257	FlhB HrpN YscU SpaS Family
CA592_RS09045	COG1040	competence protein
CA592_RS09050	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CA592_RS09055	COG1307	EDD domain protein, DegV family
CA592_RS09060	COG2197	response regulator
CA592_RS09065	COG4585	Histidine kinase
CA592_RS09070	COG1739	Uncharacterized protein family UPF0029
CA592_RS09075	COG1316	TRANSCRIPTIONal
CA592_RS09080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CA592_RS09090	COG2385	sporulation resulting in formation of a cellular spore
CA592_RS09090	COG2247	cell wall binding repeat
CA592_RS09095	COG2911	Protein conserved in bacteria
CA592_RS09095	COG3266	domain, Protein
CA592_RS09095	COG1361	Conserved repeat domain
CA592_RS09105	COG1404	Belongs to the peptidase S8 family
CA592_RS09110	COG0737	Belongs to the 5'-nucleotidase family
CA592_RS09140	COG0606	chelatase, subunit chli
CA592_RS09150	COG3620	sequence-specific DNA binding
CA592_RS09180	COG2003	Belongs to the UPF0758 family
CA592_RS09185	COG0860	N-Acetylmuramoyl-L-alanine amidase
CA592_RS09190	COG0791	NLP P60 protein
CA592_RS09190	COG1388	LysM domain
CA592_RS09200	COG1404	Belongs to the peptidase S8 family
CA592_RS09205	COG0653	protein targeting
CA592_RS09225	COG1396	sequence-specific DNA binding
CA592_RS09240	COG3764	Sortase (surface protein transpeptidase)
CA592_RS09250	COG0527	aspartate kinase activity
CA592_RS09260	COG4903	ComK protein
CA592_RS09275	COG2244	polysaccharide biosynthetic process
CA592_RS09290	COG1361	Conserved repeat domain
CA592_RS09290	COG2911	Protein conserved in bacteria
CA592_RS09290	COG3266	domain, Protein
CA592_RS09300	COG1405	negative regulation of cell septum assembly
CA592_RS09300	COG3012	SEC-C Motif Domain Protein
CA592_RS09305	COG2996	Protein conserved in bacteria
CA592_RS09310	COG0673	inositol 2-dehydrogenase activity
CA592_RS09320	COG3177	Filamentation induced by cAMP protein fic
CA592_RS09330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CA592_RS09335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CA592_RS09345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CA592_RS09350	COG3012	SEC-C Motif Domain Protein
CA592_RS09390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CA592_RS09410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CA592_RS09435	COG1940	carbohydrate kinase activity
CA592_RS09440	COG1482	cell wall glycoprotein biosynthetic process
CA592_RS09445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CA592_RS09445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CA592_RS09445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CA592_RS09450	COG3711	transcriptional antiterminator
CA592_RS09450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CA592_RS09455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CA592_RS09455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CA592_RS09455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CA592_RS09460	COG0346	lactoylglutathione lyase activity
CA592_RS09465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CA592_RS09475	COG0662	Cupin 2, conserved barrel domain protein
CA592_RS09475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CA592_RS09515	COG1091	dTDP-4-dehydrorhamnose reductase activity
CA592_RS09555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CA592_RS09565	COG4464	protein tyrosine phosphatase activity
CA592_RS09570	COG0489	protein tyrosine kinase activity
CA592_RS09575	COG3944	biosynthesis protein
CA592_RS09590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CA592_RS09615	COG4786	Flagellar basal body rod
CA592_RS09620	COG4786	Flagellar basal body rod
CA592_RS09625	COG1077	Cell shape determining protein MreB Mrl
CA592_RS09630	COG1609	Transcriptional regulator
CA592_RS09635	COG0739	heme binding
CA592_RS09640	COG2385	sporulation resulting in formation of a cellular spore
CA592_RS09645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CA592_RS09655	COG4836	Membrane
CA592_RS09660	COG1007	ATP synthesis coupled electron transport
CA592_RS09670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CA592_RS09675	COG0713	ATP synthesis coupled electron transport
CA592_RS09680	COG0839	Belongs to the complex I subunit 6 family
CA592_RS09685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CA592_RS09690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CA592_RS09695	COG0649	NAD binding
CA592_RS09700	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CA592_RS09705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CA592_RS09710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CA592_RS09715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CA592_RS09720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CA592_RS09725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CA592_RS09730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CA592_RS09735	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CA592_RS09740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CA592_RS09745	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CA592_RS09750	COG0356	it plays a direct role in the translocation of protons across the membrane
CA592_RS09765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CA592_RS09770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CA592_RS09775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CA592_RS09780	COG4475	Protein of unknown function (DUF436)
CA592_RS09785	COG0698	ribose 5-phosphate isomerase
CA592_RS09790	COG0840	transmembrane signaling receptor activity
CA592_RS09800	COG1971	Probably functions as a manganese efflux pump
CA592_RS09805	COG0009	L-threonylcarbamoyladenylate synthase
CA592_RS09820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CA592_RS09830	COG1012	belongs to the aldehyde dehydrogenase family
CA592_RS09855	COG1435	thymidine kinase activity
CA592_RS09860	COG0254	rRNA binding
CA592_RS09865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CA592_RS09870	COG1494	fructose-1,6-bisphosphatase
CA592_RS09875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CA592_RS09880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CA592_RS09890	COG2204	response regulator
CA592_RS09900	COG4821	SIS domain
CA592_RS09905	COG0504	CTP synthase activity
CA592_RS09910	COG3343	RNA polymerase activity
CA592_RS09925	COG1960	acyl-CoA dehydrogenase activity
CA592_RS09930	COG1960	acyl-CoA dehydrogenase activity
CA592_RS09935	COG1250	3-hydroxyacyl-CoA dehydrogenase
CA592_RS09940	COG0183	Belongs to the thiolase family
CA592_RS09945	COG0247	lactate metabolic process
CA592_RS09945	COG2181	nitrate reductase activity
CA592_RS09955	COG0018	arginyl-trna synthetase
CA592_RS09985	COG0010	Belongs to the arginase family
CA592_RS09995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CA592_RS10000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CA592_RS10010	COG1994	Peptidase M50
CA592_RS10020	COG3465	dGTPase activity
CA592_RS10025	COG1078	dGTPase activity
CA592_RS10030	COG4844	belongs to the
CA592_RS10045	COG0095	Lipoate-protein ligase
CA592_RS10050	COG0280	phosphate acetyltransferase
CA592_RS10055	COG1238	metal cluster binding
CA592_RS10065	COG3773	Cell wall hydrolase
CA592_RS10075	COG2363	Small membrane protein
CA592_RS10095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CA592_RS10105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CA592_RS10110	COG0423	glycine-tRNA ligase activity
CA592_RS10115	COG3634	alkyl hydroperoxide reductase activity
CA592_RS10120	COG0450	alkyl hydroperoxide reductase
CA592_RS10125	COG1216	Glycosyl transferase, family 2
CA592_RS10130	COG0477	Major facilitator Superfamily
CA592_RS10135	COG0295	cytidine deaminase activity
CA592_RS10145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CA592_RS10150	COG2390	Transcriptional regulator
CA592_RS10160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CA592_RS10165	COG2508	Transcriptional regulator
CA592_RS10165	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CA592_RS10170	COG0686	Belongs to the AlaDH PNT family
CA592_RS10180	COG0765	amino acid transport
CA592_RS10190	COG1882	Formate acetyltransferase
CA592_RS10195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CA592_RS10200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CA592_RS10205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CA592_RS10210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CA592_RS10220	COG1595	DNA-templated transcription, initiation
CA592_RS10235	COG1136	(ABC) transporter
CA592_RS10235	COG0577	efflux transmembrane transporter activity
CA592_RS10270	COG4585	Histidine kinase
CA592_RS10285	COG1454	alcohol dehydrogenase
CA592_RS10285	COG1012	belongs to the aldehyde dehydrogenase family
CA592_RS10300	COG0723	plastoquinol--plastocyanin reductase activity
CA592_RS10300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CA592_RS10305	COG3842	ATPase activity
CA592_RS10310	COG1176	ABC-type spermidine putrescine transport system, permease component I
CA592_RS10315	COG1177	transmembrane transport
CA592_RS10320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CA592_RS10325	COG3104	oligopeptide transport
CA592_RS10340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CA592_RS10345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CA592_RS10360	COG5002	protein histidine kinase activity
CA592_RS10365	COG0745	RESPONSE REGULATOR receiver
CA592_RS10380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CA592_RS10385	COG0305	Participates in initiation and elongation during chromosome replication
CA592_RS10390	COG0359	binds to the 23S rRNA
CA592_RS10395	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CA592_RS10400	COG4241	membrane
CA592_RS10405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CA592_RS10410	COG0629	single-stranded DNA binding
CA592_RS10415	COG0360	Binds together with S18 to 16S ribosomal RNA
CA592_RS10420	COG0012	GTP binding
CA592_RS10425	COG4481	Protein conserved in bacteria
CA592_RS10430	COG0668	transmembrane transport
CA592_RS10440	COG1811	Na channel or pump
CA592_RS10445	COG1475	DNA binding
CA592_RS10450	COG1192	Involved in chromosome partitioning
CA592_RS10455	COG1475	DNA binding
CA592_RS10460	COG0357	Ribosomal RNA small subunit methyltransferase G
CA592_RS10465	COG0445	tRNA wobble uridine modification
CA592_RS10470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CA592_RS10475	COG1847	R3H domain protein
CA592_RS10480	COG0706	membrane insertase activity
CA592_RS10485	COG0594	ribonuclease P activity
CA592_RS10490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CA592_RS10495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CA592_RS10500	COG0592	DNA-directed DNA polymerase activity
CA592_RS10505	COG2501	S4 domain
CA592_RS10510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CA592_RS10515	COG0187	DNA topoisomerase II activity
CA592_RS10520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CA592_RS10560	COG0516	GMP reductase activity
CA592_RS10560	COG0517	IMP dehydrogenase activity
CA592_RS10570	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CA592_RS10575	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CA592_RS10595	COG1428	Deoxynucleoside kinase
CA592_RS10600	COG1428	Deoxynucleoside kinase
CA592_RS10615	COG0590	tRNA wobble adenosine to inosine editing
CA592_RS10625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CA592_RS10630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CA592_RS10635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CA592_RS10680	COG1982	Orn Lys Arg decarboxylase major
CA592_RS10685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CA592_RS10690	COG0470	DNA polymerase III
CA592_RS10695	COG1774	PSP1 C-terminal conserved region
CA592_RS10700	COG4467	Involved in initiation control of chromosome replication
CA592_RS10705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CA592_RS10710	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CA592_RS10715	COG2002	toxin-antitoxin pair type II binding
CA592_RS10725	COG0084	hydrolase, TatD family'
CA592_RS10730	COG3583	domain protein
CA592_RS10730	COG3584	3D domain protein
CA592_RS10740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CA592_RS10750	COG4466	Protein conserved in bacteria
CA592_RS10755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CA592_RS10760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CA592_RS10765	COG0251	oxidation-reduction process
CA592_RS10770	COG2088	sporulation resulting in formation of a cellular spore
CA592_RS10775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CA592_RS10785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CA592_RS10790	COG0193	aminoacyl-tRNA hydrolase activity
CA592_RS10800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CA592_RS10805	COG2002	toxin-antitoxin pair type II binding
CA592_RS10810	COG2244	polysaccharide biosynthetic process
CA592_RS10815	COG3956	TIGRFAM MazG family protein
CA592_RS10820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CA592_RS10835	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CA592_RS10840	COG1098	S1 RNA binding domain
CA592_RS10855	COG2208	phosphoserine phosphatase activity
CA592_RS10860	COG2304	oxidoreductase activity
CA592_RS10865	COG0515	serine threonine protein kinase
CA592_RS10870	COG0037	tRNA processing
CA592_RS10875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CA592_RS10880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CA592_RS10885	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CA592_RS10895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CA592_RS10900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CA592_RS10905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CA592_RS10910	COG0512	Glutamine amidotransferase of anthranilate synthase
CA592_RS10915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CA592_RS10920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CA592_RS10925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CA592_RS10930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CA592_RS10935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CA592_RS10965	COG0544	peptidyl-prolyl cis-trans isomerase activity
CA592_RS11015	COG3880	PFAM UvrB UvrC protein
CA592_RS11020	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CA592_RS11025	COG0542	response to heat
CA592_RS11030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CA592_RS11035	COG4956	integral membrane protein (PIN domain superfamily)
CA592_RS11040	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CA592_RS11045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CA592_RS11050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CA592_RS11055	COG1045	serine acetyltransferase
CA592_RS11060	COG0215	cysteine-tRNA ligase activity
CA592_RS11065	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CA592_RS11070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CA592_RS11075	COG3688	RNA-binding protein containing a PIN domain
CA592_RS11085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CA592_RS11090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CA592_RS11095	COG0250	Participates in transcription elongation, termination and antitermination
CA592_RS11105	COG0081	regulation of translation
CA592_RS11110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CA592_RS11115	COG0222	ribosome binding
CA592_RS11120	COG2813	Specifically methylates the guanine in position
CA592_RS11125	COG0085	RNA polymerase activity
CA592_RS11130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CA592_RS11135	COG1358	cellular component organization or biogenesis
CA592_RS11140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CA592_RS11145	COG0049	tRNA binding
CA592_RS11150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CA592_RS11155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CA592_RS11160	COG0051	transcription antitermination factor activity, RNA binding
CA592_RS11165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CA592_RS11170	COG0088	Forms part of the polypeptide exit tunnel
CA592_RS11175	COG0089	rRNA binding
CA592_RS11180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CA592_RS11185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CA592_RS11190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CA592_RS11195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CA592_RS11200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CA592_RS11210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CA592_RS11215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CA592_RS11220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CA592_RS11225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CA592_RS11230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CA592_RS11235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CA592_RS11240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CA592_RS11245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CA592_RS11250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CA592_RS11255	COG1841	ribosomal large subunit assembly
CA592_RS11260	COG0200	Binds to the 23S rRNA
CA592_RS11265	COG0201	protein transport
CA592_RS11270	COG0563	adenylate kinase activity
CA592_RS11275	COG0024	Methionine aminopeptidase
CA592_RS11280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CA592_RS11285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CA592_RS11290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CA592_RS11295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CA592_RS11300	COG0202	RNA polymerase activity
CA592_RS11305	COG0203	ribosomal protein L17
CA592_RS11310	COG1122	ATPase activity
CA592_RS11315	COG1122	ATPase activity
CA592_RS11320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CA592_RS11325	COG0101	tRNA pseudouridine synthase activity
CA592_RS11330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CA592_RS11335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CA592_RS11345	COG0860	N-Acetylmuramoyl-L-alanine amidase
CA592_RS11350	COG0489	protein tyrosine kinase activity
CA592_RS11360	COG2194	sulfuric ester hydrolase activity
CA592_RS11365	COG0726	polysaccharide deacetylase
CA592_RS11445	COG1595	DNA-templated transcription, initiation
CA592_RS11450	COG5662	AntiSigma factor
CA592_RS11455	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CA592_RS11460	COG4856	YbbR-like protein
CA592_RS11465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CA592_RS11470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CA592_RS11480	COG3328	transposase activity
CA592_RS11490	COG1131	(ABC) transporter
CA592_RS11515	COG0492	ferredoxin-NADP+ reductase activity
CA592_RS11530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CA592_RS11545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CA592_RS11570	COG1181	Belongs to the D-alanine--D-alanine ligase family
CA592_RS11575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CA592_RS11580	COG0513	Belongs to the DEAD box helicase family
CA592_RS11585	COG0736	holo-[acyl-carrier-protein] synthase activity
CA592_RS11590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CA592_RS11595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CA592_RS11605	COG0864	Transcriptional regulator
CA592_RS11610	COG2337	Toxic component of a toxin-antitoxin (TA) module
CA592_RS11615	COG2183	response to ionizing radiation
CA592_RS11625	COG3091	SprT-like family
CA592_RS11665	COG0544	peptidyl-prolyl cis-trans isomerase activity
CA592_RS11710	COG0802	atpase or kinase
CA592_RS11715	COG1214	PFAM Peptidase M22, glycoprotease
CA592_RS11720	COG0456	acetyltransferase
CA592_RS11725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CA592_RS11740	COG0488	(ABC) transporter
CA592_RS11745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CA592_RS11755	COG1266	CAAX protease self-immunity
CA592_RS11760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CA592_RS11765	COG0459	protein refolding
CA592_RS11780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CA592_RS11780	COG0519	Catalyzes the synthesis of GMP from XMP
CA592_RS11785	COG2252	PERMEase
CA592_RS11810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CA592_RS11815	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CA592_RS11820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CA592_RS11825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CA592_RS11830	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CA592_RS11835	COG0047	phosphoribosylformylglycinamidine synthase activity
CA592_RS11840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CA592_RS11845	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CA592_RS11850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CA592_RS11855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CA592_RS11860	COG0138	bifunctional purine biosynthesis protein purh
CA592_RS11865	COG0151	Belongs to the GarS family
CA592_RS11875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CA592_RS11880	COG1470	cell adhesion involved in biofilm formation
CA592_RS11885	COG4496	protein, YerC YecD
CA592_RS11890	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CA592_RS11905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CA592_RS11910	COG4851	CamS sex pheromone cAM373 precursor
CA592_RS11915	COG1012	belongs to the aldehyde dehydrogenase family
CA592_RS11930	COG3335	DDE superfamily endonuclease
CA592_RS12000	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CA592_RS12010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CA592_RS12015	COG0154	amidase activity
CA592_RS12020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CA592_RS12040	COG5002	protein histidine kinase activity
CA592_RS12060	COG1131	(ABC) transporter
CA592_RS12095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CA592_RS12190	COG3344	reverse transcriptase
CA592_RS12205	COG2801	Transposase and inactivated derivatives
CA592_RS12230	COG1131	(ABC) transporter
CA592_RS12250	COG3328	transposase activity
CA592_RS12260	COG1301	dicarboxylic acid transport
CA592_RS12275	COG1823	symporter activity
CA592_RS12280	COG1595	DNA-templated transcription, initiation
CA592_RS12325	COG1842	Phage shock protein A
CA592_RS12340	COG5002	protein histidine kinase activity
CA592_RS12350	COG1597	lipid kinase activity
CA592_RS12355	COG1595	DNA-templated transcription, initiation
CA592_RS12390	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CA592_RS12395	COG0732	type I restriction modification DNA specificity domain
CA592_RS12400	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CA592_RS12425	COG1620	l-lactate permease
CA592_RS12435	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CA592_RS12450	COG0861	Integral membrane protein TerC family
CA592_RS12455	COG2210	Belongs to the sulfur carrier protein TusA family
CA592_RS12465	COG0010	Belongs to the arginase family
CA592_RS12490	COG1254	Belongs to the acylphosphatase family
CA592_RS12495	COG1648	precorrin-2 dehydrogenase activity
CA592_RS12510	COG0529	Catalyzes the synthesis of activated sulfate
CA592_RS12515	COG2046	Belongs to the sulfate adenylyltransferase family
CA592_RS12520	COG0306	phosphate transporter
CA592_RS12525	COG0175	sulfate reduction
CA592_RS12540	COG4840	Belongs to the UPF0435 family
CA592_RS12545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CA592_RS12555	COG1295	ribonuclease BN
CA592_RS12565	COG0477	Major facilitator Superfamily
CA592_RS12575	COG0387	Pfam Sodium calcium exchanger
CA592_RS12585	COG0535	radical SAM domain protein
CA592_RS12605	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CA592_RS12670	COG3335	DDE superfamily endonuclease
CA592_RS12685	COG4988	ABC transporter
CA592_RS12690	COG3328	transposase activity
CA592_RS12695	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CA592_RS12720	COG2337	Toxic component of a toxin-antitoxin (TA) module
CA592_RS12725	COG2336	PFAM SpoVT AbrB
CA592_RS12750	COG3654	unkown
CA592_RS12780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CA592_RS12810	COG1090	epimerase
CA592_RS12820	COG2137	regulation of response to DNA damage stimulus
CA592_RS12845	COG1988	membrane-bound metal-dependent
CA592_RS12865	COG3557	Belongs to the UPF0374 family
CA592_RS12870	COG4129	membrane
CA592_RS12875	COG0070	glutamate synthase
CA592_RS12875	COG0067	glutamate synthase
CA592_RS12875	COG0069	glutamate synthase activity
CA592_RS12885	COG4555	ABC transporter
CA592_RS12915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CA592_RS12920	COG0735	belongs to the Fur family
CA592_RS13005	COG0544	peptidyl-prolyl cis-trans isomerase activity
CA592_RS13095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CA592_RS13100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CA592_RS13105	COG0297	glycogen (starch) synthase activity
CA592_RS13110	COG0058	SHG alpha-glucan phosphorylase activity
CA592_RS13115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CA592_RS13120	COG1575	Belongs to the MenA family. Type 1 subfamily
CA592_RS13125	COG1169	isochorismate synthase
CA592_RS13130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CA592_RS13135	COG0596	Alpha beta hydrolase
CA592_RS13140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CA592_RS13145	COG0318	PFAM AMP-dependent synthetase and ligase
CA592_RS13150	COG1294	oxidase, subunit
CA592_RS13155	COG1271	oxidase subunit
CA592_RS13185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CA592_RS13190	COG0716	FMN binding
CA592_RS13200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CA592_RS13205	COG3443	Belongs to the bacterial solute-binding protein 9 family
CA592_RS13205	COG0803	Belongs to the bacterial solute-binding protein 9 family
CA592_RS13210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CA592_RS13215	COG1854	S-ribosylhomocysteine lyase activity
CA592_RS13220	COG0783	Belongs to the Dps family
CA592_RS13230	COG0494	nUDIX hydrolase
CA592_RS13235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CA592_RS13240	COG1116	anion transmembrane transporter activity
CA592_RS13245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CA592_RS13260	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CA592_RS13265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CA592_RS13280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CA592_RS13285	COG2267	carboxylic ester hydrolase activity
CA592_RS13295	COG4636	protein conserved in cyanobacteria
CA592_RS13300	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CA592_RS13305	COG1242	4 iron, 4 sulfur cluster binding
CA592_RS13345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CA592_RS13360	COG0412	Dienelactone hydrolase
CA592_RS13365	COG2814	Major facilitator Superfamily
CA592_RS13375	COG0495	leucyl-tRNA aminoacylation
CA592_RS13380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CA592_RS13385	COG2081	HI0933 family
CA592_RS13390	COG2244	polysaccharide biosynthetic process
CA592_RS13400	COG1187	pseudouridine synthase activity
CA592_RS13405	COG1349	DNA-binding transcription factor activity
CA592_RS13410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CA592_RS13425	COG1380	Effector of murein hydrolase LrgA
CA592_RS13430	COG1346	cytolysis
CA592_RS13440	COG1523	belongs to the glycosyl hydrolase 13 family
CA592_RS13445	COG0510	thiamine kinase activity
CA592_RS13455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CA592_RS13460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CA592_RS13470	COG1363	Peptidase, m42
CA592_RS13475	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CA592_RS13480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CA592_RS13485	COG4848	Belongs to the UPF0354 family
CA592_RS13490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CA592_RS13495	COG1674	ftsk spoiiie
CA592_RS13495	COG1674	ftsk spoiiie
CA592_RS13505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CA592_RS13510	COG3118	belongs to the thioredoxin family
CA592_RS13515	COG4980	gas vesicle protein
CA592_RS13520	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CA592_RS13525	COG2309	aminopeptidase activity
CA592_RS13535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CA592_RS13535	COG1605	Chorismate mutase
CA592_RS13545	COG0123	including yeast histone deacetylase and acetoin utilization protein
CA592_RS13550	COG0517	IMP dehydrogenase activity
CA592_RS13555	COG0454	-acetyltransferase
CA592_RS13560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CA592_RS13575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CA592_RS13580	COG2199	diguanylate cyclase activity
CA592_RS13580	COG2203	Gaf domain
CA592_RS13585	COG1956	GAF domain-containing protein
CA592_RS13590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CA592_RS13595	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CA592_RS13600	COG1114	Component of the transport system for branched-chain amino acids
CA592_RS13605	COG1104	cysteine desulfurase activity
CA592_RS13610	COG0301	tRNA thio-modification
CA592_RS13680	COG0010	Belongs to the arginase family
CA592_RS13710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CA592_RS13720	COG3874	Sporulation protein YtfJ
CA592_RS13725	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CA592_RS13730	COG0827	DNA restriction-modification system
CA592_RS13735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CA592_RS13745	COG0137	argininosuccinate synthase activity
CA592_RS13750	COG0165	Argininosuccinate lyase
CA592_RS13760	COG0165	Argininosuccinate lyase
CA592_RS13765	COG0589	response to stress
CA592_RS13770	COG1028	Short-chain dehydrogenase reductase Sdr
CA592_RS13775	COG0006	proline dipeptidase activity
CA592_RS13785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CA592_RS13790	COG4109	DRTGG domain
CA592_RS13800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CA592_RS13815	COG0587	DNA-directed DNA polymerase activity
CA592_RS13820	COG0281	malic enzyme
CA592_RS13835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CA592_RS13840	COG0825	malonyl-CoA metabolic process
CA592_RS13845	COG0205	6-phosphofructokinase activity
CA592_RS13855	COG3030	protein affecting phage T7 exclusion by the F plasmid
CA592_RS13860	COG0628	permease
CA592_RS13865	COG2707	UPF0756 membrane protein
CA592_RS13875	COG0372	Belongs to the citrate synthase family
CA592_RS13880	COG0538	isocitrate dehydrogenase activity
CA592_RS13885	COG0039	L-malate dehydrogenase activity
CA592_RS13890	COG0745	RESPONSE REGULATOR receiver
CA592_RS13895	COG5002	protein histidine kinase activity
CA592_RS13905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CA592_RS13910	COG1971	Probably functions as a manganese efflux pump
CA592_RS13920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CA592_RS13925	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CA592_RS13935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CA592_RS13940	COG3611	Membrane attachment protein
CA592_RS13945	COG1484	DNA-dependent DNA replication
CA592_RS13955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CA592_RS13965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CA592_RS13970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CA592_RS13980	COG1363	Peptidase, m42
CA592_RS13985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CA592_RS13990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CA592_RS13995	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CA592_RS14015	COG3250	beta-galactosidase activity
CA592_RS14025	COG1874	Beta-galactosidase
CA592_RS14030	COG1609	Transcriptional regulator
CA592_RS14045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CA592_RS14050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CA592_RS14055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CA592_RS14060	COG0072	phenylalanine-tRNA ligase activity
CA592_RS14060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CA592_RS14085	COG2197	response regulator
CA592_RS14110	COG1131	(ABC) transporter
CA592_RS14130	COG1033	growth of symbiont in host cell
CA592_RS14130	COG2409	Drug exporters of the RND superfamily
CA592_RS14135	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CA592_RS14140	COG1286	toxin biosynthetic process
CA592_RS14145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CA592_RS14145	COG1796	DNA polymerase
CA592_RS14150	COG1193	negative regulation of DNA recombination
CA592_RS14155	COG3766	membrane
CA592_RS14165	COG0318	PFAM AMP-dependent synthetase and ligase
CA592_RS14170	COG1309	transcriptional regulator
CA592_RS14175	COG1024	Enoyl-CoA hydratase
CA592_RS14180	COG2086	electron transfer activity
CA592_RS14185	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CA592_RS14190	COG3118	belongs to the thioredoxin family
CA592_RS14205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CA592_RS14220	COG0463	Glycosyl transferase, family 2
CA592_RS14245	COG0322	excinuclease ABC activity
CA592_RS14250	COG1719	4-vinyl reductase, 4VR
CA592_RS14255	COG2009	succinate dehydrogenase
CA592_RS14260	COG1053	succinate dehydrogenase
CA592_RS14265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CA592_RS14270	COG0824	Thioesterase
CA592_RS14275	COG2197	response regulator
CA592_RS14280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CA592_RS14285	COG5401	PFAM Sporulation and spore germination
CA592_RS14290	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CA592_RS14295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CA592_RS14300	COG0622	Phosphoesterase
CA592_RS14310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CA592_RS14315	COG0028	Belongs to the TPP enzyme family
CA592_RS14320	COG0440	acetolactate synthase activity
CA592_RS14325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CA592_RS14330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CA592_RS14335	COG0473	3-isopropylmalate dehydrogenase activity
CA592_RS14340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CA592_RS14345	COG0066	3-isopropylmalate dehydratase activity
CA592_RS14355	COG0544	peptidyl-prolyl cis-trans isomerase activity
CA592_RS14360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CA592_RS14365	COG1067	ATP-dependent peptidase activity
CA592_RS14365	COG0470	DNA polymerase III
CA592_RS14375	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CA592_RS14390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CA592_RS14395	COG0181	hydroxymethylbilane synthase activity
CA592_RS14400	COG1587	Uroporphyrinogen-III synthase
CA592_RS14405	COG0113	porphobilinogen synthase activity
CA592_RS14410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CA592_RS14415	COG1388	LysM domain
CA592_RS14415	COG1388	LysM domain
CA592_RS14420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CA592_RS14430	COG0525	valine-tRNA ligase activity
CA592_RS14435	COG0285	dihydrofolate synthase activity
CA592_RS14465	COG0085	RNA polymerase activity
CA592_RS14475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CA592_RS14485	COG1459	type II secretion system
CA592_RS14490	COG4969	Belongs to the N-Me-Phe pilin family
CA592_RS14495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CA592_RS14530	COG2003	Belongs to the UPF0758 family
CA592_RS14535	COG1077	Cell shape determining protein MreB Mrl
CA592_RS14540	COG1792	Involved in formation and maintenance of cell shape
CA592_RS14550	COG0850	regulation of cytokinetic process
CA592_RS14555	COG2894	cell division
CA592_RS14560	COG0739	heme binding
CA592_RS14565	COG1994	Peptidase M50
CA592_RS14570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CA592_RS14575	COG2868	ribosomal protein
CA592_RS14580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CA592_RS14585	COG3290	protein histidine kinase activity
CA592_RS14590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CA592_RS14595	COG4492	Belongs to the UPF0735 family
CA592_RS14600	COG0077	Prephenate dehydratase
CA592_RS14605	COG1827	regulation of RNA biosynthetic process
CA592_RS14610	COG1104	cysteine desulfurase activity
CA592_RS14615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CA592_RS14620	COG0157	Belongs to the NadC ModD family
CA592_RS14625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CA592_RS14630	COG1388	LysM domain
CA592_RS14635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CA592_RS14645	COG0217	transcriptional regulatory protein
CA592_RS14655	COG0632	four-way junction helicase activity
CA592_RS14660	COG2255	four-way junction helicase activity
CA592_RS14670	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CA592_RS14675	COG0343	queuine tRNA-ribosyltransferase activity
CA592_RS14680	COG1862	Preprotein translocase
CA592_RS14690	COG2323	membrane
CA592_RS14695	COG2244	polysaccharide biosynthetic process
CA592_RS14705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CA592_RS14705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CA592_RS14710	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CA592_RS14715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CA592_RS14715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CA592_RS14720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CA592_RS14725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CA592_RS14730	COG1490	D-aminoacyl-tRNA deacylase activity
CA592_RS14735	COG0860	N-Acetylmuramoyl-L-alanine amidase
CA592_RS14740	COG0124	histidyl-tRNA synthetase
CA592_RS14745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CA592_RS14755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CA592_RS14760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CA592_RS14765	COG1309	transcriptional regulator
CA592_RS14770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CA592_RS14775	COG1959	2 iron, 2 sulfur cluster binding
CA592_RS14780	COG1104	cysteine desulfurase activity
CA592_RS14785	COG0482	sulfurtransferase activity
CA592_RS14795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CA592_RS14810	COG0628	permease
CA592_RS14815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CA592_RS14820	COG4472	Bacterial protein of unknown function (DUF965)
CA592_RS14825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CA592_RS14830	COG3906	Belongs to the UPF0473 family
CA592_RS14835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CA592_RS14840	COG4122	O-methyltransferase activity
CA592_RS14850	COG0826	peptidase U32
CA592_RS14855	COG0826	peptidase U32
CA592_RS14860	COG0572	uridine kinase
CA592_RS14865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CA592_RS14870	COG0768	penicillin binding
CA592_RS14885	COG2226	methyltransferase
CA592_RS14890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CA592_RS14900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CA592_RS14905	COG0626	cystathionine gamma-synthase activity
CA592_RS14950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CA592_RS15015	COG0322	excinuclease ABC activity
CA592_RS15020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CA592_RS15045	COG3335	DDE superfamily endonuclease
CA592_RS15050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CA592_RS15060	COG1120	ATPase activity
CA592_RS15065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily