locus-tag	class	description
AF2641_RS00005	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AF2641_RS00040	COG0840	transmembrane signaling receptor activity
AF2641_RS00050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AF2641_RS00050	COG1116	anion transmembrane transporter activity
AF2641_RS00055	COG4120	Belongs to the binding-protein-dependent transport system permease family
AF2641_RS00065	COG0318	PFAM AMP-dependent synthetase and ligase
AF2641_RS00145	COG3209	COG3209 Rhs family protein
AF2641_RS00175	COG0517	IMP dehydrogenase activity
AF2641_RS00175	COG0617	tRNA 3'-terminal CCA addition
AF2641_RS00175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AF2641_RS00180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AF2641_RS00195	COG1234	tRNA 3'-trailer cleavage
AF2641_RS00205	COG0366	Alpha amylase catalytic
AF2641_RS00220	COG1653	transport
AF2641_RS00225	COG1609	Transcriptional regulator
AF2641_RS00230	COG1511	domain protein
AF2641_RS00235	COG1309	transcriptional regulator
AF2641_RS00240	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AF2641_RS00245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AF2641_RS00250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AF2641_RS00255	COG2329	Antibiotic biosynthesis monooxygenase
AF2641_RS00260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF2641_RS00265	COG1473	amidohydrolase
AF2641_RS00275	COG1131	(ABC) transporter
AF2641_RS00280	COG0537	adenosine 5'-monophosphoramidase activity
AF2641_RS00285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AF2641_RS00305	COG1846	Transcriptional regulator
AF2641_RS00325	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AF2641_RS00340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AF2641_RS00345	COG0561	phosphatase activity
AF2641_RS00350	COG3679	Belongs to the UPF0342 family
AF2641_RS00355	COG4399	Belongs to the UPF0754 family
AF2641_RS00365	COG2508	Transcriptional regulator
AF2641_RS00370	COG3842	ATPase activity
AF2641_RS00385	COG1126	abc transporter atp-binding protein
AF2641_RS00390	COG0765	amino acid transport
AF2641_RS00395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AF2641_RS00400	COG1253	flavin adenine dinucleotide binding
AF2641_RS00405	COG0351	phosphomethylpyrimidine kinase
AF2641_RS00410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AF2641_RS00415	COG2022	thiamine diphosphate biosynthetic process
AF2641_RS00425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AF2641_RS00430	COG0352	thiamine-phosphate diphosphorylase activity
AF2641_RS00435	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AF2641_RS00440	COG1122	ATPase activity
AF2641_RS00445	COG4721	ABC-type cobalt transport system, permease component
AF2641_RS00450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AF2641_RS00465	COG0366	Alpha amylase catalytic
AF2641_RS00470	COG0477	Major facilitator Superfamily
AF2641_RS00475	COG1846	Transcriptional regulator
AF2641_RS00480	COG2719	SpoVR family
AF2641_RS00485	COG0330	HflC and HflK could
AF2641_RS00490	COG0330	HflC and HflK could
AF2641_RS00495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AF2641_RS00510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AF2641_RS00515	COG0517	IMP dehydrogenase activity
AF2641_RS00525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS00535	COG0564	pseudouridine synthase activity
AF2641_RS00540	COG1253	flavin adenine dinucleotide binding
AF2641_RS00545	COG2738	Putative neutral zinc metallopeptidase
AF2641_RS00550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF2641_RS00550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF2641_RS00560	COG0730	response to heat
AF2641_RS00565	COG0425	Belongs to the sulfur carrier protein TusA family
AF2641_RS00570	COG2210	Belongs to the sulfur carrier protein TusA family
AF2641_RS00575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF2641_RS00575	COG0425	Belongs to the sulfur carrier protein TusA family
AF2641_RS00580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF2641_RS00590	COG2766	serine protein kinase
AF2641_RS00595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AF2641_RS00610	COG3382	B3 4 domain protein
AF2641_RS00625	COG0395	ABC-type sugar transport system, permease component
AF2641_RS00630	COG1175	transmembrane transport
AF2641_RS00635	COG1653	transport
AF2641_RS00640	COG2723	6-phospho-beta-galactosidase activity
AF2641_RS00750	COG0735	belongs to the Fur family
AF2641_RS00755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AF2641_RS00770	COG4555	ABC transporter
AF2641_RS00775	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AF2641_RS00780	COG0067	glutamate synthase
AF2641_RS00780	COG0070	glutamate synthase
AF2641_RS00780	COG0069	glutamate synthase activity
AF2641_RS00785	COG4129	membrane
AF2641_RS00790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AF2641_RS00795	COG0601	transmembrane transport
AF2641_RS00800	COG0747	negative chemotaxis
AF2641_RS00805	COG4608	Belongs to the ABC transporter superfamily
AF2641_RS00810	COG0444	Belongs to the ABC transporter superfamily
AF2641_RS00815	COG3557	Belongs to the UPF0374 family
AF2641_RS00835	COG1988	membrane-bound metal-dependent
AF2641_RS00855	COG1620	l-lactate permease
AF2641_RS00860	COG4221	oxidoreductase activity
AF2641_RS00865	COG2137	regulation of response to DNA damage stimulus
AF2641_RS00870	COG1090	epimerase
AF2641_RS00895	COG0840	transmembrane signaling receptor activity
AF2641_RS00915	COG1509	lysine 2,3-aminomutase activity
AF2641_RS00925	COG0189	ligase activity
AF2641_RS00930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AF2641_RS00940	COG1051	belongs to the nudix hydrolase family
AF2641_RS00950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AF2641_RS00970	COG0535	radical SAM domain protein
AF2641_RS00980	COG0387	Pfam Sodium calcium exchanger
AF2641_RS00985	COG0477	Major facilitator Superfamily
AF2641_RS00995	COG1295	ribonuclease BN
AF2641_RS01005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AF2641_RS01010	COG4840	Belongs to the UPF0435 family
AF2641_RS01020	COG0175	sulfate reduction
AF2641_RS01025	COG0306	phosphate transporter
AF2641_RS01030	COG2046	Belongs to the sulfate adenylyltransferase family
AF2641_RS01035	COG0529	Catalyzes the synthesis of activated sulfate
AF2641_RS01050	COG1648	precorrin-2 dehydrogenase activity
AF2641_RS01060	COG1254	Belongs to the acylphosphatase family
AF2641_RS01080	COG0010	Belongs to the arginase family
AF2641_RS01085	COG0446	pyridine nucleotide-disulphide oxidoreductase
AF2641_RS01090	COG0861	Integral membrane protein TerC family
AF2641_RS01095	COG0791	NLP P60 protein
AF2641_RS01095	COG1388	LysM domain
AF2641_RS01100	COG5001	Diguanylate cyclase
AF2641_RS01100	COG3300	MHYT domain
AF2641_RS01105	COG0840	transmembrane signaling receptor activity
AF2641_RS01110	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AF2641_RS01150	COG5002	protein histidine kinase activity
AF2641_RS01195	COG2211	Major facilitator Superfamily
AF2641_RS01205	COG1597	lipid kinase activity
AF2641_RS01225	COG5002	protein histidine kinase activity
AF2641_RS01235	COG1842	Phage shock protein A
AF2641_RS01245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AF2641_RS01250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AF2641_RS01265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AF2641_RS01270	COG1012	belongs to the aldehyde dehydrogenase family
AF2641_RS01330	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AF2641_RS01350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AF2641_RS01355	COG0154	amidase activity
AF2641_RS01360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AF2641_RS01365	COG1115	amino acid carrier protein
AF2641_RS01370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AF2641_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
AF2641_RS01410	COG4851	CamS sex pheromone cAM373 precursor
AF2641_RS01415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AF2641_RS01425	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AF2641_RS01430	COG4496	protein, YerC YecD
AF2641_RS01435	COG1470	cell adhesion involved in biofilm formation
AF2641_RS01440	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AF2641_RS01450	COG0151	Belongs to the GarS family
AF2641_RS01455	COG0138	bifunctional purine biosynthesis protein purh
AF2641_RS01460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AF2641_RS01465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AF2641_RS01470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AF2641_RS01480	COG0047	phosphoribosylformylglycinamidine synthase activity
AF2641_RS01485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AF2641_RS01490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AF2641_RS01495	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AF2641_RS01500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AF2641_RS01505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AF2641_RS01510	COG0071	Belongs to the small heat shock protein (HSP20) family
AF2641_RS01530	COG2252	PERMEase
AF2641_RS01535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AF2641_RS01535	COG0519	Catalyzes the synthesis of GMP from XMP
AF2641_RS01545	COG0165	Argininosuccinate lyase
AF2641_RS01545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AF2641_RS01550	COG2814	Major facilitator Superfamily
AF2641_RS01570	COG0010	Belongs to the arginase family
AF2641_RS01575	COG0151	Belongs to the GarS family
AF2641_RS01580	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AF2641_RS01585	COG0367	asparagine synthase
AF2641_RS01600	COG0459	protein refolding
AF2641_RS01605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AF2641_RS01610	COG1266	CAAX protease self-immunity
AF2641_RS01620	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AF2641_RS01625	COG0488	(ABC) transporter
AF2641_RS01635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AF2641_RS01640	COG0456	acetyltransferase
AF2641_RS01645	COG1214	PFAM Peptidase M22, glycoprotease
AF2641_RS01650	COG0802	atpase or kinase
AF2641_RS01695	COG0544	peptidyl-prolyl cis-trans isomerase activity
AF2641_RS01735	COG3091	SprT-like family
AF2641_RS01745	COG2183	response to ionizing radiation
AF2641_RS01750	COG2337	Toxic component of a toxin-antitoxin (TA) module
AF2641_RS01755	COG0864	Transcriptional regulator
AF2641_RS01760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AF2641_RS01765	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AF2641_RS01770	COG0736	holo-[acyl-carrier-protein] synthase activity
AF2641_RS01775	COG0513	Belongs to the DEAD box helicase family
AF2641_RS01780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AF2641_RS01785	COG1181	Belongs to the D-alanine--D-alanine ligase family
AF2641_RS01805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AF2641_RS01820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AF2641_RS01825	COG1024	Enoyl-CoA hydratase
AF2641_RS01830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AF2641_RS01835	COG0511	ligase activity, forming carbon-carbon bonds
AF2641_RS01840	COG0439	Biotin carboxylase
AF2641_RS01845	COG0318	PFAM AMP-dependent synthetase and ligase
AF2641_RS01850	COG1960	acyl-CoA dehydrogenase activity
AF2641_RS01860	COG1966	Carbon starvation protein
AF2641_RS01870	COG0492	ferredoxin-NADP+ reductase activity
AF2641_RS01875	COG0789	Transcriptional regulator
AF2641_RS01880	COG2197	response regulator
AF2641_RS01910	COG2336	PFAM SpoVT AbrB
AF2641_RS01945	COG0204	Acyl-transferase
AF2641_RS01955	COG2814	Major facilitator Superfamily
AF2641_RS01960	COG0367	asparagine synthase
AF2641_RS01970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AF2641_RS02050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AF2641_RS02055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AF2641_RS02060	COG4856	YbbR-like protein
AF2641_RS02065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AF2641_RS02070	COG5662	AntiSigma factor
AF2641_RS02075	COG1595	DNA-templated transcription, initiation
AF2641_RS02150	COG0726	polysaccharide deacetylase
AF2641_RS02155	COG2194	sulfuric ester hydrolase activity
AF2641_RS02165	COG0489	protein tyrosine kinase activity
AF2641_RS02170	COG0860	N-Acetylmuramoyl-L-alanine amidase
AF2641_RS02180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AF2641_RS02185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AF2641_RS02190	COG0101	tRNA pseudouridine synthase activity
AF2641_RS02195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AF2641_RS02200	COG1122	ATPase activity
AF2641_RS02205	COG1122	ATPase activity
AF2641_RS02210	COG0203	ribosomal protein L17
AF2641_RS02215	COG0202	RNA polymerase activity
AF2641_RS02220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AF2641_RS02225	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AF2641_RS02230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AF2641_RS02235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AF2641_RS02240	COG0024	Methionine aminopeptidase
AF2641_RS02245	COG0563	adenylate kinase activity
AF2641_RS02250	COG0201	protein transport
AF2641_RS02255	COG0200	Binds to the 23S rRNA
AF2641_RS02260	COG1841	ribosomal large subunit assembly
AF2641_RS02265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AF2641_RS02270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AF2641_RS02275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AF2641_RS02280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AF2641_RS02285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AF2641_RS02290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AF2641_RS02295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AF2641_RS02300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AF2641_RS02305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AF2641_RS02315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AF2641_RS02320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AF2641_RS02325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AF2641_RS02330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AF2641_RS02335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AF2641_RS02340	COG0089	rRNA binding
AF2641_RS02345	COG0088	Forms part of the polypeptide exit tunnel
AF2641_RS02350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AF2641_RS02365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AF2641_RS02370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AF2641_RS02375	COG0049	tRNA binding
AF2641_RS02380	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AF2641_RS02385	COG1358	cellular component organization or biogenesis
AF2641_RS02390	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AF2641_RS02395	COG0085	RNA polymerase activity
AF2641_RS02400	COG2813	Specifically methylates the guanine in position
AF2641_RS02405	COG0222	ribosome binding
AF2641_RS02410	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AF2641_RS02415	COG0081	regulation of translation
AF2641_RS02425	COG0250	Participates in transcription elongation, termination and antitermination
AF2641_RS02430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AF2641_RS02435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AF2641_RS02445	COG3688	RNA-binding protein containing a PIN domain
AF2641_RS02450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AF2641_RS02455	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AF2641_RS02460	COG0215	cysteine-tRNA ligase activity
AF2641_RS02465	COG1045	serine acetyltransferase
AF2641_RS02470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AF2641_RS02475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AF2641_RS02480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AF2641_RS02485	COG4956	integral membrane protein (PIN domain superfamily)
AF2641_RS02490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AF2641_RS02495	COG0542	response to heat
AF2641_RS02500	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AF2641_RS02505	COG3880	PFAM UvrB UvrC protein
AF2641_RS02555	COG0544	peptidyl-prolyl cis-trans isomerase activity
AF2641_RS02585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AF2641_RS02590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AF2641_RS02595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AF2641_RS02600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AF2641_RS02605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AF2641_RS02610	COG0512	Glutamine amidotransferase of anthranilate synthase
AF2641_RS02615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AF2641_RS02620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AF2641_RS02625	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AF2641_RS02630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AF2641_RS02635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AF2641_RS02640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AF2641_RS02645	COG0037	tRNA processing
AF2641_RS02650	COG0515	serine threonine protein kinase
AF2641_RS02655	COG2304	oxidoreductase activity
AF2641_RS02660	COG2208	phosphoserine phosphatase activity
AF2641_RS02675	COG1098	S1 RNA binding domain
AF2641_RS02695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AF2641_RS02700	COG3956	TIGRFAM MazG family protein
AF2641_RS02705	COG2244	polysaccharide biosynthetic process
AF2641_RS02710	COG2002	toxin-antitoxin pair type II binding
AF2641_RS02715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AF2641_RS02725	COG0193	aminoacyl-tRNA hydrolase activity
AF2641_RS02730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AF2641_RS02740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AF2641_RS02745	COG2088	sporulation resulting in formation of a cellular spore
AF2641_RS02750	COG0251	oxidation-reduction process
AF2641_RS02755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AF2641_RS02760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AF2641_RS02765	COG4466	Protein conserved in bacteria
AF2641_RS02775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AF2641_RS02785	COG3584	3D domain protein
AF2641_RS02785	COG3583	domain protein
AF2641_RS02795	COG3584	3D domain protein
AF2641_RS02795	COG3583	domain protein
AF2641_RS02800	COG0084	hydrolase, TatD family'
AF2641_RS02810	COG2002	toxin-antitoxin pair type II binding
AF2641_RS02815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AF2641_RS02820	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AF2641_RS02825	COG4467	Involved in initiation control of chromosome replication
AF2641_RS02830	COG1774	PSP1 C-terminal conserved region
AF2641_RS02835	COG0470	DNA polymerase III
AF2641_RS02840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AF2641_RS02845	COG1982	Orn Lys Arg decarboxylase major
AF2641_RS02890	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AF2641_RS02895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AF2641_RS02900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AF2641_RS02910	COG0590	tRNA wobble adenosine to inosine editing
AF2641_RS02915	COG1428	Deoxynucleoside kinase
AF2641_RS02920	COG1428	Deoxynucleoside kinase
AF2641_RS02930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AF2641_RS02935	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AF2641_RS02940	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AF2641_RS02950	COG0517	IMP dehydrogenase activity
AF2641_RS02950	COG0516	GMP reductase activity
AF2641_RS02990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AF2641_RS02995	COG0187	DNA topoisomerase II activity
AF2641_RS03000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AF2641_RS03005	COG2501	S4 domain
AF2641_RS03010	COG0592	DNA-directed DNA polymerase activity
AF2641_RS03015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AF2641_RS03020	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AF2641_RS03025	COG0594	ribonuclease P activity
AF2641_RS03030	COG0706	membrane insertase activity
AF2641_RS03035	COG1847	R3H domain protein
AF2641_RS03040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AF2641_RS03045	COG0445	tRNA wobble uridine modification
AF2641_RS03050	COG0357	Ribosomal RNA small subunit methyltransferase G
AF2641_RS03055	COG1475	DNA binding
AF2641_RS03060	COG1192	Involved in chromosome partitioning
AF2641_RS03065	COG1475	DNA binding
AF2641_RS03070	COG1811	Na channel or pump
AF2641_RS03080	COG0668	transmembrane transport
AF2641_RS03085	COG4481	Protein conserved in bacteria
AF2641_RS03090	COG0012	GTP binding
AF2641_RS03095	COG0360	Binds together with S18 to 16S ribosomal RNA
AF2641_RS03100	COG0629	single-stranded DNA binding
AF2641_RS03105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AF2641_RS03110	COG4241	membrane
AF2641_RS03115	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AF2641_RS03120	COG0359	binds to the 23S rRNA
AF2641_RS03125	COG0305	Participates in initiation and elongation during chromosome replication
AF2641_RS03130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AF2641_RS03145	COG0745	RESPONSE REGULATOR receiver
AF2641_RS03150	COG5002	protein histidine kinase activity
AF2641_RS03160	COG4853	Protein conserved in bacteria
AF2641_RS03165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AF2641_RS03170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AF2641_RS03185	COG3104	oligopeptide transport
AF2641_RS03190	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AF2641_RS03195	COG1177	transmembrane transport
AF2641_RS03200	COG1176	ABC-type spermidine putrescine transport system, permease component I
AF2641_RS03205	COG3842	ATPase activity
AF2641_RS03215	COG0531	amino acid
AF2641_RS03220	COG0697	spore germination
AF2641_RS03225	COG0723	plastoquinol--plastocyanin reductase activity
AF2641_RS03225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AF2641_RS03240	COG1454	alcohol dehydrogenase
AF2641_RS03240	COG1012	belongs to the aldehyde dehydrogenase family
AF2641_RS03250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AF2641_RS03255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AF2641_RS03260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AF2641_RS03265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AF2641_RS03280	COG0765	amino acid transport
AF2641_RS03290	COG0686	Belongs to the AlaDH PNT family
AF2641_RS03295	COG2508	Transcriptional regulator
AF2641_RS03295	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AF2641_RS03300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AF2641_RS03305	COG2390	Transcriptional regulator
AF2641_RS03310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AF2641_RS03315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AF2641_RS03325	COG0295	cytidine deaminase activity
AF2641_RS03340	COG0477	Major facilitator Superfamily
AF2641_RS03345	COG1216	Glycosyl transferase, family 2
AF2641_RS03355	COG0450	alkyl hydroperoxide reductase
AF2641_RS03360	COG3634	alkyl hydroperoxide reductase activity
AF2641_RS03365	COG0423	glycine-tRNA ligase activity
AF2641_RS03370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AF2641_RS03380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AF2641_RS03380	COG0475	glutathione-regulated potassium exporter activity
AF2641_RS03385	COG0366	Alpha amylase catalytic
AF2641_RS03395	COG2363	Small membrane protein
AF2641_RS03405	COG3773	Cell wall hydrolase
AF2641_RS03410	COG3253	May function as heme-dependent peroxidase
AF2641_RS03415	COG1238	metal cluster binding
AF2641_RS03420	COG0280	phosphate acetyltransferase
AF2641_RS03425	COG0095	Lipoate-protein ligase
AF2641_RS03435	COG4844	belongs to the
AF2641_RS03440	COG1078	dGTPase activity
AF2641_RS03445	COG3465	dGTPase activity
AF2641_RS03455	COG1994	Peptidase M50
AF2641_RS03465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AF2641_RS03470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AF2641_RS03475	COG0010	Belongs to the arginase family
AF2641_RS03490	COG0018	arginyl-trna synthetase
AF2641_RS03495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AF2641_RS03500	COG2181	nitrate reductase activity
AF2641_RS03500	COG0247	lactate metabolic process
AF2641_RS03505	COG0183	Belongs to the thiolase family
AF2641_RS03510	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF2641_RS03515	COG1960	acyl-CoA dehydrogenase activity
AF2641_RS03520	COG1960	acyl-CoA dehydrogenase activity
AF2641_RS03530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF2641_RS03530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF2641_RS03530	COG1703	isobutyryl-CoA mutase activity
AF2641_RS03535	COG3343	RNA polymerase activity
AF2641_RS03540	COG0504	CTP synthase activity
AF2641_RS03545	COG4821	SIS domain
AF2641_RS03550	COG2204	response regulator
AF2641_RS03560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AF2641_RS03565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AF2641_RS03570	COG1494	fructose-1,6-bisphosphatase
AF2641_RS03575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AF2641_RS03580	COG0254	rRNA binding
AF2641_RS03585	COG1435	thymidine kinase activity
AF2641_RS03590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AF2641_RS03595	COG2890	protein-(glutamine-N5) methyltransferase activity
AF2641_RS03605	COG0009	L-threonylcarbamoyladenylate synthase
AF2641_RS03610	COG1971	Probably functions as a manganese efflux pump
AF2641_RS03620	COG0840	transmembrane signaling receptor activity
AF2641_RS03625	COG0698	ribose 5-phosphate isomerase
AF2641_RS03630	COG4475	Protein of unknown function (DUF436)
AF2641_RS03635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AF2641_RS03640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AF2641_RS03645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AF2641_RS03660	COG0356	it plays a direct role in the translocation of protons across the membrane
AF2641_RS03665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AF2641_RS03670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AF2641_RS03675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AF2641_RS03680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AF2641_RS03685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AF2641_RS03690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AF2641_RS03695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AF2641_RS03700	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AF2641_RS03705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AF2641_RS03710	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AF2641_RS03715	COG0649	NAD binding
AF2641_RS03720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AF2641_RS03725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AF2641_RS03730	COG0839	Belongs to the complex I subunit 6 family
AF2641_RS03735	COG0713	ATP synthesis coupled electron transport
AF2641_RS03740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AF2641_RS03750	COG1007	ATP synthesis coupled electron transport
AF2641_RS03755	COG4836	Membrane
AF2641_RS03765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AF2641_RS03770	COG2385	sporulation resulting in formation of a cellular spore
AF2641_RS03775	COG0739	heme binding
AF2641_RS03780	COG1609	Transcriptional regulator
AF2641_RS03785	COG1077	Cell shape determining protein MreB Mrl
AF2641_RS03795	COG4786	Flagellar basal body rod
AF2641_RS03800	COG4786	Flagellar basal body rod
AF2641_RS03810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AF2641_RS03825	COG3944	biosynthesis protein
AF2641_RS03830	COG0489	protein tyrosine kinase activity
AF2641_RS03835	COG4464	protein tyrosine phosphatase activity
AF2641_RS03845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AF2641_RS03850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AF2641_RS03855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AF2641_RS03860	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AF2641_RS03870	COG1216	Glycosyl transferase, family 2
AF2641_RS03885	COG1216	Glycosyl transferase, family 2
AF2641_RS03890	COG1045	serine acetyltransferase
AF2641_RS03905	COG0438	transferase activity, transferring glycosyl groups
AF2641_RS03925	COG0438	transferase activity, transferring glycosyl groups
AF2641_RS03935	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AF2641_RS03935	COG0662	Cupin 2, conserved barrel domain protein
AF2641_RS03945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AF2641_RS03950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AF2641_RS03950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AF2641_RS03950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AF2641_RS03955	COG1482	cell wall glycoprotein biosynthetic process
AF2641_RS03960	COG1940	carbohydrate kinase activity
AF2641_RS03995	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AF2641_RS04000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AF2641_RS04010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AF2641_RS04020	COG3177	Filamentation induced by cAMP protein fic
AF2641_RS04035	COG0673	inositol 2-dehydrogenase activity
AF2641_RS04040	COG2996	Protein conserved in bacteria
AF2641_RS04045	COG1405	negative regulation of cell septum assembly
AF2641_RS04045	COG3012	SEC-C Motif Domain Protein
AF2641_RS04055	COG3266	domain, Protein
AF2641_RS04055	COG2911	Protein conserved in bacteria
AF2641_RS04055	COG1361	Conserved repeat domain
AF2641_RS04070	COG2244	polysaccharide biosynthetic process
AF2641_RS04085	COG0840	transmembrane signaling receptor activity
AF2641_RS04090	COG4903	ComK protein
AF2641_RS04100	COG0527	aspartate kinase activity
AF2641_RS04110	COG3764	Sortase (surface protein transpeptidase)
AF2641_RS04125	COG1396	sequence-specific DNA binding
AF2641_RS04140	COG0653	protein targeting
AF2641_RS04155	COG0791	NLP P60 protein
AF2641_RS04155	COG1388	LysM domain
AF2641_RS04195	COG0737	Belongs to the 5'-nucleotidase family
AF2641_RS04200	COG1404	Belongs to the peptidase S8 family
AF2641_RS04210	COG1361	Conserved repeat domain
AF2641_RS04215	COG2247	cell wall binding repeat
AF2641_RS04215	COG2385	sporulation resulting in formation of a cellular spore
AF2641_RS04225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AF2641_RS04230	COG1316	TRANSCRIPTIONal
AF2641_RS04235	COG1739	Uncharacterized protein family UPF0029
AF2641_RS04240	COG4585	Histidine kinase
AF2641_RS04245	COG2197	response regulator
AF2641_RS04255	COG1307	EDD domain protein, DegV family
AF2641_RS04265	COG1040	competence protein
AF2641_RS04275	COG2257	FlhB HrpN YscU SpaS Family
AF2641_RS04290	COG1728	Protein conserved in bacteria
AF2641_RS04310	COG1256	bacterial-type flagellum assembly
AF2641_RS04310	COG4786	Flagellar basal body rod
AF2641_RS04315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AF2641_RS04325	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AF2641_RS04330	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AF2641_RS04345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AF2641_RS04350	COG1334	flagellar protein FlaG
AF2641_RS04355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AF2641_RS04360	COG1516	flagellar protein fliS
AF2641_RS04390	COG0653	protein targeting
AF2641_RS04400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AF2641_RS04410	COG2884	Cell division ATP-binding protein ftsE
AF2641_RS04415	COG2177	Part of the ABC transporter FtsEX involved in
AF2641_RS04420	COG0739	heme binding
AF2641_RS04425	COG3409	Peptidoglycan-binding domain 1 protein
AF2641_RS04425	COG0793	Belongs to the peptidase S41A family
AF2641_RS04430	COG0789	Transcriptional regulator
AF2641_RS04435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AF2641_RS04440	COG4897	Protein conserved in bacteria
AF2641_RS04445	COG0556	nucleotide-excision repair
AF2641_RS04450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AF2641_RS04465	COG1950	PFAM Membrane protein of
AF2641_RS04475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AF2641_RS04480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AF2641_RS04485	COG0546	phosphoglycolate phosphatase activity
AF2641_RS04490	COG0110	maltose O-acetyltransferase activity
AF2641_RS04495	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AF2641_RS04500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AF2641_RS04510	COG0131	Imidazoleglycerol-phosphate dehydratase
AF2641_RS04515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AF2641_RS04520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AF2641_RS04525	COG0107	imidazoleglycerol-phosphate synthase activity
AF2641_RS04530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AF2641_RS04530	COG0140	phosphoribosyl-ATP diphosphatase activity
AF2641_RS04535	COG0457	Tetratricopeptide repeat
AF2641_RS04540	COG0492	ferredoxin-NADP+ reductase activity
AF2641_RS04545	COG1051	belongs to the nudix hydrolase family
AF2641_RS04550	COG1660	Displays ATPase and GTPase activities
AF2641_RS04555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AF2641_RS04560	COG1481	regulation of sporulation
AF2641_RS04565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AF2641_RS04570	COG0740	serine-type endopeptidase activity
AF2641_RS04580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AF2641_RS04600	COG0126	phosphoglycerate kinase activity
AF2641_RS04605	COG0149	triose-phosphate isomerase activity
AF2641_RS04610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AF2641_RS04615	COG0148	phosphopyruvate hydratase activity
AF2641_RS04635	COG3209	COG3209 Rhs family protein
AF2641_RS04700	COG3209	COG3209 Rhs family protein
AF2641_RS04730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AF2641_RS04740	COG0557	exoribonuclease II activity
AF2641_RS04745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AF2641_RS04765	COG5577	PFAM Coat F domain
AF2641_RS04775	COG0506	proline dehydrogenase activity
AF2641_RS04785	COG1024	Enoyl-CoA hydratase
AF2641_RS04785	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF2641_RS04790	COG0183	Belongs to the thiolase family
AF2641_RS04795	COG1960	acyl-CoA dehydrogenase activity
AF2641_RS04800	COG1393	Belongs to the ArsC family
AF2641_RS04805	COG0509	glycine decarboxylation via glycine cleavage system
AF2641_RS04815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AF2641_RS04820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS04830	COG2873	o-acetylhomoserine
AF2641_RS04845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AF2641_RS04850	COG2011	ABC-type metal ion transport system permease component
AF2641_RS04855	COG1464	Belongs to the NlpA lipoprotein family
AF2641_RS04860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AF2641_RS04865	COG0396	ATPase activity
AF2641_RS04870	COG0719	Fe-S assembly protein
AF2641_RS04875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AF2641_RS04880	COG0822	iron-sulfur transferase activity
AF2641_RS04885	COG0719	Fe-S assembly protein
AF2641_RS04945	COG3344	reverse transcriptase
AF2641_RS04965	COG3328	transposase activity
AF2641_RS04970	COG0180	Tryptophanyl-tRNA synthetase
AF2641_RS05035	COG1131	(ABC) transporter
AF2641_RS05045	COG1801	Protein of unknown function DUF72
AF2641_RS05050	COG0730	response to heat
AF2641_RS05055	COG0737	Belongs to the 5'-nucleotidase family
AF2641_RS05060	COG3377	Domain of unknown function (DUF1805)
AF2641_RS05070	COG0733	neurotransmitter:sodium symporter activity
AF2641_RS05080	COG0739	heme binding
AF2641_RS05085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AF2641_RS05095	COG4470	Protein conserved in bacteria
AF2641_RS05110	COG2445	Protein of unknown function DUF86
AF2641_RS05120	COG0647	UMP catabolic process
AF2641_RS05125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AF2641_RS05130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AF2641_RS05135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AF2641_RS05140	COG0460	homoserine dehydrogenase
AF2641_RS05145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AF2641_RS05150	COG0083	homoserine kinase activity
AF2641_RS05155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AF2641_RS05160	COG4837	Protein of unknown function (DUF1462)
AF2641_RS05165	COG1252	NADH dehydrogenase
AF2641_RS05170	COG4844	belongs to the
AF2641_RS05180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AF2641_RS05185	COG0316	Belongs to the HesB IscA family
AF2641_RS05190	COG5416	Lipopolysaccharide assembly protein A domain
AF2641_RS05195	COG0492	ferredoxin-NADP+ reductase activity
AF2641_RS05200	COG1252	NADH dehydrogenase
AF2641_RS05210	COG3584	3D domain protein
AF2641_RS05215	COG1268	BioY protein
AF2641_RS05240	COG2032	superoxide dismutase activity
AF2641_RS05245	COG1522	sequence-specific DNA binding
AF2641_RS05250	COG0436	Aminotransferase
AF2641_RS05260	COG1098	S1 RNA binding domain
AF2641_RS05265	COG2155	Conserved Protein
AF2641_RS05270	COG1979	alcohol dehydrogenase
AF2641_RS05285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AF2641_RS05345	COG2274	protein secretion by the type I secretion system
AF2641_RS05400	COG1131	(ABC) transporter
AF2641_RS05430	COG0789	Transcriptional regulator
AF2641_RS05435	COG1253	flavin adenine dinucleotide binding
AF2641_RS05440	COG0640	Transcriptional regulator
AF2641_RS05450	COG1285	pathogenesis
AF2641_RS05505	COG0544	peptidyl-prolyl cis-trans isomerase activity
AF2641_RS05595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AF2641_RS05600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AF2641_RS05605	COG0297	glycogen (starch) synthase activity
AF2641_RS05610	COG0058	SHG alpha-glucan phosphorylase activity
AF2641_RS05615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AF2641_RS05620	COG1575	Belongs to the MenA family. Type 1 subfamily
AF2641_RS05625	COG1169	isochorismate synthase
AF2641_RS05630	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AF2641_RS05635	COG0596	Alpha beta hydrolase
AF2641_RS05640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AF2641_RS05645	COG0318	PFAM AMP-dependent synthetase and ligase
AF2641_RS05650	COG1294	oxidase, subunit
AF2641_RS05655	COG1271	oxidase subunit
AF2641_RS05675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AF2641_RS05680	COG0716	FMN binding
AF2641_RS05690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AF2641_RS05695	COG1294	oxidase, subunit
AF2641_RS05700	COG1271	oxidase subunit
AF2641_RS05705	COG3443	Belongs to the bacterial solute-binding protein 9 family
AF2641_RS05705	COG0803	Belongs to the bacterial solute-binding protein 9 family
AF2641_RS05710	COG0523	cobalamin synthesis protein
AF2641_RS05715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AF2641_RS05720	COG1854	S-ribosylhomocysteine lyase activity
AF2641_RS05730	COG0783	Belongs to the Dps family
AF2641_RS05740	COG0494	nUDIX hydrolase
AF2641_RS05745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AF2641_RS05750	COG1116	anion transmembrane transporter activity
AF2641_RS05755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AF2641_RS05770	COG1122	ATPase activity
AF2641_RS05795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AF2641_RS05800	COG0671	phosphoesterase, PA-phosphatase related
AF2641_RS05805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AF2641_RS05810	COG2267	carboxylic ester hydrolase activity
AF2641_RS05825	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AF2641_RS05830	COG1242	4 iron, 4 sulfur cluster binding
AF2641_RS05845	COG0495	leucyl-tRNA aminoacylation
AF2641_RS05850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF2641_RS05855	COG2081	HI0933 family
AF2641_RS05860	COG2244	polysaccharide biosynthetic process
AF2641_RS05870	COG1187	pseudouridine synthase activity
AF2641_RS05875	COG1349	DNA-binding transcription factor activity
AF2641_RS05880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AF2641_RS05895	COG1380	Effector of murein hydrolase LrgA
AF2641_RS05900	COG1346	cytolysis
AF2641_RS05910	COG1523	belongs to the glycosyl hydrolase 13 family
AF2641_RS05915	COG0510	thiamine kinase activity
AF2641_RS05925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AF2641_RS05930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF2641_RS05940	COG1363	Peptidase, m42
AF2641_RS05945	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AF2641_RS05950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS05955	COG4848	Belongs to the UPF0354 family
AF2641_RS05960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AF2641_RS05965	COG1674	ftsk spoiiie
AF2641_RS05965	COG1674	ftsk spoiiie
AF2641_RS05975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AF2641_RS05980	COG3118	belongs to the thioredoxin family
AF2641_RS05990	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AF2641_RS05995	COG2309	aminopeptidase activity
AF2641_RS06005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AF2641_RS06005	COG1605	Chorismate mutase
AF2641_RS06020	COG0123	including yeast histone deacetylase and acetoin utilization protein
AF2641_RS06025	COG0517	IMP dehydrogenase activity
AF2641_RS06030	COG0454	-acetyltransferase
AF2641_RS06035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF2641_RS06050	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AF2641_RS06055	COG2203	Gaf domain
AF2641_RS06055	COG2199	diguanylate cyclase activity
AF2641_RS06060	COG1956	GAF domain-containing protein
AF2641_RS06065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AF2641_RS06070	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AF2641_RS06075	COG1114	Component of the transport system for branched-chain amino acids
AF2641_RS06080	COG1104	cysteine desulfurase activity
AF2641_RS06085	COG0301	tRNA thio-modification
AF2641_RS06095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF2641_RS06120	COG0683	leucine binding
AF2641_RS06135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AF2641_RS06145	COG3874	Sporulation protein YtfJ
AF2641_RS06150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AF2641_RS06155	COG0827	DNA restriction-modification system
AF2641_RS06160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AF2641_RS06170	COG0137	argininosuccinate synthase activity
AF2641_RS06175	COG0165	Argininosuccinate lyase
AF2641_RS06190	COG0006	proline dipeptidase activity
AF2641_RS06195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AF2641_RS06200	COG4109	DRTGG domain
AF2641_RS06210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AF2641_RS06225	COG0587	DNA-directed DNA polymerase activity
AF2641_RS06230	COG0281	malic enzyme
AF2641_RS06240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AF2641_RS06245	COG0825	malonyl-CoA metabolic process
AF2641_RS06250	COG0205	6-phosphofructokinase activity
AF2641_RS06260	COG3030	protein affecting phage T7 exclusion by the F plasmid
AF2641_RS06265	COG0628	permease
AF2641_RS06270	COG2707	UPF0756 membrane protein
AF2641_RS06275	COG0372	Belongs to the citrate synthase family
AF2641_RS06280	COG0538	isocitrate dehydrogenase activity
AF2641_RS06285	COG0039	L-malate dehydrogenase activity
AF2641_RS06295	COG0745	RESPONSE REGULATOR receiver
AF2641_RS06300	COG5002	protein histidine kinase activity
AF2641_RS06310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AF2641_RS06315	COG1971	Probably functions as a manganese efflux pump
AF2641_RS06325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AF2641_RS06330	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AF2641_RS06340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AF2641_RS06345	COG3611	Membrane attachment protein
AF2641_RS06350	COG1484	DNA-dependent DNA replication
AF2641_RS06360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AF2641_RS06370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AF2641_RS06375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AF2641_RS06385	COG1363	Peptidase, m42
AF2641_RS06410	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AF2641_RS06415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AF2641_RS06420	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AF2641_RS06430	COG1609	Transcriptional regulator
AF2641_RS06445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AF2641_RS06450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AF2641_RS06455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AF2641_RS06460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AF2641_RS06460	COG0072	phenylalanine-tRNA ligase activity
AF2641_RS06525	COG4585	Histidine kinase
AF2641_RS06530	COG2197	response regulator
AF2641_RS06565	COG1132	(ABC) transporter
AF2641_RS06600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AF2641_RS06615	COG2409	Drug exporters of the RND superfamily
AF2641_RS06615	COG1033	growth of symbiont in host cell
AF2641_RS06630	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AF2641_RS06635	COG1286	toxin biosynthetic process
AF2641_RS06640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AF2641_RS06640	COG1796	DNA polymerase
AF2641_RS06645	COG1193	negative regulation of DNA recombination
AF2641_RS06650	COG3766	membrane
AF2641_RS06660	COG0318	PFAM AMP-dependent synthetase and ligase
AF2641_RS06665	COG1309	transcriptional regulator
AF2641_RS06670	COG1024	Enoyl-CoA hydratase
AF2641_RS06675	COG2086	electron transfer activity
AF2641_RS06680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AF2641_RS06685	COG3118	belongs to the thioredoxin family
AF2641_RS06695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AF2641_RS06730	COG0322	excinuclease ABC activity
AF2641_RS06735	COG1719	4-vinyl reductase, 4VR
AF2641_RS06740	COG2009	succinate dehydrogenase
AF2641_RS06745	COG1053	succinate dehydrogenase
AF2641_RS06750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AF2641_RS06755	COG0824	Thioesterase
AF2641_RS06760	COG2197	response regulator
AF2641_RS06765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AF2641_RS06770	COG5401	PFAM Sporulation and spore germination
AF2641_RS06775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AF2641_RS06780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AF2641_RS06785	COG0622	Phosphoesterase
AF2641_RS06795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AF2641_RS06800	COG0028	Belongs to the TPP enzyme family
AF2641_RS06805	COG0440	acetolactate synthase activity
AF2641_RS06810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AF2641_RS06815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AF2641_RS06820	COG0473	3-isopropylmalate dehydrogenase activity
AF2641_RS06825	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AF2641_RS06830	COG0066	3-isopropylmalate dehydratase activity
AF2641_RS06840	COG0544	peptidyl-prolyl cis-trans isomerase activity
AF2641_RS06845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AF2641_RS06850	COG0470	DNA polymerase III
AF2641_RS06850	COG1067	ATP-dependent peptidase activity
AF2641_RS06860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AF2641_RS06875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AF2641_RS06880	COG0181	hydroxymethylbilane synthase activity
AF2641_RS06885	COG1587	Uroporphyrinogen-III synthase
AF2641_RS06890	COG0113	porphobilinogen synthase activity
AF2641_RS06895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AF2641_RS06900	COG1388	LysM domain
AF2641_RS06900	COG1388	LysM domain
AF2641_RS06905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AF2641_RS06915	COG0525	valine-tRNA ligase activity
AF2641_RS06920	COG0285	dihydrofolate synthase activity
AF2641_RS06965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AF2641_RS06975	COG1459	type II secretion system
AF2641_RS06980	COG4969	Belongs to the N-Me-Phe pilin family
AF2641_RS06985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AF2641_RS07020	COG2003	Belongs to the UPF0758 family
AF2641_RS07025	COG1077	Cell shape determining protein MreB Mrl
AF2641_RS07030	COG1792	Involved in formation and maintenance of cell shape
AF2641_RS07040	COG0850	regulation of cytokinetic process
AF2641_RS07045	COG2894	cell division
AF2641_RS07050	COG0739	heme binding
AF2641_RS07055	COG1994	Peptidase M50
AF2641_RS07060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AF2641_RS07065	COG2868	ribosomal protein
AF2641_RS07070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AF2641_RS07075	COG3290	protein histidine kinase activity
AF2641_RS07080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AF2641_RS07085	COG4492	Belongs to the UPF0735 family
AF2641_RS07090	COG0077	Prephenate dehydratase
AF2641_RS07095	COG1827	regulation of RNA biosynthetic process
AF2641_RS07100	COG1104	cysteine desulfurase activity
AF2641_RS07105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AF2641_RS07110	COG0157	Belongs to the NadC ModD family
AF2641_RS07115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AF2641_RS07120	COG1388	LysM domain
AF2641_RS07125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AF2641_RS07135	COG0217	transcriptional regulatory protein
AF2641_RS07145	COG0632	four-way junction helicase activity
AF2641_RS07150	COG2255	four-way junction helicase activity
AF2641_RS07165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AF2641_RS07170	COG0343	queuine tRNA-ribosyltransferase activity
AF2641_RS07175	COG1862	Preprotein translocase
AF2641_RS07185	COG2323	membrane
AF2641_RS07190	COG2244	polysaccharide biosynthetic process
AF2641_RS07200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AF2641_RS07200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AF2641_RS07205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AF2641_RS07210	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AF2641_RS07210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AF2641_RS07215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AF2641_RS07220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AF2641_RS07225	COG1490	D-aminoacyl-tRNA deacylase activity
AF2641_RS07230	COG0860	N-Acetylmuramoyl-L-alanine amidase
AF2641_RS07235	COG0124	histidyl-tRNA synthetase
AF2641_RS07240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AF2641_RS07250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AF2641_RS07255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AF2641_RS07260	COG1309	transcriptional regulator
AF2641_RS07265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AF2641_RS07270	COG1959	2 iron, 2 sulfur cluster binding
AF2641_RS07275	COG1104	cysteine desulfurase activity
AF2641_RS07280	COG0482	sulfurtransferase activity
AF2641_RS07290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AF2641_RS07310	COG0628	permease
AF2641_RS07315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AF2641_RS07320	COG4472	Bacterial protein of unknown function (DUF965)
AF2641_RS07325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AF2641_RS07330	COG3906	Belongs to the UPF0473 family
AF2641_RS07335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AF2641_RS07345	COG0826	peptidase U32
AF2641_RS07350	COG0826	peptidase U32
AF2641_RS07355	COG0572	uridine kinase
AF2641_RS07360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AF2641_RS07365	COG0768	penicillin binding
AF2641_RS07380	COG2226	methyltransferase
AF2641_RS07385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AF2641_RS07390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AF2641_RS07395	COG0626	cystathionine gamma-synthase activity
AF2641_RS07445	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AF2641_RS07460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AF2641_RS07465	COG1360	Flagellar Motor Protein
AF2641_RS07470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AF2641_RS07475	COG1183	phosphatidylcholine synthase activity
AF2641_RS07480	COG0688	phosphatidylethanolamine metabolic process
AF2641_RS07490	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AF2641_RS07495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AF2641_RS07500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AF2641_RS07505	COG1534	Rna-binding protein
AF2641_RS07510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AF2641_RS07515	COG1713	HD superfamily hydrolase involved in NAD metabolism
AF2641_RS07520	COG0799	negative regulation of ribosome biogenesis
AF2641_RS07525	COG2226	methyltransferase
AF2641_RS07530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AF2641_RS07535	COG1596	polysaccharide export
AF2641_RS07535	COG1555	photosystem II stabilization
AF2641_RS07540	COG2131	deaminase
AF2641_RS07545	COG2333	competence protein COMEC
AF2641_RS07545	COG0658	competence protein
AF2641_RS07555	COG1466	dna polymerase III delta subunit
AF2641_RS07560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AF2641_RS07565	COG0268	Binds directly to 16S ribosomal RNA
AF2641_RS07570	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AF2641_RS07575	COG0860	N-Acetylmuramoyl-L-alanine amidase
AF2641_RS07585	COG0481	GTPase activity
AF2641_RS07590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AF2641_RS07595	COG1420	regulation of RNA biosynthetic process
AF2641_RS07600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AF2641_RS07605	COG0443	Heat shock 70 kDa protein
AF2641_RS07610	COG0484	heat shock protein binding
AF2641_RS07615	COG2264	protein methyltransferase activity
AF2641_RS07620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AF2641_RS07625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AF2641_RS07630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AF2641_RS07635	COG1610	YqeY-like protein
AF2641_RS07640	COG1030	water channel activity
AF2641_RS07645	COG4864	UPF0365 protein
AF2641_RS07665	COG1702	phosphate starvation-inducible protein PhoH
AF2641_RS07670	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AF2641_RS07675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AF2641_RS07680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AF2641_RS07690	COG1381	Involved in DNA repair and RecF pathway recombination
AF2641_RS07695	COG0517	IMP dehydrogenase activity
AF2641_RS07700	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AF2641_RS07710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AF2641_RS07720	COG2010	Cytochrome c
AF2641_RS07725	COG2384	SAM-dependent methyltransferase
AF2641_RS07730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AF2641_RS07735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AF2641_RS07750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AF2641_RS07760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AF2641_RS07765	COG1121	(ABC) transporter
AF2641_RS07770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AF2641_RS07775	COG0735	belongs to the Fur family
AF2641_RS07780	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AF2641_RS07785	COG4709	membrane
AF2641_RS07790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AF2641_RS07795	COG1388	LysM domain
AF2641_RS07800	COG0840	transmembrane signaling receptor activity
AF2641_RS07805	COG5521	maltodextrose utilization protein MalA
AF2641_RS07820	COG0477	Major facilitator Superfamily
AF2641_RS07825	COG0768	penicillin binding
AF2641_RS07830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AF2641_RS07835	COG0573	inorganic phosphate transmembrane transporter activity
AF2641_RS07840	COG0581	inorganic phosphate transmembrane transporter activity
AF2641_RS07845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AF2641_RS07850	COG0704	Plays a role in the regulation of phosphate uptake
AF2641_RS07865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AF2641_RS07870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AF2641_RS07875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AF2641_RS07880	COG0039	L-malate dehydrogenase activity
AF2641_RS07890	COG0457	Tetratricopeptide repeat
AF2641_RS07890	COG0705	Rhomboid family
AF2641_RS07900	COG0697	spore germination
AF2641_RS07905	COG4483	Protein conserved in bacteria
AF2641_RS07910	COG1940	carbohydrate kinase activity
AF2641_RS07915	COG1368	sulfuric ester hydrolase activity
AF2641_RS07930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF2641_RS07950	COG1393	Belongs to the ArsC family
AF2641_RS07955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AF2641_RS07960	COG1459	type II secretion system
AF2641_RS07965	COG4537	Required for transformation and DNA binding
AF2641_RS07970	COG4970	Tfp pilus assembly protein FimT
AF2641_RS08005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AF2641_RS08010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AF2641_RS08015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AF2641_RS08020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AF2641_RS08025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF2641_RS08030	COG0095	Lipoate-protein ligase
AF2641_RS08035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AF2641_RS08040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AF2641_RS08050	COG1321	iron dependent repressor
AF2641_RS08055	COG1752	Esterase of the alpha-beta hydrolase superfamily
AF2641_RS08065	COG3872	metal-dependent enzyme
AF2641_RS08075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AF2641_RS08080	COG0006	proline dipeptidase activity
AF2641_RS08085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AF2641_RS08105	COG3854	ATPases associated with a variety of cellular activities
AF2641_RS08145	COG0511	ligase activity, forming carbon-carbon bonds
AF2641_RS08150	COG0439	Biotin carboxylase
AF2641_RS08155	COG1302	Protein conserved in bacteria
AF2641_RS08160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AF2641_RS08165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AF2641_RS08170	COG1570	exodeoxyribonuclease VII activity
AF2641_RS08175	COG1722	exodeoxyribonuclease VII activity
AF2641_RS08185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AF2641_RS08190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AF2641_RS08200	COG0497	DNA recombination
AF2641_RS08205	COG0750	zinc metalloprotease
AF2641_RS08215	COG3093	addiction module antidote protein HigA
AF2641_RS08220	COG0584	glycerophosphoryl diester phosphodiesterase
AF2641_RS08230	COG3829	transcription factor binding
AF2641_RS08230	COG3290	protein histidine kinase activity
AF2641_RS08235	COG0280	phosphate acetyltransferase
AF2641_RS08245	COG3426	butyrate kinase activity
AF2641_RS08250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AF2641_RS08255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AF2641_RS08260	COG0022	dehydrogenase e1 component
AF2641_RS08265	COG0508	dehydrogenase complex catalyzes the overall conversion of
AF2641_RS08270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF2641_RS08275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF2641_RS08275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AF2641_RS08285	COG4129	membrane
AF2641_RS08290	COG1376	ErfK ybiS ycfS ynhG family protein
AF2641_RS08295	COG0346	lactoylglutathione lyase activity
AF2641_RS08300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AF2641_RS08310	COG2195	Cleaves the N-terminal amino acid of tripeptides
AF2641_RS08320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AF2641_RS08325	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AF2641_RS08330	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AF2641_RS08335	COG1234	tRNA 3'-trailer cleavage
AF2641_RS08365	COG1902	pentaerythritol trinitrate reductase activity
AF2641_RS08370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AF2641_RS08375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF2641_RS08380	COG0300	oxidoreductase activity
AF2641_RS08385	COG4918	Iron-sulphur cluster biosynthesis
AF2641_RS08405	COG0667	Aldo Keto reductase
AF2641_RS08410	COG0494	nUDIX hydrolase
AF2641_RS08415	COG1300	Membrane
AF2641_RS08430	COG0735	belongs to the Fur family
AF2641_RS08440	COG4974	Belongs to the 'phage' integrase family
AF2641_RS08460	COG1686	Belongs to the peptidase S11 family
AF2641_RS08470	COG2172	sigma factor antagonist activity
AF2641_RS08495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AF2641_RS08510	COG0697	spore germination
AF2641_RS08515	COG0019	diaminopimelate decarboxylase activity
AF2641_RS08520	COG4086	secreted protein
AF2641_RS08525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AF2641_RS08530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AF2641_RS08530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AF2641_RS08535	COG0307	riboflavin synthase, alpha
AF2641_RS08540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AF2641_RS08540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AF2641_RS08545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AF2641_RS08555	COG1547	Domain of unknown function (DUF309)
AF2641_RS08560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AF2641_RS08565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AF2641_RS08585	COG1181	Belongs to the D-alanine--D-alanine ligase family
AF2641_RS08590	COG1181	Belongs to the D-alanine--D-alanine ligase family
AF2641_RS08595	COG0640	Transcriptional regulator
AF2641_RS08610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AF2641_RS08615	COG1686	Belongs to the peptidase S11 family
AF2641_RS08620	COG2715	membrane protein required for spore maturation
AF2641_RS08625	COG0700	Nucleoside recognition
AF2641_RS08635	COG1187	pseudouridine synthase activity
AF2641_RS08640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS08645	COG1333	cytochrome c biogenesis protein
AF2641_RS08650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AF2641_RS08655	COG0745	RESPONSE REGULATOR receiver
AF2641_RS08660	COG5002	protein histidine kinase activity
AF2641_RS08665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AF2641_RS08670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AF2641_RS08675	COG1120	ATPase activity
AF2641_RS08680	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AF2641_RS08695	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AF2641_RS08710	COG2096	Adenosyltransferase
AF2641_RS08730	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AF2641_RS08735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AF2641_RS08750	COG4955	Helix-turn-helix domain
AF2641_RS08755	COG0514	ATP-dependent DNA helicase (RecQ)
AF2641_RS08760	COG1266	CAAX protease self-immunity
AF2641_RS08775	COG3546	catalase activity
AF2641_RS08795	COG1408	metallophosphoesterase
AF2641_RS08800	COG0789	Transcriptional regulator
AF2641_RS08805	COG4862	establishment of competence for transformation
AF2641_RS08810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AF2641_RS08815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AF2641_RS08820	COG0492	ferredoxin-NADP+ reductase activity
AF2641_RS08825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AF2641_RS08830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AF2641_RS08835	COG2959	enzyme of heme biosynthesis
AF2641_RS08840	COG3773	Cell wall hydrolase
AF2641_RS08840	COG3409	Peptidoglycan-binding domain 1 protein
AF2641_RS08845	COG2339	peptidase activity
AF2641_RS08850	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AF2641_RS08860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AF2641_RS08870	COG0539	negative regulation of cytoplasmic translation
AF2641_RS08875	COG1304	FMN binding
AF2641_RS08900	COG1160	GTP binding
AF2641_RS08905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AF2641_RS08920	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AF2641_RS08930	COG0302	gtp cyclohydrolase
AF2641_RS08940	COG0142	geranyltranstransferase activity
AF2641_RS08945	COG2226	methyltransferase
AF2641_RS08955	COG0105	UTP biosynthetic process
AF2641_RS08960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AF2641_RS08965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AF2641_RS08970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AF2641_RS08975	COG4401	Chorismate mutase type I
AF2641_RS08985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AF2641_RS08990	COG0134	indole-3-glycerol-phosphate synthase activity
AF2641_RS08995	COG0135	phosphoribosylanthranilate isomerase activity
AF2641_RS09000	COG0133	tryptophan synthase activity
AF2641_RS09005	COG0159	tryptophan synthase activity
AF2641_RS09010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AF2641_RS09015	COG0287	Prephenate dehydrogenase
AF2641_RS09020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AF2641_RS09030	COG5582	Belongs to the UPF0302 family
AF2641_RS09055	COG4347	Protein of unknown function (DUF1405)
AF2641_RS09065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AF2641_RS09070	COG1694	Mazg nucleotide pyrophosphohydrolase
AF2641_RS09075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AF2641_RS09080	COG1803	Methylglyoxal synthase
AF2641_RS09085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AF2641_RS09090	COG0438	transferase activity, transferring glycosyl groups
AF2641_RS09095	COG0617	tRNA 3'-terminal CCA addition
AF2641_RS09105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AF2641_RS09110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AF2641_RS09115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AF2641_RS09120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AF2641_RS09120	COG1199	ATP-dependent helicase activity
AF2641_RS09145	COG0017	Asparaginyl-tRNA synthetase
AF2641_RS09150	COG3935	DnaD domain protein
AF2641_RS09155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AF2641_RS09165	COG4499	WXG100 protein secretion system (Wss), protein YukC
AF2641_RS09165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AF2641_RS09170	COG3331	DNA recombination
AF2641_RS09205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AF2641_RS09210	COG2217	Heavy metal translocating P-type atpase
AF2641_RS09245	COG1929	Belongs to the glycerate kinase type-1 family
AF2641_RS09255	COG1120	ATPase activity
AF2641_RS09260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AF2641_RS09265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AF2641_RS09270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AF2641_RS09275	COG0156	8-amino-7-oxononanoate synthase activity
AF2641_RS09280	COG0596	Alpha beta hydrolase
AF2641_RS09285	COG4106	trans-aconitate 2-methyltransferase activity
AF2641_RS09290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AF2641_RS09295	COG0569	domain protein
AF2641_RS09295	COG0475	glutathione-regulated potassium exporter activity
AF2641_RS09310	COG0745	RESPONSE REGULATOR receiver
AF2641_RS09315	COG5002	protein histidine kinase activity
AF2641_RS09325	COG0300	oxidoreductase activity
AF2641_RS09375	COG1104	cysteine desulfurase activity
AF2641_RS09430	COG2195	Cleaves the N-terminal amino acid of tripeptides
AF2641_RS09450	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AF2641_RS09455	COG1968	undecaprenyl-diphosphatase activity
AF2641_RS09460	COG0656	L-ascorbic acid biosynthetic process
AF2641_RS09480	COG1621	beta-fructofuranosidase activity
AF2641_RS09510	COG5002	protein histidine kinase activity
AF2641_RS09510	COG3850	Histidine kinase
AF2641_RS09515	COG0745	RESPONSE REGULATOR receiver
AF2641_RS09530	COG1937	Protein conserved in bacteria
AF2641_RS09535	COG2217	Heavy metal translocating P-type atpase
AF2641_RS09565	COG2608	mercury ion transmembrane transporter activity
AF2641_RS09570	COG2132	Multicopper oxidase
AF2641_RS09575	COG0367	asparagine synthase
AF2641_RS09590	COG0415	Belongs to the DNA photolyase family
AF2641_RS09595	COG1012	belongs to the aldehyde dehydrogenase family
AF2641_RS09605	COG2246	polysaccharide biosynthetic process
AF2641_RS09610	COG0583	DNA-binding transcription factor activity
AF2641_RS09615	COG0069	glutamate synthase activity
AF2641_RS09615	COG0070	glutamate synthase
AF2641_RS09615	COG0067	glutamate synthase
AF2641_RS09620	COG0493	'glutamate synthase
AF2641_RS09630	COG0129	dihydroxy-acid dehydratase activity
AF2641_RS09640	COG1960	acyl-CoA dehydrogenase activity
AF2641_RS09650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AF2641_RS09660	COG0531	amino acid
AF2641_RS09665	COG0028	Belongs to the TPP enzyme family
AF2641_RS09670	COG1012	belongs to the aldehyde dehydrogenase family
AF2641_RS09685	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AF2641_RS09690	COG0644	oxidoreductase
AF2641_RS09710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AF2641_RS09720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AF2641_RS09725	COG0674	pyruvate-flavodoxin oxidoreductase activity
AF2641_RS09755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AF2641_RS09760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AF2641_RS09765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AF2641_RS09775	COG4152	abc transporter atp-binding protein
AF2641_RS09780	COG1668	transmembrane transport
AF2641_RS09795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AF2641_RS09805	COG0318	PFAM AMP-dependent synthetase and ligase
AF2641_RS09810	COG1960	acyl-CoA dehydrogenase activity
AF2641_RS09815	COG1272	protein, Hemolysin III
AF2641_RS09835	COG3314	Sporulation integral membrane protein YlbJ
AF2641_RS09845	COG0531	amino acid
AF2641_RS09850	COG0803	Belongs to the bacterial solute-binding protein 9 family
AF2641_RS09855	COG1121	(ABC) transporter
AF2641_RS09860	COG1321	iron dependent repressor
AF2641_RS09860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AF2641_RS09865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AF2641_RS09885	COG3853	Toxic anion resistance protein (TelA)
AF2641_RS09905	COG2814	Major facilitator Superfamily
AF2641_RS09910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AF2641_RS09920	COG0840	transmembrane signaling receptor activity
AF2641_RS09920	COG3290	protein histidine kinase activity
AF2641_RS09930	COG2972	Histidine kinase
AF2641_RS09935	COG3279	Response regulator of the LytR AlgR family
AF2641_RS09940	COG4213	ABC transporter substrate-binding protein
AF2641_RS09945	COG1129	ABC transporter
AF2641_RS09950	COG4214	carbohydrate transport
AF2641_RS09980	COG4948	Mandelate Racemase Muconate Lactonizing
AF2641_RS09990	COG4844	belongs to the
AF2641_RS10015	COG0456	acetyltransferase
AF2641_RS10020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AF2641_RS10020	COG3153	acetyltransferase
AF2641_RS10025	COG0386	Belongs to the glutathione peroxidase family
AF2641_RS10030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AF2641_RS10035	COG0438	transferase activity, transferring glycosyl groups
AF2641_RS10045	COG1132	(ABC) transporter
AF2641_RS10050	COG1132	(ABC) transporter
AF2641_RS10065	COG3069	C4-dicarboxylate transmembrane transporter activity
AF2641_RS10070	COG0004	ammonium transporteR
AF2641_RS10080	COG1199	ATP-dependent helicase activity
AF2641_RS10080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AF2641_RS10085	COG0640	Transcriptional regulator
AF2641_RS10095	COG5001	Diguanylate cyclase
AF2641_RS10095	COG3300	MHYT domain
AF2641_RS10115	COG1131	(ABC) transporter
AF2641_RS10125	COG1525	nuclease
AF2641_RS10130	COG1151	hydroxylamine reductase activity
AF2641_RS10135	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AF2641_RS10140	COG0352	thiamine-phosphate diphosphorylase activity
AF2641_RS10145	COG1024	Enoyl-CoA hydratase
AF2641_RS10150	COG2208	phosphoserine phosphatase activity
AF2641_RS10170	COG0840	transmembrane signaling receptor activity
AF2641_RS10195	COG0116	Belongs to the methyltransferase superfamily
AF2641_RS10200	COG1199	ATP-dependent helicase activity
AF2641_RS10205	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AF2641_RS10210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AF2641_RS10215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AF2641_RS10235	COG3424	synthase
AF2641_RS10240	COG1755	Isoprenylcysteine carboxyl methyltransferase
AF2641_RS10245	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AF2641_RS10260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS10280	COG0824	Thioesterase
AF2641_RS10285	COG4841	protein insertion into membrane
AF2641_RS10305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AF2641_RS10320	COG4326	sporulation control protein
AF2641_RS10335	COG0813	purine-nucleoside phosphorylase activity
AF2641_RS10340	COG1876	peptidase activity
AF2641_RS10350	COG2056	Na+-H+ antiporter family
AF2641_RS10355	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AF2641_RS10360	COG2962	Rard protein
AF2641_RS10375	COG0534	Mate efflux family protein
AF2641_RS10380	COG1115	amino acid carrier protein
AF2641_RS10385	COG3852	Histidine kinase
AF2641_RS10395	COG3546	catalase activity
AF2641_RS10400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AF2641_RS10420	COG1725	Transcriptional regulator
AF2641_RS10425	COG1131	(ABC) transporter
AF2641_RS10435	COG0826	peptidase U32
AF2641_RS10445	COG1278	Cold shock
AF2641_RS10460	COG1131	(ABC) transporter
AF2641_RS10465	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AF2641_RS10470	COG0494	nUDIX hydrolase
AF2641_RS10485	COG3341	Caulimovirus viroplasmin
AF2641_RS10485	COG0328	RNA-DNA hybrid ribonuclease activity
AF2641_RS10490	COG0523	cobalamin synthesis protein
AF2641_RS10495	COG0640	Transcriptional regulator
AF2641_RS10500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AF2641_RS10505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AF2641_RS10515	COG1132	(ABC) transporter
AF2641_RS10525	COG1119	ATPase activity
AF2641_RS10570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AF2641_RS10570	COG0551	DNA topoisomerase type I activity
AF2641_RS10585	COG1115	amino acid carrier protein
AF2641_RS10590	COG4548	von Willebrand factor, type A
AF2641_RS10595	COG0714	Associated with various cellular activities
AF2641_RS10600	COG1937	Protein conserved in bacteria
AF2641_RS10610	COG0788	formyltetrahydrofolate deformylase activity
AF2641_RS10615	COG2116	formate transmembrane transporter activity
AF2641_RS10620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AF2641_RS10625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AF2641_RS10630	COG2188	Transcriptional regulator
AF2641_RS10635	COG0366	Alpha amylase catalytic
AF2641_RS10640	COG1263	PTS System
AF2641_RS10640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AF2641_RS10650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AF2641_RS10655	COG0187	DNA topoisomerase II activity
AF2641_RS10660	COG1832	CoA-binding protein
AF2641_RS10665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AF2641_RS10670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AF2641_RS10670	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AF2641_RS10680	COG2755	lipolytic protein G-D-S-L family
AF2641_RS10685	COG1999	signal sequence binding
AF2641_RS10700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AF2641_RS10705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AF2641_RS10710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AF2641_RS10720	COG0409	Hydrogenase expression formation protein
AF2641_RS10725	COG0298	carbon dioxide binding
AF2641_RS10730	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AF2641_RS10735	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AF2641_RS10740	COG0375	protein maturation
AF2641_RS10755	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AF2641_RS10760	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AF2641_RS10770	COG0805	protein transport
AF2641_RS10775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AF2641_RS10785	COG1301	dicarboxylic acid transport
AF2641_RS10795	COG2136	Putative SAM-dependent methyltransferase
AF2641_RS10795	COG2521	methyltransferase
AF2641_RS10805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AF2641_RS10810	COG2814	Major facilitator Superfamily
AF2641_RS10825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AF2641_RS10845	COG1587	Uroporphyrinogen-III synthase
AF2641_RS10850	COG5002	protein histidine kinase activity
AF2641_RS10855	COG0716	FMN binding
AF2641_RS10860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AF2641_RS10860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AF2641_RS10860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AF2641_RS10865	COG1105	Belongs to the carbohydrate kinase PfkB family
AF2641_RS10890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AF2641_RS10895	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AF2641_RS10900	COG0432	Pfam Uncharacterised protein family UPF0047
AF2641_RS10930	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AF2641_RS10940	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AF2641_RS10950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AF2641_RS10975	COG4846	Membrane protein involved in cytochrome C biogenesis
AF2641_RS10980	COG2201	protein-glutamate methylesterase activity
AF2641_RS10985	COG0785	Cytochrome C biogenesis protein
AF2641_RS10990	COG3763	UPF0154 protein
AF2641_RS11000	COG4224	UPF0291 protein
AF2641_RS11005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AF2641_RS11010	COG1388	LysM domain
AF2641_RS11015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AF2641_RS11020	COG0174	glutamine synthetase
AF2641_RS11025	COG0789	Transcriptional regulator
AF2641_RS11030	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AF2641_RS11035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AF2641_RS11040	COG2860	membrane
AF2641_RS11045	COG0183	Belongs to the thiolase family
AF2641_RS11050	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF2641_RS11055	COG0318	PFAM AMP-dependent synthetase and ligase
AF2641_RS11065	COG1960	acyl-CoA dehydrogenase activity
AF2641_RS11075	COG0464	growth
AF2641_RS11080	COG1923	regulation of RNA biosynthetic process
AF2641_RS11085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AF2641_RS11090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AF2641_RS11095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AF2641_RS11105	COG4550	Control of competence regulator ComK, YlbF/YmcA
AF2641_RS11110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AF2641_RS11115	COG1013	pyruvate-flavodoxin oxidoreductase activity
AF2641_RS11120	COG0674	pyruvate-flavodoxin oxidoreductase activity
AF2641_RS11120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AF2641_RS11130	COG2359	stage V sporulation protein S
AF2641_RS11135	COG1692	metallophosphoesterase
AF2641_RS11140	COG1418	mRNA catabolic process
AF2641_RS11150	COG1058	Belongs to the CinA family
AF2641_RS11150	COG1546	Belongs to the CinA family
AF2641_RS11155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AF2641_RS11160	COG1426	Protein conserved in bacteria
AF2641_RS11175	COG0300	oxidoreductase activity
AF2641_RS11180	COG0612	Peptidase, M16
AF2641_RS11185	COG0612	Peptidase, M16
AF2641_RS11190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AF2641_RS11195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AF2641_RS11200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AF2641_RS11215	COG1597	lipid kinase activity
AF2641_RS11220	COG5609	conserved protein (DUF2294)
AF2641_RS11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AF2641_RS11245	COG0371	Dehydrogenase
AF2641_RS11265	COG1742	UPF0060 membrane protein
AF2641_RS11275	COG3852	Histidine kinase
AF2641_RS11300	COG0246	Mannitol dehydrogenase
AF2641_RS11310	COG3711	transcriptional antiterminator
AF2641_RS11320	COG2340	Cysteine-rich secretory protein family
AF2641_RS11330	COG1414	Transcriptional regulator
AF2641_RS11335	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AF2641_RS11350	COG1131	(ABC) transporter
AF2641_RS11365	COG3773	Cell wall hydrolase
AF2641_RS11375	COG1846	Transcriptional regulator
AF2641_RS11380	COG2259	Doxx family
AF2641_RS11385	COG1741	Belongs to the pirin family
AF2641_RS11390	COG1609	Transcriptional regulator
AF2641_RS11395	COG2223	nitrite transmembrane transporter activity
AF2641_RS11405	COG4989	oxidoreductase activity
AF2641_RS11410	COG4377	Putative membrane peptidase family (DUF2324)
AF2641_RS11415	COG5658	integral membrane protein
AF2641_RS11420	COG0640	Transcriptional regulator
AF2641_RS11425	COG0393	Putative heavy-metal-binding
AF2641_RS11430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AF2641_RS11435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AF2641_RS11440	COG0583	DNA-binding transcription factor activity
AF2641_RS11450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AF2641_RS11460	COG1012	belongs to the aldehyde dehydrogenase family
AF2641_RS11470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AF2641_RS11485	COG1192	Involved in chromosome partitioning
AF2641_RS11495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS11500	COG3011	Protein conserved in bacteria
AF2641_RS11515	COG1413	lyase activity
AF2641_RS11545	COG0396	ATPase activity
AF2641_RS11575	COG0579	oxidoreductase
AF2641_RS11600	COG0659	secondary active sulfate transmembrane transporter activity
AF2641_RS11610	COG0589	response to stress
AF2641_RS11615	COG2843	Capsule synthesis protein
AF2641_RS11620	COG2610	gluconate transmembrane transporter activity
AF2641_RS11625	COG0840	transmembrane signaling receptor activity
AF2641_RS11630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AF2641_RS11640	COG1012	belongs to the aldehyde dehydrogenase family
AF2641_RS11645	COG2508	Transcriptional regulator
AF2641_RS11650	COG1079	Belongs to the binding-protein-dependent transport system permease family
AF2641_RS11655	COG4603	Belongs to the binding-protein-dependent transport system permease family
AF2641_RS11660	COG3845	ABC transporter
AF2641_RS11665	COG1744	ABC transporter substrate-binding protein PnrA-like
AF2641_RS11670	COG2188	Transcriptional regulator
AF2641_RS11675	COG1674	ftsk spoiiie
AF2641_RS11675	COG4980	gas vesicle protein
AF2641_RS11685	COG0740	serine-type endopeptidase activity
AF2641_RS11690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AF2641_RS11700	COG0527	aspartate kinase activity
AF2641_RS11705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AF2641_RS11710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AF2641_RS11715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AF2641_RS11720	COG1873	PFAM PRC-barrel domain
AF2641_RS11725	COG0612	Peptidase, M16
AF2641_RS11730	COG0726	polysaccharide deacetylase
AF2641_RS11735	COG1185	polyribonucleotide nucleotidyltransferase activity
AF2641_RS11740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AF2641_RS11745	COG0196	riboflavin kinase activity
AF2641_RS11750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AF2641_RS11755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AF2641_RS11760	COG1550	Protein conserved in bacteria
AF2641_RS11765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AF2641_RS11770	COG1358	cellular component organization or biogenesis
AF2641_RS11775	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AF2641_RS11780	COG0195	Participates in both transcription termination and antitermination
AF2641_RS11785	COG0779	Required for maturation of 30S ribosomal subunits
AF2641_RS11795	COG0442	prolyl-tRNA aminoacylation
AF2641_RS11800	COG0750	zinc metalloprotease
AF2641_RS11805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AF2641_RS11810	COG4589	Belongs to the CDS family
AF2641_RS11815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AF2641_RS11820	COG0233	cytoplasmic translational termination
AF2641_RS11825	COG0528	UMP kinase activity
AF2641_RS11830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AF2641_RS11835	COG0052	Belongs to the universal ribosomal protein uS2 family
AF2641_RS11850	COG1191	sigma factor activity
AF2641_RS11860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AF2641_RS11865	COG1776	CheC inhibitor of MCP methylation
AF2641_RS11870	COG0835	chemotaxis
AF2641_RS11875	COG2198	Histidine kinase
AF2641_RS11875	COG0643	Histidine kinase
AF2641_RS11880	COG2201	protein-glutamate methylesterase activity
AF2641_RS11885	COG0455	bacterial-type flagellum organization
AF2641_RS11890	COG1419	protein localization to endoplasmic reticulum
AF2641_RS11895	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AF2641_RS11900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AF2641_RS11905	COG1684	flagellar biosynthetic protein fliR
AF2641_RS11910	COG1987	bacterial-type flagellum assembly
AF2641_RS11915	COG1338	Plays a role in the flagellum-specific transport system
AF2641_RS11920	COG3190	flagellar
AF2641_RS11925	COG2201	protein-glutamate methylesterase activity
AF2641_RS11930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AF2641_RS11930	COG1776	CheC inhibitor of MCP methylation
AF2641_RS11935	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AF2641_RS11940	COG1580	Controls the rotational direction of flagella during chemotaxis
AF2641_RS11945	COG1582	Flagellar protein (FlbD)
AF2641_RS11950	COG4786	Flagellar basal body rod
AF2641_RS11960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AF2641_RS11965	COG3144	bacterial-type flagellum assembly
AF2641_RS11975	COG2882	bacterial-type flagellum organization
AF2641_RS11980	COG1157	protein secretion by the type III secretion system
AF2641_RS11985	COG1317	bacterial-type flagellum organization
AF2641_RS11990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AF2641_RS11995	COG1766	The M ring may be actively involved in energy transduction
AF2641_RS12000	COG1677	Flagellar hook-basal body complex protein FliE
AF2641_RS12005	COG1558	bacterial-type flagellum-dependent cell motility
AF2641_RS12010	COG1815	bacterial-type flagellum-dependent cell motility
AF2641_RS12015	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AF2641_RS12020	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AF2641_RS12025	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AF2641_RS12030	COG4974	Belongs to the 'phage' integrase family
AF2641_RS12035	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AF2641_RS12040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AF2641_RS12045	COG0758	DNA mediated transformation
AF2641_RS12050	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AF2641_RS12055	COG0045	succinate-CoA ligase (ADP-forming) activity
AF2641_RS12060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AF2641_RS12070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AF2641_RS12075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AF2641_RS12085	COG0335	large ribosomal subunit rRNA binding
AF2641_RS12090	COG0336	Belongs to the RNA methyltransferase TrmD family
AF2641_RS12095	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AF2641_RS12105	COG1837	Belongs to the UPF0109 family
AF2641_RS12110	COG0228	four-way junction DNA binding
AF2641_RS12115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AF2641_RS12120	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AF2641_RS12125	COG0552	protein localization to endoplasmic reticulum
AF2641_RS12130	COG1196	nuclear chromosome segregation
AF2641_RS12135	COG0571	ribonuclease III activity
AF2641_RS12140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AF2641_RS12145	COG1028	Short-chain dehydrogenase reductase Sdr
AF2641_RS12150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AF2641_RS12155	COG0416	fatty acid biosynthetic process
AF2641_RS12160	COG1349	DNA-binding transcription factor activity
AF2641_RS12165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AF2641_RS12170	COG1760	l-serine dehydratase
AF2641_RS12175	COG1760	l-serine dehydratase
AF2641_RS12180	COG1461	Dihydroxyacetone kinase
AF2641_RS12185	COG1302	Protein conserved in bacteria
AF2641_RS12190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AF2641_RS12200	COG1564	THIamine pyrophosphokinase
AF2641_RS12205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AF2641_RS12210	COG1162	GTPase activity
AF2641_RS12215	COG2815	serine threonine protein kinase
AF2641_RS12215	COG0515	serine threonine protein kinase
AF2641_RS12220	COG0631	protein serine/threonine phosphatase activity
AF2641_RS12225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AF2641_RS12230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AF2641_RS12230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AF2641_RS12235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AF2641_RS12240	COG0242	peptide deformylase activity
AF2641_RS12245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AF2641_RS12250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AF2641_RS12255	COG1758	RNA polymerase activity
AF2641_RS12260	COG0194	GDP metabolic process
AF2641_RS12265	COG1561	YicC-like family, N-terminal region
AF2641_RS12270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AF2641_RS12275	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AF2641_RS12330	COG0284	orotidine-5'-phosphate decarboxylase activity
AF2641_RS12335	COG0167	dihydroorotate dehydrogenase activity
AF2641_RS12340	COG0543	2 iron, 2 sulfur cluster binding
AF2641_RS12355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AF2641_RS12360	COG0540	Belongs to the ATCase OTCase family
AF2641_RS12370	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AF2641_RS12375	COG0564	pseudouridine synthase activity
AF2641_RS12380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AF2641_RS12390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AF2641_RS12395	COG3599	regulation of cell shape
AF2641_RS12400	COG2302	S4 RNA-binding domain
AF2641_RS12405	COG0762	integral membrane protein
AF2641_RS12410	COG1799	cell septum assembly
AF2641_RS12415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AF2641_RS12425	COG1873	PFAM PRC-barrel domain
AF2641_RS12430	COG1191	sigma factor activity
AF2641_RS12435	COG1191	sigma factor activity
AF2641_RS12445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AF2641_RS12450	COG0849	cell division
AF2641_RS12455	COG3856	small basic protein
AF2641_RS12460	COG3879	Bacterial protein of unknown function (DUF881)
AF2641_RS12465	COG3879	Bacterial protein of unknown function (DUF881)
AF2641_RS12470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AF2641_RS12475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AF2641_RS12480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AF2641_RS12485	COG0772	Belongs to the SEDS family
AF2641_RS12490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AF2641_RS12495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AF2641_RS12500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AF2641_RS12505	COG0768	penicillin binding
AF2641_RS12510	COG0768	penicillin binding
AF2641_RS12515	COG4839	cell division protein FtsL
AF2641_RS12520	COG0275	rRNA processing
AF2641_RS12525	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AF2641_RS12535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AF2641_RS12545	COG1250	3-hydroxyacyl-CoA dehydrogenase
AF2641_RS12545	COG1024	Enoyl-CoA hydratase
AF2641_RS12550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AF2641_RS12555	COG1399	metal-binding, possibly nucleic acid-binding protein
AF2641_RS12560	COG1323	Belongs to the UPF0348 family
AF2641_RS12565	COG3480	Lon protease (S16) C-terminal proteolytic domain
AF2641_RS12570	COG1752	Esterase of the alpha-beta hydrolase superfamily
AF2641_RS12575	COG3314	Sporulation integral membrane protein YlbJ
AF2641_RS12580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AF2641_RS12585	COG0742	ribosomal rna small subunit methyltransferase
AF2641_RS12600	COG4471	UPF0298 protein
AF2641_RS12605	COG3679	Belongs to the UPF0342 family
AF2641_RS12625	COG2340	Cysteine-rich secretory protein family
AF2641_RS12630	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AF2641_RS12645	COG0628	permease
AF2641_RS12655	COG3336	cytochrome c oxidase
AF2641_RS12680	COG0109	protoheme IX farnesyltransferase activity
AF2641_RS12685	COG1612	heme a metabolic process
AF2641_RS12690	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AF2641_RS12695	COG0772	Belongs to the SEDS family
AF2641_RS12700	COG4838	Belongs to the UPF0358 family
AF2641_RS12705	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AF2641_RS12710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AF2641_RS12740	COG1217	gtp-binding protein TYPA
AF2641_RS12750	COG0483	inositol monophosphate 1-phosphatase activity
AF2641_RS12760	COG4476	Belongs to the UPF0223 family
AF2641_RS12770	COG1982	Orn Lys Arg decarboxylase major
AF2641_RS12820	COG0561	phosphatase activity
AF2641_RS12825	COG5503	Protein of unknown function (DUF1447)
AF2641_RS12830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AF2641_RS12840	COG0569	domain protein
AF2641_RS12845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS12850	COG1473	amidohydrolase
AF2641_RS12855	COG2171	N-acyltransferase activity
AF2641_RS12860	COG0517	IMP dehydrogenase activity
AF2641_RS12865	COG4703	Protein of unknown function (DUF1797)
AF2641_RS12875	COG2200	EAL domain
AF2641_RS12880	COG1028	Short-chain dehydrogenase reductase Sdr
AF2641_RS12885	COG1408	metallophosphoesterase
AF2641_RS12890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AF2641_RS12895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AF2641_RS12905	COG0248	Ppx GppA phosphatase
AF2641_RS12935	COG5002	protein histidine kinase activity
AF2641_RS12940	COG0745	RESPONSE REGULATOR receiver
AF2641_RS12950	COG1215	transferase activity, transferring glycosyl groups
AF2641_RS12965	COG0835	chemotaxis
AF2641_RS12965	COG0784	Response regulator, receiver
AF2641_RS12980	COG2205	protein histidine kinase activity
AF2641_RS12995	COG0436	Aminotransferase
AF2641_RS13000	COG2084	Dehydrogenase
AF2641_RS13005	COG1028	Short-chain dehydrogenase reductase Sdr
AF2641_RS13010	COG4221	oxidoreductase activity
AF2641_RS13020	COG2205	protein histidine kinase activity
AF2641_RS13025	COG0840	transmembrane signaling receptor activity
AF2641_RS13040	COG1263	PTS System
AF2641_RS13040	COG2190	(PTS) system
AF2641_RS13040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AF2641_RS13045	COG3711	transcriptional antiterminator
AF2641_RS13050	COG0561	phosphatase activity
AF2641_RS13055	COG1388	LysM domain
AF2641_RS13055	COG3942	CHAP domain
AF2641_RS13070	COG1320	monovalent cation:proton antiporter activity
AF2641_RS13075	COG2212	antiporter activity
AF2641_RS13080	COG1863	multisubunit Na H antiporter MnhE subunit
AF2641_RS13085	COG0651	ATP synthesis coupled electron transport
AF2641_RS13090	COG1006	Multisubunit Na H antiporter MnhC subunit
AF2641_RS13095	COG2111	Na H antiporter
AF2641_RS13100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AF2641_RS13100	COG2111	Na H antiporter
AF2641_RS13105	COG0840	transmembrane signaling receptor activity
AF2641_RS13125	COG1733	regulation of RNA biosynthetic process
AF2641_RS13130	COG0778	Nitroreductase
AF2641_RS13135	COG3852	Histidine kinase
AF2641_RS13160	COG4873	Protein conserved in bacteria
AF2641_RS13165	COG0702	epimerase
AF2641_RS13180	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AF2641_RS13190	COG0720	synthase
AF2641_RS13195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AF2641_RS13200	COG0704	Plays a role in the regulation of phosphate uptake
AF2641_RS13220	COG3949	Membrane
AF2641_RS13235	COG0745	RESPONSE REGULATOR receiver
AF2641_RS13240	COG5002	protein histidine kinase activity
AF2641_RS13250	COG0542	response to heat
AF2641_RS13265	COG1131	(ABC) transporter
AF2641_RS13270	COG0531	amino acid
AF2641_RS13285	COG3852	Histidine kinase
AF2641_RS13295	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AF2641_RS13300	COG0235	Class ii aldolase
AF2641_RS13305	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AF2641_RS13310	COG1850	ribulose-bisphosphate carboxylase activity
AF2641_RS13315	COG0436	Aminotransferase
AF2641_RS13320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AF2641_RS13325	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AF2641_RS13330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AF2641_RS13335	COG1879	ABC-type sugar transport system periplasmic component
AF2641_RS13340	COG1129	ABC transporter
AF2641_RS13350	COG0840	transmembrane signaling receptor activity
AF2641_RS13355	COG5002	protein histidine kinase activity
AF2641_RS13360	COG1556	Lactate utilization protein
AF2641_RS13365	COG1139	Iron-sulfur cluster binding protein
AF2641_RS13370	COG0247	lactate metabolic process
AF2641_RS13375	COG2186	Transcriptional regulator
AF2641_RS13380	COG1620	l-lactate permease
AF2641_RS13425	COG0395	ABC-type sugar transport system, permease component
AF2641_RS13440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AF2641_RS13445	COG1554	hydrolase, family 65, central catalytic
AF2641_RS13450	COG1609	Transcriptional regulator
AF2641_RS13460	COG0840	transmembrane signaling receptor activity
AF2641_RS13465	COG3835	regulator
AF2641_RS13470	COG0277	FAD linked oxidase domain protein
AF2641_RS13475	COG0247	lactate metabolic process
AF2641_RS13485	COG1528	Iron-storage protein
AF2641_RS13490	COG0861	Integral membrane protein TerC family
AF2641_RS13495	COG0531	amino acid
AF2641_RS13510	COG0463	Glycosyl transferase, family 2
AF2641_RS13520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AF2641_RS13525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AF2641_RS13540	COG2610	gluconate transmembrane transporter activity
AF2641_RS13550	COG1609	Transcriptional regulator
AF2641_RS13570	COG1027	Aspartate ammonia-lyase
AF2641_RS13575	COG0252	asparaginase activity
AF2641_RS13580	COG1396	sequence-specific DNA binding
AF2641_RS13585	COG0515	serine threonine protein kinase
AF2641_RS13600	COG0697	spore germination
AF2641_RS13605	COG2337	Toxic component of a toxin-antitoxin (TA) module
AF2641_RS13610	COG2336	PFAM SpoVT AbrB
AF2641_RS13620	COG0494	nUDIX hydrolase
AF2641_RS13625	COG1132	(ABC) transporter
AF2641_RS13630	COG1132	(ABC) transporter
AF2641_RS13645	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AF2641_RS13645	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AF2641_RS13670	COG0367	asparagine synthase
AF2641_RS13675	COG4990	cell redox homeostasis
AF2641_RS13680	COG2132	Multicopper oxidase
AF2641_RS13690	COG2217	Heavy metal translocating P-type atpase
AF2641_RS13695	COG1937	Protein conserved in bacteria
AF2641_RS13700	COG0785	Cytochrome C biogenesis protein
AF2641_RS13705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS13730	COG0745	RESPONSE REGULATOR receiver
AF2641_RS13735	COG3850	Histidine kinase
AF2641_RS13735	COG5002	protein histidine kinase activity
AF2641_RS13845	COG0813	purine-nucleoside phosphorylase activity
AF2641_RS13875	COG1595	DNA-templated transcription, initiation
AF2641_RS13925	COG0582	viral genome integration into host DNA
AF2641_RS13940	COG1418	mRNA catabolic process
AF2641_RS13945	COG0626	cystathionine gamma-synthase activity
AF2641_RS13950	COG0626	cystathionine gamma-synthase activity
AF2641_RS13955	COG0662	Cupin 2, conserved barrel domain protein
AF2641_RS13960	COG1970	mechanosensitive ion channel activity
AF2641_RS13965	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AF2641_RS13970	COG2382	esterase
AF2641_RS13975	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AF2641_RS13980	COG2153	protein acetylation
AF2641_RS13985	COG2323	membrane
AF2641_RS13990	COG0210	DNA helicase
AF2641_RS14010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AF2641_RS14015	COG2323	membrane
AF2641_RS14030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AF2641_RS14085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AF2641_RS14090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AF2641_RS14095	COG0438	transferase activity, transferring glycosyl groups
AF2641_RS14110	COG2814	Major facilitator Superfamily
AF2641_RS14120	COG2239	Acts as a magnesium transporter
AF2641_RS14125	COG0772	Belongs to the SEDS family
AF2641_RS14140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AF2641_RS14145	COG0564	pseudouridine synthase activity
AF2641_RS14155	COG2357	RelA SpoT domain protein
AF2641_RS14165	COG4116	CYTH
AF2641_RS14170	COG0741	lytic transglycosylase activity
AF2641_RS14175	COG2346	COG2346, Truncated hemoglobins
AF2641_RS14180	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AF2641_RS14185	COG1164	Oligoendopeptidase f
AF2641_RS14195	COG4862	establishment of competence for transformation
AF2641_RS14200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AF2641_RS14205	COG1393	Belongs to the ArsC family
AF2641_RS14215	COG4608	Belongs to the ABC transporter superfamily
AF2641_RS14220	COG0444	Belongs to the ABC transporter superfamily
AF2641_RS14225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AF2641_RS14230	COG0601	transmembrane transport
AF2641_RS14235	COG4166	transmembrane transport
AF2641_RS14250	COG0180	Tryptophanyl-tRNA synthetase
AF2641_RS14265	COG5504	Zn-dependent protease
AF2641_RS14270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AF2641_RS14275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AF2641_RS14280	COG1744	ABC transporter substrate-binding protein PnrA-like
AF2641_RS14285	COG2267	carboxylic ester hydrolase activity
AF2641_RS14295	COG0542	response to heat
AF2641_RS14305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AF2641_RS14325	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AF2641_RS14330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AF2641_RS14335	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AF2641_RS14340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AF2641_RS14350	COG1073	alpha beta
AF2641_RS14355	COG0561	phosphatase activity
AF2641_RS14365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AF2641_RS14370	COG1307	EDD domain protein, DegV family
AF2641_RS14380	COG0840	transmembrane signaling receptor activity
AF2641_RS14385	COG1744	ABC transporter substrate-binding protein PnrA-like
AF2641_RS14390	COG1666	GTP binding
AF2641_RS14395	COG0646	methionine synthase
AF2641_RS14395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AF2641_RS14400	COG1410	methionine synthase
AF2641_RS14400	COG0646	methionine synthase
AF2641_RS14415	COG0366	Alpha amylase catalytic
AF2641_RS14415	COG1874	Beta-galactosidase
AF2641_RS14420	COG3833	ABC-type maltose transport systems, permease component
AF2641_RS14425	COG1175	transmembrane transport
AF2641_RS14430	COG2182	Extracellular solute-binding protein
AF2641_RS14440	COG1917	Cupin 2, conserved barrel domain protein
AF2641_RS14440	COG2207	Transcriptional regulator
AF2641_RS14445	COG0534	Mate efflux family protein
AF2641_RS14450	COG1233	COG1233 Phytoene dehydrogenase and related
AF2641_RS14455	COG0463	Glycosyl transferase, family 2
AF2641_RS14470	COG1562	ergosterol biosynthetic process
AF2641_RS14485	COG0367	asparagine synthase
AF2641_RS14495	COG3300	MHYT domain
AF2641_RS14495	COG5001	Diguanylate cyclase
AF2641_RS14505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AF2641_RS14510	COG0179	Fumarylacetoacetate (FAA) hydrolase
AF2641_RS14520	COG2311	Membrane
AF2641_RS14525	COG0318	PFAM AMP-dependent synthetase and ligase
AF2641_RS14565	COG1403	HNH endonuclease
AF2641_RS14570	COG0419	ATPase involved in DNA repair
AF2641_RS14575	COG0420	3'-5' exonuclease activity
AF2641_RS14580	COG1074	ATP-dependent DNA helicase activity
AF2641_RS14585	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AF2641_RS14590	COG0398	Pfam SNARE associated Golgi protein
AF2641_RS14595	COG4903	ComK protein
AF2641_RS14600	COG2224	Isocitrate lyase
AF2641_RS14605	COG0501	Belongs to the peptidase M48B family
AF2641_RS14610	COG1999	signal sequence binding
AF2641_RS14615	COG0840	transmembrane signaling receptor activity
AF2641_RS14620	COG0840	transmembrane signaling receptor activity
AF2641_RS14635	COG4120	Belongs to the binding-protein-dependent transport system permease family