locus-tag	class	description
AFLV_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFLV_RS00020	COG0592	DNA-directed DNA polymerase activity
AFLV_RS00025	COG2501	S4 domain
AFLV_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFLV_RS00035	COG0187	DNA topoisomerase II activity
AFLV_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFLV_RS00080	COG0516	GMP reductase activity
AFLV_RS00080	COG0517	IMP dehydrogenase activity
AFLV_RS00090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AFLV_RS00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AFLV_RS00100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFLV_RS00110	COG1428	Deoxynucleoside kinase
AFLV_RS00115	COG1428	Deoxynucleoside kinase
AFLV_RS00120	COG0590	tRNA wobble adenosine to inosine editing
AFLV_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AFLV_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AFLV_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFLV_RS00180	COG1982	Orn Lys Arg decarboxylase major
AFLV_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFLV_RS00190	COG0470	DNA polymerase III
AFLV_RS00195	COG1774	PSP1 C-terminal conserved region
AFLV_RS00200	COG4467	Involved in initiation control of chromosome replication
AFLV_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AFLV_RS00210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AFLV_RS00215	COG2002	toxin-antitoxin pair type II binding
AFLV_RS00225	COG0084	hydrolase, TatD family'
AFLV_RS00230	COG3584	3D domain protein
AFLV_RS00230	COG3583	domain protein
AFLV_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFLV_RS00250	COG4466	Protein conserved in bacteria
AFLV_RS00255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFLV_RS00260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFLV_RS00265	COG0251	oxidation-reduction process
AFLV_RS00270	COG2088	sporulation resulting in formation of a cellular spore
AFLV_RS00275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFLV_RS00285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFLV_RS00290	COG0193	aminoacyl-tRNA hydrolase activity
AFLV_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AFLV_RS00305	COG2002	toxin-antitoxin pair type II binding
AFLV_RS00310	COG2244	polysaccharide biosynthetic process
AFLV_RS00315	COG3956	TIGRFAM MazG family protein
AFLV_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AFLV_RS00340	COG1098	S1 RNA binding domain
AFLV_RS00355	COG2208	phosphoserine phosphatase activity
AFLV_RS00360	COG2304	oxidoreductase activity
AFLV_RS00365	COG0515	serine threonine protein kinase
AFLV_RS00370	COG0037	tRNA processing
AFLV_RS00375	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AFLV_RS00380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFLV_RS00385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFLV_RS00390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AFLV_RS00395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFLV_RS00400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AFLV_RS00405	COG0512	Glutamine amidotransferase of anthranilate synthase
AFLV_RS00410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFLV_RS00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFLV_RS00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AFLV_RS00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AFLV_RS00430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AFLV_RS00460	COG3880	PFAM UvrB UvrC protein
AFLV_RS00465	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AFLV_RS00470	COG0542	response to heat
AFLV_RS00475	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AFLV_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
AFLV_RS00485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFLV_RS00490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFLV_RS00495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFLV_RS00500	COG1045	serine acetyltransferase
AFLV_RS00505	COG0215	cysteine-tRNA ligase activity
AFLV_RS00510	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AFLV_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFLV_RS00520	COG3688	RNA-binding protein containing a PIN domain
AFLV_RS00530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFLV_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFLV_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
AFLV_RS00550	COG0081	regulation of translation
AFLV_RS00555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFLV_RS00560	COG0222	ribosome binding
AFLV_RS00565	COG2813	Specifically methylates the guanine in position
AFLV_RS00570	COG0085	RNA polymerase activity
AFLV_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFLV_RS00580	COG1358	cellular component organization or biogenesis
AFLV_RS00585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFLV_RS00590	COG0049	tRNA binding
AFLV_RS00595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFLV_RS00600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFLV_RS00610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFLV_RS00615	COG0088	Forms part of the polypeptide exit tunnel
AFLV_RS00620	COG0089	rRNA binding
AFLV_RS00625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFLV_RS00630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFLV_RS00635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFLV_RS00640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AFLV_RS00645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFLV_RS00655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFLV_RS00660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFLV_RS00665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFLV_RS00670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFLV_RS00675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFLV_RS00680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFLV_RS00685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFLV_RS00690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFLV_RS00695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFLV_RS00700	COG1841	ribosomal large subunit assembly
AFLV_RS00705	COG0200	Binds to the 23S rRNA
AFLV_RS00710	COG0201	protein transport
AFLV_RS00715	COG0563	adenylate kinase activity
AFLV_RS00720	COG0024	Methionine aminopeptidase
AFLV_RS00725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFLV_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AFLV_RS00735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFLV_RS00740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFLV_RS00745	COG0202	RNA polymerase activity
AFLV_RS00750	COG0203	ribosomal protein L17
AFLV_RS00755	COG1122	ATPase activity
AFLV_RS00760	COG1122	ATPase activity
AFLV_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AFLV_RS00770	COG0101	tRNA pseudouridine synthase activity
AFLV_RS00775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFLV_RS00780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFLV_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFLV_RS00795	COG0489	protein tyrosine kinase activity
AFLV_RS00805	COG2194	sulfuric ester hydrolase activity
AFLV_RS00810	COG0726	polysaccharide deacetylase
AFLV_RS00885	COG1595	DNA-templated transcription, initiation
AFLV_RS00890	COG5662	AntiSigma factor
AFLV_RS00895	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AFLV_RS00900	COG4856	YbbR-like protein
AFLV_RS00905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFLV_RS00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFLV_RS00945	COG0204	Acyl-transferase
AFLV_RS00955	COG0736	holo-[acyl-carrier-protein] synthase activity
AFLV_RS01000	COG2336	PFAM SpoVT AbrB
AFLV_RS01040	COG2197	response regulator
AFLV_RS01045	COG0789	Transcriptional regulator
AFLV_RS01050	COG0492	ferredoxin-NADP+ reductase activity
AFLV_RS01060	COG1966	Carbon starvation protein
AFLV_RS01075	COG1960	acyl-CoA dehydrogenase activity
AFLV_RS01080	COG0318	PFAM AMP-dependent synthetase and ligase
AFLV_RS01085	COG0439	Biotin carboxylase
AFLV_RS01090	COG0511	ligase activity, forming carbon-carbon bonds
AFLV_RS01095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFLV_RS01100	COG1024	Enoyl-CoA hydratase
AFLV_RS01105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFLV_RS01120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFLV_RS01140	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFLV_RS01145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AFLV_RS01150	COG0513	Belongs to the DEAD box helicase family
AFLV_RS01155	COG0736	holo-[acyl-carrier-protein] synthase activity
AFLV_RS01160	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AFLV_RS01165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFLV_RS01170	COG0864	Transcriptional regulator
AFLV_RS01175	COG2337	Toxic component of a toxin-antitoxin (TA) module
AFLV_RS01180	COG2183	response to ionizing radiation
AFLV_RS01185	COG3091	SprT-like family
AFLV_RS01225	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFLV_RS01270	COG0802	atpase or kinase
AFLV_RS01275	COG1214	PFAM Peptidase M22, glycoprotease
AFLV_RS01280	COG0456	acetyltransferase
AFLV_RS01285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFLV_RS01295	COG0488	(ABC) transporter
AFLV_RS01300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AFLV_RS01310	COG1266	CAAX protease self-immunity
AFLV_RS01315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFLV_RS01320	COG0459	protein refolding
AFLV_RS01340	COG0367	asparagine synthase
AFLV_RS01345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFLV_RS01350	COG0151	Belongs to the GarS family
AFLV_RS01355	COG0010	Belongs to the arginase family
AFLV_RS01375	COG2814	Major facilitator Superfamily
AFLV_RS01380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AFLV_RS01380	COG0165	Argininosuccinate lyase
AFLV_RS01390	COG0519	Catalyzes the synthesis of GMP from XMP
AFLV_RS01390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFLV_RS01395	COG2252	PERMEase
AFLV_RS01415	COG0071	Belongs to the small heat shock protein (HSP20) family
AFLV_RS01420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AFLV_RS01425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AFLV_RS01430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFLV_RS01435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AFLV_RS01440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFLV_RS01445	COG0047	phosphoribosylformylglycinamidine synthase activity
AFLV_RS01450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFLV_RS01455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AFLV_RS01460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFLV_RS01465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AFLV_RS01470	COG0138	bifunctional purine biosynthesis protein purh
AFLV_RS01475	COG0151	Belongs to the GarS family
AFLV_RS01485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AFLV_RS01490	COG1470	cell adhesion involved in biofilm formation
AFLV_RS01495	COG4496	protein, YerC YecD
AFLV_RS01500	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AFLV_RS01510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFLV_RS01515	COG4851	CamS sex pheromone cAM373 precursor
AFLV_RS01520	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS01530	COG3335	DDE superfamily endonuclease
AFLV_RS01560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AFLV_RS01565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFLV_RS01570	COG0154	amidase activity
AFLV_RS01575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFLV_RS01595	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AFLV_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS01665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFLV_RS01680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AFLV_RS01685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AFLV_RS01695	COG1842	Phage shock protein A
AFLV_RS01705	COG5002	protein histidine kinase activity
AFLV_RS01715	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFLV_RS01725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFLV_RS01730	COG4585	Histidine kinase
AFLV_RS01740	COG0730	response to heat
AFLV_RS01745	COG1597	lipid kinase activity
AFLV_RS01755	COG2211	Major facilitator Superfamily
AFLV_RS01795	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AFLV_RS01800	COG0840	transmembrane signaling receptor activity
AFLV_RS01810	COG0791	NLP P60 protein
AFLV_RS01810	COG1388	LysM domain
AFLV_RS01815	COG0861	Integral membrane protein TerC family
AFLV_RS01820	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFLV_RS01825	COG0010	Belongs to the arginase family
AFLV_RS01845	COG1254	Belongs to the acylphosphatase family
AFLV_RS01855	COG1648	precorrin-2 dehydrogenase activity
AFLV_RS01870	COG0529	Catalyzes the synthesis of activated sulfate
AFLV_RS01875	COG2046	Belongs to the sulfate adenylyltransferase family
AFLV_RS01880	COG0306	phosphate transporter
AFLV_RS01885	COG0175	sulfate reduction
AFLV_RS01895	COG4840	Belongs to the UPF0435 family
AFLV_RS01900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFLV_RS01910	COG1295	ribonuclease BN
AFLV_RS01920	COG0477	Major facilitator Superfamily
AFLV_RS01925	COG0387	Pfam Sodium calcium exchanger
AFLV_RS01935	COG0535	radical SAM domain protein
AFLV_RS01955	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AFLV_RS01965	COG1051	belongs to the nudix hydrolase family
AFLV_RS01975	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AFLV_RS02000	COG0840	transmembrane signaling receptor activity
AFLV_RS02020	COG1090	epimerase
AFLV_RS02025	COG2137	regulation of response to DNA damage stimulus
AFLV_RS02030	COG4221	oxidoreductase activity
AFLV_RS02035	COG1620	l-lactate permease
AFLV_RS02050	COG1988	membrane-bound metal-dependent
AFLV_RS02070	COG3557	Belongs to the UPF0374 family
AFLV_RS02075	COG0444	Belongs to the ABC transporter superfamily
AFLV_RS02080	COG4608	Belongs to the ABC transporter superfamily
AFLV_RS02085	COG0747	negative chemotaxis
AFLV_RS02090	COG0601	transmembrane transport
AFLV_RS02095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFLV_RS02100	COG4129	membrane
AFLV_RS02105	COG0067	glutamate synthase
AFLV_RS02105	COG0070	glutamate synthase
AFLV_RS02105	COG0069	glutamate synthase activity
AFLV_RS02110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFLV_RS02115	COG4555	ABC transporter
AFLV_RS02135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AFLV_RS02140	COG0735	belongs to the Fur family
AFLV_RS02200	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFLV_RS02290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFLV_RS02295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AFLV_RS02300	COG0297	glycogen (starch) synthase activity
AFLV_RS02305	COG0058	SHG alpha-glucan phosphorylase activity
AFLV_RS02310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AFLV_RS02315	COG1575	Belongs to the MenA family. Type 1 subfamily
AFLV_RS02320	COG1169	isochorismate synthase
AFLV_RS02325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AFLV_RS02330	COG0596	Alpha beta hydrolase
AFLV_RS02335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AFLV_RS02340	COG0318	PFAM AMP-dependent synthetase and ligase
AFLV_RS02345	COG1294	oxidase, subunit
AFLV_RS02350	COG1271	oxidase subunit
AFLV_RS02365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFLV_RS02370	COG0716	FMN binding
AFLV_RS02380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFLV_RS02385	COG1294	oxidase, subunit
AFLV_RS02390	COG1271	oxidase subunit
AFLV_RS02395	COG3443	Belongs to the bacterial solute-binding protein 9 family
AFLV_RS02395	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFLV_RS02400	COG0523	cobalamin synthesis protein
AFLV_RS02405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AFLV_RS02410	COG1854	S-ribosylhomocysteine lyase activity
AFLV_RS02415	COG0783	Belongs to the Dps family
AFLV_RS02425	COG0494	nUDIX hydrolase
AFLV_RS02430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFLV_RS02435	COG1116	anion transmembrane transporter activity
AFLV_RS02440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AFLV_RS02455	COG1122	ATPase activity
AFLV_RS02465	COG0310	cobalt ion transport
AFLV_RS02475	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AFLV_RS02480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFLV_RS02485	COG0671	phosphoesterase, PA-phosphatase related
AFLV_RS02490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AFLV_RS02495	COG2267	carboxylic ester hydrolase activity
AFLV_RS02510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AFLV_RS02515	COG1242	4 iron, 4 sulfur cluster binding
AFLV_RS02530	COG0495	leucyl-tRNA aminoacylation
AFLV_RS02535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFLV_RS02540	COG2081	HI0933 family
AFLV_RS02545	COG2244	polysaccharide biosynthetic process
AFLV_RS02555	COG1187	pseudouridine synthase activity
AFLV_RS02560	COG1349	DNA-binding transcription factor activity
AFLV_RS02565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFLV_RS02580	COG1380	Effector of murein hydrolase LrgA
AFLV_RS02585	COG1346	cytolysis
AFLV_RS02595	COG1523	belongs to the glycosyl hydrolase 13 family
AFLV_RS02600	COG0510	thiamine kinase activity
AFLV_RS02610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AFLV_RS02615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFLV_RS02625	COG1363	Peptidase, m42
AFLV_RS02630	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AFLV_RS02635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFLV_RS02640	COG4848	Belongs to the UPF0354 family
AFLV_RS02645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFLV_RS02650	COG1674	ftsk spoiiie
AFLV_RS02650	COG1674	ftsk spoiiie
AFLV_RS02660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFLV_RS02665	COG3118	belongs to the thioredoxin family
AFLV_RS02675	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AFLV_RS02680	COG2309	aminopeptidase activity
AFLV_RS02690	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AFLV_RS02690	COG1605	Chorismate mutase
AFLV_RS02700	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFLV_RS02705	COG0517	IMP dehydrogenase activity
AFLV_RS02710	COG0454	-acetyltransferase
AFLV_RS02715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFLV_RS02730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFLV_RS02735	COG2203	Gaf domain
AFLV_RS02735	COG2199	diguanylate cyclase activity
AFLV_RS02740	COG1956	GAF domain-containing protein
AFLV_RS02745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFLV_RS02750	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AFLV_RS02755	COG1114	Component of the transport system for branched-chain amino acids
AFLV_RS02760	COG1104	cysteine desulfurase activity
AFLV_RS02765	COG0301	tRNA thio-modification
AFLV_RS02775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFLV_RS02780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFLV_RS02790	COG3874	Sporulation protein YtfJ
AFLV_RS02795	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AFLV_RS02800	COG0827	DNA restriction-modification system
AFLV_RS02805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AFLV_RS02815	COG0137	argininosuccinate synthase activity
AFLV_RS02820	COG0165	Argininosuccinate lyase
AFLV_RS02825	COG0589	response to stress
AFLV_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
AFLV_RS02835	COG0006	proline dipeptidase activity
AFLV_RS02840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AFLV_RS02845	COG4109	DRTGG domain
AFLV_RS02855	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AFLV_RS02870	COG0587	DNA-directed DNA polymerase activity
AFLV_RS02875	COG0281	malic enzyme
AFLV_RS02885	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AFLV_RS02890	COG0825	malonyl-CoA metabolic process
AFLV_RS02895	COG0205	6-phosphofructokinase activity
AFLV_RS02905	COG3030	protein affecting phage T7 exclusion by the F plasmid
AFLV_RS02910	COG0628	permease
AFLV_RS02915	COG2707	UPF0756 membrane protein
AFLV_RS02920	COG0372	Belongs to the citrate synthase family
AFLV_RS02925	COG0538	isocitrate dehydrogenase activity
AFLV_RS02930	COG0039	L-malate dehydrogenase activity
AFLV_RS02940	COG0745	RESPONSE REGULATOR receiver
AFLV_RS02945	COG5002	protein histidine kinase activity
AFLV_RS02955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFLV_RS02960	COG1971	Probably functions as a manganese efflux pump
AFLV_RS02970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFLV_RS02975	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AFLV_RS02985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFLV_RS02990	COG3611	Membrane attachment protein
AFLV_RS02995	COG1484	DNA-dependent DNA replication
AFLV_RS03005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFLV_RS03015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFLV_RS03020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFLV_RS03035	COG1363	Peptidase, m42
AFLV_RS03050	COG1069	ribulokinase activity
AFLV_RS03055	COG2160	L-arabinose isomerase activity
AFLV_RS03080	COG1609	Transcriptional regulator
AFLV_RS03095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AFLV_RS03100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFLV_RS03105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFLV_RS03110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFLV_RS03110	COG0072	phenylalanine-tRNA ligase activity
AFLV_RS03125	COG1131	(ABC) transporter
AFLV_RS03150	COG4585	Histidine kinase
AFLV_RS03155	COG2197	response regulator
AFLV_RS03180	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AFLV_RS03195	COG2409	Drug exporters of the RND superfamily
AFLV_RS03195	COG1033	growth of symbiont in host cell
AFLV_RS03200	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AFLV_RS03205	COG1286	toxin biosynthetic process
AFLV_RS03210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFLV_RS03210	COG1796	DNA polymerase
AFLV_RS03215	COG1193	negative regulation of DNA recombination
AFLV_RS03220	COG3766	membrane
AFLV_RS03225	COG0318	PFAM AMP-dependent synthetase and ligase
AFLV_RS03230	COG1309	transcriptional regulator
AFLV_RS03235	COG1024	Enoyl-CoA hydratase
AFLV_RS03240	COG2086	electron transfer activity
AFLV_RS03245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFLV_RS03250	COG3118	belongs to the thioredoxin family
AFLV_RS03260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFLV_RS03295	COG0322	excinuclease ABC activity
AFLV_RS03300	COG1719	4-vinyl reductase, 4VR
AFLV_RS03305	COG2009	succinate dehydrogenase
AFLV_RS03310	COG1053	succinate dehydrogenase
AFLV_RS03315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFLV_RS03320	COG0824	Thioesterase
AFLV_RS03325	COG2197	response regulator
AFLV_RS03330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFLV_RS03335	COG5401	PFAM Sporulation and spore germination
AFLV_RS03340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFLV_RS03345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFLV_RS03350	COG0622	Phosphoesterase
AFLV_RS03360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AFLV_RS03365	COG0028	Belongs to the TPP enzyme family
AFLV_RS03370	COG0440	acetolactate synthase activity
AFLV_RS03375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFLV_RS03380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFLV_RS03385	COG0473	3-isopropylmalate dehydrogenase activity
AFLV_RS03390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFLV_RS03395	COG0066	3-isopropylmalate dehydratase activity
AFLV_RS03405	COG0544	peptidyl-prolyl cis-trans isomerase activity
AFLV_RS03410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFLV_RS03415	COG1067	ATP-dependent peptidase activity
AFLV_RS03415	COG0470	DNA polymerase III
AFLV_RS03425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AFLV_RS03440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFLV_RS03445	COG0181	hydroxymethylbilane synthase activity
AFLV_RS03450	COG1587	Uroporphyrinogen-III synthase
AFLV_RS03455	COG0113	porphobilinogen synthase activity
AFLV_RS03460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFLV_RS03465	COG1388	LysM domain
AFLV_RS03465	COG1388	LysM domain
AFLV_RS03470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFLV_RS03480	COG0525	valine-tRNA ligase activity
AFLV_RS03485	COG0285	dihydrofolate synthase activity
AFLV_RS03530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFLV_RS03540	COG1459	type II secretion system
AFLV_RS03545	COG4969	Belongs to the N-Me-Phe pilin family
AFLV_RS03550	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AFLV_RS03595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFLV_RS03690	COG1595	DNA-templated transcription, initiation
AFLV_RS03810	COG1876	peptidase activity
AFLV_RS03840	COG2003	Belongs to the UPF0758 family
AFLV_RS03845	COG1077	Cell shape determining protein MreB Mrl
AFLV_RS03850	COG1792	Involved in formation and maintenance of cell shape
AFLV_RS03860	COG0850	regulation of cytokinetic process
AFLV_RS03865	COG2894	cell division
AFLV_RS03870	COG0739	heme binding
AFLV_RS03875	COG1994	Peptidase M50
AFLV_RS03880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFLV_RS03885	COG2868	ribosomal protein
AFLV_RS03890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFLV_RS03895	COG3290	protein histidine kinase activity
AFLV_RS03900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFLV_RS03905	COG4492	Belongs to the UPF0735 family
AFLV_RS03910	COG0077	Prephenate dehydratase
AFLV_RS03915	COG1827	regulation of RNA biosynthetic process
AFLV_RS03920	COG1104	cysteine desulfurase activity
AFLV_RS03925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFLV_RS03930	COG0157	Belongs to the NadC ModD family
AFLV_RS03935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFLV_RS03940	COG1388	LysM domain
AFLV_RS03945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFLV_RS03955	COG0217	transcriptional regulatory protein
AFLV_RS03965	COG0632	four-way junction helicase activity
AFLV_RS03970	COG2255	four-way junction helicase activity
AFLV_RS03985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFLV_RS03990	COG0343	queuine tRNA-ribosyltransferase activity
AFLV_RS03995	COG1862	Preprotein translocase
AFLV_RS04005	COG2323	membrane
AFLV_RS04010	COG2244	polysaccharide biosynthetic process
AFLV_RS04020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFLV_RS04020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFLV_RS04025	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFLV_RS04030	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AFLV_RS04030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AFLV_RS04035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AFLV_RS04040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFLV_RS04045	COG1490	D-aminoacyl-tRNA deacylase activity
AFLV_RS04055	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFLV_RS04060	COG0124	histidyl-tRNA synthetase
AFLV_RS04065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFLV_RS04070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AFLV_RS04075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AFLV_RS04080	COG1309	transcriptional regulator
AFLV_RS04085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AFLV_RS04090	COG1959	2 iron, 2 sulfur cluster binding
AFLV_RS04095	COG1104	cysteine desulfurase activity
AFLV_RS04100	COG0482	sulfurtransferase activity
AFLV_RS04110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AFLV_RS04120	COG0628	permease
AFLV_RS04125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFLV_RS04130	COG4472	Bacterial protein of unknown function (DUF965)
AFLV_RS04135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFLV_RS04140	COG3906	Belongs to the UPF0473 family
AFLV_RS04145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AFLV_RS04150	COG4122	O-methyltransferase activity
AFLV_RS04155	COG0826	peptidase U32
AFLV_RS04160	COG0826	peptidase U32
AFLV_RS04165	COG0572	uridine kinase
AFLV_RS04170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFLV_RS04175	COG0768	penicillin binding
AFLV_RS04195	COG2226	methyltransferase
AFLV_RS04200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AFLV_RS04205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFLV_RS04210	COG0626	cystathionine gamma-synthase activity
AFLV_RS04260	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AFLV_RS04300	COG1396	sequence-specific DNA binding
AFLV_RS04415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFLV_RS04425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFLV_RS04430	COG1360	Flagellar Motor Protein
AFLV_RS04435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFLV_RS04440	COG1183	phosphatidylcholine synthase activity
AFLV_RS04445	COG0688	phosphatidylethanolamine metabolic process
AFLV_RS04455	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AFLV_RS04460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AFLV_RS04465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFLV_RS04470	COG1534	Rna-binding protein
AFLV_RS04475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFLV_RS04480	COG1713	HD superfamily hydrolase involved in NAD metabolism
AFLV_RS04485	COG0799	negative regulation of ribosome biogenesis
AFLV_RS04490	COG2226	methyltransferase
AFLV_RS04495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFLV_RS04500	COG1596	polysaccharide export
AFLV_RS04500	COG1555	photosystem II stabilization
AFLV_RS04505	COG2131	deaminase
AFLV_RS04510	COG2333	competence protein COMEC
AFLV_RS04510	COG0658	competence protein
AFLV_RS04520	COG1466	dna polymerase III delta subunit
AFLV_RS04525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFLV_RS04530	COG0268	Binds directly to 16S ribosomal RNA
AFLV_RS04535	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AFLV_RS04540	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFLV_RS04550	COG0481	GTPase activity
AFLV_RS04555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFLV_RS04560	COG1420	regulation of RNA biosynthetic process
AFLV_RS04565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AFLV_RS04570	COG0443	Heat shock 70 kDa protein
AFLV_RS04575	COG0484	heat shock protein binding
AFLV_RS04580	COG2264	protein methyltransferase activity
AFLV_RS04585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AFLV_RS04590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFLV_RS04595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AFLV_RS04600	COG1610	YqeY-like protein
AFLV_RS04605	COG1030	water channel activity
AFLV_RS04610	COG4864	UPF0365 protein
AFLV_RS04630	COG1702	phosphate starvation-inducible protein PhoH
AFLV_RS04635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFLV_RS04640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AFLV_RS04645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFLV_RS04650	COG1381	Involved in DNA repair and RecF pathway recombination
AFLV_RS04655	COG0517	IMP dehydrogenase activity
AFLV_RS04660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AFLV_RS04670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFLV_RS04680	COG2010	Cytochrome c
AFLV_RS04685	COG2384	SAM-dependent methyltransferase
AFLV_RS04690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AFLV_RS04695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFLV_RS04710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AFLV_RS04720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AFLV_RS04725	COG1121	(ABC) transporter
AFLV_RS04730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFLV_RS04735	COG0735	belongs to the Fur family
AFLV_RS04740	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AFLV_RS04745	COG4709	membrane
AFLV_RS04750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFLV_RS04755	COG1388	LysM domain
AFLV_RS04760	COG0840	transmembrane signaling receptor activity
AFLV_RS04765	COG5521	maltodextrose utilization protein MalA
AFLV_RS04780	COG0477	Major facilitator Superfamily
AFLV_RS04785	COG0768	penicillin binding
AFLV_RS04790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AFLV_RS04795	COG0573	inorganic phosphate transmembrane transporter activity
AFLV_RS04800	COG0581	inorganic phosphate transmembrane transporter activity
AFLV_RS04805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AFLV_RS04810	COG0704	Plays a role in the regulation of phosphate uptake
AFLV_RS04825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AFLV_RS04830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFLV_RS04835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AFLV_RS04840	COG0039	L-malate dehydrogenase activity
AFLV_RS04850	COG0457	Tetratricopeptide repeat
AFLV_RS04850	COG0705	Rhomboid family
AFLV_RS04860	COG0697	spore germination
AFLV_RS04865	COG4483	Protein conserved in bacteria
AFLV_RS04870	COG1940	carbohydrate kinase activity
AFLV_RS04875	COG1368	sulfuric ester hydrolase activity
AFLV_RS04890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFLV_RS04910	COG1393	Belongs to the ArsC family
AFLV_RS04915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AFLV_RS04920	COG1459	type II secretion system
AFLV_RS04925	COG4537	Required for transformation and DNA binding
AFLV_RS04930	COG4537	Required for transformation and DNA binding
AFLV_RS04965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFLV_RS04970	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFLV_RS04975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFLV_RS04980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFLV_RS04985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFLV_RS04990	COG0095	Lipoate-protein ligase
AFLV_RS04995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFLV_RS05000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFLV_RS05010	COG1321	iron dependent repressor
AFLV_RS05015	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFLV_RS05025	COG3872	metal-dependent enzyme
AFLV_RS05035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFLV_RS05040	COG0006	proline dipeptidase activity
AFLV_RS05045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFLV_RS05065	COG3854	ATPases associated with a variety of cellular activities
AFLV_RS05105	COG0511	ligase activity, forming carbon-carbon bonds
AFLV_RS05110	COG0439	Biotin carboxylase
AFLV_RS05115	COG1302	Protein conserved in bacteria
AFLV_RS05120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFLV_RS05125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFLV_RS05130	COG1570	exodeoxyribonuclease VII activity
AFLV_RS05135	COG1722	exodeoxyribonuclease VII activity
AFLV_RS05145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AFLV_RS05150	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AFLV_RS05160	COG0497	DNA recombination
AFLV_RS05165	COG0750	zinc metalloprotease
AFLV_RS05175	COG0584	glycerophosphoryl diester phosphodiesterase
AFLV_RS05185	COG3290	protein histidine kinase activity
AFLV_RS05185	COG3829	transcription factor binding
AFLV_RS05190	COG0280	phosphate acetyltransferase
AFLV_RS05200	COG3426	butyrate kinase activity
AFLV_RS05205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFLV_RS05210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AFLV_RS05215	COG0022	dehydrogenase e1 component
AFLV_RS05220	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFLV_RS05225	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFLV_RS05230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFLV_RS05230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFLV_RS05240	COG4129	membrane
AFLV_RS05245	COG1376	ErfK ybiS ycfS ynhG family protein
AFLV_RS05250	COG0346	lactoylglutathione lyase activity
AFLV_RS05255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFLV_RS05265	COG2195	Cleaves the N-terminal amino acid of tripeptides
AFLV_RS05275	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AFLV_RS05280	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AFLV_RS05285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AFLV_RS05290	COG1234	tRNA 3'-trailer cleavage
AFLV_RS05300	COG1902	pentaerythritol trinitrate reductase activity
AFLV_RS05305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFLV_RS05310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFLV_RS05315	COG0300	oxidoreductase activity
AFLV_RS05320	COG4918	Iron-sulphur cluster biosynthesis
AFLV_RS05340	COG0667	Aldo Keto reductase
AFLV_RS05345	COG0494	nUDIX hydrolase
AFLV_RS05350	COG1300	Membrane
AFLV_RS05360	COG0735	belongs to the Fur family
AFLV_RS05370	COG4974	Belongs to the 'phage' integrase family
AFLV_RS05390	COG1686	Belongs to the peptidase S11 family
AFLV_RS05400	COG2172	sigma factor antagonist activity
AFLV_RS05425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFLV_RS05440	COG0697	spore germination
AFLV_RS05445	COG0019	diaminopimelate decarboxylase activity
AFLV_RS05450	COG4086	secreted protein
AFLV_RS05455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AFLV_RS05460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFLV_RS05460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AFLV_RS05465	COG0307	riboflavin synthase, alpha
AFLV_RS05470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFLV_RS05470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFLV_RS05475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AFLV_RS05485	COG1547	Domain of unknown function (DUF309)
AFLV_RS05490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AFLV_RS05495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFLV_RS05505	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AFLV_RS05515	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFLV_RS05545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AFLV_RS05550	COG1686	Belongs to the peptidase S11 family
AFLV_RS05555	COG2715	membrane protein required for spore maturation
AFLV_RS05560	COG0700	Nucleoside recognition
AFLV_RS05565	COG1187	pseudouridine synthase activity
AFLV_RS05570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFLV_RS05575	COG1333	cytochrome c biogenesis protein
AFLV_RS05580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFLV_RS05585	COG0745	RESPONSE REGULATOR receiver
AFLV_RS05590	COG5002	protein histidine kinase activity
AFLV_RS05595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFLV_RS05600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFLV_RS05605	COG1120	ATPase activity
AFLV_RS05610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AFLV_RS05625	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AFLV_RS05640	COG2096	Adenosyltransferase
AFLV_RS05655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AFLV_RS05660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFLV_RS05675	COG4955	Helix-turn-helix domain
AFLV_RS05680	COG0514	ATP-dependent DNA helicase (RecQ)
AFLV_RS05685	COG1266	CAAX protease self-immunity
AFLV_RS05705	COG1408	metallophosphoesterase
AFLV_RS05710	COG0789	Transcriptional regulator
AFLV_RS05715	COG4862	establishment of competence for transformation
AFLV_RS05720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFLV_RS05725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AFLV_RS05730	COG0492	ferredoxin-NADP+ reductase activity
AFLV_RS05735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AFLV_RS05740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFLV_RS05745	COG2959	enzyme of heme biosynthesis
AFLV_RS05750	COG3773	Cell wall hydrolase
AFLV_RS05750	COG3409	Peptidoglycan-binding domain 1 protein
AFLV_RS05755	COG2339	peptidase activity
AFLV_RS05760	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AFLV_RS05770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AFLV_RS05780	COG0539	negative regulation of cytoplasmic translation
AFLV_RS05785	COG1304	FMN binding
AFLV_RS05805	COG1160	GTP binding
AFLV_RS05810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AFLV_RS05825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFLV_RS05835	COG0302	gtp cyclohydrolase
AFLV_RS05845	COG0142	geranyltranstransferase activity
AFLV_RS05850	COG2226	methyltransferase
AFLV_RS05860	COG0105	UTP biosynthetic process
AFLV_RS05865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AFLV_RS05870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFLV_RS05875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AFLV_RS05880	COG4401	Chorismate mutase type I
AFLV_RS05890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFLV_RS05895	COG0134	indole-3-glycerol-phosphate synthase activity
AFLV_RS05900	COG0135	phosphoribosylanthranilate isomerase activity
AFLV_RS05905	COG0133	tryptophan synthase activity
AFLV_RS05910	COG0159	tryptophan synthase activity
AFLV_RS05915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFLV_RS05920	COG0287	Prephenate dehydrogenase
AFLV_RS05925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFLV_RS05930	COG0457	Tetratricopeptide repeat
AFLV_RS05935	COG5582	Belongs to the UPF0302 family
AFLV_RS05960	COG4347	Protein of unknown function (DUF1405)
AFLV_RS05970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AFLV_RS05975	COG1694	Mazg nucleotide pyrophosphohydrolase
AFLV_RS05980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AFLV_RS05985	COG1803	Methylglyoxal synthase
AFLV_RS05990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFLV_RS05995	COG0438	transferase activity, transferring glycosyl groups
AFLV_RS06000	COG0617	tRNA 3'-terminal CCA addition
AFLV_RS06010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFLV_RS06015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AFLV_RS06020	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AFLV_RS06025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFLV_RS06025	COG1199	ATP-dependent helicase activity
AFLV_RS06045	COG0017	Asparaginyl-tRNA synthetase
AFLV_RS06050	COG3935	DnaD domain protein
AFLV_RS06055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFLV_RS06065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFLV_RS06065	COG4499	WXG100 protein secretion system (Wss), protein YukC
AFLV_RS06070	COG3331	DNA recombination
AFLV_RS06075	COG0659	secondary active sulfate transmembrane transporter activity
AFLV_RS06110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AFLV_RS06115	COG2217	Heavy metal translocating P-type atpase
AFLV_RS06150	COG1929	Belongs to the glycerate kinase type-1 family
AFLV_RS06160	COG1120	ATPase activity
AFLV_RS06165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFLV_RS06170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFLV_RS06175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFLV_RS06180	COG0156	8-amino-7-oxononanoate synthase activity
AFLV_RS06185	COG0596	Alpha beta hydrolase
AFLV_RS06190	COG4106	trans-aconitate 2-methyltransferase activity
AFLV_RS06195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AFLV_RS06200	COG0475	glutathione-regulated potassium exporter activity
AFLV_RS06200	COG0569	domain protein
AFLV_RS06210	COG1061	Type III restriction enzyme res subunit
AFLV_RS06235	COG0210	DNA helicase
AFLV_RS06255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFLV_RS06270	COG2207	Transcriptional regulator
AFLV_RS06275	COG4948	Mandelate Racemase Muconate Lactonizing
AFLV_RS06280	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS06285	COG1027	Aspartate ammonia-lyase
AFLV_RS06290	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS06295	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AFLV_RS06305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AFLV_RS06365	COG2195	Cleaves the N-terminal amino acid of tripeptides
AFLV_RS06375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFLV_RS06380	COG1968	undecaprenyl-diphosphatase activity
AFLV_RS06385	COG0110	maltose O-acetyltransferase activity
AFLV_RS06390	COG0535	radical SAM domain protein
AFLV_RS06400	COG0697	spore germination
AFLV_RS06410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AFLV_RS06415	COG0656	L-ascorbic acid biosynthetic process
AFLV_RS06435	COG1621	beta-fructofuranosidase activity
AFLV_RS06485	COG1937	Protein conserved in bacteria
AFLV_RS06490	COG2217	Heavy metal translocating P-type atpase
AFLV_RS06520	COG2608	mercury ion transmembrane transporter activity
AFLV_RS06525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFLV_RS06535	COG4152	abc transporter atp-binding protein
AFLV_RS06550	COG0367	asparagine synthase
AFLV_RS06565	COG0415	Belongs to the DNA photolyase family
AFLV_RS06570	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS06585	COG2246	polysaccharide biosynthetic process
AFLV_RS06595	COG0583	DNA-binding transcription factor activity
AFLV_RS06600	COG0069	glutamate synthase activity
AFLV_RS06600	COG0067	glutamate synthase
AFLV_RS06600	COG0070	glutamate synthase
AFLV_RS06605	COG0493	'glutamate synthase
AFLV_RS06615	COG0129	dihydroxy-acid dehydratase activity
AFLV_RS06625	COG1960	acyl-CoA dehydrogenase activity
AFLV_RS06635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AFLV_RS06645	COG0531	amino acid
AFLV_RS06650	COG0028	Belongs to the TPP enzyme family
AFLV_RS06655	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS06670	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFLV_RS06675	COG0644	oxidoreductase
AFLV_RS06715	COG2267	carboxylic ester hydrolase activity
AFLV_RS06750	COG3335	DDE superfamily endonuclease
AFLV_RS06755	COG2211	Major facilitator Superfamily
AFLV_RS06770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AFLV_RS06775	COG1028	Short-chain dehydrogenase reductase Sdr
AFLV_RS06780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFLV_RS06785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFLV_RS06790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFLV_RS06795	COG1120	ATPase activity
AFLV_RS06805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFLV_RS06810	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFLV_RS06820	COG4152	abc transporter atp-binding protein
AFLV_RS06825	COG1668	transmembrane transport
AFLV_RS06840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFLV_RS06850	COG0318	PFAM AMP-dependent synthetase and ligase
AFLV_RS06855	COG1960	acyl-CoA dehydrogenase activity
AFLV_RS06860	COG1272	protein, Hemolysin III
AFLV_RS06880	COG3314	Sporulation integral membrane protein YlbJ
AFLV_RS06890	COG0531	amino acid
AFLV_RS06895	COG0803	Belongs to the bacterial solute-binding protein 9 family
AFLV_RS06900	COG1121	(ABC) transporter
AFLV_RS06910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AFLV_RS06930	COG3853	Toxic anion resistance protein (TelA)
AFLV_RS06950	COG2814	Major facilitator Superfamily
AFLV_RS06955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AFLV_RS06960	COG0840	transmembrane signaling receptor activity
AFLV_RS06960	COG3290	protein histidine kinase activity
AFLV_RS06975	COG2972	Histidine kinase
AFLV_RS06980	COG3279	Response regulator of the LytR AlgR family
AFLV_RS06985	COG4213	ABC transporter substrate-binding protein
AFLV_RS06990	COG1129	ABC transporter
AFLV_RS06995	COG4214	carbohydrate transport
AFLV_RS07000	COG4948	Mandelate Racemase Muconate Lactonizing
AFLV_RS07010	COG4844	belongs to the
AFLV_RS07035	COG0456	acetyltransferase
AFLV_RS07040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFLV_RS07040	COG3153	acetyltransferase
AFLV_RS07045	COG0386	Belongs to the glutathione peroxidase family
AFLV_RS07050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFLV_RS07055	COG0438	transferase activity, transferring glycosyl groups
AFLV_RS07065	COG1132	(ABC) transporter
AFLV_RS07070	COG1132	(ABC) transporter
AFLV_RS07090	COG0004	ammonium transporteR
AFLV_RS07100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFLV_RS07100	COG1199	ATP-dependent helicase activity
AFLV_RS07105	COG0640	Transcriptional regulator
AFLV_RS07115	COG5001	Diguanylate cyclase
AFLV_RS07115	COG3300	MHYT domain
AFLV_RS07135	COG1131	(ABC) transporter
AFLV_RS07145	COG1525	nuclease
AFLV_RS07150	COG1151	hydroxylamine reductase activity
AFLV_RS07155	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AFLV_RS07160	COG0352	thiamine-phosphate diphosphorylase activity
AFLV_RS07165	COG1024	Enoyl-CoA hydratase
AFLV_RS07170	COG2208	phosphoserine phosphatase activity
AFLV_RS07190	COG0840	transmembrane signaling receptor activity
AFLV_RS07210	COG0116	Belongs to the methyltransferase superfamily
AFLV_RS07215	COG1199	ATP-dependent helicase activity
AFLV_RS07220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AFLV_RS07225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFLV_RS07230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFLV_RS07260	COG3424	synthase
AFLV_RS07265	COG1755	Isoprenylcysteine carboxyl methyltransferase
AFLV_RS07270	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AFLV_RS07280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFLV_RS07295	COG0824	Thioesterase
AFLV_RS07300	COG4841	protein insertion into membrane
AFLV_RS07320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AFLV_RS07330	COG4326	sporulation control protein
AFLV_RS07345	COG0813	purine-nucleoside phosphorylase activity
AFLV_RS07350	COG1876	peptidase activity
AFLV_RS07360	COG2056	Na+-H+ antiporter family
AFLV_RS07365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AFLV_RS07370	COG2962	Rard protein
AFLV_RS07375	COG0534	Mate efflux family protein
AFLV_RS07380	COG1115	amino acid carrier protein
AFLV_RS07385	COG3852	Histidine kinase
AFLV_RS07395	COG3546	catalase activity
AFLV_RS07400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFLV_RS07420	COG1725	Transcriptional regulator
AFLV_RS07425	COG1131	(ABC) transporter
AFLV_RS07435	COG0826	peptidase U32
AFLV_RS07445	COG1278	Cold shock
AFLV_RS07455	COG2755	lipolytic protein G-D-S-L family
AFLV_RS07460	COG1131	(ABC) transporter
AFLV_RS07465	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AFLV_RS07470	COG0494	nUDIX hydrolase
AFLV_RS07485	COG3341	Caulimovirus viroplasmin
AFLV_RS07485	COG0328	RNA-DNA hybrid ribonuclease activity
AFLV_RS07495	COG0640	Transcriptional regulator
AFLV_RS07500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFLV_RS07505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AFLV_RS07510	COG0583	DNA-binding transcription factor activity
AFLV_RS07515	COG0697	spore germination
AFLV_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
AFLV_RS07530	COG1119	ATPase activity
AFLV_RS07560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFLV_RS07560	COG0551	DNA topoisomerase type I activity
AFLV_RS07565	COG3335	DDE superfamily endonuclease
AFLV_RS07575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFLV_RS07575	COG0551	DNA topoisomerase type I activity
AFLV_RS07585	COG1115	amino acid carrier protein
AFLV_RS07590	COG4548	von Willebrand factor, type A
AFLV_RS07595	COG0714	Associated with various cellular activities
AFLV_RS07600	COG1937	Protein conserved in bacteria
AFLV_RS07610	COG0788	formyltetrahydrofolate deformylase activity
AFLV_RS07615	COG2116	formate transmembrane transporter activity
AFLV_RS07620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFLV_RS07625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFLV_RS07630	COG2188	Transcriptional regulator
AFLV_RS07635	COG0366	Alpha amylase catalytic
AFLV_RS07640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFLV_RS07640	COG1263	PTS System
AFLV_RS07650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFLV_RS07655	COG0187	DNA topoisomerase II activity
AFLV_RS07660	COG1832	CoA-binding protein
AFLV_RS07665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AFLV_RS07670	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AFLV_RS07670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFLV_RS07680	COG2755	lipolytic protein G-D-S-L family
AFLV_RS07685	COG1999	signal sequence binding
AFLV_RS07700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AFLV_RS07705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AFLV_RS07710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AFLV_RS07715	COG0805	protein transport
AFLV_RS07720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFLV_RS07730	COG1301	dicarboxylic acid transport
AFLV_RS07735	COG2521	methyltransferase
AFLV_RS07735	COG2136	Putative SAM-dependent methyltransferase
AFLV_RS07745	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AFLV_RS07750	COG2814	Major facilitator Superfamily
AFLV_RS07765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AFLV_RS07770	COG1988	membrane-bound metal-dependent
AFLV_RS07785	COG1587	Uroporphyrinogen-III synthase
AFLV_RS07790	COG5002	protein histidine kinase activity
AFLV_RS07795	COG0716	FMN binding
AFLV_RS07800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFLV_RS07800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFLV_RS07800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AFLV_RS07805	COG1105	Belongs to the carbohydrate kinase PfkB family
AFLV_RS07810	COG1349	DNA-binding transcription factor activity
AFLV_RS07825	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFLV_RS07830	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AFLV_RS07835	COG0432	Pfam Uncharacterised protein family UPF0047
AFLV_RS07860	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AFLV_RS07870	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AFLV_RS07880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFLV_RS07910	COG4846	Membrane protein involved in cytochrome C biogenesis
AFLV_RS07915	COG2201	protein-glutamate methylesterase activity
AFLV_RS07920	COG0785	Cytochrome C biogenesis protein
AFLV_RS07925	COG3763	UPF0154 protein
AFLV_RS07935	COG4224	UPF0291 protein
AFLV_RS07940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AFLV_RS07945	COG1388	LysM domain
AFLV_RS07950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AFLV_RS07955	COG0174	glutamine synthetase
AFLV_RS07960	COG0789	Transcriptional regulator
AFLV_RS07965	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AFLV_RS07970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFLV_RS07975	COG2860	membrane
AFLV_RS07980	COG0183	Belongs to the thiolase family
AFLV_RS07985	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFLV_RS07990	COG0318	PFAM AMP-dependent synthetase and ligase
AFLV_RS07995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFLV_RS08000	COG1960	acyl-CoA dehydrogenase activity
AFLV_RS08010	COG0464	growth
AFLV_RS08015	COG1923	regulation of RNA biosynthetic process
AFLV_RS08020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AFLV_RS08025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AFLV_RS08030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AFLV_RS08040	COG4550	Control of competence regulator ComK, YlbF/YmcA
AFLV_RS08045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AFLV_RS08050	COG1013	pyruvate-flavodoxin oxidoreductase activity
AFLV_RS08055	COG0674	pyruvate-flavodoxin oxidoreductase activity
AFLV_RS08055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AFLV_RS08065	COG2359	stage V sporulation protein S
AFLV_RS08070	COG1692	metallophosphoesterase
AFLV_RS08075	COG1418	mRNA catabolic process
AFLV_RS08085	COG1058	Belongs to the CinA family
AFLV_RS08085	COG1546	Belongs to the CinA family
AFLV_RS08090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFLV_RS08095	COG1426	Protein conserved in bacteria
AFLV_RS08110	COG0300	oxidoreductase activity
AFLV_RS08115	COG0612	Peptidase, M16
AFLV_RS08120	COG0612	Peptidase, M16
AFLV_RS08125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFLV_RS08130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFLV_RS08135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFLV_RS08150	COG0789	Transcriptional regulator
AFLV_RS08160	COG5609	conserved protein (DUF2294)
AFLV_RS08175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFLV_RS08185	COG0371	Dehydrogenase
AFLV_RS08205	COG1742	UPF0060 membrane protein
AFLV_RS08210	COG3852	Histidine kinase
AFLV_RS08235	COG0246	Mannitol dehydrogenase
AFLV_RS08245	COG3711	transcriptional antiterminator
AFLV_RS08260	COG2340	Cysteine-rich secretory protein family
AFLV_RS08270	COG1414	Transcriptional regulator
AFLV_RS08275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AFLV_RS08290	COG1131	(ABC) transporter
AFLV_RS08305	COG3773	Cell wall hydrolase
AFLV_RS08315	COG1846	Transcriptional regulator
AFLV_RS08320	COG2259	Doxx family
AFLV_RS08325	COG1741	Belongs to the pirin family
AFLV_RS08330	COG2223	nitrite transmembrane transporter activity
AFLV_RS08340	COG4989	oxidoreductase activity
AFLV_RS08345	COG4377	Putative membrane peptidase family (DUF2324)
AFLV_RS08350	COG5658	integral membrane protein
AFLV_RS08355	COG0640	Transcriptional regulator
AFLV_RS08360	COG0393	Putative heavy-metal-binding
AFLV_RS08365	COG2076	Multidrug Resistance protein
AFLV_RS08370	COG0584	glycerophosphoryl diester phosphodiesterase
AFLV_RS08385	COG1175	transmembrane transport
AFLV_RS08395	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AFLV_RS08400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AFLV_RS08405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AFLV_RS08410	COG0583	DNA-binding transcription factor activity
AFLV_RS08430	COG3428	Bacterial PH domain
AFLV_RS08435	COG3402	PFAM membrane-flanked domain
AFLV_RS08440	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS08450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFLV_RS08455	COG3739	integral membrane protein
AFLV_RS08460	COG3655	Transcriptional regulator
AFLV_RS08475	COG3654	unkown
AFLV_RS08490	COG5646	InterPro IPR014922
AFLV_RS08495	COG1192	Involved in chromosome partitioning
AFLV_RS08505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFLV_RS08530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFLV_RS08540	COG1413	lyase activity
AFLV_RS08550	COG2816	NAD+ diphosphatase activity
AFLV_RS08590	COG2801	Transposase and inactivated derivatives
AFLV_RS08635	COG3335	DDE superfamily endonuclease
AFLV_RS08660	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFLV_RS08665	COG0579	oxidoreductase
AFLV_RS08695	COG0659	secondary active sulfate transmembrane transporter activity
AFLV_RS08700	COG0589	response to stress
AFLV_RS08710	COG2610	gluconate transmembrane transporter activity
AFLV_RS08715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFLV_RS08760	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS08765	COG1079	Belongs to the binding-protein-dependent transport system permease family
AFLV_RS08770	COG4603	Belongs to the binding-protein-dependent transport system permease family
AFLV_RS08775	COG3845	ABC transporter
AFLV_RS08780	COG1744	ABC transporter substrate-binding protein PnrA-like
AFLV_RS08785	COG2188	Transcriptional regulator
AFLV_RS08790	COG1674	ftsk spoiiie
AFLV_RS08790	COG4980	gas vesicle protein
AFLV_RS08800	COG0740	serine-type endopeptidase activity
AFLV_RS08805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFLV_RS08815	COG0527	aspartate kinase activity
AFLV_RS08820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AFLV_RS08825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFLV_RS08830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFLV_RS08835	COG1873	PFAM PRC-barrel domain
AFLV_RS08840	COG0612	Peptidase, M16
AFLV_RS08845	COG0726	polysaccharide deacetylase
AFLV_RS08850	COG1185	polyribonucleotide nucleotidyltransferase activity
AFLV_RS08855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFLV_RS08860	COG0196	riboflavin kinase activity
AFLV_RS08865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFLV_RS08870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFLV_RS08875	COG1550	Protein conserved in bacteria
AFLV_RS08880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFLV_RS08885	COG1358	cellular component organization or biogenesis
AFLV_RS08890	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AFLV_RS08895	COG0195	Participates in both transcription termination and antitermination
AFLV_RS08900	COG0779	Required for maturation of 30S ribosomal subunits
AFLV_RS08905	COG2176	DNA-directed DNA polymerase activity
AFLV_RS08910	COG0442	prolyl-tRNA aminoacylation
AFLV_RS08915	COG0750	zinc metalloprotease
AFLV_RS08920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFLV_RS08925	COG4589	Belongs to the CDS family
AFLV_RS08930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFLV_RS08935	COG0233	cytoplasmic translational termination
AFLV_RS08940	COG0528	UMP kinase activity
AFLV_RS08945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFLV_RS08950	COG0052	Belongs to the universal ribosomal protein uS2 family
AFLV_RS08965	COG1191	sigma factor activity
AFLV_RS08975	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AFLV_RS08980	COG1776	CheC inhibitor of MCP methylation
AFLV_RS08985	COG0835	chemotaxis
AFLV_RS08990	COG2198	Histidine kinase
AFLV_RS08990	COG0643	Histidine kinase
AFLV_RS08995	COG2201	protein-glutamate methylesterase activity
AFLV_RS09000	COG0455	bacterial-type flagellum organization
AFLV_RS09005	COG1419	protein localization to endoplasmic reticulum
AFLV_RS09010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFLV_RS09015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFLV_RS09020	COG1684	flagellar biosynthetic protein fliR
AFLV_RS09025	COG1987	bacterial-type flagellum assembly
AFLV_RS09030	COG1338	Plays a role in the flagellum-specific transport system
AFLV_RS09035	COG3190	flagellar
AFLV_RS09040	COG2201	protein-glutamate methylesterase activity
AFLV_RS09045	COG1776	CheC inhibitor of MCP methylation
AFLV_RS09045	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFLV_RS09050	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFLV_RS09055	COG1580	Controls the rotational direction of flagella during chemotaxis
AFLV_RS09060	COG1582	Flagellar protein (FlbD)
AFLV_RS09065	COG4786	Flagellar basal body rod
AFLV_RS09075	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AFLV_RS09080	COG3144	bacterial-type flagellum assembly
AFLV_RS09090	COG2882	bacterial-type flagellum organization
AFLV_RS09095	COG1157	protein secretion by the type III secretion system
AFLV_RS09100	COG1317	bacterial-type flagellum organization
AFLV_RS09105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AFLV_RS09110	COG1766	The M ring may be actively involved in energy transduction
AFLV_RS09115	COG1677	Flagellar hook-basal body complex protein FliE
AFLV_RS09120	COG1558	bacterial-type flagellum-dependent cell motility
AFLV_RS09125	COG1815	bacterial-type flagellum-dependent cell motility
AFLV_RS09130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AFLV_RS09135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AFLV_RS09140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AFLV_RS09145	COG4974	Belongs to the 'phage' integrase family
AFLV_RS09150	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AFLV_RS09155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFLV_RS09160	COG0758	DNA mediated transformation
AFLV_RS09165	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFLV_RS09170	COG0045	succinate-CoA ligase (ADP-forming) activity
AFLV_RS09175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFLV_RS09185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFLV_RS09190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AFLV_RS09200	COG0335	large ribosomal subunit rRNA binding
AFLV_RS09205	COG0336	Belongs to the RNA methyltransferase TrmD family
AFLV_RS09210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFLV_RS09220	COG1837	Belongs to the UPF0109 family
AFLV_RS09225	COG0228	four-way junction DNA binding
AFLV_RS09230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AFLV_RS09235	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AFLV_RS09240	COG0552	protein localization to endoplasmic reticulum
AFLV_RS09245	COG1196	nuclear chromosome segregation
AFLV_RS09255	COG0571	ribonuclease III activity
AFLV_RS09260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFLV_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
AFLV_RS09270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFLV_RS09275	COG0416	fatty acid biosynthetic process
AFLV_RS09280	COG1349	DNA-binding transcription factor activity
AFLV_RS09285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AFLV_RS09290	COG1760	l-serine dehydratase
AFLV_RS09295	COG1760	l-serine dehydratase
AFLV_RS09300	COG1461	Dihydroxyacetone kinase
AFLV_RS09305	COG1302	Protein conserved in bacteria
AFLV_RS09310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFLV_RS09320	COG1564	THIamine pyrophosphokinase
AFLV_RS09325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFLV_RS09330	COG1162	GTPase activity
AFLV_RS09335	COG0515	serine threonine protein kinase
AFLV_RS09335	COG2815	serine threonine protein kinase
AFLV_RS09340	COG0631	protein serine/threonine phosphatase activity
AFLV_RS09345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFLV_RS09350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AFLV_RS09350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AFLV_RS09355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFLV_RS09360	COG0242	peptide deformylase activity
AFLV_RS09365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AFLV_RS09370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AFLV_RS09375	COG1758	RNA polymerase activity
AFLV_RS09380	COG0194	GDP metabolic process
AFLV_RS09385	COG1561	YicC-like family, N-terminal region
AFLV_RS09390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AFLV_RS09395	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AFLV_RS09410	COG0284	orotidine-5'-phosphate decarboxylase activity
AFLV_RS09415	COG0167	dihydroorotate dehydrogenase activity
AFLV_RS09420	COG0543	2 iron, 2 sulfur cluster binding
AFLV_RS09435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFLV_RS09440	COG0540	Belongs to the ATCase OTCase family
AFLV_RS09450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFLV_RS09455	COG0564	pseudouridine synthase activity
AFLV_RS09460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFLV_RS09470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFLV_RS09475	COG3599	regulation of cell shape
AFLV_RS09480	COG2302	S4 RNA-binding domain
AFLV_RS09485	COG0762	integral membrane protein
AFLV_RS09490	COG1799	cell septum assembly
AFLV_RS09495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AFLV_RS09505	COG1873	PFAM PRC-barrel domain
AFLV_RS09510	COG1191	sigma factor activity
AFLV_RS09515	COG1191	sigma factor activity
AFLV_RS09525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFLV_RS09530	COG0849	cell division
AFLV_RS09535	COG3856	small basic protein
AFLV_RS09540	COG3879	Bacterial protein of unknown function (DUF881)
AFLV_RS09545	COG3879	Bacterial protein of unknown function (DUF881)
AFLV_RS09550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AFLV_RS09555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFLV_RS09560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFLV_RS09565	COG0772	Belongs to the SEDS family
AFLV_RS09570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFLV_RS09575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFLV_RS09580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFLV_RS09585	COG0768	penicillin binding
AFLV_RS09590	COG0768	penicillin binding
AFLV_RS09595	COG4839	cell division protein FtsL
AFLV_RS09600	COG0275	rRNA processing
AFLV_RS09605	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AFLV_RS09615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AFLV_RS09625	COG1024	Enoyl-CoA hydratase
AFLV_RS09630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AFLV_RS09635	COG1399	metal-binding, possibly nucleic acid-binding protein
AFLV_RS09640	COG1323	Belongs to the UPF0348 family
AFLV_RS09645	COG3480	Lon protease (S16) C-terminal proteolytic domain
AFLV_RS09650	COG1752	Esterase of the alpha-beta hydrolase superfamily
AFLV_RS09655	COG3314	Sporulation integral membrane protein YlbJ
AFLV_RS09660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFLV_RS09665	COG0742	ribosomal rna small subunit methyltransferase
AFLV_RS09680	COG4471	UPF0298 protein
AFLV_RS09685	COG3679	Belongs to the UPF0342 family
AFLV_RS09705	COG2340	Cysteine-rich secretory protein family
AFLV_RS09710	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AFLV_RS09725	COG0628	permease
AFLV_RS09735	COG3336	cytochrome c oxidase
AFLV_RS09760	COG0109	protoheme IX farnesyltransferase activity
AFLV_RS09765	COG1612	heme a metabolic process
AFLV_RS09770	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AFLV_RS09775	COG0772	Belongs to the SEDS family
AFLV_RS09780	COG4838	Belongs to the UPF0358 family
AFLV_RS09785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AFLV_RS09790	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AFLV_RS09805	COG4896	Protein conserved in bacteria
AFLV_RS09820	COG1217	gtp-binding protein TYPA
AFLV_RS09830	COG0483	inositol monophosphate 1-phosphatase activity
AFLV_RS09840	COG4476	Belongs to the UPF0223 family
AFLV_RS09850	COG1982	Orn Lys Arg decarboxylase major
AFLV_RS09900	COG0561	phosphatase activity
AFLV_RS09905	COG5503	Protein of unknown function (DUF1447)
AFLV_RS09910	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFLV_RS09920	COG0569	domain protein
AFLV_RS09925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFLV_RS09930	COG1473	amidohydrolase
AFLV_RS09935	COG2171	N-acyltransferase activity
AFLV_RS09940	COG0517	IMP dehydrogenase activity
AFLV_RS09945	COG4703	Protein of unknown function (DUF1797)
AFLV_RS09955	COG2200	EAL domain
AFLV_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
AFLV_RS09965	COG1408	metallophosphoesterase
AFLV_RS09970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFLV_RS09975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFLV_RS09985	COG0248	Ppx GppA phosphatase
AFLV_RS10015	COG5002	protein histidine kinase activity
AFLV_RS10020	COG0745	RESPONSE REGULATOR receiver
AFLV_RS10030	COG1215	transferase activity, transferring glycosyl groups
AFLV_RS10045	COG0835	chemotaxis
AFLV_RS10045	COG0784	Response regulator, receiver
AFLV_RS10060	COG2205	protein histidine kinase activity
AFLV_RS10075	COG0436	Aminotransferase
AFLV_RS10080	COG2084	Dehydrogenase
AFLV_RS10095	COG2205	protein histidine kinase activity
AFLV_RS10100	COG0840	transmembrane signaling receptor activity
AFLV_RS10115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFLV_RS10115	COG2190	(PTS) system
AFLV_RS10115	COG1263	PTS System
AFLV_RS10120	COG3711	transcriptional antiterminator
AFLV_RS10125	COG0561	phosphatase activity
AFLV_RS10130	COG0791	NLP P60 protein
AFLV_RS10130	COG1388	LysM domain
AFLV_RS10140	COG1320	monovalent cation:proton antiporter activity
AFLV_RS10145	COG2212	antiporter activity
AFLV_RS10150	COG1863	multisubunit Na H antiporter MnhE subunit
AFLV_RS10155	COG0651	ATP synthesis coupled electron transport
AFLV_RS10160	COG1006	Multisubunit Na H antiporter MnhC subunit
AFLV_RS10165	COG2111	Na H antiporter
AFLV_RS10170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFLV_RS10170	COG2111	Na H antiporter
AFLV_RS10175	COG0840	transmembrane signaling receptor activity
AFLV_RS10190	COG1733	regulation of RNA biosynthetic process
AFLV_RS10195	COG0778	Nitroreductase
AFLV_RS10200	COG3852	Histidine kinase
AFLV_RS10220	COG0702	epimerase
AFLV_RS10225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AFLV_RS10240	COG0720	synthase
AFLV_RS10245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AFLV_RS10250	COG0704	Plays a role in the regulation of phosphate uptake
AFLV_RS10265	COG3949	Membrane
AFLV_RS10280	COG0745	RESPONSE REGULATOR receiver
AFLV_RS10285	COG5002	protein histidine kinase activity
AFLV_RS10305	COG0542	response to heat
AFLV_RS10320	COG1131	(ABC) transporter
AFLV_RS10325	COG0531	amino acid
AFLV_RS10340	COG3852	Histidine kinase
AFLV_RS10350	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AFLV_RS10355	COG0235	Class ii aldolase
AFLV_RS10360	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AFLV_RS10365	COG1850	ribulose-bisphosphate carboxylase activity
AFLV_RS10370	COG0436	Aminotransferase
AFLV_RS10375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFLV_RS10380	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AFLV_RS10385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AFLV_RS10390	COG1879	ABC-type sugar transport system periplasmic component
AFLV_RS10395	COG1129	ABC transporter
AFLV_RS10405	COG0840	transmembrane signaling receptor activity
AFLV_RS10410	COG5002	protein histidine kinase activity
AFLV_RS10415	COG1556	Lactate utilization protein
AFLV_RS10420	COG1139	Iron-sulfur cluster binding protein
AFLV_RS10425	COG0247	lactate metabolic process
AFLV_RS10430	COG2186	Transcriptional regulator
AFLV_RS10435	COG1620	l-lactate permease
AFLV_RS10480	COG0395	ABC-type sugar transport system, permease component
AFLV_RS10495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFLV_RS10500	COG1554	hydrolase, family 65, central catalytic
AFLV_RS10505	COG1609	Transcriptional regulator
AFLV_RS10510	COG0840	transmembrane signaling receptor activity
AFLV_RS10515	COG3835	regulator
AFLV_RS10520	COG0277	FAD linked oxidase domain protein
AFLV_RS10525	COG0247	lactate metabolic process
AFLV_RS10535	COG1528	Iron-storage protein
AFLV_RS10540	COG0861	Integral membrane protein TerC family
AFLV_RS10545	COG0531	amino acid
AFLV_RS10560	COG0463	Glycosyl transferase, family 2
AFLV_RS10570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFLV_RS10575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AFLV_RS10600	COG1027	Aspartate ammonia-lyase
AFLV_RS10605	COG0252	asparaginase activity
AFLV_RS10610	COG1396	sequence-specific DNA binding
AFLV_RS10615	COG0515	serine threonine protein kinase
AFLV_RS10630	COG0697	spore germination
AFLV_RS10660	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFLV_RS10665	COG0732	type I restriction modification DNA specificity domain
AFLV_RS10670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AFLV_RS10710	COG1418	mRNA catabolic process
AFLV_RS10715	COG0626	cystathionine gamma-synthase activity
AFLV_RS10720	COG0626	cystathionine gamma-synthase activity
AFLV_RS10725	COG0662	Cupin 2, conserved barrel domain protein
AFLV_RS10730	COG3384	dioxygenase
AFLV_RS10735	COG1970	mechanosensitive ion channel activity
AFLV_RS10740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFLV_RS10745	COG2382	esterase
AFLV_RS10750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AFLV_RS10755	COG2153	protein acetylation
AFLV_RS10760	COG2323	membrane
AFLV_RS10765	COG0210	DNA helicase
AFLV_RS10780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFLV_RS10790	COG2323	membrane
AFLV_RS10805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFLV_RS10855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFLV_RS10860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFLV_RS10865	COG0438	transferase activity, transferring glycosyl groups
AFLV_RS10875	COG3220	belongs to the UPF0276 family
AFLV_RS10895	COG2801	Transposase and inactivated derivatives
AFLV_RS10910	COG2814	Major facilitator Superfamily
AFLV_RS10920	COG2239	Acts as a magnesium transporter
AFLV_RS10925	COG0772	Belongs to the SEDS family
AFLV_RS10940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AFLV_RS10945	COG0564	pseudouridine synthase activity
AFLV_RS10955	COG2357	RelA SpoT domain protein
AFLV_RS10965	COG4116	CYTH
AFLV_RS10970	COG0741	lytic transglycosylase activity
AFLV_RS10975	COG2346	COG2346, Truncated hemoglobins
AFLV_RS10980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFLV_RS10990	COG1164	Oligoendopeptidase f
AFLV_RS11005	COG4862	establishment of competence for transformation
AFLV_RS11010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFLV_RS11015	COG1393	Belongs to the ArsC family
AFLV_RS11025	COG4608	Belongs to the ABC transporter superfamily
AFLV_RS11030	COG0444	Belongs to the ABC transporter superfamily
AFLV_RS11035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFLV_RS11040	COG0601	transmembrane transport
AFLV_RS11045	COG4166	transmembrane transport
AFLV_RS11060	COG0180	Tryptophanyl-tRNA synthetase
AFLV_RS11075	COG5504	Zn-dependent protease
AFLV_RS11080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFLV_RS11085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFLV_RS11090	COG1744	ABC transporter substrate-binding protein PnrA-like
AFLV_RS11095	COG2267	carboxylic ester hydrolase activity
AFLV_RS11105	COG0542	response to heat
AFLV_RS11115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFLV_RS11135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AFLV_RS11140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFLV_RS11145	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFLV_RS11150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AFLV_RS11160	COG1073	alpha beta
AFLV_RS11165	COG0561	phosphatase activity
AFLV_RS11170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AFLV_RS11175	COG1307	EDD domain protein, DegV family
AFLV_RS11180	COG0840	transmembrane signaling receptor activity
AFLV_RS11185	COG1744	ABC transporter substrate-binding protein PnrA-like
AFLV_RS11190	COG1666	GTP binding
AFLV_RS11195	COG0646	methionine synthase
AFLV_RS11195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AFLV_RS11200	COG0646	methionine synthase
AFLV_RS11200	COG1410	methionine synthase
AFLV_RS11205	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AFLV_RS11215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AFLV_RS11220	COG1492	cobalamin metabolic process
AFLV_RS11250	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AFLV_RS11275	COG1122	ATPase activity
AFLV_RS11285	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
AFLV_RS11290	COG0310	cobalt ion transport
AFLV_RS11310	COG0366	Alpha amylase catalytic
AFLV_RS11310	COG1874	Beta-galactosidase
AFLV_RS11315	COG3833	ABC-type maltose transport systems, permease component
AFLV_RS11320	COG1175	transmembrane transport
AFLV_RS11325	COG2182	Extracellular solute-binding protein
AFLV_RS11335	COG2207	Transcriptional regulator
AFLV_RS11335	COG1917	Cupin 2, conserved barrel domain protein
AFLV_RS11340	COG0534	Mate efflux family protein
AFLV_RS11345	COG1233	COG1233 Phytoene dehydrogenase and related
AFLV_RS11350	COG0463	Glycosyl transferase, family 2
AFLV_RS11365	COG1562	ergosterol biosynthetic process
AFLV_RS11380	COG0367	asparagine synthase
AFLV_RS11390	COG5001	Diguanylate cyclase
AFLV_RS11390	COG3300	MHYT domain
AFLV_RS11400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFLV_RS11405	COG0179	Fumarylacetoacetate (FAA) hydrolase
AFLV_RS11415	COG2311	Membrane
AFLV_RS11435	COG0412	Dienelactone hydrolase
AFLV_RS11445	COG3335	DDE superfamily endonuclease
AFLV_RS11465	COG0318	PFAM AMP-dependent synthetase and ligase
AFLV_RS11505	COG1403	HNH endonuclease
AFLV_RS11510	COG0419	ATPase involved in DNA repair
AFLV_RS11515	COG0420	3'-5' exonuclease activity
AFLV_RS11520	COG1074	ATP-dependent DNA helicase activity
AFLV_RS11525	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AFLV_RS11530	COG0398	Pfam SNARE associated Golgi protein
AFLV_RS11550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFLV_RS11555	COG0210	DNA helicase
AFLV_RS11575	COG2224	Isocitrate lyase
AFLV_RS11580	COG0501	Belongs to the peptidase M48B family
AFLV_RS11585	COG1999	signal sequence binding
AFLV_RS11590	COG0840	transmembrane signaling receptor activity
AFLV_RS11610	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AFLV_RS11620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFLV_RS11625	COG4120	Belongs to the binding-protein-dependent transport system permease family
AFLV_RS11635	COG0318	PFAM AMP-dependent synthetase and ligase
AFLV_RS11710	COG0517	IMP dehydrogenase activity
AFLV_RS11710	COG0617	tRNA 3'-terminal CCA addition
AFLV_RS11710	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AFLV_RS11715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AFLV_RS11735	COG1234	tRNA 3'-trailer cleavage
AFLV_RS11740	COG0366	Alpha amylase catalytic
AFLV_RS11755	COG1653	transport
AFLV_RS11760	COG1609	Transcriptional regulator
AFLV_RS11765	COG1511	domain protein
AFLV_RS11770	COG1309	transcriptional regulator
AFLV_RS11775	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AFLV_RS11780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFLV_RS11785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFLV_RS11790	COG2329	Antibiotic biosynthesis monooxygenase
AFLV_RS11795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFLV_RS11800	COG1473	amidohydrolase
AFLV_RS11810	COG1131	(ABC) transporter
AFLV_RS11815	COG0537	adenosine 5'-monophosphoramidase activity
AFLV_RS11820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AFLV_RS11840	COG1846	Transcriptional regulator
AFLV_RS11855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AFLV_RS11870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AFLV_RS11875	COG0561	phosphatase activity
AFLV_RS11880	COG3679	Belongs to the UPF0342 family
AFLV_RS11885	COG4399	Belongs to the UPF0754 family
AFLV_RS11895	COG2508	Transcriptional regulator
AFLV_RS11900	COG3842	ATPase activity
AFLV_RS11915	COG1126	abc transporter atp-binding protein
AFLV_RS11920	COG0765	amino acid transport
AFLV_RS11925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AFLV_RS11930	COG1253	flavin adenine dinucleotide binding
AFLV_RS11935	COG0351	phosphomethylpyrimidine kinase
AFLV_RS11940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFLV_RS11945	COG2022	thiamine diphosphate biosynthetic process
AFLV_RS11955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFLV_RS11960	COG0352	thiamine-phosphate diphosphorylase activity
AFLV_RS11965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AFLV_RS11970	COG1122	ATPase activity
AFLV_RS11975	COG4721	ABC-type cobalt transport system, permease component
AFLV_RS11980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AFLV_RS11995	COG0366	Alpha amylase catalytic
AFLV_RS12000	COG0477	Major facilitator Superfamily
AFLV_RS12005	COG1846	Transcriptional regulator
AFLV_RS12010	COG2719	SpoVR family
AFLV_RS12015	COG0330	HflC and HflK could
AFLV_RS12020	COG0330	HflC and HflK could
AFLV_RS12025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFLV_RS12040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFLV_RS12045	COG0517	IMP dehydrogenase activity
AFLV_RS12055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFLV_RS12065	COG0564	pseudouridine synthase activity
AFLV_RS12075	COG1253	flavin adenine dinucleotide binding
AFLV_RS12080	COG2738	Putative neutral zinc metallopeptidase
AFLV_RS12085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFLV_RS12085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFLV_RS12095	COG0730	response to heat
AFLV_RS12100	COG0425	Belongs to the sulfur carrier protein TusA family
AFLV_RS12105	COG2210	Belongs to the sulfur carrier protein TusA family
AFLV_RS12110	COG0425	Belongs to the sulfur carrier protein TusA family
AFLV_RS12110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFLV_RS12115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFLV_RS12120	COG2718	Belongs to the UPF0229 family
AFLV_RS12125	COG2766	serine protein kinase
AFLV_RS12130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AFLV_RS12145	COG3382	B3 4 domain protein
AFLV_RS12160	COG0395	ABC-type sugar transport system, permease component
AFLV_RS12165	COG1175	transmembrane transport
AFLV_RS12170	COG1653	transport
AFLV_RS12175	COG2723	6-phospho-beta-galactosidase activity
AFLV_RS12285	COG1285	pathogenesis
AFLV_RS12295	COG0640	Transcriptional regulator
AFLV_RS12300	COG1253	flavin adenine dinucleotide binding
AFLV_RS12305	COG0789	Transcriptional regulator
AFLV_RS12315	COG3328	transposase activity
AFLV_RS12340	COG1131	(ABC) transporter
AFLV_RS12380	COG3335	DDE superfamily endonuclease
AFLV_RS12425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFLV_RS12440	COG1979	alcohol dehydrogenase
AFLV_RS12445	COG2155	Conserved Protein
AFLV_RS12450	COG1098	S1 RNA binding domain
AFLV_RS12460	COG0436	Aminotransferase
AFLV_RS12465	COG1522	sequence-specific DNA binding
AFLV_RS12470	COG2032	superoxide dismutase activity
AFLV_RS12495	COG1268	BioY protein
AFLV_RS12500	COG3584	3D domain protein
AFLV_RS12510	COG1252	NADH dehydrogenase
AFLV_RS12515	COG0492	ferredoxin-NADP+ reductase activity
AFLV_RS12520	COG5416	Lipopolysaccharide assembly protein A domain
AFLV_RS12525	COG0316	Belongs to the HesB IscA family
AFLV_RS12530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFLV_RS12540	COG4844	belongs to the
AFLV_RS12545	COG1252	NADH dehydrogenase
AFLV_RS12550	COG4837	Protein of unknown function (DUF1462)
AFLV_RS12555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AFLV_RS12560	COG0083	homoserine kinase activity
AFLV_RS12565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFLV_RS12570	COG0460	homoserine dehydrogenase
AFLV_RS12575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AFLV_RS12580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AFLV_RS12585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AFLV_RS12590	COG0647	UMP catabolic process
AFLV_RS12600	COG2445	Protein of unknown function DUF86
AFLV_RS12615	COG4470	Protein conserved in bacteria
AFLV_RS12625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFLV_RS12630	COG0739	heme binding
AFLV_RS12635	COG0733	neurotransmitter:sodium symporter activity
AFLV_RS12645	COG3377	Domain of unknown function (DUF1805)
AFLV_RS12650	COG0737	Belongs to the 5'-nucleotidase family
AFLV_RS12655	COG0730	response to heat
AFLV_RS12660	COG1801	Protein of unknown function DUF72
AFLV_RS12730	COG0180	Tryptophanyl-tRNA synthetase
AFLV_RS12735	COG3328	transposase activity
AFLV_RS12750	COG3344	reverse transcriptase
AFLV_RS12825	COG0719	Fe-S assembly protein
AFLV_RS12830	COG0822	iron-sulfur transferase activity
AFLV_RS12835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFLV_RS12840	COG0719	Fe-S assembly protein
AFLV_RS12845	COG0396	ATPase activity
AFLV_RS12850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AFLV_RS12855	COG1464	Belongs to the NlpA lipoprotein family
AFLV_RS12860	COG2011	ABC-type metal ion transport system permease component
AFLV_RS12865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AFLV_RS12885	COG2201	protein-glutamate methylesterase activity
AFLV_RS12890	COG2873	o-acetylhomoserine
AFLV_RS12900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFLV_RS12905	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AFLV_RS12915	COG0509	glycine decarboxylation via glycine cleavage system
AFLV_RS12920	COG1393	Belongs to the ArsC family
AFLV_RS12925	COG1960	acyl-CoA dehydrogenase activity
AFLV_RS12930	COG0183	Belongs to the thiolase family
AFLV_RS12935	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFLV_RS12935	COG1024	Enoyl-CoA hydratase
AFLV_RS12945	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFLV_RS12945	COG1024	Enoyl-CoA hydratase
AFLV_RS12950	COG0506	proline dehydrogenase activity
AFLV_RS12960	COG5577	PFAM Coat F domain
AFLV_RS12985	COG0748	coenzyme F420 binding
AFLV_RS12995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AFLV_RS13000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AFLV_RS13005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFLV_RS13010	COG0557	exoribonuclease II activity
AFLV_RS13020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFLV_RS13035	COG3209	COG3209 Rhs family protein
AFLV_RS13095	COG0148	phosphopyruvate hydratase activity
AFLV_RS13100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AFLV_RS13105	COG0149	triose-phosphate isomerase activity
AFLV_RS13110	COG0126	phosphoglycerate kinase activity
AFLV_RS13130	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AFLV_RS13140	COG0740	serine-type endopeptidase activity
AFLV_RS13145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AFLV_RS13150	COG1481	regulation of sporulation
AFLV_RS13155	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AFLV_RS13160	COG1660	Displays ATPase and GTPase activities
AFLV_RS13165	COG1051	belongs to the nudix hydrolase family
AFLV_RS13170	COG0492	ferredoxin-NADP+ reductase activity
AFLV_RS13175	COG0457	Tetratricopeptide repeat
AFLV_RS13180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFLV_RS13180	COG0140	phosphoribosyl-ATP diphosphatase activity
AFLV_RS13185	COG0107	imidazoleglycerol-phosphate synthase activity
AFLV_RS13190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFLV_RS13195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFLV_RS13200	COG0131	Imidazoleglycerol-phosphate dehydratase
AFLV_RS13205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFLV_RS13210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFLV_RS13215	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AFLV_RS13220	COG0110	maltose O-acetyltransferase activity
AFLV_RS13225	COG0546	phosphoglycolate phosphatase activity
AFLV_RS13230	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AFLV_RS13235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFLV_RS13240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AFLV_RS13245	COG1950	PFAM Membrane protein of
AFLV_RS13265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AFLV_RS13270	COG0556	nucleotide-excision repair
AFLV_RS13275	COG4897	Protein conserved in bacteria
AFLV_RS13280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFLV_RS13285	COG0789	Transcriptional regulator
AFLV_RS13290	COG3409	Peptidoglycan-binding domain 1 protein
AFLV_RS13290	COG0793	Belongs to the peptidase S41A family
AFLV_RS13315	COG0739	heme binding
AFLV_RS13320	COG2177	Part of the ABC transporter FtsEX involved in
AFLV_RS13325	COG2884	Cell division ATP-binding protein ftsE
AFLV_RS13335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AFLV_RS13340	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFLV_RS13345	COG0653	protein targeting
AFLV_RS13375	COG1516	flagellar protein fliS
AFLV_RS13380	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AFLV_RS13385	COG1334	flagellar protein FlaG
AFLV_RS13390	COG0463	Glycosyl transferase, family 2
AFLV_RS13390	COG0457	Tetratricopeptide repeat
AFLV_RS13395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AFLV_RS13410	COG0463	Glycosyl transferase, family 2
AFLV_RS13410	COG0457	Tetratricopeptide repeat
AFLV_RS13420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFLV_RS13430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AFLV_RS13435	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AFLV_RS13445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AFLV_RS13450	COG1256	bacterial-type flagellum assembly
AFLV_RS13450	COG4786	Flagellar basal body rod
AFLV_RS13470	COG1728	Protein conserved in bacteria
AFLV_RS13485	COG2257	FlhB HrpN YscU SpaS Family
AFLV_RS13495	COG1040	competence protein
AFLV_RS13500	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AFLV_RS13505	COG1307	EDD domain protein, DegV family
AFLV_RS13515	COG2197	response regulator
AFLV_RS13520	COG4585	Histidine kinase
AFLV_RS13525	COG1739	Uncharacterized protein family UPF0029
AFLV_RS13530	COG1316	TRANSCRIPTIONal
AFLV_RS13535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFLV_RS13545	COG2385	sporulation resulting in formation of a cellular spore
AFLV_RS13545	COG2247	cell wall binding repeat
AFLV_RS13550	COG3266	domain, Protein
AFLV_RS13550	COG2911	Protein conserved in bacteria
AFLV_RS13550	COG1361	Conserved repeat domain
AFLV_RS13560	COG1404	Belongs to the peptidase S8 family
AFLV_RS13565	COG0737	Belongs to the 5'-nucleotidase family
AFLV_RS13630	COG1073	alpha beta
AFLV_RS13635	COG4191	Histidine kinase
AFLV_RS13670	COG2003	Belongs to the UPF0758 family
AFLV_RS13690	COG2801	Transposase and inactivated derivatives
AFLV_RS13725	COG1388	LysM domain
AFLV_RS13725	COG0791	NLP P60 protein
AFLV_RS13730	COG3693	PFAM glycoside hydrolase, family 10
AFLV_RS13740	COG0653	protein targeting
AFLV_RS13755	COG1396	sequence-specific DNA binding
AFLV_RS13770	COG3764	Sortase (surface protein transpeptidase)
AFLV_RS13780	COG0527	aspartate kinase activity
AFLV_RS13785	COG0527	aspartate kinase activity
AFLV_RS13795	COG4903	ComK protein
AFLV_RS13800	COG0840	transmembrane signaling receptor activity
AFLV_RS13815	COG2244	polysaccharide biosynthetic process
AFLV_RS13830	COG1405	negative regulation of cell septum assembly
AFLV_RS13830	COG3012	SEC-C Motif Domain Protein
AFLV_RS13835	COG2996	Protein conserved in bacteria
AFLV_RS13840	COG0673	inositol 2-dehydrogenase activity
AFLV_RS13855	COG3177	Filamentation induced by cAMP protein fic
AFLV_RS13865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AFLV_RS13875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AFLV_RS13880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AFLV_RS13890	COG1879	ABC-type sugar transport system periplasmic component
AFLV_RS13895	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFLV_RS13900	COG1129	ABC transporter
AFLV_RS13905	COG1869	D-ribose catabolic process
AFLV_RS13910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFLV_RS13915	COG1609	Transcriptional regulator
AFLV_RS13920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFLV_RS13940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFLV_RS13950	COG4786	Flagellar basal body rod
AFLV_RS13955	COG4786	Flagellar basal body rod
AFLV_RS13965	COG1077	Cell shape determining protein MreB Mrl
AFLV_RS13970	COG1609	Transcriptional regulator
AFLV_RS13975	COG0739	heme binding
AFLV_RS13980	COG2385	sporulation resulting in formation of a cellular spore
AFLV_RS13985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFLV_RS13995	COG4836	Membrane
AFLV_RS14000	COG1007	ATP synthesis coupled electron transport
AFLV_RS14010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFLV_RS14015	COG0713	ATP synthesis coupled electron transport
AFLV_RS14020	COG0839	Belongs to the complex I subunit 6 family
AFLV_RS14025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFLV_RS14030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFLV_RS14035	COG0649	NAD binding
AFLV_RS14040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFLV_RS14045	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFLV_RS14050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFLV_RS14055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFLV_RS14060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFLV_RS14065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AFLV_RS14070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFLV_RS14075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFLV_RS14080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFLV_RS14085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFLV_RS14090	COG0356	it plays a direct role in the translocation of protons across the membrane
AFLV_RS14105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AFLV_RS14110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AFLV_RS14115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFLV_RS14120	COG4475	Protein of unknown function (DUF436)
AFLV_RS14125	COG0698	ribose 5-phosphate isomerase
AFLV_RS14130	COG0840	transmembrane signaling receptor activity
AFLV_RS14140	COG1971	Probably functions as a manganese efflux pump
AFLV_RS14145	COG0009	L-threonylcarbamoyladenylate synthase
AFLV_RS14155	COG2890	protein-(glutamine-N5) methyltransferase activity
AFLV_RS14160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFLV_RS14165	COG1435	thymidine kinase activity
AFLV_RS14170	COG0254	rRNA binding
AFLV_RS14175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AFLV_RS14180	COG1494	fructose-1,6-bisphosphatase
AFLV_RS14185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFLV_RS14190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFLV_RS14200	COG2204	response regulator
AFLV_RS14205	COG4821	SIS domain
AFLV_RS14210	COG0504	CTP synthase activity
AFLV_RS14215	COG3343	RNA polymerase activity
AFLV_RS14220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFLV_RS14220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFLV_RS14220	COG1703	isobutyryl-CoA mutase activity
AFLV_RS14230	COG1960	acyl-CoA dehydrogenase activity
AFLV_RS14235	COG1960	acyl-CoA dehydrogenase activity
AFLV_RS14240	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFLV_RS14245	COG0183	Belongs to the thiolase family
AFLV_RS14250	COG0247	lactate metabolic process
AFLV_RS14250	COG2181	nitrate reductase activity
AFLV_RS14255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AFLV_RS14260	COG0018	arginyl-trna synthetase
AFLV_RS14295	COG0010	Belongs to the arginase family
AFLV_RS14300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AFLV_RS14305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AFLV_RS14315	COG1994	Peptidase M50
AFLV_RS14325	COG3465	dGTPase activity
AFLV_RS14330	COG1078	dGTPase activity
AFLV_RS14335	COG4844	belongs to the
AFLV_RS14345	COG0095	Lipoate-protein ligase
AFLV_RS14350	COG0280	phosphate acetyltransferase
AFLV_RS14355	COG1238	metal cluster binding
AFLV_RS14360	COG3253	May function as heme-dependent peroxidase
AFLV_RS14365	COG3773	Cell wall hydrolase
AFLV_RS14375	COG2363	Small membrane protein
AFLV_RS14385	COG0366	Alpha amylase catalytic
AFLV_RS14390	COG0475	glutathione-regulated potassium exporter activity
AFLV_RS14390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFLV_RS14400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AFLV_RS14405	COG0423	glycine-tRNA ligase activity
AFLV_RS14410	COG3634	alkyl hydroperoxide reductase activity
AFLV_RS14415	COG0450	alkyl hydroperoxide reductase
AFLV_RS14425	COG1216	Glycosyl transferase, family 2
AFLV_RS14430	COG0477	Major facilitator Superfamily
AFLV_RS14440	COG0295	cytidine deaminase activity
AFLV_RS14450	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AFLV_RS14455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AFLV_RS14460	COG2390	Transcriptional regulator
AFLV_RS14465	COG1621	beta-fructofuranosidase activity
AFLV_RS14470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFLV_RS14475	COG1263	PTS System
AFLV_RS14475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AFLV_RS14480	COG3711	transcriptional antiterminator
AFLV_RS14485	COG2190	(PTS) system
AFLV_RS14490	COG2508	Transcriptional regulator
AFLV_RS14490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AFLV_RS14495	COG0686	Belongs to the AlaDH PNT family
AFLV_RS14505	COG0765	amino acid transport
AFLV_RS14520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AFLV_RS14525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFLV_RS14530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFLV_RS14535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AFLV_RS14545	COG1131	(ABC) transporter
AFLV_RS14580	COG4585	Histidine kinase
AFLV_RS14590	COG1131	(ABC) transporter
AFLV_RS14610	COG1012	belongs to the aldehyde dehydrogenase family
AFLV_RS14610	COG1454	alcohol dehydrogenase
AFLV_RS14625	COG0723	plastoquinol--plastocyanin reductase activity
AFLV_RS14625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFLV_RS14630	COG0697	spore germination
AFLV_RS14635	COG0531	amino acid
AFLV_RS14645	COG3842	ATPase activity
AFLV_RS14650	COG1176	ABC-type spermidine putrescine transport system, permease component I
AFLV_RS14655	COG1177	transmembrane transport
AFLV_RS14660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AFLV_RS14665	COG3104	oligopeptide transport
AFLV_RS14675	COG0577	efflux transmembrane transporter activity
AFLV_RS14675	COG1136	(ABC) transporter
AFLV_RS14720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFLV_RS14725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AFLV_RS14730	COG4853	Protein conserved in bacteria
AFLV_RS14740	COG5002	protein histidine kinase activity
AFLV_RS14745	COG0745	RESPONSE REGULATOR receiver
AFLV_RS14760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFLV_RS14765	COG0305	Participates in initiation and elongation during chromosome replication
AFLV_RS14770	COG0359	binds to the 23S rRNA
AFLV_RS14775	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AFLV_RS14780	COG4241	membrane
AFLV_RS14785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFLV_RS14790	COG0629	single-stranded DNA binding
AFLV_RS14795	COG0360	Binds together with S18 to 16S ribosomal RNA
AFLV_RS14800	COG0012	GTP binding
AFLV_RS14805	COG4481	Protein conserved in bacteria
AFLV_RS14810	COG0668	transmembrane transport
AFLV_RS14820	COG1811	Na channel or pump
AFLV_RS14825	COG1475	DNA binding
AFLV_RS14830	COG1192	Involved in chromosome partitioning
AFLV_RS14835	COG1475	DNA binding
AFLV_RS14840	COG0357	Ribosomal RNA small subunit methyltransferase G
AFLV_RS14845	COG0445	tRNA wobble uridine modification
AFLV_RS14850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AFLV_RS14855	COG1847	R3H domain protein
AFLV_RS14860	COG0706	membrane insertase activity
AFLV_RS14865	COG0594	ribonuclease P activity
AFLV_RS14870	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AFLV_RS14890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFLV_RS14900	COG1454	alcohol dehydrogenase