locus-tag	class	description
IRT44_RS00020	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IRT44_RS00045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_RS00050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_RS00055	COG1253	flavin adenine dinucleotide binding
IRT44_RS00060	COG0210	DNA helicase
IRT44_RS00065	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IRT44_RS00090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_RS00095	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IRT44_RS00105	COG0835	chemotaxis
IRT44_RS00130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IRT44_RS00140	COG4533	DNA binding
IRT44_RS00145	COG0477	Major facilitator Superfamily
IRT44_RS00145	COG2814	Major facilitator Superfamily
IRT44_RS00150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRT44_RS00150	COG1116	anion transmembrane transporter activity
IRT44_RS00155	COG4120	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS00170	COG1253	flavin adenine dinucleotide binding
IRT44_RS00180	COG1595	DNA-templated transcription, initiation
IRT44_RS00190	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IRT44_RS00205	COG2211	Major facilitator Superfamily
IRT44_RS00210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_RS00220	COG0446	pyridine nucleotide-disulphide oxidoreductase
IRT44_RS00220	COG1902	pentaerythritol trinitrate reductase activity
IRT44_RS00235	COG1316	TRANSCRIPTIONal
IRT44_RS00245	COG2223	nitrite transmembrane transporter activity
IRT44_RS00250	COG3012	SEC-C Motif Domain Protein
IRT44_RS00250	COG1405	negative regulation of cell septum assembly
IRT44_RS00265	COG3481	metal-dependent phosphohydrolase, HD sub domain
IRT44_RS00290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IRT44_RS00295	COG0024	Methionine aminopeptidase
IRT44_RS00315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IRT44_RS00320	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IRT44_RS00325	COG0179	Fumarylacetoacetate (FAA) hydrolase
IRT44_RS00330	COG0564	pseudouridine synthase activity
IRT44_RS00340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IRT44_RS00355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IRT44_RS00365	COG3874	Sporulation protein YtfJ
IRT44_RS00375	COG3584	3D domain protein
IRT44_RS00375	COG1388	LysM domain
IRT44_RS00380	COG1376	ErfK ybiS ycfS ynhG family protein
IRT44_RS00395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRT44_RS00405	COG2323	membrane
IRT44_RS00425	COG0726	polysaccharide deacetylase
IRT44_RS00430	COG0861	Integral membrane protein TerC family
IRT44_RS00435	COG4191	Histidine kinase
IRT44_RS00540	COG2801	Transposase and inactivated derivatives
IRT44_RS00545	COG0179	Fumarylacetoacetate (FAA) hydrolase
IRT44_RS00550	COG0301	tRNA thio-modification
IRT44_RS00555	COG1104	cysteine desulfurase activity
IRT44_RS00565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IRT44_RS00580	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
IRT44_RS00590	COG0300	oxidoreductase activity
IRT44_RS00610	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IRT44_RS00615	COG4326	sporulation control protein
IRT44_RS00635	COG2211	Major facilitator Superfamily
IRT44_RS00645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRT44_RS00645	COG2199	diguanylate cyclase activity
IRT44_RS00655	COG1363	Peptidase, m42
IRT44_RS00665	COG2081	HI0933 family
IRT44_RS00670	COG3344	reverse transcriptase
IRT44_RS00680	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IRT44_RS00685	COG1309	transcriptional regulator
IRT44_RS00695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_RS00700	COG2199	diguanylate cyclase activity
IRT44_RS00700	COG2203	Gaf domain
IRT44_RS00720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IRT44_RS00730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IRT44_RS00735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRT44_RS00740	COG0454	-acetyltransferase
IRT44_RS00745	COG0517	IMP dehydrogenase activity
IRT44_RS00750	COG0123	including yeast histone deacetylase and acetoin utilization protein
IRT44_RS00755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IRT44_RS00770	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IRT44_RS00770	COG1605	Chorismate mutase
IRT44_RS00780	COG3118	belongs to the thioredoxin family
IRT44_RS00800	COG2309	aminopeptidase activity
IRT44_RS00805	COG1695	Transcriptional regulator
IRT44_RS00815	COG1733	regulation of RNA biosynthetic process
IRT44_RS00820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRT44_RS00850	COG3344	reverse transcriptase
IRT44_RS00855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_RS00865	COG0436	Aminotransferase
IRT44_RS00870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_RS00880	COG1846	Transcriptional regulator
IRT44_RS00885	COG2814	Major facilitator Superfamily
IRT44_RS00890	COG0315	cyclic pyranopterin monophosphate synthase activity
IRT44_RS00895	COG0314	molybdopterin synthase activity
IRT44_RS00900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IRT44_RS00905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IRT44_RS00935	COG1414	Transcriptional regulator
IRT44_RS00940	COG0656	L-ascorbic acid biosynthetic process
IRT44_RS00960	COG0697	spore germination
IRT44_RS00970	COG0681	Belongs to the peptidase S26 family
IRT44_RS00980	COG1674	ftsk spoiiie
IRT44_RS00990	COG0529	Catalyzes the synthesis of activated sulfate
IRT44_RS00995	COG2046	Belongs to the sulfate adenylyltransferase family
IRT44_RS01000	COG0175	sulfate reduction
IRT44_RS01005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRT44_RS01005	COG1587	Uroporphyrinogen-III synthase
IRT44_RS01015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IRT44_RS01025	COG0483	inositol monophosphate 1-phosphatase activity
IRT44_RS01040	COG0129	dihydroxy-acid dehydratase activity
IRT44_RS01045	COG4948	Mandelate Racemase Muconate Lactonizing
IRT44_RS01055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IRT44_RS01060	COG3344	reverse transcriptase
IRT44_RS01085	COG1376	ErfK ybiS ycfS ynhG family protein
IRT44_RS01095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRT44_RS01115	COG5002	protein histidine kinase activity
IRT44_RS01125	COG0586	Pfam SNARE associated Golgi protein
IRT44_RS01150	COG0488	(ABC) transporter
IRT44_RS01170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRT44_RS01175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRT44_RS01180	COG0765	amino acid transport
IRT44_RS01185	COG1126	abc transporter atp-binding protein
IRT44_RS01195	COG3387	PFAM Glycoside hydrolase 15-related
IRT44_RS01200	COG0395	ABC-type sugar transport system, permease component
IRT44_RS01205	COG1175	transmembrane transport
IRT44_RS01215	COG1609	Transcriptional regulator
IRT44_RS01225	COG0483	inositol monophosphate 1-phosphatase activity
IRT44_RS01235	COG1966	Carbon starvation protein
IRT44_RS01240	COG3279	Response regulator of the LytR AlgR family
IRT44_RS01245	COG3275	phosphorelay sensor kinase activity
IRT44_RS01250	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IRT44_RS01270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IRT44_RS01270	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IRT44_RS01280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_RS01285	COG2357	RelA SpoT domain protein
IRT44_RS01305	COG0826	peptidase U32
IRT44_RS01310	COG4840	Belongs to the UPF0435 family
IRT44_RS01325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_RS01335	COG0189	ligase activity
IRT44_RS01340	COG1473	amidohydrolase
IRT44_RS01350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IRT44_RS01365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_RS01375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_RS01380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_RS01385	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IRT44_RS01390	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IRT44_RS01395	COG0697	spore germination
IRT44_RS01400	COG0531	amino acid
IRT44_RS01415	COG0531	amino acid
IRT44_RS01425	COG0640	Transcriptional regulator
IRT44_RS01430	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IRT44_RS01430	COG1918	ferrous iron import across plasma membrane
IRT44_RS01435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IRT44_RS01440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IRT44_RS01455	COG4214	carbohydrate transport
IRT44_RS01460	COG1129	ABC transporter
IRT44_RS01475	COG1454	alcohol dehydrogenase
IRT44_RS01480	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS01485	COG1609	Transcriptional regulator
IRT44_RS01495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRT44_RS01520	COG2267	carboxylic ester hydrolase activity
IRT44_RS01525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IRT44_RS01530	COG1177	transmembrane transport
IRT44_RS01535	COG1176	ABC-type spermidine putrescine transport system, permease component I
IRT44_RS01545	COG1695	Transcriptional regulator
IRT44_RS01550	COG1879	ABC-type sugar transport system periplasmic component
IRT44_RS01555	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS01560	COG1129	ABC transporter
IRT44_RS01565	COG1869	D-ribose catabolic process
IRT44_RS01570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_RS01575	COG1609	Transcriptional regulator
IRT44_RS01580	COG1556	Lactate utilization protein
IRT44_RS01585	COG1139	Iron-sulfur cluster binding protein
IRT44_RS01590	COG0247	lactate metabolic process
IRT44_RS01595	COG2186	Transcriptional regulator
IRT44_RS01600	COG1620	l-lactate permease
IRT44_RS01610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IRT44_RS01615	COG0454	-acetyltransferase
IRT44_RS01625	COG2070	2-Nitropropane dioxygenase
IRT44_RS01630	COG0494	nUDIX hydrolase
IRT44_RS01645	COG2971	BadF BadG BcrA BcrD
IRT44_RS01650	COG0165	Argininosuccinate lyase
IRT44_RS01655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRT44_RS01665	COG3842	ATPase activity
IRT44_RS01670	COG1840	ABC-type Fe3 transport system, periplasmic component
IRT44_RS01685	COG0840	transmembrane signaling receptor activity
IRT44_RS01695	COG3253	May function as heme-dependent peroxidase
IRT44_RS01700	COG0363	glucosamine-6-phosphate deaminase activity
IRT44_RS01705	COG1737	Transcriptional regulator
IRT44_RS01715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRT44_RS01720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRT44_RS01725	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_RS01730	COG1940	carbohydrate kinase activity
IRT44_RS01740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRT44_RS01745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IRT44_RS01750	COG1085	galactose-1-phosphate uridylyltransferase
IRT44_RS01755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IRT44_RS01765	COG3142	Participates in the control of copper homeostasis
IRT44_RS01770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IRT44_RS01775	COG0720	synthase
IRT44_RS01785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IRT44_RS01795	COG2084	Dehydrogenase
IRT44_RS01805	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS01820	COG1376	ErfK ybiS ycfS ynhG family protein
IRT44_RS01830	COG1116	anion transmembrane transporter activity
IRT44_RS01835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRT44_RS01840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IRT44_RS01845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRT44_RS01865	COG5002	protein histidine kinase activity
IRT44_RS01870	COG0745	RESPONSE REGULATOR receiver
IRT44_RS01895	COG2011	ABC-type metal ion transport system permease component
IRT44_RS01915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRT44_RS01920	COG1832	CoA-binding protein
IRT44_RS01925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IRT44_RS01935	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IRT44_RS01940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_RS01945	COG3584	3D domain protein
IRT44_RS01965	COG1252	NADH dehydrogenase
IRT44_RS02000	COG0316	Belongs to the HesB IscA family
IRT44_RS02010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IRT44_RS02020	COG1252	NADH dehydrogenase
IRT44_RS02025	COG2801	Transposase and inactivated derivatives
IRT44_RS02040	COG4837	Protein of unknown function (DUF1462)
IRT44_RS02045	COG0626	cystathionine gamma-synthase activity
IRT44_RS02050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRT44_RS02055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IRT44_RS02070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRT44_RS02080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IRT44_RS02095	COG2445	Protein of unknown function DUF86
IRT44_RS02105	COG1494	fructose-1,6-bisphosphatase
IRT44_RS02115	COG4470	Protein conserved in bacteria
IRT44_RS02135	COG0420	3'-5' exonuclease activity
IRT44_RS02140	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IRT44_RS02150	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IRT44_RS02155	COG0739	heme binding
IRT44_RS02170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRT44_RS02170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IRT44_RS02180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IRT44_RS02180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IRT44_RS02195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IRT44_RS02195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IRT44_RS02200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IRT44_RS02205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_RS02210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IRT44_RS02215	COG1802	Transcriptional regulator
IRT44_RS02220	COG0346	lactoylglutathione lyase activity
IRT44_RS02225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IRT44_RS02230	COG0840	transmembrane signaling receptor activity
IRT44_RS02240	COG0598	Magnesium transport protein CorA
IRT44_RS02250	COG3377	Domain of unknown function (DUF1805)
IRT44_RS02260	COG0737	Belongs to the 5'-nucleotidase family
IRT44_RS02265	COG0730	response to heat
IRT44_RS02270	COG1801	Protein of unknown function DUF72
IRT44_RS02290	COG0697	spore germination
IRT44_RS02295	COG2268	Band 7 protein
IRT44_RS02300	COG1585	Membrane protein implicated in regulation of membrane protease activity
IRT44_RS02305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_RS02310	COG0697	spore germination
IRT44_RS02315	COG1363	Peptidase, m42
IRT44_RS02335	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_RS02365	COG0719	Fe-S assembly protein
IRT44_RS02370	COG0822	iron-sulfur transferase activity
IRT44_RS02375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRT44_RS02380	COG0719	Fe-S assembly protein
IRT44_RS02385	COG0396	ATPase activity
IRT44_RS02390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IRT44_RS02395	COG1473	amidohydrolase
IRT44_RS02415	COG0509	glycine decarboxylation via glycine cleavage system
IRT44_RS02420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_RS02425	COG0450	alkyl hydroperoxide reductase
IRT44_RS02430	COG0436	Aminotransferase
IRT44_RS02435	COG1393	Belongs to the ArsC family
IRT44_RS02455	COG1126	abc transporter atp-binding protein
IRT44_RS02470	COG0477	Major facilitator Superfamily
IRT44_RS02475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRT44_RS02480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IRT44_RS02485	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IRT44_RS02495	COG1595	DNA-templated transcription, initiation
IRT44_RS02505	COG1850	ribulose-bisphosphate carboxylase activity
IRT44_RS02510	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
IRT44_RS02515	COG0235	Class ii aldolase
IRT44_RS02520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IRT44_RS02525	COG1960	acyl-CoA dehydrogenase activity
IRT44_RS02530	COG0183	Belongs to the thiolase family
IRT44_RS02535	COG1024	Enoyl-CoA hydratase
IRT44_RS02535	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRT44_RS02550	COG1131	(ABC) transporter
IRT44_RS02570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRT44_RS02585	COG5577	PFAM Coat F domain
IRT44_RS02590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_RS02595	COG1279	arginine transmembrane transporter activity
IRT44_RS02630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IRT44_RS02640	COG1122	ATPase activity
IRT44_RS02650	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
IRT44_RS02655	COG0310	cobalt ion transport
IRT44_RS02660	COG0167	dihydroorotate dehydrogenase activity
IRT44_RS02685	COG0686	Belongs to the AlaDH PNT family
IRT44_RS02690	COG2508	Transcriptional regulator
IRT44_RS02690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IRT44_RS02695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRT44_RS02700	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRT44_RS02705	COG0022	dehydrogenase e1 component
IRT44_RS02710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IRT44_RS02715	COG0095	Lipoate-protein ligase
IRT44_RS02720	COG3284	Transcriptional regulator
IRT44_RS02725	COG2201	protein-glutamate methylesterase activity
IRT44_RS02740	COG4191	Histidine kinase
IRT44_RS02745	COG1506	peptidase
IRT44_RS02750	COG1098	S1 RNA binding domain
IRT44_RS02760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IRT44_RS02770	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IRT44_RS02780	COG2267	carboxylic ester hydrolase activity
IRT44_RS02800	COG1280	lysine exporter protein (LysE YggA)
IRT44_RS02805	COG0788	formyltetrahydrofolate deformylase activity
IRT44_RS02820	COG3852	Histidine kinase
IRT44_RS02830	COG1309	transcriptional regulator
IRT44_RS02835	COG0842	Transport permease protein
IRT44_RS02840	COG1131	(ABC) transporter
IRT44_RS02845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_RS02850	COG0531	amino acid
IRT44_RS02860	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IRT44_RS02865	COG0419	ATPase involved in DNA repair
IRT44_RS02875	COG1612	heme a metabolic process
IRT44_RS02880	COG0109	protoheme IX farnesyltransferase activity
IRT44_RS02890	COG3336	cytochrome c oxidase
IRT44_RS02910	COG2010	Cytochrome c
IRT44_RS02910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IRT44_RS02920	COG2814	Major facilitator Superfamily
IRT44_RS02925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRT44_RS02935	COG4667	esterase of the alpha-beta hydrolase superfamily
IRT44_RS02950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IRT44_RS02970	COG0714	Associated with various cellular activities
IRT44_RS02985	COG1131	(ABC) transporter
IRT44_RS03000	COG2076	Multidrug Resistance protein
IRT44_RS03010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRT44_RS03025	COG0789	Transcriptional regulator
IRT44_RS03030	COG3359	exonuclease
IRT44_RS03035	COG1111	helicase
IRT44_RS03035	COG1205	dead DEAH box helicase
IRT44_RS03040	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_RS03055	COG4175	Glycine betaine
IRT44_RS03055	COG0517	IMP dehydrogenase activity
IRT44_RS03060	COG1510	regulation of RNA biosynthetic process
IRT44_RS03065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IRT44_RS03070	COG4607	ABC-type enterochelin transport system periplasmic component
IRT44_RS03075	COG4604	ABC transporter, ATP-binding protein
IRT44_RS03080	COG4605	iron ion homeostasis
IRT44_RS03085	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS03115	COG1136	(ABC) transporter
IRT44_RS03115	COG0577	efflux transmembrane transporter activity
IRT44_RS03120	COG1136	(ABC) transporter
IRT44_RS03125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_RS03135	COG5002	protein histidine kinase activity
IRT44_RS03145	COG0840	transmembrane signaling receptor activity
IRT44_RS03150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_RS03155	COG2132	Multicopper oxidase
IRT44_RS03165	COG1846	Transcriptional regulator
IRT44_RS03200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IRT44_RS03205	COG0557	exoribonuclease II activity
IRT44_RS03210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IRT44_RS03220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRT44_RS03230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_RS03235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS03240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS03250	COG0148	phosphopyruvate hydratase activity
IRT44_RS03255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IRT44_RS03260	COG0149	triose-phosphate isomerase activity
IRT44_RS03265	COG0126	phosphoglycerate kinase activity
IRT44_RS03275	COG1757	Na H antiporter
IRT44_RS03290	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IRT44_RS03330	COG0740	serine-type endopeptidase activity
IRT44_RS03345	COG1660	Displays ATPase and GTPase activities
IRT44_RS03350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_RS03355	COG1481	regulation of sporulation
IRT44_RS03360	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IRT44_RS03365	COG1660	Displays ATPase and GTPase activities
IRT44_RS03370	COG0492	ferredoxin-NADP+ reductase activity
IRT44_RS03425	COG2358	TRAP transporter, solute receptor (TAXI family
IRT44_RS03430	COG2204	response regulator
IRT44_RS03435	COG3852	Histidine kinase
IRT44_RS03445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IRT44_RS03445	COG0140	phosphoribosyl-ATP diphosphatase activity
IRT44_RS03450	COG0107	imidazoleglycerol-phosphate synthase activity
IRT44_RS03455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IRT44_RS03460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IRT44_RS03465	COG0131	Imidazoleglycerol-phosphate dehydratase
IRT44_RS03470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IRT44_RS03475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IRT44_RS03480	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IRT44_RS03485	COG0110	maltose O-acetyltransferase activity
IRT44_RS03490	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IRT44_RS03495	COG3290	protein histidine kinase activity
IRT44_RS03505	COG1418	mRNA catabolic process
IRT44_RS03510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IRT44_RS03515	COG0556	nucleotide-excision repair
IRT44_RS03520	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IRT44_RS03530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRT44_RS03535	COG0793	Belongs to the peptidase S41A family
IRT44_RS03535	COG3409	Peptidoglycan-binding domain 1 protein
IRT44_RS03540	COG0739	heme binding
IRT44_RS03545	COG2177	Part of the ABC transporter FtsEX involved in
IRT44_RS03550	COG2884	Cell division ATP-binding protein ftsE
IRT44_RS03555	COG1979	alcohol dehydrogenase
IRT44_RS03560	COG3344	reverse transcriptase
IRT44_RS03565	COG0165	Argininosuccinate lyase
IRT44_RS03570	COG0137	argininosuccinate synthase activity
IRT44_RS03580	COG2199	diguanylate cyclase activity
IRT44_RS03580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRT44_RS03590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IRT44_RS03595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IRT44_RS03600	COG0505	Belongs to the CarA family
IRT44_RS03605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRT44_RS03610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IRT44_RS03615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IRT44_RS03640	COG0653	protein targeting
IRT44_RS03645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IRT44_RS03650	COG1278	Cold shock
IRT44_RS03655	COG0765	amino acid transport
IRT44_RS03685	COG3344	reverse transcriptase
IRT44_RS03700	COG1516	flagellar protein fliS
IRT44_RS03705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IRT44_RS03710	COG1334	flagellar protein FlaG
IRT44_RS03715	COG0463	Glycosyl transferase, family 2
IRT44_RS03720	COG0457	Tetratricopeptide repeat
IRT44_RS03720	COG0463	Glycosyl transferase, family 2
IRT44_RS03725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRT44_RS03730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IRT44_RS03735	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IRT44_RS03745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IRT44_RS03750	COG1256	bacterial-type flagellum assembly
IRT44_RS03750	COG4786	Flagellar basal body rod
IRT44_RS03775	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IRT44_RS03785	COG2197	response regulator
IRT44_RS03795	COG0726	polysaccharide deacetylase
IRT44_RS03795	COG1649	PFAM Uncharacterised BCR, COG1649
IRT44_RS03800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IRT44_RS03810	COG1404	Belongs to the peptidase S8 family
IRT44_RS03835	COG0667	Aldo Keto reductase
IRT44_RS03840	COG0840	transmembrane signaling receptor activity
IRT44_RS03875	COG3209	COG3209 Rhs family protein
IRT44_RS03895	COG3209	COG3209 Rhs family protein
IRT44_RS03915	COG3209	COG3209 Rhs family protein
IRT44_RS03955	COG0544	peptidyl-prolyl cis-trans isomerase activity
IRT44_RS03970	COG1739	Uncharacterized protein family UPF0029
IRT44_RS03985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRT44_RS03995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IRT44_RS04010	COG4786	Flagellar basal body rod
IRT44_RS04020	COG4786	Flagellar basal body rod
IRT44_RS04030	COG1609	Transcriptional regulator
IRT44_RS04035	COG0739	heme binding
IRT44_RS04040	COG2385	sporulation resulting in formation of a cellular spore
IRT44_RS04045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRT44_RS04055	COG4836	Membrane
IRT44_RS04060	COG1007	ATP synthesis coupled electron transport
IRT44_RS04070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IRT44_RS04075	COG0713	ATP synthesis coupled electron transport
IRT44_RS04080	COG0839	Belongs to the complex I subunit 6 family
IRT44_RS04085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRT44_RS04090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IRT44_RS04095	COG0649	NAD binding
IRT44_RS04100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRT44_RS04105	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRT44_RS04110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IRT44_RS04120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IRT44_RS04125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IRT44_RS04130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IRT44_RS04135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IRT44_RS04140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IRT44_RS04145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IRT44_RS04155	COG0356	it plays a direct role in the translocation of protons across the membrane
IRT44_RS04175	COG4106	trans-aconitate 2-methyltransferase activity
IRT44_RS04190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IRT44_RS04200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IRT44_RS04205	COG1361	Conserved repeat domain
IRT44_RS04210	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IRT44_RS04215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IRT44_RS04225	COG2801	Transposase and inactivated derivatives
IRT44_RS04235	COG4475	Protein of unknown function (DUF436)
IRT44_RS04240	COG0698	ribose 5-phosphate isomerase
IRT44_RS04250	COG1971	Probably functions as a manganese efflux pump
IRT44_RS04255	COG0009	L-threonylcarbamoyladenylate synthase
IRT44_RS04265	COG2890	protein-(glutamine-N5) methyltransferase activity
IRT44_RS04270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IRT44_RS04285	COG0254	rRNA binding
IRT44_RS04295	COG0739	heme binding
IRT44_RS04300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IRT44_RS04305	COG1494	fructose-1,6-bisphosphatase
IRT44_RS04310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRT44_RS04315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IRT44_RS04320	COG0191	fructose-bisphosphate aldolase activity
IRT44_RS04335	COG0504	CTP synthase activity
IRT44_RS04340	COG3343	RNA polymerase activity
IRT44_RS04345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IRT44_RS04350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRT44_RS04355	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRT44_RS04355	COG1703	isobutyryl-CoA mutase activity
IRT44_RS04355	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRT44_RS04360	COG1309	transcriptional regulator
IRT44_RS04370	COG1960	acyl-CoA dehydrogenase activity
IRT44_RS04375	COG1960	acyl-CoA dehydrogenase activity
IRT44_RS04380	COG1250	3-hydroxyacyl-CoA dehydrogenase
IRT44_RS04385	COG0183	Belongs to the thiolase family
IRT44_RS04405	COG0247	lactate metabolic process
IRT44_RS04405	COG2181	nitrate reductase activity
IRT44_RS04410	COG1509	lysine 2,3-aminomutase activity
IRT44_RS04415	COG3829	transcription factor binding
IRT44_RS04440	COG0010	Belongs to the arginase family
IRT44_RS04445	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRT44_RS04450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IRT44_RS04490	COG3465	dGTPase activity
IRT44_RS04495	COG1078	dGTPase activity
IRT44_RS04540	COG3391	amine dehydrogenase activity
IRT44_RS04545	COG0564	pseudouridine synthase activity
IRT44_RS04585	COG0116	Belongs to the methyltransferase superfamily
IRT44_RS04595	COG1564	THIamine pyrophosphokinase
IRT44_RS04600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IRT44_RS04610	COG2249	NAD(P)H dehydrogenase (quinone) activity
IRT44_RS04620	COG1309	transcriptional regulator
IRT44_RS04630	COG0405	Gamma-glutamyltransferase
IRT44_RS04635	COG0840	transmembrane signaling receptor activity
IRT44_RS04640	COG0584	glycerophosphoryl diester phosphodiesterase
IRT44_RS04650	COG0395	ABC-type sugar transport system, permease component
IRT44_RS04655	COG1175	transmembrane transport
IRT44_RS04665	COG2801	Transposase and inactivated derivatives
IRT44_RS04675	COG0813	purine-nucleoside phosphorylase activity
IRT44_RS04680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRT44_RS04685	COG1079	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS04690	COG4603	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS04695	COG3845	ABC transporter
IRT44_RS04700	COG1744	ABC transporter substrate-binding protein PnrA-like
IRT44_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_RS04720	COG2610	gluconate transmembrane transporter activity
IRT44_RS04725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IRT44_RS04730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IRT44_RS04735	COG0667	Aldo Keto reductase
IRT44_RS04745	COG2814	Major facilitator Superfamily
IRT44_RS04750	COG1733	regulation of RNA biosynthetic process
IRT44_RS04755	COG3290	protein histidine kinase activity
IRT44_RS04755	COG3829	transcription factor binding
IRT44_RS04760	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IRT44_RS04770	COG1131	(ABC) transporter
IRT44_RS04785	COG1115	amino acid carrier protein
IRT44_RS04790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_RS04800	COG0246	Mannitol dehydrogenase
IRT44_RS04810	COG3711	transcriptional antiterminator
IRT44_RS04820	COG0584	glycerophosphoryl diester phosphodiesterase
IRT44_RS04830	COG0500	methyltransferase
IRT44_RS04835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRT44_RS04850	COG5002	protein histidine kinase activity
IRT44_RS04860	COG5002	protein histidine kinase activity
IRT44_RS04870	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_RS04870	COG0204	Acyl-transferase
IRT44_RS04875	COG2814	Major facilitator Superfamily
IRT44_RS04880	COG0534	Mate efflux family protein
IRT44_RS04890	COG1132	(ABC) transporter
IRT44_RS04895	COG1132	(ABC) transporter
IRT44_RS04900	COG1120	ATPase activity
IRT44_RS04905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS04910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS04925	COG3037	sugar-specific permease SgaT UlaA
IRT44_RS04935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_RS04940	COG0579	oxidoreductase
IRT44_RS04965	COG2814	Major facilitator Superfamily
IRT44_RS04970	COG2814	Major facilitator Superfamily
IRT44_RS04980	COG1309	transcriptional regulator
IRT44_RS04990	COG0640	Transcriptional regulator
IRT44_RS05035	COG2378	regulation of single-species biofilm formation
IRT44_RS05050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IRT44_RS05065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IRT44_RS05075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IRT44_RS05080	COG4853	Protein conserved in bacteria
IRT44_RS05090	COG5002	protein histidine kinase activity
IRT44_RS05095	COG0745	RESPONSE REGULATOR receiver
IRT44_RS05100	COG1196	nuclear chromosome segregation
IRT44_RS05100	COG0739	heme binding
IRT44_RS05100	COG0741	lytic transglycosylase activity
IRT44_RS05115	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IRT44_RS05125	COG0359	binds to the 23S rRNA
IRT44_RS05130	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IRT44_RS05140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IRT44_RS05145	COG0629	single-stranded DNA binding
IRT44_RS05150	COG0360	Binds together with S18 to 16S ribosomal RNA
IRT44_RS05155	COG0012	GTP binding
IRT44_RS05160	COG1164	Oligoendopeptidase f
IRT44_RS05170	COG4481	Protein conserved in bacteria
IRT44_RS05175	COG0668	transmembrane transport
IRT44_RS05190	COG1597	lipid kinase activity
IRT44_RS05195	COG0640	Transcriptional regulator
IRT44_RS05200	COG0697	spore germination
IRT44_RS05210	COG0431	NADPH-dependent FMN reductase
IRT44_RS05220	COG1811	Na channel or pump
IRT44_RS05225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IRT44_RS05230	COG1475	DNA binding
IRT44_RS05235	COG1192	Involved in chromosome partitioning
IRT44_RS05240	COG1475	DNA binding
IRT44_RS05245	COG1285	pathogenesis
IRT44_RS05250	COG0357	Ribosomal RNA small subunit methyltransferase G
IRT44_RS05255	COG0445	tRNA wobble uridine modification
IRT44_RS05260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IRT44_RS05270	COG1847	R3H domain protein
IRT44_RS05275	COG0706	membrane insertase activity
IRT44_RS05280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IRT44_RS05285	COG0594	ribonuclease P activity
IRT44_RS05290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IRT44_RS05300	COG0592	DNA-directed DNA polymerase activity
IRT44_RS05305	COG2501	S4 domain
IRT44_RS05310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IRT44_RS05320	COG0187	DNA topoisomerase II activity
IRT44_RS05325	COG2814	Major facilitator Superfamily
IRT44_RS05335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRT44_RS05340	COG3437	response regulator, receiver
IRT44_RS05365	COG0517	IMP dehydrogenase activity
IRT44_RS05365	COG0516	GMP reductase activity
IRT44_RS05380	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IRT44_RS05385	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IRT44_RS05390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IRT44_RS05400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IRT44_RS05405	COG2224	Isocitrate lyase
IRT44_RS05450	COG1733	regulation of RNA biosynthetic process
IRT44_RS05480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRT44_RS05480	COG1263	PTS System
IRT44_RS05485	COG2190	(PTS) system
IRT44_RS05490	COG3711	transcriptional antiterminator
IRT44_RS05500	COG2318	DinB family
IRT44_RS05510	COG0590	tRNA wobble adenosine to inosine editing
IRT44_RS05515	COG1187	pseudouridine synthase activity
IRT44_RS05540	COG2199	diguanylate cyclase activity
IRT44_RS05540	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IRT44_RS05550	COG3852	Histidine kinase
IRT44_RS05560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IRT44_RS05565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IRT44_RS05600	COG1982	Orn Lys Arg decarboxylase major
IRT44_RS05605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IRT44_RS05610	COG3870	Protein conserved in bacteria
IRT44_RS05615	COG1728	Protein conserved in bacteria
IRT44_RS05620	COG0470	DNA polymerase III
IRT44_RS05625	COG1774	PSP1 C-terminal conserved region
IRT44_RS05630	COG4467	Involved in initiation control of chromosome replication
IRT44_RS05635	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IRT44_RS05640	COG2827	Endonuclease containing a URI domain
IRT44_RS05645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IRT44_RS05650	COG2002	toxin-antitoxin pair type II binding
IRT44_RS05655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRT44_RS05655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IRT44_RS05660	COG0084	hydrolase, TatD family'
IRT44_RS05670	COG3583	domain protein
IRT44_RS05670	COG3584	3D domain protein
IRT44_RS05680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IRT44_RS05685	COG4466	Protein conserved in bacteria
IRT44_RS05700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IRT44_RS05705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRT44_RS05710	COG0251	oxidation-reduction process
IRT44_RS05715	COG2088	sporulation resulting in formation of a cellular spore
IRT44_RS05725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IRT44_RS05730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IRT44_RS05735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IRT44_RS05740	COG0193	aminoacyl-tRNA hydrolase activity
IRT44_RS05750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IRT44_RS05755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IRT44_RS05760	COG2002	toxin-antitoxin pair type II binding
IRT44_RS05765	COG2244	polysaccharide biosynthetic process
IRT44_RS05770	COG3956	TIGRFAM MazG family protein
IRT44_RS05775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IRT44_RS05805	COG1098	S1 RNA binding domain
IRT44_RS05810	COG2208	phosphoserine phosphatase activity
IRT44_RS05815	COG2304	oxidoreductase activity
IRT44_RS05820	COG0515	serine threonine protein kinase
IRT44_RS05830	COG3610	response to peptide
IRT44_RS05835	COG0037	tRNA processing
IRT44_RS05840	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IRT44_RS05845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRT44_RS05860	COG0561	phosphatase activity
IRT44_RS05865	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IRT44_RS05875	COG0803	Belongs to the bacterial solute-binding protein 9 family
IRT44_RS05880	COG1121	(ABC) transporter
IRT44_RS05885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IRT44_RS05890	COG0735	belongs to the Fur family
IRT44_RS05895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IRT44_RS05905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IRT44_RS05935	COG0616	signal peptide processing
IRT44_RS05955	COG2894	cell division
IRT44_RS06070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IRT44_RS06075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IRT44_RS06080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRT44_RS06090	COG0512	Glutamine amidotransferase of anthranilate synthase
IRT44_RS06100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IRT44_RS06105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRT44_RS06110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IRT44_RS06115	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IRT44_RS06120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IRT44_RS06125	COG1396	sequence-specific DNA binding
IRT44_RS06130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IRT44_RS06135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IRT44_RS06170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IRT44_RS06185	COG3880	PFAM UvrB UvrC protein
IRT44_RS06190	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IRT44_RS06195	COG0542	response to heat
IRT44_RS06200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IRT44_RS06210	COG1183	phosphatidylcholine synthase activity
IRT44_RS06225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IRT44_RS06230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IRT44_RS06235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IRT44_RS06240	COG1045	serine acetyltransferase
IRT44_RS06245	COG0215	cysteine-tRNA ligase activity
IRT44_RS06250	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IRT44_RS06255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRT44_RS06260	COG3688	RNA-binding protein containing a PIN domain
IRT44_RS06270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IRT44_RS06280	COG0250	Participates in transcription elongation, termination and antitermination
IRT44_RS06285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IRT44_RS06290	COG0081	regulation of translation
IRT44_RS06295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IRT44_RS06300	COG0222	ribosome binding
IRT44_RS06305	COG2813	Specifically methylates the guanine in position
IRT44_RS06310	COG0085	RNA polymerase activity
IRT44_RS06315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IRT44_RS06320	COG1358	cellular component organization or biogenesis
IRT44_RS06325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IRT44_RS06330	COG0049	tRNA binding
IRT44_RS06335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IRT44_RS06340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IRT44_RS06355	COG0051	transcription antitermination factor activity, RNA binding
IRT44_RS06360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IRT44_RS06365	COG0088	Forms part of the polypeptide exit tunnel
IRT44_RS06370	COG0089	rRNA binding
IRT44_RS06375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IRT44_RS06380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IRT44_RS06385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IRT44_RS06390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IRT44_RS06395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IRT44_RS06400	COG0255	Belongs to the universal ribosomal protein uL29 family
IRT44_RS06405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IRT44_RS06410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IRT44_RS06415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IRT44_RS06420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IRT44_RS06425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IRT44_RS06430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IRT44_RS06435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IRT44_RS06440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IRT44_RS06445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IRT44_RS06450	COG1841	ribosomal large subunit assembly
IRT44_RS06455	COG0200	Binds to the 23S rRNA
IRT44_RS06460	COG0201	protein transport
IRT44_RS06465	COG0563	adenylate kinase activity
IRT44_RS06470	COG0024	Methionine aminopeptidase
IRT44_RS06475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IRT44_RS06480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IRT44_RS06485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IRT44_RS06490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IRT44_RS06495	COG0202	RNA polymerase activity
IRT44_RS06500	COG0203	ribosomal protein L17
IRT44_RS06505	COG1122	ATPase activity
IRT44_RS06510	COG1122	ATPase activity
IRT44_RS06515	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IRT44_RS06520	COG0101	tRNA pseudouridine synthase activity
IRT44_RS06525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IRT44_RS06530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IRT44_RS06535	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_RS06540	COG0489	protein tyrosine kinase activity
IRT44_RS06555	COG0726	polysaccharide deacetylase
IRT44_RS06645	COG0010	Belongs to the arginase family
IRT44_RS06655	COG1595	DNA-templated transcription, initiation
IRT44_RS06660	COG5662	AntiSigma factor
IRT44_RS06665	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IRT44_RS06675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRT44_RS06680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IRT44_RS06710	COG0604	alcohol dehydrogenase
IRT44_RS06715	COG1733	regulation of RNA biosynthetic process
IRT44_RS06730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS06735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS06740	COG1120	ATPase activity
IRT44_RS06750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IRT44_RS06755	COG2814	Major facilitator Superfamily
IRT44_RS06800	COG0745	RESPONSE REGULATOR receiver
IRT44_RS06805	COG3850	Histidine kinase
IRT44_RS06805	COG5002	protein histidine kinase activity
IRT44_RS06820	COG3279	Response regulator of the LytR AlgR family
IRT44_RS06825	COG0427	acetyl-CoA hydrolase
IRT44_RS06840	COG2259	Doxx family
IRT44_RS06845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IRT44_RS06850	COG1846	Transcriptional regulator
IRT44_RS06860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_RS06865	COG2313	pseudouridylate synthase activity
IRT44_RS06870	COG2217	Heavy metal translocating P-type atpase
IRT44_RS06880	COG2608	mercury ion transmembrane transporter activity
IRT44_RS06895	COG2207	Transcriptional regulator
IRT44_RS06895	COG4753	response regulator
IRT44_RS06900	COG2972	Histidine kinase
IRT44_RS06910	COG2188	Transcriptional regulator
IRT44_RS06915	COG1263	PTS System
IRT44_RS06915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRT44_RS06920	COG0366	Alpha amylase catalytic
IRT44_RS06925	COG0561	phosphatase activity
IRT44_RS06945	COG1971	Probably functions as a manganese efflux pump
IRT44_RS06950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IRT44_RS06975	COG4585	Histidine kinase
IRT44_RS06980	COG2197	response regulator
IRT44_RS06990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IRT44_RS06995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRT44_RS07005	COG0778	Nitroreductase
IRT44_RS07010	COG5002	protein histidine kinase activity
IRT44_RS07015	COG0745	RESPONSE REGULATOR receiver
IRT44_RS07030	COG2610	gluconate transmembrane transporter activity
IRT44_RS07035	COG1929	Belongs to the glycerate kinase type-1 family
IRT44_RS07040	COG0840	transmembrane signaling receptor activity
IRT44_RS07050	COG3835	regulator
IRT44_RS07060	COG0475	glutathione-regulated potassium exporter activity
IRT44_RS07085	COG1522	sequence-specific DNA binding
IRT44_RS07090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRT44_RS07110	COG0740	serine-type endopeptidase activity
IRT44_RS07145	COG0583	DNA-binding transcription factor activity
IRT44_RS07150	COG0372	Belongs to the citrate synthase family
IRT44_RS07155	COG1349	DNA-binding transcription factor activity
IRT44_RS07160	COG1105	Belongs to the carbohydrate kinase PfkB family
IRT44_RS07165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_RS07165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRT44_RS07165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IRT44_RS07170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_RS07185	COG1902	pentaerythritol trinitrate reductase activity
IRT44_RS07195	COG5583	Uncharacterized small protein (DUF2292)
IRT44_RS07220	COG0714	Associated with various cellular activities
IRT44_RS07235	COG0425	Belongs to the sulfur carrier protein TusA family
IRT44_RS07235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRT44_RS07240	COG1999	signal sequence binding
IRT44_RS07250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IRT44_RS07260	COG0667	Aldo Keto reductase
IRT44_RS07270	COG1316	TRANSCRIPTIONal
IRT44_RS07290	COG4166	transmembrane transport
IRT44_RS07305	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_RS07315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IRT44_RS07320	COG0573	inorganic phosphate transmembrane transporter activity
IRT44_RS07325	COG0581	inorganic phosphate transmembrane transporter activity
IRT44_RS07330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRT44_RS07335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IRT44_RS07340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IRT44_RS07360	COG0640	Transcriptional regulator
IRT44_RS07375	COG0736	holo-[acyl-carrier-protein] synthase activity
IRT44_RS07380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IRT44_RS07390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IRT44_RS07395	COG0864	Transcriptional regulator
IRT44_RS07400	COG2337	Toxic component of a toxin-antitoxin (TA) module
IRT44_RS07405	COG2172	sigma factor antagonist activity
IRT44_RS07410	COG2208	phosphoserine phosphatase activity
IRT44_RS07420	COG2172	sigma factor antagonist activity
IRT44_RS07425	COG1191	sigma factor activity
IRT44_RS07430	COG2183	response to ionizing radiation
IRT44_RS07445	COG3091	SprT-like family
IRT44_RS07450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IRT44_RS07455	COG0802	atpase or kinase
IRT44_RS07460	COG1214	PFAM Peptidase M22, glycoprotease
IRT44_RS07465	COG0456	acetyltransferase
IRT44_RS07470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IRT44_RS07480	COG0488	(ABC) transporter
IRT44_RS07485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IRT44_RS07490	COG0521	Mo-molybdopterin cofactor biosynthetic process
IRT44_RS07490	COG0315	cyclic pyranopterin monophosphate synthase activity
IRT44_RS07505	COG0805	protein transport
IRT44_RS07515	COG2801	Transposase and inactivated derivatives
IRT44_RS07525	COG2340	Cysteine-rich secretory protein family
IRT44_RS07530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IRT44_RS07540	COG2182	Extracellular solute-binding protein
IRT44_RS07545	COG1175	transmembrane transport
IRT44_RS07550	COG0395	ABC-type sugar transport system, permease component
IRT44_RS07685	COG0714	Associated with various cellular activities
IRT44_RS07695	COG1305	Transglutaminase-like
IRT44_RS07700	COG0519	Catalyzes the synthesis of GMP from XMP
IRT44_RS07700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IRT44_RS07705	COG2252	PERMEase
IRT44_RS07710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IRT44_RS07715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IRT44_RS07720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IRT44_RS07730	COG2801	Transposase and inactivated derivatives
IRT44_RS07770	COG1136	(ABC) transporter
IRT44_RS07785	COG0745	RESPONSE REGULATOR receiver
IRT44_RS07790	COG2205	protein histidine kinase activity
IRT44_RS07795	COG1136	(ABC) transporter
IRT44_RS07800	COG0577	efflux transmembrane transporter activity
IRT44_RS07810	COG0747	negative chemotaxis
IRT44_RS07820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_RS07825	COG0444	Belongs to the ABC transporter superfamily
IRT44_RS07830	COG4608	Belongs to the ABC transporter superfamily
IRT44_RS07835	COG2059	Chromate
IRT44_RS07840	COG2059	Chromate
IRT44_RS07845	COG0405	Gamma-glutamyltransferase
IRT44_RS07850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IRT44_RS07870	COG1459	type II secretion system
IRT44_RS07885	COG2304	oxidoreductase activity
IRT44_RS07890	COG2304	oxidoreductase activity
IRT44_RS07895	COG2304	oxidoreductase activity
IRT44_RS07920	COG2304	oxidoreductase activity
IRT44_RS07935	COG2304	oxidoreductase activity
IRT44_RS07950	COG1979	alcohol dehydrogenase
IRT44_RS07960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IRT44_RS07965	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRT44_RS07970	COG0047	phosphoribosylformylglycinamidine synthase activity
IRT44_RS07975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IRT44_RS07980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IRT44_RS07985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IRT44_RS07990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IRT44_RS08025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IRT44_RS08030	COG0559	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS08065	COG2814	Major facilitator Superfamily
IRT44_RS08070	COG0789	Transcriptional regulator
IRT44_RS08075	COG1414	Transcriptional regulator
IRT44_RS08085	COG3842	ATPase activity
IRT44_RS08090	COG1176	ABC-type spermidine putrescine transport system, permease component I
IRT44_RS08095	COG1177	transmembrane transport
IRT44_RS08100	COG2195	Cleaves the N-terminal amino acid of tripeptides
IRT44_RS08105	COG0683	leucine binding
IRT44_RS08110	COG2205	protein histidine kinase activity
IRT44_RS08110	COG2770	Histidine kinase
IRT44_RS08115	COG0745	RESPONSE REGULATOR receiver
IRT44_RS08120	COG1470	cell adhesion involved in biofilm formation
IRT44_RS08125	COG4496	protein, YerC YecD
IRT44_RS08130	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IRT44_RS08140	COG0584	glycerophosphoryl diester phosphodiesterase
IRT44_RS08150	COG0210	DNA helicase
IRT44_RS08155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IRT44_RS08170	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS08180	COG0688	phosphatidylethanolamine metabolic process
IRT44_RS08185	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IRT44_RS08190	COG0154	amidase activity
IRT44_RS08195	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IRT44_RS08210	COG4555	ABC transporter
IRT44_RS08215	COG1668	transmembrane transport
IRT44_RS08220	COG1940	carbohydrate kinase activity
IRT44_RS08225	COG1597	lipid kinase activity
IRT44_RS08230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IRT44_RS08240	COG3328	transposase activity
IRT44_RS08265	COG0827	DNA restriction-modification system
IRT44_RS08270	COG0827	DNA restriction-modification system
IRT44_RS08275	COG1024	Enoyl-CoA hydratase
IRT44_RS08280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRT44_RS08290	COG1609	Transcriptional regulator
IRT44_RS08295	COG3246	L-lysine catabolic process to acetate
IRT44_RS08300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IRT44_RS08305	COG2610	gluconate transmembrane transporter activity
IRT44_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_RS08315	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
IRT44_RS08325	COG5646	InterPro IPR014922
IRT44_RS08335	COG2207	Transcriptional regulator
IRT44_RS08345	COG0559	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS08365	COG0010	Belongs to the arginase family
IRT44_RS08370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IRT44_RS08375	COG1228	amidohydrolase
IRT44_RS08380	COG2207	Transcriptional regulator
IRT44_RS08380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_RS08385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_RS08390	COG2819	hydrolase of the alpha beta superfamily
IRT44_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_RS08400	COG1169	isochorismate synthase
IRT44_RS08405	COG1021	2,3-dihydroxybenzoate-AMP ligase
IRT44_RS08410	COG3433	isochorismatase activity
IRT44_RS08410	COG1535	isochorismatase
IRT44_RS08415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IRT44_RS08420	COG3251	PFAM MbtH domain protein
IRT44_RS08445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IRT44_RS08455	COG3773	Cell wall hydrolase
IRT44_RS08480	COG0501	Belongs to the peptidase M48B family
IRT44_RS08485	COG2259	Doxx family
IRT44_RS08490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_RS08500	COG1823	symporter activity
IRT44_RS08505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IRT44_RS08510	COG0583	DNA-binding transcription factor activity
IRT44_RS08515	COG1380	Effector of murein hydrolase LrgA
IRT44_RS08520	COG1346	cytolysis
IRT44_RS08535	COG0071	Belongs to the small heat shock protein (HSP20) family
IRT44_RS08550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IRT44_RS08555	COG1360	Flagellar Motor Protein
IRT44_RS08560	COG1733	regulation of RNA biosynthetic process
IRT44_RS08565	COG0693	protein deglycase activity
IRT44_RS08600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IRT44_RS08605	COG3852	Histidine kinase
IRT44_RS08610	COG2204	response regulator
IRT44_RS08615	COG2031	fatty acid transporter
IRT44_RS08620	COG1253	flavin adenine dinucleotide binding
IRT44_RS08660	COG0577	efflux transmembrane transporter activity
IRT44_RS08665	COG1136	(ABC) transporter
IRT44_RS08670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_RS08680	COG0166	Belongs to the GPI family
IRT44_RS08685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IRT44_RS08705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IRT44_RS08715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IRT44_RS08715	COG1199	ATP-dependent helicase activity
IRT44_RS08725	COG0004	ammonium transporteR
IRT44_RS08740	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IRT44_RS08755	COG2996	Protein conserved in bacteria
IRT44_RS08775	COG2358	TRAP transporter, solute receptor (TAXI family
IRT44_RS08780	COG4191	Histidine kinase
IRT44_RS08785	COG0784	Response regulator, receiver
IRT44_RS08815	COG2133	pyrroloquinoline quinone binding
IRT44_RS08830	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IRT44_RS08835	COG1114	Component of the transport system for branched-chain amino acids
IRT44_RS08840	COG0697	spore germination
IRT44_RS08845	COG0824	Thioesterase
IRT44_RS08855	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IRT44_RS08870	COG0745	RESPONSE REGULATOR receiver
IRT44_RS08875	COG2205	protein histidine kinase activity
IRT44_RS08880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_RS08895	COG1649	PFAM Uncharacterised BCR, COG1649
IRT44_RS08900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IRT44_RS08905	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IRT44_RS08915	COG0346	lactoylglutathione lyase activity
IRT44_RS08935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IRT44_RS08945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IRT44_RS08965	COG1268	BioY protein
IRT44_RS08975	COG5002	protein histidine kinase activity
IRT44_RS08980	COG0745	RESPONSE REGULATOR receiver
IRT44_RS08985	COG0791	NLP P60 protein
IRT44_RS08995	COG1842	Phage shock protein A
IRT44_RS09000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IRT44_RS09005	COG4758	membrane
IRT44_RS09010	COG4585	Histidine kinase
IRT44_RS09015	COG2197	response regulator
IRT44_RS09025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IRT44_RS09050	COG3384	dioxygenase
IRT44_RS09055	COG1988	membrane-bound metal-dependent
IRT44_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_RS09090	COG0456	acetyltransferase
IRT44_RS09095	COG3557	Belongs to the UPF0374 family
IRT44_RS09100	COG1132	(ABC) transporter
IRT44_RS09105	COG2814	Major facilitator Superfamily
IRT44_RS09110	COG2084	Dehydrogenase
IRT44_RS09115	COG2738	Putative neutral zinc metallopeptidase
IRT44_RS09120	COG0070	glutamate synthase
IRT44_RS09120	COG0069	glutamate synthase activity
IRT44_RS09120	COG0067	glutamate synthase
IRT44_RS09130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IRT44_RS09135	COG4555	ABC transporter
IRT44_RS09170	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IRT44_RS09175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IRT44_RS09180	COG0546	phosphoglycolate phosphatase activity
IRT44_RS09190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IRT44_RS09195	COG1363	Peptidase, m42
IRT44_RS09205	COG2096	Adenosyltransferase
IRT44_RS09215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_RS09220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IRT44_RS09225	COG0735	belongs to the Fur family
IRT44_RS09230	COG3858	chitin binding
IRT44_RS09335	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IRT44_RS09340	COG3189	MarR family transcriptional regulator
IRT44_RS09345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IRT44_RS09355	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IRT44_RS09360	COG1140	nitrate reductase beta subunit
IRT44_RS09365	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IRT44_RS09370	COG2181	nitrate reductase activity
IRT44_RS09375	COG2223	nitrite transmembrane transporter activity
IRT44_RS09385	COG0535	radical SAM domain protein
IRT44_RS09395	COG0303	'Molybdopterin
IRT44_RS09400	COG2233	PERMEase
IRT44_RS09405	COG3382	B3 4 domain protein
IRT44_RS09410	COG0328	RNA-DNA hybrid ribonuclease activity
IRT44_RS09420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IRT44_RS09435	COG0546	phosphoglycolate phosphatase activity
IRT44_RS09440	COG2766	serine protein kinase
IRT44_RS09445	COG2718	Belongs to the UPF0229 family
IRT44_RS09455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IRT44_RS09460	COG0438	transferase activity, transferring glycosyl groups
IRT44_RS09475	COG1482	cell wall glycoprotein biosynthetic process
IRT44_RS09485	COG3279	Response regulator of the LytR AlgR family
IRT44_RS09495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_RS09535	COG1522	sequence-specific DNA binding
IRT44_RS09540	COG0436	Aminotransferase
IRT44_RS09545	COG0833	amino acid
IRT44_RS09550	COG1840	ABC-type Fe3 transport system, periplasmic component
IRT44_RS09555	COG3842	ATPase activity
IRT44_RS09565	COG0647	UMP catabolic process
IRT44_RS09570	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IRT44_RS09575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IRT44_RS09625	COG2721	sulfolactate sulfo-lyase activity
IRT44_RS09630	COG2721	sulfolactate sulfo-lyase activity
IRT44_RS09695	COG0783	Belongs to the Dps family
IRT44_RS09700	COG0746	molybdenum cofactor guanylyltransferase activity
IRT44_RS09705	COG3344	reverse transcriptase
IRT44_RS09710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IRT44_RS09715	COG2223	nitrite transmembrane transporter activity
IRT44_RS09720	COG5609	conserved protein (DUF2294)
IRT44_RS09725	COG0303	'Molybdopterin
IRT44_RS09730	COG1763	Mo-molybdopterin cofactor biosynthetic process
IRT44_RS09740	COG1968	undecaprenyl-diphosphatase activity
IRT44_RS09745	COG2259	Doxx family
IRT44_RS09760	COG2363	Small membrane protein
IRT44_RS09770	COG2719	SpoVR family
IRT44_RS09775	COG0477	Major facilitator Superfamily
IRT44_RS09790	COG2807	transmembrane transport
IRT44_RS09795	COG0583	DNA-binding transcription factor activity
IRT44_RS09810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IRT44_RS09815	COG1845	cytochrome c oxidase, subunit III
IRT44_RS09825	COG0492	ferredoxin-NADP+ reductase activity
IRT44_RS09830	COG2814	Major facilitator Superfamily
IRT44_RS09840	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IRT44_RS09845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRT44_RS09855	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IRT44_RS09865	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IRT44_RS09890	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IRT44_RS09920	COG1492	cobalamin metabolic process
IRT44_RS09925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IRT44_RS09935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IRT44_RS09935	COG1648	precorrin-2 dehydrogenase activity
IRT44_RS09940	COG2204	response regulator
IRT44_RS09985	COG1802	Transcriptional regulator
IRT44_RS09990	COG0045	succinate-CoA ligase (ADP-forming) activity
IRT44_RS10005	COG2009	succinate dehydrogenase
IRT44_RS10010	COG1053	succinate dehydrogenase
IRT44_RS10015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IRT44_RS10035	COG2076	Multidrug Resistance protein
IRT44_RS10040	COG2076	Multidrug Resistance protein
IRT44_RS10045	COG0095	Lipoate-protein ligase
IRT44_RS10050	COG1301	dicarboxylic acid transport
IRT44_RS10055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IRT44_RS10060	COG3832	glyoxalase III activity
IRT44_RS10065	COG0640	Transcriptional regulator
IRT44_RS10070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IRT44_RS10075	COG3290	protein histidine kinase activity
IRT44_RS10080	COG4565	transcriptional regulatory protein
IRT44_RS10085	COG1619	proteins homologs of microcin C7 resistance protein MccF
IRT44_RS10090	COG0783	Belongs to the Dps family
IRT44_RS10095	COG1072	(Pantothenic acid kinase))
IRT44_RS10100	COG1683	Conserved Protein
IRT44_RS10105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IRT44_RS10110	COG1737	Transcriptional regulator
IRT44_RS10115	COG1070	Carbohydrate kinase
IRT44_RS10125	COG0583	DNA-binding transcription factor activity
IRT44_RS10155	COG0180	Tryptophanyl-tRNA synthetase
IRT44_RS10175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_RS10180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IRT44_RS10195	COG0402	S-adenosylhomocysteine deaminase activity
IRT44_RS10200	COG3328	transposase activity
IRT44_RS10215	COG1737	Transcriptional regulator
IRT44_RS10220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRT44_RS10225	COG1653	transport
IRT44_RS10230	COG1175	transmembrane transport
IRT44_RS10235	COG0395	ABC-type sugar transport system, permease component
IRT44_RS10240	COG2971	BadF BadG BcrA BcrD
IRT44_RS10255	COG3706	GGDEF domain
IRT44_RS10260	COG1757	Na H antiporter
IRT44_RS10285	COG1175	transmembrane transport
IRT44_RS10290	COG0395	ABC-type sugar transport system, permease component
IRT44_RS10295	COG0673	inositol 2-dehydrogenase activity
IRT44_RS10325	COG0492	ferredoxin-NADP+ reductase activity
IRT44_RS10335	COG0450	alkyl hydroperoxide reductase
IRT44_RS10355	COG0189	ligase activity
IRT44_RS10360	COG0189	ligase activity
IRT44_RS10365	COG0189	ligase activity
IRT44_RS10370	COG4399	Belongs to the UPF0754 family
IRT44_RS10375	COG4109	DRTGG domain
IRT44_RS10380	COG0640	Transcriptional regulator
IRT44_RS10395	COG0587	DNA-directed DNA polymerase activity
IRT44_RS10400	COG0281	malic enzyme
IRT44_RS10405	COG2186	Transcriptional regulator
IRT44_RS10415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IRT44_RS10420	COG0825	malonyl-CoA metabolic process
IRT44_RS10425	COG0205	6-phosphofructokinase activity
IRT44_RS10435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IRT44_RS10440	COG0824	Thioesterase
IRT44_RS10445	COG3030	protein affecting phage T7 exclusion by the F plasmid
IRT44_RS10450	COG0628	permease
IRT44_RS10460	COG0538	isocitrate dehydrogenase activity
IRT44_RS10465	COG0039	L-malate dehydrogenase activity
IRT44_RS10470	COG0745	RESPONSE REGULATOR receiver
IRT44_RS10475	COG5002	protein histidine kinase activity
IRT44_RS10480	COG0704	Plays a role in the regulation of phosphate uptake
IRT44_RS10490	COG2720	vancomycin resistance protein
IRT44_RS10495	COG1846	Transcriptional regulator
IRT44_RS10500	COG1566	PFAM secretion protein HlyD family protein
IRT44_RS10510	COG2814	Major facilitator Superfamily
IRT44_RS10530	COG2861	carbohydrate metabolic process
IRT44_RS10535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRT44_RS10535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IRT44_RS10540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IRT44_RS10545	COG0237	dephospho-CoA kinase activity
IRT44_RS10550	COG0741	lytic transglycosylase activity
IRT44_RS10550	COG0739	heme binding
IRT44_RS10550	COG1196	nuclear chromosome segregation
IRT44_RS10555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IRT44_RS10570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IRT44_RS10580	COG1484	DNA-dependent DNA replication
IRT44_RS10625	COG3973	AAA domain
IRT44_RS10635	COG0778	Nitroreductase
IRT44_RS10645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IRT44_RS10650	COG0747	negative chemotaxis
IRT44_RS10655	COG0601	transmembrane transport
IRT44_RS10660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_RS10665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRT44_RS10670	COG0444	Belongs to the ABC transporter superfamily
IRT44_RS10675	COG4608	Belongs to the ABC transporter superfamily
IRT44_RS10690	COG0247	lactate metabolic process
IRT44_RS10715	COG3773	Cell wall hydrolase
IRT44_RS10735	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IRT44_RS10745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IRT44_RS10750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IRT44_RS10755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IRT44_RS10760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IRT44_RS10765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IRT44_RS10770	COG0175	sulfate reduction
IRT44_RS10775	COG2046	Belongs to the sulfate adenylyltransferase family
IRT44_RS10780	COG0028	Belongs to the TPP enzyme family
IRT44_RS10785	COG0440	acetolactate synthase activity
IRT44_RS10790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IRT44_RS10795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_RS10815	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_RS10820	COG0521	Mo-molybdopterin cofactor biosynthetic process
IRT44_RS10825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRT44_RS10830	COG0586	Pfam SNARE associated Golgi protein
IRT44_RS10835	COG3326	Membrane
IRT44_RS10845	COG0569	domain protein
IRT44_RS10850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IRT44_RS10855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IRT44_RS10865	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IRT44_RS10870	COG1606	tRNA processing
IRT44_RS10875	COG1691	(AIR) carboxylase
IRT44_RS10885	COG1193	negative regulation of DNA recombination
IRT44_RS10890	COG3766	membrane
IRT44_RS10900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IRT44_RS10905	COG2851	Citrate transporter
IRT44_RS10910	COG3290	protein histidine kinase activity
IRT44_RS10915	COG4565	transcriptional regulatory protein
IRT44_RS10925	COG2362	D-Aminopeptidase
IRT44_RS10930	COG0438	transferase activity, transferring glycosyl groups
IRT44_RS10955	COG0728	peptidoglycan biosynthetic process
IRT44_RS10965	COG2244	polysaccharide biosynthetic process
IRT44_RS10970	COG2226	methyltransferase
IRT44_RS10980	COG2264	protein methyltransferase activity
IRT44_RS10985	COG0183	Belongs to the thiolase family
IRT44_RS10990	COG1316	TRANSCRIPTIONal
IRT44_RS10995	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_RS11000	COG1309	transcriptional regulator
IRT44_RS11005	COG1024	Enoyl-CoA hydratase
IRT44_RS11010	COG2086	electron transfer activity
IRT44_RS11015	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IRT44_RS11025	COG3118	belongs to the thioredoxin family
IRT44_RS11030	COG0322	excinuclease ABC activity
IRT44_RS11035	COG1794	racemase activity, acting on amino acids and derivatives
IRT44_RS11050	COG2009	succinate dehydrogenase
IRT44_RS11055	COG1053	succinate dehydrogenase
IRT44_RS11060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IRT44_RS11065	COG0477	Major facilitator Superfamily
IRT44_RS11070	COG1846	Transcriptional regulator
IRT44_RS11090	COG1406	Chemotaxis phosphatase CheX
IRT44_RS11100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_RS11105	COG2197	response regulator
IRT44_RS11110	COG3290	protein histidine kinase activity
IRT44_RS11110	COG3829	transcription factor binding
IRT44_RS11115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IRT44_RS11120	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS11125	COG1113	amino acid transport
IRT44_RS11140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IRT44_RS11145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_RS11145	COG3711	transcriptional antiterminator
IRT44_RS11150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRT44_RS11190	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IRT44_RS11195	COG1115	amino acid carrier protein
IRT44_RS11205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IRT44_RS11210	COG0644	oxidoreductase
IRT44_RS11240	COG1216	Glycosyl transferase, family 2
IRT44_RS11260	COG0463	Glycosyl transferase, family 2
IRT44_RS11270	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IRT44_RS11270	COG0662	Cupin 2, conserved barrel domain protein
IRT44_RS11275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_RS11285	COG1216	Glycosyl transferase, family 2
IRT44_RS11300	COG1216	Glycosyl transferase, family 2
IRT44_RS11335	COG4166	transmembrane transport
IRT44_RS11340	COG3290	protein histidine kinase activity
IRT44_RS11340	COG3829	transcription factor binding
IRT44_RS11345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_RS11350	COG0601	transmembrane transport
IRT44_RS11355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_RS11360	COG0444	Belongs to the ABC transporter superfamily
IRT44_RS11370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IRT44_RS11375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IRT44_RS11380	COG5401	PFAM Sporulation and spore germination
IRT44_RS11390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IRT44_RS11400	COG0622	Phosphoesterase
IRT44_RS11405	COG0544	peptidyl-prolyl cis-trans isomerase activity
IRT44_RS11410	COG0740	serine-type endopeptidase activity
IRT44_RS11415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IRT44_RS11420	COG0470	DNA polymerase III
IRT44_RS11420	COG1067	ATP-dependent peptidase activity
IRT44_RS11430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IRT44_RS11445	COG0840	transmembrane signaling receptor activity
IRT44_RS11450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IRT44_RS11455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IRT44_RS11460	COG0181	hydroxymethylbilane synthase activity
IRT44_RS11470	COG0113	porphobilinogen synthase activity
IRT44_RS11475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IRT44_RS11480	COG2801	Transposase and inactivated derivatives
IRT44_RS11505	COG0737	Belongs to the 5'-nucleotidase family
IRT44_RS11525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IRT44_RS11530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IRT44_RS11535	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IRT44_RS11540	COG1388	LysM domain
IRT44_RS11560	COG2208	phosphoserine phosphatase activity
IRT44_RS11575	COG0525	valine-tRNA ligase activity
IRT44_RS11580	COG0285	dihydrofolate synthase activity
IRT44_RS11585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IRT44_RS11590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRT44_RS11595	COG0475	glutathione-regulated potassium exporter activity
IRT44_RS11600	COG0490	domain, Protein
IRT44_RS11625	COG0424	maF-like protein
IRT44_RS11630	COG2003	Belongs to the UPF0758 family
IRT44_RS11635	COG1077	Cell shape determining protein MreB Mrl
IRT44_RS11640	COG1792	Involved in formation and maintenance of cell shape
IRT44_RS11645	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IRT44_RS11650	COG0768	penicillin binding
IRT44_RS11655	COG0850	regulation of cytokinetic process
IRT44_RS11660	COG2894	cell division
IRT44_RS11665	COG0772	Belongs to the SEDS family
IRT44_RS11680	COG1994	Peptidase M50
IRT44_RS11685	COG1530	ribonuclease E activity
IRT44_RS11690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IRT44_RS11695	COG2868	ribosomal protein
IRT44_RS11700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IRT44_RS11710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IRT44_RS11725	COG4492	Belongs to the UPF0735 family
IRT44_RS11730	COG0460	homoserine dehydrogenase
IRT44_RS11735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IRT44_RS11740	COG0083	homoserine kinase activity
IRT44_RS11745	COG0077	Prephenate dehydratase
IRT44_RS11785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IRT44_RS11790	COG0632	four-way junction helicase activity
IRT44_RS11795	COG2255	four-way junction helicase activity
IRT44_RS11810	COG2385	sporulation resulting in formation of a cellular spore
IRT44_RS11815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IRT44_RS11820	COG0343	queuine tRNA-ribosyltransferase activity
IRT44_RS11825	COG1862	Preprotein translocase
IRT44_RS11835	COG0598	Magnesium transport protein CorA
IRT44_RS11840	COG2323	membrane
IRT44_RS11845	COG2244	polysaccharide biosynthetic process
IRT44_RS11855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRT44_RS11855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRT44_RS11860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRT44_RS11860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IRT44_RS11865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IRT44_RS11870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IRT44_RS11870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IRT44_RS11875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IRT44_RS11880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IRT44_RS11885	COG1490	D-aminoacyl-tRNA deacylase activity
IRT44_RS11895	COG2267	carboxylic ester hydrolase activity
IRT44_RS11905	COG3103	Sh3 type 3 domain protein
IRT44_RS11905	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_RS11905	COG4991	sh3 domain protein
IRT44_RS11915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IRT44_RS11920	COG0124	histidyl-tRNA synthetase
IRT44_RS11925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IRT44_RS11935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IRT44_RS11945	COG1349	DNA-binding transcription factor activity
IRT44_RS11950	COG0673	inositol 2-dehydrogenase activity
IRT44_RS11965	COG1959	2 iron, 2 sulfur cluster binding
IRT44_RS11970	COG1104	cysteine desulfurase activity
IRT44_RS11975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IRT44_RS11995	COG0861	Integral membrane protein TerC family
IRT44_RS12000	COG0628	permease
IRT44_RS12005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IRT44_RS12010	COG4472	Bacterial protein of unknown function (DUF965)
IRT44_RS12015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IRT44_RS12020	COG3906	Belongs to the UPF0473 family
IRT44_RS12025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IRT44_RS12030	COG4122	O-methyltransferase activity
IRT44_RS12040	COG3344	reverse transcriptase
IRT44_RS12045	COG0768	penicillin binding
IRT44_RS12060	COG1349	DNA-binding transcription factor activity
IRT44_RS12065	COG1069	ribulokinase activity
IRT44_RS12070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_RS12080	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS12085	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS12105	COG2801	Transposase and inactivated derivatives
IRT44_RS12120	COG1414	Transcriptional regulator
IRT44_RS12125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRT44_RS12135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IRT44_RS12145	COG1131	(ABC) transporter
IRT44_RS12155	COG1131	(ABC) transporter
IRT44_RS12160	COG1725	Transcriptional regulator
IRT44_RS12180	COG1611	Belongs to the LOG family
IRT44_RS12205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_RS12210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IRT44_RS12215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IRT44_RS12220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IRT44_RS12235	COG0010	Belongs to the arginase family
IRT44_RS12245	COG0488	(ABC) transporter
IRT44_RS12250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IRT44_RS12255	COG3191	aminopeptidase activity
IRT44_RS12265	COG1413	lyase activity
IRT44_RS12270	COG1233	COG1233 Phytoene dehydrogenase and related
IRT44_RS12280	COG4166	transmembrane transport
IRT44_RS12285	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IRT44_RS12290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IRT44_RS12295	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IRT44_RS12300	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IRT44_RS12305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IRT44_RS12310	COG1534	Rna-binding protein
IRT44_RS12315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IRT44_RS12320	COG1713	HD superfamily hydrolase involved in NAD metabolism
IRT44_RS12325	COG0799	negative regulation of ribosome biogenesis
IRT44_RS12330	COG2226	methyltransferase
IRT44_RS12335	COG0495	leucyl-tRNA aminoacylation
IRT44_RS12340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IRT44_RS12345	COG1555	photosystem II stabilization
IRT44_RS12345	COG1596	polysaccharide export
IRT44_RS12350	COG0367	asparagine synthase
IRT44_RS12355	COG2131	deaminase
IRT44_RS12360	COG0658	competence protein
IRT44_RS12360	COG2333	competence protein COMEC
IRT44_RS12365	COG1595	DNA-templated transcription, initiation
IRT44_RS12380	COG0268	Binds directly to 16S ribosomal RNA
IRT44_RS12390	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_RS12400	COG0444	Belongs to the ABC transporter superfamily
IRT44_RS12405	COG4608	Belongs to the ABC transporter superfamily
IRT44_RS12410	COG0747	negative chemotaxis
IRT44_RS12415	COG0601	transmembrane transport
IRT44_RS12420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_RS12425	COG0006	proline dipeptidase activity
IRT44_RS12445	COG0481	GTPase activity
IRT44_RS12450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IRT44_RS12455	COG1420	regulation of RNA biosynthetic process
IRT44_RS12465	COG0443	Heat shock 70 kDa protein
IRT44_RS12475	COG2264	protein methyltransferase activity
IRT44_RS12480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IRT44_RS12485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRT44_RS12495	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IRT44_RS12500	COG1380	Effector of murein hydrolase LrgA
IRT44_RS12505	COG1346	cytolysis
IRT44_RS12510	COG1283	sodium-dependent phosphate transmembrane transporter activity
IRT44_RS12530	COG1181	Belongs to the D-alanine--D-alanine ligase family
IRT44_RS12535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IRT44_RS12540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IRT44_RS12545	COG1610	YqeY-like protein
IRT44_RS12550	COG1030	water channel activity
IRT44_RS12555	COG4864	UPF0365 protein
IRT44_RS12580	COG1702	phosphate starvation-inducible protein PhoH
IRT44_RS12585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IRT44_RS12595	COG0295	cytidine deaminase activity
IRT44_RS12600	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IRT44_RS12610	COG1381	Involved in DNA repair and RecF pathway recombination
IRT44_RS12615	COG0752	glycyl-tRNA synthetase alpha subunit
IRT44_RS12620	COG0751	glycine-tRNA ligase activity
IRT44_RS12625	COG0517	IMP dehydrogenase activity
IRT44_RS12630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IRT44_RS12635	COG0358	DNA primase activity
IRT44_RS12640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IRT44_RS12655	COG1960	acyl-CoA dehydrogenase activity
IRT44_RS12660	COG2384	SAM-dependent methyltransferase
IRT44_RS12665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IRT44_RS12675	COG0793	Belongs to the peptidase S41A family
IRT44_RS12675	COG3409	Peptidoglycan-binding domain 1 protein
IRT44_RS12685	COG2801	Transposase and inactivated derivatives
IRT44_RS12695	COG3568	Endonuclease Exonuclease Phosphatase
IRT44_RS12760	COG1242	4 iron, 4 sulfur cluster binding
IRT44_RS12765	COG0584	glycerophosphoryl diester phosphodiesterase
IRT44_RS12770	COG0584	glycerophosphoryl diester phosphodiesterase
IRT44_RS12780	COG0456	acetyltransferase
IRT44_RS12790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IRT44_RS12795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IRT44_RS12800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IRT44_RS12805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_RS12810	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS12855	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_RS12865	COG3876	Protein conserved in bacteria
IRT44_RS12875	COG1309	transcriptional regulator
IRT44_RS12895	COG2249	NAD(P)H dehydrogenase (quinone) activity
IRT44_RS12905	COG0561	phosphatase activity
IRT44_RS12910	COG3842	ATPase activity
IRT44_RS12920	COG1408	metallophosphoesterase
IRT44_RS12925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IRT44_RS12935	COG2072	flavoprotein involved in K transport
IRT44_RS12945	COG2197	response regulator
IRT44_RS12950	COG3850	Histidine kinase
IRT44_RS12955	COG0351	phosphomethylpyrimidine kinase
IRT44_RS12965	COG1595	DNA-templated transcription, initiation
IRT44_RS12975	COG1428	Deoxynucleoside kinase
IRT44_RS12980	COG1428	Deoxynucleoside kinase
IRT44_RS12990	COG2154	pterin-4-alpha-carbinolamine dehydratase
IRT44_RS13000	COG1607	acyl-coa hydrolase
IRT44_RS13005	COG3011	Protein conserved in bacteria
IRT44_RS13025	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS13035	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_RS13075	COG1119	ATPase activity
IRT44_RS13095	COG1368	sulfuric ester hydrolase activity
IRT44_RS13110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRT44_RS13130	COG0535	radical SAM domain protein
IRT44_RS13140	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IRT44_RS13145	COG0316	Belongs to the HesB IscA family
IRT44_RS13160	COG0367	asparagine synthase
IRT44_RS13165	COG3275	phosphorelay sensor kinase activity
IRT44_RS13170	COG3279	Response regulator of the LytR AlgR family
IRT44_RS13175	COG3162	membrane
IRT44_RS13180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_RS13185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_RS13190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IRT44_RS13200	COG0018	arginyl-trna synthetase
IRT44_RS13215	COG0646	methionine synthase
IRT44_RS13215	COG1410	methionine synthase
IRT44_RS13220	COG0646	methionine synthase
IRT44_RS13220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IRT44_RS13225	COG3663	DNA glycosylase
IRT44_RS13230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IRT44_RS13235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IRT44_RS13280	COG0612	Peptidase, M16
IRT44_RS13305	COG3279	Response regulator of the LytR AlgR family
IRT44_RS13345	COG3739	integral membrane protein
IRT44_RS13350	COG3655	Transcriptional regulator
IRT44_RS13370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRT44_RS13375	COG1116	anion transmembrane transporter activity
IRT44_RS13380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRT44_RS13385	COG1234	tRNA 3'-trailer cleavage
IRT44_RS13405	COG1404	Belongs to the peptidase S8 family
IRT44_RS13415	COG1671	Belongs to the UPF0178 family
IRT44_RS13420	COG0583	DNA-binding transcription factor activity
IRT44_RS13430	COG0833	amino acid
IRT44_RS13435	COG3829	transcription factor binding
IRT44_RS13440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRT44_RS13450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IRT44_RS13460	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IRT44_RS13465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IRT44_RS13470	COG4838	Belongs to the UPF0358 family
IRT44_RS13475	COG0733	neurotransmitter:sodium symporter activity
IRT44_RS13485	COG0346	lactoylglutathione lyase activity
IRT44_RS13490	COG0387	Pfam Sodium calcium exchanger
IRT44_RS13505	COG0028	Belongs to the TPP enzyme family
IRT44_RS13515	COG0772	Belongs to the SEDS family
IRT44_RS13525	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IRT44_RS13530	COG2226	methyltransferase
IRT44_RS13535	COG1525	nuclease
IRT44_RS13555	COG3679	Belongs to the UPF0342 family
IRT44_RS13565	COG4471	UPF0298 protein
IRT44_RS13570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IRT44_RS13580	COG4149	molybdate abc transporter
IRT44_RS13585	COG0725	ABC transporter, periplasmic molybdate-binding protein
IRT44_RS13590	COG1910	domain protein
IRT44_RS13600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IRT44_RS13625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IRT44_RS13635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IRT44_RS13640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IRT44_RS13645	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IRT44_RS13650	COG0095	Lipoate-protein ligase
IRT44_RS13655	COG1846	Transcriptional regulator
IRT44_RS13660	COG2814	Major facilitator Superfamily
IRT44_RS13675	COG5002	protein histidine kinase activity
IRT44_RS13685	COG0431	NADPH-dependent FMN reductase
IRT44_RS13690	COG1321	iron dependent repressor
IRT44_RS13695	COG1752	Esterase of the alpha-beta hydrolase superfamily
IRT44_RS13705	COG3872	metal-dependent enzyme
IRT44_RS13715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IRT44_RS13720	COG0006	proline dipeptidase activity
IRT44_RS13725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IRT44_RS13730	COG2707	UPF0756 membrane protein
IRT44_RS13735	COG2045	Belongs to the ComB family
IRT44_RS13740	COG1809	phosphosulfolactate synthase activity
IRT44_RS13755	COG3854	ATPases associated with a variety of cellular activities
IRT44_RS13795	COG0511	ligase activity, forming carbon-carbon bonds
IRT44_RS13800	COG0439	Biotin carboxylase
IRT44_RS13805	COG1302	Protein conserved in bacteria
IRT44_RS13820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRT44_RS13830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IRT44_RS13835	COG1570	exodeoxyribonuclease VII activity
IRT44_RS13850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IRT44_RS13855	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IRT44_RS13860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IRT44_RS13865	COG1438	arginine binding
IRT44_RS13870	COG0497	DNA recombination
IRT44_RS13875	COG0750	zinc metalloprotease
IRT44_RS13885	COG2172	sigma factor antagonist activity
IRT44_RS13890	COG4191	Histidine kinase
IRT44_RS13895	COG0288	reversible hydration of carbon dioxide
IRT44_RS13900	COG1408	metallophosphoesterase
IRT44_RS13905	COG0583	DNA-binding transcription factor activity
IRT44_RS13915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IRT44_RS13935	COG0463	Glycosyl transferase, family 2
IRT44_RS13950	COG3290	protein histidine kinase activity
IRT44_RS13950	COG3829	transcription factor binding
IRT44_RS13955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRT44_RS13960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IRT44_RS13965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IRT44_RS13970	COG0022	dehydrogenase e1 component
IRT44_RS13975	COG0508	dehydrogenase complex catalyzes the overall conversion of
IRT44_RS13985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRT44_RS13985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IRT44_RS13990	COG0346	lactoylglutathione lyase activity
IRT44_RS13995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IRT44_RS14000	COG2195	Cleaves the N-terminal amino acid of tripeptides
IRT44_RS14020	COG1300	Membrane
IRT44_RS14025	COG0735	belongs to the Fur family
IRT44_RS14030	COG0686	Belongs to the AlaDH PNT family
IRT44_RS14040	COG4974	Belongs to the 'phage' integrase family
IRT44_RS14045	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IRT44_RS14055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IRT44_RS14065	COG4166	transmembrane transport
IRT44_RS14070	COG0601	transmembrane transport
IRT44_RS14075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IRT44_RS14080	COG0444	Belongs to the ABC transporter superfamily
IRT44_RS14085	COG4608	Belongs to the ABC transporter superfamily
IRT44_RS14090	COG0840	transmembrane signaling receptor activity
IRT44_RS14095	COG1686	Belongs to the peptidase S11 family
IRT44_RS14105	COG2172	sigma factor antagonist activity
IRT44_RS14130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRT44_RS14145	COG0697	spore germination
IRT44_RS14150	COG0019	diaminopimelate decarboxylase activity
IRT44_RS14155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IRT44_RS14160	COG1994	Peptidase M50
IRT44_RS14165	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IRT44_RS14170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IRT44_RS14175	COG1686	Belongs to the peptidase S11 family
IRT44_RS14180	COG2715	membrane protein required for spore maturation
IRT44_RS14185	COG0700	Nucleoside recognition
IRT44_RS14190	COG1187	pseudouridine synthase activity
IRT44_RS14195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_RS14200	COG1333	cytochrome c biogenesis protein
IRT44_RS14205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IRT44_RS14210	COG0745	RESPONSE REGULATOR receiver
IRT44_RS14215	COG5002	protein histidine kinase activity
IRT44_RS14220	COG0546	phosphoglycolate phosphatase activity
IRT44_RS14230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IRT44_RS14255	COG4955	Helix-turn-helix domain
IRT44_RS14260	COG0514	ATP-dependent DNA helicase (RecQ)
IRT44_RS14285	COG4862	establishment of competence for transformation
IRT44_RS14290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRT44_RS14295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRT44_RS14300	COG0252	asparaginase activity
IRT44_RS14305	COG2339	peptidase activity
IRT44_RS14330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IRT44_RS14335	COG2937	Belongs to the GPAT DAPAT family
IRT44_RS14340	COG0539	negative regulation of cytoplasmic translation
IRT44_RS14345	COG1304	FMN binding
IRT44_RS14365	COG1160	GTP binding
IRT44_RS14370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IRT44_RS14375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IRT44_RS14410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IRT44_RS14420	COG0302	gtp cyclohydrolase
IRT44_RS14435	COG0741	lytic transglycosylase activity
IRT44_RS14450	COG0142	geranyltranstransferase activity
IRT44_RS14460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IRT44_RS14465	COG0163	prenyltransferase activity
IRT44_RS14480	COG0105	UTP biosynthetic process
IRT44_RS14485	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IRT44_RS14495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IRT44_RS14500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IRT44_RS14505	COG4401	Chorismate mutase type I
IRT44_RS14515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IRT44_RS14520	COG0134	indole-3-glycerol-phosphate synthase activity
IRT44_RS14525	COG0135	phosphoribosylanthranilate isomerase activity
IRT44_RS14535	COG0159	tryptophan synthase activity
IRT44_RS14540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IRT44_RS14550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IRT44_RS14555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRT44_RS14615	COG0069	glutamate synthase activity
IRT44_RS14620	COG3361	conserved protein (COG2071)
IRT44_RS14625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_RS14630	COG1694	Mazg nucleotide pyrophosphohydrolase
IRT44_RS14635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IRT44_RS14640	COG1803	Methylglyoxal synthase
IRT44_RS14645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IRT44_RS14650	COG0438	transferase activity, transferring glycosyl groups
IRT44_RS14665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IRT44_RS14670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IRT44_RS14675	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IRT44_RS14685	COG1199	ATP-dependent helicase activity
IRT44_RS14685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IRT44_RS14695	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IRT44_RS14700	COG0402	S-adenosylhomocysteine deaminase activity
IRT44_RS14725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IRT44_RS14735	COG0017	Asparaginyl-tRNA synthetase
IRT44_RS14740	COG3935	DnaD domain protein
IRT44_RS14760	COG1215	transferase activity, transferring glycosyl groups
IRT44_RS14765	COG0438	transferase activity, transferring glycosyl groups
IRT44_RS14775	COG1164	Oligoendopeptidase f
IRT44_RS14780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_RS14790	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_RS14795	COG1666	GTP binding
IRT44_RS14805	COG0318	PFAM AMP-dependent synthetase and ligase
IRT44_RS14810	COG0066	3-isopropylmalate dehydratase activity
IRT44_RS14815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IRT44_RS14820	COG0583	DNA-binding transcription factor activity
IRT44_RS14825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_RS14830	COG0564	pseudouridine synthase activity
IRT44_RS14835	COG0189	ligase activity
IRT44_RS14860	COG5002	protein histidine kinase activity
IRT44_RS14865	COG1054	Belongs to the UPF0176 family
IRT44_RS14890	COG0756	dUTP diphosphatase activity
IRT44_RS14895	COG2258	MOSC domain
IRT44_RS14900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IRT44_RS14905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IRT44_RS14910	COG4208	sulfate ABC transporter
IRT44_RS14920	COG0488	(ABC) transporter
IRT44_RS14925	COG2508	Transcriptional regulator
IRT44_RS14935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IRT44_RS14950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IRT44_RS14950	COG3153	acetyltransferase
IRT44_RS14970	COG3290	protein histidine kinase activity
IRT44_RS14970	COG3829	transcription factor binding
IRT44_RS14975	COG0473	3-isopropylmalate dehydrogenase activity
IRT44_RS14980	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS14990	COG1122	ATPase activity
IRT44_RS14995	COG1122	ATPase activity
IRT44_RS15000	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IRT44_RS15005	COG4684	Psort location CytoplasmicMembrane, score
IRT44_RS15010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_RS15040	COG1215	transferase activity, transferring glycosyl groups
IRT44_RS15045	COG0745	RESPONSE REGULATOR receiver
IRT44_RS15060	COG0791	NLP P60 protein
IRT44_RS15060	COG1388	LysM domain
IRT44_RS15095	COG0791	NLP P60 protein
IRT44_RS15115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_RS15125	COG0492	ferredoxin-NADP+ reductase activity
IRT44_RS15130	COG0537	adenosine 5'-monophosphoramidase activity
IRT44_RS15135	COG3383	formate dehydrogenase (NAD+) activity
IRT44_RS15140	COG2427	Protein of unknown function (DUF1641)
IRT44_RS15145	COG5609	conserved protein (DUF2294)
IRT44_RS15150	COG3876	Protein conserved in bacteria
IRT44_RS15155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IRT44_RS15160	COG1472	Belongs to the glycosyl hydrolase 3 family
IRT44_RS15170	COG0527	aspartate kinase activity
IRT44_RS15185	COG0813	purine-nucleoside phosphorylase activity
IRT44_RS15200	COG1686	Belongs to the peptidase S11 family
IRT44_RS15205	COG2357	RelA SpoT domain protein
IRT44_RS15230	COG0714	Associated with various cellular activities
IRT44_RS15240	COG3069	C4-dicarboxylate transmembrane transporter activity
IRT44_RS15260	COG1113	amino acid transport
IRT44_RS15280	COG2340	Cysteine-rich secretory protein family
IRT44_RS15285	COG0242	peptide deformylase activity
IRT44_RS15295	COG2364	Membrane
IRT44_RS15300	COG1846	Transcriptional regulator
IRT44_RS15310	COG2311	Membrane
IRT44_RS15315	COG1114	Component of the transport system for branched-chain amino acids
IRT44_RS15325	COG2233	PERMEase
IRT44_RS15330	COG4336	lyase activity
IRT44_RS15340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IRT44_RS15345	COG1984	allophanate hydrolase subunit 2
IRT44_RS15350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IRT44_RS15360	COG2027	D-alanyl-D-alanine carboxypeptidase
IRT44_RS15370	COG0438	transferase activity, transferring glycosyl groups
IRT44_RS15375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IRT44_RS15380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IRT44_RS15385	COG1116	anion transmembrane transporter activity
IRT44_RS15390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IRT44_RS15395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_RS15400	COG2022	thiamine diphosphate biosynthetic process
IRT44_RS15405	COG2104	thiamine diphosphate biosynthetic process
IRT44_RS15415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IRT44_RS15425	COG1388	LysM domain
IRT44_RS15425	COG3858	chitin binding
IRT44_RS15435	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS15450	COG0482	sulfurtransferase activity
IRT44_RS15465	COG1361	Conserved repeat domain
IRT44_RS15465	COG2911	Protein conserved in bacteria
IRT44_RS15465	COG3266	domain, Protein
IRT44_RS15540	COG2843	Capsule synthesis protein
IRT44_RS15545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IRT44_RS15550	COG0785	Cytochrome C biogenesis protein
IRT44_RS15555	COG3852	Histidine kinase
IRT44_RS15560	COG3186	Phenylalanine-4-hydroxylase
IRT44_RS15570	COG0352	thiamine-phosphate diphosphorylase activity
IRT44_RS15575	COG0352	thiamine-phosphate diphosphorylase activity
IRT44_RS15610	COG4565	transcriptional regulatory protein
IRT44_RS15615	COG3290	protein histidine kinase activity
IRT44_RS15620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IRT44_RS15625	COG1953	Uracil, thiamine, allantoin
IRT44_RS15630	COG0840	transmembrane signaling receptor activity
IRT44_RS15660	COG0493	'glutamate synthase
IRT44_RS15680	COG2207	Transcriptional regulator
IRT44_RS15680	COG3708	Transcriptional regulator
IRT44_RS15685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IRT44_RS15690	COG1012	belongs to the aldehyde dehydrogenase family
IRT44_RS15710	COG0464	growth
IRT44_RS15725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IRT44_RS15730	COG0187	DNA topoisomerase II activity
IRT44_RS15735	COG0217	transcriptional regulatory protein
IRT44_RS15760	COG5002	protein histidine kinase activity
IRT44_RS15765	COG1090	epimerase
IRT44_RS15800	COG1595	DNA-templated transcription, initiation
IRT44_RS15805	COG0626	cystathionine gamma-synthase activity
IRT44_RS15810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IRT44_RS15815	COG3409	Peptidoglycan-binding domain 1 protein
IRT44_RS15815	COG3773	Cell wall hydrolase
IRT44_RS15825	COG2707	UPF0756 membrane protein
IRT44_RS15850	COG4848	Belongs to the UPF0354 family
IRT44_RS15860	COG0515	serine threonine protein kinase
IRT44_RS15880	COG4632	Exopolysaccharide biosynthesis protein
IRT44_RS15880	COG5434	Belongs to the glycosyl hydrolase 28 family
IRT44_RS15935	COG0531	amino acid
IRT44_RS15945	COG0316	Belongs to the HesB IscA family
IRT44_RS15950	COG3973	AAA domain
IRT44_RS15955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IRT44_RS15960	COG4224	UPF0291 protein
IRT44_RS15970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IRT44_RS15990	COG0174	glutamine synthetase
IRT44_RS15995	COG0789	Transcriptional regulator
IRT44_RS16000	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IRT44_RS16005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IRT44_RS16010	COG0464	growth
IRT44_RS16020	COG1923	regulation of RNA biosynthetic process
IRT44_RS16025	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IRT44_RS16030	COG2136	Putative SAM-dependent methyltransferase
IRT44_RS16030	COG2521	methyltransferase
IRT44_RS16035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IRT44_RS16040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IRT44_RS16055	COG4550	Control of competence regulator ComK, YlbF/YmcA
IRT44_RS16060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRT44_RS16065	COG1361	Conserved repeat domain
IRT44_RS16070	COG0095	Lipoate-protein ligase
IRT44_RS16080	COG0517	IMP dehydrogenase activity
IRT44_RS16090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IRT44_RS16095	COG1234	tRNA 3'-trailer cleavage
IRT44_RS16100	COG3949	Membrane
IRT44_RS16105	COG1013	pyruvate-flavodoxin oxidoreductase activity
IRT44_RS16110	COG0674	pyruvate-flavodoxin oxidoreductase activity
IRT44_RS16110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IRT44_RS16120	COG2359	stage V sporulation protein S
IRT44_RS16125	COG1692	metallophosphoesterase
IRT44_RS16130	COG3344	reverse transcriptase
IRT44_RS16140	COG2137	regulation of response to DNA damage stimulus
IRT44_RS16145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IRT44_RS16150	COG0513	Belongs to the DEAD box helicase family
IRT44_RS16160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IRT44_RS16165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IRT44_RS16170	COG1426	Protein conserved in bacteria
IRT44_RS16185	COG0300	oxidoreductase activity
IRT44_RS16190	COG0612	Peptidase, M16
IRT44_RS16195	COG0612	Peptidase, M16
IRT44_RS16205	COG1079	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS16210	COG4603	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS16215	COG3845	ABC transporter
IRT44_RS16220	COG1744	ABC transporter substrate-binding protein PnrA-like
IRT44_RS16225	COG2188	Transcriptional regulator
IRT44_RS16240	COG0740	serine-type endopeptidase activity
IRT44_RS16250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IRT44_RS16255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IRT44_RS16260	COG0527	aspartate kinase activity
IRT44_RS16265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IRT44_RS16270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IRT44_RS16275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRT44_RS16280	COG1873	PFAM PRC-barrel domain
IRT44_RS16285	COG0612	Peptidase, M16
IRT44_RS16290	COG0726	polysaccharide deacetylase
IRT44_RS16295	COG1185	polyribonucleotide nucleotidyltransferase activity
IRT44_RS16300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IRT44_RS16305	COG0196	riboflavin kinase activity
IRT44_RS16310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IRT44_RS16315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IRT44_RS16320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IRT44_RS16330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IRT44_RS16335	COG1358	cellular component organization or biogenesis
IRT44_RS16340	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IRT44_RS16345	COG0195	Participates in both transcription termination and antitermination
IRT44_RS16350	COG0779	Required for maturation of 30S ribosomal subunits
IRT44_RS16355	COG2176	DNA-directed DNA polymerase activity
IRT44_RS16360	COG0442	prolyl-tRNA aminoacylation
IRT44_RS16365	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IRT44_RS16370	COG0750	zinc metalloprotease
IRT44_RS16375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IRT44_RS16380	COG4589	Belongs to the CDS family
IRT44_RS16385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IRT44_RS16390	COG0233	cytoplasmic translational termination
IRT44_RS16395	COG0528	UMP kinase activity
IRT44_RS16400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IRT44_RS16405	COG0052	Belongs to the universal ribosomal protein uS2 family
IRT44_RS16430	COG1191	sigma factor activity
IRT44_RS16440	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IRT44_RS16445	COG1776	CheC inhibitor of MCP methylation
IRT44_RS16450	COG0835	chemotaxis
IRT44_RS16455	COG0643	Histidine kinase
IRT44_RS16455	COG2198	Histidine kinase
IRT44_RS16460	COG2201	protein-glutamate methylesterase activity
IRT44_RS16465	COG0455	bacterial-type flagellum organization
IRT44_RS16470	COG1419	protein localization to endoplasmic reticulum
IRT44_RS16475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRT44_RS16480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IRT44_RS16485	COG1684	flagellar biosynthetic protein fliR
IRT44_RS16490	COG1987	bacterial-type flagellum assembly
IRT44_RS16500	COG3190	flagellar
IRT44_RS16505	COG2201	protein-glutamate methylesterase activity
IRT44_RS16510	COG1776	CheC inhibitor of MCP methylation
IRT44_RS16510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRT44_RS16515	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRT44_RS16530	COG4786	Flagellar basal body rod
IRT44_RS16550	COG2882	bacterial-type flagellum organization
IRT44_RS16555	COG1157	protein secretion by the type III secretion system
IRT44_RS16565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IRT44_RS16570	COG1766	The M ring may be actively involved in energy transduction
IRT44_RS16575	COG1677	Flagellar hook-basal body complex protein FliE
IRT44_RS16580	COG1558	bacterial-type flagellum-dependent cell motility
IRT44_RS16585	COG1815	bacterial-type flagellum-dependent cell motility
IRT44_RS16590	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IRT44_RS16595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IRT44_RS16600	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IRT44_RS16605	COG4974	Belongs to the 'phage' integrase family
IRT44_RS16610	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IRT44_RS16615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IRT44_RS16620	COG0758	DNA mediated transformation
IRT44_RS16625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IRT44_RS16630	COG0045	succinate-CoA ligase (ADP-forming) activity
IRT44_RS16640	COG0393	Putative heavy-metal-binding
IRT44_RS16650	COG1737	Transcriptional regulator
IRT44_RS16660	COG0789	Transcriptional regulator
IRT44_RS16665	COG1664	Polymer-forming cytoskeletal
IRT44_RS16680	COG1414	Transcriptional regulator
IRT44_RS16705	COG0129	dihydroxy-acid dehydratase activity
IRT44_RS16710	COG4948	Mandelate Racemase Muconate Lactonizing
IRT44_RS16720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IRT44_RS16725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IRT44_RS16730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IRT44_RS16735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IRT44_RS16740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IRT44_RS16745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IRT44_RS16750	COG2271	Major facilitator Superfamily
IRT44_RS16755	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IRT44_RS16755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IRT44_RS16760	COG1864	DNA RNA non-specific endonuclease
IRT44_RS16760	COG3591	Belongs to the peptidase S1B family
IRT44_RS16785	COG2329	Antibiotic biosynthesis monooxygenase
IRT44_RS16790	COG2819	hydrolase of the alpha beta superfamily
IRT44_RS16795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS16800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS16805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_RS16810	COG0860	N-Acetylmuramoyl-L-alanine amidase
IRT44_RS16830	COG0243	molybdopterin cofactor binding
IRT44_RS16835	COG0697	spore germination
IRT44_RS16840	COG1620	l-lactate permease
IRT44_RS16850	COG0247	lactate metabolic process
IRT44_RS16855	COG0277	FAD linked oxidase domain protein
IRT44_RS16860	COG2186	Transcriptional regulator
IRT44_RS16865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IRT44_RS16945	COG0312	modulator of DNA gyrase
IRT44_RS16980	COG2207	Transcriptional regulator
IRT44_RS16980	COG3708	Transcriptional regulator
IRT44_RS16985	COG0662	Cupin 2, conserved barrel domain protein
IRT44_RS16990	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IRT44_RS16995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IRT44_RS17030	COG1280	lysine exporter protein (LysE YggA)
IRT44_RS17040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IRT44_RS17050	COG0488	(ABC) transporter
IRT44_RS17050	COG0488	(ABC) transporter
IRT44_RS17060	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IRT44_RS17090	COG0531	amino acid
IRT44_RS17095	COG2169	Transcriptional regulator
IRT44_RS17105	COG3328	transposase activity
IRT44_RS17110	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IRT44_RS17135	COG2135	peptidase activity
IRT44_RS17140	COG0024	Methionine aminopeptidase
IRT44_RS17145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_RS17150	COG1621	beta-fructofuranosidase activity
IRT44_RS17155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IRT44_RS17155	COG1263	PTS System
IRT44_RS17160	COG1609	Transcriptional regulator
IRT44_RS17170	COG2814	Major facilitator Superfamily
IRT44_RS17175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IRT44_RS17190	COG5322	oxidoreductase activity
IRT44_RS17190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRT44_RS17245	COG2207	Transcriptional regulator
IRT44_RS17245	COG3708	Transcriptional regulator
IRT44_RS17250	COG2132	Multicopper oxidase
IRT44_RS17255	COG2205	protein histidine kinase activity
IRT44_RS17260	COG0745	RESPONSE REGULATOR receiver
IRT44_RS17265	COG0477	Major facilitator Superfamily
IRT44_RS17275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRT44_RS17275	COG2755	lipolytic protein G-D-S-L family
IRT44_RS17280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IRT44_RS17280	COG2755	lipolytic protein G-D-S-L family
IRT44_RS17285	COG0583	DNA-binding transcription factor activity
IRT44_RS17310	COG0583	DNA-binding transcription factor activity
IRT44_RS17320	COG0436	Aminotransferase
IRT44_RS17325	COG1937	Protein conserved in bacteria
IRT44_RS17330	COG2210	Belongs to the sulfur carrier protein TusA family
IRT44_RS17335	COG0425	Belongs to the sulfur carrier protein TusA family
IRT44_RS17340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRT44_RS17340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_RS17345	COG0425	Belongs to the sulfur carrier protein TusA family
IRT44_RS17345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IRT44_RS17350	COG0730	response to heat
IRT44_RS17380	COG2151	metal-sulfur cluster biosynthetic enzyme
IRT44_RS17390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IRT44_RS17410	COG0606	chelatase, subunit chli
IRT44_RS17420	COG2257	FlhB HrpN YscU SpaS Family
IRT44_RS17430	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IRT44_RS17440	COG0681	Belongs to the peptidase S26 family
IRT44_RS17445	COG0335	large ribosomal subunit rRNA binding
IRT44_RS17450	COG0336	Belongs to the RNA methyltransferase TrmD family
IRT44_RS17455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IRT44_RS17465	COG1837	Belongs to the UPF0109 family
IRT44_RS17470	COG0228	four-way junction DNA binding
IRT44_RS17475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IRT44_RS17480	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IRT44_RS17530	COG0552	protein localization to endoplasmic reticulum
IRT44_RS17535	COG1196	nuclear chromosome segregation
IRT44_RS17545	COG0531	amino acid
IRT44_RS17555	COG3829	transcription factor binding
IRT44_RS17565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IRT44_RS17570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IRT44_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
IRT44_RS17580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IRT44_RS17585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IRT44_RS17590	COG0416	fatty acid biosynthetic process
IRT44_RS17595	COG2050	protein possibly involved in aromatic compounds catabolism
IRT44_RS17595	COG1349	DNA-binding transcription factor activity
IRT44_RS17600	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IRT44_RS17610	COG3480	Lon protease (S16) C-terminal proteolytic domain
IRT44_RS17615	COG1752	Esterase of the alpha-beta hydrolase superfamily
IRT44_RS17620	COG3314	Sporulation integral membrane protein YlbJ
IRT44_RS17625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IRT44_RS17630	COG0742	ribosomal rna small subunit methyltransferase
IRT44_RS17640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IRT44_RS17650	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IRT44_RS17665	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IRT44_RS17670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IRT44_RS17680	COG1793	dna ligase
IRT44_RS17700	COG0697	spore germination
IRT44_RS17705	COG1793	dna ligase
IRT44_RS17705	COG3285	dna ligase
IRT44_RS17710	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IRT44_RS17720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_RS17725	COG4569	acetaldehyde dehydrogenase (acetylating) activity
IRT44_RS17740	COG0251	oxidation-reduction process
IRT44_RS17760	COG0431	NADPH-dependent FMN reductase
IRT44_RS17765	COG2368	4-hydroxyphenylacetate
IRT44_RS17775	COG0840	transmembrane signaling receptor activity
IRT44_RS17795	COG0306	phosphate transporter
IRT44_RS17805	COG3706	GGDEF domain
IRT44_RS17810	COG2814	Major facilitator Superfamily
IRT44_RS17815	COG3424	synthase
IRT44_RS17820	COG1755	Isoprenylcysteine carboxyl methyltransferase
IRT44_RS17835	COG1846	Transcriptional regulator
IRT44_RS17840	COG0681	Belongs to the peptidase S26 family
IRT44_RS17860	COG1876	peptidase activity
IRT44_RS17865	COG0405	Gamma-glutamyltransferase
IRT44_RS17870	COG5434	Belongs to the glycosyl hydrolase 28 family
IRT44_RS17870	COG4632	Exopolysaccharide biosynthesis protein
IRT44_RS17895	COG0714	Associated with various cellular activities
IRT44_RS17920	COG0438	transferase activity, transferring glycosyl groups
IRT44_RS17925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IRT44_RS17935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_RS17955	COG3546	catalase activity
IRT44_RS17980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IRT44_RS17995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IRT44_RS18000	COG1760	l-serine dehydratase
IRT44_RS18005	COG1760	l-serine dehydratase
IRT44_RS18010	COG1307	EDD domain protein, DegV family
IRT44_RS18015	COG1461	Dihydroxyacetone kinase
IRT44_RS18020	COG1302	Protein conserved in bacteria
IRT44_RS18025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IRT44_RS18035	COG3859	Proton-coupled thiamine transporter YuaJ
IRT44_RS18040	COG1126	abc transporter atp-binding protein
IRT44_RS18045	COG0765	amino acid transport
IRT44_RS18050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IRT44_RS18055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IRT44_RS18065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IRT44_RS18075	COG0515	serine threonine protein kinase
IRT44_RS18075	COG2815	serine threonine protein kinase
IRT44_RS18080	COG0631	protein serine/threonine phosphatase activity
IRT44_RS18085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IRT44_RS18090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IRT44_RS18090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IRT44_RS18095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IRT44_RS18100	COG0242	peptide deformylase activity
IRT44_RS18105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IRT44_RS18110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IRT44_RS18115	COG1758	RNA polymerase activity
IRT44_RS18120	COG0194	GDP metabolic process
IRT44_RS18125	COG2052	Domain of unknown function (DUF370)
IRT44_RS18130	COG1561	YicC-like family, N-terminal region
IRT44_RS18160	COG1024	Enoyl-CoA hydratase
IRT44_RS18165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IRT44_RS18200	COG1547	Domain of unknown function (DUF309)
IRT44_RS18215	COG4846	Membrane protein involved in cytochrome C biogenesis
IRT44_RS18220	COG0531	amino acid
IRT44_RS18235	COG0477	Major facilitator Superfamily
IRT44_RS18240	COG1335	isochorismatase
IRT44_RS18245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IRT44_RS18250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IRT44_RS18255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IRT44_RS18260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IRT44_RS18265	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IRT44_RS18270	COG0460	homoserine dehydrogenase
IRT44_RS18285	COG0284	orotidine-5'-phosphate decarboxylase activity
IRT44_RS18290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IRT44_RS18300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IRT44_RS18305	COG0540	Belongs to the ATCase OTCase family
IRT44_RS18315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IRT44_RS18325	COG0564	pseudouridine synthase activity
IRT44_RS18330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IRT44_RS18335	COG2112	serine threonine protein kinase
IRT44_RS18340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IRT44_RS18350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IRT44_RS18370	COG3546	catalase activity
IRT44_RS18400	COG1842	Phage shock protein A
IRT44_RS18405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IRT44_RS18425	COG1316	TRANSCRIPTIONal
IRT44_RS18430	COG0492	ferredoxin-NADP+ reductase activity
IRT44_RS18435	COG0494	nUDIX hydrolase
IRT44_RS18440	COG2814	Major facilitator Superfamily
IRT44_RS18445	COG4948	Mandelate Racemase Muconate Lactonizing
IRT44_RS18450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IRT44_RS18455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IRT44_RS18460	COG3599	regulation of cell shape
IRT44_RS18465	COG2302	S4 RNA-binding domain
IRT44_RS18470	COG0762	integral membrane protein
IRT44_RS18475	COG1799	cell septum assembly
IRT44_RS18480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IRT44_RS18485	COG1496	oxidoreductase activity
IRT44_RS18490	COG1873	PFAM PRC-barrel domain
IRT44_RS18495	COG1191	sigma factor activity
IRT44_RS18500	COG1191	sigma factor activity
IRT44_RS18515	COG1120	ATPase activity
IRT44_RS18520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IRT44_RS18525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IRT44_RS18540	COG2801	Transposase and inactivated derivatives
IRT44_RS18545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IRT44_RS18550	COG0849	cell division
IRT44_RS18555	COG3856	small basic protein
IRT44_RS18570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IRT44_RS18575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IRT44_RS18580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IRT44_RS18590	COG0772	Belongs to the SEDS family
IRT44_RS18595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IRT44_RS18600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IRT44_RS18610	COG0768	penicillin binding
IRT44_RS18615	COG0768	penicillin binding
IRT44_RS18625	COG0275	rRNA processing
IRT44_RS18630	COG2001	Belongs to the MraZ family
IRT44_RS18635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IRT44_RS18640	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IRT44_RS18645	COG1396	sequence-specific DNA binding
IRT44_RS18655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IRT44_RS18660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IRT44_RS18665	COG1024	Enoyl-CoA hydratase
IRT44_RS18670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IRT44_RS18675	COG0511	ligase activity, forming carbon-carbon bonds
IRT44_RS18680	COG0439	Biotin carboxylase
IRT44_RS18685	COG0454	-acetyltransferase
IRT44_RS18695	COG1024	Enoyl-CoA hydratase
IRT44_RS18700	COG1393	Belongs to the ArsC family
IRT44_RS18725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_RS18760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IRT44_RS18770	COG0626	cystathionine gamma-synthase activity
IRT44_RS18775	COG0626	cystathionine gamma-synthase activity
IRT44_RS18805	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IRT44_RS18815	COG1217	gtp-binding protein TYPA
IRT44_RS18820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IRT44_RS18845	COG4493	Belongs to the UPF0637 family
IRT44_RS18855	COG1982	Orn Lys Arg decarboxylase major
IRT44_RS18870	COG2267	carboxylic ester hydrolase activity
IRT44_RS18900	COG1473	amidohydrolase
IRT44_RS18905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IRT44_RS18910	COG2171	N-acyltransferase activity
IRT44_RS18915	COG0716	FMN binding
IRT44_RS18925	COG2217	Heavy metal translocating P-type atpase
IRT44_RS18945	COG2226	methyltransferase
IRT44_RS18950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IRT44_RS18955	COG1136	(ABC) transporter
IRT44_RS18955	COG0577	efflux transmembrane transporter activity
IRT44_RS18960	COG1136	(ABC) transporter
IRT44_RS18960	COG0577	efflux transmembrane transporter activity
IRT44_RS18970	COG0351	phosphomethylpyrimidine kinase
IRT44_RS18975	COG2962	Rard protein
IRT44_RS19040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IRT44_RS19045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_RS19050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IRT44_RS19055	COG3718	enzyme involved in inositol metabolism
IRT44_RS19060	COG1082	Xylose isomerase domain protein TIM barrel
IRT44_RS19065	COG3962	Belongs to the TPP enzyme family
IRT44_RS19070	COG1172	Belongs to the binding-protein-dependent transport system permease family
IRT44_RS19075	COG1129	ABC transporter
IRT44_RS19085	COG0673	inositol 2-dehydrogenase activity
IRT44_RS19090	COG0673	inositol 2-dehydrogenase activity
IRT44_RS19095	COG1609	Transcriptional regulator
IRT44_RS19105	COG1695	Transcriptional regulator
IRT44_RS19135	COG1061	Type III restriction enzyme res subunit
IRT44_RS19145	COG0537	adenosine 5'-monophosphoramidase activity
IRT44_RS19160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IRT44_RS19185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IRT44_RS19205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IRT44_RS19225	COG3344	reverse transcriptase
IRT44_RS19240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IRT44_RS19255	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IRT44_RS19265	COG0613	PHP domain protein
IRT44_RS19275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IRT44_RS19280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IRT44_RS19285	COG1253	flavin adenine dinucleotide binding
IRT44_RS19335	COG1466	dna polymerase III delta subunit
IRT44_RS19340	COG1466	dna polymerase III delta subunit