locus-tag	class	description
GRQ40_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GRQ40_RS00010	COG0592	DNA-directed DNA polymerase activity
GRQ40_RS00015	COG2501	S4 domain
GRQ40_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GRQ40_RS00025	COG0187	DNA topoisomerase II activity
GRQ40_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GRQ40_RS00085	COG0517	IMP dehydrogenase activity
GRQ40_RS00085	COG0516	GMP reductase activity
GRQ40_RS00095	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GRQ40_RS00100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GRQ40_RS00105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GRQ40_RS00115	COG1428	Deoxynucleoside kinase
GRQ40_RS00120	COG1428	Deoxynucleoside kinase
GRQ40_RS00125	COG3858	chitin binding
GRQ40_RS00125	COG1388	LysM domain
GRQ40_RS00130	COG0590	tRNA wobble adenosine to inosine editing
GRQ40_RS00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GRQ40_RS00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GRQ40_RS00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GRQ40_RS00205	COG1982	Orn Lys Arg decarboxylase major
GRQ40_RS00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GRQ40_RS00215	COG0470	DNA polymerase III
GRQ40_RS00220	COG1774	PSP1 C-terminal conserved region
GRQ40_RS00225	COG4467	Involved in initiation control of chromosome replication
GRQ40_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GRQ40_RS00235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GRQ40_RS00240	COG2002	toxin-antitoxin pair type II binding
GRQ40_RS00250	COG0084	hydrolase, TatD family'
GRQ40_RS00255	COG3584	3D domain protein
GRQ40_RS00255	COG3583	domain protein
GRQ40_RS00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GRQ40_RS00275	COG4466	Protein conserved in bacteria
GRQ40_RS00285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GRQ40_RS00290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GRQ40_RS00295	COG0251	oxidation-reduction process
GRQ40_RS00300	COG2088	sporulation resulting in formation of a cellular spore
GRQ40_RS00305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GRQ40_RS00315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GRQ40_RS00320	COG0193	aminoacyl-tRNA hydrolase activity
GRQ40_RS00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GRQ40_RS00335	COG2002	toxin-antitoxin pair type II binding
GRQ40_RS00340	COG2244	polysaccharide biosynthetic process
GRQ40_RS00345	COG3956	TIGRFAM MazG family protein
GRQ40_RS00350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GRQ40_RS00370	COG1098	S1 RNA binding domain
GRQ40_RS00385	COG2208	phosphoserine phosphatase activity
GRQ40_RS00390	COG2304	oxidoreductase activity
GRQ40_RS00395	COG0515	serine threonine protein kinase
GRQ40_RS00400	COG0037	tRNA processing
GRQ40_RS00410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GRQ40_RS00415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GRQ40_RS00420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GRQ40_RS00425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GRQ40_RS00430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GRQ40_RS00435	COG0512	Glutamine amidotransferase of anthranilate synthase
GRQ40_RS00440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GRQ40_RS00445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GRQ40_RS00450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GRQ40_RS00455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GRQ40_RS00460	COG1396	sequence-specific DNA binding
GRQ40_RS00465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GRQ40_RS00555	COG3880	PFAM UvrB UvrC protein
GRQ40_RS00560	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GRQ40_RS00565	COG0542	response to heat
GRQ40_RS00570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GRQ40_RS00575	COG4956	integral membrane protein (PIN domain superfamily)
GRQ40_RS00580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GRQ40_RS00585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GRQ40_RS00590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GRQ40_RS00595	COG1045	serine acetyltransferase
GRQ40_RS00600	COG0215	cysteine-tRNA ligase activity
GRQ40_RS00610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GRQ40_RS00615	COG3688	RNA-binding protein containing a PIN domain
GRQ40_RS00625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GRQ40_RS00630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GRQ40_RS00635	COG0250	Participates in transcription elongation, termination and antitermination
GRQ40_RS00640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GRQ40_RS00645	COG0081	regulation of translation
GRQ40_RS00650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GRQ40_RS00655	COG0222	ribosome binding
GRQ40_RS00660	COG2813	Specifically methylates the guanine in position
GRQ40_RS00665	COG0085	RNA polymerase activity
GRQ40_RS00670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GRQ40_RS00675	COG1358	cellular component organization or biogenesis
GRQ40_RS00680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GRQ40_RS00685	COG0049	tRNA binding
GRQ40_RS00690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GRQ40_RS00695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GRQ40_RS00700	COG0051	transcription antitermination factor activity, RNA binding
GRQ40_RS00705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GRQ40_RS00710	COG0088	Forms part of the polypeptide exit tunnel
GRQ40_RS00715	COG0089	rRNA binding
GRQ40_RS00720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GRQ40_RS00725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GRQ40_RS00730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GRQ40_RS00735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GRQ40_RS00740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GRQ40_RS00745	COG0255	Belongs to the universal ribosomal protein uL29 family
GRQ40_RS00750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GRQ40_RS00755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GRQ40_RS00760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GRQ40_RS00765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GRQ40_RS00770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GRQ40_RS00775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GRQ40_RS00785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GRQ40_RS00790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GRQ40_RS00795	COG1841	ribosomal large subunit assembly
GRQ40_RS00800	COG0200	Binds to the 23S rRNA
GRQ40_RS00805	COG0201	protein transport
GRQ40_RS00810	COG0563	adenylate kinase activity
GRQ40_RS00815	COG0024	Methionine aminopeptidase
GRQ40_RS00820	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GRQ40_RS00825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GRQ40_RS00830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GRQ40_RS00835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GRQ40_RS00840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GRQ40_RS00845	COG0202	RNA polymerase activity
GRQ40_RS00850	COG0203	ribosomal protein L17
GRQ40_RS00855	COG1122	ATPase activity
GRQ40_RS00860	COG1122	ATPase activity
GRQ40_RS00865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GRQ40_RS00870	COG0101	tRNA pseudouridine synthase activity
GRQ40_RS00875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GRQ40_RS00880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GRQ40_RS00895	COG0463	Glycosyl transferase, family 2
GRQ40_RS00895	COG0457	Tetratricopeptide repeat
GRQ40_RS00905	COG0457	Tetratricopeptide repeat
GRQ40_RS00905	COG0463	Glycosyl transferase, family 2
GRQ40_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
GRQ40_RS00920	COG0489	protein tyrosine kinase activity
GRQ40_RS00930	COG2194	sulfuric ester hydrolase activity
GRQ40_RS00935	COG0726	polysaccharide deacetylase
GRQ40_RS01020	COG1595	DNA-templated transcription, initiation
GRQ40_RS01025	COG5662	AntiSigma factor
GRQ40_RS01030	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GRQ40_RS01035	COG4856	YbbR-like protein
GRQ40_RS01040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GRQ40_RS01045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GRQ40_RS01145	COG0582	viral genome integration into host DNA
GRQ40_RS01240	COG1131	(ABC) transporter
GRQ40_RS01255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GRQ40_RS01265	COG0456	acetyltransferase
GRQ40_RS01270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GRQ40_RS01270	COG3153	acetyltransferase
GRQ40_RS01275	COG1733	regulation of RNA biosynthetic process
GRQ40_RS01285	COG0726	polysaccharide deacetylase
GRQ40_RS01300	COG0778	Nitroreductase
GRQ40_RS01305	COG2207	Transcriptional regulator
GRQ40_RS01305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRQ40_RS01310	COG2814	Major facilitator Superfamily
GRQ40_RS01345	COG0351	phosphomethylpyrimidine kinase
GRQ40_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS01355	COG1169	isochorismate synthase
GRQ40_RS01360	COG1021	2,3-dihydroxybenzoate-AMP ligase
GRQ40_RS01365	COG1535	isochorismatase
GRQ40_RS01365	COG3433	isochorismatase activity
GRQ40_RS01370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GRQ40_RS01375	COG3251	PFAM MbtH domain protein
GRQ40_RS01385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRQ40_RS01385	COG2207	Transcriptional regulator
GRQ40_RS01390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRQ40_RS01395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS01400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS01405	COG0778	Nitroreductase
GRQ40_RS01410	COG2819	hydrolase of the alpha beta superfamily
GRQ40_RS01415	COG2819	hydrolase of the alpha beta superfamily
GRQ40_RS01420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS01425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS01430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRQ40_RS01435	COG1120	ATPase activity
GRQ40_RS01455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GRQ40_RS01460	COG1368	sulfuric ester hydrolase activity
GRQ40_RS01465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GRQ40_RS01470	COG0531	amino acid
GRQ40_RS01475	COG1971	Probably functions as a manganese efflux pump
GRQ40_RS01485	COG2318	DinB family
GRQ40_RS01490	COG3594	Acyltransferase
GRQ40_RS01505	COG1131	(ABC) transporter
GRQ40_RS01580	COG2197	response regulator
GRQ40_RS01590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GRQ40_RS01595	COG0726	polysaccharide deacetylase
GRQ40_RS01600	COG0586	Pfam SNARE associated Golgi protein
GRQ40_RS01605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GRQ40_RS01610	COG1181	Belongs to the D-alanine--D-alanine ligase family
GRQ40_RS01615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GRQ40_RS01625	COG0513	Belongs to the DEAD box helicase family
GRQ40_RS01630	COG0705	Rhomboid family
GRQ40_RS01635	COG0736	holo-[acyl-carrier-protein] synthase activity
GRQ40_RS01640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GRQ40_RS01645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GRQ40_RS01650	COG0864	Transcriptional regulator
GRQ40_RS01655	COG2337	Toxic component of a toxin-antitoxin (TA) module
GRQ40_RS01660	COG2183	response to ionizing radiation
GRQ40_RS01670	COG3091	SprT-like family
GRQ40_RS01760	COG0802	atpase or kinase
GRQ40_RS01765	COG1214	PFAM Peptidase M22, glycoprotease
GRQ40_RS01770	COG0456	acetyltransferase
GRQ40_RS01775	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GRQ40_RS01780	COG0488	(ABC) transporter
GRQ40_RS01785	COG0315	cyclic pyranopterin monophosphate synthase activity
GRQ40_RS01790	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GRQ40_RS01795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GRQ40_RS01800	COG0805	protein transport
GRQ40_RS01810	COG1266	CAAX protease self-immunity
GRQ40_RS01815	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GRQ40_RS01825	COG0714	Associated with various cellular activities
GRQ40_RS01830	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GRQ40_RS01835	COG1305	Transglutaminase-like
GRQ40_RS01840	COG0519	Catalyzes the synthesis of GMP from XMP
GRQ40_RS01840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GRQ40_RS01845	COG2252	PERMEase
GRQ40_RS01850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GRQ40_RS01875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GRQ40_RS01880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GRQ40_RS01885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GRQ40_RS01890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GRQ40_RS01895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GRQ40_RS01900	COG0047	phosphoribosylformylglycinamidine synthase activity
GRQ40_RS01905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GRQ40_RS01910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GRQ40_RS01915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GRQ40_RS01920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GRQ40_RS01925	COG0138	bifunctional purine biosynthesis protein purh
GRQ40_RS01930	COG0151	Belongs to the GarS family
GRQ40_RS01945	COG1470	cell adhesion involved in biofilm formation
GRQ40_RS01950	COG4496	protein, YerC YecD
GRQ40_RS01955	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GRQ40_RS01965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GRQ40_RS01970	COG4851	CamS sex pheromone cAM373 precursor
GRQ40_RS01975	COG1012	belongs to the aldehyde dehydrogenase family
GRQ40_RS01985	COG2197	response regulator
GRQ40_RS02010	COG1131	(ABC) transporter
GRQ40_RS02035	COG1136	(ABC) transporter
GRQ40_RS02050	COG3284	Transcriptional regulator
GRQ40_RS02055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GRQ40_RS02060	COG0022	dehydrogenase e1 component
GRQ40_RS02065	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRQ40_RS02070	COG0726	polysaccharide deacetylase
GRQ40_RS02075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GRQ40_RS02105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GRQ40_RS02110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GRQ40_RS02115	COG0154	amidase activity
GRQ40_RS02120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GRQ40_RS02125	COG1732	Glycine betaine
GRQ40_RS02130	COG1125	glycine betaine transport
GRQ40_RS02130	COG0517	IMP dehydrogenase activity
GRQ40_RS02135	COG1174	glycine betaine transport
GRQ40_RS02165	COG1518	maintenance of DNA repeat elements
GRQ40_RS02170	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GRQ40_RS02180	COG3842	ATPase activity
GRQ40_RS02185	COG1176	ABC-type spermidine putrescine transport system, permease component I
GRQ40_RS02195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GRQ40_RS02215	COG5002	protein histidine kinase activity
GRQ40_RS02225	COG1585	Membrane protein implicated in regulation of membrane protease activity
GRQ40_RS02230	COG2268	Band 7 protein
GRQ40_RS02235	COG1595	DNA-templated transcription, initiation
GRQ40_RS02255	COG1597	lipid kinase activity
GRQ40_RS02265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GRQ40_RS02295	COG1131	(ABC) transporter
GRQ40_RS02300	COG0501	Belongs to the peptidase M48B family
GRQ40_RS02310	COG1309	transcriptional regulator
GRQ40_RS02330	COG1136	(ABC) transporter
GRQ40_RS02330	COG0577	efflux transmembrane transporter activity
GRQ40_RS02360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GRQ40_RS02365	COG0833	amino acid
GRQ40_RS02370	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GRQ40_RS02375	COG2084	Dehydrogenase
GRQ40_RS02380	COG3290	protein histidine kinase activity
GRQ40_RS02380	COG0840	transmembrane signaling receptor activity
GRQ40_RS02385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GRQ40_RS02400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GRQ40_RS02405	COG2068	MobA-Related Protein
GRQ40_RS02410	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GRQ40_RS02435	COG2986	histidine ammonia-lyase
GRQ40_RS02440	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GRQ40_RS02445	COG1228	amidohydrolase
GRQ40_RS02450	COG0861	Integral membrane protein TerC family
GRQ40_RS02455	COG1556	Lactate utilization protein
GRQ40_RS02460	COG1139	Iron-sulfur cluster binding protein
GRQ40_RS02465	COG0247	lactate metabolic process
GRQ40_RS02470	COG2186	Transcriptional regulator
GRQ40_RS02475	COG1620	l-lactate permease
GRQ40_RS02480	COG0277	FAD linked oxidase domain protein
GRQ40_RS02485	COG0247	lactate metabolic process
GRQ40_RS02490	COG0791	NLP P60 protein
GRQ40_RS02490	COG1388	LysM domain
GRQ40_RS02520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GRQ40_RS02525	COG0010	Belongs to the arginase family
GRQ40_RS02530	COG1254	Belongs to the acylphosphatase family
GRQ40_RS02550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GRQ40_RS02555	COG0529	Catalyzes the synthesis of activated sulfate
GRQ40_RS02560	COG2046	Belongs to the sulfate adenylyltransferase family
GRQ40_RS02565	COG0306	phosphate transporter
GRQ40_RS02570	COG0175	sulfate reduction
GRQ40_RS02580	COG4840	Belongs to the UPF0435 family
GRQ40_RS02585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GRQ40_RS02595	COG1295	ribonuclease BN
GRQ40_RS02605	COG0477	Major facilitator Superfamily
GRQ40_RS02615	COG0387	Pfam Sodium calcium exchanger
GRQ40_RS02630	COG0535	radical SAM domain protein
GRQ40_RS02650	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GRQ40_RS02655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GRQ40_RS02670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GRQ40_RS02695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GRQ40_RS02695	COG3321	synthase
GRQ40_RS02695	COG4221	oxidoreductase activity
GRQ40_RS02695	COG0300	oxidoreductase activity
GRQ40_RS02725	COG2091	lysine biosynthetic process via aminoadipic acid
GRQ40_RS02765	COG0586	Pfam SNARE associated Golgi protein
GRQ40_RS02780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GRQ40_RS02815	COG0733	neurotransmitter:sodium symporter activity
GRQ40_RS02830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GRQ40_RS02835	COG2079	MmgE PrpD family protein
GRQ40_RS02850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GRQ40_RS02855	COG1607	acyl-coa hydrolase
GRQ40_RS02865	COG2197	response regulator
GRQ40_RS02895	COG1090	epimerase
GRQ40_RS02900	COG2137	regulation of response to DNA damage stimulus
GRQ40_RS02930	COG1988	membrane-bound metal-dependent
GRQ40_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS02960	COG3557	Belongs to the UPF0374 family
GRQ40_RS02970	COG0444	Belongs to the ABC transporter superfamily
GRQ40_RS02975	COG4608	Belongs to the ABC transporter superfamily
GRQ40_RS02980	COG0747	negative chemotaxis
GRQ40_RS03005	COG4129	membrane
GRQ40_RS03025	COG0070	glutamate synthase
GRQ40_RS03025	COG0067	glutamate synthase
GRQ40_RS03025	COG0069	glutamate synthase activity
GRQ40_RS03030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GRQ40_RS03035	COG4555	ABC transporter
GRQ40_RS03055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GRQ40_RS03060	COG0735	belongs to the Fur family
GRQ40_RS03210	COG3382	B3 4 domain protein
GRQ40_RS03215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GRQ40_RS03225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GRQ40_RS03230	COG2766	serine protein kinase
GRQ40_RS03250	COG1136	(ABC) transporter
GRQ40_RS03255	COG0577	efflux transmembrane transporter activity
GRQ40_RS03255	COG1136	(ABC) transporter
GRQ40_RS03260	COG0745	RESPONSE REGULATOR receiver
GRQ40_RS03265	COG5002	protein histidine kinase activity
GRQ40_RS03280	COG3290	protein histidine kinase activity
GRQ40_RS03285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GRQ40_RS03290	COG1301	dicarboxylic acid transport
GRQ40_RS03295	COG1741	Belongs to the pirin family
GRQ40_RS03300	COG0655	NAD(P)H dehydrogenase (quinone) activity
GRQ40_RS03305	COG0656	L-ascorbic acid biosynthetic process
GRQ40_RS03310	COG2738	Putative neutral zinc metallopeptidase
GRQ40_RS03315	COG1253	flavin adenine dinucleotide binding
GRQ40_RS03320	COG0564	pseudouridine synthase activity
GRQ40_RS03335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GRQ40_RS03350	COG0517	IMP dehydrogenase activity
GRQ40_RS03355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GRQ40_RS03360	COG4221	oxidoreductase activity
GRQ40_RS03365	COG2203	Gaf domain
GRQ40_RS03365	COG4585	Histidine kinase
GRQ40_RS03370	COG2197	response regulator
GRQ40_RS03395	COG0586	Pfam SNARE associated Golgi protein
GRQ40_RS03425	COG2719	SpoVR family
GRQ40_RS03445	COG1937	Protein conserved in bacteria
GRQ40_RS03450	COG0425	Belongs to the sulfur carrier protein TusA family
GRQ40_RS03455	COG2210	Belongs to the sulfur carrier protein TusA family
GRQ40_RS03470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GRQ40_RS03470	COG0425	Belongs to the sulfur carrier protein TusA family
GRQ40_RS03475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GRQ40_RS03475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GRQ40_RS03480	COG0730	response to heat
GRQ40_RS03485	COG0386	Belongs to the glutathione peroxidase family
GRQ40_RS03490	COG2514	catechol 2,3-dioxygenase activity
GRQ40_RS03495	COG0716	FMN binding
GRQ40_RS03505	COG0861	Integral membrane protein TerC family
GRQ40_RS03510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GRQ40_RS03515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GRQ40_RS03525	COG1966	Carbon starvation protein
GRQ40_RS03530	COG2879	small protein
GRQ40_RS03535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GRQ40_RS03540	COG0366	Alpha amylase catalytic
GRQ40_RS03545	COG2318	DinB family
GRQ40_RS03555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GRQ40_RS03565	COG1122	ATPase activity
GRQ40_RS03570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GRQ40_RS03575	COG0352	thiamine-phosphate diphosphorylase activity
GRQ40_RS03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRQ40_RS03585	COG2104	thiamine diphosphate biosynthetic process
GRQ40_RS03590	COG2022	thiamine diphosphate biosynthetic process
GRQ40_RS03595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GRQ40_RS03600	COG1253	flavin adenine dinucleotide binding
GRQ40_RS03605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRQ40_RS03610	COG0765	amino acid transport
GRQ40_RS03615	COG1126	abc transporter atp-binding protein
GRQ40_RS03630	COG3842	ATPase activity
GRQ40_RS03635	COG2508	Transcriptional regulator
GRQ40_RS03650	COG4399	Belongs to the UPF0754 family
GRQ40_RS03655	COG3679	Belongs to the UPF0342 family
GRQ40_RS03660	COG0561	phosphatase activity
GRQ40_RS03665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GRQ40_RS03675	COG4152	abc transporter atp-binding protein
GRQ40_RS03680	COG1668	transmembrane transport
GRQ40_RS03685	COG3481	metal-dependent phosphohydrolase, HD sub domain
GRQ40_RS03695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GRQ40_RS03705	COG1846	Transcriptional regulator
GRQ40_RS03725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GRQ40_RS03730	COG0537	adenosine 5'-monophosphoramidase activity
GRQ40_RS03735	COG1131	(ABC) transporter
GRQ40_RS03740	COG4473	ABC transporter
GRQ40_RS03745	COG2329	Antibiotic biosynthesis monooxygenase
GRQ40_RS03750	COG3069	C4-dicarboxylate transmembrane transporter activity
GRQ40_RS03755	COG1473	amidohydrolase
GRQ40_RS03760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GRQ40_RS03775	COG1309	transcriptional regulator
GRQ40_RS03780	COG1511	domain protein
GRQ40_RS03785	COG1609	Transcriptional regulator
GRQ40_RS03790	COG1653	transport
GRQ40_RS03810	COG1234	tRNA 3'-trailer cleavage
GRQ40_RS03815	COG0318	PFAM AMP-dependent synthetase and ligase
GRQ40_RS03820	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GRQ40_RS03840	COG0501	Belongs to the peptidase M48B family
GRQ40_RS03845	COG2224	Isocitrate lyase
GRQ40_RS03855	COG4903	ComK protein
GRQ40_RS03860	COG0398	Pfam SNARE associated Golgi protein
GRQ40_RS03870	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GRQ40_RS03875	COG1074	ATP-dependent DNA helicase activity
GRQ40_RS03880	COG0420	3'-5' exonuclease activity
GRQ40_RS03885	COG0419	ATPase involved in DNA repair
GRQ40_RS03930	COG0318	PFAM AMP-dependent synthetase and ligase
GRQ40_RS03935	COG2311	Membrane
GRQ40_RS03945	COG0179	Fumarylacetoacetate (FAA) hydrolase
GRQ40_RS03950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GRQ40_RS03965	COG0367	asparagine synthase
GRQ40_RS03970	COG0534	Mate efflux family protein
GRQ40_RS03975	COG2207	Transcriptional regulator
GRQ40_RS03975	COG1917	Cupin 2, conserved barrel domain protein
GRQ40_RS03985	COG2182	Extracellular solute-binding protein
GRQ40_RS03990	COG1175	transmembrane transport
GRQ40_RS03995	COG3833	ABC-type maltose transport systems, permease component
GRQ40_RS04000	COG0366	Alpha amylase catalytic
GRQ40_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS04025	COG0646	methionine synthase
GRQ40_RS04025	COG1410	methionine synthase
GRQ40_RS04030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GRQ40_RS04030	COG0646	methionine synthase
GRQ40_RS04040	COG2996	Protein conserved in bacteria
GRQ40_RS04050	COG0840	transmembrane signaling receptor activity
GRQ40_RS04065	COG1131	(ABC) transporter
GRQ40_RS04070	COG4585	Histidine kinase
GRQ40_RS04085	COG1307	EDD domain protein, DegV family
GRQ40_RS04090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GRQ40_RS04100	COG0561	phosphatase activity
GRQ40_RS04105	COG1073	alpha beta
GRQ40_RS04110	COG0746	molybdenum cofactor guanylyltransferase activity
GRQ40_RS04115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GRQ40_RS04120	COG0303	'Molybdopterin
GRQ40_RS04125	COG1763	Mo-molybdopterin cofactor biosynthetic process
GRQ40_RS04130	COG0314	molybdopterin synthase activity
GRQ40_RS04140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GRQ40_RS04145	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GRQ40_RS04150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GRQ40_RS04170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GRQ40_RS04190	COG2267	carboxylic ester hydrolase activity
GRQ40_RS04205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GRQ40_RS04210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GRQ40_RS04215	COG5504	Zn-dependent protease
GRQ40_RS04235	COG4166	transmembrane transport
GRQ40_RS04240	COG0601	transmembrane transport
GRQ40_RS04245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GRQ40_RS04250	COG0444	Belongs to the ABC transporter superfamily
GRQ40_RS04255	COG4608	Belongs to the ABC transporter superfamily
GRQ40_RS04265	COG1393	Belongs to the ArsC family
GRQ40_RS04270	COG0861	Integral membrane protein TerC family
GRQ40_RS04275	COG4862	establishment of competence for transformation
GRQ40_RS04280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GRQ40_RS04290	COG1164	Oligoendopeptidase f
GRQ40_RS04305	COG2346	COG2346, Truncated hemoglobins
GRQ40_RS04310	COG0741	lytic transglycosylase activity
GRQ40_RS04315	COG4116	CYTH
GRQ40_RS04325	COG2357	RelA SpoT domain protein
GRQ40_RS04330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GRQ40_RS04335	COG0564	pseudouridine synthase activity
GRQ40_RS04340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GRQ40_RS04345	COG0772	Belongs to the SEDS family
GRQ40_RS04360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GRQ40_RS04365	COG0438	transferase activity, transferring glycosyl groups
GRQ40_RS04370	COG0438	transferase activity, transferring glycosyl groups
GRQ40_RS04375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GRQ40_RS04380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GRQ40_RS04430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GRQ40_RS04445	COG2323	membrane
GRQ40_RS04450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GRQ40_RS04470	COG0210	DNA helicase
GRQ40_RS04485	COG2153	protein acetylation
GRQ40_RS04490	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GRQ40_RS04495	COG2382	esterase
GRQ40_RS04500	COG3290	protein histidine kinase activity
GRQ40_RS04500	COG3829	transcription factor binding
GRQ40_RS04505	COG2610	gluconate transmembrane transporter activity
GRQ40_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS04515	COG0626	cystathionine gamma-synthase activity
GRQ40_RS04520	COG0626	cystathionine gamma-synthase activity
GRQ40_RS04530	COG0583	DNA-binding transcription factor activity
GRQ40_RS04540	COG1418	mRNA catabolic process
GRQ40_RS04630	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GRQ40_RS04635	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GRQ40_RS04745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRQ40_RS04750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRQ40_RS04780	COG4821	SIS domain
GRQ40_RS04825	COG3730	PTS system glucitol sorbitol-specific
GRQ40_RS04830	COG3732	PTS system glucitol sorbitol-specific
GRQ40_RS04840	COG2390	Transcriptional regulator
GRQ40_RS04845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GRQ40_RS04850	COG0022	dehydrogenase e1 component
GRQ40_RS04850	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRQ40_RS04855	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRQ40_RS04860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GRQ40_RS04865	COG2390	Transcriptional regulator
GRQ40_RS04875	COG3414	Phosphotransferase system galactitol-specific IIB component
GRQ40_RS04880	COG3775	system Galactitol-specific IIC component
GRQ40_RS04900	COG0114	fumarate hydratase activity
GRQ40_RS04950	COG3655	Transcriptional regulator
GRQ40_RS04955	COG3739	integral membrane protein
GRQ40_RS04960	COG1120	ATPase activity
GRQ40_RS04965	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS04970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS04995	COG2066	Belongs to the glutaminase family
GRQ40_RS05005	COG0494	nUDIX hydrolase
GRQ40_RS05015	COG0583	DNA-binding transcription factor activity
GRQ40_RS05020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GRQ40_RS05025	COG1012	belongs to the aldehyde dehydrogenase family
GRQ40_RS05045	COG0196	riboflavin kinase activity
GRQ40_RS05055	COG3162	membrane
GRQ40_RS05060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GRQ40_RS05065	COG0179	Fumarylacetoacetate (FAA) hydrolase
GRQ40_RS05080	COG0579	oxidoreductase
GRQ40_RS05095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GRQ40_RS05100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GRQ40_RS05110	COG0346	lactoylglutathione lyase activity
GRQ40_RS05120	COG1316	TRANSCRIPTIONal
GRQ40_RS05125	COG1396	sequence-specific DNA binding
GRQ40_RS05130	COG0252	asparaginase activity
GRQ40_RS05135	COG1027	Aspartate ammonia-lyase
GRQ40_RS05145	COG1733	regulation of RNA biosynthetic process
GRQ40_RS05150	COG2814	Major facilitator Superfamily
GRQ40_RS05155	COG0656	L-ascorbic acid biosynthetic process
GRQ40_RS05165	COG2197	response regulator
GRQ40_RS05170	COG4585	Histidine kinase
GRQ40_RS05175	COG4758	membrane
GRQ40_RS05195	COG0840	transmembrane signaling receptor activity
GRQ40_RS05315	COG0277	FAD linked oxidase domain protein
GRQ40_RS05320	COG0247	lactate metabolic process
GRQ40_RS05325	COG0277	FAD linked oxidase domain protein
GRQ40_RS05330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GRQ40_RS05335	COG0179	Fumarylacetoacetate (FAA) hydrolase
GRQ40_RS05340	COG1414	Transcriptional regulator
GRQ40_RS05345	COG0475	glutathione-regulated potassium exporter activity
GRQ40_RS05350	COG0490	domain, Protein
GRQ40_RS05355	COG2966	Psort location CytoplasmicMembrane, score
GRQ40_RS05365	COG1473	amidohydrolase
GRQ40_RS05375	COG4948	Mandelate Racemase Muconate Lactonizing
GRQ40_RS05390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GRQ40_RS05395	COG3162	membrane
GRQ40_RS05400	COG0531	amino acid
GRQ40_RS05415	COG1609	Transcriptional regulator
GRQ40_RS05425	COG1653	transport
GRQ40_RS05435	COG0395	ABC-type sugar transport system, permease component
GRQ40_RS05440	COG2814	Major facilitator Superfamily
GRQ40_RS05445	COG1063	alcohol dehydrogenase
GRQ40_RS05460	COG5002	protein histidine kinase activity
GRQ40_RS05465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GRQ40_RS05475	COG4214	carbohydrate transport
GRQ40_RS05480	COG1129	ABC transporter
GRQ40_RS05485	COG1879	ABC-type sugar transport system periplasmic component
GRQ40_RS05490	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GRQ40_RS05495	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GRQ40_RS05500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GRQ40_RS05505	COG0436	Aminotransferase
GRQ40_RS05510	COG1850	ribulose-bisphosphate carboxylase activity
GRQ40_RS05515	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GRQ40_RS05520	COG0235	Class ii aldolase
GRQ40_RS05525	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GRQ40_RS05530	COG1846	Transcriptional regulator
GRQ40_RS05535	COG0531	amino acid
GRQ40_RS05545	COG1131	(ABC) transporter
GRQ40_RS05560	COG0542	response to heat
GRQ40_RS05570	COG3949	Membrane
GRQ40_RS05595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GRQ40_RS05600	COG0720	synthase
GRQ40_RS05605	COG0602	queuosine metabolic process
GRQ40_RS05620	COG0702	epimerase
GRQ40_RS05625	COG4873	Protein conserved in bacteria
GRQ40_RS05630	COG3773	Cell wall hydrolase
GRQ40_RS05655	COG4191	Histidine kinase
GRQ40_RS05660	COG0778	Nitroreductase
GRQ40_RS05680	COG5001	Diguanylate cyclase
GRQ40_RS05690	COG0475	glutathione-regulated potassium exporter activity
GRQ40_RS05695	COG2267	carboxylic ester hydrolase activity
GRQ40_RS05705	COG3711	transcriptional antiterminator
GRQ40_RS05710	COG1263	PTS System
GRQ40_RS05710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRQ40_RS05710	COG2190	(PTS) system
GRQ40_RS05725	COG0840	transmembrane signaling receptor activity
GRQ40_RS05735	COG2314	TM2 domain
GRQ40_RS05740	COG2084	Dehydrogenase
GRQ40_RS05745	COG0436	Aminotransferase
GRQ40_RS05755	COG0598	Magnesium transport protein CorA
GRQ40_RS05770	COG2205	protein histidine kinase activity
GRQ40_RS05780	COG0784	Response regulator, receiver
GRQ40_RS05780	COG0835	chemotaxis
GRQ40_RS05790	COG0248	Ppx GppA phosphatase
GRQ40_RS05795	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GRQ40_RS05800	COG1408	metallophosphoesterase
GRQ40_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS05810	COG4990	cell redox homeostasis
GRQ40_RS05815	COG2200	EAL domain
GRQ40_RS05825	COG4703	Protein of unknown function (DUF1797)
GRQ40_RS05835	COG0517	IMP dehydrogenase activity
GRQ40_RS05845	COG0583	DNA-binding transcription factor activity
GRQ40_RS05850	COG2171	N-acyltransferase activity
GRQ40_RS05855	COG1473	amidohydrolase
GRQ40_RS05865	COG0450	alkyl hydroperoxide reductase
GRQ40_RS05875	COG0569	domain protein
GRQ40_RS05885	COG0561	phosphatase activity
GRQ40_RS05940	COG1982	Orn Lys Arg decarboxylase major
GRQ40_RS05950	COG4476	Belongs to the UPF0223 family
GRQ40_RS05960	COG0483	inositol monophosphate 1-phosphatase activity
GRQ40_RS05985	COG4896	Protein conserved in bacteria
GRQ40_RS06000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GRQ40_RS06005	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GRQ40_RS06010	COG4838	Belongs to the UPF0358 family
GRQ40_RS06015	COG0772	Belongs to the SEDS family
GRQ40_RS06020	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GRQ40_RS06025	COG1612	heme a metabolic process
GRQ40_RS06030	COG0109	protoheme IX farnesyltransferase activity
GRQ40_RS06055	COG3336	cytochrome c oxidase
GRQ40_RS06075	COG2340	Cysteine-rich secretory protein family
GRQ40_RS06080	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GRQ40_RS06085	COG2340	Cysteine-rich secretory protein family
GRQ40_RS06105	COG3679	Belongs to the UPF0342 family
GRQ40_RS06110	COG4471	UPF0298 protein
GRQ40_RS06125	COG0742	ribosomal rna small subunit methyltransferase
GRQ40_RS06130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GRQ40_RS06135	COG1752	Esterase of the alpha-beta hydrolase superfamily
GRQ40_RS06140	COG3480	Lon protease (S16) C-terminal proteolytic domain
GRQ40_RS06145	COG1323	Belongs to the UPF0348 family
GRQ40_RS06150	COG1399	metal-binding, possibly nucleic acid-binding protein
GRQ40_RS06155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GRQ40_RS06160	COG1024	Enoyl-CoA hydratase
GRQ40_RS06170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GRQ40_RS06180	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GRQ40_RS06185	COG0275	rRNA processing
GRQ40_RS06190	COG4839	cell division protein FtsL
GRQ40_RS06200	COG0768	penicillin binding
GRQ40_RS06205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GRQ40_RS06215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GRQ40_RS06220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GRQ40_RS06225	COG0772	Belongs to the SEDS family
GRQ40_RS06230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GRQ40_RS06235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GRQ40_RS06240	COG3879	Bacterial protein of unknown function (DUF881)
GRQ40_RS06245	COG3879	Bacterial protein of unknown function (DUF881)
GRQ40_RS06250	COG3856	small basic protein
GRQ40_RS06255	COG0849	cell division
GRQ40_RS06260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GRQ40_RS06270	COG1191	sigma factor activity
GRQ40_RS06275	COG1191	sigma factor activity
GRQ40_RS06280	COG1873	PFAM PRC-barrel domain
GRQ40_RS06290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GRQ40_RS06295	COG1799	cell septum assembly
GRQ40_RS06300	COG0762	integral membrane protein
GRQ40_RS06305	COG2302	S4 RNA-binding domain
GRQ40_RS06310	COG3599	regulation of cell shape
GRQ40_RS06315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GRQ40_RS06320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GRQ40_RS06325	COG0564	pseudouridine synthase activity
GRQ40_RS06330	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GRQ40_RS06340	COG0540	Belongs to the ATCase OTCase family
GRQ40_RS06345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GRQ40_RS06360	COG0543	2 iron, 2 sulfur cluster binding
GRQ40_RS06365	COG0167	dihydroorotate dehydrogenase activity
GRQ40_RS06370	COG0284	orotidine-5'-phosphate decarboxylase activity
GRQ40_RS06390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GRQ40_RS06395	COG1561	YicC-like family, N-terminal region
GRQ40_RS06400	COG2052	Domain of unknown function (DUF370)
GRQ40_RS06405	COG0194	GDP metabolic process
GRQ40_RS06410	COG1758	RNA polymerase activity
GRQ40_RS06415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GRQ40_RS06420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GRQ40_RS06425	COG0242	peptide deformylase activity
GRQ40_RS06430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GRQ40_RS06435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GRQ40_RS06435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GRQ40_RS06440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GRQ40_RS06445	COG0631	protein serine/threonine phosphatase activity
GRQ40_RS06450	COG2815	serine threonine protein kinase
GRQ40_RS06450	COG0515	serine threonine protein kinase
GRQ40_RS06455	COG1162	GTPase activity
GRQ40_RS06460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GRQ40_RS06465	COG1564	THIamine pyrophosphokinase
GRQ40_RS06475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GRQ40_RS06480	COG1302	Protein conserved in bacteria
GRQ40_RS06485	COG1461	Dihydroxyacetone kinase
GRQ40_RS06490	COG1760	l-serine dehydratase
GRQ40_RS06495	COG1760	l-serine dehydratase
GRQ40_RS06500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GRQ40_RS06505	COG1349	DNA-binding transcription factor activity
GRQ40_RS06510	COG0416	fatty acid biosynthetic process
GRQ40_RS06515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GRQ40_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS06525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GRQ40_RS06530	COG0571	ribonuclease III activity
GRQ40_RS06535	COG1196	nuclear chromosome segregation
GRQ40_RS06540	COG0552	protein localization to endoplasmic reticulum
GRQ40_RS06545	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GRQ40_RS06550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GRQ40_RS06555	COG0228	four-way junction DNA binding
GRQ40_RS06560	COG1837	Belongs to the UPF0109 family
GRQ40_RS06570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GRQ40_RS06575	COG0336	Belongs to the RNA methyltransferase TrmD family
GRQ40_RS06580	COG0335	large ribosomal subunit rRNA binding
GRQ40_RS06590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GRQ40_RS06595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GRQ40_RS06605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GRQ40_RS06610	COG0045	succinate-CoA ligase (ADP-forming) activity
GRQ40_RS06615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GRQ40_RS06620	COG0758	DNA mediated transformation
GRQ40_RS06625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GRQ40_RS06630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GRQ40_RS06635	COG4974	Belongs to the 'phage' integrase family
GRQ40_RS06640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GRQ40_RS06645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GRQ40_RS06650	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GRQ40_RS06655	COG1815	bacterial-type flagellum-dependent cell motility
GRQ40_RS06660	COG1558	bacterial-type flagellum-dependent cell motility
GRQ40_RS06665	COG1677	Flagellar hook-basal body complex protein FliE
GRQ40_RS06670	COG1766	The M ring may be actively involved in energy transduction
GRQ40_RS06675	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GRQ40_RS06680	COG1317	bacterial-type flagellum organization
GRQ40_RS06685	COG1157	protein secretion by the type III secretion system
GRQ40_RS06690	COG2882	bacterial-type flagellum organization
GRQ40_RS06700	COG3144	bacterial-type flagellum assembly
GRQ40_RS06705	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GRQ40_RS06710	COG4786	Flagellar basal body rod
GRQ40_RS06715	COG1582	Flagellar protein (FlbD)
GRQ40_RS06720	COG1580	Controls the rotational direction of flagella during chemotaxis
GRQ40_RS06725	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GRQ40_RS06730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GRQ40_RS06730	COG1776	CheC inhibitor of MCP methylation
GRQ40_RS06735	COG2201	protein-glutamate methylesterase activity
GRQ40_RS06740	COG3190	flagellar
GRQ40_RS06745	COG1338	Plays a role in the flagellum-specific transport system
GRQ40_RS06750	COG1987	bacterial-type flagellum assembly
GRQ40_RS06755	COG1684	flagellar biosynthetic protein fliR
GRQ40_RS06760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GRQ40_RS06765	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GRQ40_RS06770	COG1419	protein localization to endoplasmic reticulum
GRQ40_RS06775	COG0455	bacterial-type flagellum organization
GRQ40_RS06780	COG2201	protein-glutamate methylesterase activity
GRQ40_RS06785	COG0643	Histidine kinase
GRQ40_RS06785	COG2198	Histidine kinase
GRQ40_RS06790	COG0835	chemotaxis
GRQ40_RS06795	COG1776	CheC inhibitor of MCP methylation
GRQ40_RS06800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GRQ40_RS06810	COG1191	sigma factor activity
GRQ40_RS06825	COG0052	Belongs to the universal ribosomal protein uS2 family
GRQ40_RS06830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GRQ40_RS06835	COG0528	UMP kinase activity
GRQ40_RS06840	COG0233	cytoplasmic translational termination
GRQ40_RS06845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GRQ40_RS06850	COG4589	Belongs to the CDS family
GRQ40_RS06855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GRQ40_RS06860	COG0750	zinc metalloprotease
GRQ40_RS06865	COG0442	prolyl-tRNA aminoacylation
GRQ40_RS06870	COG2176	DNA-directed DNA polymerase activity
GRQ40_RS06875	COG0779	Required for maturation of 30S ribosomal subunits
GRQ40_RS06880	COG0195	Participates in both transcription termination and antitermination
GRQ40_RS06885	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GRQ40_RS06890	COG1358	cellular component organization or biogenesis
GRQ40_RS06895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GRQ40_RS06900	COG1550	Protein conserved in bacteria
GRQ40_RS06905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GRQ40_RS06910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GRQ40_RS06915	COG0196	riboflavin kinase activity
GRQ40_RS06920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GRQ40_RS06925	COG1185	polyribonucleotide nucleotidyltransferase activity
GRQ40_RS06930	COG0726	polysaccharide deacetylase
GRQ40_RS06935	COG0612	Peptidase, M16
GRQ40_RS06940	COG1873	PFAM PRC-barrel domain
GRQ40_RS06945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GRQ40_RS06950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GRQ40_RS06955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GRQ40_RS06960	COG0527	aspartate kinase activity
GRQ40_RS06970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GRQ40_RS06975	COG0740	serine-type endopeptidase activity
GRQ40_RS06985	COG4980	gas vesicle protein
GRQ40_RS06985	COG1674	ftsk spoiiie
GRQ40_RS06990	COG2188	Transcriptional regulator
GRQ40_RS07015	COG0612	Peptidase, M16
GRQ40_RS07020	COG0612	Peptidase, M16
GRQ40_RS07025	COG0300	oxidoreductase activity
GRQ40_RS07040	COG1426	Protein conserved in bacteria
GRQ40_RS07045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GRQ40_RS07050	COG1058	Belongs to the CinA family
GRQ40_RS07050	COG1546	Belongs to the CinA family
GRQ40_RS07065	COG1418	mRNA catabolic process
GRQ40_RS07070	COG1692	metallophosphoesterase
GRQ40_RS07075	COG2359	stage V sporulation protein S
GRQ40_RS07085	COG0674	pyruvate-flavodoxin oxidoreductase activity
GRQ40_RS07085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GRQ40_RS07090	COG1013	pyruvate-flavodoxin oxidoreductase activity
GRQ40_RS07095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GRQ40_RS07100	COG4550	Control of competence regulator ComK, YlbF/YmcA
GRQ40_RS07110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GRQ40_RS07115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GRQ40_RS07120	COG1737	Transcriptional regulator
GRQ40_RS07125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRQ40_RS07125	COG1263	PTS System
GRQ40_RS07135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GRQ40_RS07150	COG2340	Cysteine-rich secretory protein family
GRQ40_RS07155	COG1131	(ABC) transporter
GRQ40_RS07175	COG1376	ErfK ybiS ycfS ynhG family protein
GRQ40_RS07185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GRQ40_RS07190	COG2372	response to copper ion
GRQ40_RS07190	COG1276	copper resistance
GRQ40_RS07195	COG4549	nuclear export factor GLE1
GRQ40_RS07200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GRQ40_RS07210	COG0789	Transcriptional regulator
GRQ40_RS07215	COG1664	Polymer-forming cytoskeletal
GRQ40_RS07220	COG1664	Polymer-forming cytoskeletal
GRQ40_RS07225	COG2814	Major facilitator Superfamily
GRQ40_RS07230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GRQ40_RS07235	COG0477	Major facilitator Superfamily
GRQ40_RS07240	COG0840	transmembrane signaling receptor activity
GRQ40_RS07245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GRQ40_RS07250	COG1923	regulation of RNA biosynthetic process
GRQ40_RS07255	COG0464	growth
GRQ40_RS07275	COG0318	PFAM AMP-dependent synthetase and ligase
GRQ40_RS07280	COG1250	3-hydroxyacyl-CoA dehydrogenase
GRQ40_RS07285	COG0183	Belongs to the thiolase family
GRQ40_RS07290	COG2860	membrane
GRQ40_RS07295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GRQ40_RS07300	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GRQ40_RS07305	COG0789	Transcriptional regulator
GRQ40_RS07310	COG0174	glutamine synthetase
GRQ40_RS07355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GRQ40_RS07360	COG1388	LysM domain
GRQ40_RS07365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GRQ40_RS07370	COG4224	UPF0291 protein
GRQ40_RS07385	COG3763	UPF0154 protein
GRQ40_RS07395	COG0785	Cytochrome C biogenesis protein
GRQ40_RS07400	COG2201	protein-glutamate methylesterase activity
GRQ40_RS07405	COG4846	Membrane protein involved in cytochrome C biogenesis
GRQ40_RS07415	COG3773	Cell wall hydrolase
GRQ40_RS07435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GRQ40_RS07445	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GRQ40_RS07460	COG0328	RNA-DNA hybrid ribonuclease activity
GRQ40_RS07465	COG0328	RNA-DNA hybrid ribonuclease activity
GRQ40_RS07490	COG5001	Diguanylate cyclase
GRQ40_RS07490	COG3300	MHYT domain
GRQ40_RS07500	COG2972	Histidine kinase
GRQ40_RS07505	COG3279	Response regulator of the LytR AlgR family
GRQ40_RS07510	COG4213	ABC transporter substrate-binding protein
GRQ40_RS07515	COG1129	ABC transporter
GRQ40_RS07520	COG4214	carbohydrate transport
GRQ40_RS07530	COG0840	transmembrane signaling receptor activity
GRQ40_RS07560	COG4608	Belongs to the ABC transporter superfamily
GRQ40_RS07565	COG0601	transmembrane transport
GRQ40_RS07575	COG0747	negative chemotaxis
GRQ40_RS07585	COG3037	sugar-specific permease SgaT UlaA
GRQ40_RS07595	COG2508	Transcriptional regulator
GRQ40_RS07600	COG1012	belongs to the aldehyde dehydrogenase family
GRQ40_RS07605	COG0506	proline dehydrogenase activity
GRQ40_RS07610	COG2223	nitrite transmembrane transporter activity
GRQ40_RS07630	COG1742	UPF0060 membrane protein
GRQ40_RS07635	COG1619	proteins homologs of microcin C7 resistance protein MccF
GRQ40_RS07650	COG1082	Xylose isomerase domain protein TIM barrel
GRQ40_RS07655	COG0800	Aldolase
GRQ40_RS07670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRQ40_RS07685	COG2208	phosphoserine phosphatase activity
GRQ40_RS07705	COG0840	transmembrane signaling receptor activity
GRQ40_RS07710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GRQ40_RS07715	COG5577	PFAM Coat F domain
GRQ40_RS07750	COG4282	regulation of fungal-type cell wall biogenesis
GRQ40_RS07755	COG1609	Transcriptional regulator
GRQ40_RS07760	COG1609	Transcriptional regulator
GRQ40_RS07765	COG1070	Carbohydrate kinase
GRQ40_RS07775	COG1113	amino acid transport
GRQ40_RS07785	COG0583	DNA-binding transcription factor activity
GRQ40_RS07790	COG0069	glutamate synthase activity
GRQ40_RS07790	COG0067	glutamate synthase
GRQ40_RS07790	COG0070	glutamate synthase
GRQ40_RS07795	COG0493	'glutamate synthase
GRQ40_RS07820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GRQ40_RS07820	COG0167	dihydroorotate dehydrogenase activity
GRQ40_RS07840	COG2508	Transcriptional regulator
GRQ40_RS07845	COG1012	belongs to the aldehyde dehydrogenase family
GRQ40_RS07850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GRQ40_RS07855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GRQ40_RS07860	COG1309	transcriptional regulator
GRQ40_RS07880	COG1280	lysine exporter protein (LysE YggA)
GRQ40_RS07885	COG0784	Response regulator, receiver
GRQ40_RS07890	COG4191	Histidine kinase
GRQ40_RS07895	COG0765	amino acid transport
GRQ40_RS07900	COG0765	amino acid transport
GRQ40_RS07925	COG0840	transmembrane signaling receptor activity
GRQ40_RS07930	COG0840	transmembrane signaling receptor activity
GRQ40_RS07935	COG1012	belongs to the aldehyde dehydrogenase family
GRQ40_RS07940	COG3708	Transcriptional regulator
GRQ40_RS07940	COG2207	Transcriptional regulator
GRQ40_RS07950	COG2972	Histidine kinase
GRQ40_RS07955	COG4753	response regulator
GRQ40_RS07955	COG2207	Transcriptional regulator
GRQ40_RS07960	COG4213	ABC transporter substrate-binding protein
GRQ40_RS07970	COG4214	carbohydrate transport
GRQ40_RS07985	COG1069	ribulokinase activity
GRQ40_RS08005	COG0667	Aldo Keto reductase
GRQ40_RS08015	COG2972	Histidine kinase
GRQ40_RS08020	COG4753	response regulator
GRQ40_RS08020	COG2207	Transcriptional regulator
GRQ40_RS08025	COG1653	transport
GRQ40_RS08030	COG1175	transmembrane transport
GRQ40_RS08045	COG5578	integral membrane protein
GRQ40_RS08050	COG2115	Belongs to the xylose isomerase family
GRQ40_RS08055	COG1070	Carbohydrate kinase
GRQ40_RS08065	COG1846	Transcriptional regulator
GRQ40_RS08070	COG1024	Enoyl-CoA hydratase
GRQ40_RS08080	COG3275	phosphorelay sensor kinase activity
GRQ40_RS08085	COG3279	Response regulator of the LytR AlgR family
GRQ40_RS08095	COG0789	Transcriptional regulator
GRQ40_RS08100	COG1757	Na H antiporter
GRQ40_RS08105	COG2356	endonuclease I
GRQ40_RS08115	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GRQ40_RS08115	COG2199	diguanylate cyclase activity
GRQ40_RS08120	COG1349	DNA-binding transcription factor activity
GRQ40_RS08125	COG1105	Belongs to the carbohydrate kinase PfkB family
GRQ40_RS08130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRQ40_RS08130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRQ40_RS08130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRQ40_RS08135	COG0701	Predicted permease
GRQ40_RS08140	COG3689	TIGRFAM TIGR03943 family protein
GRQ40_RS08145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GRQ40_RS08150	COG0024	Methionine aminopeptidase
GRQ40_RS08155	COG4191	Histidine kinase
GRQ40_RS08165	COG1587	Uroporphyrinogen-III synthase
GRQ40_RS08185	COG0706	membrane insertase activity
GRQ40_RS08225	COG0310	cobalt ion transport
GRQ40_RS08230	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
GRQ40_RS08240	COG1122	ATPase activity
GRQ40_RS08265	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GRQ40_RS08295	COG1492	cobalamin metabolic process
GRQ40_RS08300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GRQ40_RS08310	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GRQ40_RS08315	COG2226	methyltransferase
GRQ40_RS08330	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GRQ40_RS08345	COG0386	Belongs to the glutathione peroxidase family
GRQ40_RS08350	COG1418	mRNA catabolic process
GRQ40_RS08355	COG1413	lyase activity
GRQ40_RS08375	COG2521	methyltransferase
GRQ40_RS08375	COG2136	Putative SAM-dependent methyltransferase
GRQ40_RS08385	COG0436	Aminotransferase
GRQ40_RS08395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GRQ40_RS08400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GRQ40_RS08410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GRQ40_RS08420	COG1307	EDD domain protein, DegV family
GRQ40_RS08425	COG1999	signal sequence binding
GRQ40_RS08430	COG2755	lipolytic protein G-D-S-L family
GRQ40_RS08440	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GRQ40_RS08440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GRQ40_RS08445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GRQ40_RS08450	COG3647	Membrane
GRQ40_RS08460	COG2195	Cleaves the N-terminal amino acid of tripeptides
GRQ40_RS08465	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GRQ40_RS08545	COG3314	Sporulation integral membrane protein YlbJ
GRQ40_RS08550	COG0523	cobalamin synthesis protein
GRQ40_RS08555	COG0701	Predicted permease
GRQ40_RS08560	COG3689	TIGRFAM TIGR03943 family protein
GRQ40_RS08575	COG1832	CoA-binding protein
GRQ40_RS08580	COG0187	DNA topoisomerase II activity
GRQ40_RS08585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GRQ40_RS08595	COG2190	(PTS) system
GRQ40_RS08600	COG2190	(PTS) system
GRQ40_RS08640	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GRQ40_RS08650	COG1959	2 iron, 2 sulfur cluster binding
GRQ40_RS08655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GRQ40_RS08655	COG1017	nitric oxide dioxygenase activity
GRQ40_RS08660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GRQ40_RS08660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GRQ40_RS08665	COG0788	formyltetrahydrofolate deformylase activity
GRQ40_RS08675	COG0714	Associated with various cellular activities
GRQ40_RS08680	COG4548	von Willebrand factor, type A
GRQ40_RS08685	COG2404	hydrolase activity, acting on ester bonds
GRQ40_RS08700	COG4974	Belongs to the 'phage' integrase family
GRQ40_RS08720	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GRQ40_RS08725	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GRQ40_RS08775	COG1074	ATP-dependent DNA helicase activity
GRQ40_RS08780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GRQ40_RS08785	COG0583	DNA-binding transcription factor activity
GRQ40_RS08790	COG2814	Major facilitator Superfamily
GRQ40_RS08865	COG1595	DNA-templated transcription, initiation
GRQ40_RS08905	COG1280	lysine exporter protein (LysE YggA)
GRQ40_RS08910	COG0456	acetyltransferase
GRQ40_RS09010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GRQ40_RS09015	COG0798	PFAM Bile acid sodium symporter
GRQ40_RS09020	COG0640	Transcriptional regulator
GRQ40_RS09035	COG1595	DNA-templated transcription, initiation
GRQ40_RS09045	COG1309	transcriptional regulator
GRQ40_RS09060	COG2814	Major facilitator Superfamily
GRQ40_RS09090	COG1819	glycosyl
GRQ40_RS09095	COG0243	molybdopterin cofactor binding
GRQ40_RS09100	COG0725	ABC transporter, periplasmic molybdate-binding protein
GRQ40_RS09105	COG1910	domain protein
GRQ40_RS09110	COG4149	molybdate abc transporter
GRQ40_RS09115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GRQ40_RS09120	COG1522	sequence-specific DNA binding
GRQ40_RS09160	COG1279	arginine transmembrane transporter activity
GRQ40_RS09165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GRQ40_RS09170	COG2031	fatty acid transporter
GRQ40_RS09180	COG3958	Transketolase
GRQ40_RS09185	COG3959	Transketolase, thiamine diphosphate binding domain
GRQ40_RS09200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRQ40_RS09205	COG1388	LysM domain
GRQ40_RS09270	COG2259	Doxx family
GRQ40_RS09275	COG0778	Nitroreductase
GRQ40_RS09285	COG0551	DNA topoisomerase type I activity
GRQ40_RS09285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GRQ40_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS09300	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GRQ40_RS09305	COG1119	ATPase activity
GRQ40_RS09325	COG0840	transmembrane signaling receptor activity
GRQ40_RS09330	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GRQ40_RS09345	COG4821	SIS domain
GRQ40_RS09350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRQ40_RS09350	COG1263	PTS System
GRQ40_RS09360	COG0363	glucosamine-6-phosphate deaminase activity
GRQ40_RS09365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GRQ40_RS09370	COG1132	(ABC) transporter
GRQ40_RS09375	COG1132	(ABC) transporter
GRQ40_RS09400	COG0583	DNA-binding transcription factor activity
GRQ40_RS09405	COG0860	N-Acetylmuramoyl-L-alanine amidase
GRQ40_RS09410	COG0110	maltose O-acetyltransferase activity
GRQ40_RS09415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GRQ40_RS09425	COG0531	amino acid
GRQ40_RS09430	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRQ40_RS09435	COG0567	Dehydrogenase, E1 component
GRQ40_RS09445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GRQ40_RS09450	COG0789	Transcriptional regulator
GRQ40_RS09455	COG2814	Major facilitator Superfamily
GRQ40_RS09465	COG0697	spore germination
GRQ40_RS09470	COG0693	protein deglycase activity
GRQ40_RS09475	COG2217	Heavy metal translocating P-type atpase
GRQ40_RS09480	COG2217	Heavy metal translocating P-type atpase
GRQ40_RS09485	COG1937	Protein conserved in bacteria
GRQ40_RS09495	COG0640	Transcriptional regulator
GRQ40_RS09500	COG3832	glyoxalase III activity
GRQ40_RS09510	COG0697	spore germination
GRQ40_RS09515	COG0494	nUDIX hydrolase
GRQ40_RS09520	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GRQ40_RS09525	COG1131	(ABC) transporter
GRQ40_RS09530	COG2755	lipolytic protein G-D-S-L family
GRQ40_RS09540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GRQ40_RS09545	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GRQ40_RS09550	COG1609	Transcriptional regulator
GRQ40_RS09560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRQ40_RS09570	COG0730	response to heat
GRQ40_RS09590	COG2258	MOSC domain
GRQ40_RS09595	COG1132	(ABC) transporter
GRQ40_RS09600	COG1132	(ABC) transporter
GRQ40_RS09615	COG2318	DinB family
GRQ40_RS09630	COG1131	(ABC) transporter
GRQ40_RS09635	COG1725	Transcriptional regulator
GRQ40_RS09640	COG2205	protein histidine kinase activity
GRQ40_RS09645	COG0697	spore germination
GRQ40_RS09650	COG0697	spore germination
GRQ40_RS09680	COG2814	Major facilitator Superfamily
GRQ40_RS09685	COG1566	PFAM secretion protein HlyD family protein
GRQ40_RS09700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GRQ40_RS09705	COG1024	Enoyl-CoA hydratase
GRQ40_RS09710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GRQ40_RS09715	COG0511	ligase activity, forming carbon-carbon bonds
GRQ40_RS09720	COG0439	Biotin carboxylase
GRQ40_RS09725	COG0318	PFAM AMP-dependent synthetase and ligase
GRQ40_RS09730	COG1960	acyl-CoA dehydrogenase activity
GRQ40_RS09735	COG1309	transcriptional regulator
GRQ40_RS09740	COG0655	NAD(P)H dehydrogenase (quinone) activity
GRQ40_RS09760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GRQ40_RS09775	COG2814	Major facilitator Superfamily
GRQ40_RS09785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GRQ40_RS09790	COG3852	Histidine kinase
GRQ40_RS09795	COG0534	Mate efflux family protein
GRQ40_RS09810	COG2962	Rard protein
GRQ40_RS09815	COG0598	Magnesium transport protein CorA
GRQ40_RS09820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GRQ40_RS09825	COG2226	methyltransferase
GRQ40_RS09835	COG1876	peptidase activity
GRQ40_RS09860	COG4326	sporulation control protein
GRQ40_RS09865	COG0515	serine threonine protein kinase
GRQ40_RS09890	COG4479	Belongs to the UPF0346 family
GRQ40_RS09900	COG1509	lysine 2,3-aminomutase activity
GRQ40_RS09905	COG0456	acetyltransferase
GRQ40_RS09910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GRQ40_RS09915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GRQ40_RS09920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GRQ40_RS09925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GRQ40_RS09930	COG0492	ferredoxin-NADP+ reductase activity
GRQ40_RS09935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GRQ40_RS09955	COG4841	protein insertion into membrane
GRQ40_RS09960	COG2050	protein possibly involved in aromatic compounds catabolism
GRQ40_RS09970	COG0824	Thioesterase
GRQ40_RS09990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GRQ40_RS10010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GRQ40_RS10015	COG1755	Isoprenylcysteine carboxyl methyltransferase
GRQ40_RS10020	COG3424	synthase
GRQ40_RS10025	COG0217	transcriptional regulatory protein
GRQ40_RS10030	COG2233	PERMEase
GRQ40_RS10035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GRQ40_RS10045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GRQ40_RS10050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GRQ40_RS10055	COG1231	oxidoreductase activity
GRQ40_RS10095	COG3209	COG3209 Rhs family protein
GRQ40_RS10180	COG3209	COG3209 Rhs family protein
GRQ40_RS10205	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GRQ40_RS10210	COG1199	ATP-dependent helicase activity
GRQ40_RS10215	COG0116	Belongs to the methyltransferase superfamily
GRQ40_RS10230	COG3599	regulation of cell shape
GRQ40_RS10235	COG4474	Belongs to the UPF0398 family
GRQ40_RS10245	COG3359	exonuclease
GRQ40_RS10250	COG1111	helicase
GRQ40_RS10250	COG1205	dead DEAH box helicase
GRQ40_RS10255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GRQ40_RS10260	COG5002	protein histidine kinase activity
GRQ40_RS10265	COG0745	RESPONSE REGULATOR receiver
GRQ40_RS10275	COG3852	Histidine kinase
GRQ40_RS10280	COG1525	nuclease
GRQ40_RS10285	COG3104	oligopeptide transport
GRQ40_RS10290	COG0833	amino acid
GRQ40_RS10295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GRQ40_RS10300	COG0352	thiamine-phosphate diphosphorylase activity
GRQ40_RS10305	COG0351	phosphomethylpyrimidine kinase
GRQ40_RS10310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GRQ40_RS10315	COG0463	Glycosyl transferase, family 2
GRQ40_RS10325	COG3383	formate dehydrogenase (NAD+) activity
GRQ40_RS10330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GRQ40_RS10335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GRQ40_RS10340	COG1984	allophanate hydrolase subunit 2
GRQ40_RS10345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GRQ40_RS10350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GRQ40_RS10350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GRQ40_RS10355	COG0791	NLP P60 protein
GRQ40_RS10355	COG1388	LysM domain
GRQ40_RS10370	COG3011	Protein conserved in bacteria
GRQ40_RS10385	COG0456	acetyltransferase
GRQ40_RS10385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GRQ40_RS10410	COG1960	acyl-CoA dehydrogenase activity
GRQ40_RS10415	COG0318	PFAM AMP-dependent synthetase and ligase
GRQ40_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS10440	COG0412	Dienelactone hydrolase
GRQ40_RS10445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GRQ40_RS10450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GRQ40_RS10455	COG1918	ferrous iron import across plasma membrane
GRQ40_RS10455	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GRQ40_RS10460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GRQ40_RS10465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GRQ40_RS10485	COG1120	ATPase activity
GRQ40_RS10490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS10495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS10500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRQ40_RS10520	COG0004	ammonium transporteR
GRQ40_RS10535	COG3853	Toxic anion resistance protein (TelA)
GRQ40_RS10575	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRQ40_RS10580	COG0022	dehydrogenase e1 component
GRQ40_RS10610	COG3327	negative regulation of DNA-templated transcription, initiation
GRQ40_RS10620	COG1024	Enoyl-CoA hydratase
GRQ40_RS10625	COG0183	Belongs to the thiolase family
GRQ40_RS10630	COG1250	3-hydroxyacyl-CoA dehydrogenase
GRQ40_RS10640	COG1024	Enoyl-CoA hydratase
GRQ40_RS10645	COG1024	Enoyl-CoA hydratase
GRQ40_RS10655	COG2151	metal-sulfur cluster biosynthetic enzyme
GRQ40_RS10670	COG3396	Phenylacetate-CoA oxygenase
GRQ40_RS10675	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GRQ40_RS10680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GRQ40_RS10695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GRQ40_RS10700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GRQ40_RS10710	COG0840	transmembrane signaling receptor activity
GRQ40_RS10720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GRQ40_RS10725	COG0561	phosphatase activity
GRQ40_RS10735	COG0129	dihydroxy-acid dehydratase activity
GRQ40_RS10740	COG2323	membrane
GRQ40_RS10760	COG3711	transcriptional antiterminator
GRQ40_RS10775	COG4989	oxidoreductase activity
GRQ40_RS10780	COG1657	PFAM Prenyltransferase squalene oxidase
GRQ40_RS10805	COG2313	pseudouridylate synthase activity
GRQ40_RS10810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRQ40_RS10810	COG1522	sequence-specific DNA binding
GRQ40_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS10835	COG0626	cystathionine gamma-synthase activity
GRQ40_RS10850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GRQ40_RS10855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GRQ40_RS10860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GRQ40_RS10865	COG1802	Transcriptional regulator
GRQ40_RS10875	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS10885	COG1970	mechanosensitive ion channel activity
GRQ40_RS10895	COG0010	Belongs to the arginase family
GRQ40_RS10900	COG1272	protein, Hemolysin III
GRQ40_RS10905	COG0656	L-ascorbic acid biosynthetic process
GRQ40_RS10910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GRQ40_RS10925	COG1024	Enoyl-CoA hydratase
GRQ40_RS10940	COG2151	metal-sulfur cluster biosynthetic enzyme
GRQ40_RS10960	COG1024	Enoyl-CoA hydratase
GRQ40_RS10965	COG0254	rRNA binding
GRQ40_RS10970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GRQ40_RS10975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GRQ40_RS10980	COG2011	ABC-type metal ion transport system permease component
GRQ40_RS10995	COG2135	peptidase activity
GRQ40_RS11010	COG4555	ABC transporter
GRQ40_RS11020	COG0438	transferase activity, transferring glycosyl groups
GRQ40_RS11025	COG0671	phosphoesterase, PA-phosphatase related
GRQ40_RS11045	COG2801	Transposase and inactivated derivatives
GRQ40_RS11085	COG3718	enzyme involved in inositol metabolism
GRQ40_RS11090	COG0191	fructose-bisphosphate aldolase activity
GRQ40_RS11095	COG1082	Xylose isomerase domain protein TIM barrel
GRQ40_RS11100	COG3962	Belongs to the TPP enzyme family
GRQ40_RS11115	COG0673	inositol 2-dehydrogenase activity
GRQ40_RS11120	COG1609	Transcriptional regulator
GRQ40_RS11125	COG1879	ABC-type sugar transport system periplasmic component
GRQ40_RS11130	COG1172	Belongs to the binding-protein-dependent transport system permease family
GRQ40_RS11135	COG1129	ABC transporter
GRQ40_RS11140	COG0673	inositol 2-dehydrogenase activity
GRQ40_RS11150	COG0531	amino acid
GRQ40_RS11180	COG1454	alcohol dehydrogenase
GRQ40_RS11190	COG3829	transcription factor binding
GRQ40_RS11190	COG3290	protein histidine kinase activity
GRQ40_RS11280	COG3654	unkown
GRQ40_RS11320	COG1181	Belongs to the D-alanine--D-alanine ligase family
GRQ40_RS11355	COG0583	DNA-binding transcription factor activity
GRQ40_RS11360	COG2814	Major facilitator Superfamily
GRQ40_RS11365	COG2246	polysaccharide biosynthetic process
GRQ40_RS11370	COG0463	Glycosyl transferase, family 2
GRQ40_RS11375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GRQ40_RS11390	COG0569	domain protein
GRQ40_RS11390	COG0475	glutathione-regulated potassium exporter activity
GRQ40_RS11405	COG4377	Putative membrane peptidase family (DUF2324)
GRQ40_RS11410	COG5658	integral membrane protein
GRQ40_RS11415	COG0640	Transcriptional regulator
GRQ40_RS11420	COG1733	regulation of RNA biosynthetic process
GRQ40_RS11440	COG1231	oxidoreductase activity
GRQ40_RS11530	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GRQ40_RS11535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GRQ40_RS11540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GRQ40_RS11545	COG2217	Heavy metal translocating P-type atpase
GRQ40_RS11555	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GRQ40_RS11560	COG5002	protein histidine kinase activity
GRQ40_RS11565	COG0745	RESPONSE REGULATOR receiver
GRQ40_RS11600	COG3331	DNA recombination
GRQ40_RS11605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GRQ40_RS11605	COG4499	WXG100 protein secretion system (Wss), protein YukC
GRQ40_RS11615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GRQ40_RS11620	COG3935	DnaD domain protein
GRQ40_RS11625	COG0017	Asparaginyl-tRNA synthetase
GRQ40_RS11635	COG5353	protein conserved in bacteria
GRQ40_RS11645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GRQ40_RS11645	COG1199	ATP-dependent helicase activity
GRQ40_RS11650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GRQ40_RS11655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GRQ40_RS11660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GRQ40_RS11670	COG0617	tRNA 3'-terminal CCA addition
GRQ40_RS11675	COG0438	transferase activity, transferring glycosyl groups
GRQ40_RS11680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GRQ40_RS11685	COG1803	Methylglyoxal synthase
GRQ40_RS11690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GRQ40_RS11695	COG1694	Mazg nucleotide pyrophosphohydrolase
GRQ40_RS11700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GRQ40_RS11710	COG4347	Protein of unknown function (DUF1405)
GRQ40_RS11720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GRQ40_RS11740	COG0457	Tetratricopeptide repeat
GRQ40_RS11750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GRQ40_RS11755	COG0287	Prephenate dehydrogenase
GRQ40_RS11760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GRQ40_RS11765	COG0159	tryptophan synthase activity
GRQ40_RS11775	COG0135	phosphoribosylanthranilate isomerase activity
GRQ40_RS11780	COG0134	indole-3-glycerol-phosphate synthase activity
GRQ40_RS11785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GRQ40_RS11795	COG4401	Chorismate mutase type I
GRQ40_RS11800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GRQ40_RS11805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GRQ40_RS11810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GRQ40_RS11815	COG0105	UTP biosynthetic process
GRQ40_RS11825	COG2226	methyltransferase
GRQ40_RS11840	COG0302	gtp cyclohydrolase
GRQ40_RS11850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GRQ40_RS11865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GRQ40_RS11870	COG1160	GTP binding
GRQ40_RS11885	COG1304	FMN binding
GRQ40_RS11890	COG0539	negative regulation of cytoplasmic translation
GRQ40_RS11895	COG0204	Acyl-transferase
GRQ40_RS11900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GRQ40_RS11910	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GRQ40_RS11915	COG2959	enzyme of heme biosynthesis
GRQ40_RS11920	COG3409	Peptidoglycan-binding domain 1 protein
GRQ40_RS11920	COG3773	Cell wall hydrolase
GRQ40_RS11925	COG2339	peptidase activity
GRQ40_RS11935	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS11940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GRQ40_RS11945	COG1309	transcriptional regulator
GRQ40_RS11965	COG0492	ferredoxin-NADP+ reductase activity
GRQ40_RS11970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GRQ40_RS11980	COG1408	metallophosphoesterase
GRQ40_RS12000	COG3546	catalase activity
GRQ40_RS12015	COG1266	CAAX protease self-immunity
GRQ40_RS12020	COG0514	ATP-dependent DNA helicase (RecQ)
GRQ40_RS12040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GRQ40_RS12045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GRQ40_RS12055	COG1595	DNA-templated transcription, initiation
GRQ40_RS12070	COG2096	Adenosyltransferase
GRQ40_RS12085	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GRQ40_RS12095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GRQ40_RS12100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GRQ40_RS12105	COG1120	ATPase activity
GRQ40_RS12110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRQ40_RS12115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRQ40_RS12125	COG1132	(ABC) transporter
GRQ40_RS12130	COG0745	RESPONSE REGULATOR receiver
GRQ40_RS12135	COG5002	protein histidine kinase activity
GRQ40_RS12140	COG5002	protein histidine kinase activity
GRQ40_RS12145	COG0745	RESPONSE REGULATOR receiver
GRQ40_RS12150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GRQ40_RS12155	COG1333	cytochrome c biogenesis protein
GRQ40_RS12160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GRQ40_RS12165	COG1187	pseudouridine synthase activity
GRQ40_RS12170	COG0700	Nucleoside recognition
GRQ40_RS12175	COG2715	membrane protein required for spore maturation
GRQ40_RS12180	COG1686	Belongs to the peptidase S11 family
GRQ40_RS12185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GRQ40_RS12200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GRQ40_RS12205	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GRQ40_RS12210	COG1547	Domain of unknown function (DUF309)
GRQ40_RS12220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GRQ40_RS12225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GRQ40_RS12225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GRQ40_RS12230	COG0307	riboflavin synthase, alpha
GRQ40_RS12235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GRQ40_RS12235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GRQ40_RS12240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GRQ40_RS12245	COG4086	secreted protein
GRQ40_RS12255	COG0697	spore germination
GRQ40_RS12270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GRQ40_RS12295	COG2172	sigma factor antagonist activity
GRQ40_RS12300	COG1366	Belongs to the anti-sigma-factor antagonist family
GRQ40_RS12305	COG1686	Belongs to the peptidase S11 family
GRQ40_RS12325	COG4974	Belongs to the 'phage' integrase family
GRQ40_RS12335	COG0735	belongs to the Fur family
GRQ40_RS12340	COG1300	Membrane
GRQ40_RS12345	COG1379	DNA repair
GRQ40_RS12350	COG0494	nUDIX hydrolase
GRQ40_RS12355	COG0667	Aldo Keto reductase
GRQ40_RS12370	COG4918	Iron-sulphur cluster biosynthesis
GRQ40_RS12380	COG0300	oxidoreductase activity
GRQ40_RS12385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GRQ40_RS12390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GRQ40_RS12395	COG1902	pentaerythritol trinitrate reductase activity
GRQ40_RS12405	COG1234	tRNA 3'-trailer cleavage
GRQ40_RS12410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GRQ40_RS12415	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
GRQ40_RS12430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GRQ40_RS12445	COG2076	Multidrug Resistance protein
GRQ40_RS12455	COG2195	Cleaves the N-terminal amino acid of tripeptides
GRQ40_RS12465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GRQ40_RS12470	COG0346	lactoylglutathione lyase activity
GRQ40_RS12480	COG1376	ErfK ybiS ycfS ynhG family protein
GRQ40_RS12485	COG4129	membrane
GRQ40_RS12490	COG1126	abc transporter atp-binding protein
GRQ40_RS12495	COG0765	amino acid transport
GRQ40_RS12500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRQ40_RS12520	COG3620	sequence-specific DNA binding
GRQ40_RS12525	COG1703	isobutyryl-CoA mutase activity
GRQ40_RS12530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GRQ40_RS12530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GRQ40_RS12535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GRQ40_RS12540	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRQ40_RS12545	COG0022	dehydrogenase e1 component
GRQ40_RS12550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GRQ40_RS12555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GRQ40_RS12560	COG3426	butyrate kinase activity
GRQ40_RS12570	COG0280	phosphate acetyltransferase
GRQ40_RS12575	COG3290	protein histidine kinase activity
GRQ40_RS12575	COG3829	transcription factor binding
GRQ40_RS12585	COG0584	glycerophosphoryl diester phosphodiesterase
GRQ40_RS12590	COG3093	addiction module antidote protein HigA
GRQ40_RS12595	COG0492	ferredoxin-NADP+ reductase activity
GRQ40_RS12660	COG0582	viral genome integration into host DNA
GRQ40_RS12670	COG0750	zinc metalloprotease
GRQ40_RS12675	COG0497	DNA recombination
GRQ40_RS12680	COG1438	arginine binding
GRQ40_RS12685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GRQ40_RS12690	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GRQ40_RS12700	COG1722	exodeoxyribonuclease VII activity
GRQ40_RS12705	COG1570	exodeoxyribonuclease VII activity
GRQ40_RS12710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GRQ40_RS12715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GRQ40_RS12720	COG1302	Protein conserved in bacteria
GRQ40_RS12725	COG0439	Biotin carboxylase
GRQ40_RS12730	COG0511	ligase activity, forming carbon-carbon bonds
GRQ40_RS12770	COG3854	ATPases associated with a variety of cellular activities
GRQ40_RS12780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GRQ40_RS12785	COG0006	proline dipeptidase activity
GRQ40_RS12790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GRQ40_RS12800	COG3872	metal-dependent enzyme
GRQ40_RS12815	COG1752	Esterase of the alpha-beta hydrolase superfamily
GRQ40_RS12820	COG1321	iron dependent repressor
GRQ40_RS12830	COG3858	chitin binding
GRQ40_RS12830	COG1388	LysM domain
GRQ40_RS12830	COG3858	chitin binding
GRQ40_RS12830	COG1388	LysM domain
GRQ40_RS12855	COG0095	Lipoate-protein ligase
GRQ40_RS12860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GRQ40_RS12870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GRQ40_RS12875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GRQ40_RS12880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GRQ40_RS12920	COG4537	Required for transformation and DNA binding
GRQ40_RS12925	COG1459	type II secretion system
GRQ40_RS12930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GRQ40_RS12950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GRQ40_RS12965	COG0011	TIGRFAM Protein of
GRQ40_RS12975	COG1368	sulfuric ester hydrolase activity
GRQ40_RS12980	COG2368	4-hydroxyphenylacetate
GRQ40_RS12985	COG1940	carbohydrate kinase activity
GRQ40_RS12990	COG4483	Protein conserved in bacteria
GRQ40_RS13000	COG0697	spore germination
GRQ40_RS13010	COG0705	Rhomboid family
GRQ40_RS13010	COG0457	Tetratricopeptide repeat
GRQ40_RS13025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GRQ40_RS13030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GRQ40_RS13035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GRQ40_RS13050	COG0704	Plays a role in the regulation of phosphate uptake
GRQ40_RS13065	COG0477	Major facilitator Superfamily
GRQ40_RS13075	COG0840	transmembrane signaling receptor activity
GRQ40_RS13080	COG5521	maltodextrose utilization protein MalA
GRQ40_RS13085	COG3973	AAA domain
GRQ40_RS13090	COG0581	inorganic phosphate transmembrane transporter activity
GRQ40_RS13095	COG0573	inorganic phosphate transmembrane transporter activity
GRQ40_RS13100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GRQ40_RS13105	COG1388	LysM domain
GRQ40_RS13110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GRQ40_RS13115	COG4709	membrane
GRQ40_RS13120	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GRQ40_RS13125	COG0735	belongs to the Fur family
GRQ40_RS13130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GRQ40_RS13135	COG1121	(ABC) transporter
GRQ40_RS13145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GRQ40_RS13150	COG0513	Belongs to the DEAD box helicase family
GRQ40_RS13160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GRQ40_RS13165	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GRQ40_RS13170	COG2384	SAM-dependent methyltransferase
GRQ40_RS13175	COG2010	Cytochrome c
GRQ40_RS13185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GRQ40_RS13195	COG1671	Belongs to the UPF0178 family
GRQ40_RS13200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GRQ40_RS13205	COG0517	IMP dehydrogenase activity
GRQ40_RS13210	COG1381	Involved in DNA repair and RecF pathway recombination
GRQ40_RS13220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GRQ40_RS13225	COG0295	cytidine deaminase activity
GRQ40_RS13230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GRQ40_RS13235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GRQ40_RS13240	COG1702	phosphate starvation-inducible protein PhoH
GRQ40_RS13260	COG1610	YqeY-like protein
GRQ40_RS13265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GRQ40_RS13270	COG1283	sodium-dependent phosphate transmembrane transporter activity
GRQ40_RS13275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GRQ40_RS13280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GRQ40_RS13285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GRQ40_RS13290	COG2264	protein methyltransferase activity
GRQ40_RS13295	COG0484	heat shock protein binding
GRQ40_RS13300	COG0443	Heat shock 70 kDa protein
GRQ40_RS13305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GRQ40_RS13310	COG1420	regulation of RNA biosynthetic process
GRQ40_RS13315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GRQ40_RS13320	COG0481	GTPase activity
GRQ40_RS13330	COG0860	N-Acetylmuramoyl-L-alanine amidase
GRQ40_RS13335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GRQ40_RS13340	COG0268	Binds directly to 16S ribosomal RNA
GRQ40_RS13345	COG1466	dna polymerase III delta subunit
GRQ40_RS13355	COG2333	competence protein COMEC
GRQ40_RS13355	COG0658	competence protein
GRQ40_RS13360	COG2131	deaminase
GRQ40_RS13365	COG1555	photosystem II stabilization
GRQ40_RS13365	COG1596	polysaccharide export
GRQ40_RS13370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GRQ40_RS13375	COG2226	methyltransferase
GRQ40_RS13380	COG0799	negative regulation of ribosome biogenesis
GRQ40_RS13385	COG1713	HD superfamily hydrolase involved in NAD metabolism
GRQ40_RS13390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GRQ40_RS13395	COG1534	Rna-binding protein
GRQ40_RS13400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GRQ40_RS13405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GRQ40_RS13410	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GRQ40_RS13420	COG0688	phosphatidylethanolamine metabolic process
GRQ40_RS13425	COG1183	phosphatidylcholine synthase activity
GRQ40_RS13430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GRQ40_RS13435	COG1360	Flagellar Motor Protein
GRQ40_RS13450	COG0586	Pfam SNARE associated Golgi protein
GRQ40_RS13470	COG0626	cystathionine gamma-synthase activity
GRQ40_RS13475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GRQ40_RS13480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GRQ40_RS13485	COG2226	methyltransferase
GRQ40_RS13500	COG0768	penicillin binding
GRQ40_RS13505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GRQ40_RS13510	COG0572	uridine kinase
GRQ40_RS13530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GRQ40_RS13535	COG3906	Belongs to the UPF0473 family
GRQ40_RS13540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GRQ40_RS13545	COG4472	Bacterial protein of unknown function (DUF965)
GRQ40_RS13550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GRQ40_RS13555	COG0628	permease
GRQ40_RS13570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GRQ40_RS13580	COG0482	sulfurtransferase activity
GRQ40_RS13585	COG1104	cysteine desulfurase activity
GRQ40_RS13590	COG1959	2 iron, 2 sulfur cluster binding
GRQ40_RS13595	COG2364	Membrane
GRQ40_RS13600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GRQ40_RS13605	COG1309	transcriptional regulator
GRQ40_RS13615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GRQ40_RS13625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GRQ40_RS13630	COG0124	histidyl-tRNA synthetase
GRQ40_RS13635	COG0860	N-Acetylmuramoyl-L-alanine amidase
GRQ40_RS13635	COG3103	Sh3 type 3 domain protein
GRQ40_RS13635	COG4991	sh3 domain protein
GRQ40_RS13640	COG1490	D-aminoacyl-tRNA deacylase activity
GRQ40_RS13645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GRQ40_RS13650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GRQ40_RS13655	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GRQ40_RS13655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GRQ40_RS13660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GRQ40_RS13665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GRQ40_RS13665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GRQ40_RS13675	COG2244	polysaccharide biosynthetic process
GRQ40_RS13685	COG1862	Preprotein translocase
GRQ40_RS13690	COG0343	queuine tRNA-ribosyltransferase activity
GRQ40_RS13695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GRQ40_RS13705	COG2255	four-way junction helicase activity
GRQ40_RS13710	COG0632	four-way junction helicase activity
GRQ40_RS13725	COG0217	transcriptional regulatory protein
GRQ40_RS13735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GRQ40_RS13745	COG1388	LysM domain
GRQ40_RS13750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GRQ40_RS13755	COG0157	Belongs to the NadC ModD family
GRQ40_RS13760	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GRQ40_RS13765	COG1104	cysteine desulfurase activity
GRQ40_RS13770	COG1827	regulation of RNA biosynthetic process
GRQ40_RS13775	COG1968	undecaprenyl-diphosphatase activity
GRQ40_RS13795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GRQ40_RS13800	COG0789	Transcriptional regulator
GRQ40_RS13815	COG1285	pathogenesis
GRQ40_RS13860	COG0077	Prephenate dehydratase
GRQ40_RS13865	COG4492	Belongs to the UPF0735 family
GRQ40_RS13870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GRQ40_RS13875	COG3290	protein histidine kinase activity
GRQ40_RS13880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GRQ40_RS13885	COG2868	ribosomal protein
GRQ40_RS13890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GRQ40_RS13895	COG1994	Peptidase M50
GRQ40_RS13900	COG0739	heme binding
GRQ40_RS13905	COG2894	cell division
GRQ40_RS13910	COG0850	regulation of cytokinetic process
GRQ40_RS13915	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GRQ40_RS13920	COG1792	Involved in formation and maintenance of cell shape
GRQ40_RS13925	COG1077	Cell shape determining protein MreB Mrl
GRQ40_RS13930	COG2003	Belongs to the UPF0758 family
GRQ40_RS13935	COG0424	maF-like protein
GRQ40_RS13965	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GRQ40_RS13985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GRQ40_RS14030	COG0285	dihydrofolate synthase activity
GRQ40_RS14035	COG0525	valine-tRNA ligase activity
GRQ40_RS14050	COG1388	LysM domain
GRQ40_RS14050	COG1388	LysM domain
GRQ40_RS14055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GRQ40_RS14060	COG0113	porphobilinogen synthase activity
GRQ40_RS14065	COG1587	Uroporphyrinogen-III synthase
GRQ40_RS14070	COG0181	hydroxymethylbilane synthase activity
GRQ40_RS14075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GRQ40_RS14090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GRQ40_RS14095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GRQ40_RS14100	COG0470	DNA polymerase III
GRQ40_RS14100	COG1067	ATP-dependent peptidase activity
GRQ40_RS14105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GRQ40_RS14110	COG0544	peptidyl-prolyl cis-trans isomerase activity
GRQ40_RS14120	COG0066	3-isopropylmalate dehydratase activity
GRQ40_RS14125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GRQ40_RS14130	COG0473	3-isopropylmalate dehydrogenase activity
GRQ40_RS14135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GRQ40_RS14140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GRQ40_RS14145	COG0440	acetolactate synthase activity
GRQ40_RS14150	COG0028	Belongs to the TPP enzyme family
GRQ40_RS14155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GRQ40_RS14165	COG0622	Phosphoesterase
GRQ40_RS14170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GRQ40_RS14175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GRQ40_RS14180	COG5401	PFAM Sporulation and spore germination
GRQ40_RS14185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GRQ40_RS14190	COG1846	Transcriptional regulator
GRQ40_RS14195	COG2197	response regulator
GRQ40_RS14200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GRQ40_RS14205	COG1053	succinate dehydrogenase
GRQ40_RS14210	COG2009	succinate dehydrogenase
GRQ40_RS14215	COG1719	4-vinyl reductase, 4VR
GRQ40_RS14225	COG0322	excinuclease ABC activity
GRQ40_RS14255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GRQ40_RS14265	COG0431	NADPH-dependent FMN reductase
GRQ40_RS14270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GRQ40_RS14275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GRQ40_RS14280	COG1116	anion transmembrane transporter activity
GRQ40_RS14285	COG3118	belongs to the thioredoxin family
GRQ40_RS14290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GRQ40_RS14295	COG2086	electron transfer activity
GRQ40_RS14300	COG1024	Enoyl-CoA hydratase
GRQ40_RS14305	COG1309	transcriptional regulator
GRQ40_RS14310	COG0318	PFAM AMP-dependent synthetase and ligase
GRQ40_RS14315	COG3766	membrane
GRQ40_RS14320	COG1193	negative regulation of DNA recombination
GRQ40_RS14325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GRQ40_RS14325	COG1796	DNA polymerase
GRQ40_RS14330	COG1286	toxin biosynthetic process
GRQ40_RS14335	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GRQ40_RS14340	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GRQ40_RS14345	COG2409	Drug exporters of the RND superfamily
GRQ40_RS14345	COG1033	growth of symbiont in host cell
GRQ40_RS14350	COG1846	Transcriptional regulator
GRQ40_RS14355	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GRQ40_RS14360	COG1131	(ABC) transporter
GRQ40_RS14365	COG0072	phenylalanine-tRNA ligase activity
GRQ40_RS14365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRQ40_RS14370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GRQ40_RS14380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GRQ40_RS14395	COG2226	methyltransferase
GRQ40_RS14400	COG1363	Peptidase, m42
GRQ40_RS14415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GRQ40_RS14420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GRQ40_RS14430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GRQ40_RS14440	COG1484	DNA-dependent DNA replication
GRQ40_RS14445	COG3611	Membrane attachment protein
GRQ40_RS14450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GRQ40_RS14460	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GRQ40_RS14465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GRQ40_RS14470	COG0237	dephospho-CoA kinase activity
GRQ40_RS14475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GRQ40_RS14485	COG5002	protein histidine kinase activity
GRQ40_RS14490	COG0745	RESPONSE REGULATOR receiver
GRQ40_RS14500	COG0039	L-malate dehydrogenase activity
GRQ40_RS14505	COG0538	isocitrate dehydrogenase activity
GRQ40_RS14510	COG0372	Belongs to the citrate synthase family
GRQ40_RS14515	COG2707	UPF0756 membrane protein
GRQ40_RS14520	COG0628	permease
GRQ40_RS14535	COG0205	6-phosphofructokinase activity
GRQ40_RS14540	COG0825	malonyl-CoA metabolic process
GRQ40_RS14545	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GRQ40_RS14550	COG1725	Transcriptional regulator
GRQ40_RS14560	COG0281	malic enzyme
GRQ40_RS14565	COG0587	DNA-directed DNA polymerase activity
GRQ40_RS14580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GRQ40_RS14590	COG4109	DRTGG domain
GRQ40_RS14595	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GRQ40_RS14605	COG0006	proline dipeptidase activity
GRQ40_RS14615	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS14620	COG0589	response to stress
GRQ40_RS14625	COG0165	Argininosuccinate lyase
GRQ40_RS14630	COG0137	argininosuccinate synthase activity
GRQ40_RS14640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GRQ40_RS14645	COG0521	Mo-molybdopterin cofactor biosynthetic process
GRQ40_RS14650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GRQ40_RS14655	COG0827	DNA restriction-modification system
GRQ40_RS14660	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GRQ40_RS14665	COG3874	Sporulation protein YtfJ
GRQ40_RS14675	COG1714	RDD family
GRQ40_RS14680	COG0616	signal peptide processing
GRQ40_RS14685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GRQ40_RS14690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GRQ40_RS14700	COG0301	tRNA thio-modification
GRQ40_RS14705	COG1104	cysteine desulfurase activity
GRQ40_RS14710	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GRQ40_RS14715	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GRQ40_RS14720	COG1956	GAF domain-containing protein
GRQ40_RS14725	COG2199	diguanylate cyclase activity
GRQ40_RS14725	COG2203	Gaf domain
GRQ40_RS14730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GRQ40_RS14745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GRQ40_RS14750	COG0454	-acetyltransferase
GRQ40_RS14755	COG0517	IMP dehydrogenase activity
GRQ40_RS14760	COG0123	including yeast histone deacetylase and acetoin utilization protein
GRQ40_RS14770	COG1605	Chorismate mutase
GRQ40_RS14770	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GRQ40_RS14775	COG0849	cell division
GRQ40_RS14780	COG3118	belongs to the thioredoxin family
GRQ40_RS14790	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GRQ40_RS14795	COG2309	aminopeptidase activity
GRQ40_RS14800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GRQ40_RS14805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GRQ40_RS14810	COG1674	ftsk spoiiie
GRQ40_RS14810	COG1674	ftsk spoiiie
GRQ40_RS14815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRQ40_RS14820	COG4848	Belongs to the UPF0354 family
GRQ40_RS14825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GRQ40_RS14830	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GRQ40_RS14835	COG1363	Peptidase, m42
GRQ40_RS14850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GRQ40_RS14855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GRQ40_RS14865	COG0510	thiamine kinase activity
GRQ40_RS14870	COG1523	belongs to the glycosyl hydrolase 13 family
GRQ40_RS14880	COG1346	cytolysis
GRQ40_RS14885	COG1380	Effector of murein hydrolase LrgA
GRQ40_RS14900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GRQ40_RS14905	COG1349	DNA-binding transcription factor activity
GRQ40_RS14910	COG1187	pseudouridine synthase activity
GRQ40_RS14920	COG2244	polysaccharide biosynthetic process
GRQ40_RS14925	COG2081	HI0933 family
GRQ40_RS14945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GRQ40_RS14950	COG0495	leucyl-tRNA aminoacylation
GRQ40_RS14960	COG2814	Major facilitator Superfamily
GRQ40_RS14975	COG1242	4 iron, 4 sulfur cluster binding
GRQ40_RS14980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GRQ40_RS14990	COG2267	carboxylic ester hydrolase activity
GRQ40_RS14995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GRQ40_RS15000	COG4990	cell redox homeostasis
GRQ40_RS15005	COG0367	asparagine synthase
GRQ40_RS15010	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GRQ40_RS15015	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GRQ40_RS15020	COG3002	Belongs to the UPF0753 family
GRQ40_RS15025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GRQ40_RS15035	COG1506	peptidase
GRQ40_RS15040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GRQ40_RS15045	COG1116	anion transmembrane transporter activity
GRQ40_RS15050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GRQ40_RS15055	COG0494	nUDIX hydrolase
GRQ40_RS15060	COG5609	conserved protein (DUF2294)
GRQ40_RS15070	COG4824	toxin secretion phage lysis holin
GRQ40_RS15075	COG0783	Belongs to the Dps family
GRQ40_RS15085	COG1854	S-ribosylhomocysteine lyase activity
GRQ40_RS15090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GRQ40_RS15100	COG1271	oxidase subunit
GRQ40_RS15105	COG1294	oxidase, subunit
GRQ40_RS15135	COG0318	PFAM AMP-dependent synthetase and ligase
GRQ40_RS15140	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GRQ40_RS15145	COG0596	Alpha beta hydrolase
GRQ40_RS15150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GRQ40_RS15155	COG1169	isochorismate synthase
GRQ40_RS15160	COG1575	Belongs to the MenA family. Type 1 subfamily
GRQ40_RS15165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GRQ40_RS15175	COG0058	SHG alpha-glucan phosphorylase activity
GRQ40_RS15180	COG0297	glycogen (starch) synthase activity
GRQ40_RS15190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GRQ40_RS15200	COG1230	cation diffusion facilitator family transporter
GRQ40_RS15295	COG0697	spore germination
GRQ40_RS15300	COG1285	pathogenesis
GRQ40_RS15305	COG0840	transmembrane signaling receptor activity
GRQ40_RS15310	COG1181	Belongs to the D-alanine--D-alanine ligase family
GRQ40_RS15315	COG3227	Zinc metalloprotease (Elastase)
GRQ40_RS15330	COG1247	-acetyltransferase
GRQ40_RS15335	COG2814	Major facilitator Superfamily
GRQ40_RS15340	COG1405	negative regulation of cell septum assembly
GRQ40_RS15340	COG3012	SEC-C Motif Domain Protein
GRQ40_RS15355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GRQ40_RS15375	COG1396	sequence-specific DNA binding
GRQ40_RS15390	COG1979	alcohol dehydrogenase
GRQ40_RS15395	COG2155	Conserved Protein
GRQ40_RS15400	COG1098	S1 RNA binding domain
GRQ40_RS15410	COG0436	Aminotransferase
GRQ40_RS15415	COG1522	sequence-specific DNA binding
GRQ40_RS15425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GRQ40_RS15430	COG2032	superoxide dismutase activity
GRQ40_RS15440	COG5018	Exonuclease
GRQ40_RS15460	COG1268	BioY protein
GRQ40_RS15465	COG0306	phosphate transporter
GRQ40_RS15470	COG1392	Phosphate transport regulator
GRQ40_RS15475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GRQ40_RS15485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRQ40_RS15490	COG3584	3D domain protein
GRQ40_RS15510	COG1252	NADH dehydrogenase
GRQ40_RS15515	COG0492	ferredoxin-NADP+ reductase activity
GRQ40_RS15520	COG0316	Belongs to the HesB IscA family
GRQ40_RS15525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GRQ40_RS15540	COG1252	NADH dehydrogenase
GRQ40_RS15545	COG0697	spore germination
GRQ40_RS15550	COG4837	Protein of unknown function (DUF1462)
GRQ40_RS15555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GRQ40_RS15560	COG0083	homoserine kinase activity
GRQ40_RS15565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GRQ40_RS15570	COG0460	homoserine dehydrogenase
GRQ40_RS15575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GRQ40_RS15580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GRQ40_RS15585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GRQ40_RS15590	COG0647	UMP catabolic process
GRQ40_RS15600	COG2445	Protein of unknown function DUF86
GRQ40_RS15615	COG4470	Protein conserved in bacteria
GRQ40_RS15700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GRQ40_RS15705	COG0739	heme binding
GRQ40_RS15715	COG3377	Domain of unknown function (DUF1805)
GRQ40_RS15720	COG0737	Belongs to the 5'-nucleotidase family
GRQ40_RS15725	COG0730	response to heat
GRQ40_RS15730	COG1801	Protein of unknown function DUF72
GRQ40_RS15735	COG0719	Fe-S assembly protein
GRQ40_RS15740	COG0822	iron-sulfur transferase activity
GRQ40_RS15745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GRQ40_RS15750	COG0719	Fe-S assembly protein
GRQ40_RS15755	COG0396	ATPase activity
GRQ40_RS15760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GRQ40_RS15765	COG1464	Belongs to the NlpA lipoprotein family
GRQ40_RS15770	COG2011	ABC-type metal ion transport system permease component
GRQ40_RS15775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GRQ40_RS15790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GRQ40_RS15795	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GRQ40_RS15800	COG0509	glycine decarboxylation via glycine cleavage system
GRQ40_RS15805	COG1393	Belongs to the ArsC family
GRQ40_RS15810	COG1960	acyl-CoA dehydrogenase activity
GRQ40_RS15815	COG0183	Belongs to the thiolase family
GRQ40_RS15820	COG1024	Enoyl-CoA hydratase
GRQ40_RS15820	COG1250	3-hydroxyacyl-CoA dehydrogenase
GRQ40_RS15830	COG0506	proline dehydrogenase activity
GRQ40_RS15840	COG5577	PFAM Coat F domain
GRQ40_RS15850	COG0390	transport system, permease component
GRQ40_RS15865	COG0438	transferase activity, transferring glycosyl groups
GRQ40_RS15880	COG0463	Glycosyl transferase, family 2
GRQ40_RS15895	COG1028	Short-chain dehydrogenase reductase Sdr
GRQ40_RS15945	COG0778	Nitroreductase
GRQ40_RS15950	COG1132	(ABC) transporter
GRQ40_RS15975	COG1124	(ABC) transporter
GRQ40_RS15980	COG0444	Belongs to the ABC transporter superfamily
GRQ40_RS15985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GRQ40_RS15990	COG0601	transmembrane transport
GRQ40_RS15995	COG0747	negative chemotaxis
GRQ40_RS16015	COG0492	ferredoxin-NADP+ reductase activity
GRQ40_RS16025	COG1309	transcriptional regulator
GRQ40_RS16135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GRQ40_RS16140	COG0557	exoribonuclease II activity
GRQ40_RS16150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GRQ40_RS16155	COG0148	phosphopyruvate hydratase activity
GRQ40_RS16165	COG0149	triose-phosphate isomerase activity
GRQ40_RS16170	COG0126	phosphoglycerate kinase activity
GRQ40_RS16190	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GRQ40_RS16205	COG0740	serine-type endopeptidase activity
GRQ40_RS16210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRQ40_RS16215	COG1481	regulation of sporulation
GRQ40_RS16220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GRQ40_RS16225	COG1660	Displays ATPase and GTPase activities
GRQ40_RS16230	COG1051	belongs to the nudix hydrolase family
GRQ40_RS16235	COG0492	ferredoxin-NADP+ reductase activity
GRQ40_RS16240	COG0457	Tetratricopeptide repeat
GRQ40_RS16245	COG0140	phosphoribosyl-ATP diphosphatase activity
GRQ40_RS16245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GRQ40_RS16250	COG0107	imidazoleglycerol-phosphate synthase activity
GRQ40_RS16255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GRQ40_RS16260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GRQ40_RS16265	COG0131	Imidazoleglycerol-phosphate dehydratase
GRQ40_RS16270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GRQ40_RS16275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GRQ40_RS16280	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GRQ40_RS16285	COG0110	maltose O-acetyltransferase activity
GRQ40_RS16290	COG0546	phosphoglycolate phosphatase activity
GRQ40_RS16295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GRQ40_RS16300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GRQ40_RS16305	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GRQ40_RS16310	COG1950	PFAM Membrane protein of
GRQ40_RS16315	COG1983	PspC domain protein
GRQ40_RS16325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GRQ40_RS16330	COG0556	nucleotide-excision repair
GRQ40_RS16335	COG4897	Protein conserved in bacteria
GRQ40_RS16340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GRQ40_RS16345	COG0789	Transcriptional regulator
GRQ40_RS16355	COG0463	Glycosyl transferase, family 2
GRQ40_RS16365	COG0793	Belongs to the peptidase S41A family
GRQ40_RS16365	COG3409	Peptidoglycan-binding domain 1 protein
GRQ40_RS16375	COG0640	Transcriptional regulator
GRQ40_RS16385	COG1253	flavin adenine dinucleotide binding
GRQ40_RS16390	COG2738	Putative neutral zinc metallopeptidase
GRQ40_RS16395	COG0789	Transcriptional regulator
GRQ40_RS16400	COG3634	alkyl hydroperoxide reductase activity
GRQ40_RS16405	COG0450	alkyl hydroperoxide reductase
GRQ40_RS16480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GRQ40_RS16485	COG0798	PFAM Bile acid sodium symporter
GRQ40_RS16490	COG0640	Transcriptional regulator
GRQ40_RS16495	COG1247	-acetyltransferase
GRQ40_RS16540	COG0739	heme binding
GRQ40_RS16545	COG2177	Part of the ABC transporter FtsEX involved in
GRQ40_RS16550	COG2884	Cell division ATP-binding protein ftsE
GRQ40_RS16560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GRQ40_RS16570	COG0653	protein targeting
GRQ40_RS16595	COG1516	flagellar protein fliS
GRQ40_RS16600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GRQ40_RS16605	COG1334	flagellar protein FlaG
GRQ40_RS16610	COG0463	Glycosyl transferase, family 2
GRQ40_RS16610	COG0457	Tetratricopeptide repeat
GRQ40_RS16615	COG1091	dTDP-4-dehydrorhamnose reductase activity
GRQ40_RS16630	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GRQ40_RS16635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GRQ40_RS16655	COG1216	Glycosyl transferase, family 2
GRQ40_RS16660	COG0463	Glycosyl transferase, family 2
GRQ40_RS16665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GRQ40_RS16675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GRQ40_RS16680	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GRQ40_RS16690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GRQ40_RS16695	COG1256	bacterial-type flagellum assembly
GRQ40_RS16695	COG4786	Flagellar basal body rod
GRQ40_RS16705	COG2747	anti-sigma28 factor FlgM
GRQ40_RS16715	COG1728	Protein conserved in bacteria
GRQ40_RS16735	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GRQ40_RS16745	COG1307	EDD domain protein, DegV family
GRQ40_RS16750	COG2197	response regulator
GRQ40_RS16755	COG4585	Histidine kinase
GRQ40_RS16760	COG1739	Uncharacterized protein family UPF0029
GRQ40_RS16765	COG1316	TRANSCRIPTIONal
GRQ40_RS16770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GRQ40_RS16775	COG0728	peptidoglycan biosynthetic process
GRQ40_RS16790	COG0438	transferase activity, transferring glycosyl groups
GRQ40_RS16805	COG1404	Belongs to the peptidase S8 family
GRQ40_RS16810	COG4193	domain, Protein
GRQ40_RS16830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRQ40_RS16850	COG3764	Sortase (surface protein transpeptidase)
GRQ40_RS16855	COG2211	Major facilitator Superfamily
GRQ40_RS16860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GRQ40_RS16865	COG4521	taurine ABC transporter
GRQ40_RS16870	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GRQ40_RS16875	COG2175	clavaminate synthase activity
GRQ40_RS16880	COG2076	Multidrug Resistance protein
GRQ40_RS16895	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GRQ40_RS16900	COG4988	ABC transporter
GRQ40_RS16905	COG1294	oxidase, subunit
GRQ40_RS16910	COG1271	oxidase subunit
GRQ40_RS16930	COG0095	Lipoate-protein ligase
GRQ40_RS16955	COG0577	efflux transmembrane transporter activity
GRQ40_RS16960	COG1136	(ABC) transporter
GRQ40_RS16965	COG0642	Histidine kinase
GRQ40_RS16970	COG0745	RESPONSE REGULATOR receiver
GRQ40_RS16985	COG0583	DNA-binding transcription factor activity
GRQ40_RS16990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GRQ40_RS16995	COG3290	protein histidine kinase activity
GRQ40_RS16995	COG3829	transcription factor binding
GRQ40_RS17000	COG2376	Dihydroxyacetone kinase
GRQ40_RS17010	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GRQ40_RS17010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRQ40_RS17010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GRQ40_RS17015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRQ40_RS17020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GRQ40_RS17025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GRQ40_RS17035	COG0670	Belongs to the BI1 family
GRQ40_RS17060	COG2336	PFAM SpoVT AbrB
GRQ40_RS17085	COG3620	sequence-specific DNA binding
GRQ40_RS17140	COG4974	Belongs to the 'phage' integrase family
GRQ40_RS17155	COG2003	Belongs to the UPF0758 family
GRQ40_RS17165	COG0791	NLP P60 protein
GRQ40_RS17185	COG0653	protein targeting
GRQ40_RS17200	COG0728	peptidoglycan biosynthetic process
GRQ40_RS17215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GRQ40_RS17225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GRQ40_RS17230	COG1316	TRANSCRIPTIONal
GRQ40_RS17235	COG0791	NLP P60 protein
GRQ40_RS17235	COG1388	LysM domain
GRQ40_RS17245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GRQ40_RS17255	COG0629	single-stranded DNA binding
GRQ40_RS17265	COG3764	Sortase (surface protein transpeptidase)
GRQ40_RS17275	COG0527	aspartate kinase activity
GRQ40_RS17300	COG1012	belongs to the aldehyde dehydrogenase family
GRQ40_RS17315	COG3226	Transcriptional regulator
GRQ40_RS17320	COG0477	Major facilitator Superfamily
GRQ40_RS17325	COG1309	transcriptional regulator
GRQ40_RS17335	COG1940	carbohydrate kinase activity
GRQ40_RS17340	COG0673	inositol 2-dehydrogenase activity
GRQ40_RS17365	COG2200	EAL domain
GRQ40_RS17370	COG1879	ABC-type sugar transport system periplasmic component
GRQ40_RS17375	COG1172	Belongs to the binding-protein-dependent transport system permease family
GRQ40_RS17380	COG1129	ABC transporter
GRQ40_RS17385	COG1869	D-ribose catabolic process
GRQ40_RS17390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRQ40_RS17395	COG1609	Transcriptional regulator
GRQ40_RS17400	COG1482	cell wall glycoprotein biosynthetic process
GRQ40_RS17415	COG0395	ABC-type sugar transport system, permease component
GRQ40_RS17420	COG1175	transmembrane transport
GRQ40_RS17430	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
GRQ40_RS17435	COG1609	Transcriptional regulator
GRQ40_RS17440	COG0561	phosphatase activity
GRQ40_RS17455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GRQ40_RS17465	COG4786	Flagellar basal body rod
GRQ40_RS17470	COG4786	Flagellar basal body rod
GRQ40_RS17475	COG1077	Cell shape determining protein MreB Mrl
GRQ40_RS17480	COG1609	Transcriptional regulator
GRQ40_RS17490	COG0739	heme binding
GRQ40_RS17495	COG2385	sporulation resulting in formation of a cellular spore
GRQ40_RS17500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GRQ40_RS17510	COG4836	Membrane
GRQ40_RS17515	COG1007	ATP synthesis coupled electron transport
GRQ40_RS17520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRQ40_RS17525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GRQ40_RS17530	COG0713	ATP synthesis coupled electron transport
GRQ40_RS17535	COG0839	Belongs to the complex I subunit 6 family
GRQ40_RS17545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GRQ40_RS17550	COG0649	NAD binding
GRQ40_RS17555	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRQ40_RS17560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRQ40_RS17565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRQ40_RS17570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GRQ40_RS17575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GRQ40_RS17580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GRQ40_RS17585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GRQ40_RS17590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GRQ40_RS17595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GRQ40_RS17605	COG0356	it plays a direct role in the translocation of protons across the membrane
GRQ40_RS17620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GRQ40_RS17625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GRQ40_RS17630	COG4475	Protein of unknown function (DUF436)
GRQ40_RS17635	COG0698	ribose 5-phosphate isomerase
GRQ40_RS17640	COG0840	transmembrane signaling receptor activity
GRQ40_RS17650	COG1971	Probably functions as a manganese efflux pump
GRQ40_RS17655	COG0009	L-threonylcarbamoyladenylate synthase
GRQ40_RS17670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GRQ40_RS17680	COG1012	belongs to the aldehyde dehydrogenase family
GRQ40_RS17705	COG1435	thymidine kinase activity
GRQ40_RS17710	COG0254	rRNA binding
GRQ40_RS17715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GRQ40_RS17720	COG1494	fructose-1,6-bisphosphatase
GRQ40_RS17725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GRQ40_RS17730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GRQ40_RS17740	COG2204	response regulator
GRQ40_RS17745	COG4821	SIS domain
GRQ40_RS17750	COG0504	CTP synthase activity
GRQ40_RS17755	COG3343	RNA polymerase activity
GRQ40_RS17760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GRQ40_RS17760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GRQ40_RS17760	COG1703	isobutyryl-CoA mutase activity
GRQ40_RS17770	COG1960	acyl-CoA dehydrogenase activity
GRQ40_RS17775	COG1960	acyl-CoA dehydrogenase activity
GRQ40_RS17780	COG1250	3-hydroxyacyl-CoA dehydrogenase
GRQ40_RS17785	COG0183	Belongs to the thiolase family
GRQ40_RS17790	COG2181	nitrate reductase activity
GRQ40_RS17790	COG0247	lactate metabolic process
GRQ40_RS17795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GRQ40_RS17805	COG0018	arginyl-trna synthetase
GRQ40_RS17810	COG4506	Protein conserved in bacteria
GRQ40_RS17820	COG0010	Belongs to the arginase family
GRQ40_RS17830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GRQ40_RS17840	COG1994	Peptidase M50
GRQ40_RS17850	COG2252	PERMEase
GRQ40_RS17860	COG3465	dGTPase activity
GRQ40_RS17865	COG1078	dGTPase activity
GRQ40_RS17870	COG4844	belongs to the
GRQ40_RS17880	COG0095	Lipoate-protein ligase
GRQ40_RS17885	COG0280	phosphate acetyltransferase
GRQ40_RS17895	COG3773	Cell wall hydrolase
GRQ40_RS17905	COG2363	Small membrane protein
GRQ40_RS17920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GRQ40_RS17925	COG0423	glycine-tRNA ligase activity
GRQ40_RS17930	COG1216	Glycosyl transferase, family 2
GRQ40_RS17935	COG0697	spore germination
GRQ40_RS17940	COG0477	Major facilitator Superfamily
GRQ40_RS17945	COG4187	Peptidase family M20/M25/M40
GRQ40_RS17950	COG2508	Transcriptional regulator
GRQ40_RS17950	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GRQ40_RS17955	COG0686	Belongs to the AlaDH PNT family
GRQ40_RS17960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GRQ40_RS17970	COG0765	amino acid transport
GRQ40_RS17980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GRQ40_RS17990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GRQ40_RS18000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GRQ40_RS18020	COG0559	Belongs to the binding-protein-dependent transport system permease family
GRQ40_RS18035	COG0723	plastoquinol--plastocyanin reductase activity
GRQ40_RS18035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRQ40_RS18040	COG1115	amino acid carrier protein
GRQ40_RS18045	COG1929	Belongs to the glycerate kinase type-1 family
GRQ40_RS18050	COG3457	Alanine racemase
GRQ40_RS18070	COG2814	Major facilitator Superfamily
GRQ40_RS18075	COG1846	Transcriptional regulator
GRQ40_RS18080	COG0583	DNA-binding transcription factor activity
GRQ40_RS18085	COG0384	phenazine biosynthesis protein PhzF
GRQ40_RS18100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GRQ40_RS18105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GRQ40_RS18110	COG4853	Protein conserved in bacteria
GRQ40_RS18115	COG4863	YycH protein
GRQ40_RS18120	COG5002	protein histidine kinase activity
GRQ40_RS18125	COG0745	RESPONSE REGULATOR receiver
GRQ40_RS18130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GRQ40_RS18135	COG0305	Participates in initiation and elongation during chromosome replication
GRQ40_RS18140	COG0359	binds to the 23S rRNA
GRQ40_RS18145	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GRQ40_RS18150	COG4241	membrane
GRQ40_RS18155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GRQ40_RS18160	COG0629	single-stranded DNA binding
GRQ40_RS18165	COG0360	Binds together with S18 to 16S ribosomal RNA
GRQ40_RS18170	COG0012	GTP binding
GRQ40_RS18175	COG0243	molybdopterin cofactor binding
GRQ40_RS18180	COG4481	Protein conserved in bacteria
GRQ40_RS18185	COG0668	transmembrane transport
GRQ40_RS18200	COG1475	DNA binding
GRQ40_RS18205	COG1192	Involved in chromosome partitioning
GRQ40_RS18210	COG1475	DNA binding
GRQ40_RS18215	COG0357	Ribosomal RNA small subunit methyltransferase G
GRQ40_RS18220	COG0445	tRNA wobble uridine modification
GRQ40_RS18225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GRQ40_RS18230	COG1847	R3H domain protein
GRQ40_RS18235	COG0706	membrane insertase activity
GRQ40_RS18240	COG0594	ribonuclease P activity
GRQ40_RS18245	COG0230	Belongs to the bacterial ribosomal protein bL34 family