locus-tag	class	description
FK178_RS00015	COG0492	ferredoxin-NADP+ reductase activity
FK178_RS00020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK178_RS00040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FK178_RS00045	COG1185	polyribonucleotide nucleotidyltransferase activity
FK178_RS00050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FK178_RS00055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FK178_RS00060	COG0191	fructose-bisphosphate aldolase activity
FK178_RS00080	COG2226	methyltransferase
FK178_RS00085	COG0569	domain protein
FK178_RS00100	COG0436	Aminotransferase
FK178_RS00105	COG3239	Fatty acid desaturase
FK178_RS00115	COG3685	Protein conserved in bacteria
FK178_RS00120	COG0723	plastoquinol--plastocyanin reductase activity
FK178_RS00120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FK178_RS00145	COG2967	ApaG domain
FK178_RS00160	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FK178_RS00165	COG1805	sodium ion transport
FK178_RS00175	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FK178_RS00180	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FK178_RS00195	COG1477	protein flavinylation
FK178_RS00225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FK178_RS00255	COG0740	serine-type endopeptidase activity
FK178_RS00275	COG2066	Belongs to the glutaminase family
FK178_RS00280	COG3340	Belongs to the peptidase S51 family
FK178_RS00305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FK178_RS00315	COG3844	kynureninase activity
FK178_RS00345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK178_RS00350	COG3263	regulation of cellular component size
FK178_RS00370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FK178_RS00375	COG1663	tetraacyldisaccharide 4'-kinase activity
FK178_RS00385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FK178_RS00410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FK178_RS00415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FK178_RS00420	COG0436	Aminotransferase
FK178_RS00435	COG0525	valine-tRNA ligase activity
FK178_RS00445	COG0688	phosphatidylethanolamine metabolic process
FK178_RS00450	COG4589	Belongs to the CDS family
FK178_RS00460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK178_RS00465	COG0799	negative regulation of ribosome biogenesis
FK178_RS00470	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FK178_RS00470	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FK178_RS00480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FK178_RS00495	COG4771	TonB-dependent receptor
FK178_RS00500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FK178_RS00505	COG1181	Belongs to the D-alanine--D-alanine ligase family
FK178_RS00515	COG0564	pseudouridine synthase activity
FK178_RS00520	COG3022	response to hydroperoxide
FK178_RS00540	COG0159	tryptophan synthase activity
FK178_RS00545	COG0133	tryptophan synthase activity
FK178_RS00550	COG0135	phosphoribosylanthranilate isomerase activity
FK178_RS00555	COG0134	indole-3-glycerol-phosphate synthase activity
FK178_RS00560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FK178_RS00565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FK178_RS00565	COG0512	Glutamine amidotransferase of anthranilate synthase
FK178_RS00570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FK178_RS00585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FK178_RS00590	COG1404	Belongs to the peptidase S8 family
FK178_RS00605	COG2195	Cleaves the N-terminal amino acid of tripeptides
FK178_RS00610	COG0167	dihydroorotate dehydrogenase activity
FK178_RS00615	COG1280	lysine exporter protein (LysE YggA)
FK178_RS00630	COG1840	ABC-type Fe3 transport system, periplasmic component
FK178_RS00635	COG1176	ABC-type spermidine putrescine transport system, permease component I
FK178_RS00640	COG3842	ATPase activity
FK178_RS00645	COG0517	IMP dehydrogenase activity
FK178_RS00645	COG0516	GMP reductase activity
FK178_RS00670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK178_RS00675	COG0714	Associated with various cellular activities
FK178_RS00685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK178_RS00730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FK178_RS00735	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FK178_RS00760	COG3958	Transketolase
FK178_RS00770	COG0343	queuine tRNA-ribosyltransferase activity
FK178_RS00785	COG0825	malonyl-CoA metabolic process
FK178_RS00790	COG0305	Participates in initiation and elongation during chromosome replication
FK178_RS00805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FK178_RS00810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FK178_RS00815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FK178_RS00820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FK178_RS00875	COG0335	large ribosomal subunit rRNA binding
FK178_RS00880	COG0336	Belongs to the RNA methyltransferase TrmD family
FK178_RS00905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FK178_RS00915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FK178_RS00935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK178_RS00940	COG0824	Thioesterase
FK178_RS00945	COG1739	Uncharacterized protein family UPF0029
FK178_RS00950	COG0697	spore germination
FK178_RS00955	COG1011	Hydrolase
FK178_RS00960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK178_RS00960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK178_RS00970	COG2890	protein-(glutamine-N5) methyltransferase activity
FK178_RS00975	COG1611	Belongs to the LOG family
FK178_RS00985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FK178_RS00990	COG0737	Belongs to the 5'-nucleotidase family
FK178_RS00995	COG4085	toxin activity
FK178_RS00995	COG1525	nuclease
FK178_RS00995	COG0737	Belongs to the 5'-nucleotidase family
FK178_RS01010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FK178_RS01035	COG0497	DNA recombination
FK178_RS01040	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FK178_RS01075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FK178_RS01080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK178_RS01085	COG2176	DNA-directed DNA polymerase activity
FK178_RS01090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FK178_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK178_RS01105	COG0673	inositol 2-dehydrogenase activity
FK178_RS01110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FK178_RS01120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FK178_RS01140	COG0596	Alpha beta hydrolase
FK178_RS01145	COG0456	acetyltransferase
FK178_RS01150	COG0346	lactoylglutathione lyase activity
FK178_RS01155	COG1595	DNA-templated transcription, initiation
FK178_RS01160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FK178_RS01180	COG2514	catechol 2,3-dioxygenase activity
FK178_RS01200	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FK178_RS01220	COG0045	succinate-CoA ligase (ADP-forming) activity
FK178_RS01235	COG1085	galactose-1-phosphate uridylyltransferase
FK178_RS01240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FK178_RS01270	COG0702	epimerase
FK178_RS01275	COG1629	transport
FK178_RS01275	COG4206	TonB-dependent receptor
FK178_RS01290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK178_RS01295	COG1554	hydrolase, family 65, central catalytic
FK178_RS01300	COG0366	Alpha amylase catalytic
FK178_RS01305	COG1501	Belongs to the glycosyl hydrolase 31 family
FK178_RS01310	COG0366	Alpha amylase catalytic
FK178_RS01320	COG0205	6-phosphofructokinase activity
FK178_RS01335	COG0606	chelatase, subunit chli
FK178_RS01345	COG1914	H( )-stimulated, divalent metal cation uptake system
FK178_RS01355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FK178_RS01380	COG0642	Histidine kinase
FK178_RS01390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK178_RS01390	COG3153	acetyltransferase
FK178_RS01400	COG0137	argininosuccinate synthase activity
FK178_RS01405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FK178_RS01410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK178_RS01415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FK178_RS01420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FK178_RS01430	COG0165	Argininosuccinate lyase
FK178_RS01435	COG0129	dihydroxy-acid dehydratase activity
FK178_RS01440	COG0028	Belongs to the TPP enzyme family
FK178_RS01450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FK178_RS01460	COG0473	3-isopropylmalate dehydrogenase activity
FK178_RS01465	COG0066	3-isopropylmalate dehydratase activity
FK178_RS01470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FK178_RS01475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FK178_RS01485	COG0534	Mate efflux family protein
FK178_RS01490	COG0564	pseudouridine synthase activity
FK178_RS01495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FK178_RS01515	COG0443	Heat shock 70 kDa protein
FK178_RS01545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FK178_RS01555	COG2996	Protein conserved in bacteria
FK178_RS01580	COG0022	dehydrogenase e1 component
FK178_RS01590	COG1611	Belongs to the LOG family
FK178_RS01595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK178_RS01620	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FK178_RS01625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK178_RS01645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK178_RS01665	COG0668	transmembrane transport
FK178_RS01670	COG0783	Belongs to the Dps family
FK178_RS01705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FK178_RS01710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK178_RS01720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FK178_RS01725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FK178_RS01735	COG2244	polysaccharide biosynthetic process
FK178_RS01740	COG1086	Polysaccharide biosynthesis protein
FK178_RS01755	COG1028	Short-chain dehydrogenase reductase Sdr
FK178_RS01760	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
FK178_RS01775	COG2089	acid synthase
FK178_RS01795	COG1216	Glycosyl transferase, family 2
FK178_RS01795	COG0463	Glycosyl transferase, family 2
FK178_RS01820	COG0438	transferase activity, transferring glycosyl groups
FK178_RS01840	COG0367	asparagine synthase
FK178_RS01845	COG0463	Glycosyl transferase, family 2
FK178_RS01845	COG1216	Glycosyl transferase, family 2
FK178_RS01850	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FK178_RS01850	COG1215	transferase activity, transferring glycosyl groups
FK178_RS01855	COG0110	maltose O-acetyltransferase activity
FK178_RS01880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FK178_RS01885	COG0110	maltose O-acetyltransferase activity
FK178_RS01890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FK178_RS01920	COG4251	negative regulation of phosphorylation
FK178_RS01925	COG0784	Response regulator, receiver
FK178_RS01935	COG0784	Response regulator, receiver
FK178_RS01935	COG0643	Histidine kinase
FK178_RS01935	COG2198	Histidine kinase
FK178_RS01965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FK178_RS02000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FK178_RS02005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FK178_RS02010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FK178_RS02035	COG0339	signal peptide processing
FK178_RS02045	COG4251	negative regulation of phosphorylation
FK178_RS02065	COG4191	Histidine kinase
FK178_RS02070	COG1187	pseudouridine synthase activity
FK178_RS02080	COG0095	Lipoate-protein ligase
FK178_RS02090	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FK178_RS02130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FK178_RS02135	COG1611	Belongs to the LOG family
FK178_RS02145	COG1127	ABC transporter
FK178_RS02150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FK178_RS02175	COG1063	alcohol dehydrogenase
FK178_RS02200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK178_RS02205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK178_RS02215	COG0826	peptidase U32
FK178_RS02245	COG0730	response to heat
FK178_RS02250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FK178_RS02260	COG3258	Cytochrome c
FK178_RS02265	COG0737	Belongs to the 5'-nucleotidase family
FK178_RS02290	COG2223	nitrite transmembrane transporter activity
FK178_RS02295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK178_RS02295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FK178_RS02330	COG0312	modulator of DNA gyrase
FK178_RS02340	COG0714	Associated with various cellular activities
FK178_RS02395	COG4181	ATPase activity
FK178_RS02420	COG0745	RESPONSE REGULATOR receiver
FK178_RS02430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FK178_RS02435	COG0708	Exodeoxyribonuclease III
FK178_RS02450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FK178_RS02455	COG0745	RESPONSE REGULATOR receiver
FK178_RS02460	COG5002	protein histidine kinase activity
FK178_RS02465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK178_RS02485	COG2321	neutral zinc metallopeptidase
FK178_RS02495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK178_RS02505	COG0322	excinuclease ABC activity
FK178_RS02510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FK178_RS02515	COG0798	PFAM Bile acid sodium symporter
FK178_RS02525	COG2226	methyltransferase
FK178_RS02555	COG0300	oxidoreductase activity
FK178_RS02560	COG1012	belongs to the aldehyde dehydrogenase family
FK178_RS02595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FK178_RS02620	COG1476	TRANSCRIPTIONal
FK178_RS02710	COG0556	nucleotide-excision repair
FK178_RS02800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FK178_RS02870	COG4974	Belongs to the 'phage' integrase family
FK178_RS02875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FK178_RS02910	COG1702	phosphate starvation-inducible protein PhoH
FK178_RS02915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FK178_RS02920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK178_RS02935	COG4771	TonB-dependent receptor
FK178_RS02950	COG1363	Peptidase, m42
FK178_RS03000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FK178_RS03000	COG0116	Belongs to the methyltransferase superfamily
FK178_RS03015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FK178_RS03020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK178_RS03035	COG1629	transport
FK178_RS03045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FK178_RS03050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FK178_RS03060	COG1295	ribonuclease BN
FK178_RS03075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FK178_RS03080	COG3279	Response regulator of the LytR AlgR family
FK178_RS03085	COG0360	Binds together with S18 to 16S ribosomal RNA
FK178_RS03090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FK178_RS03095	COG0359	binds to the 23S rRNA
FK178_RS03110	COG0124	histidyl-tRNA synthetase
FK178_RS03145	COG1104	cysteine desulfurase activity
FK178_RS03170	COG1418	mRNA catabolic process
FK178_RS03175	COG0656	L-ascorbic acid biosynthetic process
FK178_RS03180	COG4974	Belongs to the 'phage' integrase family
FK178_RS03205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FK178_RS03215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK178_RS03225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK178_RS03245	COG2270	Major facilitator Superfamily
FK178_RS03270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FK178_RS03280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FK178_RS03290	COG0539	negative regulation of cytoplasmic translation
FK178_RS03290	COG2183	response to ionizing radiation
FK178_RS03295	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FK178_RS03300	COG0540	Belongs to the ATCase OTCase family
FK178_RS03310	COG1234	tRNA 3'-trailer cleavage
FK178_RS03315	COG2340	Cysteine-rich secretory protein family
FK178_RS03335	COG0259	pyridoxamine-phosphate oxidase activity
FK178_RS03345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FK178_RS03360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FK178_RS03395	COG3547	Transposase (IS116 IS110 IS902 family)
FK178_RS03435	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FK178_RS03440	COG0415	Belongs to the DNA photolyase family
FK178_RS03445	COG0300	oxidoreductase activity
FK178_RS03480	COG0424	maF-like protein
FK178_RS03490	COG2076	Multidrug Resistance protein
FK178_RS03505	COG1333	cytochrome c biogenesis protein
FK178_RS03505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FK178_RS03530	COG1393	Belongs to the ArsC family
FK178_RS03550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FK178_RS03555	COG1770	oligopeptidase
FK178_RS03565	COG0156	8-amino-7-oxononanoate synthase activity
FK178_RS03600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK178_RS03610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FK178_RS03625	COG0686	Belongs to the AlaDH PNT family
FK178_RS03635	COG0802	atpase or kinase
FK178_RS03645	COG1078	dGTPase activity
FK178_RS03655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FK178_RS03655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK178_RS03660	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK178_RS03665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FK178_RS03670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK178_RS03680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FK178_RS03685	COG1028	Short-chain dehydrogenase reductase Sdr
FK178_RS03700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FK178_RS03705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FK178_RS03710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FK178_RS03715	COG0131	Imidazoleglycerol-phosphate dehydratase
FK178_RS03720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FK178_RS03725	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FK178_RS03730	COG0107	imidazoleglycerol-phosphate synthase activity
FK178_RS03735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FK178_RS03735	COG0140	phosphoribosyl-ATP diphosphatase activity
FK178_RS03775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FK178_RS03795	COG0628	permease
FK178_RS03805	COG0753	catalase activity
FK178_RS03820	COG5002	protein histidine kinase activity
FK178_RS03820	COG3850	Histidine kinase
FK178_RS03845	COG0189	ligase activity
FK178_RS03860	COG1764	response to oxidative stress
FK178_RS03865	COG1047	Peptidyl-prolyl cis-trans
FK178_RS03870	COG0673	inositol 2-dehydrogenase activity
FK178_RS03885	COG5002	protein histidine kinase activity
FK178_RS03890	COG0745	RESPONSE REGULATOR receiver
FK178_RS03895	COG0671	phosphoesterase, PA-phosphatase related
FK178_RS03915	COG0527	aspartate kinase activity
FK178_RS03930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK178_RS03935	COG2259	Doxx family
FK178_RS03945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FK178_RS03965	COG0589	response to stress
FK178_RS03985	COG0513	Belongs to the DEAD box helicase family
FK178_RS03990	COG4628	conserved protein (DUF2132)
FK178_RS04010	COG1902	pentaerythritol trinitrate reductase activity
FK178_RS04015	COG0484	heat shock protein binding
FK178_RS04030	COG0697	spore germination
FK178_RS04040	COG0531	amino acid
FK178_RS04070	COG0736	holo-[acyl-carrier-protein] synthase activity
FK178_RS04075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK178_RS04085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK178_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
FK178_RS04095	COG3424	synthase
FK178_RS04105	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
FK178_RS04110	COG2885	chlorophyll binding
FK178_RS04125	COG0022	dehydrogenase e1 component
FK178_RS04145	COG0813	purine-nucleoside phosphorylase activity
FK178_RS04150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FK178_RS04165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FK178_RS04170	COG1193	negative regulation of DNA recombination
FK178_RS04175	COG3011	Protein conserved in bacteria
FK178_RS04180	COG1301	dicarboxylic acid transport
FK178_RS04185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FK178_RS04200	COG0247	lactate metabolic process
FK178_RS04200	COG0277	FAD linked oxidase domain protein
FK178_RS04215	COG1472	Belongs to the glycosyl hydrolase 3 family
FK178_RS04225	COG2181	nitrate reductase activity
FK178_RS04225	COG0247	lactate metabolic process
FK178_RS04230	COG0247	lactate metabolic process
FK178_RS04230	COG2181	nitrate reductase activity
FK178_RS04240	COG0860	N-Acetylmuramoyl-L-alanine amidase
FK178_RS04250	COG0251	oxidation-reduction process
FK178_RS04255	COG1803	Methylglyoxal synthase
FK178_RS04260	COG0205	6-phosphofructokinase activity
FK178_RS04270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FK178_RS04290	COG0628	permease
FK178_RS04300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FK178_RS04310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FK178_RS04335	COG1215	transferase activity, transferring glycosyl groups
FK178_RS04340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FK178_RS04360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK178_RS04365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK178_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
FK178_RS04420	COG4974	Belongs to the 'phage' integrase family
FK178_RS04455	COG0837	glucose binding
FK178_RS04465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FK178_RS04470	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FK178_RS04475	COG0813	purine-nucleoside phosphorylase activity
FK178_RS04500	COG3447	MASE1 domain protein
FK178_RS04500	COG5002	protein histidine kinase activity
FK178_RS04500	COG5001	Diguanylate cyclase
FK178_RS04515	COG0189	ligase activity
FK178_RS04545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK178_RS04555	COG2706	6-phosphogluconolactonase activity
FK178_RS04560	COG0598	Magnesium transport protein CorA
FK178_RS04570	COG0101	tRNA pseudouridine synthase activity
FK178_RS04575	COG1061	Type III restriction enzyme res subunit
FK178_RS04580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK178_RS04595	COG1045	serine acetyltransferase
FK178_RS04605	COG1289	transmembrane transporter activity
FK178_RS04610	COG2130	NADP-dependent
FK178_RS04620	COG1028	Short-chain dehydrogenase reductase Sdr
FK178_RS04655	COG2814	Major facilitator Superfamily
FK178_RS04660	COG0668	transmembrane transport
FK178_RS04680	COG1012	belongs to the aldehyde dehydrogenase family
FK178_RS04705	COG1480	7TM receptor with intracellular HD hydrolase
FK178_RS04710	COG0183	Belongs to the thiolase family
FK178_RS04720	COG3063	Type IV pilus biogenesis stability protein PilW
FK178_RS04725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FK178_RS04730	COG0542	response to heat
FK178_RS04740	COG2986	histidine ammonia-lyase
FK178_RS04745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FK178_RS04750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FK178_RS04760	COG2154	pterin-4-alpha-carbinolamine dehydratase
FK178_RS04765	COG0217	transcriptional regulatory protein
FK178_RS04780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FK178_RS04790	COG0693	protein deglycase activity
FK178_RS04825	COG1970	mechanosensitive ion channel activity
FK178_RS04845	COG0012	GTP binding
FK178_RS04855	COG0857	belongs to the CobB CobQ family
FK178_RS04855	COG0280	phosphate acetyltransferase
FK178_RS04860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FK178_RS04885	COG1640	4-alpha-glucanotransferase
FK178_RS04905	COG0366	Alpha amylase catalytic
FK178_RS04915	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FK178_RS04920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK178_RS04930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FK178_RS04935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK178_RS04955	COG4206	TonB-dependent receptor
FK178_RS04965	COG0302	gtp cyclohydrolase
FK178_RS04970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FK178_RS04980	COG1136	(ABC) transporter
FK178_RS04995	COG5002	protein histidine kinase activity
FK178_RS04995	COG2205	protein histidine kinase activity
FK178_RS04995	COG0784	Response regulator, receiver
FK178_RS05005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FK178_RS05025	COG1234	tRNA 3'-trailer cleavage
FK178_RS05035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FK178_RS05055	COG0514	ATP-dependent DNA helicase (RecQ)
FK178_RS05060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FK178_RS05070	COG1678	Uncharacterized ACR, COG1678
FK178_RS05100	COG2116	formate transmembrane transporter activity
FK178_RS05115	COG4771	TonB-dependent receptor
FK178_RS05155	COG2217	Heavy metal translocating P-type atpase
FK178_RS05170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK178_RS05180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FK178_RS05200	COG0347	Belongs to the P(II) protein family
FK178_RS05235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FK178_RS05260	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK178_RS05315	COG2132	Multicopper oxidase
FK178_RS05355	COG0640	Transcriptional regulator
FK178_RS05375	COG0347	Belongs to the P(II) protein family
FK178_RS05400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK178_RS05420	COG0531	amino acid
FK178_RS05425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK178_RS05445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FK178_RS05490	COG0860	N-Acetylmuramoyl-L-alanine amidase
FK178_RS05490	COG2247	cell wall binding repeat
FK178_RS05545	COG0464	growth
FK178_RS05570	COG2003	Belongs to the UPF0758 family
FK178_RS05575	COG0629	single-stranded DNA binding
FK178_RS05640	COG0438	transferase activity, transferring glycosyl groups
FK178_RS05655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FK178_RS05695	COG4206	TonB-dependent receptor
FK178_RS05705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FK178_RS05710	COG1120	ATPase activity
FK178_RS05730	COG1607	acyl-coa hydrolase
FK178_RS05740	COG2363	Small membrane protein
FK178_RS05750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FK178_RS05755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FK178_RS05785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FK178_RS05795	COG0254	rRNA binding
FK178_RS05805	COG0463	Glycosyl transferase, family 2
FK178_RS05810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK178_RS05815	COG1132	(ABC) transporter
FK178_RS05840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FK178_RS05840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FK178_RS05855	COG1022	Amp-dependent synthetase and ligase
FK178_RS05860	COG0667	Aldo Keto reductase
FK178_RS05870	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK178_RS05870	COG1024	Enoyl-CoA hydratase
FK178_RS05880	COG0183	Belongs to the thiolase family
FK178_RS05885	COG1960	acyl-CoA dehydrogenase activity
FK178_RS05890	COG3387	PFAM Glycoside hydrolase 15-related
FK178_RS05940	COG4771	TonB-dependent receptor
FK178_RS05945	COG0702	epimerase
FK178_RS05985	COG2211	Major facilitator Superfamily
FK178_RS05990	COG0673	inositol 2-dehydrogenase activity
FK178_RS06015	COG1595	DNA-templated transcription, initiation
FK178_RS06075	COG0714	Associated with various cellular activities
FK178_RS06110	COG1695	Transcriptional regulator
FK178_RS06130	COG0492	ferredoxin-NADP+ reductase activity
FK178_RS06135	COG2860	membrane
FK178_RS06150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FK178_RS06155	COG0439	Biotin carboxylase
FK178_RS06165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK178_RS06180	COG0730	response to heat
FK178_RS06190	COG1272	protein, Hemolysin III
FK178_RS06200	COG0420	3'-5' exonuclease activity
FK178_RS06205	COG0419	ATPase involved in DNA repair
FK178_RS06215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FK178_RS06220	COG2133	pyrroloquinoline quinone binding
FK178_RS06230	COG1570	exodeoxyribonuclease VII activity
FK178_RS06245	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FK178_RS06280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FK178_RS06285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FK178_RS06295	COG4651	solute:proton antiporter activity
FK178_RS06295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FK178_RS06300	COG2135	peptidase activity
FK178_RS06315	COG0346	lactoylglutathione lyase activity
FK178_RS06320	COG2353	YceI-like domain
FK178_RS06335	COG5507	3-demethylubiquinone-9 3-methyltransferase
FK178_RS06370	COG3547	Transposase (IS116 IS110 IS902 family)
FK178_RS06385	COG4974	Belongs to the 'phage' integrase family
FK178_RS06420	COG4771	TonB-dependent receptor
FK178_RS06430	COG0745	RESPONSE REGULATOR receiver
FK178_RS06455	COG0784	Response regulator, receiver
FK178_RS06455	COG2205	protein histidine kinase activity
FK178_RS06475	COG0823	Involved in the tonB-independent uptake of proteins
FK178_RS06480	COG4974	Belongs to the 'phage' integrase family
FK178_RS06490	COG2133	pyrroloquinoline quinone binding
FK178_RS06495	COG2010	Cytochrome c
FK178_RS06500	COG0572	uridine kinase
FK178_RS06510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK178_RS06515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK178_RS06515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK178_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
FK178_RS06525	COG1192	Involved in chromosome partitioning
FK178_RS06530	COG1475	DNA binding
FK178_RS06540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FK178_RS06570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FK178_RS06580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FK178_RS06590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FK178_RS06605	COG0105	UTP biosynthetic process
FK178_RS06615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FK178_RS06625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FK178_RS06630	COG2195	Cleaves the N-terminal amino acid of tripeptides
FK178_RS06640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FK178_RS06650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK178_RS06655	COG0501	Belongs to the peptidase M48B family
FK178_RS06670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FK178_RS06690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK178_RS06710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FK178_RS06730	COG3956	TIGRFAM MazG family protein
FK178_RS06745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FK178_RS06780	COG0438	transferase activity, transferring glycosyl groups
FK178_RS06785	COG0009	L-threonylcarbamoyladenylate synthase
FK178_RS06790	COG0617	tRNA 3'-terminal CCA addition
FK178_RS06795	COG1612	heme a metabolic process
FK178_RS06815	COG1131	(ABC) transporter
FK178_RS06835	COG0556	nucleotide-excision repair
FK178_RS06845	COG0071	Belongs to the small heat shock protein (HSP20) family
FK178_RS06875	COG0037	tRNA processing
FK178_RS06880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FK178_RS06900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK178_RS06920	COG1757	Na H antiporter
FK178_RS06925	COG0450	alkyl hydroperoxide reductase
FK178_RS06950	COG1674	ftsk spoiiie
FK178_RS06965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FK178_RS06965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FK178_RS06975	COG2949	membrane
FK178_RS06985	COG0561	phosphatase activity
FK178_RS07000	COG1278	Cold shock
FK178_RS07015	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FK178_RS07025	COG0504	CTP synthase activity
FK178_RS07030	COG0706	membrane insertase activity
FK178_RS07035	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FK178_RS07045	COG0482	sulfurtransferase activity
FK178_RS07070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK178_RS07070	COG0519	Catalyzes the synthesis of GMP from XMP
FK178_RS07085	COG1629	transport
FK178_RS07085	COG4206	TonB-dependent receptor
FK178_RS07095	COG3275	phosphorelay sensor kinase activity
FK178_RS07105	COG3279	Response regulator of the LytR AlgR family
FK178_RS07120	COG0626	cystathionine gamma-synthase activity
FK178_RS07125	COG1228	amidohydrolase
FK178_RS07145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FK178_RS07160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FK178_RS07180	COG0542	response to heat
FK178_RS07185	COG3237	CsbD-like
FK178_RS07200	COG0513	Belongs to the DEAD box helicase family
FK178_RS07205	COG0488	(ABC) transporter
FK178_RS07220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FK178_RS07250	COG1266	CAAX protease self-immunity
FK178_RS07255	COG4948	Mandelate Racemase Muconate Lactonizing
FK178_RS07260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FK178_RS07265	COG1575	Belongs to the MenA family. Type 1 subfamily
FK178_RS07290	COG0009	L-threonylcarbamoyladenylate synthase
FK178_RS07305	COG1473	amidohydrolase
FK178_RS07330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FK178_RS07365	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FK178_RS07385	COG0488	(ABC) transporter
FK178_RS07395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FK178_RS07400	COG0300	oxidoreductase activity
FK178_RS07420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FK178_RS07425	COG3942	CHAP domain
FK178_RS07425	COG1388	LysM domain
FK178_RS07430	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FK178_RS07445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FK178_RS07470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FK178_RS07495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FK178_RS07505	COG1160	GTP binding
FK178_RS07510	COG0655	NAD(P)H dehydrogenase (quinone) activity
FK178_RS07515	COG0673	inositol 2-dehydrogenase activity
FK178_RS07530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FK178_RS07550	COG0545	Peptidyl-prolyl cis-trans isomerase
FK178_RS07565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FK178_RS07570	COG0704	Plays a role in the regulation of phosphate uptake
FK178_RS07575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FK178_RS07580	COG0581	inorganic phosphate transmembrane transporter activity
FK178_RS07585	COG0573	inorganic phosphate transmembrane transporter activity
FK178_RS07590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FK178_RS07605	COG1064	alcohol dehydrogenase
FK178_RS07620	COG0110	maltose O-acetyltransferase activity
FK178_RS07625	COG2234	aminopeptidase activity
FK178_RS07630	COG0076	glutamate decarboxylase activity
FK178_RS07635	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FK178_RS07680	COG1830	Aldolase
FK178_RS07690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FK178_RS07710	COG0154	amidase activity
FK178_RS07715	COG0552	protein localization to endoplasmic reticulum
FK178_RS07725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FK178_RS07730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FK178_RS07735	COG1546	Belongs to the CinA family
FK178_RS07735	COG1058	Belongs to the CinA family
FK178_RS07745	COG0179	Fumarylacetoacetate (FAA) hydrolase
FK178_RS07755	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK178_RS07760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FK178_RS07765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK178_RS07780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FK178_RS07785	COG1506	peptidase
FK178_RS07800	COG0326	Molecular chaperone. Has ATPase activity
FK178_RS07805	COG3437	response regulator, receiver
FK178_RS07805	COG2205	protein histidine kinase activity
FK178_RS07805	COG4999	Histidine kinase
FK178_RS07805	COG3850	Histidine kinase
FK178_RS07845	COG0561	phosphatase activity
FK178_RS07870	COG1482	cell wall glycoprotein biosynthetic process
FK178_RS07875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FK178_RS07885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FK178_RS07890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FK178_RS07920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FK178_RS07925	COG0085	RNA polymerase activity
FK178_RS07930	COG0222	ribosome binding
FK178_RS07935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FK178_RS07940	COG0081	regulation of translation
FK178_RS07945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FK178_RS07965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FK178_RS07995	COG4974	Belongs to the 'phage' integrase family
FK178_RS08000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FK178_RS08005	COG1960	acyl-CoA dehydrogenase activity
FK178_RS08015	COG1115	amino acid carrier protein
FK178_RS08055	COG0577	efflux transmembrane transporter activity
FK178_RS08060	COG3876	Protein conserved in bacteria
FK178_RS08075	COG2890	protein-(glutamine-N5) methyltransferase activity
FK178_RS08085	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FK178_RS08115	COG1217	gtp-binding protein TYPA
FK178_RS08125	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FK178_RS08130	COG0668	transmembrane transport
FK178_RS08150	COG1629	transport
FK178_RS08160	COG3852	Histidine kinase
FK178_RS08175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK178_RS08200	COG2353	YceI-like domain
FK178_RS08215	COG2353	YceI-like domain
FK178_RS08225	COG1741	Belongs to the pirin family
FK178_RS08255	COG1862	Preprotein translocase
FK178_RS08265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FK178_RS08275	COG1132	(ABC) transporter
FK178_RS08305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK178_RS08320	COG0450	alkyl hydroperoxide reductase
FK178_RS08330	COG0514	ATP-dependent DNA helicase (RecQ)
FK178_RS08335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FK178_RS08335	COG0517	IMP dehydrogenase activity
FK178_RS08340	COG0805	protein transport
FK178_RS08345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FK178_RS08355	COG1137	ATPase activity
FK178_RS08360	COG2852	Protein conserved in bacteria
FK178_RS08370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FK178_RS08375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FK178_RS08380	COG0438	transferase activity, transferring glycosyl groups
FK178_RS08445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK178_RS08450	COG1083	cytidylyl-transferase
FK178_RS08465	COG2089	acid synthase
FK178_RS08480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FK178_RS08485	COG1216	Glycosyl transferase, family 2
FK178_RS08485	COG0463	Glycosyl transferase, family 2
FK178_RS08495	COG1216	Glycosyl transferase, family 2
FK178_RS08500	COG0438	transferase activity, transferring glycosyl groups
FK178_RS08505	COG1216	Glycosyl transferase, family 2
FK178_RS08515	COG1216	Glycosyl transferase, family 2
FK178_RS08515	COG0463	Glycosyl transferase, family 2
FK178_RS08530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK178_RS08535	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FK178_RS08575	COG4771	TonB-dependent receptor
FK178_RS08585	COG0612	Peptidase, M16
FK178_RS08610	COG0156	8-amino-7-oxononanoate synthase activity
FK178_RS08625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK178_RS08630	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FK178_RS08640	COG0489	protein tyrosine kinase activity
FK178_RS08640	COG3206	protein involved in exopolysaccharide biosynthesis
FK178_RS08660	COG0488	(ABC) transporter
FK178_RS08675	COG1136	(ABC) transporter
FK178_RS08695	COG0653	protein targeting
FK178_RS08730	COG1764	response to oxidative stress
FK178_RS08740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK178_RS08755	COG0671	phosphoesterase, PA-phosphatase related
FK178_RS08775	COG2326	polyphosphate kinase activity
FK178_RS08795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FK178_RS08795	COG3264	Mechanosensitive ion channel
FK178_RS08800	COG1668	transmembrane transport
FK178_RS08805	COG4152	abc transporter atp-binding protein
FK178_RS08810	COG0484	heat shock protein binding
FK178_RS08815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FK178_RS08825	COG1090	epimerase
FK178_RS08830	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FK178_RS08830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FK178_RS08840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FK178_RS08865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FK178_RS08885	COG0513	Belongs to the DEAD box helicase family
FK178_RS08890	COG2226	methyltransferase
FK178_RS08895	COG1595	DNA-templated transcription, initiation
FK178_RS08900	COG1522	sequence-specific DNA binding
FK178_RS08910	COG2095	MarC family integral membrane protein
FK178_RS08915	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK178_RS08915	COG1703	isobutyryl-CoA mutase activity
FK178_RS08915	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK178_RS08930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FK178_RS08935	COG0284	orotidine-5'-phosphate decarboxylase activity
FK178_RS08940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FK178_RS08950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FK178_RS08985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FK178_RS08990	COG0655	NAD(P)H dehydrogenase (quinone) activity
FK178_RS09000	COG1690	Belongs to the RtcB family
FK178_RS09005	COG0673	inositol 2-dehydrogenase activity
FK178_RS09010	COG1115	amino acid carrier protein
FK178_RS09040	COG3150	esterase
FK178_RS09060	COG2264	protein methyltransferase activity
FK178_RS09065	COG0149	triose-phosphate isomerase activity
FK178_RS09080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FK178_RS09085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FK178_RS09090	COG1132	(ABC) transporter
FK178_RS09095	COG0101	tRNA pseudouridine synthase activity
FK178_RS09130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FK178_RS09135	COG2197	response regulator
FK178_RS09140	COG0358	DNA primase activity
FK178_RS09175	COG3119	arylsulfatase activity
FK178_RS09185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK178_RS09220	COG0702	epimerase
FK178_RS09225	COG4771	TonB-dependent receptor
FK178_RS09235	COG3119	arylsulfatase activity
FK178_RS09245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FK178_RS09250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FK178_RS09280	COG1490	D-aminoacyl-tRNA deacylase activity
FK178_RS09285	COG1162	GTPase activity
FK178_RS09295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FK178_RS09305	COG0436	Aminotransferase
FK178_RS09310	COG1605	Chorismate mutase
FK178_RS09310	COG0077	Prephenate dehydratase
FK178_RS09330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FK178_RS09355	COG0527	aspartate kinase activity
FK178_RS09355	COG0460	homoserine dehydrogenase
FK178_RS09360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FK178_RS09370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FK178_RS09375	COG1960	acyl-CoA dehydrogenase activity
FK178_RS09380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FK178_RS09385	COG0589	response to stress
FK178_RS09445	COG1228	amidohydrolase
FK178_RS09460	COG1428	Deoxynucleoside kinase
FK178_RS09480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FK178_RS09495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FK178_RS09510	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK178_RS09510	COG0022	dehydrogenase e1 component
FK178_RS09515	COG2086	electron transfer activity
FK178_RS09520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FK178_RS09530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FK178_RS09535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FK178_RS09550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK178_RS09575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FK178_RS09590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FK178_RS09630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK178_RS09635	COG0587	DNA-directed DNA polymerase activity
FK178_RS09665	COG5002	protein histidine kinase activity
FK178_RS09715	COG0612	Peptidase, M16
FK178_RS09780	COG3179	chitinase
FK178_RS09795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FK178_RS09810	COG0492	ferredoxin-NADP+ reductase activity
FK178_RS09835	COG1428	Deoxynucleoside kinase
FK178_RS09865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FK178_RS09870	COG0659	secondary active sulfate transmembrane transporter activity
FK178_RS09900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FK178_RS09905	COG0569	domain protein
FK178_RS09910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FK178_RS09955	COG0488	(ABC) transporter
FK178_RS09985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK178_RS10005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FK178_RS10010	COG2204	response regulator
FK178_RS10030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FK178_RS10040	COG0459	protein refolding
FK178_RS10085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FK178_RS10095	COG0544	peptidyl-prolyl cis-trans isomerase activity
FK178_RS10100	COG1950	PFAM Membrane protein of
FK178_RS10115	COG0596	Alpha beta hydrolase
FK178_RS10120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FK178_RS10130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FK178_RS10140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FK178_RS10160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FK178_RS10185	COG0668	transmembrane transport
FK178_RS10190	COG1214	PFAM Peptidase M22, glycoprotease
FK178_RS10195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK178_RS10210	COG2322	membrane
FK178_RS10215	COG1999	signal sequence binding
FK178_RS10235	COG1845	cytochrome c oxidase, subunit III
FK178_RS10240	COG0109	protoheme IX farnesyltransferase activity
FK178_RS10270	COG2353	YceI-like domain
FK178_RS10280	COG3279	Response regulator of the LytR AlgR family
FK178_RS10290	COG0038	chloride channel
FK178_RS10300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK178_RS10330	COG0509	glycine decarboxylation via glycine cleavage system
FK178_RS10340	COG0632	four-way junction helicase activity
FK178_RS10345	COG0280	phosphate acetyltransferase
FK178_RS10345	COG0281	malic enzyme
FK178_RS10355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FK178_RS10370	COG2255	four-way junction helicase activity
FK178_RS10375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FK178_RS10405	COG0437	4 iron, 4 sulfur cluster binding
FK178_RS10420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FK178_RS10425	COG0195	Participates in both transcription termination and antitermination
FK178_RS10430	COG0779	Required for maturation of 30S ribosomal subunits
FK178_RS10435	COG0589	response to stress
FK178_RS10460	COG5002	protein histidine kinase activity
FK178_RS10460	COG3850	Histidine kinase
FK178_RS10490	COG2217	Heavy metal translocating P-type atpase
FK178_RS10500	COG1252	NADH dehydrogenase
FK178_RS10505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FK178_RS10540	COG2010	Cytochrome c
FK178_RS10545	COG0348	domain, Protein
FK178_RS10575	COG0427	acetyl-CoA hydrolase
FK178_RS10580	COG3118	belongs to the thioredoxin family
FK178_RS10585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK178_RS10600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK178_RS10620	COG0285	dihydrofolate synthase activity
FK178_RS10630	COG0848	biopolymer transport protein
FK178_RS10635	COG0811	peptide transport
FK178_RS10645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FK178_RS10650	COG1960	acyl-CoA dehydrogenase activity
FK178_RS10695	COG1629	transport
FK178_RS10705	COG4771	TonB-dependent receptor
FK178_RS10710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FK178_RS10720	COG0321	lipoyl(octanoyl) transferase activity
FK178_RS10725	COG0401	homolog of Blt101
FK178_RS10730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FK178_RS10760	COG2217	Heavy metal translocating P-type atpase
FK178_RS10795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK178_RS10810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK178_RS10840	COG0138	bifunctional purine biosynthesis protein purh
FK178_RS10845	COG1077	Cell shape determining protein MreB Mrl
FK178_RS10865	COG0772	Belongs to the SEDS family
FK178_RS10875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FK178_RS10885	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK178_RS10895	COG0658	competence protein
FK178_RS10895	COG2333	competence protein COMEC
FK178_RS10910	COG3104	oligopeptide transport
FK178_RS10915	COG0823	Involved in the tonB-independent uptake of proteins
FK178_RS10915	COG1506	peptidase
FK178_RS10930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK178_RS10935	COG1253	flavin adenine dinucleotide binding
FK178_RS10960	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FK178_RS10970	COG2223	nitrite transmembrane transporter activity
FK178_RS10985	COG5002	protein histidine kinase activity
FK178_RS10995	COG4242	Belongs to the peptidase S51 family
FK178_RS11000	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FK178_RS11005	COG4771	TonB-dependent receptor
FK178_RS11025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FK178_RS11030	COG2226	methyltransferase
FK178_RS11035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK178_RS11045	COG0463	Glycosyl transferase, family 2
FK178_RS11050	COG1215	transferase activity, transferring glycosyl groups
FK178_RS11065	COG2824	Alkylphosphonate utilization operon protein PhnA
FK178_RS11090	COG3665	Urea carboxylase-associated protein
FK178_RS11095	COG2808	Putative FMN-binding domain
FK178_RS11105	COG4095	Psort location CytoplasmicMembrane, score
FK178_RS11115	COG1028	Short-chain dehydrogenase reductase Sdr
FK178_RS11120	COG0584	glycerophosphoryl diester phosphodiesterase
FK178_RS11125	COG2081	HI0933 family
FK178_RS11130	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FK178_RS11150	COG1187	pseudouridine synthase activity
FK178_RS11160	COG0010	Belongs to the arginase family
FK178_RS11195	COG0495	leucyl-tRNA aminoacylation
FK178_RS11200	COG2177	Part of the ABC transporter FtsEX involved in
FK178_RS11210	COG1968	undecaprenyl-diphosphatase activity
FK178_RS11215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FK178_RS11225	COG0519	Catalyzes the synthesis of GMP from XMP
FK178_RS11230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FK178_RS11240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK178_RS11245	COG3852	Histidine kinase
FK178_RS11260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK178_RS11275	COG2205	protein histidine kinase activity
FK178_RS11275	COG0784	Response regulator, receiver
FK178_RS11280	COG2204	response regulator
FK178_RS11290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FK178_RS11315	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FK178_RS11325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FK178_RS11335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FK178_RS11340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FK178_RS11350	COG0612	Peptidase, M16
FK178_RS11385	COG0776	regulation of translation
FK178_RS11390	COG1530	ribonuclease E activity
FK178_RS11425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FK178_RS11430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK178_RS11440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FK178_RS11445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FK178_RS11455	COG0156	8-amino-7-oxononanoate synthase activity
FK178_RS11465	COG1320	monovalent cation:proton antiporter activity
FK178_RS11470	COG2212	antiporter activity
FK178_RS11475	COG1863	multisubunit Na H antiporter MnhE subunit
FK178_RS11480	COG0651	ATP synthesis coupled electron transport
FK178_RS11485	COG1006	Multisubunit Na H antiporter MnhC subunit
FK178_RS11490	COG2111	Na H antiporter
FK178_RS11495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK178_RS11495	COG2111	Na H antiporter
FK178_RS11500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FK178_RS11505	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FK178_RS11510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FK178_RS11520	COG0297	glycogen (starch) synthase activity
FK178_RS11525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FK178_RS11530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FK178_RS11545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FK178_RS11555	COG0667	Aldo Keto reductase
FK178_RS11560	COG1360	Flagellar Motor Protein
FK178_RS11565	COG0708	Exodeoxyribonuclease III
FK178_RS11575	COG0423	glycine-tRNA ligase activity
FK178_RS11585	COG1040	competence protein
FK178_RS11595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK178_RS11605	COG0436	Aminotransferase
FK178_RS11615	COG1053	succinate dehydrogenase
FK178_RS11625	COG0484	heat shock protein binding
FK178_RS11635	COG0006	proline dipeptidase activity
FK178_RS11640	COG1114	Component of the transport system for branched-chain amino acids
FK178_RS11645	COG0596	Alpha beta hydrolase
FK178_RS11655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FK178_RS11660	COG0316	Belongs to the HesB IscA family
FK178_RS11670	COG0719	Fe-S assembly protein
FK178_RS11680	COG0396	ATPase activity
FK178_RS11685	COG0719	Fe-S assembly protein
FK178_RS11700	COG2166	iron-sulfur cluster assembly
FK178_RS11705	COG2151	metal-sulfur cluster biosynthetic enzyme
FK178_RS11720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FK178_RS11755	COG1024	Enoyl-CoA hydratase
FK178_RS11760	COG5000	phosphorelay sensor kinase activity
FK178_RS11765	COG1981	membrane
FK178_RS11775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FK178_RS11790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FK178_RS11795	COG0181	hydroxymethylbilane synthase activity
FK178_RS11805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FK178_RS11815	COG0408	coproporphyrinogen oxidase activity
FK178_RS11830	COG0113	porphobilinogen synthase activity
FK178_RS11845	COG1253	flavin adenine dinucleotide binding
FK178_RS11850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FK178_RS11865	COG1012	belongs to the aldehyde dehydrogenase family
FK178_RS11890	COG2954	triphosphatase activity
FK178_RS11895	COG0702	epimerase
FK178_RS11900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK178_RS11915	COG0571	ribonuclease III activity
FK178_RS11920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK178_RS11925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK178_RS11930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FK178_RS11935	COG0328	RNA-DNA hybrid ribonuclease activity
FK178_RS11945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FK178_RS11955	COG1074	ATP-dependent DNA helicase activity
FK178_RS11960	COG0156	8-amino-7-oxononanoate synthase activity
FK178_RS12005	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FK178_RS12015	COG0720	synthase
FK178_RS12020	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK178_RS12025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FK178_RS12025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FK178_RS12030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FK178_RS12040	COG1435	thymidine kinase activity
FK178_RS12045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FK178_RS12050	COG1970	mechanosensitive ion channel activity
FK178_RS12055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FK178_RS12080	COG1505	serine-type exopeptidase activity
FK178_RS12085	COG3842	ATPase activity
FK178_RS12095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK178_RS12105	COG0439	Biotin carboxylase
FK178_RS12110	COG0511	ligase activity, forming carbon-carbon bonds
FK178_RS12115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FK178_RS12120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FK178_RS12130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FK178_RS12145	COG0006	proline dipeptidase activity
FK178_RS12150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK178_RS12170	COG0346	lactoylglutathione lyase activity
FK178_RS12175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FK178_RS12180	COG4591	ABC-type transport system involved in lipoprotein release permease component
FK178_RS12195	COG1472	Belongs to the glycosyl hydrolase 3 family
FK178_RS12205	COG1940	carbohydrate kinase activity
FK178_RS12205	COG1846	Transcriptional regulator
FK178_RS12210	COG0363	glucosamine-6-phosphate deaminase activity
FK178_RS12215	COG3023	N-Acetylmuramoyl-L-alanine amidase
FK178_RS12220	COG3876	Protein conserved in bacteria
FK178_RS12225	COG0791	NLP P60 protein
FK178_RS12230	COG4948	Mandelate Racemase Muconate Lactonizing
FK178_RS12235	COG4145	pantothenate transmembrane transporter activity
FK178_RS12240	COG1649	PFAM Uncharacterised BCR, COG1649
FK178_RS12255	COG1629	transport
FK178_RS12260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FK178_RS12265	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FK178_RS12285	COG0589	response to stress
FK178_RS12285	COG0475	glutathione-regulated potassium exporter activity
FK178_RS12290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK178_RS12305	COG0594	ribonuclease P activity
FK178_RS12310	COG0793	Belongs to the peptidase S41A family
FK178_RS12315	COG2153	protein acetylation
FK178_RS12325	COG0557	exoribonuclease II activity
FK178_RS12350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK178_RS12380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK178_RS12390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FK178_RS12395	COG0445	tRNA wobble uridine modification
FK178_RS12400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK178_RS12415	COG0470	DNA polymerase III
FK178_RS12420	COG0126	phosphoglycerate kinase activity
FK178_RS12425	COG1388	LysM domain
FK178_RS12425	COG3942	CHAP domain
FK178_RS12435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FK178_RS12440	COG0739	heme binding
FK178_RS12455	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FK178_RS12460	COG1091	dTDP-4-dehydrorhamnose reductase activity
FK178_RS12470	COG1215	transferase activity, transferring glycosyl groups
FK178_RS12480	COG0151	Belongs to the GarS family
FK178_RS12510	COG0859	PFAM glycosyl transferase family 9
FK178_RS12550	COG0356	it plays a direct role in the translocation of protons across the membrane
FK178_RS12555	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FK178_RS12560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FK178_RS12565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FK178_RS12570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FK178_RS12575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FK178_RS12590	COG0756	dUTP diphosphatase activity
FK178_RS12595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FK178_RS12615	COG1607	acyl-coa hydrolase
FK178_RS12625	COG0758	DNA mediated transformation
FK178_RS12625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FK178_RS12655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FK178_RS12660	COG1054	Belongs to the UPF0176 family
FK178_RS12665	COG1774	PSP1 C-terminal conserved region
FK178_RS12675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FK178_RS12680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FK178_RS12690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FK178_RS12710	COG4221	oxidoreductase activity
FK178_RS12720	COG0714	Associated with various cellular activities
FK178_RS12735	COG2304	oxidoreductase activity
FK178_RS12740	COG2304	oxidoreductase activity
FK178_RS12770	COG0288	reversible hydration of carbon dioxide
FK178_RS12785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FK178_RS12795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FK178_RS12800	COG1652	LysM domain
FK178_RS12805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FK178_RS12810	COG0194	GDP metabolic process
FK178_RS12815	COG1561	YicC-like family, N-terminal region
FK178_RS12825	COG0429	hydrolase of the alpha beta-hydrolase fold
FK178_RS12835	COG0697	spore germination
FK178_RS12840	COG1393	Belongs to the ArsC family
FK178_RS12850	COG0626	cystathionine gamma-synthase activity
FK178_RS12865	COG1381	Involved in DNA repair and RecF pathway recombination
FK178_RS12875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FK178_RS12890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FK178_RS12895	COG3279	Response regulator of the LytR AlgR family
FK178_RS12905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FK178_RS12915	COG0189	ligase activity
FK178_RS12925	COG0322	excinuclease ABC activity
FK178_RS12935	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FK178_RS12940	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FK178_RS12960	COG0166	Belongs to the GPI family
FK178_RS12975	COG1418	mRNA catabolic process
FK178_RS13040	COG1999	signal sequence binding
FK178_RS13045	COG0750	zinc metalloprotease
FK178_RS13065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FK178_RS13070	COG1335	isochorismatase
FK178_RS13075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FK178_RS13120	COG1132	(ABC) transporter
FK178_RS13190	COG1472	Belongs to the glycosyl hydrolase 3 family
FK178_RS13205	COG2814	Major facilitator Superfamily
FK178_RS13205	COG0477	Major facilitator Superfamily
FK178_RS13215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FK178_RS13225	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FK178_RS13265	COG2095	MarC family integral membrane protein
FK178_RS13275	COG0492	ferredoxin-NADP+ reductase activity
FK178_RS13355	COG1704	LemA family
FK178_RS13360	COG0501	Belongs to the peptidase M48B family
FK178_RS13370	COG1283	sodium-dependent phosphate transmembrane transporter activity
FK178_RS13400	COG0318	PFAM AMP-dependent synthetase and ligase
FK178_RS13425	COG2223	nitrite transmembrane transporter activity
FK178_RS13445	COG1131	(ABC) transporter
FK178_RS13450	COG1131	(ABC) transporter
FK178_RS13455	COG0842	Transport permease protein
FK178_RS13460	COG1129	ABC transporter
FK178_RS13460	COG0842	Transport permease protein
FK178_RS13480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK178_RS13485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FK178_RS13490	COG0193	aminoacyl-tRNA hydrolase activity
FK178_RS13495	COG0196	riboflavin kinase activity
FK178_RS13505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FK178_RS13525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK178_RS13530	COG2239	Acts as a magnesium transporter
FK178_RS13540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK178_RS13545	COG2827	Endonuclease containing a URI domain
FK178_RS13550	COG4895	conserved protein (DUF2196)
FK178_RS13565	COG0527	aspartate kinase activity
FK178_RS13580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FK178_RS13595	COG1793	dna ligase
FK178_RS13600	COG1201	RNA secondary structure unwinding
FK178_RS13630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FK178_RS13640	COG0792	nuclease activity
FK178_RS13650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK178_RS13650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK178_RS13655	COG2827	Endonuclease containing a URI domain
FK178_RS13660	COG0123	including yeast histone deacetylase and acetoin utilization protein
FK178_RS13665	COG0629	single-stranded DNA binding
FK178_RS13685	COG0589	response to stress
FK178_RS13685	COG0475	glutathione-regulated potassium exporter activity
FK178_RS13695	COG0517	IMP dehydrogenase activity
FK178_RS13710	COG3590	peptidase
FK178_RS13725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK178_RS13730	COG1278	Cold shock
FK178_RS13740	COG0038	chloride channel
FK178_RS13745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FK178_RS13765	COG1538	Outer membrane efflux protein
FK178_RS13790	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK178_RS13805	COG0084	hydrolase, TatD family'
FK178_RS13815	COG0252	asparaginase activity
FK178_RS13825	COG0811	peptide transport
FK178_RS13860	COG0564	pseudouridine synthase activity
FK178_RS13865	COG0017	Asparaginyl-tRNA synthetase
FK178_RS13880	COG0233	cytoplasmic translational termination
FK178_RS13885	COG0528	UMP kinase activity
FK178_RS13890	COG2738	Putative neutral zinc metallopeptidase
FK178_RS13905	COG1522	sequence-specific DNA binding
FK178_RS13920	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FK178_RS13935	COG0463	Glycosyl transferase, family 2
FK178_RS13940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FK178_RS13955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FK178_RS13975	COG1629	transport
FK178_RS13975	COG4206	TonB-dependent receptor
FK178_RS13980	COG0745	RESPONSE REGULATOR receiver
FK178_RS13985	COG5002	protein histidine kinase activity
FK178_RS13990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FK178_RS13995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FK178_RS14005	COG3695	enzyme binding
FK178_RS14010	COG0489	protein tyrosine kinase activity
FK178_RS14020	COG0492	ferredoxin-NADP+ reductase activity
FK178_RS14040	COG1960	acyl-CoA dehydrogenase activity
FK178_RS14050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FK178_RS14055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FK178_RS14060	COG0228	four-way junction DNA binding
FK178_RS14110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK178_RS14125	COG0471	metal ion transport
FK178_RS14150	COG0629	single-stranded DNA binding
FK178_RS14205	COG0463	Glycosyl transferase, family 2
FK178_RS14210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FK178_RS14220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK178_RS14235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FK178_RS14240	COG0052	Belongs to the universal ribosomal protein uS2 family
FK178_RS14245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FK178_RS14250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FK178_RS14265	COG4206	TonB-dependent receptor
FK178_RS14265	COG1629	transport
FK178_RS14275	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FK178_RS14275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FK178_RS14305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FK178_RS14310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FK178_RS14320	COG0295	cytidine deaminase activity
FK178_RS14325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FK178_RS14330	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK178_RS14340	COG1028	Short-chain dehydrogenase reductase Sdr
FK178_RS14350	COG0662	Cupin 2, conserved barrel domain protein
FK178_RS14350	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FK178_RS14360	COG1127	ABC transporter
FK178_RS14365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FK178_RS14375	COG0463	Glycosyl transferase, family 2
FK178_RS14390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FK178_RS14390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FK178_RS14410	COG0339	signal peptide processing
FK178_RS14415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FK178_RS14425	COG0563	adenylate kinase activity
FK178_RS14430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FK178_RS14440	COG2885	chlorophyll binding
FK178_RS14460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK178_RS14465	COG2003	Belongs to the UPF0758 family
FK178_RS14495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FK178_RS14515	COG4771	TonB-dependent receptor
FK178_RS14520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FK178_RS14525	COG0049	tRNA binding
FK178_RS14530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FK178_RS14535	COG0051	transcription antitermination factor activity, RNA binding
FK178_RS14540	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FK178_RS14545	COG0088	Forms part of the polypeptide exit tunnel
FK178_RS14550	COG0089	rRNA binding
FK178_RS14555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FK178_RS14560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FK178_RS14565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FK178_RS14570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FK178_RS14575	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FK178_RS14580	COG0255	Belongs to the universal ribosomal protein uL29 family
FK178_RS14585	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FK178_RS14590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FK178_RS14595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FK178_RS14600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FK178_RS14605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FK178_RS14610	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FK178_RS14615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FK178_RS14620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FK178_RS14625	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FK178_RS14630	COG1841	ribosomal large subunit assembly
FK178_RS14635	COG0200	Binds to the 23S rRNA
FK178_RS14645	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FK178_RS14650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FK178_RS14655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FK178_RS14660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FK178_RS14665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FK178_RS14670	COG0202	RNA polymerase activity
FK178_RS14675	COG0203	ribosomal protein L17
FK178_RS14680	COG0505	Belongs to the CarA family
FK178_RS14700	COG0148	phosphopyruvate hydratase activity
FK178_RS14710	COG4124	Belongs to the glycosyl hydrolase 26 family
FK178_RS14710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FK178_RS14715	COG3250	beta-galactosidase activity
FK178_RS14730	COG1090	epimerase
FK178_RS14745	COG0018	arginyl-trna synthetase
FK178_RS14755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FK178_RS14760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FK178_RS14780	COG1187	pseudouridine synthase activity
FK178_RS14800	COG1619	proteins homologs of microcin C7 resistance protein MccF
FK178_RS14805	COG2027	D-alanyl-D-alanine carboxypeptidase
FK178_RS14810	COG4771	TonB-dependent receptor
FK178_RS14825	COG0602	queuosine metabolic process
FK178_RS14835	COG0367	asparagine synthase
FK178_RS14840	COG0187	DNA topoisomerase II activity
FK178_RS14850	COG0039	L-malate dehydrogenase activity
FK178_RS14855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FK178_RS14865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FK178_RS14870	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FK178_RS14875	COG0215	cysteine-tRNA ligase activity
FK178_RS14880	COG0302	gtp cyclohydrolase
FK178_RS14905	COG0442	prolyl-tRNA aminoacylation
FK178_RS14920	COG0268	Binds directly to 16S ribosomal RNA
FK178_RS14925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FK178_RS14935	COG2001	Belongs to the MraZ family
FK178_RS14940	COG0275	rRNA processing
FK178_RS14955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FK178_RS14960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FK178_RS14965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FK178_RS14975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FK178_RS14980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK178_RS14995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FK178_RS15000	COG1610	YqeY-like protein
FK178_RS15010	COG4974	Belongs to the 'phage' integrase family
FK178_RS15050	COG4585	Histidine kinase
FK178_RS15070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FK178_RS15120	COG1404	Belongs to the peptidase S8 family
FK178_RS15135	COG4585	Histidine kinase
FK178_RS15150	COG2354	Protein conserved in bacteria
FK178_RS15180	COG3275	phosphorelay sensor kinase activity
FK178_RS15195	COG1228	amidohydrolase
FK178_RS15200	COG0784	Response regulator, receiver
FK178_RS15200	COG2205	protein histidine kinase activity
FK178_RS15205	COG3279	Response regulator of the LytR AlgR family
FK178_RS15210	COG3275	phosphorelay sensor kinase activity
FK178_RS15220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK178_RS15235	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FK178_RS15240	COG0732	type I restriction modification DNA specificity domain
FK178_RS15285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FK178_RS15305	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FK178_RS15305	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FK178_RS15315	COG4771	TonB-dependent receptor
FK178_RS15330	COG2986	histidine ammonia-lyase
FK178_RS15335	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FK178_RS15340	COG2610	gluconate transmembrane transporter activity
FK178_RS15345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FK178_RS15365	COG1522	sequence-specific DNA binding
FK178_RS15380	COG4585	Histidine kinase
FK178_RS15575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance