locus-tag	class	description
LZ575_RS00020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LZ575_RS00025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LZ575_RS00045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LZ575_RS00055	COG0534	Mate efflux family protein
LZ575_RS00065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LZ575_RS00125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LZ575_RS00130	COG2996	Protein conserved in bacteria
LZ575_RS00230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ575_RS00250	COG0668	transmembrane transport
LZ575_RS00255	COG0783	Belongs to the Dps family
LZ575_RS00275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ575_RS00285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LZ575_RS00295	COG1218	3'(2'),5'-bisphosphate nucleotidase
LZ575_RS00305	COG0529	Catalyzes the synthesis of activated sulfate
LZ575_RS00310	COG0175	sulfate reduction
LZ575_RS00360	COG0463	Glycosyl transferase, family 2
LZ575_RS00410	COG1083	cytidylyl-transferase
LZ575_RS00415	COG1083	cytidylyl-transferase
LZ575_RS00425	COG1132	(ABC) transporter
LZ575_RS00435	COG0463	Glycosyl transferase, family 2
LZ575_RS00435	COG1216	Glycosyl transferase, family 2
LZ575_RS00440	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS00460	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS00470	COG0463	Glycosyl transferase, family 2
LZ575_RS00485	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS00510	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS00530	COG0367	asparagine synthase
LZ575_RS00535	COG0463	Glycosyl transferase, family 2
LZ575_RS00535	COG1216	Glycosyl transferase, family 2
LZ575_RS00545	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS00545	COG0297	glycogen (starch) synthase activity
LZ575_RS00575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LZ575_RS00610	COG2201	protein-glutamate methylesterase activity
LZ575_RS00650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LZ575_RS00660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LZ575_RS00705	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LZ575_RS00755	COG0339	signal peptide processing
LZ575_RS00770	COG4251	negative regulation of phosphorylation
LZ575_RS00795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LZ575_RS00850	COG2819	hydrolase of the alpha beta superfamily
LZ575_RS00875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LZ575_RS00885	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LZ575_RS00885	COG3264	Mechanosensitive ion channel
LZ575_RS00890	COG1960	acyl-CoA dehydrogenase activity
LZ575_RS00900	COG0183	Belongs to the thiolase family
LZ575_RS00920	COG1482	cell wall glycoprotein biosynthetic process
LZ575_RS00945	COG1876	peptidase activity
LZ575_RS00955	COG0640	Transcriptional regulator
LZ575_RS00995	COG2311	Membrane
LZ575_RS01000	COG2311	Membrane
LZ575_RS01010	COG2890	protein-(glutamine-N5) methyltransferase activity
LZ575_RS01020	COG2205	protein histidine kinase activity
LZ575_RS01020	COG0784	Response regulator, receiver
LZ575_RS01040	COG3621	Patatin-like phospholipase
LZ575_RS01045	COG0545	Peptidyl-prolyl cis-trans isomerase
LZ575_RS01050	COG3920	Histidine kinase
LZ575_RS01085	COG3177	Filamentation induced by cAMP protein fic
LZ575_RS01090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS01095	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS01100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS01135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LZ575_RS01300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LZ575_RS01445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZ575_RS01470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LZ575_RS01475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LZ575_RS01485	COG1295	ribonuclease BN
LZ575_RS01510	COG0360	Binds together with S18 to 16S ribosomal RNA
LZ575_RS01515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LZ575_RS01520	COG0359	binds to the 23S rRNA
LZ575_RS01635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LZ575_RS01665	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LZ575_RS01680	COG4783	chaperone-mediated protein folding
LZ575_RS01705	COG1595	DNA-templated transcription, initiation
LZ575_RS01715	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LZ575_RS01725	COG0539	negative regulation of cytoplasmic translation
LZ575_RS01735	COG0540	Belongs to the ATCase OTCase family
LZ575_RS01750	COG0259	pyridoxamine-phosphate oxidase activity
LZ575_RS01765	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LZ575_RS01790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LZ575_RS01810	COG0742	ribosomal rna small subunit methyltransferase
LZ575_RS01830	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LZ575_RS01835	COG0415	Belongs to the DNA photolyase family
LZ575_RS01840	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS01880	COG0424	maF-like protein
LZ575_RS01905	COG1333	cytochrome c biogenesis protein
LZ575_RS01905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LZ575_RS01950	COG1393	Belongs to the ArsC family
LZ575_RS01970	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LZ575_RS01985	COG0156	8-amino-7-oxononanoate synthase activity
LZ575_RS02030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LZ575_RS02035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LZ575_RS02060	COG0802	atpase or kinase
LZ575_RS02065	COG2204	response regulator
LZ575_RS02070	COG1078	dGTPase activity
LZ575_RS02075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZ575_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS02135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LZ575_RS02140	COG0131	Imidazoleglycerol-phosphate dehydratase
LZ575_RS02155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LZ575_RS02160	COG0107	imidazoleglycerol-phosphate synthase activity
LZ575_RS02165	COG0140	phosphoribosyl-ATP diphosphatase activity
LZ575_RS02165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LZ575_RS02205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LZ575_RS02230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LZ575_RS02270	COG1047	Peptidyl-prolyl cis-trans
LZ575_RS02285	COG0671	phosphoesterase, PA-phosphatase related
LZ575_RS02320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZ575_RS02350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LZ575_RS02355	COG2169	Transcriptional regulator
LZ575_RS02415	COG4628	conserved protein (DUF2132)
LZ575_RS02440	COG0860	N-Acetylmuramoyl-L-alanine amidase
LZ575_RS02445	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LZ575_RS02470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LZ575_RS02490	COG1024	Enoyl-CoA hydratase
LZ575_RS02490	COG1250	3-hydroxyacyl-CoA dehydrogenase
LZ575_RS02535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZ575_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS02625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LZ575_RS02640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LZ575_RS02645	COG1193	negative regulation of DNA recombination
LZ575_RS02650	COG3011	Protein conserved in bacteria
LZ575_RS02655	COG1301	dicarboxylic acid transport
LZ575_RS02670	COG0247	lactate metabolic process
LZ575_RS02670	COG0277	FAD linked oxidase domain protein
LZ575_RS02680	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS02685	COG1472	Belongs to the glycosyl hydrolase 3 family
LZ575_RS02700	COG0247	lactate metabolic process
LZ575_RS02700	COG2181	nitrate reductase activity
LZ575_RS02710	COG0860	N-Acetylmuramoyl-L-alanine amidase
LZ575_RS02720	COG0251	oxidation-reduction process
LZ575_RS02725	COG1803	Methylglyoxal synthase
LZ575_RS02765	COG0628	permease
LZ575_RS02795	COG1215	transferase activity, transferring glycosyl groups
LZ575_RS02835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZ575_RS02855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LZ575_RS02950	COG2972	Histidine kinase
LZ575_RS02955	COG3279	Response regulator of the LytR AlgR family
LZ575_RS02965	COG0837	glucose binding
LZ575_RS02970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LZ575_RS03130	COG4974	Belongs to the 'phage' integrase family
LZ575_RS03260	COG0531	amino acid
LZ575_RS03265	COG2264	protein methyltransferase activity
LZ575_RS03290	COG0189	ligase activity
LZ575_RS03300	COG0189	ligase activity
LZ575_RS03320	COG0366	Alpha amylase catalytic
LZ575_RS03325	COG0366	Alpha amylase catalytic
LZ575_RS03330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ575_RS03420	COG1215	transferase activity, transferring glycosyl groups
LZ575_RS03465	COG2706	6-phosphogluconolactonase activity
LZ575_RS03475	COG0598	Magnesium transport protein CorA
LZ575_RS03485	COG2852	Protein conserved in bacteria
LZ575_RS03495	COG1061	Type III restriction enzyme res subunit
LZ575_RS03525	COG1289	transmembrane transporter activity
LZ575_RS03575	COG0401	homolog of Blt101
LZ575_RS03580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LZ575_RS03585	COG2814	Major facilitator Superfamily
LZ575_RS03590	COG0668	transmembrane transport
LZ575_RS03600	COG0668	transmembrane transport
LZ575_RS03655	COG0791	NLP P60 protein
LZ575_RS03680	COG2986	histidine ammonia-lyase
LZ575_RS03690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LZ575_RS03700	COG2154	pterin-4-alpha-carbinolamine dehydratase
LZ575_RS03705	COG0217	transcriptional regulatory protein
LZ575_RS03715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LZ575_RS03730	COG1295	ribonuclease BN
LZ575_RS03785	COG0012	GTP binding
LZ575_RS03795	COG0280	phosphate acetyltransferase
LZ575_RS03795	COG0857	belongs to the CobB CobQ family
LZ575_RS03800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LZ575_RS03845	COG1640	4-alpha-glucanotransferase
LZ575_RS03885	COG0366	Alpha amylase catalytic
LZ575_RS03890	COG0366	Alpha amylase catalytic
LZ575_RS03895	COG0366	Alpha amylase catalytic
LZ575_RS03940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LZ575_RS03980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LZ575_RS04005	COG2205	protein histidine kinase activity
LZ575_RS04005	COG2202	Pas domain
LZ575_RS04020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LZ575_RS04070	COG0514	ATP-dependent DNA helicase (RecQ)
LZ575_RS04075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LZ575_RS04085	COG1678	Uncharacterized ACR, COG1678
LZ575_RS04090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LZ575_RS04105	COG0587	DNA-directed DNA polymerase activity
LZ575_RS04170	COG0531	amino acid
LZ575_RS04195	COG2814	Major facilitator Superfamily
LZ575_RS04200	COG2217	Heavy metal translocating P-type atpase
LZ575_RS04240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LZ575_RS04245	COG3174	membrane
LZ575_RS04260	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
LZ575_RS04270	COG0205	6-phosphofructokinase activity
LZ575_RS04275	COG1830	Aldolase
LZ575_RS04305	COG2217	Heavy metal translocating P-type atpase
LZ575_RS04380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LZ575_RS04385	COG2217	Heavy metal translocating P-type atpase
LZ575_RS04470	COG2217	Heavy metal translocating P-type atpase
LZ575_RS04500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LZ575_RS04510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LZ575_RS04575	COG0860	N-Acetylmuramoyl-L-alanine amidase
LZ575_RS04575	COG2247	cell wall binding repeat
LZ575_RS04635	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS04640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS04650	COG1196	nuclear chromosome segregation
LZ575_RS04670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LZ575_RS04715	COG0629	single-stranded DNA binding
LZ575_RS04735	COG1741	Belongs to the pirin family
LZ575_RS04740	COG1741	Belongs to the pirin family
LZ575_RS04765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ575_RS04800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LZ575_RS04855	COG4206	TonB-dependent receptor
LZ575_RS04880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LZ575_RS04900	COG1607	acyl-coa hydrolase
LZ575_RS04910	COG2363	Small membrane protein
LZ575_RS04925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LZ575_RS04970	COG0254	rRNA binding
LZ575_RS04985	COG0463	Glycosyl transferase, family 2
LZ575_RS04995	COG1132	(ABC) transporter
LZ575_RS05000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LZ575_RS05015	COG1595	DNA-templated transcription, initiation
LZ575_RS05075	COG2183	response to ionizing radiation
LZ575_RS05105	COG0702	epimerase
LZ575_RS05155	COG0673	inositol 2-dehydrogenase activity
LZ575_RS05185	COG3279	Response regulator of the LytR AlgR family
LZ575_RS05315	COG0492	ferredoxin-NADP+ reductase activity
LZ575_RS05330	COG0562	UDP-galactopyranose mutase
LZ575_RS05350	COG0439	Biotin carboxylase
LZ575_RS05380	COG1271	oxidase subunit
LZ575_RS05385	COG1272	protein, Hemolysin III
LZ575_RS05395	COG0419	ATPase involved in DNA repair
LZ575_RS05410	COG2133	pyrroloquinoline quinone binding
LZ575_RS05440	COG4206	TonB-dependent receptor
LZ575_RS05440	COG1629	transport
LZ575_RS05445	COG3275	phosphorelay sensor kinase activity
LZ575_RS05450	COG3279	Response regulator of the LytR AlgR family
LZ575_RS05480	COG1064	alcohol dehydrogenase
LZ575_RS05495	COG1063	alcohol dehydrogenase
LZ575_RS05565	COG0351	phosphomethylpyrimidine kinase
LZ575_RS05565	COG0352	thiamine-phosphate diphosphorylase activity
LZ575_RS05580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LZ575_RS05585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LZ575_RS05640	COG0210	DNA helicase
LZ575_RS05660	COG4106	trans-aconitate 2-methyltransferase activity
LZ575_RS05690	COG4974	Belongs to the 'phage' integrase family
LZ575_RS05700	COG1484	DNA-dependent DNA replication
LZ575_RS05720	COG4974	Belongs to the 'phage' integrase family
LZ575_RS05735	COG1725	Transcriptional regulator
LZ575_RS05750	COG2133	pyrroloquinoline quinone binding
LZ575_RS05755	COG2010	Cytochrome c
LZ575_RS05760	COG0572	uridine kinase
LZ575_RS05770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LZ575_RS05800	COG1192	Involved in chromosome partitioning
LZ575_RS05805	COG1475	DNA binding
LZ575_RS05865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LZ575_RS05880	COG0105	UTP biosynthetic process
LZ575_RS05895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LZ575_RS05900	COG2195	Cleaves the N-terminal amino acid of tripeptides
LZ575_RS05920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LZ575_RS05925	COG0501	Belongs to the peptidase M48B family
LZ575_RS05930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LZ575_RS05940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LZ575_RS06055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ575_RS06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ575_RS06065	COG1012	belongs to the aldehyde dehydrogenase family
LZ575_RS06070	COG1012	belongs to the aldehyde dehydrogenase family
LZ575_RS06105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ575_RS06125	COG2354	Protein conserved in bacteria
LZ575_RS06145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ575_RS06155	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LZ575_RS06165	COG1215	transferase activity, transferring glycosyl groups
LZ575_RS06170	COG2197	response regulator
LZ575_RS06195	COG1570	exodeoxyribonuclease VII activity
LZ575_RS06205	COG0058	SHG alpha-glucan phosphorylase activity
LZ575_RS06210	COG0058	SHG alpha-glucan phosphorylase activity
LZ575_RS06230	COG4181	ATPase activity
LZ575_RS06240	COG4191	Histidine kinase
LZ575_RS06255	COG4191	Histidine kinase
LZ575_RS06265	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
LZ575_RS06270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LZ575_RS06325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LZ575_RS06345	COG0242	peptide deformylase activity
LZ575_RS06350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LZ575_RS06355	COG2171	N-acyltransferase activity
LZ575_RS06380	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS06385	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS06385	COG4641	Protein conserved in bacteria
LZ575_RS06435	COG1131	(ABC) transporter
LZ575_RS06455	COG0071	Belongs to the small heat shock protein (HSP20) family
LZ575_RS06480	COG0037	tRNA processing
LZ575_RS06485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LZ575_RS06515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LZ575_RS06525	COG1522	sequence-specific DNA binding
LZ575_RS06540	COG0450	alkyl hydroperoxide reductase
LZ575_RS06585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LZ575_RS06585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LZ575_RS06590	COG0778	Nitroreductase
LZ575_RS06605	COG0561	phosphatase activity
LZ575_RS06635	COG1278	Cold shock
LZ575_RS06650	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LZ575_RS06665	COG0706	membrane insertase activity
LZ575_RS06670	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LZ575_RS06680	COG0482	sulfurtransferase activity
LZ575_RS06715	COG3942	CHAP domain
LZ575_RS06715	COG1388	LysM domain
LZ575_RS06730	COG0259	pyridoxamine-phosphate oxidase activity
LZ575_RS06740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LZ575_RS06745	COG0626	cystathionine gamma-synthase activity
LZ575_RS06750	COG1228	amidohydrolase
LZ575_RS06755	COG0010	Belongs to the arginase family
LZ575_RS06775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LZ575_RS06805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LZ575_RS06905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LZ575_RS06910	COG1575	Belongs to the MenA family. Type 1 subfamily
LZ575_RS06940	COG0009	L-threonylcarbamoyladenylate synthase
LZ575_RS07030	COG0488	(ABC) transporter
LZ575_RS07040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LZ575_RS07060	COG0824	Thioesterase
LZ575_RS07075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LZ575_RS07125	COG0789	Transcriptional regulator
LZ575_RS07130	COG1704	LemA family
LZ575_RS07155	COG1160	GTP binding
LZ575_RS07160	COG0655	NAD(P)H dehydrogenase (quinone) activity
LZ575_RS07165	COG0673	inositol 2-dehydrogenase activity
LZ575_RS07230	COG0604	alcohol dehydrogenase
LZ575_RS07260	COG3279	Response regulator of the LytR AlgR family
LZ575_RS07265	COG3279	Response regulator of the LytR AlgR family
LZ575_RS07360	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
LZ575_RS07390	COG0534	Mate efflux family protein
LZ575_RS07465	COG3279	Response regulator of the LytR AlgR family
LZ575_RS07470	COG3275	phosphorelay sensor kinase activity
LZ575_RS07475	COG1131	(ABC) transporter
LZ575_RS07515	COG4771	TonB-dependent receptor
LZ575_RS07520	COG1629	transport
LZ575_RS07520	COG4206	TonB-dependent receptor
LZ575_RS07535	COG0668	transmembrane transport
LZ575_RS07540	COG1902	pentaerythritol trinitrate reductase activity
LZ575_RS07545	COG2234	aminopeptidase activity
LZ575_RS07550	COG0076	glutamate decarboxylase activity
LZ575_RS07555	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LZ575_RS07580	COG0612	Peptidase, M16
LZ575_RS07660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LZ575_RS07665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LZ575_RS07685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LZ575_RS07690	COG0508	dehydrogenase complex catalyzes the overall conversion of
LZ575_RS07695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LZ575_RS07700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZ575_RS07715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LZ575_RS07745	COG2198	Histidine kinase
LZ575_RS07745	COG2205	protein histidine kinase activity
LZ575_RS07745	COG0784	Response regulator, receiver
LZ575_RS07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ575_RS07750	COG3437	response regulator, receiver
LZ575_RS07750	COG2205	protein histidine kinase activity
LZ575_RS07750	COG3850	Histidine kinase
LZ575_RS07750	COG4999	Histidine kinase
LZ575_RS07800	COG0561	phosphatase activity
LZ575_RS07815	COG0579	oxidoreductase
LZ575_RS07835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LZ575_RS07850	COG2153	protein acetylation
LZ575_RS07875	COG0222	ribosome binding
LZ575_RS07880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LZ575_RS07910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LZ575_RS07940	COG4974	Belongs to the 'phage' integrase family
LZ575_RS07945	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LZ575_RS07950	COG1960	acyl-CoA dehydrogenase activity
LZ575_RS08045	COG2884	Cell division ATP-binding protein ftsE
LZ575_RS08055	COG1217	gtp-binding protein TYPA
LZ575_RS08065	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LZ575_RS08070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ575_RS08095	COG1785	Belongs to the alkaline phosphatase family
LZ575_RS08100	COG1785	Belongs to the alkaline phosphatase family
LZ575_RS08110	COG0733	neurotransmitter:sodium symporter activity
LZ575_RS08120	COG4999	Histidine kinase
LZ575_RS08120	COG2205	protein histidine kinase activity
LZ575_RS08120	COG3850	Histidine kinase
LZ575_RS08120	COG3437	response regulator, receiver
LZ575_RS08125	COG0745	RESPONSE REGULATOR receiver
LZ575_RS08145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LZ575_RS08160	COG1522	sequence-specific DNA binding
LZ575_RS08210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LZ575_RS08235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LZ575_RS08280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZ575_RS08300	COG0450	alkyl hydroperoxide reductase
LZ575_RS08315	COG0517	IMP dehydrogenase activity
LZ575_RS08315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LZ575_RS08320	COG0805	protein transport
LZ575_RS08325	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LZ575_RS08335	COG1137	ATPase activity
LZ575_RS08360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LZ575_RS08495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LZ575_RS08500	COG0463	Glycosyl transferase, family 2
LZ575_RS08505	COG1215	transferase activity, transferring glycosyl groups
LZ575_RS08530	COG0297	glycogen (starch) synthase activity
LZ575_RS08645	COG2852	Protein conserved in bacteria
LZ575_RS08650	COG1083	cytidylyl-transferase
LZ575_RS08655	COG0367	asparagine synthase
LZ575_RS08665	COG1752	Esterase of the alpha-beta hydrolase superfamily
LZ575_RS08675	COG0489	protein tyrosine kinase activity
LZ575_RS08735	COG1082	Xylose isomerase domain protein TIM barrel
LZ575_RS08755	COG2133	pyrroloquinoline quinone binding
LZ575_RS08775	COG1136	(ABC) transporter
LZ575_RS08795	COG0653	protein targeting
LZ575_RS08800	COG0653	protein targeting
LZ575_RS08860	COG1764	response to oxidative stress
LZ575_RS08870	COG0463	Glycosyl transferase, family 2
LZ575_RS08885	COG0671	phosphoesterase, PA-phosphatase related
LZ575_RS08895	COG0534	Mate efflux family protein
LZ575_RS08930	COG4152	abc transporter atp-binding protein
LZ575_RS08940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LZ575_RS08965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LZ575_RS08995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LZ575_RS09020	COG0513	Belongs to the DEAD box helicase family
LZ575_RS09025	COG2226	methyltransferase
LZ575_RS09030	COG2095	MarC family integral membrane protein
LZ575_RS09060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LZ575_RS09065	COG0284	orotidine-5'-phosphate decarboxylase activity
LZ575_RS09070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LZ575_RS09075	COG1120	ATPase activity
LZ575_RS09120	COG0655	NAD(P)H dehydrogenase (quinone) activity
LZ575_RS09145	COG0673	inositol 2-dehydrogenase activity
LZ575_RS09150	COG0673	inositol 2-dehydrogenase activity
LZ575_RS09160	COG0071	Belongs to the small heat shock protein (HSP20) family
LZ575_RS09200	COG5002	protein histidine kinase activity
LZ575_RS09200	COG3850	Histidine kinase
LZ575_RS09210	COG0745	RESPONSE REGULATOR receiver
LZ575_RS09230	COG2217	Heavy metal translocating P-type atpase
LZ575_RS09240	COG3546	catalase activity
LZ575_RS09245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZ575_RS09255	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
LZ575_RS09280	COG2186	Transcriptional regulator
LZ575_RS09310	COG0702	epimerase
LZ575_RS09315	COG4771	TonB-dependent receptor
LZ575_RS09325	COG3119	arylsulfatase activity
LZ575_RS09345	COG3250	beta-galactosidase activity
LZ575_RS09350	COG3119	arylsulfatase activity
LZ575_RS09400	COG4680	protein conserved in bacteria
LZ575_RS09470	COG0702	epimerase
LZ575_RS09475	COG1629	transport
LZ575_RS09485	COG1629	transport
LZ575_RS09490	COG4771	TonB-dependent receptor
LZ575_RS09500	COG3328	transposase activity
LZ575_RS09505	COG3386	PFAM SMP-30 Gluconolaconase
LZ575_RS09515	COG3250	beta-galactosidase activity
LZ575_RS09525	COG4948	Mandelate Racemase Muconate Lactonizing
LZ575_RS09530	COG4948	Mandelate Racemase Muconate Lactonizing
LZ575_RS09545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LZ575_RS09600	COG0457	Tetratricopeptide repeat
LZ575_RS09635	COG4206	TonB-dependent receptor
LZ575_RS09635	COG1629	transport
LZ575_RS09650	COG1595	DNA-templated transcription, initiation
LZ575_RS09670	COG0629	single-stranded DNA binding
LZ575_RS09715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LZ575_RS09725	COG4584	PFAM Integrase catalytic
LZ575_RS09890	COG2274	protein secretion by the type I secretion system
LZ575_RS09995	COG2197	response regulator
LZ575_RS10145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LZ575_RS10200	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LZ575_RS10215	COG1605	Chorismate mutase
LZ575_RS10215	COG0077	Prephenate dehydratase
LZ575_RS10260	COG1765	OsmC-like protein
LZ575_RS10305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LZ575_RS10365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LZ575_RS10500	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS10575	COG1428	Deoxynucleoside kinase
LZ575_RS10585	COG1793	dna ligase
LZ575_RS10585	COG3285	dna ligase
LZ575_RS10605	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS10615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LZ575_RS10630	COG2086	electron transfer activity
LZ575_RS10635	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LZ575_RS10675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LZ575_RS10680	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LZ575_RS10700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LZ575_RS10750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LZ575_RS10770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LZ575_RS10775	COG0492	ferredoxin-NADP+ reductase activity
LZ575_RS10785	COG2814	Major facilitator Superfamily
LZ575_RS10795	COG1011	Hydrolase
LZ575_RS10855	COG1846	Transcriptional regulator
LZ575_RS10855	COG1940	carbohydrate kinase activity
LZ575_RS10870	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LZ575_RS10880	COG4771	TonB-dependent receptor
LZ575_RS10885	COG4771	TonB-dependent receptor
LZ575_RS10905	COG4191	Histidine kinase
LZ575_RS10920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZ575_RS10950	COG0746	molybdenum cofactor guanylyltransferase activity
LZ575_RS10965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LZ575_RS10985	COG0243	molybdopterin cofactor binding
LZ575_RS11005	COG2223	nitrite transmembrane transporter activity
LZ575_RS11090	COG1309	transcriptional regulator
LZ575_RS11115	COG2223	nitrite transmembrane transporter activity
LZ575_RS11200	COG1054	Belongs to the UPF0176 family
LZ575_RS11225	COG1045	serine acetyltransferase
LZ575_RS11270	COG0737	Belongs to the 5'-nucleotidase family
LZ575_RS11280	COG3258	Cytochrome c
LZ575_RS11335	COG0629	single-stranded DNA binding
LZ575_RS11340	COG2003	Belongs to the UPF0758 family
LZ575_RS11380	COG4974	Belongs to the 'phage' integrase family
LZ575_RS11430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LZ575_RS11435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LZ575_RS11465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LZ575_RS11470	COG0268	Binds directly to 16S ribosomal RNA
LZ575_RS11515	COG0302	gtp cyclohydrolase
LZ575_RS11525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LZ575_RS11560	COG0187	DNA topoisomerase II activity
LZ575_RS11575	COG2027	D-alanyl-D-alanine carboxypeptidase
LZ575_RS11600	COG1619	proteins homologs of microcin C7 resistance protein MccF
LZ575_RS11625	COG1187	pseudouridine synthase activity
LZ575_RS11645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LZ575_RS11735	COG0148	phosphopyruvate hydratase activity
LZ575_RS11745	COG0203	ribosomal protein L17
LZ575_RS11750	COG0202	RNA polymerase activity
LZ575_RS11755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LZ575_RS11760	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LZ575_RS11765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LZ575_RS11770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LZ575_RS11775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LZ575_RS11785	COG0200	Binds to the 23S rRNA
LZ575_RS11790	COG1841	ribosomal large subunit assembly
LZ575_RS11805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LZ575_RS11820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LZ575_RS11830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LZ575_RS11835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LZ575_RS11840	COG0255	Belongs to the universal ribosomal protein uL29 family
LZ575_RS11845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LZ575_RS11850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LZ575_RS11855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LZ575_RS11860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LZ575_RS11870	COG0089	rRNA binding
LZ575_RS11875	COG0088	Forms part of the polypeptide exit tunnel
LZ575_RS11885	COG0051	transcription antitermination factor activity, RNA binding
LZ575_RS11895	COG0049	tRNA binding
LZ575_RS11900	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LZ575_RS11915	COG4771	TonB-dependent receptor
LZ575_RS11935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LZ575_RS11945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LZ575_RS11975	COG2003	Belongs to the UPF0758 family
LZ575_RS11995	COG2885	chlorophyll binding
LZ575_RS12005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LZ575_RS12010	COG0563	adenylate kinase activity
LZ575_RS12020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LZ575_RS12075	COG1127	ABC transporter
LZ575_RS12085	COG0662	Cupin 2, conserved barrel domain protein
LZ575_RS12085	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LZ575_RS12110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LZ575_RS12125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LZ575_RS12145	COG0285	dihydrofolate synthase activity
LZ575_RS12155	COG0848	biopolymer transport protein
LZ575_RS12310	COG4771	TonB-dependent receptor
LZ575_RS12315	COG4771	TonB-dependent receptor
LZ575_RS12320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LZ575_RS12340	COG0321	lipoyl(octanoyl) transferase activity
LZ575_RS12345	COG0401	homolog of Blt101
LZ575_RS12455	COG0138	bifunctional purine biosynthesis protein purh
LZ575_RS12490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LZ575_RS12500	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZ575_RS12505	COG0791	NLP P60 protein
LZ575_RS12525	COG0823	Involved in the tonB-independent uptake of proteins
LZ575_RS12525	COG1506	peptidase
LZ575_RS12540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LZ575_RS12620	COG1595	DNA-templated transcription, initiation
LZ575_RS12625	COG2353	YceI-like domain
LZ575_RS12675	COG0489	protein tyrosine kinase activity
LZ575_RS12675	COG3206	protein involved in exopolysaccharide biosynthesis
LZ575_RS12720	COG0463	Glycosyl transferase, family 2
LZ575_RS12745	COG0463	Glycosyl transferase, family 2
LZ575_RS12745	COG1216	Glycosyl transferase, family 2
LZ575_RS12760	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LZ575_RS12805	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LZ575_RS12810	COG4771	TonB-dependent receptor
LZ575_RS12815	COG4771	TonB-dependent receptor
LZ575_RS12820	COG4771	TonB-dependent receptor
LZ575_RS12845	COG2226	methyltransferase
LZ575_RS12885	COG1215	transferase activity, transferring glycosyl groups
LZ575_RS12920	COG2824	Alkylphosphonate utilization operon protein PhnA
LZ575_RS12925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LZ575_RS12940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LZ575_RS12945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LZ575_RS12955	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS12970	COG3665	Urea carboxylase-associated protein
LZ575_RS12980	COG2808	Putative FMN-binding domain
LZ575_RS12995	COG4095	Psort location CytoplasmicMembrane, score
LZ575_RS13000	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS13005	COG0584	glycerophosphoryl diester phosphodiesterase
LZ575_RS13010	COG2081	HI0933 family
LZ575_RS13035	COG1187	pseudouridine synthase activity
LZ575_RS13045	COG0010	Belongs to the arginase family
LZ575_RS13055	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LZ575_RS13055	COG3952	Lipid A Biosynthesis
LZ575_RS13065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LZ575_RS13070	COG2315	Protein conserved in bacteria
LZ575_RS13090	COG0495	leucyl-tRNA aminoacylation
LZ575_RS13095	COG0495	leucyl-tRNA aminoacylation
LZ575_RS13100	COG0495	leucyl-tRNA aminoacylation
LZ575_RS13105	COG0495	leucyl-tRNA aminoacylation
LZ575_RS13110	COG2177	Part of the ABC transporter FtsEX involved in
LZ575_RS13125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LZ575_RS13135	COG0519	Catalyzes the synthesis of GMP from XMP
LZ575_RS13150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LZ575_RS13170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LZ575_RS13185	COG5002	protein histidine kinase activity
LZ575_RS13185	COG2205	protein histidine kinase activity
LZ575_RS13185	COG0784	Response regulator, receiver
LZ575_RS13190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LZ575_RS13190	COG2205	protein histidine kinase activity
LZ575_RS13190	COG0784	Response regulator, receiver
LZ575_RS13190	COG2198	Histidine kinase
LZ575_RS13205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LZ575_RS13250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LZ575_RS13265	COG0612	Peptidase, M16
LZ575_RS13290	COG0629	single-stranded DNA binding
LZ575_RS13300	COG0776	regulation of translation
LZ575_RS13305	COG1530	ribonuclease E activity
LZ575_RS13315	COG2137	regulation of response to DNA damage stimulus
LZ575_RS13340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LZ575_RS13360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LZ575_RS13380	COG1320	monovalent cation:proton antiporter activity
LZ575_RS13390	COG1863	multisubunit Na H antiporter MnhE subunit
LZ575_RS13400	COG1006	Multisubunit Na H antiporter MnhC subunit
LZ575_RS13420	COG3655	Transcriptional regulator
LZ575_RS13455	COG0297	glycogen (starch) synthase activity
LZ575_RS13460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LZ575_RS13465	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LZ575_RS13490	COG0739	heme binding
LZ575_RS13495	COG0667	Aldo Keto reductase
LZ575_RS13500	COG1360	Flagellar Motor Protein
LZ575_RS13505	COG0708	Exodeoxyribonuclease III
LZ575_RS13595	COG0006	proline dipeptidase activity
LZ575_RS13620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LZ575_RS13645	COG0396	ATPase activity
LZ575_RS13655	COG0719	Fe-S assembly protein
LZ575_RS13670	COG2166	iron-sulfur cluster assembly
LZ575_RS13675	COG2151	metal-sulfur cluster biosynthetic enzyme
LZ575_RS13690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LZ575_RS13750	COG1981	membrane
LZ575_RS13775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LZ575_RS13805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LZ575_RS13820	COG0408	coproporphyrinogen oxidase activity
LZ575_RS13825	COG0113	porphobilinogen synthase activity
LZ575_RS13830	COG1253	flavin adenine dinucleotide binding
LZ575_RS13895	COG1538	Outer membrane efflux protein
LZ575_RS13915	COG2954	triphosphatase activity
LZ575_RS13940	COG0571	ribonuclease III activity
LZ575_RS13945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LZ575_RS13950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LZ575_RS13960	COG0328	RNA-DNA hybrid ribonuclease activity
LZ575_RS13980	COG1074	ATP-dependent DNA helicase activity
LZ575_RS13995	COG0156	8-amino-7-oxononanoate synthase activity
LZ575_RS14000	COG2885	chlorophyll binding
LZ575_RS14040	COG0534	Mate efflux family protein
LZ575_RS14085	COG2161	toxin-antitoxin pair type II binding
LZ575_RS14120	COG1970	mechanosensitive ion channel activity
LZ575_RS14125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LZ575_RS14145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LZ575_RS14150	COG0579	oxidoreductase
LZ575_RS14160	COG0511	ligase activity, forming carbon-carbon bonds
LZ575_RS14170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LZ575_RS14180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LZ575_RS14245	COG1842	Phage shock protein A
LZ575_RS14280	COG1785	Belongs to the alkaline phosphatase family
LZ575_RS14320	COG4771	TonB-dependent receptor
LZ575_RS14330	COG1629	transport
LZ575_RS14335	COG4771	TonB-dependent receptor
LZ575_RS14340	COG1609	Transcriptional regulator
LZ575_RS14345	COG1609	Transcriptional regulator
LZ575_RS14355	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LZ575_RS14370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LZ575_RS14370	COG2010	Cytochrome c
LZ575_RS14375	COG2080	2 iron, 2 sulfur cluster binding
LZ575_RS14405	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ575_RS14430	COG4771	TonB-dependent receptor
LZ575_RS14435	COG4771	TonB-dependent receptor
LZ575_RS14475	COG0732	type I restriction modification DNA specificity domain
LZ575_RS14485	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS14490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS14555	COG0346	lactoylglutathione lyase activity
LZ575_RS14560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LZ575_RS14565	COG4591	ABC-type transport system involved in lipoprotein release permease component
LZ575_RS14595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LZ575_RS14605	COG1472	Belongs to the glycosyl hydrolase 3 family
LZ575_RS14620	COG4948	Mandelate Racemase Muconate Lactonizing
LZ575_RS14625	COG1649	PFAM Uncharacterised BCR, COG1649
LZ575_RS14630	COG1929	Belongs to the glycerate kinase type-1 family
LZ575_RS14640	COG2610	gluconate transmembrane transporter activity
LZ575_RS14645	COG2610	gluconate transmembrane transporter activity
LZ575_RS14650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LZ575_RS14660	COG1940	carbohydrate kinase activity
LZ575_RS14690	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LZ575_RS14705	COG1940	carbohydrate kinase activity
LZ575_RS14710	COG0673	inositol 2-dehydrogenase activity
LZ575_RS14750	COG1629	transport
LZ575_RS14760	COG0673	inositol 2-dehydrogenase activity
LZ575_RS14765	COG0673	inositol 2-dehydrogenase activity
LZ575_RS14810	COG0702	epimerase
LZ575_RS14820	COG1629	transport
LZ575_RS14825	COG4771	TonB-dependent receptor
LZ575_RS14875	COG3291	Pkd domain containing protein
LZ575_RS14875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LZ575_RS14895	COG1629	transport
LZ575_RS14900	COG4771	TonB-dependent receptor
LZ575_RS14905	COG2222	sugar isomerase
LZ575_RS14910	COG2222	sugar isomerase
LZ575_RS14915	COG1105	Belongs to the carbohydrate kinase PfkB family
LZ575_RS14920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LZ575_RS14935	COG0673	inositol 2-dehydrogenase activity
LZ575_RS14940	COG1349	DNA-binding transcription factor activity
LZ575_RS14945	COG1349	DNA-binding transcription factor activity
LZ575_RS14955	COG0481	GTPase activity
LZ575_RS14960	COG3263	regulation of cellular component size
LZ575_RS14965	COG0475	glutathione-regulated potassium exporter activity
LZ575_RS14965	COG0589	response to stress
LZ575_RS14980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LZ575_RS14995	COG0594	ribonuclease P activity
LZ575_RS15000	COG0793	Belongs to the peptidase S41A family
LZ575_RS15005	COG2153	protein acetylation
LZ575_RS15010	COG0698	ribose 5-phosphate isomerase
LZ575_RS15020	COG0557	exoribonuclease II activity
LZ575_RS15075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LZ575_RS15090	COG0445	tRNA wobble uridine modification
LZ575_RS15095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LZ575_RS15130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LZ575_RS15150	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LZ575_RS15165	COG1215	transferase activity, transferring glycosyl groups
LZ575_RS15175	COG0004	ammonium transporteR
LZ575_RS15220	COG0859	PFAM glycosyl transferase family 9
LZ575_RS15225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LZ575_RS15270	COG0356	it plays a direct role in the translocation of protons across the membrane
LZ575_RS15275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LZ575_RS15280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LZ575_RS15320	COG0756	dUTP diphosphatase activity
LZ575_RS15345	COG1607	acyl-coa hydrolase
LZ575_RS15400	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LZ575_RS15450	COG0823	Involved in the tonB-independent uptake of proteins
LZ575_RS15450	COG1506	peptidase
LZ575_RS15485	COG4221	oxidoreductase activity
LZ575_RS15515	COG2304	oxidoreductase activity
LZ575_RS15545	COG0288	reversible hydration of carbon dioxide
LZ575_RS15565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LZ575_RS15580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LZ575_RS15585	COG1652	LysM domain
LZ575_RS15590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LZ575_RS15595	COG0194	GDP metabolic process
LZ575_RS15600	COG1561	YicC-like family, N-terminal region
LZ575_RS15615	COG0697	spore germination
LZ575_RS15630	COG0626	cystathionine gamma-synthase activity
LZ575_RS15670	COG2161	toxin-antitoxin pair type II binding
LZ575_RS15675	COG4115	mRNA cleavage
LZ575_RS15700	COG0577	efflux transmembrane transporter activity
LZ575_RS15735	COG0110	maltose O-acetyltransferase activity
LZ575_RS15740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LZ575_RS15755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LZ575_RS15760	COG3279	Response regulator of the LytR AlgR family
LZ575_RS15765	COG2198	Histidine kinase
LZ575_RS15765	COG0643	Histidine kinase
LZ575_RS15775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LZ575_RS15810	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LZ575_RS15830	COG0166	Belongs to the GPI family
LZ575_RS15835	COG4771	TonB-dependent receptor
LZ575_RS15850	COG1418	mRNA catabolic process
LZ575_RS15885	COG4771	TonB-dependent receptor
LZ575_RS15925	COG1999	signal sequence binding
LZ575_RS15930	COG0750	zinc metalloprotease
LZ575_RS15935	COG2382	esterase
LZ575_RS15945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LZ575_RS15950	COG1335	isochorismatase
LZ575_RS15955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LZ575_RS16000	COG2353	YceI-like domain
LZ575_RS16025	COG4206	TonB-dependent receptor
LZ575_RS16025	COG1629	transport
LZ575_RS16045	COG4771	TonB-dependent receptor
LZ575_RS16075	COG1501	Belongs to the glycosyl hydrolase 31 family
LZ575_RS16080	COG1082	Xylose isomerase domain protein TIM barrel
LZ575_RS16085	COG1082	Xylose isomerase domain protein TIM barrel
LZ575_RS16095	COG0673	inositol 2-dehydrogenase activity
LZ575_RS16140	COG1629	transport
LZ575_RS16150	COG1609	Transcriptional regulator
LZ575_RS16230	COG2095	MarC family integral membrane protein
LZ575_RS16240	COG0492	ferredoxin-NADP+ reductase activity
LZ575_RS16320	COG0494	nUDIX hydrolase
LZ575_RS16335	COG1061	Type III restriction enzyme res subunit
LZ575_RS16385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ575_RS16395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LZ575_RS16410	COG4974	Belongs to the 'phage' integrase family
LZ575_RS16420	COG5002	protein histidine kinase activity
LZ575_RS16435	COG0745	RESPONSE REGULATOR receiver
LZ575_RS16435	COG2205	protein histidine kinase activity
LZ575_RS16435	COG3292	Two component regulator propeller
LZ575_RS16440	COG4771	TonB-dependent receptor
LZ575_RS16445	COG0702	epimerase
LZ575_RS16465	COG3119	arylsulfatase activity
LZ575_RS16480	COG0405	Gamma-glutamyltransferase
LZ575_RS16575	COG1793	dna ligase
LZ575_RS16580	COG3285	dna ligase
LZ575_RS16580	COG1793	dna ligase
LZ575_RS16585	COG3285	dna ligase
LZ575_RS16585	COG1793	dna ligase
LZ575_RS16595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LZ575_RS16600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LZ575_RS16620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LZ575_RS16640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LZ575_RS16645	COG2239	Acts as a magnesium transporter
LZ575_RS16665	COG4895	conserved protein (DUF2196)
LZ575_RS16715	COG2852	Protein conserved in bacteria
LZ575_RS16730	COG3387	PFAM Glycoside hydrolase 15-related
LZ575_RS16735	COG1063	alcohol dehydrogenase
LZ575_RS16785	COG0792	nuclease activity
LZ575_RS16795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZ575_RS16795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LZ575_RS16800	COG2827	Endonuclease containing a URI domain
LZ575_RS16815	COG0612	Peptidase, M16
LZ575_RS16825	COG3291	Pkd domain containing protein
LZ575_RS16830	COG3291	Pkd domain containing protein
LZ575_RS16835	COG0629	single-stranded DNA binding
LZ575_RS16840	COG0513	Belongs to the DEAD box helicase family
LZ575_RS16890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LZ575_RS16935	COG0673	inositol 2-dehydrogenase activity
LZ575_RS16945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ575_RS16950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ575_RS16960	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS16970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LZ575_RS16970	COG0617	tRNA 3'-terminal CCA addition
LZ575_RS16970	COG0517	IMP dehydrogenase activity
LZ575_RS17000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LZ575_RS17005	COG1278	Cold shock
LZ575_RS17015	COG0038	chloride channel
LZ575_RS17030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LZ575_RS17105	COG0811	peptide transport
LZ575_RS17175	COG0233	cytoplasmic translational termination
LZ575_RS17180	COG0528	UMP kinase activity
LZ575_RS17185	COG2738	Putative neutral zinc metallopeptidase
LZ575_RS17190	COG1528	Iron-storage protein
LZ575_RS17200	COG1522	sequence-specific DNA binding
LZ575_RS17260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LZ575_RS17295	COG1629	transport
LZ575_RS17295	COG4206	TonB-dependent receptor
LZ575_RS17300	COG0745	RESPONSE REGULATOR receiver
LZ575_RS17305	COG5002	protein histidine kinase activity
LZ575_RS17315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LZ575_RS17345	COG0633	Ferredoxin
LZ575_RS17355	COG1960	acyl-CoA dehydrogenase activity
LZ575_RS17385	COG3279	Response regulator of the LytR AlgR family
LZ575_RS17390	COG3275	phosphorelay sensor kinase activity
LZ575_RS17405	COG3118	belongs to the thioredoxin family
LZ575_RS17425	COG4974	Belongs to the 'phage' integrase family
LZ575_RS17480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS17540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LZ575_RS17595	COG0569	domain protein
LZ575_RS17600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LZ575_RS17680	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS17740	COG4771	TonB-dependent receptor
LZ575_RS17760	COG1349	DNA-binding transcription factor activity
LZ575_RS17770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LZ575_RS17775	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LZ575_RS17780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LZ575_RS17785	COG4206	TonB-dependent receptor
LZ575_RS17785	COG1629	transport
LZ575_RS17790	COG4206	TonB-dependent receptor
LZ575_RS17790	COG1629	transport
LZ575_RS17830	COG3537	Alpha-1,2-mannosidase
LZ575_RS17845	COG4771	TonB-dependent receptor
LZ575_RS17855	COG4771	TonB-dependent receptor
LZ575_RS17865	COG0702	epimerase
LZ575_RS17880	COG2814	Major facilitator Superfamily
LZ575_RS17885	COG1940	carbohydrate kinase activity
LZ575_RS17915	COG2382	esterase
LZ575_RS17925	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ575_RS17955	COG1629	transport
LZ575_RS17960	COG4771	TonB-dependent receptor
LZ575_RS17965	COG0702	epimerase
LZ575_RS17990	COG1331	Highly conserved protein containing a thioredoxin domain
LZ575_RS18000	COG2115	Belongs to the xylose isomerase family
LZ575_RS18005	COG1070	Carbohydrate kinase
LZ575_RS18010	COG0477	Major facilitator Superfamily
LZ575_RS18010	COG2814	Major facilitator Superfamily
LZ575_RS18030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LZ575_RS18055	COG1904	glucuronate isomerase
LZ575_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS18095	COG0667	Aldo Keto reductase
LZ575_RS18115	COG4771	TonB-dependent receptor
LZ575_RS18230	COG3275	phosphorelay sensor kinase activity
LZ575_RS18240	COG3279	Response regulator of the LytR AlgR family
LZ575_RS18320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LZ575_RS18375	COG0179	Fumarylacetoacetate (FAA) hydrolase
LZ575_RS18400	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS18405	COG0738	Major facilitator superfamily
LZ575_RS18410	COG3254	rhamnose metabolic process
LZ575_RS18415	COG0247	lactate metabolic process
LZ575_RS18420	COG1139	Iron-sulfur cluster binding protein
LZ575_RS18430	COG3279	Response regulator of the LytR AlgR family
LZ575_RS18465	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
LZ575_RS18500	COG4771	TonB-dependent receptor
LZ575_RS18525	COG1472	Belongs to the glycosyl hydrolase 3 family
LZ575_RS18540	COG1446	asparaginase
LZ575_RS18555	COG1629	transport
LZ575_RS18560	COG1629	transport
LZ575_RS18560	COG4206	TonB-dependent receptor
LZ575_RS18590	COG3250	beta-galactosidase activity
LZ575_RS18605	COG3940	Belongs to the glycosyl hydrolase 43 family
LZ575_RS18635	COG4297	protein containing double-stranded beta helix domain
LZ575_RS18655	COG5002	protein histidine kinase activity
LZ575_RS18695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LZ575_RS18700	COG1085	galactose-1-phosphate uridylyltransferase
LZ575_RS18710	COG1609	Transcriptional regulator
LZ575_RS18725	COG4221	oxidoreductase activity
LZ575_RS18740	COG1105	Belongs to the carbohydrate kinase PfkB family
LZ575_RS18745	COG0514	ATP-dependent DNA helicase (RecQ)
LZ575_RS18750	COG0514	ATP-dependent DNA helicase (RecQ)
LZ575_RS18755	COG0629	single-stranded DNA binding
LZ575_RS18810	COG4771	TonB-dependent receptor
LZ575_RS18815	COG4771	TonB-dependent receptor
LZ575_RS18845	COG1629	transport
LZ575_RS18845	COG4206	TonB-dependent receptor
LZ575_RS18850	COG0702	epimerase
LZ575_RS18875	COG1082	Xylose isomerase domain protein TIM barrel
LZ575_RS18905	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ575_RS18910	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ575_RS18930	COG2382	esterase
LZ575_RS18935	COG2382	esterase
LZ575_RS18935	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ575_RS18935	COG3693	PFAM glycoside hydrolase, family 10
LZ575_RS18945	COG2382	esterase
LZ575_RS18945	COG3693	PFAM glycoside hydrolase, family 10
LZ575_RS18950	COG0745	RESPONSE REGULATOR receiver
LZ575_RS18950	COG3292	Two component regulator propeller
LZ575_RS18950	COG2205	protein histidine kinase activity
LZ575_RS18955	COG2205	protein histidine kinase activity
LZ575_RS18955	COG3292	Two component regulator propeller
LZ575_RS18955	COG0745	RESPONSE REGULATOR receiver
LZ575_RS19000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LZ575_RS19070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LZ575_RS19095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LZ575_RS19115	COG0628	permease
LZ575_RS19130	COG4242	Belongs to the peptidase S51 family
LZ575_RS19140	COG1446	asparaginase
LZ575_RS19150	COG3118	belongs to the thioredoxin family
LZ575_RS19175	COG0038	chloride channel
LZ575_RS19185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LZ575_RS19225	COG0427	acetyl-CoA hydrolase
LZ575_RS19300	COG5002	protein histidine kinase activity
LZ575_RS19325	COG3256	nitric oxide reductase
LZ575_RS19340	COG0745	RESPONSE REGULATOR receiver
LZ575_RS19375	COG0779	Required for maturation of 30S ribosomal subunits
LZ575_RS19385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LZ575_RS19435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LZ575_RS19440	COG2255	four-way junction helicase activity
LZ575_RS19450	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LZ575_RS19470	COG0509	glycine decarboxylation via glycine cleavage system
LZ575_RS19490	COG0109	protoheme IX farnesyltransferase activity
LZ575_RS19495	COG1845	cytochrome c oxidase, subunit III
LZ575_RS19520	COG2322	membrane
LZ575_RS19530	COG1136	(ABC) transporter
LZ575_RS19535	COG1136	(ABC) transporter
LZ575_RS19535	COG0577	efflux transmembrane transporter activity
LZ575_RS19540	COG0577	efflux transmembrane transporter activity
LZ575_RS19540	COG1136	(ABC) transporter
LZ575_RS19545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LZ575_RS19565	COG0668	transmembrane transport
LZ575_RS19610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LZ575_RS19620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LZ575_RS19630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LZ575_RS19635	COG0596	Alpha beta hydrolase
LZ575_RS19650	COG1950	PFAM Membrane protein of
LZ575_RS19655	COG0544	peptidyl-prolyl cis-trans isomerase activity
LZ575_RS19665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LZ575_RS19670	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LZ575_RS19685	COG4106	trans-aconitate 2-methyltransferase activity
LZ575_RS19845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LZ575_RS19875	COG0488	(ABC) transporter
LZ575_RS19930	COG0582	viral genome integration into host DNA
LZ575_RS20005	COG3328	transposase activity
LZ575_RS20035	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
LZ575_RS20040	COG4221	oxidoreductase activity
LZ575_RS20110	COG5002	protein histidine kinase activity
LZ575_RS20175	COG1104	cysteine desulfurase activity
LZ575_RS20180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LZ575_RS20195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LZ575_RS20210	COG4771	TonB-dependent receptor
LZ575_RS20215	COG4771	TonB-dependent receptor
LZ575_RS20225	COG4771	TonB-dependent receptor
LZ575_RS20290	COG1538	Outer membrane efflux protein
LZ575_RS20310	COG0577	efflux transmembrane transporter activity
LZ575_RS20325	COG0577	efflux transmembrane transporter activity
LZ575_RS20345	COG0577	efflux transmembrane transporter activity
LZ575_RS20375	COG0577	efflux transmembrane transporter activity
LZ575_RS20375	COG1136	(ABC) transporter
LZ575_RS20385	COG0577	efflux transmembrane transporter activity
LZ575_RS20390	COG0577	efflux transmembrane transporter activity
LZ575_RS20390	COG1136	(ABC) transporter
LZ575_RS20460	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LZ575_RS20510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LZ575_RS20535	COG1428	Deoxynucleoside kinase
LZ575_RS20580	COG2755	lipolytic protein G-D-S-L family
LZ575_RS20580	COG0657	acetylesterase activity
LZ575_RS20585	COG1119	ATPase activity
LZ575_RS20635	COG0745	RESPONSE REGULATOR receiver
LZ575_RS20675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LZ575_RS20705	COG2226	methyltransferase
LZ575_RS20710	COG0569	domain protein
LZ575_RS20715	COG0436	Aminotransferase
LZ575_RS20720	COG3239	Fatty acid desaturase
LZ575_RS20725	COG0357	Ribosomal RNA small subunit methyltransferase G
LZ575_RS20740	COG0723	plastoquinol--plastocyanin reductase activity
LZ575_RS20740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LZ575_RS20745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LZ575_RS20910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LZ575_RS20930	COG0740	serine-type endopeptidase activity
LZ575_RS20945	COG2066	Belongs to the glutaminase family
LZ575_RS20990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LZ575_RS21035	COG3263	regulation of cellular component size
LZ575_RS21040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LZ575_RS21060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LZ575_RS21085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LZ575_RS21110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LZ575_RS21115	COG0436	Aminotransferase
LZ575_RS21125	COG0525	valine-tRNA ligase activity
LZ575_RS21140	COG4589	Belongs to the CDS family
LZ575_RS21150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LZ575_RS21155	COG0799	negative regulation of ribosome biogenesis
LZ575_RS21160	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LZ575_RS21160	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LZ575_RS21170	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LZ575_RS21175	COG0494	nUDIX hydrolase
LZ575_RS21190	COG4771	TonB-dependent receptor
LZ575_RS21200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LZ575_RS21250	COG0133	tryptophan synthase activity
LZ575_RS21255	COG0135	phosphoribosylanthranilate isomerase activity
LZ575_RS21260	COG0134	indole-3-glycerol-phosphate synthase activity
LZ575_RS21280	COG2353	YceI-like domain
LZ575_RS21285	COG0778	Nitroreductase
LZ575_RS21295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LZ575_RS21300	COG1054	Belongs to the UPF0176 family
LZ575_RS21360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LZ575_RS21365	COG0714	Associated with various cellular activities
LZ575_RS21385	COG3620	sequence-specific DNA binding
LZ575_RS21390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LZ575_RS21410	COG1233	COG1233 Phytoene dehydrogenase and related
LZ575_RS21440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LZ575_RS21445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LZ575_RS21485	COG0825	malonyl-CoA metabolic process
LZ575_RS21515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LZ575_RS21520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LZ575_RS21525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LZ575_RS21585	COG0336	Belongs to the RNA methyltransferase TrmD family
LZ575_RS21615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LZ575_RS21620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LZ575_RS21630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LZ575_RS21640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LZ575_RS21650	COG1739	Uncharacterized protein family UPF0029
LZ575_RS21695	COG0737	Belongs to the 5'-nucleotidase family
LZ575_RS21700	COG1525	nuclease
LZ575_RS21700	COG4085	toxin activity
LZ575_RS21700	COG0737	Belongs to the 5'-nucleotidase family
LZ575_RS21740	COG0497	DNA recombination
LZ575_RS21745	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LZ575_RS21760	COG0237	dephospho-CoA kinase activity
LZ575_RS21805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LZ575_RS21810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LZ575_RS21825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LZ575_RS21845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LZ575_RS21855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LZ575_RS21875	COG2514	catechol 2,3-dioxygenase activity
LZ575_RS21880	COG2514	catechol 2,3-dioxygenase activity
LZ575_RS21885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LZ575_RS21900	COG0346	lactoylglutathione lyase activity
LZ575_RS21905	COG0346	lactoylglutathione lyase activity
LZ575_RS21980	COG0175	sulfate reduction
LZ575_RS22025	COG0606	chelatase, subunit chli
LZ575_RS22045	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LZ575_RS22075	COG4585	Histidine kinase
LZ575_RS22085	COG3153	acetyltransferase
LZ575_RS22085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LZ575_RS22100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LZ575_RS22105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LZ575_RS22110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LZ575_RS22120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LZ575_RS22130	COG0165	Argininosuccinate lyase
LZ575_RS22155	COG2244	polysaccharide biosynthetic process
LZ575_RS22180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LZ575_RS22195	COG0628	permease
LZ575_RS22220	COG0531	amino acid
LZ575_RS22255	COG1640	4-alpha-glucanotransferase
LZ575_RS22260	COG1640	4-alpha-glucanotransferase
LZ575_RS22340	COG0352	thiamine-phosphate diphosphorylase activity
LZ575_RS22345	COG0352	thiamine-phosphate diphosphorylase activity
LZ575_RS22350	COG1131	(ABC) transporter
LZ575_RS22380	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS22415	COG0745	RESPONSE REGULATOR receiver
LZ575_RS22425	COG0438	transferase activity, transferring glycosyl groups
LZ575_RS22460	COG1690	Belongs to the RtcB family
LZ575_RS22480	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS22485	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS22510	COG1484	DNA-dependent DNA replication
LZ575_RS22515	COG1484	DNA-dependent DNA replication
LZ575_RS22550	COG0303	'Molybdopterin
LZ575_RS22555	COG0243	molybdopterin cofactor binding
LZ575_RS22560	COG0243	molybdopterin cofactor binding
LZ575_RS22595	COG2333	competence protein COMEC
LZ575_RS22595	COG0658	competence protein
LZ575_RS22625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LZ575_RS22625	COG2010	Cytochrome c
LZ575_RS22700	COG2272	Belongs to the type-B carboxylesterase lipase family
LZ575_RS22715	COG4771	TonB-dependent receptor
LZ575_RS22740	COG4771	TonB-dependent receptor
LZ575_RS22750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LZ575_RS22755	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LZ575_RS22770	COG1028	Short-chain dehydrogenase reductase Sdr
LZ575_RS22805	COG3661	Belongs to the glycosyl hydrolase 67 family
LZ575_RS22810	COG3661	Belongs to the glycosyl hydrolase 67 family
LZ575_RS22825	COG0667	Aldo Keto reductase
LZ575_RS22850	COG4771	TonB-dependent receptor
LZ575_RS22855	COG1629	transport
LZ575_RS22875	COG3537	Alpha-1,2-mannosidase
LZ575_RS22900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LZ575_RS22905	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LZ575_RS22945	COG1082	Xylose isomerase domain protein TIM barrel
LZ575_RS22950	COG3507	Belongs to the glycosyl hydrolase 43 family
LZ575_RS22965	COG2382	esterase
LZ575_RS22990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LZ575_RS22995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons