locus-tag	class	description
aq_001	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
aq_005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
aq_008	COG0051	transcription antitermination factor activity, RNA binding
aq_009	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
aq_011	COG0088	Forms part of the polypeptide exit tunnel
aq_012	COG0089	rRNA binding
aq_013	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
aq_015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
aq_016a	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
aq_017	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
aq_018	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
aq_020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
aq_021	COG0710	3-dehydroquinate dehydratase activity
aq_023	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
aq_025	COG0772	Belongs to the SEDS family
aq_027	COG5001	Diguanylate cyclase
aq_027	COG3300	MHYT domain
aq_030	COG0303	'Molybdopterin
aq_031	COG0471	metal ion transport
aq_035	COG3706	GGDEF domain
aq_036	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
aq_038	COG2084	Dehydrogenase
aq_039	COG0131	Imidazoleglycerol-phosphate dehydratase
aq_041	COG0792	nuclease activity
aq_044	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
aq_046	COG0167	dihydroorotate dehydrogenase activity
aq_049	COG2154	pterin-4-alpha-carbinolamine dehydratase
aq_052	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
aq_053	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
aq_054	COG4752	Belongs to the RNA methyltransferase TrmD family
aq_056	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
aq_057	COG1489	DNA binding
aq_061	COG0521	Mo-molybdopterin cofactor biosynthetic process
aq_062	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
aq_063	COG0360	Binds together with S18 to 16S ribosomal RNA
aq_064	COG0629	single-stranded DNA binding
aq_064a	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
aq_064b	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
aq_064c	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
aq_065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
aq_067	COG0437	4 iron, 4 sulfur cluster binding
aq_069	COG0203	ribosomal protein L17
aq_070	COG0202	RNA polymerase activity
aq_072	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
aq_073	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
aq_074	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
aq_075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
aq_075a	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
aq_076	COG0024	Methionine aminopeptidase
aq_078	COG0563	adenylate kinase activity
aq_079	COG0201	protein transport
aq_080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
aq_081	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
aq_083	COG3300	MHYT domain
aq_083	COG5001	Diguanylate cyclase
aq_085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
aq_094	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
aq_098	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
aq_099	COG2890	protein-(glutamine-N5) methyltransferase activity
aq_1001	COG1360	Flagellar Motor Protein
aq_1002	COG1360	Flagellar Motor Protein
aq_1003	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
aq_1005	COG1324	tolerance protein
aq_1006	COG0419	ATPase involved in DNA repair
aq_1008	COG0587	DNA-directed DNA polymerase activity
aq_1013	COG1196	nuclear chromosome segregation
aq_1013	COG3264	Mechanosensitive ion channel
aq_1015	COG0826	peptidase U32
aq_1019	COG0309	Hydrogenase expression formation protein (HypE)
aq_1021	COG0375	protein maturation
aq_1023	COG0123	including yeast histone deacetylase and acetoin utilization protein
aq_1024	COG0589	response to stress
aq_1026	COG0187	DNA topoisomerase II activity
aq_103	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
aq_1030	COG0709	Synthesizes selenophosphate from selenide and ATP
aq_1031	COG1921	L-seryl-tRNASec selenium transferase activity
aq_1038	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
aq_1038	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
aq_104	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
aq_1046	COG0437	4 iron, 4 sulfur cluster binding
aq_1050	COG2032	superoxide dismutase activity
aq_1051	COG3058	Necessary for formate dehydrogenase activity
aq_1052	COG0509	glycine decarboxylation via glycine cleavage system
aq_1054	COG1408	metallophosphoesterase
aq_1055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
aq_1057	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
aq_1059	COG1538	Outer membrane efflux protein
aq_1065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
aq_1067	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
aq_1067a	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
aq_1068	COG0215	cysteine-tRNA ligase activity
aq_106a	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
aq_1071	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
aq_1078	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
aq_1081	COG2046	Belongs to the sulfate adenylyltransferase family
aq_1081	COG0529	Catalyzes the synthesis of activated sulfate
aq_1082	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
aq_1088	COG0457	Tetratricopeptide repeat
aq_108b	COG1923	regulation of RNA biosynthetic process
aq_109	COG0347	Belongs to the P(II) protein family
aq_1099	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
aq_1101	COG0416	fatty acid biosynthetic process
aq_1102	COG0333	Belongs to the bacterial ribosomal protein bL32 family
aq_1103	COG1399	metal-binding, possibly nucleic acid-binding protein
aq_1104	COG1466	dna polymerase III delta subunit
aq_1105	COG0047	phosphoribosylformylglycinamidine synthase activity
aq_1108	COG0509	glycine decarboxylation via glycine cleavage system
aq_1109	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
aq_111	COG0174	glutamine synthetase
aq_1111	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
aq_1115	COG4191	Histidine kinase
aq_1117	COG2204	response regulator
aq_112	COG0004	ammonium transporteR
aq_1125	COG2217	Heavy metal translocating P-type atpase
aq_113	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
aq_1130	COG2132	Multicopper oxidase
aq_1134	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
aq_1138	COG0698	ribose 5-phosphate isomerase
aq_1140	COG0137	argininosuccinate synthase activity
aq_1141	COG0438	transferase activity, transferring glycosyl groups
aq_1143	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
aq_1144	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
aq_1145	COG1454	alcohol dehydrogenase
aq_1151	COG3300	MHYT domain
aq_1151	COG5001	Diguanylate cyclase
aq_1152	COG0527	aspartate kinase activity
aq_1154	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
aq_1155	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
aq_1156	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
aq_1156	COG1024	Enoyl-CoA hydratase
aq_1159	COG1110	DNA topoisomerase II activity
aq_116	COG3383	formate dehydrogenase (NAD+) activity
aq_1168	COG1013	pyruvate-flavodoxin oxidoreductase activity
aq_1171a	COG1144	Oxidoreductase
aq_1172	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
aq_1173	COG2062	phosphohistidine phosphatase, SixA
aq_1174	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
aq_1175	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
aq_1177	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
aq_1178	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
aq_118	COG0126	phosphoglycerate kinase activity
aq_1180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
aq_1182	COG1766	The M ring may be actively involved in energy transduction
aq_1182a	COG1677	Flagellar hook-basal body complex protein FliE
aq_1183	COG1558	bacterial-type flagellum-dependent cell motility
aq_1184	COG1815	bacterial-type flagellum-dependent cell motility
aq_1189	COG0768	penicillin binding
aq_119	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
aq_1191	COG0758	DNA mediated transformation
aq_1191	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
aq_1192a	COG1144	Oxidoreductase
aq_1195	COG0674	pyruvate-flavodoxin oxidoreductase activity
aq_1196	COG1013	pyruvate-flavodoxin oxidoreductase activity
aq_1202	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
aq_1204	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
aq_1206	COG0825	malonyl-CoA metabolic process
aq_1208	COG0019	diaminopimelate decarboxylase activity
aq_121	COG0644	oxidoreductase
aq_1210	COG0390	transport system, permease component
aq_1211	COG3706	GGDEF domain
aq_1212	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
aq_1214	COG1419	protein localization to endoplasmic reticulum
aq_1218	COG1191	sigma factor activity
aq_122	COG0124	histidyl-tRNA synthetase
aq_1220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
aq_1221	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
aq_1222	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
aq_1224	COG0482	sulfurtransferase activity
aq_1226	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
aq_1229	COG2814	Major facilitator Superfamily
aq_123	COG0228	four-way junction DNA binding
aq_1231	COG3302	dmso reductase anchor subunit
aq_1232	COG0437	4 iron, 4 sulfur cluster binding
aq_1234	COG0243	molybdopterin cofactor binding
aq_1239	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
aq_1240	COG1028	Short-chain dehydrogenase reductase Sdr
aq_1242	COG1193	negative regulation of DNA recombination
aq_1245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
aq_1248	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
aq_1249	COG0575	Belongs to the CDS family
aq_124a	COG1837	Belongs to the UPF0109 family
aq_1250	COG1881	PFAM PEBP family protein
aq_1254	COG1862	Preprotein translocase
aq_1255	COG1918	ferrous iron import across plasma membrane
aq_1255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
aq_1256	COG3659	wide pore channel activity
aq_1257	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
aq_1258	COG1477	protein flavinylation
aq_1259	COG1730	sister chromatid segregation
aq_1262	COG2010	Cytochrome c
aq_1265	COG1966	Carbon starvation protein
aq_1267	COG0805	protein transport
aq_1271	COG0612	Peptidase, M16
aq_1272	COG0799	negative regulation of ribosome biogenesis
aq_1273	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
aq_1279	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
aq_128	COG0534	Mate efflux family protein
aq_1281	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
aq_1283	COG0071	Belongs to the small heat shock protein (HSP20) family
aq_1285	COG1459	type II secretion system
aq_1290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
aq_1292	COG1618	nucleotide phosphatase activity, acting on free nucleotides
aq_1293	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
aq_1296	COG0542	response to heat
aq_1300	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
aq_1303	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
aq_1303a	COG1278	Cold shock
aq_1305	COG0543	2 iron, 2 sulfur cluster binding
aq_1308	COG0343	queuine tRNA-ribosyltransferase activity
aq_1309	COG0083	homoserine kinase activity
aq_1310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
aq_1312	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
aq_1314	COG0649	NAD binding
aq_1314	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
aq_1315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
aq_1317	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
aq_1319	COG0713	ATP synthesis coupled electron transport
aq_132	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
aq_1322	COG1007	ATP synthesis coupled electron transport
aq_1323	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
aq_1329	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
aq_133	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
aq_1331	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
aq_1333	COG0037	tRNA processing
aq_1334	COG0504	CTP synthase activity
aq_1335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
aq_1336	COG1355	regulation of microtubule-based process
aq_1337	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
aq_1339	COG0740	serine-type endopeptidase activity
aq_1340	COG0544	peptidyl-prolyl cis-trans isomerase activity
aq_1342	COG0546	phosphoglycolate phosphatase activity
aq_1345	COG1842	Phage shock protein A
aq_1349	COG3766	membrane
aq_135	COG0702	epimerase
aq_1350	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
aq_1351	COG1702	phosphate starvation-inducible protein PhoH
aq_1354	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
aq_1355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
aq_1357	COG1271	oxidase subunit
aq_1358	COG1294	oxidase, subunit
aq_1359	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
aq_1360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
aq_1362	COG0604	alcohol dehydrogenase
aq_1363	COG0511	ligase activity, forming carbon-carbon bonds
aq_1364	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
aq_1365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
aq_1365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
aq_1366	COG0352	thiamine-phosphate diphosphorylase activity
aq_1367	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
aq_1367	COG1213	nucleotidyl transferase
aq_1370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
aq_1372	COG0165	Argininosuccinate lyase
aq_1375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
aq_1378	COG0713	ATP synthesis coupled electron transport
aq_138	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
aq_138	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
aq_1382	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
aq_1383	COG1007	ATP synthesis coupled electron transport
aq_1386	COG1752	Esterase of the alpha-beta hydrolase superfamily
aq_139	COG0196	riboflavin kinase activity
aq_1390	COG0191	fructose-bisphosphate aldolase activity
aq_1391	COG3039	Transposase
aq_1394	COG1793	dna ligase
aq_1398	COG0066	3-isopropylmalate dehydratase activity
aq_1401	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
aq_1404	COG1192	Involved in chromosome partitioning
aq_1407	COG1215	transferase activity, transferring glycosyl groups
aq_141	COG0537	adenosine 5'-monophosphoramidase activity
aq_1410	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
aq_1413	COG0525	valine-tRNA ligase activity
aq_1419	COG0746	molybdenum cofactor guanylyltransferase activity
aq_1420	COG0741	lytic transglycosylase activity
aq_1421	COG0425	Belongs to the sulfur carrier protein TusA family
aq_1422	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
aq_1422	COG1796	DNA polymerase
aq_1423	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
aq_1424	COG0635	Involved in the biosynthesis of porphyrin-containing compound
aq_1427	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
aq_1429	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
aq_1434	COG4969	Belongs to the N-Me-Phe pilin family
aq_1436	COG4968	Prepilin-type N-terminal cleavage methylation domain
aq_1442	COG3300	MHYT domain
aq_1442	COG5001	Diguanylate cyclase
aq_1444	COG2078	PFAM AMMECR1 domain protein
aq_1445	COG2217	Heavy metal translocating P-type atpase
aq_145	COG0859	PFAM glycosyl transferase family 9
aq_1450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
aq_1452	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
aq_1453	COG3287	FIST C domain
aq_1455	COG3706	GGDEF domain
aq_1457	COG2226	methyltransferase
aq_1464	COG1187	pseudouridine synthase activity
aq_1467	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
aq_1468	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
aq_1470	COG0439	Biotin carboxylase
aq_1472	COG0305	Participates in initiation and elongation during chromosome replication
aq_1476	COG1579	Zn-ribbon protein possibly nucleic acid-binding
aq_1478	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
aq_148	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
aq_1480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
aq_1482	COG0456	acetyltransferase
aq_1483	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
aq_1484a	COG0776	regulation of translation
aq_1485	COG0539	negative regulation of cytoplasmic translation
aq_1489	COG0336	Belongs to the RNA methyltransferase TrmD family
aq_1490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
aq_1493	COG0358	DNA primase activity
aq_1494	COG0824	Thioesterase
aq_1498	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
aq_1499	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
aq_1503	COG0569	domain protein
aq_1504	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
aq_1505	COG1372	Participates in initiation and elongation during chromosome replication
aq_1505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
aq_1509	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
aq_1512	COG0538	isocitrate dehydrogenase activity
aq_1517	COG0439	Biotin carboxylase
aq_152	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
aq_1520	COG5016	pyruvate
aq_1520	COG0511	ligase activity, forming carbon-carbon bonds
aq_1527	COG1774	PSP1 C-terminal conserved region
aq_1528	COG0820	rRNA (adenine-C2-)-methyltransferase activity
aq_1530	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
aq_1531	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
aq_1534	COG3009	Protein conserved in bacteria
aq_1535	COG0006	proline dipeptidase activity
aq_1536	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
aq_1539	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
aq_154	COG0109	protoheme IX farnesyltransferase activity
aq_1540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
aq_1546	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
aq_1546	COG0517	IMP dehydrogenase activity
aq_1547	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
aq_1548	COG0159	tryptophan synthase activity
aq_155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
aq_1552	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
aq_1554	COG1830	Aldolase
aq_1556	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
aq_156	COG2322	membrane
aq_1560	COG1100	Small GTP-binding protein
aq_1563	COG1132	(ABC) transporter
aq_1565	COG0070	glutamate synthase
aq_1565	COG0067	glutamate synthase
aq_1565	COG0069	glutamate synthase activity
aq_1569	COG2270	Major facilitator Superfamily
aq_157	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
aq_1575	COG0217	transcriptional regulatory protein
aq_1578	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
aq_1580	COG0284	orotidine-5'-phosphate decarboxylase activity
aq_1582	COG0357	Ribosomal RNA small subunit methyltransferase G
aq_1585	COG4591	ABC-type transport system involved in lipoprotein release permease component
aq_1587	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
aq_1588	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
aq_1590	COG0105	UTP biosynthetic process
aq_1595	COG1157	protein secretion by the type III secretion system
aq_1598	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
aq_1599	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
aq_1602	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
aq_1603	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
aq_1606	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
aq_1607	COG0717	Belongs to the dCTP deaminase family
aq_1610	COG2003	Belongs to the UPF0758 family
aq_1612	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
aq_1613	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
aq_1614	COG5016	pyruvate
aq_1614	COG0511	ligase activity, forming carbon-carbon bonds
aq_1618	COG0658	competence protein
aq_162	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
aq_1620	COG0045	succinate-CoA ligase (ADP-forming) activity
aq_1622	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
aq_1628	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
aq_1629	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
aq_1630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
aq_1632	COG1509	lysine 2,3-aminomutase activity
aq_1634	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
aq_1636	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
aq_1638	COG0095	Lipoate-protein ligase
aq_1639	COG0247	lactate metabolic process
aq_164	COG2204	response regulator
aq_1640	COG3039	Transposase
aq_1641	COG0438	transferase activity, transferring glycosyl groups
aq_1641a	COG0261	This protein binds to 23S rRNA in the presence of protein L20
aq_1642	COG0200	Binds to the 23S rRNA
aq_1644	COG1841	ribosomal large subunit assembly
aq_1645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
aq_1648	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
aq_1649	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
aq_165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
aq_1651	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
aq_1651a	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
aq_1652	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
aq_1653	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
aq_1654	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
aq_1656	COG1663	tetraacyldisaccharide 4'-kinase activity
aq_1657	COG0509	glycine decarboxylation via glycine cleavage system
aq_1659	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
aq_166	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
aq_1660	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
aq_1661	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
aq_1664	COG0439	Biotin carboxylase
aq_1665	COG0039	L-malate dehydrogenase activity
aq_1667	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
aq_167	COG1496	oxidoreductase activity
aq_1671	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
aq_1672	COG0542	response to heat
aq_1677	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
aq_1679	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
aq_1679	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
aq_1680	COG3334	PFAM MgtE intracellular
aq_1681	COG0860	N-Acetylmuramoyl-L-alanine amidase
aq_1693	COG1573	uracil-dna glycosylase
aq_1694	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
aq_1695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
aq_1695a	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
aq_170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
aq_1707	COG0307	riboflavin synthase, alpha
aq_1708	COG0205	6-phosphofructokinase activity
aq_1710	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
aq_1711	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
aq_1713	COG1706	bacterial-type flagellum-dependent cell motility
aq_1714	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
aq_1716	COG1028	Short-chain dehydrogenase reductase Sdr
aq_1717	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
aq_1717a	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
aq_1718	COG0424	maF-like protein
aq_1719	COG2703	oxygen carrier activity
aq_172	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
aq_1720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
aq_1723	COG0585	pseudouridine synthase activity
aq_1725	COG0481	GTPase activity
aq_1727	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
aq_1730	COG0072	phenylalanine-tRNA ligase activity
aq_1730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
aq_1730a	COG0425	Belongs to the sulfur carrier protein TusA family
aq_1731	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
aq_1732	COG3599	regulation of cell shape
aq_1732	COG1418	mRNA catabolic process
aq_1735	COG0484	heat shock protein binding
aq_1737	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
aq_1739	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
aq_1742	COG0463	Glycosyl transferase, family 2
aq_1744	COG0406	alpha-ribazole phosphatase activity
aq_1747	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
aq_175	COG0706	membrane insertase activity
aq_1751	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
aq_1755	COG0287	Prephenate dehydrogenase
aq_1757	COG0811	peptide transport
aq_1758	COG0564	pseudouridine synthase activity
aq_175a	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
aq_1765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
aq_1767	COG0268	Binds directly to 16S ribosomal RNA
aq_1768	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
aq_1769	COG0277	FAD linked oxidase domain protein
aq_177	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
aq_1770	COG0495	leucyl-tRNA aminoacylation
aq_1772	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
aq_1773a	COG0211	Belongs to the bacterial ribosomal protein bL27 family
aq_1777	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
aq_1780	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
aq_1780	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
aq_1782	COG0039	L-malate dehydrogenase activity
aq_1787	COG0134	indole-3-glycerol-phosphate synthase activity
aq_1789	COG0728	peptidoglycan biosynthetic process
aq_179	COG0356	it plays a direct role in the translocation of protons across the membrane
aq_1790	COG1980	fructose-bisphosphate aldolase activity
aq_1794	COG1692	metallophosphoesterase
aq_1795	COG0457	Tetratricopeptide repeat
aq_1796	COG0741	lytic transglycosylase activity
aq_1799	COG2897	thiosulfate sulfurtransferase activity
aq_1800	COG3439	Domain of unknown function DUF302
aq_1803	COG0737	Belongs to the 5'-nucleotidase family
aq_1806	COG2010	Cytochrome c
aq_1807	COG3258	Cytochrome c
aq_181	COG0107	imidazoleglycerol-phosphate synthase activity
aq_1815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
aq_1816	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
aq_1818	COG0788	formyltetrahydrofolate deformylase activity
aq_1822	COG2018	Roadblock/LC7 domain
aq_1825	COG5002	protein histidine kinase activity
aq_1827	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
aq_1827a	COG3174	membrane
aq_1832	COG0049	tRNA binding
aq_1834	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
aq_1836	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
aq_1837	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
aq_1838	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
aq_1839	COG0848	biopolymer transport protein
aq_183a	COG1758	RNA polymerase activity
aq_1840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
aq_1840a	COG2608	mercury ion transmembrane transporter activity
aq_1844	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
aq_1845	COG0457	Tetratricopeptide repeat
aq_185	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
aq_185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
aq_1851	COG0440	acetolactate synthase activity
aq_1853	COG1994	Peptidase M50
aq_1854	COG2010	Cytochrome c
aq_1855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
aq_1856	COG0556	nucleotide-excision repair
aq_1857	COG0316	Belongs to the HesB IscA family
aq_1859	COG1749	Flagellar hook protein flgE
aq_186	COG1012	belongs to the aldehyde dehydrogenase family
aq_1860	COG1580	Controls the rotational direction of flagella during chemotaxis
aq_1863	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
aq_1866	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
aq_1869	COG1832	CoA-binding protein
aq_1870	COG0653	protein targeting
aq_1873	COG0745	RESPONSE REGULATOR receiver
aq_1875	COG0275	rRNA processing
aq_1877	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
aq_1878	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
aq_1879	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
aq_1882	COG0592	DNA-directed DNA polymerase activity
aq_1884	COG1611	Belongs to the LOG family
aq_1887	COG0037	tRNA processing
aq_1888	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
aq_1889	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
aq_1890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
aq_1893	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
aq_1898	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
aq_1899	COG0463	Glycosyl transferase, family 2
aq_1899b	COG5611	PilT protein domain protein
aq_1903	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
aq_1905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
aq_1907	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
aq_1908	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
aq_1908a	COG1923	regulation of RNA biosynthetic process
aq_1909	COG1547	Domain of unknown function (DUF309)
aq_1910	COG1078	dGTPase activity
aq_1916	COG3118	belongs to the thioredoxin family
aq_1917	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
aq_1919	COG1160	GTP binding
aq_192	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
aq_1920	COG1338	Plays a role in the flagellum-specific transport system
aq_1922	COG1465	3-dehydroquinate synthase
aq_1924	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
aq_1928	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
aq_1930a	COG0267	Belongs to the bacterial ribosomal protein bL33 family
aq_1931	COG0250	Participates in transcription elongation, termination and antitermination
aq_1933	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
aq_1935	COG0081	regulation of translation
aq_1936	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
aq_1937	COG0222	ribosome binding
aq_1939	COG0085	RNA polymerase activity
aq_1945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
aq_1952	COG0095	Lipoate-protein ligase
aq_1953	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
aq_1954	COG0335	large ribosomal subunit rRNA binding
aq_1955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
aq_1958	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
aq_196	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
aq_1960	COG0351	phosphomethylpyrimidine kinase
aq_1961	COG1684	flagellar biosynthetic protein fliR
aq_1962	COG1987	bacterial-type flagellum assembly
aq_1963	COG0138	bifunctional purine biosynthesis protein purh
aq_1964	COG0750	zinc metalloprotease
aq_1965	COG0432	Pfam Uncharacterised protein family UPF0047
aq_1967	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
aq_1968	COG0140	phosphoribosyl-ATP diphosphatase activity
aq_1968	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
aq_1969	COG0436	Aminotransferase
aq_1971	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
aq_1973	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
aq_1975	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
aq_1977	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
aq_1978	COG1917	Cupin 2, conserved barrel domain protein
aq_1979	COG0235	Class ii aldolase
aq_1982	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
aq_1983	COG0483	inositol monophosphate 1-phosphatase activity
aq_1985	COG0237	dephospho-CoA kinase activity
aq_1986	COG1434	Gram-negative-bacterium-type cell wall biogenesis
aq_1988	COG0811	peptide transport
aq_1990	COG0406	alpha-ribazole phosphatase activity
aq_1991	COG0501	Belongs to the peptidase M48B family
aq_1994	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
aq_1996	COG1058	Belongs to the CinA family
aq_1996	COG1546	Belongs to the CinA family
aq_1997	COG0412	Dienelactone hydrolase
aq_1998	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
aq_2001	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
aq_2007	COG0052	Belongs to the universal ribosomal protein uS2 family
aq_2009	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
aq_2014	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
aq_2015	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
aq_2018	COG0573	inorganic phosphate transmembrane transporter activity
aq_2019	COG0581	inorganic phosphate transmembrane transporter activity
aq_202	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
aq_2020	COG1416	DNA-binding transcription factor activity
aq_2021	COG0312	modulator of DNA gyrase
aq_2023	COG0517	IMP dehydrogenase activity
aq_2023	COG0516	GMP reductase activity
aq_2027	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
aq_2027	COG2199	diguanylate cyclase activity
aq_2028	COG0490	domain, Protein
aq_2030	COG0475	glutathione-regulated potassium exporter activity
aq_2032	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
aq_2035	COG0602	queuosine metabolic process
aq_2036	COG4478	integral membrane protein
aq_2038	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
aq_2041	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
aq_2042	COG0359	binds to the 23S rRNA
aq_2043	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
aq_2045	COG0285	dihydrofolate synthase activity
aq_2046	COG0557	exoribonuclease II activity
aq_2051	COG4786	Flagellar basal body rod
aq_2053	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
aq_2054	COG2911	Protein conserved in bacteria
aq_2057	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
aq_2059	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
aq_206	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
aq_2060	COG0084	hydrolase, TatD family'
aq_2066	COG0586	Pfam SNARE associated Golgi protein
aq_2068	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
aq_2069	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
aq_207	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
aq_2071	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
aq_2075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
aq_2076	COG0135	phosphoribosylanthranilate isomerase activity
aq_2077	COG0733	neurotransmitter:sodium symporter activity
aq_2080	COG0616	signal peptide processing
aq_2084	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
aq_2087	COG3431	PFAM Phosphate-starvation-inducible E
aq_209	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
aq_2090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
aq_2094	COG0436	Aminotransferase
aq_2095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
aq_2096	COG0655	NAD(P)H dehydrogenase (quinone) activity
aq_2099	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
aq_2101	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
aq_2102	COG2264	protein methyltransferase activity
aq_2108	COG2176	DNA-directed DNA polymerase activity
aq_2109	COG0113	porphobilinogen synthase activity
aq_211	COG1017	nitric oxide dioxygenase activity
aq_2110	COG0123	including yeast histone deacetylase and acetoin utilization protein
aq_2113	COG0739	heme binding
aq_2113	COG1196	nuclear chromosome segregation
aq_2113	COG0741	lytic transglycosylase activity
aq_2114	COG2050	protein possibly involved in aromatic compounds catabolism
aq_2114	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
aq_2115	COG0438	transferase activity, transferring glycosyl groups
aq_2117	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
aq_2118	COG2165	general secretion pathway protein
aq_2119	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
aq_212	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
aq_2122	COG4608	Belongs to the ABC transporter superfamily
aq_2124	COG0635	Involved in the biosynthesis of porphyrin-containing compound
aq_2126	COG0322	excinuclease ABC activity
aq_2129	COG0385	Bile acid
aq_213	COG0347	Belongs to the P(II) protein family
aq_2131	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
aq_2132	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
aq_2135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
aq_2137	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
aq_2139	COG2226	methyltransferase
aq_2141	COG0751	glycine-tRNA ligase activity
aq_2142	COG0574	Belongs to the PEP-utilizing enzyme family
aq_2142	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
aq_2144	COG4972	Pilus assembly protein
aq_2146	COG1331	Highly conserved protein containing a thioredoxin domain
aq_2147	COG2885	chlorophyll binding
aq_2147a	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
aq_215	COG2223	nitrite transmembrane transporter activity
aq_2150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
aq_2153	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
aq_2154	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
aq_2155	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
aq_2155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
aq_2157	COG2389	metal-binding protein
aq_2158	COG0617	tRNA 3'-terminal CCA addition
aq_2160	COG0444	Belongs to the ABC transporter superfamily
aq_2163	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
aq_2168	COG3746	phosphate-selective porin O and P
aq_217	COG0243	molybdopterin cofactor binding
aq_2170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
aq_2171	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
aq_2174	COG0776	regulation of translation
aq_2177	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
aq_2178	COG2022	thiamine diphosphate biosynthetic process
aq_2179	COG1309	transcriptional regulator
aq_2181	COG0314	molybdopterin synthase activity
aq_2183	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
aq_2186	COG0446	pyridine nucleotide-disulphide oxidoreductase
aq_2190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
aq_2191	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
aq_2191	COG1845	cytochrome c oxidase, subunit III
aq_2192	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
aq_2195	COG1968	undecaprenyl-diphosphatase activity
aq_2199	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
aq_220	COG0756	dUTP diphosphatase activity
aq_2200	COG0459	protein refolding
aq_2203	COG1381	Involved in DNA repair and RecF pathway recombination
aq_221	COG1185	polyribonucleotide nucleotidyltransferase activity
aq_226a	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
aq_230	COG2204	response regulator
aq_231	COG4191	Histidine kinase
aq_232	COG0446	pyridine nucleotide-disulphide oxidoreductase
aq_235	COG0446	pyridine nucleotide-disulphide oxidoreductase
aq_236	COG0519	Catalyzes the synthesis of GMP from XMP
aq_236	COG0518	GMP synthase (glutamine-hydrolyzing) activity
aq_238	COG2032	superoxide dismutase activity
aq_239	COG0302	gtp cyclohydrolase
aq_240	COG0714	Associated with various cellular activities
aq_242	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
aq_244	COG0473	3-isopropylmalate dehydrogenase activity
aq_245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
aq_247	COG0154	amidase activity
aq_250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
aq_251	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
aq_253	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
aq_254	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
aq_257	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
aq_259	COG0195	Participates in both transcription termination and antitermination
aq_260	COG0779	Required for maturation of 30S ribosomal subunits
aq_262	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
aq_263	COG0181	hydroxymethylbilane synthase activity
aq_264	COG0095	Lipoate-protein ligase
aq_265	COG3706	GGDEF domain
aq_268	COG1959	2 iron, 2 sulfur cluster binding
aq_269	COG0720	synthase
aq_270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
aq_271	COG4641	Protein conserved in bacteria
aq_273	COG0436	Aminotransferase
aq_274	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
aq_281	COG1309	transcriptional regulator
aq_282	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
aq_284	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
aq_287	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
aq_291	COG0606	chelatase, subunit chli
aq_293	COG3431	PFAM Phosphate-starvation-inducible E
aq_296	COG4591	ABC-type transport system involved in lipoprotein release permease component
aq_297	COG1136	(ABC) transporter
aq_298	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
aq_301	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
aq_305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
aq_308	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
aq_311	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
aq_313	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
aq_314	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
aq_316	COG5002	protein histidine kinase activity
aq_319	COG0745	RESPONSE REGULATOR receiver
aq_322	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
aq_323	COG0667	Aldo Keto reductase
aq_324	COG1475	DNA binding
aq_325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
aq_326	COG1519	Transferase
aq_334	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
aq_338	COG2226	methyltransferase
aq_341	COG5001	Diguanylate cyclase
aq_341	COG3706	GGDEF domain
aq_341	COG2203	Gaf domain
aq_341	COG4251	negative regulation of phosphorylation
aq_342	COG3956	TIGRFAM MazG family protein
aq_343	COG0003	Pfam Anion-transporting ATPase
aq_346	COG0193	aminoacyl-tRNA hydrolase activity
aq_350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
aq_350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
aq_351	COG0495	leucyl-tRNA aminoacylation
aq_355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
aq_356	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
aq_358	COG1199	ATP-dependent helicase activity
aq_359	COG0795	lipopolysaccharide-transporting ATPase activity
aq_360	COG0149	triose-phosphate isomerase activity
aq_363	COG1276	copper resistance
aq_364	COG0251	oxidation-reduction process
aq_365	COG0442	prolyl-tRNA aminoacylation
aq_367	COG5002	protein histidine kinase activity
aq_367	COG5001	Diguanylate cyclase
aq_369	COG1518	maintenance of DNA repeat elements
aq_371	COG1203	CRISPR-associated helicase, Cas3
aq_384	COG3337	CRISPR-associated protein (Cas_Cmr5)
aq_388a	COG0425	Belongs to the sulfur carrier protein TusA family
aq_389	COG2210	Belongs to the sulfur carrier protein TusA family
aq_395	COG0446	pyridine nucleotide-disulphide oxidoreductase
aq_402	COG0509	glycine decarboxylation via glycine cleavage system
aq_404	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
aq_407	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
aq_409	COG0540	Belongs to the ATCase OTCase family
aq_410	COG0505	Belongs to the CarA family
aq_411	COG0617	tRNA 3'-terminal CCA addition
aq_411	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
aq_411	COG0517	IMP dehydrogenase activity
aq_413	COG1137	ATPase activity
aq_415	COG0475	glutathione-regulated potassium exporter activity
aq_415	COG0569	domain protein
aq_416	COG0820	rRNA (adenine-C2-)-methyltransferase activity
aq_417	COG1136	(ABC) transporter
aq_421	COG0436	Aminotransferase
aq_422	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
aq_422	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
aq_425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
aq_428	COG1490	D-aminoacyl-tRNA deacylase activity
aq_429	COG2199	diguanylate cyclase activity
aq_429	COG2203	Gaf domain
aq_433	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
aq_434	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
aq_436	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
aq_445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
aq_447	COG1285	pathogenesis
aq_448	COG1993	acr, cog1993
aq_449	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
aq_450	COG1993	acr, cog1993
aq_453	COG1295	ribonuclease BN
aq_454	COG1509	lysine 2,3-aminomutase activity
aq_458	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
aq_461	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
aq_473	COG3063	Type IV pilus biogenesis stability protein PilW
aq_474	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
aq_476	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
aq_478	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
aq_479	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
aq_481	COG0601	transmembrane transport
aq_484	COG0148	phosphopyruvate hydratase activity
aq_488	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
aq_490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
aq_495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
aq_496	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
aq_497	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
aq_498	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
aq_499	COG1475	DNA binding
aq_500	COG0492	ferredoxin-NADP+ reductase activity
aq_507	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
aq_510	COG2813	Specifically methylates the guanine in position
aq_511	COG0812	UDP-N-acetylmuramate dehydrogenase activity
aq_512	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
aq_516	COG0438	transferase activity, transferring glycosyl groups
aq_518	COG1091	dTDP-4-dehydrorhamnose reductase activity
aq_520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
aq_521	COG1181	Belongs to the D-alanine--D-alanine ligase family
aq_525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
aq_527	COG0315	cyclic pyranopterin monophosphate synthase activity
aq_528	COG0163	prenyltransferase activity
aq_533	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
aq_539	COG0795	lipopolysaccharide-transporting ATPase activity
aq_540	COG2095	MarC family integral membrane protein
aq_542	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
aq_544	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
aq_547	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
aq_548	COG1515	deoxyribonuclease V activity
aq_549	COG0512	Glutamine amidotransferase of anthranilate synthase
aq_551	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
aq_551	COG0649	NAD binding
aq_552	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
aq_553	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
aq_554	COG1187	pseudouridine synthase activity
aq_556	COG0768	penicillin binding
aq_557	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
aq_558	COG0352	thiamine-phosphate diphosphorylase activity
aq_561	COG0497	DNA recombination
aq_563	COG3706	GGDEF domain
aq_565	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
aq_568	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
aq_573	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
aq_574	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
aq_576	COG2815	serine threonine protein kinase
aq_576	COG0515	serine threonine protein kinase
aq_579	COG0242	peptide deformylase activity
aq_582	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
aq_587	COG0402	S-adenosylhomocysteine deaminase activity
aq_589	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
aq_589	COG0662	Cupin 2, conserved barrel domain protein
aq_591	COG1547	Domain of unknown function (DUF309)
aq_594	COG1053	succinate dehydrogenase
aq_597	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
aq_604	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
aq_607	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
aq_608	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
aq_609	COG0012	GTP binding
aq_618	COG0693	protein deglycase activity
aq_620	COG1121	(ABC) transporter
aq_624	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
aq_626	COG0156	8-amino-7-oxononanoate synthase activity
aq_628	COG2067	long-chain fatty acid transport protein
aq_628a	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
aq_629	COG1196	nuclear chromosome segregation
aq_632	COG1242	4 iron, 4 sulfur cluster binding
aq_633	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
aq_638	COG0583	DNA-binding transcription factor activity
aq_640	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
aq_642	COG0430	RNA-3'-phosphate cyclase activity
aq_648	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
aq_651	COG0009	L-threonylcarbamoyladenylate synthase
aq_652	COG4942	peptidase
aq_653	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
aq_657	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
aq_660	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
aq_667	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
aq_672	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
aq_673	COG0355	proton-transporting ATP synthase activity, rotational mechanism
aq_674	COG2813	Specifically methylates the guanine in position
aq_676	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
aq_679	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
aq_682	COG0003	Pfam Anion-transporting ATPase
aq_684	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
aq_685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
aq_686	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
aq_691	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
aq_692	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
aq_693	COG3746	phosphate-selective porin O and P
aq_698	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
aq_701	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
aq_702	COG0789	Transcriptional regulator
aq_703	COG0484	heat shock protein binding
aq_705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
aq_706	COG0133	tryptophan synthase activity
aq_707	COG2022	thiamine diphosphate biosynthetic process
aq_707	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
aq_711	COG2976	Protein conserved in bacteria
aq_712	COG0233	cytoplasmic translational termination
aq_713	COG0528	UMP kinase activity
aq_715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
aq_717	COG0058	SHG alpha-glucan phosphorylase activity
aq_718	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
aq_721	COG0297	glycogen (starch) synthase activity
aq_722	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
aq_723	COG1640	4-alpha-glucanotransferase
aq_724	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
aq_727	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
aq_731	COG0785	Cytochrome C biogenesis protein
aq_732	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
aq_734	COG0049	tRNA binding
aq_735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
aq_736	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
aq_737	COG0489	protein tyrosine kinase activity
aq_739	COG1104	cysteine desulfurase activity
aq_740	COG0628	permease
aq_742	COG0151	Belongs to the GarS family
aq_748	COG0142	geranyltranstransferase activity
aq_749	COG0101	tRNA pseudouridine synthase activity
aq_750	COG2222	sugar isomerase
aq_755	COG1332	CRISPR-associated RAMP protein, Csm5 family
aq_756	COG1851	Uncharacterised protein family (UPF0128)
aq_759	COG1730	sister chromatid segregation
aq_761	COG0445	tRNA wobble uridine modification
aq_763	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
aq_765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
aq_768	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
aq_769	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
aq_775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
aq_777	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
aq_778	COG0391	Required for morphogenesis under gluconeogenic growth conditions
aq_782	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
aq_786	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
aq_789	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
aq_792a	COG0291	Belongs to the bacterial ribosomal protein bL35 family
aq_793	COG0210	DNA helicase
aq_797	COG0793	Belongs to the peptidase S41A family
aq_801	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
aq_806	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
aq_812	COG0668	transmembrane transport
aq_813	COG0736	holo-[acyl-carrier-protein] synthase activity
aq_815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
aq_816	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
aq_819	COG0815	Transfers the fatty acyl group on membrane lipoproteins
aq_821	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
aq_831	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
aq_832	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
aq_833	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
aq_835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
aq_837	COG0129	dihydroxy-acid dehydratase activity
aq_841	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
aq_843	COG0802	atpase or kinase
aq_844	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
aq_845	COG1077	Cell shape determining protein MreB Mrl
aq_849	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
aq_851	COG0598	Magnesium transport protein CorA
aq_852	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
aq_855	COG0589	response to stress
aq_857	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
aq_858	COG0450	alkyl hydroperoxide reductase
aq_863	COG3002	Belongs to the UPF0753 family
aq_866	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
aq_867a	COG0828	Belongs to the bacterial ribosomal protein bS21 family
aq_869	COG0157	Belongs to the NadC ModD family
aq_871	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
aq_873	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
aq_876	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
aq_877	COG2894	cell division
aq_878	COG0850	regulation of cytokinetic process
aq_880	COG1458	PINc domain ribonuclease
aq_881	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
aq_886	COG1110	DNA topoisomerase II activity
aq_890	COG1355	regulation of microtubule-based process
aq_892	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
aq_894	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
aq_895	COG0142	geranyltranstransferase activity
aq_896	COG0822	iron-sulfur transferase activity
aq_901	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
aq_903	COG0590	tRNA wobble adenosine to inosine editing
aq_905	COG5000	phosphorelay sensor kinase activity
aq_906	COG0704	Plays a role in the regulation of phosphate uptake
aq_908	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
aq_909	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
aq_910	COG1484	DNA-dependent DNA replication
aq_915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
aq_916	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
aq_919a	COG0633	Ferredoxin
aq_920	COG0552	protein localization to endoplasmic reticulum
aq_920	COG0457	Tetratricopeptide repeat
aq_923	COG0018	arginyl-trna synthetase
aq_924	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
aq_928	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
aq_929	COG0475	glutathione-regulated potassium exporter activity
aq_931	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
aq_932	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
aq_936	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
aq_940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
aq_944	COG0509	glycine decarboxylation via glycine cleavage system
aq_945	COG0752	glycyl-tRNA synthetase alpha subunit
aq_946	COG0571	ribonuclease III activity
aq_948	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
aq_951	COG0077	Prephenate dehydratase
aq_951	COG1605	Chorismate mutase
aq_952	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
aq_953	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
aq_955	COG0681	Belongs to the peptidase S26 family
aq_957	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
aq_958	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
aq_959	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
aq_959	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
aq_960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
aq_967	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
aq_968	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
aq_969	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
aq_970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
aq_973	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
aq_975	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
aq_979	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
aq_980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
aq_983	COG1957	nucleoside hydrolase
aq_987	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
aq_988	COG1999	signal sequence binding
aq_992	COG0180	Tryptophanyl-tRNA synthetase
aq_996	COG0443	Heat shock 70 kDa protein
aq_999	COG0318	PFAM AMP-dependent synthetase and ligase
aq_t20	COG0544	peptidyl-prolyl cis-trans isomerase activity
aq_t21	COG0544	peptidyl-prolyl cis-trans isomerase activity