locus-tag	class	description
D1815_RS00005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1815_RS00015	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1815_RS00025	COG2860	membrane
D1815_RS00030	COG0492	ferredoxin-NADP+ reductase activity
D1815_RS00110	COG0714	Associated with various cellular activities
D1815_RS00140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1815_RS00165	COG3279	Response regulator of the LytR AlgR family
D1815_RS00170	COG0402	S-adenosylhomocysteine deaminase activity
D1815_RS00200	COG3275	phosphorelay sensor kinase activity
D1815_RS00230	COG1252	NADH dehydrogenase
D1815_RS00290	COG1595	DNA-templated transcription, initiation
D1815_RS00340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS00375	COG1335	isochorismatase
D1815_RS00395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1815_RS00440	COG2205	protein histidine kinase activity
D1815_RS00440	COG3437	response regulator, receiver
D1815_RS00440	COG3850	Histidine kinase
D1815_RS00440	COG4999	Histidine kinase
D1815_RS00445	COG2198	Histidine kinase
D1815_RS00445	COG5002	protein histidine kinase activity
D1815_RS00445	COG0784	Response regulator, receiver
D1815_RS00480	COG0488	(ABC) transporter
D1815_RS00520	COG2819	hydrolase of the alpha beta superfamily
D1815_RS00580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1815_RS00580	COG2207	Transcriptional regulator
D1815_RS00700	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D1815_RS00705	COG3387	PFAM Glycoside hydrolase 15-related
D1815_RS00725	COG1960	acyl-CoA dehydrogenase activity
D1815_RS00730	COG0183	Belongs to the thiolase family
D1815_RS00735	COG1024	Enoyl-CoA hydratase
D1815_RS00735	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1815_RS00740	COG1846	Transcriptional regulator
D1815_RS00745	COG1022	Amp-dependent synthetase and ligase
D1815_RS00765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1815_RS00765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1815_RS00790	COG1132	(ABC) transporter
D1815_RS00795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1815_RS00800	COG0463	Glycosyl transferase, family 2
D1815_RS00825	COG0254	rRNA binding
D1815_RS00845	COG4166	transmembrane transport
D1815_RS00850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1815_RS00865	COG0741	lytic transglycosylase activity
D1815_RS00870	COG0730	response to heat
D1815_RS00890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1815_RS00895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1815_RS00910	COG2192	nodulation
D1815_RS00920	COG0529	Catalyzes the synthesis of activated sulfate
D1815_RS00950	COG1132	(ABC) transporter
D1815_RS01015	COG0800	Aldolase
D1815_RS01030	COG2271	Major facilitator Superfamily
D1815_RS01055	COG0702	epimerase
D1815_RS01060	COG4771	TonB-dependent receptor
D1815_RS01065	COG2186	Transcriptional regulator
D1815_RS01075	COG0137	argininosuccinate synthase activity
D1815_RS01080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1815_RS01085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1815_RS01090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1815_RS01100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1815_RS01110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1815_RS01120	COG0165	Argininosuccinate lyase
D1815_RS01140	COG0673	inositol 2-dehydrogenase activity
D1815_RS01145	COG2211	Major facilitator Superfamily
D1815_RS01175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1815_RS01180	COG0439	Biotin carboxylase
D1815_RS01185	COG4770	biotin carboxylase activity
D1815_RS01210	COG2201	protein-glutamate methylesterase activity
D1815_RS01215	COG2201	protein-glutamate methylesterase activity
D1815_RS01220	COG3279	Response regulator of the LytR AlgR family
D1815_RS01225	COG2201	protein-glutamate methylesterase activity
D1815_RS01235	COG4251	negative regulation of phosphorylation
D1815_RS01255	COG1573	uracil-dna glycosylase
D1815_RS01265	COG0312	modulator of DNA gyrase
D1815_RS01275	COG0714	Associated with various cellular activities
D1815_RS01365	COG1522	sequence-specific DNA binding
D1815_RS01395	COG1063	alcohol dehydrogenase
D1815_RS01420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS01440	COG3118	belongs to the thioredoxin family
D1815_RS01515	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS01530	COG1942	4-Oxalocrotonate Tautomerase
D1815_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS01565	COG1362	aminopeptidase activity
D1815_RS01575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1815_RS01590	COG1404	Belongs to the peptidase S8 family
D1815_RS01600	COG0577	efflux transmembrane transporter activity
D1815_RS01600	COG1136	(ABC) transporter
D1815_RS01630	COG0577	efflux transmembrane transporter activity
D1815_RS01635	COG0577	efflux transmembrane transporter activity
D1815_RS01640	COG0577	efflux transmembrane transporter activity
D1815_RS01640	COG1136	(ABC) transporter
D1815_RS01645	COG0577	efflux transmembrane transporter activity
D1815_RS01650	COG1136	(ABC) transporter
D1815_RS01675	COG3608	succinylglutamate desuccinylase aspartoacylase
D1815_RS01695	COG1131	(ABC) transporter
D1815_RS01700	COG0523	cobalamin synthesis protein
D1815_RS01705	COG1506	peptidase
D1815_RS01710	COG0302	gtp cyclohydrolase
D1815_RS01720	COG1136	(ABC) transporter
D1815_RS01735	COG0737	Belongs to the 5'-nucleotidase family
D1815_RS01740	COG0737	Belongs to the 5'-nucleotidase family
D1815_RS01745	COG0523	cobalamin synthesis protein
D1815_RS01785	COG1404	Belongs to the peptidase S8 family
D1815_RS01805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D1815_RS01820	COG0004	ammonium transporteR
D1815_RS01825	COG0347	Belongs to the P(II) protein family
D1815_RS01830	COG0070	glutamate synthase
D1815_RS01830	COG0069	glutamate synthase activity
D1815_RS01830	COG0067	glutamate synthase
D1815_RS01840	COG3279	Response regulator of the LytR AlgR family
D1815_RS01845	COG3275	phosphorelay sensor kinase activity
D1815_RS01855	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D1815_RS01880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1815_RS01885	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1815_RS01905	COG1595	DNA-templated transcription, initiation
D1815_RS01910	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1815_RS01985	COG3250	beta-galactosidase activity
D1815_RS02000	COG2890	protein-(glutamine-N5) methyltransferase activity
D1815_RS02020	COG0702	epimerase
D1815_RS02065	COG0657	acetylesterase activity
D1815_RS02090	COG0823	Involved in the tonB-independent uptake of proteins
D1815_RS02090	COG1506	peptidase
D1815_RS02170	COG0563	adenylate kinase activity
D1815_RS02280	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1815_RS02500	COG3104	oligopeptide transport
D1815_RS02545	COG4974	Belongs to the 'phage' integrase family
D1815_RS02555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1815_RS02600	COG0069	glutamate synthase activity
D1815_RS02605	COG1473	amidohydrolase
D1815_RS02630	COG0366	Alpha amylase catalytic
D1815_RS02635	COG0366	Alpha amylase catalytic
D1815_RS02675	COG2197	response regulator
D1815_RS02680	COG4585	Histidine kinase
D1815_RS02685	COG1271	oxidase subunit
D1815_RS02755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1815_RS02760	COG0735	belongs to the Fur family
D1815_RS02765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1815_RS02770	COG0501	Belongs to the peptidase M48B family
D1815_RS02775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1815_RS02780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1815_RS02785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1815_RS02790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1815_RS02795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1815_RS02845	COG0784	Response regulator, receiver
D1815_RS02845	COG5002	protein histidine kinase activity
D1815_RS02845	COG2198	Histidine kinase
D1815_RS02910	COG4104	PAAR repeat-containing protein
D1815_RS02910	COG3209	COG3209 Rhs family protein
D1815_RS02935	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1815_RS02980	COG1595	DNA-templated transcription, initiation
D1815_RS02990	COG0335	large ribosomal subunit rRNA binding
D1815_RS02995	COG0336	Belongs to the RNA methyltransferase TrmD family
D1815_RS03015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1815_RS03025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1815_RS03035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1815_RS03040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1815_RS03045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1815_RS03055	COG1739	Uncharacterized protein family UPF0029
D1815_RS03065	COG1011	Hydrolase
D1815_RS03070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1815_RS03070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1815_RS03085	COG2890	protein-(glutamine-N5) methyltransferase activity
D1815_RS03095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1815_RS03125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1815_RS03155	COG0497	DNA recombination
D1815_RS03160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1815_RS03165	COG0463	Glycosyl transferase, family 2
D1815_RS03165	COG1216	Glycosyl transferase, family 2
D1815_RS03175	COG0237	dephospho-CoA kinase activity
D1815_RS03190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1815_RS03195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1815_RS03205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1815_RS03220	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1815_RS03225	COG0673	inositol 2-dehydrogenase activity
D1815_RS03235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1815_RS03245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1815_RS03270	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1815_RS03285	COG2356	endonuclease I
D1815_RS03295	COG0542	response to heat
D1815_RS03305	COG2346	COG2346, Truncated hemoglobins
D1815_RS03330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1815_RS03365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1815_RS03375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS03395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1815_RS03400	COG3279	Response regulator of the LytR AlgR family
D1815_RS03425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1815_RS03435	COG1132	(ABC) transporter
D1815_RS03445	COG1988	membrane-bound metal-dependent
D1815_RS03455	COG0513	Belongs to the DEAD box helicase family
D1815_RS03460	COG0009	L-threonylcarbamoyladenylate synthase
D1815_RS03475	COG3279	Response regulator of the LytR AlgR family
D1815_RS03480	COG3275	phosphorelay sensor kinase activity
D1815_RS03485	COG0366	Alpha amylase catalytic
D1815_RS03535	COG0626	cystathionine gamma-synthase activity
D1815_RS03590	COG1393	Belongs to the ArsC family
D1815_RS03610	COG3422	double-strand break repair
D1815_RS03620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1815_RS03625	COG1770	oligopeptidase
D1815_RS03635	COG0156	8-amino-7-oxononanoate synthase activity
D1815_RS03650	COG0702	epimerase
D1815_RS03655	COG4771	TonB-dependent receptor
D1815_RS03660	COG2186	Transcriptional regulator
D1815_RS03710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1815_RS03720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1815_RS03725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1815_RS03760	COG1501	Belongs to the glycosyl hydrolase 31 family
D1815_RS03765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1815_RS03775	COG3708	Transcriptional regulator
D1815_RS03775	COG2207	Transcriptional regulator
D1815_RS03835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1815_RS03845	COG0513	Belongs to the DEAD box helicase family
D1815_RS03865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D1815_RS03895	COG1136	(ABC) transporter
D1815_RS03905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1815_RS03910	COG0302	gtp cyclohydrolase
D1815_RS03935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1815_RS03940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1815_RS03950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1815_RS03970	COG4771	TonB-dependent receptor
D1815_RS03975	COG4771	TonB-dependent receptor
D1815_RS03995	COG0012	GTP binding
D1815_RS04005	COG2205	protein histidine kinase activity
D1815_RS04005	COG2198	Histidine kinase
D1815_RS04005	COG0784	Response regulator, receiver
D1815_RS04015	COG2267	carboxylic ester hydrolase activity
D1815_RS04040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D1815_RS04065	COG2824	Alkylphosphonate utilization operon protein PhnA
D1815_RS04070	COG0861	Integral membrane protein TerC family
D1815_RS04090	COG1522	sequence-specific DNA binding
D1815_RS04095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1815_RS04120	COG0793	Belongs to the peptidase S41A family
D1815_RS04160	COG1169	isochorismate synthase
D1815_RS04165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D1815_RS04175	COG2996	Protein conserved in bacteria
D1815_RS04200	COG0022	dehydrogenase e1 component
D1815_RS04220	COG1611	Belongs to the LOG family
D1815_RS04225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1815_RS04235	COG0471	metal ion transport
D1815_RS04245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1815_RS04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1815_RS04275	COG3813	Protein conserved in bacteria
D1815_RS04285	COG0686	Belongs to the AlaDH PNT family
D1815_RS04300	COG2204	response regulator
D1815_RS04305	COG1078	dGTPase activity
D1815_RS04310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1815_RS04315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1815_RS04315	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D1815_RS04320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1815_RS04325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1815_RS04340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D1815_RS04345	COG0612	Peptidase, M16
D1815_RS04360	COG4145	pantothenate transmembrane transporter activity
D1815_RS04375	COG1193	negative regulation of DNA recombination
D1815_RS04380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1815_RS04395	COG1054	Belongs to the UPF0176 family
D1815_RS04400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1815_RS04405	COG0813	purine-nucleoside phosphorylase activity
D1815_RS04425	COG0022	dehydrogenase e1 component
D1815_RS04430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1815_RS04435	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1815_RS04460	COG0438	transferase activity, transferring glycosyl groups
D1815_RS04465	COG0438	transferase activity, transferring glycosyl groups
D1815_RS04485	COG0438	transferase activity, transferring glycosyl groups
D1815_RS04495	COG1696	Membrane protein involved in D-alanine export
D1815_RS04505	COG5434	Belongs to the glycosyl hydrolase 28 family
D1815_RS04520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1815_RS04540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1815_RS04545	COG1045	serine acetyltransferase
D1815_RS04570	COG1696	Membrane protein involved in D-alanine export
D1815_RS04575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1815_RS04580	COG1086	Polysaccharide biosynthesis protein
D1815_RS04615	COG1595	DNA-templated transcription, initiation
D1815_RS04620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1815_RS04625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1815_RS04660	COG2198	Histidine kinase
D1815_RS04660	COG0784	Response regulator, receiver
D1815_RS04660	COG5002	protein histidine kinase activity
D1815_RS04670	COG1595	DNA-templated transcription, initiation
D1815_RS04750	COG0545	Peptidyl-prolyl cis-trans isomerase
D1815_RS04755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1815_RS04760	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D1815_RS04795	COG3279	Response regulator of the LytR AlgR family
D1815_RS04800	COG2972	Histidine kinase
D1815_RS04885	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D1815_RS04910	COG1131	(ABC) transporter
D1815_RS04915	COG3275	phosphorelay sensor kinase activity
D1815_RS04920	COG3279	Response regulator of the LytR AlgR family
D1815_RS04925	COG3279	Response regulator of the LytR AlgR family
D1815_RS04930	COG3275	phosphorelay sensor kinase activity
D1815_RS04935	COG1131	(ABC) transporter
D1815_RS04945	COG3693	PFAM glycoside hydrolase, family 10
D1815_RS04965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS04975	COG1595	DNA-templated transcription, initiation
D1815_RS04985	COG1979	alcohol dehydrogenase
D1815_RS04990	COG0784	Response regulator, receiver
D1815_RS04990	COG2198	Histidine kinase
D1815_RS04990	COG5002	protein histidine kinase activity
D1815_RS05060	COG3279	Response regulator of the LytR AlgR family
D1815_RS05080	COG1595	DNA-templated transcription, initiation
D1815_RS05160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1815_RS05195	COG3275	phosphorelay sensor kinase activity
D1815_RS05200	COG3279	Response regulator of the LytR AlgR family
D1815_RS05210	COG0243	molybdopterin cofactor binding
D1815_RS05225	COG0437	4 iron, 4 sulfur cluster binding
D1815_RS05240	COG1794	racemase activity, acting on amino acids and derivatives
D1815_RS05275	COG4181	ATPase activity
D1815_RS05340	COG0604	alcohol dehydrogenase
D1815_RS05340	COG3321	synthase
D1815_RS05390	COG2205	protein histidine kinase activity
D1815_RS05390	COG3292	Two component regulator propeller
D1815_RS05390	COG0745	RESPONSE REGULATOR receiver
D1815_RS05425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS05430	COG3275	phosphorelay sensor kinase activity
D1815_RS05435	COG3279	Response regulator of the LytR AlgR family
D1815_RS05470	COG1024	Enoyl-CoA hydratase
D1815_RS05480	COG2207	Transcriptional regulator
D1815_RS05495	COG1309	transcriptional regulator
D1815_RS05505	COG1917	Cupin 2, conserved barrel domain protein
D1815_RS05505	COG4977	sequence-specific DNA binding
D1815_RS05540	COG2814	Major facilitator Superfamily
D1815_RS05560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1815_RS05570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1815_RS05595	COG2885	chlorophyll binding
D1815_RS05605	COG2885	chlorophyll binding
D1815_RS05615	COG2270	Major facilitator Superfamily
D1815_RS05630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1815_RS05635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1815_RS05640	COG0297	glycogen (starch) synthase activity
D1815_RS05655	COG2378	regulation of single-species biofilm formation
D1815_RS05665	COG1741	Belongs to the pirin family
D1815_RS05685	COG0641	radical SAM
D1815_RS05745	COG0659	secondary active sulfate transmembrane transporter activity
D1815_RS05755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1815_RS05770	COG1187	pseudouridine synthase activity
D1815_RS05800	COG0488	(ABC) transporter
D1815_RS05815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1815_RS05855	COG1629	transport
D1815_RS05855	COG4206	TonB-dependent receptor
D1815_RS05860	COG2304	oxidoreductase activity
D1815_RS05875	COG4948	Mandelate Racemase Muconate Lactonizing
D1815_RS05880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1815_RS05885	COG1575	Belongs to the MenA family. Type 1 subfamily
D1815_RS05895	COG0366	Alpha amylase catalytic
D1815_RS05920	COG0668	transmembrane transport
D1815_RS05940	COG1480	7TM receptor with intracellular HD hydrolase
D1815_RS05945	COG0183	Belongs to the thiolase family
D1815_RS05950	COG0791	NLP P60 protein
D1815_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS05975	COG3279	Response regulator of the LytR AlgR family
D1815_RS05980	COG3275	phosphorelay sensor kinase activity
D1815_RS05990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1815_RS06005	COG1045	serine acetyltransferase
D1815_RS06020	COG0514	ATP-dependent DNA helicase (RecQ)
D1815_RS06030	COG2072	flavoprotein involved in K transport
D1815_RS06035	COG2258	MOSC domain
D1815_RS06045	COG2823	Periplasmic or secreted lipoprotein
D1815_RS06045	COG1652	LysM domain
D1815_RS06060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1815_RS06075	COG0640	Transcriptional regulator
D1815_RS06105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1815_RS06110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1815_RS06120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1815_RS06155	COG4974	Belongs to the 'phage' integrase family
D1815_RS06175	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1815_RS06180	COG0527	aspartate kinase activity
D1815_RS06180	COG0460	homoserine dehydrogenase
D1815_RS06185	COG0083	homoserine kinase activity
D1815_RS06190	COG0251	oxidation-reduction process
D1815_RS06195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1815_RS06215	COG0445	tRNA wobble uridine modification
D1815_RS06240	COG3279	Response regulator of the LytR AlgR family
D1815_RS06265	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1815_RS06270	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1815_RS06320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1815_RS06325	COG0732	type I restriction modification DNA specificity domain
D1815_RS06350	COG2827	Endonuclease containing a URI domain
D1815_RS06385	COG3179	chitinase
D1815_RS06425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1815_RS06435	COG3011	Protein conserved in bacteria
D1815_RS06445	COG0076	glutamate decarboxylase activity
D1815_RS06450	COG1301	dicarboxylic acid transport
D1815_RS06455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1815_RS06460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1815_RS06505	COG2610	gluconate transmembrane transporter activity
D1815_RS06530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS06540	COG0277	FAD linked oxidase domain protein
D1815_RS06540	COG0247	lactate metabolic process
D1815_RS06565	COG0438	transferase activity, transferring glycosyl groups
D1815_RS06635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1815_RS06650	COG0259	pyridoxamine-phosphate oxidase activity
D1815_RS06655	COG1234	tRNA 3'-trailer cleavage
D1815_RS06660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1815_RS06670	COG0540	Belongs to the ATCase OTCase family
D1815_RS06675	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1815_RS06705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1815_RS06705	COG0140	phosphoribosyl-ATP diphosphatase activity
D1815_RS06710	COG0107	imidazoleglycerol-phosphate synthase activity
D1815_RS06720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1815_RS06730	COG0131	Imidazoleglycerol-phosphate dehydratase
D1815_RS06735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1815_RS06745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1815_RS06750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1815_RS06770	COG2205	protein histidine kinase activity
D1815_RS06770	COG0784	Response regulator, receiver
D1815_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS06805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1815_RS06825	COG0415	Belongs to the DNA photolyase family
D1815_RS06840	COG0583	DNA-binding transcription factor activity
D1815_RS06845	COG2986	histidine ammonia-lyase
D1815_RS06855	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1815_RS06860	COG0010	Belongs to the arginase family
D1815_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS06900	COG0604	alcohol dehydrogenase
D1815_RS06905	COG2130	NADP-dependent
D1815_RS06910	COG1024	Enoyl-CoA hydratase
D1815_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS06935	COG1960	acyl-CoA dehydrogenase activity
D1815_RS06940	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS06945	COG1960	acyl-CoA dehydrogenase activity
D1815_RS06960	COG0745	RESPONSE REGULATOR receiver
D1815_RS06965	COG0513	Belongs to the DEAD box helicase family
D1815_RS06970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1815_RS06990	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1815_RS07010	COG0514	ATP-dependent DNA helicase (RecQ)
D1815_RS07015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1815_RS07025	COG1678	Uncharacterized ACR, COG1678
D1815_RS07030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1815_RS07050	COG0124	histidyl-tRNA synthetase
D1815_RS07055	COG0577	efflux transmembrane transporter activity
D1815_RS07070	COG0359	binds to the 23S rRNA
D1815_RS07075	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1815_RS07080	COG0360	Binds together with S18 to 16S ribosomal RNA
D1815_RS07085	COG3279	Response regulator of the LytR AlgR family
D1815_RS07090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1815_RS07115	COG1295	ribonuclease BN
D1815_RS07125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1815_RS07175	COG0424	maF-like protein
D1815_RS07185	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1815_RS07190	COG0217	transcriptional regulatory protein
D1815_RS07205	COG1454	alcohol dehydrogenase
D1815_RS07215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1815_RS07245	COG4989	oxidoreductase activity
D1815_RS07250	COG1472	Belongs to the glycosyl hydrolase 3 family
D1815_RS07260	COG0247	lactate metabolic process
D1815_RS07260	COG2181	nitrate reductase activity
D1815_RS07270	COG0247	lactate metabolic process
D1815_RS07270	COG2181	nitrate reductase activity
D1815_RS07275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1815_RS07280	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1815_RS07285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1815_RS07290	COG0251	oxidation-reduction process
D1815_RS07305	COG0205	6-phosphofructokinase activity
D1815_RS07315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1815_RS07370	COG0628	permease
D1815_RS07415	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1815_RS07445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1815_RS07460	COG0726	polysaccharide deacetylase
D1815_RS07475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1815_RS07485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1815_RS07500	COG1131	(ABC) transporter
D1815_RS07520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1815_RS07535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1815_RS07540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1815_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS07555	COG2986	histidine ammonia-lyase
D1815_RS07620	COG0702	epimerase
D1815_RS07625	COG4771	TonB-dependent receptor
D1815_RS07635	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1815_RS07640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1815_RS07640	COG1333	cytochrome c biogenesis protein
D1815_RS07650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D1815_RS07655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1815_RS07665	COG1757	Na H antiporter
D1815_RS07670	COG1607	acyl-coa hydrolase
D1815_RS07675	COG0778	Nitroreductase
D1815_RS07685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1815_RS07690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1815_RS07690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1815_RS07705	COG1674	ftsk spoiiie
D1815_RS07710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D1815_RS07715	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D1815_RS07730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1815_RS07735	COG0450	alkyl hydroperoxide reductase
D1815_RS07745	COG0626	cystathionine gamma-synthase activity
D1815_RS07750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1815_RS07780	COG0415	Belongs to the DNA photolyase family
D1815_RS07785	COG3046	protein related to deoxyribodipyrimidine photolyase
D1815_RS07790	COG0415	Belongs to the DNA photolyase family
D1815_RS07810	COG0302	gtp cyclohydrolase
D1815_RS07845	COG1388	LysM domain
D1815_RS07845	COG0791	NLP P60 protein
D1815_RS07955	COG2205	protein histidine kinase activity
D1815_RS08015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1815_RS08020	COG0542	response to heat
D1815_RS08040	COG1418	mRNA catabolic process
D1815_RS08060	COG0739	heme binding
D1815_RS08075	COG1104	cysteine desulfurase activity
D1815_RS08115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1815_RS08155	COG0116	Belongs to the methyltransferase superfamily
D1815_RS08160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1815_RS08180	COG1272	protein, Hemolysin III
D1815_RS08185	COG0784	Response regulator, receiver
D1815_RS08185	COG2198	Histidine kinase
D1815_RS08185	COG5002	protein histidine kinase activity
D1815_RS08220	COG1363	Peptidase, m42
D1815_RS08225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1815_RS08230	COG0745	RESPONSE REGULATOR receiver
D1815_RS08235	COG5002	protein histidine kinase activity
D1815_RS08245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1815_RS08265	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1815_RS08270	COG0783	Belongs to the Dps family
D1815_RS08310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1815_RS08325	COG1560	Kdo2-lipid A biosynthetic process
D1815_RS08330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1815_RS08345	COG0405	Gamma-glutamyltransferase
D1815_RS08360	COG0443	Heat shock 70 kDa protein
D1815_RS08365	COG1760	l-serine dehydratase
D1815_RS08380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1815_RS08385	COG0564	pseudouridine synthase activity
D1815_RS08405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1815_RS08410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1815_RS08415	COG0066	3-isopropylmalate dehydratase activity
D1815_RS08420	COG0473	3-isopropylmalate dehydrogenase activity
D1815_RS08430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1815_RS08435	COG1702	phosphate starvation-inducible protein PhoH
D1815_RS08470	COG0592	DNA-directed DNA polymerase activity
D1815_RS08480	COG0693	protein deglycase activity
D1815_RS08490	COG2356	endonuclease I
D1815_RS08510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1815_RS08515	COG0857	belongs to the CobB CobQ family
D1815_RS08515	COG0280	phosphate acetyltransferase
D1815_RS08585	COG0488	(ABC) transporter
D1815_RS08595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1815_RS08600	COG0300	oxidoreductase activity
D1815_RS08640	COG2885	chlorophyll binding
D1815_RS08675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1815_RS08720	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
D1815_RS08725	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1815_RS08735	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1815_RS08755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1815_RS08760	COG1120	ATPase activity
D1815_RS08800	COG1607	acyl-coa hydrolase
D1815_RS08810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1815_RS08815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1815_RS08825	COG0028	Belongs to the TPP enzyme family
D1815_RS08830	COG0129	dihydroxy-acid dehydratase activity
D1815_RS08835	COG2197	response regulator
D1815_RS08860	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1815_RS08870	COG1914	H( )-stimulated, divalent metal cation uptake system
D1815_RS08880	COG1222	aaa ATPase
D1815_RS08950	COG3501	Rhs element vgr protein
D1815_RS08995	COG0612	Peptidase, M16
D1815_RS09005	COG0606	chelatase, subunit chli
D1815_RS09010	COG0527	aspartate kinase activity
D1815_RS09020	COG3590	peptidase
D1815_RS09045	COG0303	'Molybdopterin
D1815_RS09055	COG0746	molybdenum cofactor guanylyltransferase activity
D1815_RS09065	COG0314	molybdopterin synthase activity
D1815_RS09070	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1815_RS09070	COG0315	cyclic pyranopterin monophosphate synthase activity
D1815_RS09080	COG0784	Response regulator, receiver
D1815_RS09080	COG2198	Histidine kinase
D1815_RS09080	COG5002	protein histidine kinase activity
D1815_RS09115	COG0243	molybdopterin cofactor binding
D1815_RS09150	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1815_RS09150	COG1333	cytochrome c biogenesis protein
D1815_RS09155	COG1333	cytochrome c biogenesis protein
D1815_RS09155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1815_RS09170	COG1116	anion transmembrane transporter activity
D1815_RS09175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1815_RS09175	COG1116	anion transmembrane transporter activity
D1815_RS09180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1815_RS09185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1815_RS09190	COG2223	nitrite transmembrane transporter activity
D1815_RS09210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1815_RS09225	COG4585	Histidine kinase
D1815_RS09245	COG0205	6-phosphofructokinase activity
D1815_RS09260	COG0366	Alpha amylase catalytic
D1815_RS09265	COG0366	Alpha amylase catalytic
D1815_RS09270	COG1554	hydrolase, family 65, central catalytic
D1815_RS09275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1815_RS09290	COG4206	TonB-dependent receptor
D1815_RS09290	COG1629	transport
D1815_RS09295	COG0561	phosphatase activity
D1815_RS09335	COG5002	protein histidine kinase activity
D1815_RS09355	COG0037	tRNA processing
D1815_RS09400	COG2133	pyrroloquinoline quinone binding
D1815_RS09405	COG2010	Cytochrome c
D1815_RS09420	COG0572	uridine kinase
D1815_RS09430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1815_RS09430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1815_RS09440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1815_RS09440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1815_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS09450	COG0612	Peptidase, M16
D1815_RS09460	COG1192	Involved in chromosome partitioning
D1815_RS09465	COG1475	DNA binding
D1815_RS09475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1815_RS09480	COG0681	Belongs to the peptidase S26 family
D1815_RS09515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D1815_RS09525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1815_RS09535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1815_RS09550	COG1607	acyl-coa hydrolase
D1815_RS09570	COG1595	DNA-templated transcription, initiation
D1815_RS09585	COG0105	UTP biosynthetic process
D1815_RS09595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1815_RS09605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1815_RS09610	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1815_RS09620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1815_RS09635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1815_RS09655	COG0305	Participates in initiation and elongation during chromosome replication
D1815_RS09660	COG0825	malonyl-CoA metabolic process
D1815_RS09675	COG0343	queuine tRNA-ribosyltransferase activity
D1815_RS09680	COG3959	Transketolase, thiamine diphosphate binding domain
D1815_RS09685	COG3958	Transketolase
D1815_RS09700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1815_RS09710	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1815_RS09715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1815_RS09740	COG0739	heme binding
D1815_RS09745	COG1629	transport
D1815_RS09745	COG4206	TonB-dependent receptor
D1815_RS09755	COG1595	DNA-templated transcription, initiation
D1815_RS09765	COG1233	COG1233 Phytoene dehydrogenase and related
D1815_RS09780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1815_RS09815	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D1815_RS09860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1815_RS09870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1815_RS09885	COG0714	Associated with various cellular activities
D1815_RS09900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1815_RS09915	COG0516	GMP reductase activity
D1815_RS09915	COG0517	IMP dehydrogenase activity
D1815_RS09920	COG0671	phosphoesterase, PA-phosphatase related
D1815_RS09955	COG0596	Alpha beta hydrolase
D1815_RS09960	COG1278	Cold shock
D1815_RS10005	COG1528	Iron-storage protein
D1815_RS10015	COG0045	succinate-CoA ligase (ADP-forming) activity
D1815_RS10025	COG0019	diaminopimelate decarboxylase activity
D1815_RS10030	COG3530	Putative quorum-sensing-regulated virulence factor
D1815_RS10040	COG1388	LysM domain
D1815_RS10040	COG0791	NLP P60 protein
D1815_RS10045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1815_RS10045	COG0519	Catalyzes the synthesis of GMP from XMP
D1815_RS10055	COG0259	pyridoxamine-phosphate oxidase activity
D1815_RS10075	COG1733	regulation of RNA biosynthetic process
D1815_RS10095	COG0300	oxidoreductase activity
D1815_RS10105	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D1815_RS10125	COG0612	Peptidase, M16
D1815_RS10145	COG1741	Belongs to the pirin family
D1815_RS10150	COG0778	Nitroreductase
D1815_RS10155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1815_RS10165	COG0154	amidase activity
D1815_RS10175	COG0552	protein localization to endoplasmic reticulum
D1815_RS10185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1815_RS10190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1815_RS10210	COG1058	Belongs to the CinA family
D1815_RS10210	COG1546	Belongs to the CinA family
D1815_RS10220	COG4771	TonB-dependent receptor
D1815_RS10225	COG4232	protein-disulfide reductase activity
D1815_RS10230	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1815_RS10245	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1815_RS10250	COG1121	(ABC) transporter
D1815_RS10255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1815_RS10260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1815_RS10290	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1815_RS10295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1815_RS10295	COG1215	transferase activity, transferring glycosyl groups
D1815_RS10300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1815_RS10305	COG2096	Adenosyltransferase
D1815_RS10315	COG0653	protein targeting
D1815_RS10325	COG1695	Transcriptional regulator
D1815_RS10345	COG2072	flavoprotein involved in K transport
D1815_RS10355	COG1595	DNA-templated transcription, initiation
D1815_RS10395	COG1233	COG1233 Phytoene dehydrogenase and related
D1815_RS10405	COG1703	isobutyryl-CoA mutase activity
D1815_RS10415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1815_RS10425	COG0671	phosphoesterase, PA-phosphatase related
D1815_RS10440	COG0534	Mate efflux family protein
D1815_RS10460	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D1815_RS10490	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1815_RS10505	COG2326	polyphosphate kinase activity
D1815_RS10525	COG3264	Mechanosensitive ion channel
D1815_RS10525	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1815_RS10530	COG1668	transmembrane transport
D1815_RS10535	COG4152	abc transporter atp-binding protein
D1815_RS10540	COG0484	heat shock protein binding
D1815_RS10545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1815_RS10555	COG1090	epimerase
D1815_RS10560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1815_RS10560	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1815_RS10570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1815_RS10600	COG2197	response regulator
D1815_RS10630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1815_RS10665	COG0668	transmembrane transport
D1815_RS10670	COG1115	amino acid carrier protein
D1815_RS10680	COG1522	sequence-specific DNA binding
D1815_RS10700	COG1228	amidohydrolase
D1815_RS10705	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1815_RS10705	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1815_RS10705	COG1703	isobutyryl-CoA mutase activity
D1815_RS10715	COG0788	formyltetrahydrofolate deformylase activity
D1815_RS10730	COG4771	TonB-dependent receptor
D1815_RS10750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1815_RS10755	COG0284	orotidine-5'-phosphate decarboxylase activity
D1815_RS10770	COG2217	Heavy metal translocating P-type atpase
D1815_RS10800	COG1910	domain protein
D1815_RS10835	COG2197	response regulator
D1815_RS10840	COG0739	heme binding
D1815_RS10850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1815_RS10855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1815_RS10865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1815_RS10880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1815_RS10885	COG0512	Glutamine amidotransferase of anthranilate synthase
D1815_RS10890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1815_RS10895	COG0134	indole-3-glycerol-phosphate synthase activity
D1815_RS10900	COG0135	phosphoribosylanthranilate isomerase activity
D1815_RS10905	COG0133	tryptophan synthase activity
D1815_RS10910	COG0159	tryptophan synthase activity
D1815_RS10925	COG3738	Protein conserved in bacteria
D1815_RS10940	COG1696	Membrane protein involved in D-alanine export
D1815_RS10965	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D1815_RS10970	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1815_RS10985	COG3022	response to hydroperoxide
D1815_RS10995	COG1278	Cold shock
D1815_RS11000	COG0564	pseudouridine synthase activity
D1815_RS11010	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1815_RS11015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1815_RS11025	COG0346	lactoylglutathione lyase activity
D1815_RS11050	COG0659	secondary active sulfate transmembrane transporter activity
D1815_RS11060	COG1131	(ABC) transporter
D1815_RS11090	COG0463	Glycosyl transferase, family 2
D1815_RS11115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1815_RS11130	COG0799	negative regulation of ribosome biogenesis
D1815_RS11135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1815_RS11145	COG4589	Belongs to the CDS family
D1815_RS11150	COG0688	phosphatidylethanolamine metabolic process
D1815_RS11160	COG0525	valine-tRNA ligase activity
D1815_RS11175	COG0436	Aminotransferase
D1815_RS11180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1815_RS11200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1815_RS11205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1815_RS11215	COG1663	tetraacyldisaccharide 4'-kinase activity
D1815_RS11220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1815_RS11240	COG0268	Binds directly to 16S ribosomal RNA
D1815_RS11255	COG0442	prolyl-tRNA aminoacylation
D1815_RS11280	COG0302	gtp cyclohydrolase
D1815_RS11285	COG0215	cysteine-tRNA ligase activity
D1815_RS11295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1815_RS11310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1815_RS11325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1815_RS11330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1815_RS11370	COG0174	glutamine synthetase
D1815_RS11400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1815_RS11430	COG1595	DNA-templated transcription, initiation
D1815_RS11460	COG2264	protein methyltransferase activity
D1815_RS11465	COG0149	triose-phosphate isomerase activity
D1815_RS11470	COG0601	transmembrane transport
D1815_RS11485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1815_RS11490	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D1815_RS11505	COG1132	(ABC) transporter
D1815_RS11510	COG0101	tRNA pseudouridine synthase activity
D1815_RS11540	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1815_RS11545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1815_RS11550	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1815_RS11555	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1815_RS11585	COG2198	Histidine kinase
D1815_RS11585	COG0784	Response regulator, receiver
D1815_RS11585	COG5002	protein histidine kinase activity
D1815_RS11590	COG0018	arginyl-trna synthetase
D1815_RS11600	COG0702	epimerase
D1815_RS11610	COG1959	2 iron, 2 sulfur cluster binding
D1815_RS11630	COG0148	phosphopyruvate hydratase activity
D1815_RS11635	COG0505	Belongs to the CarA family
D1815_RS11640	COG0203	ribosomal protein L17
D1815_RS11645	COG0202	RNA polymerase activity
D1815_RS11650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1815_RS11655	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1815_RS11660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1815_RS11665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1815_RS11670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1815_RS11680	COG0200	Binds to the 23S rRNA
D1815_RS11685	COG1841	ribosomal large subunit assembly
D1815_RS11690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1815_RS11695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1815_RS11700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1815_RS11705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1815_RS11710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1815_RS11715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1815_RS11720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1815_RS11725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1815_RS11730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1815_RS11735	COG0255	Belongs to the universal ribosomal protein uL29 family
D1815_RS11740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1815_RS11745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1815_RS11750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1815_RS11755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1815_RS11760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1815_RS11765	COG0089	rRNA binding
D1815_RS11770	COG0088	Forms part of the polypeptide exit tunnel
D1815_RS11775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1815_RS11780	COG0051	transcription antitermination factor activity, RNA binding
D1815_RS11785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1815_RS11790	COG0049	tRNA binding
D1815_RS11795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1815_RS11805	COG1629	transport
D1815_RS11805	COG4206	TonB-dependent receptor
D1815_RS11820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1815_RS11830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1815_RS11860	COG2003	Belongs to the UPF0758 family
D1815_RS11890	COG2373	Large extracellular alpha-helical protein
D1815_RS11910	COG2169	Transcriptional regulator
D1815_RS11980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS12010	COG1629	transport
D1815_RS12010	COG4206	TonB-dependent receptor
D1815_RS12030	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1815_RS12035	COG1473	amidohydrolase
D1815_RS12050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1815_RS12065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1815_RS12070	COG0563	adenylate kinase activity
D1815_RS12075	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1815_RS12080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1815_RS12085	COG0339	signal peptide processing
D1815_RS12090	COG1510	regulation of RNA biosynthetic process
D1815_RS12120	COG1090	epimerase
D1815_RS12155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1815_RS12155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1815_RS12165	COG1199	ATP-dependent helicase activity
D1815_RS12165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1815_RS12175	COG3420	alginic acid biosynthetic process
D1815_RS12180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1815_RS12180	COG2169	Transcriptional regulator
D1815_RS12190	COG2819	hydrolase of the alpha beta superfamily
D1815_RS12210	COG1132	(ABC) transporter
D1815_RS12240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1815_RS12250	COG1215	transferase activity, transferring glycosyl groups
D1815_RS12260	COG1309	transcriptional regulator
D1815_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS12285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1815_RS12315	COG2304	oxidoreductase activity
D1815_RS12350	COG0494	nUDIX hydrolase
D1815_RS12360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1815_RS12365	COG0295	cytidine deaminase activity
D1815_RS12380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1815_RS12385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1815_RS12395	COG0668	transmembrane transport
D1815_RS12420	COG4615	Cyclic peptide transporter
D1815_RS12440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1815_RS12500	COG4977	sequence-specific DNA binding
D1815_RS12500	COG1917	Cupin 2, conserved barrel domain protein
D1815_RS12505	COG1770	oligopeptidase
D1815_RS12515	COG0285	dihydrofolate synthase activity
D1815_RS12525	COG0848	biopolymer transport protein
D1815_RS12530	COG0811	peptide transport
D1815_RS12535	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1815_RS12545	COG1960	acyl-CoA dehydrogenase activity
D1815_RS12605	COG1629	transport
D1815_RS12615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1815_RS12635	COG0321	lipoyl(octanoyl) transferase activity
D1815_RS12650	COG0401	homolog of Blt101
D1815_RS12655	COG2197	response regulator
D1815_RS12695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1815_RS12750	COG4682	membrane
D1815_RS12770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1815_RS12805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1815_RS12825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1815_RS12835	COG1473	amidohydrolase
D1815_RS12860	COG0629	single-stranded DNA binding
D1815_RS12870	COG0069	glutamate synthase activity
D1815_RS12885	COG0028	Belongs to the TPP enzyme family
D1815_RS12905	COG4585	Histidine kinase
D1815_RS12970	COG1690	Belongs to the RtcB family
D1815_RS12975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1815_RS13010	COG1858	cytochrome C peroxidase
D1815_RS13015	COG1858	cytochrome C peroxidase
D1815_RS13050	COG0464	growth
D1815_RS13060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D1815_RS13200	COG0022	dehydrogenase e1 component
D1815_RS13205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1815_RS13210	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1815_RS13225	COG1012	belongs to the aldehyde dehydrogenase family
D1815_RS13225	COG2030	dehydratase
D1815_RS13230	COG0183	Belongs to the thiolase family
D1815_RS13245	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1815_RS13250	COG1024	Enoyl-CoA hydratase
D1815_RS13260	COG2151	metal-sulfur cluster biosynthetic enzyme
D1815_RS13265	COG3396	Phenylacetate-CoA oxygenase
D1815_RS13270	COG3460	Phenylacetate-CoA oxygenase
D1815_RS13275	COG3396	Phenylacetate-CoA oxygenase
D1815_RS13280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1815_RS13285	COG1309	transcriptional regulator
D1815_RS13300	COG3186	Phenylalanine-4-hydroxylase
D1815_RS13320	COG4733	cellulase activity
D1815_RS13320	COG5297	Belongs to the glycosyl hydrolase family 6
D1815_RS13340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1815_RS13365	COG1160	GTP binding
D1815_RS13380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1815_RS13390	COG1115	amino acid carrier protein
D1815_RS13405	COG0745	RESPONSE REGULATOR receiver
D1815_RS13405	COG2972	Histidine kinase
D1815_RS13410	COG3279	Response regulator of the LytR AlgR family
D1815_RS13420	COG1509	lysine 2,3-aminomutase activity
D1815_RS13425	COG1944	ATP diphosphatase activity
D1815_RS13495	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D1815_RS13500	COG0076	glutamate decarboxylase activity
D1815_RS13505	COG1595	DNA-templated transcription, initiation
D1815_RS13545	COG0778	Nitroreductase
D1815_RS13645	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1815_RS13660	COG4948	Mandelate Racemase Muconate Lactonizing
D1815_RS13665	COG1012	belongs to the aldehyde dehydrogenase family
D1815_RS13670	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS13675	COG1063	alcohol dehydrogenase
D1815_RS13685	COG3250	beta-galactosidase activity
D1815_RS13705	COG2124	cytochrome p450
D1815_RS13750	COG1609	Transcriptional regulator
D1815_RS13755	COG1085	galactose-1-phosphate uridylyltransferase
D1815_RS13760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1815_RS13790	COG4771	TonB-dependent receptor
D1815_RS13795	COG0561	phosphatase activity
D1815_RS13840	COG0800	Aldolase
D1815_RS13850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1815_RS13855	COG0066	3-isopropylmalate dehydratase activity
D1815_RS13865	COG0473	3-isopropylmalate dehydrogenase activity
D1815_RS13870	COG0463	Glycosyl transferase, family 2
D1815_RS13925	COG3279	Response regulator of the LytR AlgR family
D1815_RS13935	COG5002	protein histidine kinase activity
D1815_RS13945	COG4251	negative regulation of phosphorylation
D1815_RS13955	COG5002	protein histidine kinase activity
D1815_RS13965	COG0784	Response regulator, receiver
D1815_RS13995	COG0488	(ABC) transporter
D1815_RS14005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1815_RS14025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1815_RS14035	COG1754	DNA topoisomerase type I activity
D1815_RS14035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1815_RS14045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1815_RS14050	COG3829	transcription factor binding
D1815_RS14070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1815_RS14075	COG0459	protein refolding
D1815_RS14090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1815_RS14105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1815_RS14130	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1815_RS14145	COG1725	Transcriptional regulator
D1815_RS14150	COG4771	TonB-dependent receptor
D1815_RS14155	COG0702	epimerase
D1815_RS14170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1815_RS14175	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1815_RS14180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1815_RS14185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1815_RS14190	COG1253	flavin adenine dinucleotide binding
D1815_RS14215	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1815_RS14260	COG1629	transport
D1815_RS14265	COG0366	Alpha amylase catalytic
D1815_RS14275	COG1554	hydrolase, family 65, central catalytic
D1815_RS14280	COG1609	Transcriptional regulator
D1815_RS14290	COG1472	Belongs to the glycosyl hydrolase 3 family
D1815_RS14295	COG1472	Belongs to the glycosyl hydrolase 3 family
D1815_RS14300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1815_RS14315	COG1054	Belongs to the UPF0176 family
D1815_RS14325	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1815_RS14370	COG2207	Transcriptional regulator
D1815_RS14375	COG2084	Dehydrogenase
D1815_RS14380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1815_RS14440	COG5002	protein histidine kinase activity
D1815_RS14445	COG5002	protein histidine kinase activity
D1815_RS14445	COG0784	Response regulator, receiver
D1815_RS14455	COG0463	Glycosyl transferase, family 2
D1815_RS14460	COG1215	transferase activity, transferring glycosyl groups
D1815_RS14485	COG1187	pseudouridine synthase activity
D1815_RS14515	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D1815_RS14520	COG1309	transcriptional regulator
D1815_RS14535	COG2081	HI0933 family
D1815_RS14540	COG0584	glycerophosphoryl diester phosphodiesterase
D1815_RS14545	COG1960	acyl-CoA dehydrogenase activity
D1815_RS14555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D1815_RS14560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1815_RS14565	COG0228	four-way junction DNA binding
D1815_RS14625	COG0644	oxidoreductase
D1815_RS14665	COG0489	protein tyrosine kinase activity
D1815_RS14685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1815_RS14690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1815_RS14695	COG5002	protein histidine kinase activity
D1815_RS14700	COG0745	RESPONSE REGULATOR receiver
D1815_RS14715	COG1629	transport
D1815_RS14725	COG4771	TonB-dependent receptor
D1815_RS14735	COG0534	Mate efflux family protein
D1815_RS14755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1815_RS14785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1815_RS14790	COG0463	Glycosyl transferase, family 2
D1815_RS14805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D1815_RS14810	COG2363	Small membrane protein
D1815_RS14820	COG1522	sequence-specific DNA binding
D1815_RS14850	COG0495	leucyl-tRNA aminoacylation
D1815_RS14855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1815_RS14860	COG2177	Part of the ABC transporter FtsEX involved in
D1815_RS14865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1815_RS14880	COG1968	undecaprenyl-diphosphatase activity
D1815_RS14885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1815_RS14900	COG0519	Catalyzes the synthesis of GMP from XMP
D1815_RS14910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1815_RS14915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D1815_RS14925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1815_RS14930	COG3852	Histidine kinase
D1815_RS14950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1815_RS14965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1815_RS14970	COG2022	thiamine diphosphate biosynthetic process
D1815_RS14975	COG0352	thiamine-phosphate diphosphorylase activity
D1815_RS14980	COG0351	phosphomethylpyrimidine kinase
D1815_RS14990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1815_RS15010	COG2204	response regulator
D1815_RS15020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1815_RS15035	COG3201	nicotinamide mononucleotide transporter
D1815_RS15050	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1815_RS15075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1815_RS15080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1815_RS15090	COG0612	Peptidase, M16
D1815_RS15115	COG0629	single-stranded DNA binding
D1815_RS15120	COG1194	a g-specific adenine glycosylase
D1815_RS15125	COG0776	regulation of translation
D1815_RS15130	COG1530	ribonuclease E activity
D1815_RS15135	COG2137	regulation of response to DNA damage stimulus
D1815_RS15155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1815_RS15160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1815_RS15165	COG3279	Response regulator of the LytR AlgR family
D1815_RS15190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1815_RS15195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1815_RS15200	COG0156	8-amino-7-oxononanoate synthase activity
D1815_RS15215	COG3655	Transcriptional regulator
D1815_RS15235	COG4946	Tricorn protease homolog
D1815_RS15235	COG0823	Involved in the tonB-independent uptake of proteins
D1815_RS15235	COG1506	peptidase
D1815_RS15275	COG4771	TonB-dependent receptor
D1815_RS15280	COG4771	TonB-dependent receptor
D1815_RS15285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1815_RS15295	COG0297	glycogen (starch) synthase activity
D1815_RS15300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1815_RS15305	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D1815_RS15320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1815_RS15325	COG0667	Aldo Keto reductase
D1815_RS15355	COG0708	Exodeoxyribonuclease III
D1815_RS15385	COG0423	glycine-tRNA ligase activity
D1815_RS15425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1815_RS15435	COG1595	DNA-templated transcription, initiation
D1815_RS15460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1815_RS15465	COG2201	protein-glutamate methylesterase activity
D1815_RS15470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1815_RS15480	COG0189	ligase activity
D1815_RS15490	COG0322	excinuclease ABC activity
D1815_RS15500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1815_RS15505	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D1815_RS15525	COG0166	Belongs to the GPI family
D1815_RS15575	COG0432	Pfam Uncharacterised protein family UPF0047
D1815_RS15590	COG0561	phosphatase activity
D1815_RS15595	COG0481	GTPase activity
D1815_RS15610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1815_RS15615	COG0346	lactoylglutathione lyase activity
D1815_RS15625	COG3279	Response regulator of the LytR AlgR family
D1815_RS15630	COG2972	Histidine kinase
D1815_RS15655	COG0307	riboflavin synthase, alpha
D1815_RS15660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D1815_RS15670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1815_RS15675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1815_RS15680	COG0511	ligase activity, forming carbon-carbon bonds
D1815_RS15685	COG0439	Biotin carboxylase
D1815_RS15695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1815_RS15700	COG3485	protocatechuate 3,4-dioxygenase
D1815_RS15715	COG0596	Alpha beta hydrolase
D1815_RS15725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D1815_RS15725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1815_RS15740	COG4585	Histidine kinase
D1815_RS15775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1815_RS15790	COG1435	thymidine kinase activity
D1815_RS15795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1815_RS15800	COG1970	mechanosensitive ion channel activity
D1815_RS15805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1815_RS15820	COG1505	serine-type exopeptidase activity
D1815_RS15835	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1815_RS15840	COG0720	synthase
D1815_RS15860	COG0534	Mate efflux family protein
D1815_RS15905	COG1012	belongs to the aldehyde dehydrogenase family
D1815_RS15935	COG0783	Belongs to the Dps family
D1815_RS15965	COG0668	transmembrane transport
D1815_RS16040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1815_RS16085	COG1295	ribonuclease BN
D1815_RS16110	COG0702	epimerase
D1815_RS16115	COG1629	transport
D1815_RS16120	COG1472	Belongs to the glycosyl hydrolase 3 family
D1815_RS16125	COG0745	RESPONSE REGULATOR receiver
D1815_RS16125	COG2205	protein histidine kinase activity
D1815_RS16125	COG3292	Two component regulator propeller
D1815_RS16140	COG0726	polysaccharide deacetylase
D1815_RS16155	COG2115	Belongs to the xylose isomerase family
D1815_RS16160	COG1070	Carbohydrate kinase
D1815_RS16205	COG0210	DNA helicase
D1815_RS16215	COG1074	ATP-dependent DNA helicase activity
D1815_RS16245	COG3341	Caulimovirus viroplasmin
D1815_RS16245	COG0328	RNA-DNA hybrid ribonuclease activity
D1815_RS16255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1815_RS16260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1815_RS16265	COG0571	ribonuclease III activity
D1815_RS16275	COG0469	pyruvate kinase activity
D1815_RS16385	COG2205	protein histidine kinase activity
D1815_RS16385	COG0784	Response regulator, receiver
D1815_RS16405	COG0006	proline dipeptidase activity
D1815_RS16425	COG2267	carboxylic ester hydrolase activity
D1815_RS16435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1815_RS16470	COG1858	cytochrome C peroxidase
D1815_RS16480	COG3275	phosphorelay sensor kinase activity
D1815_RS16490	COG0316	Belongs to the HesB IscA family
D1815_RS16495	COG0719	Fe-S assembly protein
D1815_RS16505	COG0396	ATPase activity
D1815_RS16510	COG0719	Fe-S assembly protein
D1815_RS16520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1815_RS16525	COG2166	iron-sulfur cluster assembly
D1815_RS16530	COG2151	metal-sulfur cluster biosynthetic enzyme
D1815_RS16555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1815_RS16595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1815_RS16615	COG0594	ribonuclease P activity
D1815_RS16620	COG0793	Belongs to the peptidase S41A family
D1815_RS16625	COG2153	protein acetylation
D1815_RS16630	COG0698	ribose 5-phosphate isomerase
D1815_RS16645	COG0557	exoribonuclease II activity
D1815_RS16670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1815_RS16680	COG0330	HflC and HflK could
D1815_RS16690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1815_RS16695	COG3239	Fatty acid desaturase
D1815_RS16705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1815_RS16710	COG0445	tRNA wobble uridine modification
D1815_RS16755	COG0470	DNA polymerase III
D1815_RS16760	COG0126	phosphoglycerate kinase activity
D1815_RS16765	COG0741	lytic transglycosylase activity
D1815_RS16765	COG1388	LysM domain
D1815_RS16785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1815_RS16820	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D1815_RS16835	COG1482	cell wall glycoprotein biosynthetic process
D1815_RS16840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D1815_RS16850	COG2244	polysaccharide biosynthetic process
D1815_RS16855	COG0110	maltose O-acetyltransferase activity
D1815_RS16885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1815_RS16900	COG0463	Glycosyl transferase, family 2
D1815_RS16905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1815_RS16915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D1815_RS16955	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D1815_RS16960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1815_RS16965	COG0438	transferase activity, transferring glycosyl groups
D1815_RS16970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1815_RS16980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1815_RS16995	COG0151	Belongs to the GarS family
D1815_RS17025	COG0859	PFAM glycosyl transferase family 9
D1815_RS17030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1815_RS17080	COG0356	it plays a direct role in the translocation of protons across the membrane
D1815_RS17085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1815_RS17090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1815_RS17095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1815_RS17100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1815_RS17105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1815_RS17130	COG0756	dUTP diphosphatase activity
D1815_RS17135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D1815_RS17170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1815_RS17170	COG0758	DNA mediated transformation
D1815_RS17190	COG2897	thiosulfate sulfurtransferase activity
D1815_RS17200	COG4628	conserved protein (DUF2132)
D1815_RS17205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1815_RS17220	COG0662	Cupin 2, conserved barrel domain protein
D1815_RS17225	COG1012	belongs to the aldehyde dehydrogenase family
D1815_RS17255	COG4260	virion core protein, lumpy skin disease virus
D1815_RS17270	COG4172	Belongs to the ABC transporter superfamily
D1815_RS17285	COG1024	Enoyl-CoA hydratase
D1815_RS17295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1815_RS17300	COG0194	GDP metabolic process
D1815_RS17305	COG1561	YicC-like family, N-terminal region
D1815_RS17315	COG1981	membrane
D1815_RS17335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1815_RS17350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1815_RS17355	COG0181	hydroxymethylbilane synthase activity
D1815_RS17365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1815_RS17375	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D1815_RS17380	COG0408	coproporphyrinogen oxidase activity
D1815_RS17435	COG2312	Erythromycin esterase
D1815_RS17460	COG1131	(ABC) transporter
D1815_RS17465	COG0113	porphobilinogen synthase activity
D1815_RS17485	COG1253	flavin adenine dinucleotide binding
D1815_RS17490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1815_RS17495	COG3275	phosphorelay sensor kinase activity
D1815_RS17540	COG4221	oxidoreductase activity
D1815_RS17545	COG0714	Associated with various cellular activities
D1815_RS17560	COG2304	oxidoreductase activity
D1815_RS17565	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1815_RS17570	COG2304	oxidoreductase activity
D1815_RS17590	COG2311	Membrane
D1815_RS17600	COG0659	secondary active sulfate transmembrane transporter activity
D1815_RS17610	COG0659	secondary active sulfate transmembrane transporter activity
D1815_RS17625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1815_RS17660	COG0180	Tryptophanyl-tRNA synthetase
D1815_RS17685	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1815_RS17690	COG1054	Belongs to the UPF0176 family
D1815_RS17695	COG1774	PSP1 C-terminal conserved region
D1815_RS17705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1815_RS17710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1815_RS17715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D1815_RS17740	COG0429	hydrolase of the alpha beta-hydrolase fold
D1815_RS17745	COG3781	membrane
D1815_RS17775	COG0626	cystathionine gamma-synthase activity
D1815_RS17780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1815_RS17790	COG1381	Involved in DNA repair and RecF pathway recombination
D1815_RS17795	COG4771	TonB-dependent receptor
D1815_RS17865	COG1309	transcriptional regulator
D1815_RS17900	COG0577	efflux transmembrane transporter activity
D1815_RS17900	COG1136	(ABC) transporter
D1815_RS17905	COG1136	(ABC) transporter
D1815_RS17945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS17960	COG0750	zinc metalloprotease
D1815_RS17965	COG1999	signal sequence binding
D1815_RS18000	COG1233	COG1233 Phytoene dehydrogenase and related
D1815_RS18045	COG1418	mRNA catabolic process
D1815_RS18070	COG2373	Large extracellular alpha-helical protein
D1815_RS18075	COG1881	PFAM PEBP family protein
D1815_RS18095	COG0784	Response regulator, receiver
D1815_RS18095	COG5002	protein histidine kinase activity
D1815_RS18095	COG2198	Histidine kinase
D1815_RS18100	COG5002	protein histidine kinase activity
D1815_RS18100	COG0784	Response regulator, receiver
D1815_RS18100	COG2198	Histidine kinase
D1815_RS18105	COG4953	penicillin-binding protein 1C
D1815_RS18115	COG2954	triphosphatase activity
D1815_RS18135	COG0702	epimerase
D1815_RS18145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1815_RS18155	COG0436	Aminotransferase
D1815_RS18165	COG1053	succinate dehydrogenase
D1815_RS18170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1815_RS18195	COG0517	IMP dehydrogenase activity
D1815_RS18195	COG0516	GMP reductase activity
D1815_RS18210	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1815_RS18215	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1815_RS18225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1815_RS18225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1815_RS18250	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1815_RS18255	COG0792	nuclease activity
D1815_RS18260	COG0667	Aldo Keto reductase
D1815_RS18290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1815_RS18295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1815_RS18310	COG1201	RNA secondary structure unwinding
D1815_RS18315	COG1793	dna ligase
D1815_RS18330	COG0784	Response regulator, receiver
D1815_RS18330	COG2205	protein histidine kinase activity
D1815_RS18350	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D1815_RS18360	COG0527	aspartate kinase activity
D1815_RS18370	COG0668	transmembrane transport
D1815_RS18375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1815_RS18380	COG1247	-acetyltransferase
D1815_RS18415	COG2197	response regulator
D1815_RS18425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1815_RS18440	COG0673	inositol 2-dehydrogenase activity
D1815_RS18455	COG2239	Acts as a magnesium transporter
D1815_RS18460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1815_RS18480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1815_RS18500	COG0196	riboflavin kinase activity
D1815_RS18505	COG0193	aminoacyl-tRNA hydrolase activity
D1815_RS18510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1815_RS18515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1815_RS18535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1815_RS18575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1815_RS18595	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS18600	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D1815_RS18605	COG1312	Catalyzes the dehydration of D-mannonate
D1815_RS18610	COG1028	Short-chain dehydrogenase reductase Sdr
D1815_RS18620	COG3292	Two component regulator propeller
D1815_RS18620	COG2205	protein histidine kinase activity
D1815_RS18620	COG0745	RESPONSE REGULATOR receiver
D1815_RS18625	COG4771	TonB-dependent receptor
D1815_RS18630	COG0702	epimerase
D1815_RS18635	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D1815_RS18640	COG3250	beta-galactosidase activity
D1815_RS18645	COG1904	glucuronate isomerase
D1815_RS18650	COG0668	transmembrane transport
D1815_RS18685	COG2095	MarC family integral membrane protein
D1815_RS18730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1815_RS18730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1815_RS18735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1815_RS18745	COG1404	Belongs to the peptidase S8 family
D1815_RS18750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1815_RS18755	COG0590	tRNA wobble adenosine to inosine editing
D1815_RS18780	COG1278	Cold shock
D1815_RS18800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1815_RS18805	COG4771	TonB-dependent receptor
D1815_RS18815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1815_RS18830	COG1309	transcriptional regulator
D1815_RS18865	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1815_RS18870	COG3291	Pkd domain containing protein
D1815_RS18880	COG1131	(ABC) transporter
D1815_RS18890	COG1506	peptidase
D1815_RS18890	COG0823	Involved in the tonB-independent uptake of proteins
D1815_RS18895	COG3104	oligopeptide transport
D1815_RS18920	COG2333	competence protein COMEC
D1815_RS18920	COG0658	competence protein
D1815_RS18930	COG0791	NLP P60 protein
D1815_RS18935	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1815_RS18945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D1815_RS18955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1815_RS18980	COG0772	Belongs to the SEDS family
D1815_RS18985	COG0768	penicillin binding
D1815_RS19000	COG1077	Cell shape determining protein MreB Mrl
D1815_RS19005	COG0138	bifunctional purine biosynthesis protein purh
D1815_RS19030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1815_RS19065	COG0084	hydrolase, TatD family'
D1815_RS19070	COG0252	asparaginase activity
D1815_RS19080	COG0811	peptide transport
D1815_RS19090	COG0848	biopolymer transport protein
D1815_RS19120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D1815_RS19125	COG2197	response regulator
D1815_RS19130	COG4585	Histidine kinase
D1815_RS19165	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D1815_RS19180	COG2255	four-way junction helicase activity
D1815_RS19215	COG0393	Putative heavy-metal-binding
D1815_RS19220	COG1842	Phage shock protein A
D1815_RS19230	COG1396	sequence-specific DNA binding
D1815_RS19245	COG0017	Asparaginyl-tRNA synthetase
D1815_RS19260	COG0233	cytoplasmic translational termination
D1815_RS19265	COG0528	UMP kinase activity
D1815_RS19270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1815_RS19275	COG0052	Belongs to the universal ribosomal protein uS2 family
D1815_RS19280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1815_RS19285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1815_RS19305	COG1253	flavin adenine dinucleotide binding
D1815_RS19310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1815_RS19310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1815_RS19320	COG3118	belongs to the thioredoxin family
D1815_RS19345	COG0779	Required for maturation of 30S ribosomal subunits
D1815_RS19350	COG0195	Participates in both transcription termination and antitermination
D1815_RS19355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1815_RS19370	COG0437	4 iron, 4 sulfur cluster binding
D1815_RS19375	COG3743	rRNA binding
D1815_RS19375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1815_RS19395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1815_RS19400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1815_RS19410	COG2255	four-way junction helicase activity
D1815_RS19430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1815_RS19445	COG0280	phosphate acetyltransferase
D1815_RS19445	COG0281	malic enzyme
D1815_RS19450	COG0632	four-way junction helicase activity
D1815_RS19460	COG0509	glycine decarboxylation via glycine cleavage system
D1815_RS19485	COG0109	protoheme IX farnesyltransferase activity
D1815_RS19490	COG1845	cytochrome c oxidase, subunit III
D1815_RS19495	COG1845	cytochrome c oxidase, subunit III
D1815_RS19510	COG1999	signal sequence binding
D1815_RS19515	COG2322	membrane
D1815_RS19525	COG1136	(ABC) transporter
D1815_RS19530	COG0577	efflux transmembrane transporter activity
D1815_RS19530	COG1136	(ABC) transporter
D1815_RS19535	COG1136	(ABC) transporter
D1815_RS19535	COG0577	efflux transmembrane transporter activity
D1815_RS19540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1815_RS19555	COG1214	PFAM Peptidase M22, glycoprotease
D1815_RS19590	COG3275	phosphorelay sensor kinase activity
D1815_RS19595	COG3279	Response regulator of the LytR AlgR family
D1815_RS19605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1815_RS19625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1815_RS19635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1815_RS19645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D1815_RS19650	COG0596	Alpha beta hydrolase
D1815_RS19665	COG1950	PFAM Membrane protein of
D1815_RS19670	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1815_RS19680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1815_RS19700	COG0076	glutamate decarboxylase activity
D1815_RS19750	COG1428	Deoxynucleoside kinase
D1815_RS19770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1815_RS19790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1815_RS19885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1815_RS19890	COG0583	DNA-binding transcription factor activity
D1815_RS19905	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1815_RS19915	COG0363	glucosamine-6-phosphate deaminase activity
D1815_RS19925	COG1629	transport
D1815_RS19930	COG3275	phosphorelay sensor kinase activity
D1815_RS19935	COG3279	Response regulator of the LytR AlgR family
D1815_RS19975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1815_RS20015	COG2197	response regulator
D1815_RS20030	COG2885	chlorophyll binding
D1815_RS20060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1815_RS20065	COG3938	Belongs to the proline racemase family
D1815_RS20075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1815_RS20085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1815_RS20115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1815_RS20120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1815_RS20140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1815_RS20190	COG2852	Protein conserved in bacteria
D1815_RS20205	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D1815_RS20210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1815_RS20220	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1815_RS20220	COG0022	dehydrogenase e1 component
D1815_RS20225	COG2086	electron transfer activity
D1815_RS20230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1815_RS20240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1815_RS20245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D1815_RS20255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1815_RS20260	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D1815_RS20285	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1815_RS20305	COG3275	phosphorelay sensor kinase activity
D1815_RS20310	COG3279	Response regulator of the LytR AlgR family
D1815_RS20315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1815_RS20330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1815_RS20335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1815_RS20345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1815_RS20380	COG1428	Deoxynucleoside kinase
D1815_RS20400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1815_RS20545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1815_RS20555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1815_RS20560	COG0460	homoserine dehydrogenase
D1815_RS20560	COG0527	aspartate kinase activity
D1815_RS20565	COG1765	OsmC-like protein
D1815_RS20590	COG0175	sulfate reduction
D1815_RS20600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1815_RS20610	COG1648	precorrin-2 dehydrogenase activity
D1815_RS20610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1815_RS20615	COG0492	ferredoxin-NADP+ reductase activity
D1815_RS20625	COG1410	methionine synthase
D1815_RS20625	COG0646	methionine synthase
D1815_RS20635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1815_RS20650	COG5001	Diguanylate cyclase
D1815_RS20650	COG5002	protein histidine kinase activity
D1815_RS20650	COG3447	MASE1 domain protein
D1815_RS20660	COG0745	RESPONSE REGULATOR receiver
D1815_RS20670	COG2723	6-phospho-beta-galactosidase activity
D1815_RS20675	COG1522	sequence-specific DNA binding
D1815_RS20680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1815_RS20685	COG0156	8-amino-7-oxononanoate synthase activity
D1815_RS20690	COG0077	Prephenate dehydratase
D1815_RS20690	COG1605	Chorismate mutase
D1815_RS20695	COG0436	Aminotransferase
D1815_RS20700	COG0287	Prephenate dehydrogenase
D1815_RS20705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D1815_RS20710	COG1162	GTPase activity
D1815_RS20715	COG1490	D-aminoacyl-tRNA deacylase activity
D1815_RS20735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1815_RS20745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1815_RS20760	COG1595	DNA-templated transcription, initiation
D1815_RS20775	COG4733	cellulase activity
D1815_RS20775	COG5297	Belongs to the glycosyl hydrolase family 6
D1815_RS20780	COG0358	DNA primase activity
D1815_RS20790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1815_RS20810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1815_RS20820	COG2001	Belongs to the MraZ family
D1815_RS20825	COG0275	rRNA processing
D1815_RS20835	COG0768	penicillin binding
D1815_RS20840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1815_RS20845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1815_RS20850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1815_RS20855	COG0772	Belongs to the SEDS family
D1815_RS20860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1815_RS20865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1815_RS20880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1815_RS20885	COG1610	YqeY-like protein
D1815_RS20960	COG3275	phosphorelay sensor kinase activity
D1815_RS20965	COG3279	Response regulator of the LytR AlgR family
D1815_RS20990	COG2244	polysaccharide biosynthetic process
D1815_RS20995	COG0438	transferase activity, transferring glycosyl groups
D1815_RS21060	COG2936	dipeptidyl-peptidase activity
D1815_RS21070	COG0598	Magnesium transport protein CorA
D1815_RS21085	COG0589	response to stress
D1815_RS21090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1815_RS21105	COG0730	response to heat
D1815_RS21110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1815_RS21110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1815_RS21140	COG2391	methyltransferase activity
D1815_RS21150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1815_RS21180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1815_RS21220	COG0589	response to stress
D1815_RS21225	COG2217	Heavy metal translocating P-type atpase
D1815_RS21230	COG0259	pyridoxamine-phosphate oxidase activity
D1815_RS21270	COG1595	DNA-templated transcription, initiation
D1815_RS21275	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1815_RS21315	COG0726	polysaccharide deacetylase
D1815_RS21370	COG0384	phenazine biosynthesis protein PhzF
D1815_RS21375	COG1595	DNA-templated transcription, initiation
D1815_RS21435	COG3278	Belongs to the heme-copper respiratory oxidase family
D1815_RS21445	COG2010	Cytochrome c
D1815_RS21465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1815_RS21485	COG1994	Peptidase M50
D1815_RS21515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D1815_RS21520	COG0813	purine-nucleoside phosphorylase activity
D1815_RS21525	COG0589	response to stress
D1815_RS21530	COG1254	Belongs to the acylphosphatase family
D1815_RS21570	COG1127	ABC transporter
D1815_RS21575	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1815_RS21600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1815_RS21600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1815_RS21610	COG0670	Belongs to the BI1 family
D1815_RS21620	COG0492	ferredoxin-NADP+ reductase activity
D1815_RS21625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1815_RS21645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1815_RS21690	COG1185	polyribonucleotide nucleotidyltransferase activity
D1815_RS21695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1815_RS21705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1815_RS21710	COG0191	fructose-bisphosphate aldolase activity
D1815_RS21730	COG2226	methyltransferase
D1815_RS21735	COG1073	alpha beta
D1815_RS21745	COG0569	domain protein
D1815_RS21750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1815_RS21760	COG0436	Aminotransferase
D1815_RS21765	COG3239	Fatty acid desaturase
D1815_RS21770	COG0357	Ribosomal RNA small subunit methyltransferase G
D1815_RS21785	COG1012	belongs to the aldehyde dehydrogenase family
D1815_RS21815	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1815_RS21820	COG1805	sodium ion transport
D1815_RS21825	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1815_RS21830	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1815_RS21835	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1815_RS21870	COG2197	response regulator
D1815_RS21895	COG1477	protein flavinylation
D1815_RS21900	COG3279	Response regulator of the LytR AlgR family
D1815_RS21905	COG3275	phosphorelay sensor kinase activity
D1815_RS21925	COG2226	methyltransferase
D1815_RS21950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D1815_RS21960	COG0501	Belongs to the peptidase M48B family
D1815_RS22005	COG2226	methyltransferase
D1815_RS22035	COG0463	Glycosyl transferase, family 2
D1815_RS22045	COG2066	Belongs to the glutaminase family
D1815_RS22050	COG3340	Belongs to the peptidase S51 family
D1815_RS22075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1815_RS22080	COG1404	Belongs to the peptidase S8 family
D1815_RS22090	COG3844	kynureninase activity
D1815_RS22095	COG2207	Transcriptional regulator
D1815_RS22135	COG0492	ferredoxin-NADP+ reductase activity
D1815_RS22140	COG0656	L-ascorbic acid biosynthetic process
D1815_RS22145	COG4191	Histidine kinase
D1815_RS22145	COG4191	Histidine kinase
D1815_RS22150	COG0588	phosphoglycerate mutase activity
D1815_RS22155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1815_RS22160	COG1012	belongs to the aldehyde dehydrogenase family
D1815_RS22175	COG1187	pseudouridine synthase activity
D1815_RS22185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1815_RS22185	COG0662	Cupin 2, conserved barrel domain protein
D1815_RS22195	COG0433	COG0433 Predicted ATPase
D1815_RS22200	COG0251	oxidation-reduction process
D1815_RS22205	COG0602	queuosine metabolic process
D1815_RS22215	COG0367	asparagine synthase
D1815_RS22230	COG0187	DNA topoisomerase II activity
D1815_RS22255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1815_RS22270	COG4452	Inner membrane protein CreD
D1815_RS22300	COG4206	TonB-dependent receptor
D1815_RS22300	COG1629	transport
D1815_RS22310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D1815_RS22315	COG1217	gtp-binding protein TYPA
D1815_RS22345	COG0438	transferase activity, transferring glycosyl groups
D1815_RS22355	COG1216	Glycosyl transferase, family 2
D1815_RS22355	COG0463	Glycosyl transferase, family 2
D1815_RS22375	COG2884	Cell division ATP-binding protein ftsE
D1815_RS22400	COG0739	heme binding
D1815_RS22435	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D1815_RS22505	COG2197	response regulator
D1815_RS22510	COG4585	Histidine kinase
D1815_RS22515	COG3876	Protein conserved in bacteria
D1815_RS22530	COG2207	Transcriptional regulator
D1815_RS22550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1815_RS22555	COG1115	amino acid carrier protein
D1815_RS22565	COG1960	acyl-CoA dehydrogenase activity
D1815_RS22580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1815_RS22585	COG4974	Belongs to the 'phage' integrase family
D1815_RS22615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1815_RS22635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1815_RS22640	COG0081	regulation of translation
D1815_RS22645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1815_RS22650	COG0222	ribosome binding
D1815_RS22655	COG0085	RNA polymerase activity
D1815_RS22660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1815_RS22675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D1815_RS22690	COG2885	chlorophyll binding
D1815_RS22695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1815_RS22705	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1815_RS22710	COG1482	cell wall glycoprotein biosynthetic process
D1815_RS22745	COG0561	phosphatase activity
D1815_RS22825	COG2197	response regulator
D1815_RS22830	COG0326	Molecular chaperone. Has ATPase activity
D1815_RS22850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1815_RS22865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1815_RS22870	COG0577	efflux transmembrane transporter activity
D1815_RS22870	COG1136	(ABC) transporter
D1815_RS22880	COG0488	(ABC) transporter
D1815_RS22890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1815_RS22900	COG1183	phosphatidylcholine synthase activity
D1815_RS22915	COG2843	Capsule synthesis protein
D1815_RS22920	COG1137	ATPase activity
D1815_RS22930	COG0805	protein transport
D1815_RS22935	COG0517	IMP dehydrogenase activity
D1815_RS22935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1815_RS22940	COG0514	ATP-dependent DNA helicase (RecQ)
D1815_RS22975	COG3275	phosphorelay sensor kinase activity
D1815_RS23000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1815_RS23045	COG1132	(ABC) transporter
D1815_RS23055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1815_RS23065	COG1862	Preprotein translocase
D1815_RS23070	COG0668	transmembrane transport
D1815_RS23075	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1815_RS23085	COG4771	TonB-dependent receptor
D1815_RS23110	COG0167	dihydroorotate dehydrogenase activity
D1815_RS23160	COG0793	Belongs to the peptidase S41A family
D1815_RS23160	COG4946	Tricorn protease homolog
D1815_RS23185	COG0071	Belongs to the small heat shock protein (HSP20) family
D1815_RS23205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1815_RS23210	COG3279	Response regulator of the LytR AlgR family
D1815_RS23255	COG0259	pyridoxamine-phosphate oxidase activity
D1815_RS23260	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1815_RS23285	COG1131	(ABC) transporter
D1815_RS23315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1815_RS23315	COG0617	tRNA 3'-terminal CCA addition
D1815_RS23315	COG0517	IMP dehydrogenase activity
D1815_RS23320	COG0009	L-threonylcarbamoyladenylate synthase
D1815_RS23325	COG0438	transferase activity, transferring glycosyl groups
D1815_RS23355	COG3275	phosphorelay sensor kinase activity
D1815_RS23385	COG2171	N-acyltransferase activity
D1815_RS23390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1815_RS23395	COG0242	peptide deformylase activity
D1815_RS23405	COG0504	CTP synthase activity
D1815_RS23410	COG0706	membrane insertase activity
D1815_RS23415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1815_RS23425	COG0482	sulfurtransferase activity
D1815_RS23440	COG3956	TIGRFAM MazG family protein
D1815_RS23455	COG4771	TonB-dependent receptor
D1815_RS23465	COG1629	transport
D1815_RS23475	COG1874	Beta-galactosidase
D1815_RS23475	COG0366	Alpha amylase catalytic
D1815_RS23490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)