locus-tag	class	description
D1816_RS00015	COG0513	Belongs to the DEAD box helicase family
D1816_RS00030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1816_RS00040	COG0037	tRNA processing
D1816_RS00100	COG4206	TonB-dependent receptor
D1816_RS00100	COG1629	transport
D1816_RS00120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1816_RS00125	COG1554	hydrolase, family 65, central catalytic
D1816_RS00130	COG0366	Alpha amylase catalytic
D1816_RS00140	COG0205	6-phosphofructokinase activity
D1816_RS00170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1816_RS00180	COG2197	response regulator
D1816_RS00190	COG1116	anion transmembrane transporter activity
D1816_RS00190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1816_RS00195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1816_RS00200	COG1116	anion transmembrane transporter activity
D1816_RS00200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1816_RS00205	COG1116	anion transmembrane transporter activity
D1816_RS00210	COG2223	nitrite transmembrane transporter activity
D1816_RS00215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1816_RS00215	COG1333	cytochrome c biogenesis protein
D1816_RS00220	COG1333	cytochrome c biogenesis protein
D1816_RS00220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1816_RS00235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1816_RS00255	COG0243	molybdopterin cofactor binding
D1816_RS00280	COG3409	Peptidoglycan-binding domain 1 protein
D1816_RS00280	COG0793	Belongs to the peptidase S41A family
D1816_RS00290	COG0784	Response regulator, receiver
D1816_RS00290	COG5002	protein histidine kinase activity
D1816_RS00290	COG2198	Histidine kinase
D1816_RS00305	COG5654	RES domain protein
D1816_RS00310	COG3590	peptidase
D1816_RS00320	COG0527	aspartate kinase activity
D1816_RS00350	COG0612	Peptidase, M16
D1816_RS00360	COG1914	H( )-stimulated, divalent metal cation uptake system
D1816_RS00370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1816_RS00390	COG4585	Histidine kinase
D1816_RS00395	COG2197	response regulator
D1816_RS00400	COG0129	dihydroxy-acid dehydratase activity
D1816_RS00405	COG0028	Belongs to the TPP enzyme family
D1816_RS00415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1816_RS00420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1816_RS00430	COG0800	Aldolase
D1816_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS00445	COG2271	Major facilitator Superfamily
D1816_RS00450	COG2186	Transcriptional regulator
D1816_RS00465	COG0702	epimerase
D1816_RS00470	COG1629	transport
D1816_RS00510	COG0137	argininosuccinate synthase activity
D1816_RS00515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1816_RS00520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1816_RS00525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1816_RS00535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1816_RS00540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1816_RS00545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1816_RS00555	COG0165	Argininosuccinate lyase
D1816_RS00560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1816_RS00595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1816_RS00605	COG5002	protein histidine kinase activity
D1816_RS00610	COG0745	RESPONSE REGULATOR receiver
D1816_RS00620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1816_RS00625	COG2318	DinB family
D1816_RS00630	COG0488	(ABC) transporter
D1816_RS00650	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D1816_RS00670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1816_RS00675	COG0439	Biotin carboxylase
D1816_RS00680	COG4770	biotin carboxylase activity
D1816_RS00720	COG4251	negative regulation of phosphorylation
D1816_RS00735	COG0673	inositol 2-dehydrogenase activity
D1816_RS00740	COG2211	Major facilitator Superfamily
D1816_RS00765	COG2207	Transcriptional regulator
D1816_RS00770	COG2319	Wd-40 repeat
D1816_RS00780	COG0006	proline dipeptidase activity
D1816_RS00805	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1816_RS00810	COG2205	protein histidine kinase activity
D1816_RS00810	COG3292	Two component regulator propeller
D1816_RS00810	COG0745	RESPONSE REGULATOR receiver
D1816_RS00840	COG1063	alcohol dehydrogenase
D1816_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS00855	COG4948	Mandelate Racemase Muconate Lactonizing
D1816_RS00865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D1816_RS00875	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1816_RS00890	COG4585	Histidine kinase
D1816_RS00930	COG0302	gtp cyclohydrolase
D1816_RS00940	COG1136	(ABC) transporter
D1816_RS00955	COG0737	Belongs to the 5'-nucleotidase family
D1816_RS00960	COG0737	Belongs to the 5'-nucleotidase family
D1816_RS00965	COG0523	cobalamin synthesis protein
D1816_RS01015	COG1166	arginine decarboxylase activity
D1816_RS01020	COG0010	Belongs to the arginase family
D1816_RS01040	COG4067	protein conserved in archaea
D1816_RS01040	COG0189	ligase activity
D1816_RS01055	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D1816_RS01070	COG0004	ammonium transporteR
D1816_RS01080	COG0067	glutamate synthase
D1816_RS01080	COG0070	glutamate synthase
D1816_RS01080	COG0069	glutamate synthase activity
D1816_RS01110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1816_RS01125	COG0673	inositol 2-dehydrogenase activity
D1816_RS01140	COG0592	DNA-directed DNA polymerase activity
D1816_RS01150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1816_RS01165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1816_RS01175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1816_RS01185	COG4206	TonB-dependent receptor
D1816_RS01235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1816_RS01270	COG2885	chlorophyll binding
D1816_RS01275	COG0668	transmembrane transport
D1816_RS01295	COG0513	Belongs to the DEAD box helicase family
D1816_RS01310	COG0300	oxidoreductase activity
D1816_RS01315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1816_RS01325	COG0488	(ABC) transporter
D1816_RS01415	COG0473	3-isopropylmalate dehydrogenase activity
D1816_RS01420	COG0066	3-isopropylmalate dehydratase activity
D1816_RS01425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1816_RS01430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1816_RS01460	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1816_RS01470	COG1760	l-serine dehydratase
D1816_RS01475	COG0443	Heat shock 70 kDa protein
D1816_RS01485	COG0405	Gamma-glutamyltransferase
D1816_RS01490	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D1816_RS01500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1816_RS01520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1816_RS01525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D1816_RS01550	COG1560	Kdo2-lipid A biosynthetic process
D1816_RS01560	COG0705	Rhomboid family
D1816_RS01565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS01590	COG0783	Belongs to the Dps family
D1816_RS01595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1816_RS01600	COG1363	Peptidase, m42
D1816_RS01635	COG1272	protein, Hemolysin III
D1816_RS01645	COG2205	protein histidine kinase activity
D1816_RS01645	COG0784	Response regulator, receiver
D1816_RS01665	COG0116	Belongs to the methyltransferase superfamily
D1816_RS01680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1816_RS01685	COG1595	DNA-templated transcription, initiation
D1816_RS01695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1816_RS01745	COG1104	cysteine desulfurase activity
D1816_RS01755	COG0739	heme binding
D1816_RS01760	COG0438	transferase activity, transferring glycosyl groups
D1816_RS01765	COG0562	UDP-galactopyranose mutase
D1816_RS01785	COG1418	mRNA catabolic process
D1816_RS01800	COG0542	response to heat
D1816_RS01855	COG0280	phosphate acetyltransferase
D1816_RS01855	COG0857	belongs to the CobB CobQ family
D1816_RS01860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1816_RS01885	COG5297	Belongs to the glycosyl hydrolase family 6
D1816_RS01885	COG4733	cellulase activity
D1816_RS01915	COG0640	Transcriptional regulator
D1816_RS01925	COG0735	belongs to the Fur family
D1816_RS01940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1816_RS01960	COG1881	PFAM PEBP family protein
D1816_RS01980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1816_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS02045	COG1942	4-Oxalocrotonate Tautomerase
D1816_RS02105	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1816_RS02160	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1816_RS02195	COG3708	Transcriptional regulator
D1816_RS02195	COG2207	Transcriptional regulator
D1816_RS02560	COG1401	restriction endodeoxyribonuclease activity
D1816_RS02600	COG2329	Antibiotic biosynthesis monooxygenase
D1816_RS02680	COG4974	Belongs to the 'phage' integrase family
D1816_RS02700	COG2205	protein histidine kinase activity
D1816_RS02705	COG3279	Response regulator of the LytR AlgR family
D1816_RS02715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1816_RS02720	COG0308	aminopeptidase N
D1816_RS02760	COG0069	glutamate synthase activity
D1816_RS02765	COG1473	amidohydrolase
D1816_RS02790	COG0009	L-threonylcarbamoyladenylate synthase
D1816_RS02795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1816_RS02795	COG2207	Transcriptional regulator
D1816_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS02850	COG1629	transport
D1816_RS02855	COG0561	phosphatase activity
D1816_RS02905	COG1393	Belongs to the ArsC family
D1816_RS02995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1816_RS03010	COG0156	8-amino-7-oxononanoate synthase activity
D1816_RS03090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1816_RS03100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1816_RS03105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1816_RS03120	COG0321	lipoyl(octanoyl) transferase activity
D1816_RS03120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D1816_RS03135	COG1501	Belongs to the glycosyl hydrolase 31 family
D1816_RS03210	COG0513	Belongs to the DEAD box helicase family
D1816_RS03230	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D1816_RS03235	COG4251	negative regulation of phosphorylation
D1816_RS03245	COG1858	cytochrome C peroxidase
D1816_RS03255	COG1136	(ABC) transporter
D1816_RS03265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1816_RS03270	COG0302	gtp cyclohydrolase
D1816_RS03315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1816_RS03320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1816_RS03330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1816_RS03345	COG1073	alpha beta
D1816_RS03355	COG0366	Alpha amylase catalytic
D1816_RS03360	COG1575	Belongs to the MenA family. Type 1 subfamily
D1816_RS03365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1816_RS03415	COG3279	Response regulator of the LytR AlgR family
D1816_RS03420	COG3275	phosphorelay sensor kinase activity
D1816_RS03425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1816_RS03445	COG0488	(ABC) transporter
D1816_RS03465	COG1187	pseudouridine synthase activity
D1816_RS03470	COG1278	Cold shock
D1816_RS03475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1816_RS03520	COG3279	Response regulator of the LytR AlgR family
D1816_RS03545	COG3292	Two component regulator propeller
D1816_RS03545	COG2205	protein histidine kinase activity
D1816_RS03545	COG0745	RESPONSE REGULATOR receiver
D1816_RS03585	COG4206	TonB-dependent receptor
D1816_RS03585	COG1629	transport
D1816_RS03590	COG1629	transport
D1816_RS03610	COG3012	SEC-C Motif Domain Protein
D1816_RS03620	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1816_RS03655	COG1741	Belongs to the pirin family
D1816_RS03665	COG2378	regulation of single-species biofilm formation
D1816_RS03680	COG0297	glycogen (starch) synthase activity
D1816_RS03685	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1816_RS03690	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1816_RS03695	COG3387	PFAM Glycoside hydrolase 15-related
D1816_RS03700	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D1816_RS03750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1816_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS03775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1816_RS03785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1816_RS03790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1816_RS03820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1816_RS03820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1816_RS03825	COG1054	Belongs to the UPF0176 family
D1816_RS03835	COG0450	alkyl hydroperoxide reductase
D1816_RS03870	COG2814	Major facilitator Superfamily
D1816_RS03920	COG0778	Nitroreductase
D1816_RS03925	COG1733	regulation of RNA biosynthetic process
D1816_RS03935	COG0300	oxidoreductase activity
D1816_RS03945	COG1024	Enoyl-CoA hydratase
D1816_RS03970	COG3275	phosphorelay sensor kinase activity
D1816_RS04050	COG3279	Response regulator of the LytR AlgR family
D1816_RS04055	COG3275	phosphorelay sensor kinase activity
D1816_RS04075	COG3279	Response regulator of the LytR AlgR family
D1816_RS04095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1816_RS04105	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D1816_RS04135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1816_RS04155	COG1999	signal sequence binding
D1816_RS04255	COG4977	sequence-specific DNA binding
D1816_RS04255	COG1917	Cupin 2, conserved barrel domain protein
D1816_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS04285	COG0739	heme binding
D1816_RS04295	COG3279	Response regulator of the LytR AlgR family
D1816_RS04350	COG3279	Response regulator of the LytR AlgR family
D1816_RS04390	COG1794	racemase activity, acting on amino acids and derivatives
D1816_RS04395	COG0583	DNA-binding transcription factor activity
D1816_RS04405	COG1595	DNA-templated transcription, initiation
D1816_RS04455	COG1595	DNA-templated transcription, initiation
D1816_RS04490	COG1131	(ABC) transporter
D1816_RS04495	COG3275	phosphorelay sensor kinase activity
D1816_RS04500	COG3279	Response regulator of the LytR AlgR family
D1816_RS04515	COG1404	Belongs to the peptidase S8 family
D1816_RS04540	COG3011	Protein conserved in bacteria
D1816_RS04545	COG1132	(ABC) transporter
D1816_RS04555	COG3279	Response regulator of the LytR AlgR family
D1816_RS04560	COG3275	phosphorelay sensor kinase activity
D1816_RS04570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D1816_RS04580	COG1573	uracil-dna glycosylase
D1816_RS04600	COG1278	Cold shock
D1816_RS04705	COG3279	Response regulator of the LytR AlgR family
D1816_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS04715	COG1012	belongs to the aldehyde dehydrogenase family
D1816_RS04895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1816_RS04900	COG0640	Transcriptional regulator
D1816_RS04910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1816_RS04925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1816_RS04935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1816_RS04960	COG4974	Belongs to the 'phage' integrase family
D1816_RS04980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1816_RS04990	COG0083	homoserine kinase activity
D1816_RS05000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1816_RS05015	COG0189	ligase activity
D1816_RS05040	COG4946	Tricorn protease homolog
D1816_RS05040	COG0823	Involved in the tonB-independent uptake of proteins
D1816_RS05040	COG1506	peptidase
D1816_RS05055	COG4771	TonB-dependent receptor
D1816_RS05075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1816_RS05085	COG3011	Protein conserved in bacteria
D1816_RS05095	COG4771	TonB-dependent receptor
D1816_RS05105	COG0076	glutamate decarboxylase activity
D1816_RS05110	COG0583	DNA-binding transcription factor activity
D1816_RS05120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1816_RS05125	COG2610	gluconate transmembrane transporter activity
D1816_RS05140	COG2273	Hydrolase Family 16
D1816_RS05160	COG0277	FAD linked oxidase domain protein
D1816_RS05180	COG0438	transferase activity, transferring glycosyl groups
D1816_RS05190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1816_RS05220	COG0318	PFAM AMP-dependent synthetase and ligase
D1816_RS05250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1816_RS05270	COG0259	pyridoxamine-phosphate oxidase activity
D1816_RS05280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS05290	COG0540	Belongs to the ATCase OTCase family
D1816_RS05295	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1816_RS05300	COG0539	negative regulation of cytoplasmic translation
D1816_RS05325	COG0140	phosphoribosyl-ATP diphosphatase activity
D1816_RS05325	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1816_RS05330	COG0107	imidazoleglycerol-phosphate synthase activity
D1816_RS05340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1816_RS05350	COG0131	Imidazoleglycerol-phosphate dehydratase
D1816_RS05355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1816_RS05360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1816_RS05370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1816_RS05380	COG3743	rRNA binding
D1816_RS05380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1816_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS05405	COG0612	Peptidase, M16
D1816_RS05410	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D1816_RS05420	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1816_RS05425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1816_RS05430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1816_RS05435	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D1816_RS05435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1816_RS05440	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1816_RS05445	COG1078	dGTPase activity
D1816_RS05450	COG2204	response regulator
D1816_RS05455	COG0802	atpase or kinase
D1816_RS05475	COG3813	Protein conserved in bacteria
D1816_RS05490	COG1629	transport
D1816_RS05495	COG0702	epimerase
D1816_RS05525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1816_RS05535	COG0471	metal ion transport
D1816_RS05550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1816_RS05555	COG1611	Belongs to the LOG family
D1816_RS05595	COG2996	Protein conserved in bacteria
D1816_RS05605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D1816_RS05610	COG1169	isochorismate synthase
D1816_RS05655	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1816_RS05660	COG1522	sequence-specific DNA binding
D1816_RS05680	COG0861	Integral membrane protein TerC family
D1816_RS05690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1816_RS05695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS05730	COG1064	alcohol dehydrogenase
D1816_RS05745	COG2267	carboxylic ester hydrolase activity
D1816_RS05750	COG0784	Response regulator, receiver
D1816_RS05750	COG5002	protein histidine kinase activity
D1816_RS05750	COG2198	Histidine kinase
D1816_RS05760	COG0012	GTP binding
D1816_RS05770	COG4771	TonB-dependent receptor
D1816_RS05775	COG4771	TonB-dependent receptor
D1816_RS05780	COG0668	transmembrane transport
D1816_RS05790	COG1480	7TM receptor with intracellular HD hydrolase
D1816_RS05795	COG0183	Belongs to the thiolase family
D1816_RS05800	COG0791	NLP P60 protein
D1816_RS05830	COG0456	acetyltransferase
D1816_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS05845	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS05855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1816_RS05865	COG1045	serine acetyltransferase
D1816_RS05875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1816_RS05895	COG2258	MOSC domain
D1816_RS05905	COG1652	LysM domain
D1816_RS05905	COG2823	Periplasmic or secreted lipoprotein
D1816_RS05915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1816_RS05925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1816_RS05970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1816_RS05975	COG1696	Membrane protein involved in D-alanine export
D1816_RS06000	COG1045	serine acetyltransferase
D1816_RS06005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1816_RS06025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1816_RS06055	COG1696	Membrane protein involved in D-alanine export
D1816_RS06065	COG0438	transferase activity, transferring glycosyl groups
D1816_RS06070	COG0463	Glycosyl transferase, family 2
D1816_RS06070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1816_RS06105	COG0438	transferase activity, transferring glycosyl groups
D1816_RS06110	COG0438	transferase activity, transferring glycosyl groups
D1816_RS06130	COG1696	Membrane protein involved in D-alanine export
D1816_RS06140	COG1216	Glycosyl transferase, family 2
D1816_RS06155	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1816_RS06160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1816_RS06165	COG0022	dehydrogenase e1 component
D1816_RS06185	COG0813	purine-nucleoside phosphorylase activity
D1816_RS06200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1816_RS06205	COG1193	negative regulation of DNA recombination
D1816_RS06220	COG0673	inositol 2-dehydrogenase activity
D1816_RS06230	COG1476	TRANSCRIPTIONal
D1816_RS06240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1816_RS06260	COG0415	Belongs to the DNA photolyase family
D1816_RS06275	COG0583	DNA-binding transcription factor activity
D1816_RS06280	COG2986	histidine ammonia-lyase
D1816_RS06290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1816_RS06295	COG0010	Belongs to the arginase family
D1816_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS06320	COG0604	alcohol dehydrogenase
D1816_RS06325	COG2130	NADP-dependent
D1816_RS06330	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS06345	COG1960	acyl-CoA dehydrogenase activity
D1816_RS06350	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS06355	COG1960	acyl-CoA dehydrogenase activity
D1816_RS06365	COG2205	protein histidine kinase activity
D1816_RS06365	COG3850	Histidine kinase
D1816_RS06365	COG4999	Histidine kinase
D1816_RS06365	COG3437	response regulator, receiver
D1816_RS06370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1816_RS06390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1816_RS06395	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1816_RS06395	COG2010	Cytochrome c
D1816_RS06410	COG0514	ATP-dependent DNA helicase (RecQ)
D1816_RS06415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1816_RS06425	COG1678	Uncharacterized ACR, COG1678
D1816_RS06470	COG0124	histidyl-tRNA synthetase
D1816_RS06475	COG0577	efflux transmembrane transporter activity
D1816_RS06495	COG0359	binds to the 23S rRNA
D1816_RS06500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1816_RS06505	COG0360	Binds together with S18 to 16S ribosomal RNA
D1816_RS06510	COG3279	Response regulator of the LytR AlgR family
D1816_RS06515	COG3279	Response regulator of the LytR AlgR family
D1816_RS06520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1816_RS06545	COG1295	ribonuclease BN
D1816_RS06555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1816_RS06565	COG0424	maF-like protein
D1816_RS06580	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1816_RS06585	COG0217	transcriptional regulatory protein
D1816_RS06605	COG1454	alcohol dehydrogenase
D1816_RS06610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1816_RS06635	COG4989	oxidoreductase activity
D1816_RS06640	COG1472	Belongs to the glycosyl hydrolase 3 family
D1816_RS06650	COG0247	lactate metabolic process
D1816_RS06650	COG2181	nitrate reductase activity
D1816_RS06660	COG2181	nitrate reductase activity
D1816_RS06660	COG0247	lactate metabolic process
D1816_RS06665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1816_RS06670	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1816_RS06680	COG0251	oxidation-reduction process
D1816_RS06700	COG0205	6-phosphofructokinase activity
D1816_RS06710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1816_RS06730	COG0657	acetylesterase activity
D1816_RS06730	COG2755	lipolytic protein G-D-S-L family
D1816_RS06770	COG2015	COG2015, Alkyl sulfatase and related hydrolases
D1816_RS06785	COG0251	oxidation-reduction process
D1816_RS06795	COG3119	arylsulfatase activity
D1816_RS06810	COG0702	epimerase
D1816_RS06835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1816_RS06860	COG0628	permease
D1816_RS06915	COG2885	chlorophyll binding
D1816_RS06945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1816_RS06945	COG1333	cytochrome c biogenesis protein
D1816_RS06960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1816_RS06970	COG1757	Na H antiporter
D1816_RS06980	COG0778	Nitroreductase
D1816_RS06985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1816_RS06990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1816_RS06990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1816_RS07005	COG1674	ftsk spoiiie
D1816_RS07015	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D1816_RS07030	COG0450	alkyl hydroperoxide reductase
D1816_RS07040	COG0626	cystathionine gamma-synthase activity
D1816_RS07045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1816_RS07055	COG2234	aminopeptidase activity
D1816_RS07070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1816_RS07090	COG1917	Cupin 2, conserved barrel domain protein
D1816_RS07090	COG2169	Transcriptional regulator
D1816_RS07100	COG2207	Transcriptional regulator
D1816_RS07100	COG1917	Cupin 2, conserved barrel domain protein
D1816_RS07120	COG3142	Participates in the control of copper homeostasis
D1816_RS07145	COG1629	transport
D1816_RS07185	COG1446	asparaginase
D1816_RS07190	COG3537	Alpha-1,2-mannosidase
D1816_RS07205	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
D1816_RS07215	COG3537	Alpha-1,2-mannosidase
D1816_RS07225	COG3279	Response regulator of the LytR AlgR family
D1816_RS07230	COG0784	Response regulator, receiver
D1816_RS07230	COG2205	protein histidine kinase activity
D1816_RS07235	COG0745	RESPONSE REGULATOR receiver
D1816_RS07260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1816_RS07265	COG1702	phosphate starvation-inducible protein PhoH
D1816_RS07285	COG1120	ATPase activity
D1816_RS07295	COG1322	Protein conserved in bacteria
D1816_RS07315	COG1607	acyl-coa hydrolase
D1816_RS07325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1816_RS07330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1816_RS07365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1816_RS07370	COG4166	transmembrane transport
D1816_RS07385	COG0254	rRNA binding
D1816_RS07425	COG0463	Glycosyl transferase, family 2
D1816_RS07430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1816_RS07435	COG1132	(ABC) transporter
D1816_RS07440	COG1595	DNA-templated transcription, initiation
D1816_RS07460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1816_RS07460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1816_RS07470	COG0047	phosphoribosylformylglycinamidine synthase activity
D1816_RS07470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1816_RS07480	COG1022	Amp-dependent synthetase and ligase
D1816_RS07485	COG1846	Transcriptional regulator
D1816_RS07490	COG1024	Enoyl-CoA hydratase
D1816_RS07490	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1816_RS07495	COG0183	Belongs to the thiolase family
D1816_RS07500	COG1960	acyl-CoA dehydrogenase activity
D1816_RS07545	COG4206	TonB-dependent receptor
D1816_RS07545	COG1629	transport
D1816_RS07595	COG2234	aminopeptidase activity
D1816_RS07600	COG2819	hydrolase of the alpha beta superfamily
D1816_RS07605	COG1280	lysine exporter protein (LysE YggA)
D1816_RS07630	COG3275	phosphorelay sensor kinase activity
D1816_RS07640	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D1816_RS07645	COG0363	glucosamine-6-phosphate deaminase activity
D1816_RS07655	COG4771	TonB-dependent receptor
D1816_RS07660	COG3279	Response regulator of the LytR AlgR family
D1816_RS07665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1816_RS07735	COG0596	Alpha beta hydrolase
D1816_RS07785	COG2267	carboxylic ester hydrolase activity
D1816_RS07795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1816_RS07825	COG2205	protein histidine kinase activity
D1816_RS07825	COG3437	response regulator, receiver
D1816_RS07825	COG3850	Histidine kinase
D1816_RS07825	COG4999	Histidine kinase
D1816_RS07830	COG5002	protein histidine kinase activity
D1816_RS07830	COG0784	Response regulator, receiver
D1816_RS07830	COG2198	Histidine kinase
D1816_RS07865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1816_RS07885	COG1335	isochorismatase
D1816_RS07890	COG2267	carboxylic ester hydrolase activity
D1816_RS07910	COG3118	belongs to the thioredoxin family
D1816_RS07920	COG1959	2 iron, 2 sulfur cluster binding
D1816_RS07925	COG0596	Alpha beta hydrolase
D1816_RS07995	COG1595	DNA-templated transcription, initiation
D1816_RS08045	COG1191	sigma factor activity
D1816_RS08050	COG1252	NADH dehydrogenase
D1816_RS08080	COG3275	phosphorelay sensor kinase activity
D1816_RS08100	COG3279	Response regulator of the LytR AlgR family
D1816_RS08115	COG0494	nUDIX hydrolase
D1816_RS08120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1816_RS08150	COG0714	Associated with various cellular activities
D1816_RS08180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS08270	COG0492	ferredoxin-NADP+ reductase activity
D1816_RS08275	COG2860	membrane
D1816_RS08285	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1816_RS08325	COG4771	TonB-dependent receptor
D1816_RS08360	COG0587	DNA-directed DNA polymerase activity
D1816_RS08370	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D1816_RS08390	COG3279	Response regulator of the LytR AlgR family
D1816_RS08440	COG1271	oxidase subunit
D1816_RS08470	COG0366	Alpha amylase catalytic
D1816_RS08510	COG0542	response to heat
D1816_RS08645	COG0791	NLP P60 protein
D1816_RS08650	COG0791	NLP P60 protein
D1816_RS08690	COG2273	Hydrolase Family 16
D1816_RS08730	COG0668	transmembrane transport
D1816_RS08740	COG3279	Response regulator of the LytR AlgR family
D1816_RS08765	COG2133	pyrroloquinoline quinone binding
D1816_RS08770	COG2010	Cytochrome c
D1816_RS08780	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1816_RS08785	COG0572	uridine kinase
D1816_RS08795	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1816_RS08805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1816_RS08805	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1816_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS08815	COG1192	Involved in chromosome partitioning
D1816_RS08820	COG1475	DNA binding
D1816_RS08830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1816_RS08835	COG0681	Belongs to the peptidase S26 family
D1816_RS08870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D1816_RS08880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1816_RS08890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1816_RS08920	COG1595	DNA-templated transcription, initiation
D1816_RS08925	COG3712	iron ion homeostasis
D1816_RS08935	COG0105	UTP biosynthetic process
D1816_RS08945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1816_RS08955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1816_RS08960	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1816_RS08990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1816_RS09005	COG0305	Participates in initiation and elongation during chromosome replication
D1816_RS09010	COG0825	malonyl-CoA metabolic process
D1816_RS09025	COG0343	queuine tRNA-ribosyltransferase activity
D1816_RS09030	COG3959	Transketolase, thiamine diphosphate binding domain
D1816_RS09035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1816_RS09055	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1816_RS09060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1816_RS09065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1816_RS09115	COG3250	beta-galactosidase activity
D1816_RS09120	COG2207	Transcriptional regulator
D1816_RS09135	COG2124	cytochrome p450
D1816_RS09140	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1816_RS09145	COG2115	Belongs to the xylose isomerase family
D1816_RS09150	COG0745	RESPONSE REGULATOR receiver
D1816_RS09150	COG3292	Two component regulator propeller
D1816_RS09150	COG2205	protein histidine kinase activity
D1816_RS09155	COG1082	Xylose isomerase domain protein TIM barrel
D1816_RS09165	COG3250	beta-galactosidase activity
D1816_RS09170	COG3119	arylsulfatase activity
D1816_RS09180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1816_RS09185	COG4771	TonB-dependent receptor
D1816_RS09190	COG0561	phosphatase activity
D1816_RS09215	COG1472	Belongs to the glycosyl hydrolase 3 family
D1816_RS09225	COG2273	Hydrolase Family 16
D1816_RS09225	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D1816_RS09230	COG3507	Belongs to the glycosyl hydrolase 43 family
D1816_RS09250	COG3119	arylsulfatase activity
D1816_RS09255	COG3119	arylsulfatase activity
D1816_RS09260	COG3250	beta-galactosidase activity
D1816_RS09265	COG3119	arylsulfatase activity
D1816_RS09275	COG3250	beta-galactosidase activity
D1816_RS09280	COG2755	lipolytic protein G-D-S-L family
D1816_RS09280	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1816_RS09290	COG3401	FG-GAP repeat protein
D1816_RS09315	COG1063	alcohol dehydrogenase
D1816_RS09330	COG2721	sulfolactate sulfo-lyase activity
D1816_RS09335	COG0246	Mannitol dehydrogenase
D1816_RS09345	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS09350	COG0738	Major facilitator superfamily
D1816_RS09355	COG3254	rhamnose metabolic process
D1816_RS09360	COG3119	arylsulfatase activity
D1816_RS09370	COG3250	beta-galactosidase activity
D1816_RS09395	COG1917	Cupin 2, conserved barrel domain protein
D1816_RS09395	COG2207	Transcriptional regulator
D1816_RS09420	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D1816_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS09510	COG3279	Response regulator of the LytR AlgR family
D1816_RS09520	COG3119	arylsulfatase activity
D1816_RS09530	COG3292	Two component regulator propeller
D1816_RS09530	COG2205	protein histidine kinase activity
D1816_RS09530	COG0745	RESPONSE REGULATOR receiver
D1816_RS09535	COG3250	beta-galactosidase activity
D1816_RS09550	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D1816_RS09575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS09605	COG0714	Associated with various cellular activities
D1816_RS09610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1816_RS09620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1816_RS09640	COG0517	IMP dehydrogenase activity
D1816_RS09640	COG0516	GMP reductase activity
D1816_RS09645	COG0671	phosphoesterase, PA-phosphatase related
D1816_RS09710	COG1528	Iron-storage protein
D1816_RS09750	COG0745	RESPONSE REGULATOR receiver
D1816_RS09750	COG2972	Histidine kinase
D1816_RS09770	COG0167	dihydroorotate dehydrogenase activity
D1816_RS09775	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1816_RS09785	COG1862	Preprotein translocase
D1816_RS09795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1816_RS09805	COG1132	(ABC) transporter
D1816_RS09840	COG2318	DinB family
D1816_RS09850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1816_RS09860	COG0514	ATP-dependent DNA helicase (RecQ)
D1816_RS09865	COG0517	IMP dehydrogenase activity
D1816_RS09865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1816_RS09870	COG0805	protein transport
D1816_RS09880	COG1137	ATPase activity
D1816_RS09885	COG1183	phosphatidylcholine synthase activity
D1816_RS09890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1816_RS09895	COG0488	(ABC) transporter
D1816_RS09905	COG0840	transmembrane signaling receptor activity
D1816_RS09910	COG1136	(ABC) transporter
D1816_RS09915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1816_RS09930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1816_RS09940	COG2197	response regulator
D1816_RS09945	COG4585	Histidine kinase
D1816_RS09960	COG0326	Molecular chaperone. Has ATPase activity
D1816_RS09965	COG2197	response regulator
D1816_RS10020	COG0823	Involved in the tonB-independent uptake of proteins
D1816_RS10020	COG4946	Tricorn protease homolog
D1816_RS10020	COG1506	peptidase
D1816_RS10025	COG0561	phosphatase activity
D1816_RS10065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1816_RS10075	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1816_RS10095	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D1816_RS10110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1816_RS10115	COG0085	RNA polymerase activity
D1816_RS10120	COG0222	ribosome binding
D1816_RS10125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1816_RS10130	COG0081	regulation of translation
D1816_RS10135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1816_RS10155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D1816_RS10185	COG4974	Belongs to the 'phage' integrase family
D1816_RS10190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1816_RS10200	COG1960	acyl-CoA dehydrogenase activity
D1816_RS10210	COG1115	amino acid carrier protein
D1816_RS10215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1816_RS10250	COG3876	Protein conserved in bacteria
D1816_RS10320	COG2884	Cell division ATP-binding protein ftsE
D1816_RS10325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1816_RS10335	COG1217	gtp-binding protein TYPA
D1816_RS10345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D1816_RS10360	COG0753	catalase activity
D1816_RS10395	COG4452	Inner membrane protein CreD
D1816_RS10415	COG1917	Cupin 2, conserved barrel domain protein
D1816_RS10415	COG2207	Transcriptional regulator
D1816_RS10425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1816_RS10445	COG0187	DNA topoisomerase II activity
D1816_RS10455	COG0367	asparagine synthase
D1816_RS10465	COG0602	queuosine metabolic process
D1816_RS10470	COG0251	oxidation-reduction process
D1816_RS10475	COG0433	COG0433 Predicted ATPase
D1816_RS10485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1816_RS10485	COG0662	Cupin 2, conserved barrel domain protein
D1816_RS10495	COG1187	pseudouridine synthase activity
D1816_RS10515	COG1012	belongs to the aldehyde dehydrogenase family
D1816_RS10520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1816_RS10535	COG4191	Histidine kinase
D1816_RS10535	COG4191	Histidine kinase
D1816_RS10540	COG0656	L-ascorbic acid biosynthetic process
D1816_RS10545	COG0492	ferredoxin-NADP+ reductase activity
D1816_RS10570	COG2211	Major facilitator Superfamily
D1816_RS10575	COG2723	6-phospho-beta-galactosidase activity
D1816_RS10590	COG1864	DNA RNA non-specific endonuclease
D1816_RS10590	COG3591	Belongs to the peptidase S1B family
D1816_RS10650	COG3844	kynureninase activity
D1816_RS10660	COG1404	Belongs to the peptidase S8 family
D1816_RS10665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1816_RS10690	COG3340	Belongs to the peptidase S51 family
D1816_RS10695	COG2066	Belongs to the glutaminase family
D1816_RS10785	COG0501	Belongs to the peptidase M48B family
D1816_RS10795	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D1816_RS10825	COG1477	protein flavinylation
D1816_RS10850	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1816_RS10860	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1816_RS10865	COG1805	sodium ion transport
D1816_RS10870	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1816_RS10900	COG1012	belongs to the aldehyde dehydrogenase family
D1816_RS10940	COG0357	Ribosomal RNA small subunit methyltransferase G
D1816_RS10945	COG3239	Fatty acid desaturase
D1816_RS10950	COG0436	Aminotransferase
D1816_RS10960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1816_RS10965	COG0569	domain protein
D1816_RS10970	COG2226	methyltransferase
D1816_RS10995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1816_RS11005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1816_RS11010	COG1185	polyribonucleotide nucleotidyltransferase activity
D1816_RS11040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1816_RS11065	COG0076	glutamate decarboxylase activity
D1816_RS11150	COG1472	Belongs to the glycosyl hydrolase 3 family
D1816_RS11175	COG1162	GTPase activity
D1816_RS11200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1816_RS11215	COG0492	ferredoxin-NADP+ reductase activity
D1816_RS11245	COG1509	lysine 2,3-aminomutase activity
D1816_RS11270	COG0515	serine threonine protein kinase
D1816_RS11270	COG2815	serine threonine protein kinase
D1816_RS11300	COG0302	gtp cyclohydrolase
D1816_RS11315	COG3275	phosphorelay sensor kinase activity
D1816_RS11320	COG3279	Response regulator of the LytR AlgR family
D1816_RS11325	COG0563	adenylate kinase activity
D1816_RS11340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D1816_RS11350	COG0456	acetyltransferase
D1816_RS11390	COG0300	oxidoreductase activity
D1816_RS11420	COG3507	Belongs to the glycosyl hydrolase 43 family
D1816_RS11430	COG4977	sequence-specific DNA binding
D1816_RS11450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1816_RS11500	COG1610	YqeY-like protein
D1816_RS11520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1816_RS11525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1816_RS11530	COG0772	Belongs to the SEDS family
D1816_RS11535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1816_RS11540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1816_RS11545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1816_RS11550	COG0768	penicillin binding
D1816_RS11560	COG0275	rRNA processing
D1816_RS11565	COG2001	Belongs to the MraZ family
D1816_RS11570	COG2267	carboxylic ester hydrolase activity
D1816_RS11575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1816_RS11595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1816_RS11605	COG0358	DNA primase activity
D1816_RS11640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1816_RS11650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1816_RS11655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1816_RS11685	COG1490	D-aminoacyl-tRNA deacylase activity
D1816_RS11690	COG1162	GTPase activity
D1816_RS11700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D1816_RS11705	COG0287	Prephenate dehydrogenase
D1816_RS11710	COG0436	Aminotransferase
D1816_RS11715	COG1605	Chorismate mutase
D1816_RS11715	COG0077	Prephenate dehydratase
D1816_RS11720	COG0156	8-amino-7-oxononanoate synthase activity
D1816_RS11730	COG1522	sequence-specific DNA binding
D1816_RS11735	COG2723	6-phospho-beta-galactosidase activity
D1816_RS11740	COG1131	(ABC) transporter
D1816_RS11745	COG0784	Response regulator, receiver
D1816_RS11745	COG2198	Histidine kinase
D1816_RS11745	COG0643	Histidine kinase
D1816_RS11770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1816_RS11785	COG1410	methionine synthase
D1816_RS11785	COG0646	methionine synthase
D1816_RS11805	COG0633	Ferredoxin
D1816_RS11815	COG0492	ferredoxin-NADP+ reductase activity
D1816_RS11820	COG1648	precorrin-2 dehydrogenase activity
D1816_RS11820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1816_RS11830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1816_RS11840	COG0175	sulfate reduction
D1816_RS11865	COG1765	OsmC-like protein
D1816_RS11870	COG1858	cytochrome C peroxidase
D1816_RS11885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1816_RS11940	COG1428	Deoxynucleoside kinase
D1816_RS11975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1816_RS11980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1816_RS12005	COG0494	nUDIX hydrolase
D1816_RS12015	COG0596	Alpha beta hydrolase
D1816_RS12030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1816_RS12040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1816_RS12060	COG2201	protein-glutamate methylesterase activity
D1816_RS12070	COG0784	Response regulator, receiver
D1816_RS12070	COG5002	protein histidine kinase activity
D1816_RS12075	COG2197	response regulator
D1816_RS12085	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D1816_RS12090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1816_RS12100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D1816_RS12105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1816_RS12115	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1816_RS12120	COG2086	electron transfer activity
D1816_RS12125	COG0022	dehydrogenase e1 component
D1816_RS12125	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1816_RS12135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1816_RS12140	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D1816_RS12245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D1816_RS12255	COG1595	DNA-templated transcription, initiation
D1816_RS12275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1816_RS12275	COG1199	ATP-dependent helicase activity
D1816_RS12295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1816_RS12305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1816_RS12340	COG1914	H( )-stimulated, divalent metal cation uptake system
D1816_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS12350	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D1816_RS12355	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D1816_RS12360	COG2207	Transcriptional regulator
D1816_RS12360	COG0662	Cupin 2, conserved barrel domain protein
D1816_RS12365	COG4677	pectinesterase activity
D1816_RS12370	COG0473	3-isopropylmalate dehydrogenase activity
D1816_RS12370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1816_RS12445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1816_RS12475	COG1428	Deoxynucleoside kinase
D1816_RS12540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1816_RS12550	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1816_RS12555	COG1950	PFAM Membrane protein of
D1816_RS12570	COG0596	Alpha beta hydrolase
D1816_RS12575	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D1816_RS12585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1816_RS12595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1816_RS12615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1816_RS12620	COG3279	Response regulator of the LytR AlgR family
D1816_RS12625	COG3275	phosphorelay sensor kinase activity
D1816_RS12655	COG0640	Transcriptional regulator
D1816_RS12660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1816_RS12680	COG0688	phosphatidylethanolamine metabolic process
D1816_RS12705	COG1331	Highly conserved protein containing a thioredoxin domain
D1816_RS12725	COG1214	PFAM Peptidase M22, glycoprotease
D1816_RS12740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1816_RS12745	COG0577	efflux transmembrane transporter activity
D1816_RS12745	COG1136	(ABC) transporter
D1816_RS12750	COG0577	efflux transmembrane transporter activity
D1816_RS12750	COG1136	(ABC) transporter
D1816_RS12755	COG1136	(ABC) transporter
D1816_RS12765	COG2322	membrane
D1816_RS12770	COG1999	signal sequence binding
D1816_RS12790	COG1845	cytochrome c oxidase, subunit III
D1816_RS12795	COG0109	protoheme IX farnesyltransferase activity
D1816_RS12820	COG0509	glycine decarboxylation via glycine cleavage system
D1816_RS12830	COG0632	four-way junction helicase activity
D1816_RS12840	COG3340	Belongs to the peptidase S51 family
D1816_RS12845	COG0281	malic enzyme
D1816_RS12845	COG0280	phosphate acetyltransferase
D1816_RS12870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1816_RS12895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1816_RS12905	COG2255	four-way junction helicase activity
D1816_RS12920	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D1816_RS12930	COG2271	Major facilitator Superfamily
D1816_RS12935	COG0673	inositol 2-dehydrogenase activity
D1816_RS12945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1816_RS12950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1816_RS12970	COG3743	rRNA binding
D1816_RS12970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1816_RS12975	COG0437	4 iron, 4 sulfur cluster binding
D1816_RS12990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1816_RS12995	COG0195	Participates in both transcription termination and antitermination
D1816_RS13000	COG0779	Required for maturation of 30S ribosomal subunits
D1816_RS13020	COG0726	polysaccharide deacetylase
D1816_RS13025	COG3118	belongs to the thioredoxin family
D1816_RS13035	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1816_RS13035	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1816_RS13065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1816_RS13070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1816_RS13075	COG0052	Belongs to the universal ribosomal protein uS2 family
D1816_RS13080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1816_RS13085	COG0528	UMP kinase activity
D1816_RS13090	COG0233	cytoplasmic translational termination
D1816_RS13105	COG0017	Asparaginyl-tRNA synthetase
D1816_RS13125	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1816_RS13145	COG0393	Putative heavy-metal-binding
D1816_RS13175	COG2255	four-way junction helicase activity
D1816_RS13215	COG4585	Histidine kinase
D1816_RS13220	COG2197	response regulator
D1816_RS13225	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D1816_RS13265	COG0811	peptide transport
D1816_RS13275	COG0252	asparaginase activity
D1816_RS13280	COG0084	hydrolase, TatD family'
D1816_RS13335	COG0138	bifunctional purine biosynthesis protein purh
D1816_RS13340	COG1077	Cell shape determining protein MreB Mrl
D1816_RS13355	COG0768	penicillin binding
D1816_RS13360	COG0772	Belongs to the SEDS family
D1816_RS13375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1816_RS13385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D1816_RS13395	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1816_RS13400	COG0791	NLP P60 protein
D1816_RS13405	COG0658	competence protein
D1816_RS13405	COG2333	competence protein COMEC
D1816_RS13420	COG3104	oligopeptide transport
D1816_RS13425	COG3104	oligopeptide transport
D1816_RS13430	COG0823	Involved in the tonB-independent uptake of proteins
D1816_RS13430	COG1506	peptidase
D1816_RS13455	COG1695	Transcriptional regulator
D1816_RS13465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1816_RS13475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1816_RS13485	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS13525	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1816_RS13555	COG1309	transcriptional regulator
D1816_RS13580	COG4771	TonB-dependent receptor
D1816_RS13585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1816_RS13610	COG1278	Cold shock
D1816_RS13630	COG0590	tRNA wobble adenosine to inosine editing
D1816_RS13635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1816_RS13645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1816_RS13655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D1816_RS13660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1816_RS13660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1816_RS13675	COG2095	MarC family integral membrane protein
D1816_RS13705	COG4968	Prepilin-type N-terminal cleavage methylation domain
D1816_RS13830	COG1472	Belongs to the glycosyl hydrolase 3 family
D1816_RS13835	COG3292	Two component regulator propeller
D1816_RS13835	COG2205	protein histidine kinase activity
D1816_RS13835	COG0745	RESPONSE REGULATOR receiver
D1816_RS13875	COG3621	Patatin-like phospholipase
D1816_RS13985	COG1917	Cupin 2, conserved barrel domain protein
D1816_RS13990	COG2271	Major facilitator Superfamily
D1816_RS13995	COG1802	Transcriptional regulator
D1816_RS14000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1816_RS14010	COG1690	Belongs to the RtcB family
D1816_RS14040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1816_RS14045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1816_RS14050	COG0193	aminoacyl-tRNA hydrolase activity
D1816_RS14055	COG0196	riboflavin kinase activity
D1816_RS14070	COG3040	lipid binding
D1816_RS14090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1816_RS14105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1816_RS14110	COG2239	Acts as a magnesium transporter
D1816_RS14165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1816_RS14175	COG2197	response regulator
D1816_RS14230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1816_RS14235	COG0668	transmembrane transport
D1816_RS14240	COG0668	transmembrane transport
D1816_RS14255	COG0527	aspartate kinase activity
D1816_RS14265	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D1816_RS14285	COG2205	protein histidine kinase activity
D1816_RS14285	COG0784	Response regulator, receiver
D1816_RS14315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1816_RS14330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1816_RS14370	COG0667	Aldo Keto reductase
D1816_RS14375	COG0792	nuclease activity
D1816_RS14380	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1816_RS14395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1816_RS14395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1816_RS14405	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1816_RS14440	COG1053	succinate dehydrogenase
D1816_RS14450	COG0436	Aminotransferase
D1816_RS14455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1816_RS14480	COG2954	triphosphatase activity
D1816_RS14505	COG4953	penicillin-binding protein 1C
D1816_RS14520	COG2311	Membrane
D1816_RS14525	COG2311	Membrane
D1816_RS14530	COG2373	Large extracellular alpha-helical protein
D1816_RS14550	COG1446	asparaginase
D1816_RS14580	COG1404	Belongs to the peptidase S8 family
D1816_RS14590	COG1418	mRNA catabolic process
D1816_RS14655	COG1999	signal sequence binding
D1816_RS14660	COG0750	zinc metalloprotease
D1816_RS14670	COG3858	chitin binding
D1816_RS14670	COG1388	LysM domain
D1816_RS14680	COG2255	four-way junction helicase activity
D1816_RS14695	COG1192	Involved in chromosome partitioning
D1816_RS14795	COG2197	response regulator
D1816_RS14835	COG0545	Peptidyl-prolyl cis-trans isomerase
D1816_RS14855	COG1136	(ABC) transporter
D1816_RS14860	COG0577	efflux transmembrane transporter activity
D1816_RS14860	COG1136	(ABC) transporter
D1816_RS14900	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1816_RS14925	COG1381	Involved in DNA repair and RecF pathway recombination
D1816_RS14940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1816_RS14945	COG0626	cystathionine gamma-synthase activity
D1816_RS15025	COG3781	membrane
D1816_RS15030	COG0429	hydrolase of the alpha beta-hydrolase fold
D1816_RS15045	COG0604	alcohol dehydrogenase
D1816_RS15070	COG3033	Beta-eliminating lyase
D1816_RS15075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1816_RS15100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D1816_RS15150	COG3275	phosphorelay sensor kinase activity
D1816_RS15155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1816_RS15160	COG1253	flavin adenine dinucleotide binding
D1816_RS15180	COG0113	porphobilinogen synthase activity
D1816_RS15185	COG1131	(ABC) transporter
D1816_RS15225	COG1404	Belongs to the peptidase S8 family
D1816_RS15225	COG4935	Belongs to the peptidase S8 family
D1816_RS15235	COG1136	(ABC) transporter
D1816_RS15235	COG0577	efflux transmembrane transporter activity
D1816_RS15275	COG0577	efflux transmembrane transporter activity
D1816_RS15290	COG0577	efflux transmembrane transporter activity
D1816_RS15290	COG1136	(ABC) transporter
D1816_RS15295	COG0577	efflux transmembrane transporter activity
D1816_RS15305	COG1136	(ABC) transporter
D1816_RS15305	COG0577	efflux transmembrane transporter activity
D1816_RS15340	COG0408	coproporphyrinogen oxidase activity
D1816_RS15345	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D1816_RS15355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1816_RS15370	COG0181	hydroxymethylbilane synthase activity
D1816_RS15375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1816_RS15385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1816_RS15410	COG2133	pyrroloquinoline quinone binding
D1816_RS15425	COG2827	Endonuclease containing a URI domain
D1816_RS15430	COG1981	membrane
D1816_RS15445	COG1561	YicC-like family, N-terminal region
D1816_RS15450	COG0194	GDP metabolic process
D1816_RS15455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1816_RS15500	COG1024	Enoyl-CoA hydratase
D1816_RS15515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D1816_RS15525	COG0450	alkyl hydroperoxide reductase
D1816_RS15530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D1816_RS15535	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1816_RS15545	COG1774	PSP1 C-terminal conserved region
D1816_RS15550	COG1054	Belongs to the UPF0176 family
D1816_RS15560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1816_RS15575	COG1595	DNA-templated transcription, initiation
D1816_RS15585	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1816_RS15600	COG0180	Tryptophanyl-tRNA synthetase
D1816_RS15635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1816_RS15690	COG0659	secondary active sulfate transmembrane transporter activity
D1816_RS15700	COG0659	secondary active sulfate transmembrane transporter activity
D1816_RS15725	COG1733	regulation of RNA biosynthetic process
D1816_RS15755	COG2304	oxidoreductase activity
D1816_RS15760	COG2304	oxidoreductase activity
D1816_RS15775	COG0714	Associated with various cellular activities
D1816_RS15780	COG4221	oxidoreductase activity
D1816_RS15810	COG4260	virion core protein, lumpy skin disease virus
D1816_RS15840	COG1012	belongs to the aldehyde dehydrogenase family
D1816_RS15845	COG0662	Cupin 2, conserved barrel domain protein
D1816_RS15855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1816_RS15865	COG2897	thiosulfate sulfurtransferase activity
D1816_RS15870	COG1472	Belongs to the glycosyl hydrolase 3 family
D1816_RS15935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1816_RS15935	COG0758	DNA mediated transformation
D1816_RS15950	COG1607	acyl-coa hydrolase
D1816_RS15970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1816_RS15975	COG0756	dUTP diphosphatase activity
D1816_RS16005	COG3279	Response regulator of the LytR AlgR family
D1816_RS16010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1816_RS16015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1816_RS16020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1816_RS16025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1816_RS16030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1816_RS16035	COG0356	it plays a direct role in the translocation of protons across the membrane
D1816_RS16095	COG0151	Belongs to the GarS family
D1816_RS16130	COG3307	-O-antigen
D1816_RS16135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1816_RS16145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1816_RS16155	COG0579	oxidoreductase
D1816_RS16170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1816_RS16180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1816_RS16185	COG0673	inositol 2-dehydrogenase activity
D1816_RS16235	COG1696	Membrane protein involved in D-alanine export
D1816_RS16255	COG1088	dTDP-glucose 4,6-dehydratase activity
D1816_RS16260	COG1482	cell wall glycoprotein biosynthetic process
D1816_RS16285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1816_RS16335	COG1388	LysM domain
D1816_RS16335	COG0741	lytic transglycosylase activity
D1816_RS16340	COG0126	phosphoglycerate kinase activity
D1816_RS16345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1816_RS16350	COG0470	DNA polymerase III
D1816_RS16405	COG0445	tRNA wobble uridine modification
D1816_RS16410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1816_RS16425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1816_RS16430	COG0330	HflC and HflK could
D1816_RS16435	COG2273	Hydrolase Family 16
D1816_RS16445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1816_RS16450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1816_RS16470	COG0557	exoribonuclease II activity
D1816_RS16480	COG0698	ribose 5-phosphate isomerase
D1816_RS16490	COG2153	protein acetylation
D1816_RS16515	COG1404	Belongs to the peptidase S8 family
D1816_RS16585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1816_RS16600	COG0594	ribonuclease P activity
D1816_RS16605	COG0793	Belongs to the peptidase S41A family
D1816_RS16630	COG4305	rare lipoprotein A
D1816_RS16645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1816_RS16670	COG2151	metal-sulfur cluster biosynthetic enzyme
D1816_RS16675	COG2166	iron-sulfur cluster assembly
D1816_RS16695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1816_RS16705	COG0719	Fe-S assembly protein
D1816_RS16710	COG0396	ATPase activity
D1816_RS16725	COG0719	Fe-S assembly protein
D1816_RS16735	COG1858	cytochrome C peroxidase
D1816_RS16760	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1816_RS16780	COG1858	cytochrome C peroxidase
D1816_RS16820	COG0006	proline dipeptidase activity
D1816_RS16835	COG1956	GAF domain-containing protein
D1816_RS16855	COG5002	protein histidine kinase activity
D1816_RS16860	COG2201	protein-glutamate methylesterase activity
D1816_RS16865	COG0469	pyruvate kinase activity
D1816_RS16875	COG0571	ribonuclease III activity
D1816_RS16880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1816_RS16885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1816_RS16890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1816_RS16895	COG0328	RNA-DNA hybrid ribonuclease activity
D1816_RS16895	COG3341	Caulimovirus viroplasmin
D1816_RS16940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1816_RS16945	COG1074	ATP-dependent DNA helicase activity
D1816_RS16950	COG3047	cAMP biosynthetic process
D1816_RS16950	COG2885	chlorophyll binding
D1816_RS16955	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D1816_RS16990	COG0784	Response regulator, receiver
D1816_RS16990	COG5002	protein histidine kinase activity
D1816_RS16990	COG2198	Histidine kinase
D1816_RS17025	COG2207	Transcriptional regulator
D1816_RS17050	COG0534	Mate efflux family protein
D1816_RS17065	COG0720	synthase
D1816_RS17070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1816_RS17080	COG3842	ATPase activity
D1816_RS17085	COG1505	serine-type exopeptidase activity
D1816_RS17100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1816_RS17105	COG1970	mechanosensitive ion channel activity
D1816_RS17110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1816_RS17115	COG1435	thymidine kinase activity
D1816_RS17130	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1816_RS17170	COG4585	Histidine kinase
D1816_RS17185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1816_RS17185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D1816_RS17195	COG0596	Alpha beta hydrolase
D1816_RS17215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1816_RS17225	COG0439	Biotin carboxylase
D1816_RS17230	COG0511	ligase activity, forming carbon-carbon bonds
D1816_RS17235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1816_RS17240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1816_RS17250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D1816_RS17290	COG2234	aminopeptidase activity
D1816_RS17295	COG0598	Magnesium transport protein CorA
D1816_RS17305	COG3104	oligopeptide transport
D1816_RS17330	COG0346	lactoylglutathione lyase activity
D1816_RS17340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1816_RS17360	COG0481	GTPase activity
D1816_RS17450	COG0464	growth
D1816_RS17455	COG0561	phosphatase activity
D1816_RS17475	COG4771	TonB-dependent receptor
D1816_RS17480	COG0166	Belongs to the GPI family
D1816_RS17500	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D1816_RS17505	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1816_RS17510	COG1752	Esterase of the alpha-beta hydrolase superfamily
D1816_RS17515	COG0322	excinuclease ABC activity
D1816_RS17525	COG0189	ligase activity
D1816_RS17535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1816_RS17540	COG2201	protein-glutamate methylesterase activity
D1816_RS17545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1816_RS17565	COG1595	DNA-templated transcription, initiation
D1816_RS17570	COG3338	carbonate dehydratase activity
D1816_RS17590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1816_RS17615	COG1040	competence protein
D1816_RS17625	COG0423	glycine-tRNA ligase activity
D1816_RS17640	COG0708	Exodeoxyribonuclease III
D1816_RS17645	COG1360	Flagellar Motor Protein
D1816_RS17685	COG0667	Aldo Keto reductase
D1816_RS17720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1816_RS17735	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D1816_RS17740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1816_RS17745	COG0297	glycogen (starch) synthase activity
D1816_RS17755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1816_RS17765	COG4771	TonB-dependent receptor
D1816_RS17790	COG0385	Bile acid
D1816_RS17810	COG1131	(ABC) transporter
D1816_RS17815	COG3275	phosphorelay sensor kinase activity
D1816_RS17820	COG3279	Response regulator of the LytR AlgR family
D1816_RS17835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1816_RS17840	COG3655	Transcriptional regulator
D1816_RS17850	COG0156	8-amino-7-oxononanoate synthase activity
D1816_RS17855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1816_RS17865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1816_RS17880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1816_RS17885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1816_RS18000	COG2274	protein secretion by the type I secretion system
D1816_RS18005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1816_RS18035	COG1505	serine-type exopeptidase activity
D1816_RS18050	COG1530	ribonuclease E activity
D1816_RS18055	COG0776	regulation of translation
D1816_RS18090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1816_RS18095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1816_RS18115	COG1131	(ABC) transporter
D1816_RS18120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1816_RS18150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1816_RS18160	COG2204	response regulator
D1816_RS18180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1816_RS18190	COG0351	phosphomethylpyrimidine kinase
D1816_RS18195	COG0352	thiamine-phosphate diphosphorylase activity
D1816_RS18200	COG2022	thiamine diphosphate biosynthetic process
D1816_RS18205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1816_RS18215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1816_RS18235	COG3852	Histidine kinase
D1816_RS18240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1816_RS18250	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D1816_RS18255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1816_RS18260	COG4771	TonB-dependent receptor
D1816_RS18275	COG0519	Catalyzes the synthesis of GMP from XMP
D1816_RS18280	COG4946	Tricorn protease homolog
D1816_RS18280	COG0793	Belongs to the peptidase S41A family
D1816_RS18295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1816_RS18300	COG1968	undecaprenyl-diphosphatase activity
D1816_RS18315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1816_RS18320	COG2177	Part of the ABC transporter FtsEX involved in
D1816_RS18325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1816_RS18330	COG0495	leucyl-tRNA aminoacylation
D1816_RS18350	COG2738	Putative neutral zinc metallopeptidase
D1816_RS18355	COG1522	sequence-specific DNA binding
D1816_RS18375	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D1816_RS18390	COG0463	Glycosyl transferase, family 2
D1816_RS18395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1816_RS18410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1816_RS18430	COG0534	Mate efflux family protein
D1816_RS18455	COG1629	transport
D1816_RS18470	COG0745	RESPONSE REGULATOR receiver
D1816_RS18475	COG5002	protein histidine kinase activity
D1816_RS18480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1816_RS18485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1816_RS18525	COG1902	pentaerythritol trinitrate reductase activity
D1816_RS18550	COG0489	protein tyrosine kinase activity
D1816_RS18590	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1816_RS18605	COG0589	response to stress
D1816_RS18670	COG3118	belongs to the thioredoxin family
D1816_RS18700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1816_RS18720	COG2010	Cytochrome c
D1816_RS18730	COG3278	Belongs to the heme-copper respiratory oxidase family
D1816_RS18745	COG0259	pyridoxamine-phosphate oxidase activity
D1816_RS18750	COG2217	Heavy metal translocating P-type atpase
D1816_RS18765	COG0589	response to stress
D1816_RS18775	COG0589	response to stress
D1816_RS18815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1816_RS18835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1816_RS18865	COG0315	cyclic pyranopterin monophosphate synthase activity
D1816_RS18865	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1816_RS18875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1816_RS18885	COG0746	molybdenum cofactor guanylyltransferase activity
D1816_RS18895	COG0303	'Molybdopterin
D1816_RS18945	COG3527	Alpha-acetolactate decarboxylase
D1816_RS18955	COG0010	Belongs to the arginase family
D1816_RS19005	COG2211	Major facilitator Superfamily
D1816_RS19010	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
D1816_RS19015	COG2942	2-epimerase
D1816_RS19020	COG4771	TonB-dependent receptor
D1816_RS19035	COG2423	ornithine cyclodeaminase activity
D1816_RS19045	COG2207	Transcriptional regulator
D1816_RS19070	COG1131	(ABC) transporter
D1816_RS19125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1816_RS19130	COG3321	synthase
D1816_RS19130	COG0604	alcohol dehydrogenase
D1816_RS19185	COG2217	Heavy metal translocating P-type atpase
D1816_RS19195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1816_RS19220	COG2608	mercury ion transmembrane transporter activity
D1816_RS19265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1816_RS19295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1816_RS19300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1816_RS19325	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1816_RS19380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D1816_RS19405	COG2003	Belongs to the UPF0758 family
D1816_RS19410	COG0629	single-stranded DNA binding
D1816_RS19435	COG1475	DNA binding
D1816_RS19440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1816_RS19485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1816_RS19490	COG3938	Belongs to the proline racemase family
D1816_RS19530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1816_RS19535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1816_RS19580	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1816_RS19600	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D1816_RS19710	COG0228	four-way junction DNA binding
D1816_RS19715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1816_RS19720	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D1816_RS19730	COG1960	acyl-CoA dehydrogenase activity
D1816_RS19760	COG0584	glycerophosphoryl diester phosphodiesterase
D1816_RS19765	COG2081	HI0933 family
D1816_RS19780	COG1309	transcriptional regulator
D1816_RS19785	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D1816_RS19815	COG1187	pseudouridine synthase activity
D1816_RS19825	COG1215	transferase activity, transferring glycosyl groups
D1816_RS19845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1816_RS19885	COG2084	Dehydrogenase
D1816_RS19895	COG4977	sequence-specific DNA binding
D1816_RS19895	COG1917	Cupin 2, conserved barrel domain protein
D1816_RS19920	COG1902	pentaerythritol trinitrate reductase activity
D1816_RS19920	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1816_RS19935	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1816_RS19945	COG1054	Belongs to the UPF0176 family
D1816_RS19955	COG3842	ATPase activity
D1816_RS19970	COG4134	Bacterial extracellular solute-binding protein
D1816_RS19990	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1816_RS19995	COG1472	Belongs to the glycosyl hydrolase 3 family
D1816_RS20015	COG0366	Alpha amylase catalytic
D1816_RS20020	COG4771	TonB-dependent receptor
D1816_RS20025	COG0702	epimerase
D1816_RS20055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1816_RS20060	COG0671	phosphoesterase, PA-phosphatase related
D1816_RS20085	COG0183	Belongs to the thiolase family
D1816_RS20105	COG0745	RESPONSE REGULATOR receiver
D1816_RS20105	COG2205	protein histidine kinase activity
D1816_RS20105	COG3292	Two component regulator propeller
D1816_RS20125	COG3250	beta-galactosidase activity
D1816_RS20135	COG0583	DNA-binding transcription factor activity
D1816_RS20145	COG2226	methyltransferase
D1816_RS20150	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1816_RS20175	COG0300	oxidoreductase activity
D1816_RS20180	COG0492	ferredoxin-NADP+ reductase activity
D1816_RS20250	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS20270	COG2207	Transcriptional regulator
D1816_RS20270	COG4753	response regulator
D1816_RS20275	COG4221	oxidoreductase activity
D1816_RS20285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1816_RS20310	COG1253	flavin adenine dinucleotide binding
D1816_RS20320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1816_RS20325	COG0647	UMP catabolic process
D1816_RS20330	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1816_RS20345	COG0702	epimerase
D1816_RS20350	COG4771	TonB-dependent receptor
D1816_RS20355	COG1725	Transcriptional regulator
D1816_RS20365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1816_RS20370	COG1085	galactose-1-phosphate uridylyltransferase
D1816_RS20390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1816_RS20400	COG0459	protein refolding
D1816_RS20405	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1816_RS20425	COG3829	transcription factor binding
D1816_RS20430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1816_RS20440	COG1754	DNA topoisomerase type I activity
D1816_RS20440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1816_RS20450	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1816_RS20480	COG0488	(ABC) transporter
D1816_RS20545	COG0745	RESPONSE REGULATOR receiver
D1816_RS20545	COG2205	protein histidine kinase activity
D1816_RS20545	COG3292	Two component regulator propeller
D1816_RS20555	COG1431	PFAM Stem cell self-renewal protein Piwi
D1816_RS20595	COG2207	Transcriptional regulator
D1816_RS20595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1816_RS20685	COG4221	oxidoreductase activity
D1816_RS20700	COG1902	pentaerythritol trinitrate reductase activity
D1816_RS20715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1816_RS20715	COG2207	Transcriptional regulator
D1816_RS20720	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1816_RS20745	COG1902	pentaerythritol trinitrate reductase activity
D1816_RS20750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1816_RS20770	COG4771	TonB-dependent receptor
D1816_RS20780	COG0583	DNA-binding transcription factor activity
D1816_RS20790	COG0463	Glycosyl transferase, family 2
D1816_RS20820	COG1629	transport
D1816_RS20855	COG0076	glutamate decarboxylase activity
D1816_RS20860	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D1816_RS20970	COG0463	Glycosyl transferase, family 2
D1816_RS21025	COG4628	conserved protein (DUF2132)
D1816_RS21045	COG5002	protein histidine kinase activity
D1816_RS21055	COG4251	negative regulation of phosphorylation
D1816_RS21065	COG0784	Response regulator, receiver
D1816_RS21090	COG1793	dna ligase
D1816_RS21095	COG1201	RNA secondary structure unwinding
D1816_RS21110	COG0415	Belongs to the DNA photolyase family
D1816_RS21115	COG3046	protein related to deoxyribodipyrimidine photolyase
D1816_RS21120	COG0415	Belongs to the DNA photolyase family
D1816_RS21150	COG4771	TonB-dependent receptor
D1816_RS21155	COG0702	epimerase
D1816_RS21175	COG3279	Response regulator of the LytR AlgR family
D1816_RS21180	COG2972	Histidine kinase
D1816_RS21180	COG0745	RESPONSE REGULATOR receiver
D1816_RS21200	COG1115	amino acid carrier protein
D1816_RS21210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1816_RS21225	COG1160	GTP binding
D1816_RS21245	COG0641	radical SAM
D1816_RS21300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1816_RS21310	COG3186	Phenylalanine-4-hydroxylase
D1816_RS21325	COG1309	transcriptional regulator
D1816_RS21330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1816_RS21335	COG3396	Phenylacetate-CoA oxygenase
D1816_RS21340	COG3460	Phenylacetate-CoA oxygenase
D1816_RS21345	COG3396	Phenylacetate-CoA oxygenase
D1816_RS21350	COG2151	metal-sulfur cluster biosynthetic enzyme
D1816_RS21360	COG1024	Enoyl-CoA hydratase
D1816_RS21365	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1816_RS21380	COG0183	Belongs to the thiolase family
D1816_RS21385	COG2030	dehydratase
D1816_RS21385	COG1012	belongs to the aldehyde dehydrogenase family
D1816_RS21400	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1816_RS21405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1816_RS21410	COG0022	dehydrogenase e1 component
D1816_RS21435	COG3250	beta-galactosidase activity
D1816_RS21445	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1816_RS21460	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1816_RS21470	COG0028	Belongs to the TPP enzyme family
D1816_RS21485	COG0069	glutamate synthase activity
D1816_RS21495	COG0629	single-stranded DNA binding
D1816_RS21535	COG1595	DNA-templated transcription, initiation
D1816_RS21540	COG0384	phenazine biosynthesis protein PhzF
D1816_RS21565	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D1816_RS21570	COG3942	CHAP domain
D1816_RS21570	COG1388	LysM domain
D1816_RS21575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1816_RS21620	COG4682	membrane
D1816_RS21655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1816_RS21680	COG0401	homolog of Blt101
D1816_RS21690	COG0321	lipoyl(octanoyl) transferase activity
D1816_RS21705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1816_RS21750	COG1960	acyl-CoA dehydrogenase activity
D1816_RS21760	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1816_RS21765	COG0811	peptide transport
D1816_RS21770	COG0848	biopolymer transport protein
D1816_RS21795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1816_RS21800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1816_RS21810	COG0295	cytidine deaminase activity
D1816_RS21815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1816_RS21820	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1816_RS21860	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D1816_RS21860	COG0662	Cupin 2, conserved barrel domain protein
D1816_RS21885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1816_RS21890	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
D1816_RS21895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS21900	COG1215	transferase activity, transferring glycosyl groups
D1816_RS21910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1816_RS21920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1816_RS21920	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1816_RS21985	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1816_RS21990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1816_RS21995	COG0563	adenylate kinase activity
D1816_RS22000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1816_RS22015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1816_RS22040	COG2373	Large extracellular alpha-helical protein
D1816_RS22045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1816_RS22065	COG2003	Belongs to the UPF0758 family
D1816_RS22095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1816_RS22105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1816_RS22115	COG4771	TonB-dependent receptor
D1816_RS22125	COG4206	TonB-dependent receptor
D1816_RS22125	COG1629	transport
D1816_RS22140	COG1629	transport
D1816_RS22140	COG1629	transport
D1816_RS22145	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1816_RS22150	COG0049	tRNA binding
D1816_RS22155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1816_RS22160	COG0051	transcription antitermination factor activity, RNA binding
D1816_RS22165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1816_RS22170	COG0088	Forms part of the polypeptide exit tunnel
D1816_RS22175	COG0089	rRNA binding
D1816_RS22180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1816_RS22185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1816_RS22190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1816_RS22195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1816_RS22200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1816_RS22205	COG0255	Belongs to the universal ribosomal protein uL29 family
D1816_RS22210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1816_RS22215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1816_RS22220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1816_RS22225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1816_RS22230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1816_RS22235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1816_RS22240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1816_RS22245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1816_RS22250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1816_RS22255	COG1841	ribosomal large subunit assembly
D1816_RS22260	COG0200	Binds to the 23S rRNA
D1816_RS22270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1816_RS22275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1816_RS22280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1816_RS22285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1816_RS22290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1816_RS22295	COG0202	RNA polymerase activity
D1816_RS22300	COG0203	ribosomal protein L17
D1816_RS22305	COG0505	Belongs to the CarA family
D1816_RS22310	COG0148	phosphopyruvate hydratase activity
D1816_RS22330	COG1959	2 iron, 2 sulfur cluster binding
D1816_RS22340	COG0702	epimerase
D1816_RS22345	COG0018	arginyl-trna synthetase
D1816_RS22360	COG3712	iron ion homeostasis
D1816_RS22375	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1816_RS22380	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1816_RS22385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1816_RS22390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1816_RS22420	COG0101	tRNA pseudouridine synthase activity
D1816_RS22425	COG1132	(ABC) transporter
D1816_RS22435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D1816_RS22440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1816_RS22455	COG0601	transmembrane transport
D1816_RS22460	COG0149	triose-phosphate isomerase activity
D1816_RS22465	COG2264	protein methyltransferase activity
D1816_RS22490	COG1132	(ABC) transporter
D1816_RS22505	COG1070	Carbohydrate kinase
D1816_RS22520	COG2198	Histidine kinase
D1816_RS22520	COG5002	protein histidine kinase activity
D1816_RS22520	COG0784	Response regulator, receiver
D1816_RS22535	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1816_RS22570	COG3275	phosphorelay sensor kinase activity
D1816_RS22575	COG3279	Response regulator of the LytR AlgR family
D1816_RS22595	COG1333	cytochrome c biogenesis protein
D1816_RS22595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1816_RS22600	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D1816_RS22610	COG1234	tRNA 3'-trailer cleavage
D1816_RS22635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1816_RS22655	COG3275	phosphorelay sensor kinase activity
D1816_RS22660	COG3279	Response regulator of the LytR AlgR family
D1816_RS22685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1816_RS22695	COG0243	molybdopterin cofactor binding
D1816_RS22710	COG0437	4 iron, 4 sulfur cluster binding
D1816_RS22720	COG1492	cobalamin metabolic process
D1816_RS22730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D1816_RS22740	COG4206	TonB-dependent receptor
D1816_RS22755	COG1648	precorrin-2 dehydrogenase activity
D1816_RS22755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1816_RS22760	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D1816_RS22765	COG2345	Transcriptional regulator
D1816_RS22805	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1816_RS22815	COG0024	Methionine aminopeptidase
D1816_RS22840	COG1797	cobyrinic acid a,c-diamide synthase activity
D1816_RS22845	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D1816_RS22885	COG0778	Nitroreductase
D1816_RS22900	COG2096	Adenosyltransferase
D1816_RS22910	COG0640	Transcriptional regulator
D1816_RS22915	COG1090	epimerase
D1816_RS22930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D1816_RS22935	COG2197	response regulator
D1816_RS23000	COG4974	Belongs to the 'phage' integrase family
D1816_RS23045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1816_RS23075	COG0174	glutamine synthetase
D1816_RS23115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1816_RS23120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1816_RS23125	COG5002	protein histidine kinase activity
D1816_RS23130	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1816_RS23140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1816_RS23150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1816_RS23155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1816_RS23160	COG0215	cysteine-tRNA ligase activity
D1816_RS23165	COG0302	gtp cyclohydrolase
D1816_RS23185	COG0442	prolyl-tRNA aminoacylation
D1816_RS23200	COG0268	Binds directly to 16S ribosomal RNA
D1816_RS23220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1816_RS23225	COG1663	tetraacyldisaccharide 4'-kinase activity
D1816_RS23235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1816_RS23240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1816_RS23260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1816_RS23265	COG0436	Aminotransferase
D1816_RS23270	COG0750	zinc metalloprotease
D1816_RS23280	COG0525	valine-tRNA ligase activity
D1816_RS23290	COG0688	phosphatidylethanolamine metabolic process
D1816_RS23305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1816_RS23310	COG0799	negative regulation of ribosome biogenesis
D1816_RS23325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1816_RS23330	COG1051	belongs to the nudix hydrolase family
D1816_RS23340	COG1131	(ABC) transporter
D1816_RS23350	COG0659	secondary active sulfate transmembrane transporter activity
D1816_RS23375	COG3401	FG-GAP repeat protein
D1816_RS23380	COG3401	FG-GAP repeat protein
D1816_RS23385	COG3401	FG-GAP repeat protein
D1816_RS23410	COG0346	lactoylglutathione lyase activity
D1816_RS23415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1816_RS23420	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1816_RS23430	COG0564	pseudouridine synthase activity
D1816_RS23435	COG1278	Cold shock
D1816_RS23450	COG3401	FG-GAP repeat protein
D1816_RS23460	COG3022	response to hydroperoxide
D1816_RS23475	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1816_RS23485	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D1816_RS23510	COG1696	Membrane protein involved in D-alanine export
D1816_RS23520	COG0584	glycerophosphoryl diester phosphodiesterase
D1816_RS23525	COG0159	tryptophan synthase activity
D1816_RS23530	COG0133	tryptophan synthase activity
D1816_RS23535	COG0135	phosphoribosylanthranilate isomerase activity
D1816_RS23545	COG0134	indole-3-glycerol-phosphate synthase activity
D1816_RS23550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1816_RS23555	COG0512	Glutamine amidotransferase of anthranilate synthase
D1816_RS23560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1816_RS23575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS23585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1816_RS23590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1816_RS23595	COG0800	Aldolase
D1816_RS23620	COG0702	epimerase
D1816_RS23625	COG4771	TonB-dependent receptor
D1816_RS23650	COG2017	converts alpha-aldose to the beta-anomer
D1816_RS23655	COG4948	Mandelate Racemase Muconate Lactonizing
D1816_RS23660	COG1012	belongs to the aldehyde dehydrogenase family
D1816_RS23665	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS23680	COG3250	beta-galactosidase activity
D1816_RS23715	COG1028	Short-chain dehydrogenase reductase Sdr
D1816_RS23815	COG2197	response regulator
D1816_RS23835	COG0284	orotidine-5'-phosphate decarboxylase activity
D1816_RS23840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1816_RS23860	COG0788	formyltetrahydrofolate deformylase activity
D1816_RS23865	COG1703	isobutyryl-CoA mutase activity
D1816_RS23865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1816_RS23865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1816_RS23875	COG1115	amino acid carrier protein
D1816_RS23880	COG0804	urea catabolic process
D1816_RS23890	COG1522	sequence-specific DNA binding
D1816_RS23900	COG4977	sequence-specific DNA binding
D1816_RS23905	COG0477	Major facilitator Superfamily
D1816_RS23905	COG2814	Major facilitator Superfamily
D1816_RS23920	COG0347	Belongs to the P(II) protein family
D1816_RS23925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1816_RS23950	COG4585	Histidine kinase
D1816_RS23975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1816_RS23985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1816_RS23985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1816_RS23990	COG1090	epimerase
D1816_RS24000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1816_RS24005	COG0484	heat shock protein binding
D1816_RS24010	COG4152	abc transporter atp-binding protein
D1816_RS24015	COG1668	transmembrane transport
D1816_RS24020	COG3264	Mechanosensitive ion channel
D1816_RS24020	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1816_RS24040	COG2326	polyphosphate kinase activity
D1816_RS24065	COG0534	Mate efflux family protein
D1816_RS24080	COG0671	phosphoesterase, PA-phosphatase related
D1816_RS24085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1816_RS24100	COG1703	isobutyryl-CoA mutase activity
D1816_RS24150	COG2072	flavoprotein involved in K transport
D1816_RS24170	COG0653	protein targeting
D1816_RS24180	COG2096	Adenosyltransferase
D1816_RS24185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1816_RS24195	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1816_RS24210	COG2207	Transcriptional regulator
D1816_RS24225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1816_RS24230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1816_RS24235	COG1121	(ABC) transporter
D1816_RS24240	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1816_RS24250	COG4771	TonB-dependent receptor
D1816_RS24260	COG2176	DNA-directed DNA polymerase activity
D1816_RS24260	COG5002	protein histidine kinase activity
D1816_RS24265	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1816_RS24275	COG1058	Belongs to the CinA family
D1816_RS24275	COG1546	Belongs to the CinA family
D1816_RS24295	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1816_RS24300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1816_RS24310	COG0552	protein localization to endoplasmic reticulum
D1816_RS24350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1816_RS24360	COG4251	negative regulation of phosphorylation
D1816_RS24365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1816_RS24380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1816_RS24415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1816_RS24420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1816_RS24425	COG0745	RESPONSE REGULATOR receiver
D1816_RS24425	COG3292	Two component regulator propeller
D1816_RS24425	COG2205	protein histidine kinase activity
D1816_RS24445	COG1063	alcohol dehydrogenase
D1816_RS24455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1816_RS24475	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1816_RS24520	COG0339	signal peptide processing
D1816_RS24530	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D1816_RS24575	COG0519	Catalyzes the synthesis of GMP from XMP
D1816_RS24575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1816_RS24590	COG3530	Putative quorum-sensing-regulated virulence factor
D1816_RS24600	COG1228	amidohydrolase
D1816_RS24605	COG0019	diaminopimelate decarboxylase activity
D1816_RS24615	COG0045	succinate-CoA ligase (ADP-forming) activity
D1816_RS24630	COG0667	Aldo Keto reductase
D1816_RS24660	COG0071	Belongs to the small heat shock protein (HSP20) family
D1816_RS24680	COG2205	protein histidine kinase activity
D1816_RS24695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1816_RS24725	COG1131	(ABC) transporter
D1816_RS24760	COG1612	heme a metabolic process
D1816_RS24765	COG0617	tRNA 3'-terminal CCA addition
D1816_RS24765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1816_RS24765	COG0517	IMP dehydrogenase activity
D1816_RS24770	COG0009	L-threonylcarbamoyladenylate synthase
D1816_RS24785	COG0297	glycogen (starch) synthase activity
D1816_RS24805	COG2171	N-acyltransferase activity
D1816_RS24810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1816_RS24815	COG0242	peptide deformylase activity
D1816_RS24825	COG0504	CTP synthase activity
D1816_RS24830	COG0706	membrane insertase activity
D1816_RS24850	COG0482	sulfurtransferase activity
D1816_RS24860	COG3956	TIGRFAM MazG family protein
D1816_RS24865	COG0366	Alpha amylase catalytic
D1816_RS24865	COG1874	Beta-galactosidase
D1816_RS24880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1816_RS24900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1816_RS24915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1816_RS24920	COG0735	belongs to the Fur family
D1816_RS24925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1816_RS24930	COG0501	Belongs to the peptidase M48B family
D1816_RS24935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1816_RS24950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1816_RS24955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1816_RS24960	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1816_RS24965	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1816_RS24995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS25015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1816_RS25050	COG1595	DNA-templated transcription, initiation
D1816_RS25060	COG0335	large ribosomal subunit rRNA binding
D1816_RS25065	COG0336	Belongs to the RNA methyltransferase TrmD family
D1816_RS25080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1816_RS25085	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1816_RS25090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1816_RS25095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1816_RS25105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1816_RS25110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1816_RS25115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1816_RS25125	COG1739	Uncharacterized protein family UPF0029
D1816_RS25135	COG1011	Hydrolase
D1816_RS25140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1816_RS25140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1816_RS25155	COG2890	protein-(glutamine-N5) methyltransferase activity
D1816_RS25165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1816_RS25200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1816_RS25230	COG0497	DNA recombination
D1816_RS25235	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1816_RS25240	COG1216	Glycosyl transferase, family 2
D1816_RS25240	COG0463	Glycosyl transferase, family 2
D1816_RS25250	COG0237	dephospho-CoA kinase activity
D1816_RS25265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1816_RS25270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1816_RS25280	COG0322	excinuclease ABC activity
D1816_RS25285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1816_RS25295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS25300	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1816_RS25305	COG0673	inositol 2-dehydrogenase activity
D1816_RS25315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1816_RS25320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1816_RS25365	COG0542	response to heat
D1816_RS25385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1816_RS25410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1816_RS25415	COG0667	Aldo Keto reductase
D1816_RS25420	COG3279	Response regulator of the LytR AlgR family
D1816_RS25425	COG2972	Histidine kinase
D1816_RS25435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1816_RS25465	COG1132	(ABC) transporter
D1816_RS25480	COG1988	membrane-bound metal-dependent