locus-tag	class	description
D1818_RS00065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1818_RS00075	COG1454	alcohol dehydrogenase
D1818_RS00090	COG0217	transcriptional regulatory protein
D1818_RS00095	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1818_RS00105	COG0424	maF-like protein
D1818_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1818_RS00155	COG1295	ribonuclease BN
D1818_RS00180	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1818_RS00190	COG3279	Response regulator of the LytR AlgR family
D1818_RS00195	COG0360	Binds together with S18 to 16S ribosomal RNA
D1818_RS00200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D1818_RS00205	COG0359	binds to the 23S rRNA
D1818_RS00220	COG0577	efflux transmembrane transporter activity
D1818_RS00225	COG0124	histidyl-tRNA synthetase
D1818_RS00275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1818_RS00280	COG1678	Uncharacterized ACR, COG1678
D1818_RS00290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D1818_RS00295	COG0514	ATP-dependent DNA helicase (RecQ)
D1818_RS00315	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1818_RS00320	COG0746	molybdenum cofactor guanylyltransferase activity
D1818_RS00335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D1818_RS00340	COG0513	Belongs to the DEAD box helicase family
D1818_RS00350	COG0745	RESPONSE REGULATOR receiver
D1818_RS00365	COG1960	acyl-CoA dehydrogenase activity
D1818_RS00370	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS00400	COG1024	Enoyl-CoA hydratase
D1818_RS00405	COG2130	NADP-dependent
D1818_RS00410	COG0604	alcohol dehydrogenase
D1818_RS00415	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS00440	COG2267	carboxylic ester hydrolase activity
D1818_RS00460	COG0010	Belongs to the arginase family
D1818_RS00465	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1818_RS00475	COG2986	histidine ammonia-lyase
D1818_RS00480	COG0583	DNA-binding transcription factor activity
D1818_RS00495	COG0415	Belongs to the DNA photolyase family
D1818_RS00510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1818_RS00520	COG0673	inositol 2-dehydrogenase activity
D1818_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS00545	COG2205	protein histidine kinase activity
D1818_RS00545	COG0784	Response regulator, receiver
D1818_RS00555	COG2885	chlorophyll binding
D1818_RS00560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1818_RS00565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1818_RS00575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1818_RS00585	COG0131	Imidazoleglycerol-phosphate dehydratase
D1818_RS00600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1818_RS00610	COG0107	imidazoleglycerol-phosphate synthase activity
D1818_RS00615	COG0140	phosphoribosyl-ATP diphosphatase activity
D1818_RS00615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1818_RS00635	COG0539	negative regulation of cytoplasmic translation
D1818_RS00640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1818_RS00645	COG0540	Belongs to the ATCase OTCase family
D1818_RS00655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1818_RS00660	COG1234	tRNA 3'-trailer cleavage
D1818_RS00670	COG0259	pyridoxamine-phosphate oxidase activity
D1818_RS00685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1818_RS00750	COG0438	transferase activity, transferring glycosyl groups
D1818_RS00775	COG0277	FAD linked oxidase domain protein
D1818_RS00775	COG0247	lactate metabolic process
D1818_RS00790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1818_RS00800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1818_RS00815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1818_RS00820	COG2610	gluconate transmembrane transporter activity
D1818_RS00860	COG1733	regulation of RNA biosynthetic process
D1818_RS00875	COG1522	sequence-specific DNA binding
D1818_RS00905	COG1280	lysine exporter protein (LysE YggA)
D1818_RS00950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1818_RS00955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1818_RS00960	COG1301	dicarboxylic acid transport
D1818_RS00965	COG0076	glutamate decarboxylase activity
D1818_RS00975	COG3275	phosphorelay sensor kinase activity
D1818_RS01000	COG1629	transport
D1818_RS01010	COG3011	Protein conserved in bacteria
D1818_RS01020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1818_RS01080	COG2827	Endonuclease containing a URI domain
D1818_RS01095	COG2827	Endonuclease containing a URI domain
D1818_RS01115	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D1818_RS01125	COG0732	type I restriction modification DNA specificity domain
D1818_RS01135	COG1401	restriction endodeoxyribonuclease activity
D1818_RS01190	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1818_RS01195	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D1818_RS01235	COG3279	Response regulator of the LytR AlgR family
D1818_RS01265	COG1012	belongs to the aldehyde dehydrogenase family
D1818_RS01270	COG4221	oxidoreductase activity
D1818_RS01310	COG4771	TonB-dependent receptor
D1818_RS01350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1818_RS01355	COG0251	oxidation-reduction process
D1818_RS01360	COG0083	homoserine kinase activity
D1818_RS01365	COG0460	homoserine dehydrogenase
D1818_RS01365	COG0527	aspartate kinase activity
D1818_RS01370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1818_RS01390	COG4974	Belongs to the 'phage' integrase family
D1818_RS01435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1818_RS01445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1818_RS01450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1818_RS01480	COG0640	Transcriptional regulator
D1818_RS01495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1818_RS01505	COG2823	Periplasmic or secreted lipoprotein
D1818_RS01505	COG1652	LysM domain
D1818_RS01515	COG2258	MOSC domain
D1818_RS01520	COG2072	flavoprotein involved in K transport
D1818_RS01530	COG0514	ATP-dependent DNA helicase (RecQ)
D1818_RS01555	COG1523	belongs to the glycosyl hydrolase 13 family
D1818_RS01565	COG1045	serine acetyltransferase
D1818_RS01570	COG0517	IMP dehydrogenase activity
D1818_RS01570	COG0516	GMP reductase activity
D1818_RS01580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1818_RS01590	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS01595	COG1309	transcriptional regulator
D1818_RS01630	COG0791	NLP P60 protein
D1818_RS01635	COG0183	Belongs to the thiolase family
D1818_RS01640	COG1480	7TM receptor with intracellular HD hydrolase
D1818_RS01655	COG0668	transmembrane transport
D1818_RS01680	COG0366	Alpha amylase catalytic
D1818_RS01690	COG1575	Belongs to the MenA family. Type 1 subfamily
D1818_RS01695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1818_RS01700	COG4948	Mandelate Racemase Muconate Lactonizing
D1818_RS01705	COG1266	CAAX protease self-immunity
D1818_RS01760	COG2304	oxidoreductase activity
D1818_RS01780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1818_RS01795	COG0488	(ABC) transporter
D1818_RS01820	COG1187	pseudouridine synthase activity
D1818_RS01845	COG0659	secondary active sulfate transmembrane transporter activity
D1818_RS01900	COG3012	SEC-C Motif Domain Protein
D1818_RS01915	COG0641	radical SAM
D1818_RS01925	COG1741	Belongs to the pirin family
D1818_RS01935	COG2378	regulation of single-species biofilm formation
D1818_RS01950	COG0297	glycogen (starch) synthase activity
D1818_RS01955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1818_RS01960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1818_RS02025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1818_RS02030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1818_RS02035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1818_RS02055	COG2814	Major facilitator Superfamily
D1818_RS02080	COG0352	thiamine-phosphate diphosphorylase activity
D1818_RS02120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D1818_RS02170	COG2217	Heavy metal translocating P-type atpase
D1818_RS02200	COG1999	signal sequence binding
D1818_RS02235	COG1024	Enoyl-CoA hydratase
D1818_RS02250	COG0300	oxidoreductase activity
D1818_RS02270	COG0523	cobalamin synthesis protein
D1818_RS02275	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1818_RS02325	COG2972	Histidine kinase
D1818_RS02330	COG3279	Response regulator of the LytR AlgR family
D1818_RS02345	COG1794	racemase activity, acting on amino acids and derivatives
D1818_RS02350	COG0583	DNA-binding transcription factor activity
D1818_RS02380	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1818_RS02410	COG1278	Cold shock
D1818_RS02435	COG0784	Response regulator, receiver
D1818_RS02435	COG2198	Histidine kinase
D1818_RS02435	COG5002	protein histidine kinase activity
D1818_RS02440	COG1979	alcohol dehydrogenase
D1818_RS02465	COG4206	TonB-dependent receptor
D1818_RS02465	COG1629	transport
D1818_RS02475	COG3279	Response regulator of the LytR AlgR family
D1818_RS02480	COG3275	phosphorelay sensor kinase activity
D1818_RS02490	COG1131	(ABC) transporter
D1818_RS02515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D1818_RS02600	COG2972	Histidine kinase
D1818_RS02605	COG3279	Response regulator of the LytR AlgR family
D1818_RS02640	COG1012	belongs to the aldehyde dehydrogenase family
D1818_RS02655	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D1818_RS02660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1818_RS02665	COG0545	Peptidyl-prolyl cis-trans isomerase
D1818_RS02715	COG1595	DNA-templated transcription, initiation
D1818_RS02725	COG0784	Response regulator, receiver
D1818_RS02725	COG2205	protein histidine kinase activity
D1818_RS02765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D1818_RS02770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1818_RS02775	COG1595	DNA-templated transcription, initiation
D1818_RS02810	COG1086	Polysaccharide biosynthesis protein
D1818_RS02815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1818_RS02820	COG1696	Membrane protein involved in D-alanine export
D1818_RS02845	COG1045	serine acetyltransferase
D1818_RS02850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1818_RS02870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1818_RS02910	COG0438	transferase activity, transferring glycosyl groups
D1818_RS02965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1818_RS02970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1818_RS02980	COG0022	dehydrogenase e1 component
D1818_RS03000	COG0813	purine-nucleoside phosphorylase activity
D1818_RS03005	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D1818_RS03030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1818_RS03035	COG1193	negative regulation of DNA recombination
D1818_RS03065	COG0612	Peptidase, M16
D1818_RS03070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D1818_RS03080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1818_RS03085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1818_RS03090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1818_RS03095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1818_RS03095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D1818_RS03100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1818_RS03105	COG1078	dGTPase activity
D1818_RS03110	COG2204	response regulator
D1818_RS03130	COG0686	Belongs to the AlaDH PNT family
D1818_RS03145	COG3813	Protein conserved in bacteria
D1818_RS03155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1818_RS03160	COG4771	TonB-dependent receptor
D1818_RS03165	COG0702	epimerase
D1818_RS03180	COG0010	Belongs to the arginase family
D1818_RS03210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1818_RS03230	COG0471	metal ion transport
D1818_RS03240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1818_RS03245	COG1611	Belongs to the LOG family
D1818_RS03265	COG0022	dehydrogenase e1 component
D1818_RS03290	COG2996	Protein conserved in bacteria
D1818_RS03300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D1818_RS03305	COG1169	isochorismate synthase
D1818_RS03345	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D1818_RS03385	COG0793	Belongs to the peptidase S41A family
D1818_RS03415	COG0702	epimerase
D1818_RS03435	COG4977	sequence-specific DNA binding
D1818_RS03480	COG1595	DNA-templated transcription, initiation
D1818_RS03485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1818_RS03490	COG1522	sequence-specific DNA binding
D1818_RS03510	COG0861	Integral membrane protein TerC family
D1818_RS03515	COG2824	Alkylphosphonate utilization operon protein PhnA
D1818_RS03540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D1818_RS03555	COG1233	COG1233 Phytoene dehydrogenase and related
D1818_RS03560	COG2326	polyphosphate kinase activity
D1818_RS03565	COG2326	polyphosphate kinase activity
D1818_RS03580	COG1506	peptidase
D1818_RS03585	COG0784	Response regulator, receiver
D1818_RS03585	COG2198	Histidine kinase
D1818_RS03585	COG2205	protein histidine kinase activity
D1818_RS03595	COG0012	GTP binding
D1818_RS03620	COG4771	TonB-dependent receptor
D1818_RS03640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1818_RS03650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1818_RS03655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1818_RS03680	COG0302	gtp cyclohydrolase
D1818_RS03685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1818_RS03695	COG1136	(ABC) transporter
D1818_RS03710	COG1858	cytochrome C peroxidase
D1818_RS03720	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D1818_RS03730	COG3361	conserved protein (COG2071)
D1818_RS03745	COG0513	Belongs to the DEAD box helicase family
D1818_RS03760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1818_RS03810	COG2207	Transcriptional regulator
D1818_RS03810	COG3708	Transcriptional regulator
D1818_RS03815	COG1501	Belongs to the glycosyl hydrolase 31 family
D1818_RS03865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1818_RS03870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1818_RS03880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1818_RS03940	COG2186	Transcriptional regulator
D1818_RS03945	COG4771	TonB-dependent receptor
D1818_RS03950	COG0702	epimerase
D1818_RS03965	COG0156	8-amino-7-oxononanoate synthase activity
D1818_RS03975	COG1770	oligopeptidase
D1818_RS03980	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1818_RS03990	COG3422	double-strand break repair
D1818_RS04010	COG1393	Belongs to the ArsC family
D1818_RS04065	COG0626	cystathionine gamma-synthase activity
D1818_RS04115	COG0366	Alpha amylase catalytic
D1818_RS04120	COG3275	phosphorelay sensor kinase activity
D1818_RS04125	COG3279	Response regulator of the LytR AlgR family
D1818_RS04140	COG0009	L-threonylcarbamoyladenylate synthase
D1818_RS04145	COG0513	Belongs to the DEAD box helicase family
D1818_RS04150	COG1988	membrane-bound metal-dependent
D1818_RS04160	COG1132	(ABC) transporter
D1818_RS04190	COG2972	Histidine kinase
D1818_RS04195	COG3279	Response regulator of the LytR AlgR family
D1818_RS04200	COG0667	Aldo Keto reductase
D1818_RS04205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1818_RS04215	COG0519	Catalyzes the synthesis of GMP from XMP
D1818_RS04240	COG0300	oxidoreductase activity
D1818_RS04245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1818_RS04265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1818_RS04290	COG0542	response to heat
D1818_RS04300	COG2356	endonuclease I
D1818_RS04315	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1818_RS04345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D1818_RS04355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1818_RS04360	COG0673	inositol 2-dehydrogenase activity
D1818_RS04370	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1818_RS04375	COG4942	peptidase
D1818_RS04385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1818_RS04400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1818_RS04405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D1818_RS04430	COG0463	Glycosyl transferase, family 2
D1818_RS04430	COG1216	Glycosyl transferase, family 2
D1818_RS04435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1818_RS04440	COG0497	DNA recombination
D1818_RS04470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1818_RS04500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1818_RS04520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1818_RS04520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1818_RS04525	COG1011	Hydrolase
D1818_RS04535	COG1739	Uncharacterized protein family UPF0029
D1818_RS04550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D1818_RS04555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1818_RS04560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1818_RS04570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1818_RS04580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D1818_RS04585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1818_RS04600	COG0336	Belongs to the RNA methyltransferase TrmD family
D1818_RS04605	COG0335	large ribosomal subunit rRNA binding
D1818_RS04620	COG1595	DNA-templated transcription, initiation
D1818_RS04655	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D1818_RS04680	COG3209	COG3209 Rhs family protein
D1818_RS04680	COG4104	PAAR repeat-containing protein
D1818_RS04750	COG4999	Histidine kinase
D1818_RS04750	COG2205	protein histidine kinase activity
D1818_RS04750	COG3850	Histidine kinase
D1818_RS04750	COG3437	response regulator, receiver
D1818_RS04785	COG0587	DNA-directed DNA polymerase activity
D1818_RS04815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1818_RS04820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D1818_RS04825	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1818_RS04830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D1818_RS04840	COG2205	protein histidine kinase activity
D1818_RS04840	COG0784	Response regulator, receiver
D1818_RS04845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1818_RS04850	COG0501	Belongs to the peptidase M48B family
D1818_RS04855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1818_RS04860	COG0735	belongs to the Fur family
D1818_RS04865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1818_RS04920	COG2169	Transcriptional regulator
D1818_RS04920	COG1917	Cupin 2, conserved barrel domain protein
D1818_RS04930	COG1082	Xylose isomerase domain protein TIM barrel
D1818_RS04940	COG3119	arylsulfatase activity
D1818_RS04945	COG4771	TonB-dependent receptor
D1818_RS04950	COG0702	epimerase
D1818_RS04970	COG3119	arylsulfatase activity
D1818_RS04975	COG1472	Belongs to the glycosyl hydrolase 3 family
D1818_RS05005	COG3119	arylsulfatase activity
D1818_RS05015	COG3119	arylsulfatase activity
D1818_RS05025	COG2706	6-phosphogluconolactonase activity
D1818_RS05030	COG3250	beta-galactosidase activity
D1818_RS05045	COG3250	beta-galactosidase activity
D1818_RS05060	COG3119	arylsulfatase activity
D1818_RS05080	COG3250	beta-galactosidase activity
D1818_RS05085	COG3119	arylsulfatase activity
D1818_RS05090	COG3507	Belongs to the glycosyl hydrolase 43 family
D1818_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS05105	COG1063	alcohol dehydrogenase
D1818_RS05125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D1818_RS05150	COG2273	Hydrolase Family 16
D1818_RS05155	COG3401	FG-GAP repeat protein
D1818_RS05160	COG3408	Glycogen debranching enzyme
D1818_RS05160	COG3119	arylsulfatase activity
D1818_RS05180	COG1063	alcohol dehydrogenase
D1818_RS05185	COG0800	Aldolase
D1818_RS05190	COG2721	sulfolactate sulfo-lyase activity
D1818_RS05200	COG0246	Mannitol dehydrogenase
D1818_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS05215	COG0738	Major facilitator superfamily
D1818_RS05220	COG3254	rhamnose metabolic process
D1818_RS05225	COG3292	Two component regulator propeller
D1818_RS05225	COG0745	RESPONSE REGULATOR receiver
D1818_RS05225	COG2205	protein histidine kinase activity
D1818_RS05230	COG1070	Carbohydrate kinase
D1818_RS05235	COG2115	Belongs to the xylose isomerase family
D1818_RS05240	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1818_RS05250	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1818_RS05260	COG0633	Ferredoxin
D1818_RS05265	COG2124	cytochrome p450
D1818_RS05285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1818_RS05290	COG1331	Highly conserved protein containing a thioredoxin domain
D1818_RS05305	COG1271	oxidase subunit
D1818_RS05310	COG4585	Histidine kinase
D1818_RS05370	COG0366	Alpha amylase catalytic
D1818_RS05395	COG1473	amidohydrolase
D1818_RS05400	COG0069	glutamate synthase activity
D1818_RS05435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1818_RS05445	COG3279	Response regulator of the LytR AlgR family
D1818_RS05450	COG2205	protein histidine kinase activity
D1818_RS05465	COG4974	Belongs to the 'phage' integrase family
D1818_RS05535	COG0270	DNA (cytosine-5-)-methyltransferase activity
D1818_RS05675	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1818_RS05680	COG1595	DNA-templated transcription, initiation
D1818_RS05715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1818_RS05740	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D1818_RS05750	COG3275	phosphorelay sensor kinase activity
D1818_RS05755	COG3279	Response regulator of the LytR AlgR family
D1818_RS05765	COG0069	glutamate synthase activity
D1818_RS05765	COG0070	glutamate synthase
D1818_RS05765	COG0067	glutamate synthase
D1818_RS05770	COG0347	Belongs to the P(II) protein family
D1818_RS05775	COG0004	ammonium transporteR
D1818_RS05790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D1818_RS05865	COG2204	response regulator
D1818_RS05880	COG1136	(ABC) transporter
D1818_RS05885	COG0577	efflux transmembrane transporter activity
D1818_RS05895	COG0577	efflux transmembrane transporter activity
D1818_RS05900	COG0577	efflux transmembrane transporter activity
D1818_RS05900	COG1136	(ABC) transporter
D1818_RS05920	COG0577	efflux transmembrane transporter activity
D1818_RS05920	COG1136	(ABC) transporter
D1818_RS05930	COG1136	(ABC) transporter
D1818_RS05935	COG1538	Outer membrane efflux protein
D1818_RS05945	COG1404	Belongs to the peptidase S8 family
D1818_RS06050	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1818_RS06085	COG0714	Associated with various cellular activities
D1818_RS06100	COG0312	modulator of DNA gyrase
D1818_RS06120	COG1573	uracil-dna glycosylase
D1818_RS06140	COG4251	negative regulation of phosphorylation
D1818_RS06150	COG2201	protein-glutamate methylesterase activity
D1818_RS06155	COG2201	protein-glutamate methylesterase activity
D1818_RS06195	COG0439	Biotin carboxylase
D1818_RS06200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1818_RS06230	COG2211	Major facilitator Superfamily
D1818_RS06235	COG0673	inositol 2-dehydrogenase activity
D1818_RS06260	COG0165	Argininosuccinate lyase
D1818_RS06270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1818_RS06275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1818_RS06290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1818_RS06295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1818_RS06300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1818_RS06305	COG0137	argininosuccinate synthase activity
D1818_RS06320	COG2186	Transcriptional regulator
D1818_RS06325	COG4771	TonB-dependent receptor
D1818_RS06330	COG0702	epimerase
D1818_RS06350	COG1917	Cupin 2, conserved barrel domain protein
D1818_RS06355	COG2271	Major facilitator Superfamily
D1818_RS06370	COG0800	Aldolase
D1818_RS06450	COG2274	protein secretion by the type I secretion system
D1818_RS06470	COG2264	protein methyltransferase activity
D1818_RS06480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1818_RS06485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D1818_RS06500	COG0730	response to heat
D1818_RS06520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1818_RS06525	COG0747	negative chemotaxis
D1818_RS06540	COG0254	rRNA binding
D1818_RS06565	COG0463	Glycosyl transferase, family 2
D1818_RS06570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1818_RS06575	COG1132	(ABC) transporter
D1818_RS06580	COG1595	DNA-templated transcription, initiation
D1818_RS06600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1818_RS06600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1818_RS06620	COG1022	Amp-dependent synthetase and ligase
D1818_RS06625	COG1846	Transcriptional regulator
D1818_RS06630	COG1024	Enoyl-CoA hydratase
D1818_RS06630	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1818_RS06640	COG0183	Belongs to the thiolase family
D1818_RS06645	COG1960	acyl-CoA dehydrogenase activity
D1818_RS06670	COG1629	transport
D1818_RS06670	COG4206	TonB-dependent receptor
D1818_RS06690	COG3387	PFAM Glycoside hydrolase 15-related
D1818_RS06695	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D1818_RS06790	COG2819	hydrolase of the alpha beta superfamily
D1818_RS06820	COG0488	(ABC) transporter
D1818_RS06865	COG2267	carboxylic ester hydrolase activity
D1818_RS06885	COG2205	protein histidine kinase activity
D1818_RS06885	COG0784	Response regulator, receiver
D1818_RS06890	COG3437	response regulator, receiver
D1818_RS06890	COG3850	Histidine kinase
D1818_RS06890	COG4999	Histidine kinase
D1818_RS06890	COG2205	protein histidine kinase activity
D1818_RS06950	COG1335	isochorismatase
D1818_RS07040	COG2345	Transcriptional regulator
D1818_RS07145	COG0659	secondary active sulfate transmembrane transporter activity
D1818_RS07200	COG1595	DNA-templated transcription, initiation
D1818_RS07260	COG1191	sigma factor activity
D1818_RS07265	COG1252	NADH dehydrogenase
D1818_RS07290	COG3275	phosphorelay sensor kinase activity
D1818_RS07315	COG3279	Response regulator of the LytR AlgR family
D1818_RS07345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1818_RS07375	COG0714	Associated with various cellular activities
D1818_RS07450	COG0492	ferredoxin-NADP+ reductase activity
D1818_RS07475	COG2860	membrane
D1818_RS07495	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1818_RS07540	COG1215	transferase activity, transferring glycosyl groups
D1818_RS07600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1818_RS07620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1818_RS07635	COG1874	Beta-galactosidase
D1818_RS07635	COG0366	Alpha amylase catalytic
D1818_RS07650	COG1629	transport
D1818_RS07650	COG4206	TonB-dependent receptor
D1818_RS07665	COG3956	TIGRFAM MazG family protein
D1818_RS07675	COG0463	Glycosyl transferase, family 2
D1818_RS07690	COG0482	sulfurtransferase activity
D1818_RS07700	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1818_RS07705	COG0706	membrane insertase activity
D1818_RS07710	COG0504	CTP synthase activity
D1818_RS07725	COG0242	peptide deformylase activity
D1818_RS07735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1818_RS07740	COG2171	N-acyltransferase activity
D1818_RS07750	COG0463	Glycosyl transferase, family 2
D1818_RS07750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D1818_RS07755	COG0463	Glycosyl transferase, family 2
D1818_RS07765	COG1216	Glycosyl transferase, family 2
D1818_RS07790	COG0009	L-threonylcarbamoyladenylate synthase
D1818_RS07795	COG0617	tRNA 3'-terminal CCA addition
D1818_RS07835	COG1131	(ABC) transporter
D1818_RS07860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1818_RS07865	COG0259	pyridoxamine-phosphate oxidase activity
D1818_RS07885	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D1818_RS07910	COG3279	Response regulator of the LytR AlgR family
D1818_RS07915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1818_RS07940	COG0071	Belongs to the small heat shock protein (HSP20) family
D1818_RS08005	COG0167	dihydroorotate dehydrogenase activity
D1818_RS08010	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1818_RS08015	COG0668	transmembrane transport
D1818_RS08020	COG1862	Preprotein translocase
D1818_RS08030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1818_RS08040	COG1132	(ABC) transporter
D1818_RS08080	COG2318	DinB family
D1818_RS08090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1818_RS08130	COG0514	ATP-dependent DNA helicase (RecQ)
D1818_RS08135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1818_RS08135	COG0517	IMP dehydrogenase activity
D1818_RS08140	COG0805	protein transport
D1818_RS08150	COG1137	ATPase activity
D1818_RS08155	COG2843	Capsule synthesis protein
D1818_RS08170	COG1183	phosphatidylcholine synthase activity
D1818_RS08180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1818_RS08185	COG0488	(ABC) transporter
D1818_RS08195	COG1136	(ABC) transporter
D1818_RS08215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1818_RS08235	COG0326	Molecular chaperone. Has ATPase activity
D1818_RS08240	COG2197	response regulator
D1818_RS08325	COG2267	carboxylic ester hydrolase activity
D1818_RS08330	COG0561	phosphatase activity
D1818_RS08365	COG1482	cell wall glycoprotein biosynthetic process
D1818_RS08370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1818_RS08380	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1818_RS08385	COG2885	chlorophyll binding
D1818_RS08400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D1818_RS08415	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1818_RS08420	COG0085	RNA polymerase activity
D1818_RS08425	COG0222	ribosome binding
D1818_RS08430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1818_RS08435	COG0081	regulation of translation
D1818_RS08440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1818_RS08490	COG4974	Belongs to the 'phage' integrase family
D1818_RS08495	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1818_RS08510	COG1960	acyl-CoA dehydrogenase activity
D1818_RS08520	COG1115	amino acid carrier protein
D1818_RS08525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1818_RS08540	COG2207	Transcriptional regulator
D1818_RS08550	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1818_RS08555	COG3876	Protein conserved in bacteria
D1818_RS08560	COG4585	Histidine kinase
D1818_RS08565	COG2197	response regulator
D1818_RS08620	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D1818_RS08645	COG0564	pseudouridine synthase activity
D1818_RS08650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1818_RS08655	COG4977	sequence-specific DNA binding
D1818_RS08655	COG1917	Cupin 2, conserved barrel domain protein
D1818_RS08670	COG0739	heme binding
D1818_RS08695	COG2884	Cell division ATP-binding protein ftsE
D1818_RS08715	COG1216	Glycosyl transferase, family 2
D1818_RS08715	COG0463	Glycosyl transferase, family 2
D1818_RS08725	COG0438	transferase activity, transferring glycosyl groups
D1818_RS08750	COG1217	gtp-binding protein TYPA
D1818_RS08755	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D1818_RS08770	COG4206	TonB-dependent receptor
D1818_RS08770	COG1629	transport
D1818_RS08810	COG4452	Inner membrane protein CreD
D1818_RS08840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1818_RS08850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1818_RS08865	COG0187	DNA topoisomerase II activity
D1818_RS08875	COG0367	asparagine synthase
D1818_RS08885	COG0602	queuosine metabolic process
D1818_RS08890	COG0251	oxidation-reduction process
D1818_RS08895	COG0433	COG0433 Predicted ATPase
D1818_RS08905	COG0662	Cupin 2, conserved barrel domain protein
D1818_RS08905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1818_RS08915	COG1187	pseudouridine synthase activity
D1818_RS08930	COG1012	belongs to the aldehyde dehydrogenase family
D1818_RS08935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1818_RS08950	COG0656	L-ascorbic acid biosynthetic process
D1818_RS08955	COG0492	ferredoxin-NADP+ reductase activity
D1818_RS08995	COG2207	Transcriptional regulator
D1818_RS08995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1818_RS09000	COG3844	kynureninase activity
D1818_RS09045	COG1404	Belongs to the peptidase S8 family
D1818_RS09050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1818_RS09075	COG3340	Belongs to the peptidase S51 family
D1818_RS09080	COG2066	Belongs to the glutaminase family
D1818_RS09100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1818_RS09105	COG0463	Glycosyl transferase, family 2
D1818_RS09110	COG0456	acetyltransferase
D1818_RS09165	COG0740	serine-type endopeptidase activity
D1818_RS09180	COG4783	chaperone-mediated protein folding
D1818_RS09190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D1818_RS09235	COG3275	phosphorelay sensor kinase activity
D1818_RS09240	COG3279	Response regulator of the LytR AlgR family
D1818_RS09245	COG1477	protein flavinylation
D1818_RS09265	COG2197	response regulator
D1818_RS09290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1818_RS09295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1818_RS09300	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1818_RS09305	COG1805	sodium ion transport
D1818_RS09310	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1818_RS09320	COG5297	Belongs to the glycosyl hydrolase family 6
D1818_RS09330	COG2967	ApaG domain
D1818_RS09345	COG1012	belongs to the aldehyde dehydrogenase family
D1818_RS09375	COG0357	Ribosomal RNA small subunit methyltransferase G
D1818_RS09380	COG3239	Fatty acid desaturase
D1818_RS09385	COG0436	Aminotransferase
D1818_RS09395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1818_RS09400	COG0569	domain protein
D1818_RS09405	COG1073	alpha beta
D1818_RS09410	COG2226	methyltransferase
D1818_RS09430	COG0191	fructose-bisphosphate aldolase activity
D1818_RS09435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D1818_RS09450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1818_RS09455	COG1185	polyribonucleotide nucleotidyltransferase activity
D1818_RS09510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1818_RS09530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1818_RS09535	COG0492	ferredoxin-NADP+ reductase activity
D1818_RS09565	COG0456	acetyltransferase
D1818_RS09575	COG1254	Belongs to the acylphosphatase family
D1818_RS09585	COG0813	purine-nucleoside phosphorylase activity
D1818_RS09590	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D1818_RS09620	COG4191	Histidine kinase
D1818_RS09635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1818_RS09660	COG2010	Cytochrome c
D1818_RS09670	COG3278	Belongs to the heme-copper respiratory oxidase family
D1818_RS09685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1818_RS09725	COG0259	pyridoxamine-phosphate oxidase activity
D1818_RS09730	COG2217	Heavy metal translocating P-type atpase
D1818_RS09750	COG0589	response to stress
D1818_RS09795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1818_RS09830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1818_RS09830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1818_RS09835	COG0730	response to heat
D1818_RS09850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1818_RS09930	COG0386	Belongs to the glutathione peroxidase family
D1818_RS09945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1818_RS09970	COG3608	succinylglutamate desuccinylase aspartoacylase
D1818_RS10010	COG1404	Belongs to the peptidase S8 family
D1818_RS10040	COG0523	cobalamin synthesis protein
D1818_RS10045	COG0737	Belongs to the 5'-nucleotidase family
D1818_RS10050	COG0737	Belongs to the 5'-nucleotidase family
D1818_RS10065	COG1136	(ABC) transporter
D1818_RS10075	COG0302	gtp cyclohydrolase
D1818_RS10135	COG1610	YqeY-like protein
D1818_RS10140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1818_RS10155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1818_RS10160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1818_RS10165	COG0772	Belongs to the SEDS family
D1818_RS10170	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D1818_RS10175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1818_RS10180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1818_RS10185	COG0768	penicillin binding
D1818_RS10195	COG0275	rRNA processing
D1818_RS10200	COG2001	Belongs to the MraZ family
D1818_RS10210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1818_RS10230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1818_RS10240	COG0358	DNA primase activity
D1818_RS10275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D1818_RS10285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1818_RS10290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1818_RS10315	COG1490	D-aminoacyl-tRNA deacylase activity
D1818_RS10320	COG1162	GTPase activity
D1818_RS10325	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D1818_RS10330	COG0287	Prephenate dehydrogenase
D1818_RS10335	COG0436	Aminotransferase
D1818_RS10340	COG1605	Chorismate mutase
D1818_RS10340	COG0077	Prephenate dehydratase
D1818_RS10345	COG0156	8-amino-7-oxononanoate synthase activity
D1818_RS10350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1818_RS10360	COG4555	ABC transporter
D1818_RS10385	COG0702	epimerase
D1818_RS10390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1818_RS10400	COG0646	methionine synthase
D1818_RS10400	COG1410	methionine synthase
D1818_RS10410	COG0492	ferredoxin-NADP+ reductase activity
D1818_RS10415	COG1648	precorrin-2 dehydrogenase activity
D1818_RS10415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1818_RS10420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1818_RS10420	COG1648	precorrin-2 dehydrogenase activity
D1818_RS10425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1818_RS10435	COG0175	sulfate reduction
D1818_RS10470	COG1765	OsmC-like protein
D1818_RS10485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D1818_RS10550	COG1428	Deoxynucleoside kinase
D1818_RS10585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1818_RS10595	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1818_RS10600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1818_RS10605	COG2819	hydrolase of the alpha beta superfamily
D1818_RS10615	COG0596	Alpha beta hydrolase
D1818_RS10620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D1818_RS10630	COG3275	phosphorelay sensor kinase activity
D1818_RS10640	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1818_RS10650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1818_RS10675	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D1818_RS10690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D1818_RS10695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1818_RS10705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D1818_RS10710	COG2086	electron transfer activity
D1818_RS10715	COG0022	dehydrogenase e1 component
D1818_RS10715	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1818_RS10725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1818_RS10730	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D1818_RS10815	COG3279	Response regulator of the LytR AlgR family
D1818_RS10835	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS10845	COG1063	alcohol dehydrogenase
D1818_RS10865	COG3119	arylsulfatase activity
D1818_RS10880	COG4974	Belongs to the 'phage' integrase family
D1818_RS10885	COG1770	oligopeptidase
D1818_RS10900	COG1404	Belongs to the peptidase S8 family
D1818_RS10910	COG1505	serine-type exopeptidase activity
D1818_RS11075	COG1570	exodeoxyribonuclease VII activity
D1818_RS11080	COG2003	Belongs to the UPF0758 family
D1818_RS11145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1818_RS11155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1818_RS11170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1818_RS11170	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1818_RS11220	COG0076	glutamate decarboxylase activity
D1818_RS11240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1818_RS11250	COG0544	peptidyl-prolyl cis-trans isomerase activity
D1818_RS11255	COG1950	PFAM Membrane protein of
D1818_RS11270	COG0596	Alpha beta hydrolase
D1818_RS11275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D1818_RS11285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1818_RS11295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1818_RS11315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D1818_RS11325	COG3279	Response regulator of the LytR AlgR family
D1818_RS11330	COG3275	phosphorelay sensor kinase activity
D1818_RS11365	COG1214	PFAM Peptidase M22, glycoprotease
D1818_RS11370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1818_RS11380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1818_RS11385	COG1136	(ABC) transporter
D1818_RS11385	COG0577	efflux transmembrane transporter activity
D1818_RS11390	COG1136	(ABC) transporter
D1818_RS11390	COG0577	efflux transmembrane transporter activity
D1818_RS11395	COG1136	(ABC) transporter
D1818_RS11410	COG2322	membrane
D1818_RS11415	COG1999	signal sequence binding
D1818_RS11435	COG1845	cytochrome c oxidase, subunit III
D1818_RS11440	COG0109	protoheme IX farnesyltransferase activity
D1818_RS11465	COG0509	glycine decarboxylation via glycine cleavage system
D1818_RS11475	COG0632	four-way junction helicase activity
D1818_RS11495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1818_RS11505	COG2255	four-way junction helicase activity
D1818_RS11515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1818_RS11520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1818_RS11540	COG3743	rRNA binding
D1818_RS11540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1818_RS11545	COG0437	4 iron, 4 sulfur cluster binding
D1818_RS11560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D1818_RS11565	COG0195	Participates in both transcription termination and antitermination
D1818_RS11570	COG0779	Required for maturation of 30S ribosomal subunits
D1818_RS11595	COG3118	belongs to the thioredoxin family
D1818_RS11605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1818_RS11605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1818_RS11610	COG1253	flavin adenine dinucleotide binding
D1818_RS11640	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1818_RS11645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1818_RS11650	COG0052	Belongs to the universal ribosomal protein uS2 family
D1818_RS11655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1818_RS11660	COG0528	UMP kinase activity
D1818_RS11665	COG0233	cytoplasmic translational termination
D1818_RS11680	COG0017	Asparaginyl-tRNA synthetase
D1818_RS11700	COG3275	phosphorelay sensor kinase activity
D1818_RS11715	COG1396	sequence-specific DNA binding
D1818_RS11725	COG1842	Phage shock protein A
D1818_RS11730	COG0393	Putative heavy-metal-binding
D1818_RS11765	COG2255	four-way junction helicase activity
D1818_RS11785	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D1818_RS11820	COG4585	Histidine kinase
D1818_RS11825	COG2197	response regulator
D1818_RS11830	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D1818_RS11850	COG0848	biopolymer transport protein
D1818_RS11860	COG0848	biopolymer transport protein
D1818_RS11870	COG0811	peptide transport
D1818_RS11880	COG0252	asparaginase activity
D1818_RS11885	COG0084	hydrolase, TatD family'
D1818_RS11950	COG1136	(ABC) transporter
D1818_RS11950	COG0577	efflux transmembrane transporter activity
D1818_RS11955	COG0138	bifunctional purine biosynthesis protein purh
D1818_RS11960	COG1077	Cell shape determining protein MreB Mrl
D1818_RS11980	COG0772	Belongs to the SEDS family
D1818_RS12035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1818_RS12040	COG0793	Belongs to the peptidase S41A family
D1818_RS12045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D1818_RS12055	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1818_RS12060	COG0791	NLP P60 protein
D1818_RS12070	COG0658	competence protein
D1818_RS12070	COG2333	competence protein COMEC
D1818_RS12095	COG3104	oligopeptide transport
D1818_RS12100	COG0823	Involved in the tonB-independent uptake of proteins
D1818_RS12100	COG1506	peptidase
D1818_RS12115	COG3291	Pkd domain containing protein
D1818_RS12125	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1818_RS12160	COG1309	transcriptional regulator
D1818_RS12185	COG4771	TonB-dependent receptor
D1818_RS12190	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1818_RS12200	COG0366	Alpha amylase catalytic
D1818_RS12210	COG1278	Cold shock
D1818_RS12235	COG0590	tRNA wobble adenosine to inosine editing
D1818_RS12240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1818_RS12245	COG1404	Belongs to the peptidase S8 family
D1818_RS12250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D1818_RS12300	COG2095	MarC family integral membrane protein
D1818_RS12335	COG0668	transmembrane transport
D1818_RS12340	COG1904	glucuronate isomerase
D1818_RS12345	COG3250	beta-galactosidase activity
D1818_RS12350	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D1818_RS12355	COG0702	epimerase
D1818_RS12360	COG4771	TonB-dependent receptor
D1818_RS12365	COG0745	RESPONSE REGULATOR receiver
D1818_RS12365	COG2205	protein histidine kinase activity
D1818_RS12365	COG3292	Two component regulator propeller
D1818_RS12370	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS12375	COG1312	Catalyzes the dehydration of D-mannonate
D1818_RS12380	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D1818_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS12400	COG0800	Aldolase
D1818_RS12405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D1818_RS12455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1818_RS12475	COG0473	3-isopropylmalate dehydrogenase activity
D1818_RS12500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1818_RS12505	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D1818_RS12510	COG0193	aminoacyl-tRNA hydrolase activity
D1818_RS12515	COG0196	riboflavin kinase activity
D1818_RS12525	COG4585	Histidine kinase
D1818_RS12555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1818_RS12585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1818_RS12590	COG2239	Acts as a magnesium transporter
D1818_RS12620	COG3179	chitinase
D1818_RS12625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1818_RS12635	COG2197	response regulator
D1818_RS12660	COG1846	Transcriptional regulator
D1818_RS12680	COG1247	-acetyltransferase
D1818_RS12685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1818_RS12690	COG0668	transmembrane transport
D1818_RS12700	COG0460	homoserine dehydrogenase
D1818_RS12700	COG0527	aspartate kinase activity
D1818_RS12710	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D1818_RS12730	COG2205	protein histidine kinase activity
D1818_RS12730	COG0784	Response regulator, receiver
D1818_RS12740	COG1793	dna ligase
D1818_RS12740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1818_RS12745	COG1793	dna ligase
D1818_RS12750	COG1201	RNA secondary structure unwinding
D1818_RS12760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1818_RS12770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1818_RS12840	COG0667	Aldo Keto reductase
D1818_RS12845	COG0792	nuclease activity
D1818_RS12850	COG1619	proteins homologs of microcin C7 resistance protein MccF
D1818_RS12875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1818_RS12875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1818_RS12895	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1818_RS12900	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1818_RS12940	COG1053	succinate dehydrogenase
D1818_RS12960	COG0436	Aminotransferase
D1818_RS12970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1818_RS13000	COG2954	triphosphatase activity
D1818_RS13015	COG4953	penicillin-binding protein 1C
D1818_RS13045	COG2329	Antibiotic biosynthesis monooxygenase
D1818_RS13055	COG2373	Large extracellular alpha-helical protein
D1818_RS13145	COG1418	mRNA catabolic process
D1818_RS13220	COG1999	signal sequence binding
D1818_RS13225	COG0750	zinc metalloprotease
D1818_RS13240	COG4221	oxidoreductase activity
D1818_RS13250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1818_RS13255	COG4771	TonB-dependent receptor
D1818_RS13360	COG4771	TonB-dependent receptor
D1818_RS13365	COG1381	Involved in DNA repair and RecF pathway recombination
D1818_RS13375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1818_RS13380	COG0626	cystathionine gamma-synthase activity
D1818_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS13425	COG3781	membrane
D1818_RS13430	COG0429	hydrolase of the alpha beta-hydrolase fold
D1818_RS13455	COG0450	alkyl hydroperoxide reductase
D1818_RS13460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D1818_RS13465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1818_RS13470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1818_RS13480	COG1774	PSP1 C-terminal conserved region
D1818_RS13485	COG1054	Belongs to the UPF0176 family
D1818_RS13490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1818_RS13500	COG1595	DNA-templated transcription, initiation
D1818_RS13545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D1818_RS13590	COG1286	toxin biosynthetic process
D1818_RS13625	COG2304	oxidoreductase activity
D1818_RS13630	COG0655	NAD(P)H dehydrogenase (quinone) activity
D1818_RS13635	COG2304	oxidoreductase activity
D1818_RS13650	COG0714	Associated with various cellular activities
D1818_RS13655	COG4221	oxidoreductase activity
D1818_RS13705	COG3275	phosphorelay sensor kinase activity
D1818_RS13710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1818_RS13715	COG1253	flavin adenine dinucleotide binding
D1818_RS13740	COG0113	porphobilinogen synthase activity
D1818_RS13745	COG1131	(ABC) transporter
D1818_RS13820	COG0408	coproporphyrinogen oxidase activity
D1818_RS13825	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D1818_RS13835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D1818_RS13850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1818_RS13860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1818_RS13875	COG1981	membrane
D1818_RS13885	COG1561	YicC-like family, N-terminal region
D1818_RS13890	COG0194	GDP metabolic process
D1818_RS13895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D1818_RS13910	COG1024	Enoyl-CoA hydratase
D1818_RS13935	COG4260	virion core protein, lumpy skin disease virus
D1818_RS13960	COG1012	belongs to the aldehyde dehydrogenase family
D1818_RS13965	COG0662	Cupin 2, conserved barrel domain protein
D1818_RS13980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D1818_RS13985	COG4628	conserved protein (DUF2132)
D1818_RS14000	COG2897	thiosulfate sulfurtransferase activity
D1818_RS14015	COG0758	DNA mediated transformation
D1818_RS14015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D1818_RS14050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1818_RS14055	COG0756	dUTP diphosphatase activity
D1818_RS14085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1818_RS14090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1818_RS14095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1818_RS14100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1818_RS14105	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D1818_RS14110	COG0356	it plays a direct role in the translocation of protons across the membrane
D1818_RS14135	COG1136	(ABC) transporter
D1818_RS14150	COG2072	flavoprotein involved in K transport
D1818_RS14165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1818_RS14205	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D1818_RS14245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1818_RS14280	COG0151	Belongs to the GarS family
D1818_RS14285	COG3307	-O-antigen
D1818_RS14295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1818_RS14310	COG0438	transferase activity, transferring glycosyl groups
D1818_RS14320	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D1818_RS14350	COG2244	polysaccharide biosynthetic process
D1818_RS14360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1818_RS14370	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D1818_RS14395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1818_RS14410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1818_RS14415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D1818_RS14430	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D1818_RS14465	COG4942	peptidase
D1818_RS14470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1818_RS14495	COG1388	LysM domain
D1818_RS14495	COG0741	lytic transglycosylase activity
D1818_RS14500	COG0126	phosphoglycerate kinase activity
D1818_RS14505	COG0470	DNA polymerase III
D1818_RS14550	COG0445	tRNA wobble uridine modification
D1818_RS14555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D1818_RS14565	COG3239	Fatty acid desaturase
D1818_RS14570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1818_RS14575	COG0330	HflC and HflK could
D1818_RS14585	COG2194	sulfuric ester hydrolase activity
D1818_RS14590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1818_RS14615	COG0557	exoribonuclease II activity
D1818_RS14630	COG0698	ribose 5-phosphate isomerase
D1818_RS14640	COG2153	protein acetylation
D1818_RS14645	COG0793	Belongs to the peptidase S41A family
D1818_RS14650	COG0594	ribonuclease P activity
D1818_RS14665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1818_RS14680	COG0025	NhaP-type Na H and K H
D1818_RS14720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1818_RS14745	COG2151	metal-sulfur cluster biosynthetic enzyme
D1818_RS14750	COG2166	iron-sulfur cluster assembly
D1818_RS14755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1818_RS14775	COG0719	Fe-S assembly protein
D1818_RS14780	COG0396	ATPase activity
D1818_RS14790	COG0719	Fe-S assembly protein
D1818_RS14800	COG1858	cytochrome C peroxidase
D1818_RS14830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1818_RS14840	COG2267	carboxylic ester hydrolase activity
D1818_RS14860	COG0006	proline dipeptidase activity
D1818_RS14895	COG0469	pyruvate kinase activity
D1818_RS14905	COG0571	ribonuclease III activity
D1818_RS14910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1818_RS14915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1818_RS14920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1818_RS14925	COG3341	Caulimovirus viroplasmin
D1818_RS14925	COG0328	RNA-DNA hybrid ribonuclease activity
D1818_RS14950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D1818_RS14955	COG1074	ATP-dependent DNA helicase activity
D1818_RS15050	COG2115	Belongs to the xylose isomerase family
D1818_RS15055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1818_RS15060	COG2017	converts alpha-aldose to the beta-anomer
D1818_RS15065	COG1609	Transcriptional regulator
D1818_RS15085	COG3292	Two component regulator propeller
D1818_RS15085	COG2205	protein histidine kinase activity
D1818_RS15085	COG0745	RESPONSE REGULATOR receiver
D1818_RS15090	COG1472	Belongs to the glycosyl hydrolase 3 family
D1818_RS15095	COG1629	transport
D1818_RS15100	COG0561	phosphatase activity
D1818_RS15115	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D1818_RS15165	COG2885	chlorophyll binding
D1818_RS15200	COG0534	Mate efflux family protein
D1818_RS15210	COG0720	synthase
D1818_RS15215	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1818_RS15230	COG1505	serine-type exopeptidase activity
D1818_RS15245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1818_RS15250	COG1970	mechanosensitive ion channel activity
D1818_RS15255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1818_RS15260	COG1435	thymidine kinase activity
D1818_RS15275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1818_RS15300	COG4585	Histidine kinase
D1818_RS15305	COG2197	response regulator
D1818_RS15315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D1818_RS15315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1818_RS15325	COG0596	Alpha beta hydrolase
D1818_RS15345	COG3485	protocatechuate 3,4-dioxygenase
D1818_RS15350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1818_RS15360	COG0439	Biotin carboxylase
D1818_RS15365	COG0511	ligase activity, forming carbon-carbon bonds
D1818_RS15370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1818_RS15375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1818_RS15385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D1818_RS15405	COG0346	lactoylglutathione lyase activity
D1818_RS15410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D1818_RS15415	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1818_RS15425	COG0481	GTPase activity
D1818_RS15430	COG0561	phosphatase activity
D1818_RS15445	COG0432	Pfam Uncharacterised protein family UPF0047
D1818_RS15480	COG4771	TonB-dependent receptor
D1818_RS15485	COG0166	Belongs to the GPI family
D1818_RS15495	COG3483	tryptophan 2,3-dioxygenase activity
D1818_RS15505	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D1818_RS15515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1818_RS15525	COG0322	excinuclease ABC activity
D1818_RS15535	COG0189	ligase activity
D1818_RS15545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1818_RS15550	COG2201	protein-glutamate methylesterase activity
D1818_RS15555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D1818_RS15575	COG5662	AntiSigma factor
D1818_RS15580	COG1595	DNA-templated transcription, initiation
D1818_RS15585	COG3338	carbonate dehydratase activity
D1818_RS15600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1818_RS15605	COG4206	TonB-dependent receptor
D1818_RS15605	COG1629	transport
D1818_RS15630	COG1040	competence protein
D1818_RS15640	COG0423	glycine-tRNA ligase activity
D1818_RS15665	COG1131	(ABC) transporter
D1818_RS15680	COG0708	Exodeoxyribonuclease III
D1818_RS15715	COG0667	Aldo Keto reductase
D1818_RS15720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1818_RS15735	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D1818_RS15740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D1818_RS15745	COG0297	glycogen (starch) synthase activity
D1818_RS15755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1818_RS15760	COG4771	TonB-dependent receptor
D1818_RS15765	COG4771	TonB-dependent receptor
D1818_RS15810	COG0823	Involved in the tonB-independent uptake of proteins
D1818_RS15810	COG1506	peptidase
D1818_RS15810	COG4946	Tricorn protease homolog
D1818_RS15830	COG0156	8-amino-7-oxononanoate synthase activity
D1818_RS15835	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D1818_RS15840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1818_RS15855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1818_RS15860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1818_RS15905	COG2137	regulation of response to DNA damage stimulus
D1818_RS15945	COG1530	ribonuclease E activity
D1818_RS15950	COG0776	regulation of translation
D1818_RS15955	COG1194	a g-specific adenine glycosylase
D1818_RS15960	COG0629	single-stranded DNA binding
D1818_RS15985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1818_RS15990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D1818_RS16000	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1818_RS16030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1818_RS16040	COG2204	response regulator
D1818_RS16045	COG0784	Response regulator, receiver
D1818_RS16045	COG5002	protein histidine kinase activity
D1818_RS16060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1818_RS16075	COG2022	thiamine diphosphate biosynthetic process
D1818_RS16085	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D1818_RS16100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1818_RS16120	COG3852	Histidine kinase
D1818_RS16125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1818_RS16135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D1818_RS16140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1818_RS16145	COG0519	Catalyzes the synthesis of GMP from XMP
D1818_RS16150	COG4946	Tricorn protease homolog
D1818_RS16150	COG0793	Belongs to the peptidase S41A family
D1818_RS16165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1818_RS16170	COG1968	undecaprenyl-diphosphatase activity
D1818_RS16185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1818_RS16190	COG2177	Part of the ABC transporter FtsEX involved in
D1818_RS16195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1818_RS16205	COG0495	leucyl-tRNA aminoacylation
D1818_RS16225	COG1522	sequence-specific DNA binding
D1818_RS16235	COG2363	Small membrane protein
D1818_RS16240	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D1818_RS16255	COG0463	Glycosyl transferase, family 2
D1818_RS16260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1818_RS16290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1818_RS16320	COG0534	Mate efflux family protein
D1818_RS16330	COG4771	TonB-dependent receptor
D1818_RS16340	COG1629	transport
D1818_RS16355	COG0745	RESPONSE REGULATOR receiver
D1818_RS16360	COG5002	protein histidine kinase activity
D1818_RS16365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D1818_RS16370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D1818_RS16395	COG0489	protein tyrosine kinase activity
D1818_RS16435	COG0644	oxidoreductase
D1818_RS16465	COG0415	Belongs to the DNA photolyase family
D1818_RS16470	COG0583	DNA-binding transcription factor activity
D1818_RS16635	COG4977	sequence-specific DNA binding
D1818_RS16680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1818_RS16685	COG3938	Belongs to the proline racemase family
D1818_RS16695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1818_RS16705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D1818_RS16735	COG2226	methyltransferase
D1818_RS16740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1818_RS16745	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1818_RS16820	COG0228	four-way junction DNA binding
D1818_RS16825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D1818_RS16830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D1818_RS16840	COG1960	acyl-CoA dehydrogenase activity
D1818_RS16855	COG1280	lysine exporter protein (LysE YggA)
D1818_RS16860	COG1522	sequence-specific DNA binding
D1818_RS16865	COG0584	glycerophosphoryl diester phosphodiesterase
D1818_RS16870	COG2081	HI0933 family
D1818_RS16885	COG1309	transcriptional regulator
D1818_RS16890	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D1818_RS16925	COG1187	pseudouridine synthase activity
D1818_RS16930	COG3279	Response regulator of the LytR AlgR family
D1818_RS16965	COG1215	transferase activity, transferring glycosyl groups
D1818_RS16970	COG0463	Glycosyl transferase, family 2
D1818_RS16980	COG5002	protein histidine kinase activity
D1818_RS16995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1818_RS17055	COG2205	protein histidine kinase activity
D1818_RS17055	COG3292	Two component regulator propeller
D1818_RS17055	COG0745	RESPONSE REGULATOR receiver
D1818_RS17090	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1818_RS17090	COG1902	pentaerythritol trinitrate reductase activity
D1818_RS17100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1818_RS17110	COG1054	Belongs to the UPF0176 family
D1818_RS17125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1818_RS17130	COG1472	Belongs to the glycosyl hydrolase 3 family
D1818_RS17135	COG1472	Belongs to the glycosyl hydrolase 3 family
D1818_RS17150	COG1609	Transcriptional regulator
D1818_RS17155	COG0366	Alpha amylase catalytic
D1818_RS17160	COG4771	TonB-dependent receptor
D1818_RS17165	COG0702	epimerase
D1818_RS17200	COG1492	cobalamin metabolic process
D1818_RS17230	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D1818_RS17245	COG0778	Nitroreductase
D1818_RS17265	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D1818_RS17275	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D1818_RS17285	COG2096	Adenosyltransferase
D1818_RS17305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D1818_RS17330	COG1253	flavin adenine dinucleotide binding
D1818_RS17335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1818_RS17340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1818_RS17345	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1818_RS17350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1818_RS17365	COG0702	epimerase
D1818_RS17370	COG4771	TonB-dependent receptor
D1818_RS17375	COG1725	Transcriptional regulator
D1818_RS17385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D1818_RS17390	COG1085	galactose-1-phosphate uridylyltransferase
D1818_RS17405	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1818_RS17445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1818_RS17460	COG0459	protein refolding
D1818_RS17465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D1818_RS17485	COG3829	transcription factor binding
D1818_RS17490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1818_RS17500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1818_RS17500	COG1754	DNA topoisomerase type I activity
D1818_RS17510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1818_RS17540	COG0488	(ABC) transporter
D1818_RS17580	COG0066	3-isopropylmalate dehydratase activity
D1818_RS17585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1818_RS17650	COG4221	oxidoreductase activity
D1818_RS17665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1818_RS17665	COG2207	Transcriptional regulator
D1818_RS17670	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1818_RS17685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1818_RS17705	COG1902	pentaerythritol trinitrate reductase activity
D1818_RS17710	COG2423	ornithine cyclodeaminase activity
D1818_RS17730	COG1482	cell wall glycoprotein biosynthetic process
D1818_RS17735	COG0463	Glycosyl transferase, family 2
D1818_RS17780	COG0463	Glycosyl transferase, family 2
D1818_RS17800	COG3279	Response regulator of the LytR AlgR family
D1818_RS17810	COG3290	protein histidine kinase activity
D1818_RS17815	COG4251	negative regulation of phosphorylation
D1818_RS17825	COG0784	Response regulator, receiver
D1818_RS17825	COG2205	protein histidine kinase activity
D1818_RS17835	COG0784	Response regulator, receiver
D1818_RS17885	COG0076	glutamate decarboxylase activity
D1818_RS17890	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D1818_RS17915	COG2207	Transcriptional regulator
D1818_RS17920	COG4774	siderophore transport
D1818_RS17935	COG2205	protein histidine kinase activity
D1818_RS17935	COG2198	Histidine kinase
D1818_RS17935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1818_RS17935	COG0784	Response regulator, receiver
D1818_RS17985	COG3279	Response regulator of the LytR AlgR family
D1818_RS17990	COG0745	RESPONSE REGULATOR receiver
D1818_RS17990	COG2972	Histidine kinase
D1818_RS18005	COG1115	amino acid carrier protein
D1818_RS18020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1818_RS18035	COG1160	GTP binding
D1818_RS18060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1818_RS18120	COG3186	Phenylalanine-4-hydroxylase
D1818_RS18135	COG1309	transcriptional regulator
D1818_RS18140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1818_RS18145	COG3396	Phenylacetate-CoA oxygenase
D1818_RS18150	COG3460	Phenylacetate-CoA oxygenase
D1818_RS18160	COG3396	Phenylacetate-CoA oxygenase
D1818_RS18165	COG2151	metal-sulfur cluster biosynthetic enzyme
D1818_RS18175	COG1024	Enoyl-CoA hydratase
D1818_RS18180	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1818_RS18200	COG0183	Belongs to the thiolase family
D1818_RS18215	COG2030	dehydratase
D1818_RS18215	COG1012	belongs to the aldehyde dehydrogenase family
D1818_RS18230	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1818_RS18235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1818_RS18240	COG0022	dehydrogenase e1 component
D1818_RS18380	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D1818_RS18390	COG0464	growth
D1818_RS18420	COG1858	cytochrome C peroxidase
D1818_RS18425	COG1858	cytochrome C peroxidase
D1818_RS18455	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D1818_RS18460	COG1690	Belongs to the RtcB family
D1818_RS18520	COG3541	Predicted nucleotidyltransferase
D1818_RS18550	COG4585	Histidine kinase
D1818_RS18575	COG0069	glutamate synthase activity
D1818_RS18580	COG0629	single-stranded DNA binding
D1818_RS18625	COG1473	amidohydrolase
D1818_RS18640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1818_RS18660	COG3842	ATPase activity
D1818_RS18705	COG1388	LysM domain
D1818_RS18705	COG1705	Flagellar rod assembly protein muramidase FlgJ
D1818_RS18710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1818_RS18715	COG0784	Response regulator, receiver
D1818_RS18715	COG2205	protein histidine kinase activity
D1818_RS18745	COG4682	membrane
D1818_RS18790	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1818_RS18845	COG2197	response regulator
D1818_RS18850	COG0401	homolog of Blt101
D1818_RS18865	COG0321	lipoyl(octanoyl) transferase activity
D1818_RS18890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1818_RS18930	COG1960	acyl-CoA dehydrogenase activity
D1818_RS18940	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1818_RS18945	COG0811	peptide transport
D1818_RS18950	COG0848	biopolymer transport protein
D1818_RS18970	COG0668	transmembrane transport
D1818_RS18980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1818_RS18985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D1818_RS19000	COG0295	cytidine deaminase activity
D1818_RS19005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1818_RS19010	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1818_RS19025	COG4221	oxidoreductase activity
D1818_RS19045	COG2304	oxidoreductase activity
D1818_RS19055	COG2304	oxidoreductase activity
D1818_RS19090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1818_RS19095	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
D1818_RS19100	COG1231	oxidoreductase activity
D1818_RS19110	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS19115	COG1309	transcriptional regulator
D1818_RS19125	COG1215	transferase activity, transferring glycosyl groups
D1818_RS19135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1818_RS19240	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1818_RS19245	COG2169	Transcriptional regulator
D1818_RS19245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1818_RS19250	COG2819	hydrolase of the alpha beta superfamily
D1818_RS19260	COG0583	DNA-binding transcription factor activity
D1818_RS19265	COG5492	domain, Protein
D1818_RS19275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D1818_RS19280	COG0545	Peptidyl-prolyl cis-trans isomerase
D1818_RS19290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1818_RS19290	COG1199	ATP-dependent helicase activity
D1818_RS19300	COG2273	Hydrolase Family 16
D1818_RS19305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1818_RS19305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1818_RS19335	COG1090	epimerase
D1818_RS19375	COG0339	signal peptide processing
D1818_RS19380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1818_RS19385	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1818_RS19390	COG0563	adenylate kinase activity
D1818_RS19395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1818_RS19410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D1818_RS19425	COG1473	amidohydrolase
D1818_RS19430	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1818_RS19450	COG4771	TonB-dependent receptor
D1818_RS19465	COG0456	acetyltransferase
D1818_RS19550	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1818_RS19605	COG2259	Doxx family
D1818_RS19625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1818_RS19685	COG1629	transport
D1818_RS19735	COG0457	Tetratricopeptide repeat
D1818_RS19740	COG2373	Large extracellular alpha-helical protein
D1818_RS19745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1818_RS19765	COG2003	Belongs to the UPF0758 family
D1818_RS19795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1818_RS19805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1818_RS19825	COG1629	transport
D1818_RS19840	COG1629	transport
D1818_RS19850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D1818_RS19855	COG0049	tRNA binding
D1818_RS19860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1818_RS19865	COG0051	transcription antitermination factor activity, RNA binding
D1818_RS19870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1818_RS19875	COG0088	Forms part of the polypeptide exit tunnel
D1818_RS19880	COG0089	rRNA binding
D1818_RS19885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1818_RS19890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1818_RS19895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1818_RS19900	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1818_RS19905	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D1818_RS19910	COG0255	Belongs to the universal ribosomal protein uL29 family
D1818_RS19915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1818_RS19920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1818_RS19925	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1818_RS19930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1818_RS19935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1818_RS19940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1818_RS19945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1818_RS19950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D1818_RS19955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1818_RS19960	COG1841	ribosomal large subunit assembly
D1818_RS19965	COG0200	Binds to the 23S rRNA
D1818_RS19975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1818_RS19980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D1818_RS19985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1818_RS19990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1818_RS19995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1818_RS20000	COG0202	RNA polymerase activity
D1818_RS20005	COG0203	ribosomal protein L17
D1818_RS20010	COG0505	Belongs to the CarA family
D1818_RS20015	COG0148	phosphopyruvate hydratase activity
D1818_RS20035	COG1959	2 iron, 2 sulfur cluster binding
D1818_RS20045	COG0702	epimerase
D1818_RS20050	COG0018	arginyl-trna synthetase
D1818_RS20055	COG5002	protein histidine kinase activity
D1818_RS20085	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1818_RS20090	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1818_RS20095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1818_RS20100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D1818_RS20135	COG0101	tRNA pseudouridine synthase activity
D1818_RS20140	COG1132	(ABC) transporter
D1818_RS20155	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D1818_RS20160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D1818_RS20175	COG0601	transmembrane transport
D1818_RS20180	COG0149	triose-phosphate isomerase activity
D1818_RS20185	COG2264	protein methyltransferase activity
D1818_RS20215	COG1595	DNA-templated transcription, initiation
D1818_RS20275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1818_RS20305	COG0745	RESPONSE REGULATOR receiver
D1818_RS20305	COG2205	protein histidine kinase activity
D1818_RS20305	COG3292	Two component regulator propeller
D1818_RS20355	COG0668	transmembrane transport
D1818_RS20385	COG0783	Belongs to the Dps family
D1818_RS20420	COG0028	Belongs to the TPP enzyme family
D1818_RS20425	COG0668	transmembrane transport
D1818_RS20450	COG2116	formate transmembrane transporter activity
D1818_RS20470	COG0598	Magnesium transport protein CorA
D1818_RS20495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1818_RS20530	COG0174	glutamine synthetase
D1818_RS20570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1818_RS20575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1818_RS20585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1818_RS20590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D1818_RS20595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D1818_RS20600	COG0215	cysteine-tRNA ligase activity
D1818_RS20605	COG0302	gtp cyclohydrolase
D1818_RS20630	COG0442	prolyl-tRNA aminoacylation
D1818_RS20645	COG0268	Binds directly to 16S ribosomal RNA
D1818_RS20665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1818_RS20670	COG1663	tetraacyldisaccharide 4'-kinase activity
D1818_RS20680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1818_RS20685	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D1818_RS20705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1818_RS20710	COG0436	Aminotransferase
D1818_RS20725	COG0525	valine-tRNA ligase activity
D1818_RS20735	COG0688	phosphatidylethanolamine metabolic process
D1818_RS20740	COG4589	Belongs to the CDS family
D1818_RS20750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1818_RS20755	COG0799	negative regulation of ribosome biogenesis
D1818_RS20770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1818_RS20800	COG0659	secondary active sulfate transmembrane transporter activity
D1818_RS20845	COG0346	lactoylglutathione lyase activity
D1818_RS20855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D1818_RS20860	COG1181	Belongs to the D-alanine--D-alanine ligase family
D1818_RS20870	COG0564	pseudouridine synthase activity
D1818_RS20880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1818_RS20885	COG1278	Cold shock
D1818_RS20895	COG3022	response to hydroperoxide
D1818_RS20905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D1818_RS20915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1818_RS20920	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D1818_RS20950	COG1696	Membrane protein involved in D-alanine export
D1818_RS21010	COG1231	oxidoreductase activity
D1818_RS21020	COG3738	Protein conserved in bacteria
D1818_RS21040	COG4585	Histidine kinase
D1818_RS21065	COG0159	tryptophan synthase activity
D1818_RS21070	COG0133	tryptophan synthase activity
D1818_RS21075	COG0135	phosphoribosylanthranilate isomerase activity
D1818_RS21085	COG0134	indole-3-glycerol-phosphate synthase activity
D1818_RS21090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1818_RS21095	COG0512	Glutamine amidotransferase of anthranilate synthase
D1818_RS21100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1818_RS21115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1818_RS21125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1818_RS21145	COG0739	heme binding
D1818_RS21150	COG2197	response regulator
D1818_RS21175	COG0284	orotidine-5'-phosphate decarboxylase activity
D1818_RS21180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1818_RS21200	COG4771	TonB-dependent receptor
D1818_RS21210	COG0788	formyltetrahydrofolate deformylase activity
D1818_RS21220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1818_RS21220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1818_RS21220	COG1703	isobutyryl-CoA mutase activity
D1818_RS21225	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1818_RS21240	COG1522	sequence-specific DNA binding
D1818_RS21250	COG1115	amino acid carrier protein
D1818_RS21255	COG0668	transmembrane transport
D1818_RS21290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D1818_RS21305	COG2205	protein histidine kinase activity
D1818_RS21310	COG2197	response regulator
D1818_RS21340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1818_RS21350	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D1818_RS21350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1818_RS21355	COG1090	epimerase
D1818_RS21365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1818_RS21370	COG0484	heat shock protein binding
D1818_RS21375	COG4152	abc transporter atp-binding protein
D1818_RS21380	COG1668	transmembrane transport
D1818_RS21385	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1818_RS21385	COG3264	Mechanosensitive ion channel
D1818_RS21405	COG2326	polyphosphate kinase activity
D1818_RS21420	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D1818_RS21450	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D1818_RS21465	COG0534	Mate efflux family protein
D1818_RS21480	COG0671	phosphoesterase, PA-phosphatase related
D1818_RS21495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1818_RS21510	COG1703	isobutyryl-CoA mutase activity
D1818_RS21520	COG1233	COG1233 Phytoene dehydrogenase and related
D1818_RS21560	COG1595	DNA-templated transcription, initiation
D1818_RS21585	COG1695	Transcriptional regulator
D1818_RS21595	COG0653	protein targeting
D1818_RS21605	COG2096	Adenosyltransferase
D1818_RS21610	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1818_RS21620	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1818_RS21695	COG1131	(ABC) transporter
D1818_RS21735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1818_RS21740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1818_RS21745	COG1121	(ABC) transporter
D1818_RS21750	COG0803	Belongs to the bacterial solute-binding protein 9 family
D1818_RS21770	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1818_RS21780	COG1058	Belongs to the CinA family
D1818_RS21780	COG1546	Belongs to the CinA family
D1818_RS21810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1818_RS21815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D1818_RS21825	COG0552	protein localization to endoplasmic reticulum
D1818_RS21840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1818_RS21845	COG0778	Nitroreductase
D1818_RS21850	COG1741	Belongs to the pirin family
D1818_RS21860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1818_RS21860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1818_RS21865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1818_RS21880	COG0339	signal peptide processing
D1818_RS21895	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D1818_RS21955	COG0519	Catalyzes the synthesis of GMP from XMP
D1818_RS21955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1818_RS21970	COG3530	Putative quorum-sensing-regulated virulence factor
D1818_RS21975	COG1228	amidohydrolase
D1818_RS21980	COG0019	diaminopimelate decarboxylase activity
D1818_RS21990	COG0045	succinate-CoA ligase (ADP-forming) activity
D1818_RS22000	COG1528	Iron-storage protein
D1818_RS22075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1818_RS22085	COG1063	alcohol dehydrogenase
D1818_RS22100	COG1902	pentaerythritol trinitrate reductase activity
D1818_RS22135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D1818_RS22140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1818_RS22155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D1818_RS22165	COG3608	succinylglutamate desuccinylase aspartoacylase
D1818_RS22165	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D1818_RS22170	COG0590	tRNA wobble adenosine to inosine editing
D1818_RS22185	COG1278	Cold shock
D1818_RS22190	COG0596	Alpha beta hydrolase
D1818_RS22245	COG0671	phosphoesterase, PA-phosphatase related
D1818_RS22250	COG0517	IMP dehydrogenase activity
D1818_RS22250	COG0516	GMP reductase activity
D1818_RS22275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1818_RS22285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1818_RS22290	COG0714	Associated with various cellular activities
D1818_RS22310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1818_RS22320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1818_RS22355	COG1611	Belongs to the LOG family
D1818_RS22360	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D1818_RS22365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1818_RS22390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1818_RS22405	COG1233	COG1233 Phytoene dehydrogenase and related
D1818_RS22435	COG1595	DNA-templated transcription, initiation
D1818_RS22445	COG1629	transport
D1818_RS22445	COG4206	TonB-dependent receptor
D1818_RS22450	COG0739	heme binding
D1818_RS22470	COG5002	protein histidine kinase activity
D1818_RS22470	COG5001	Diguanylate cyclase
D1818_RS22470	COG3447	MASE1 domain protein
D1818_RS22490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D1818_RS22495	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D1818_RS22505	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1818_RS22520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D1818_RS22525	COG3959	Transketolase, thiamine diphosphate binding domain
D1818_RS22530	COG0343	queuine tRNA-ribosyltransferase activity
D1818_RS22545	COG0825	malonyl-CoA metabolic process
D1818_RS22550	COG0305	Participates in initiation and elongation during chromosome replication
D1818_RS22565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1818_RS22575	COG0402	S-adenosylhomocysteine deaminase activity
D1818_RS22580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1818_RS22590	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1818_RS22595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1818_RS22605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1818_RS22610	COG0105	UTP biosynthetic process
D1818_RS22630	COG1595	DNA-templated transcription, initiation
D1818_RS22650	COG1607	acyl-coa hydrolase
D1818_RS22665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1818_RS22675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1818_RS22685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D1818_RS22720	COG0681	Belongs to the peptidase S26 family
D1818_RS22725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D1818_RS22735	COG1475	DNA binding
D1818_RS22740	COG1192	Involved in chromosome partitioning
D1818_RS22745	COG0612	Peptidase, M16
D1818_RS22750	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS22755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1818_RS22755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1818_RS22770	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1818_RS22770	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1818_RS22780	COG0572	uridine kinase
D1818_RS22800	COG2133	pyrroloquinoline quinone binding
D1818_RS22825	COG3250	beta-galactosidase activity
D1818_RS22835	COG5492	domain, Protein
D1818_RS22860	COG0037	tRNA processing
D1818_RS22890	COG5002	protein histidine kinase activity
D1818_RS22930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1818_RS22945	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D1818_RS22950	COG4206	TonB-dependent receptor
D1818_RS22950	COG1629	transport
D1818_RS22965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1818_RS22970	COG1554	hydrolase, family 65, central catalytic
D1818_RS22975	COG0366	Alpha amylase catalytic
D1818_RS22980	COG0366	Alpha amylase catalytic
D1818_RS22990	COG0205	6-phosphofructokinase activity
D1818_RS23010	COG4585	Histidine kinase
D1818_RS23025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1818_RS23045	COG2223	nitrite transmembrane transporter activity
D1818_RS23050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1818_RS23055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1818_RS23060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1818_RS23060	COG1116	anion transmembrane transporter activity
D1818_RS23065	COG1116	anion transmembrane transporter activity
D1818_RS23080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1818_RS23080	COG1333	cytochrome c biogenesis protein
D1818_RS23085	COG1333	cytochrome c biogenesis protein
D1818_RS23085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1818_RS23120	COG0243	molybdopterin cofactor binding
D1818_RS23150	COG0784	Response regulator, receiver
D1818_RS23150	COG2198	Histidine kinase
D1818_RS23150	COG5002	protein histidine kinase activity
D1818_RS23160	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1818_RS23160	COG0315	cyclic pyranopterin monophosphate synthase activity
D1818_RS23165	COG0314	molybdopterin synthase activity
D1818_RS23175	COG0746	molybdenum cofactor guanylyltransferase activity
D1818_RS23185	COG0303	'Molybdopterin
D1818_RS23210	COG3590	peptidase
D1818_RS23220	COG0527	aspartate kinase activity
D1818_RS23225	COG0606	chelatase, subunit chli
D1818_RS23350	COG1914	H( )-stimulated, divalent metal cation uptake system
D1818_RS23360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1818_RS23385	COG2197	response regulator
D1818_RS23390	COG0129	dihydroxy-acid dehydratase activity
D1818_RS23395	COG0028	Belongs to the TPP enzyme family
D1818_RS23405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1818_RS23415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D1818_RS23425	COG1607	acyl-coa hydrolase
D1818_RS23460	COG1120	ATPase activity
D1818_RS23465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1818_RS23485	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1818_RS23495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1818_RS23500	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
D1818_RS23505	COG4206	TonB-dependent receptor
D1818_RS23545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1818_RS23575	COG2885	chlorophyll binding
D1818_RS23615	COG0300	oxidoreductase activity
D1818_RS23620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D1818_RS23630	COG0488	(ABC) transporter
D1818_RS23690	COG0280	phosphate acetyltransferase
D1818_RS23690	COG0857	belongs to the CobB CobQ family
D1818_RS23695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D1818_RS23725	COG0592	DNA-directed DNA polymerase activity
D1818_RS23740	COG3250	beta-galactosidase activity
D1818_RS23780	COG1702	phosphate starvation-inducible protein PhoH
D1818_RS23785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1818_RS23825	COG0473	3-isopropylmalate dehydrogenase activity
D1818_RS23830	COG0066	3-isopropylmalate dehydratase activity
D1818_RS23835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1818_RS23840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1818_RS23860	COG0564	pseudouridine synthase activity
D1818_RS23865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D1818_RS23880	COG1760	l-serine dehydratase
D1818_RS23885	COG0443	Heat shock 70 kDa protein
D1818_RS23900	COG0405	Gamma-glutamyltransferase
D1818_RS23915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1818_RS23920	COG1560	Kdo2-lipid A biosynthetic process
D1818_RS23935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1818_RS23960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1818_RS23970	COG0783	Belongs to the Dps family
D1818_RS23975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D1818_RS23995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1818_RS24005	COG5002	protein histidine kinase activity
D1818_RS24010	COG0745	RESPONSE REGULATOR receiver
D1818_RS24015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1818_RS24030	COG1363	Peptidase, m42
D1818_RS24065	COG5002	protein histidine kinase activity
D1818_RS24065	COG2198	Histidine kinase
D1818_RS24065	COG0784	Response regulator, receiver
D1818_RS24070	COG1272	protein, Hemolysin III
D1818_RS24090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1818_RS24095	COG0116	Belongs to the methyltransferase superfamily
D1818_RS24110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1818_RS24115	COG1595	DNA-templated transcription, initiation
D1818_RS24125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1818_RS24180	COG1104	cysteine desulfurase activity
D1818_RS24190	COG0739	heme binding
D1818_RS24210	COG1418	mRNA catabolic process
D1818_RS24230	COG0542	response to heat
D1818_RS24235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1818_RS24295	COG2205	protein histidine kinase activity
D1818_RS24325	COG3209	COG3209 Rhs family protein
D1818_RS24325	COG4104	PAAR repeat-containing protein
D1818_RS24435	COG0791	NLP P60 protein
D1818_RS24470	COG0302	gtp cyclohydrolase
D1818_RS24490	COG0415	Belongs to the DNA photolyase family
D1818_RS24495	COG3046	protein related to deoxyribodipyrimidine photolyase
D1818_RS24500	COG0415	Belongs to the DNA photolyase family
D1818_RS24530	COG2234	aminopeptidase activity
D1818_RS24540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D1818_RS24545	COG0626	cystathionine gamma-synthase activity
D1818_RS24555	COG0450	alkyl hydroperoxide reductase
D1818_RS24560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1818_RS24570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D1818_RS24580	COG1674	ftsk spoiiie
D1818_RS24595	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1818_RS24595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1818_RS24600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D1818_RS24610	COG0778	Nitroreductase
D1818_RS24615	COG1607	acyl-coa hydrolase
D1818_RS24620	COG1757	Na H antiporter
D1818_RS24630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1818_RS24635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D1818_RS24645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1818_RS24645	COG1333	cytochrome c biogenesis protein
D1818_RS24650	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1818_RS24660	COG4771	TonB-dependent receptor
D1818_RS24665	COG0702	epimerase
D1818_RS24735	COG2986	histidine ammonia-lyase
D1818_RS24745	COG1028	Short-chain dehydrogenase reductase Sdr
D1818_RS24750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1818_RS24755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1818_RS24770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1818_RS24790	COG1131	(ABC) transporter
D1818_RS24815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D1818_RS24830	COG0726	polysaccharide deacetylase
D1818_RS24845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D1818_RS24885	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D1818_RS24935	COG0628	permease
D1818_RS25000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1818_RS25010	COG0205	6-phosphofructokinase activity
D1818_RS25025	COG0251	oxidation-reduction process
D1818_RS25035	COG0860	N-Acetylmuramoyl-L-alanine amidase
D1818_RS25045	COG0247	lactate metabolic process
D1818_RS25045	COG2181	nitrate reductase activity
D1818_RS25055	COG2181	nitrate reductase activity
D1818_RS25055	COG0247	lactate metabolic process
D1818_RS25065	COG1472	Belongs to the glycosyl hydrolase 3 family
D1818_RS25070	COG4989	oxidoreductase activity
D1818_RS25095	COG1459	type II secretion system