locus-tag	class	description
HN014_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HN014_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HN014_RS00025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HN014_RS00035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HN014_RS00040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN014_RS00055	COG0336	Belongs to the RNA methyltransferase TrmD family
HN014_RS00060	COG0335	large ribosomal subunit rRNA binding
HN014_RS00070	COG1595	DNA-templated transcription, initiation
HN014_RS00110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HN014_RS00130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HN014_RS00135	COG0587	DNA-directed DNA polymerase activity
HN014_RS00140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HN014_RS00200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HN014_RS00205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HN014_RS00210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HN014_RS00215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HN014_RS00225	COG0784	Response regulator, receiver
HN014_RS00225	COG2205	protein histidine kinase activity
HN014_RS00230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN014_RS00245	COG0735	belongs to the Fur family
HN014_RS00250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HN014_RS00270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN014_RS00290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HN014_RS00310	COG1629	transport
HN014_RS00310	COG4206	TonB-dependent receptor
HN014_RS00315	COG4753	response regulator
HN014_RS00315	COG2207	Transcriptional regulator
HN014_RS00320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HN014_RS00340	COG3956	TIGRFAM MazG family protein
HN014_RS00350	COG0482	sulfurtransferase activity
HN014_RS00360	COG0706	membrane insertase activity
HN014_RS00365	COG0504	CTP synthase activity
HN014_RS00375	COG0242	peptide deformylase activity
HN014_RS00380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HN014_RS00395	COG0463	Glycosyl transferase, family 2
HN014_RS00420	COG0617	tRNA 3'-terminal CCA addition
HN014_RS00425	COG1612	heme a metabolic process
HN014_RS00450	COG1131	(ABC) transporter
HN014_RS00465	COG0556	nucleotide-excision repair
HN014_RS00500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HN014_RS00510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS00525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HN014_RS00530	COG0512	Glutamine amidotransferase of anthranilate synthase
HN014_RS00535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HN014_RS00540	COG0134	indole-3-glycerol-phosphate synthase activity
HN014_RS00545	COG0135	phosphoribosylanthranilate isomerase activity
HN014_RS00550	COG0133	tryptophan synthase activity
HN014_RS00555	COG0159	tryptophan synthase activity
HN014_RS00595	COG1696	Membrane protein involved in D-alanine export
HN014_RS00610	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HN014_RS00655	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HN014_RS00665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HN014_RS00670	COG3022	response to hydroperoxide
HN014_RS00675	COG0778	Nitroreductase
HN014_RS00675	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HN014_RS00685	COG0564	pseudouridine synthase activity
HN014_RS00690	COG2815	serine threonine protein kinase
HN014_RS00690	COG0515	serine threonine protein kinase
HN014_RS00695	COG1181	Belongs to the D-alanine--D-alanine ligase family
HN014_RS00700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HN014_RS00720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HN014_RS00730	COG0659	secondary active sulfate transmembrane transporter activity
HN014_RS00740	COG0494	nUDIX hydrolase
HN014_RS00745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HN014_RS00760	COG0799	negative regulation of ribosome biogenesis
HN014_RS00765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HN014_RS00775	COG4589	Belongs to the CDS family
HN014_RS00780	COG0688	phosphatidylethanolamine metabolic process
HN014_RS00790	COG0525	valine-tRNA ligase activity
HN014_RS00805	COG0436	Aminotransferase
HN014_RS00810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HN014_RS00825	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HN014_RS00830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HN014_RS00835	COG4999	Histidine kinase
HN014_RS00835	COG2205	protein histidine kinase activity
HN014_RS00835	COG3437	response regulator, receiver
HN014_RS00835	COG3850	Histidine kinase
HN014_RS00840	COG1663	tetraacyldisaccharide 4'-kinase activity
HN014_RS00845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HN014_RS00860	COG1846	Transcriptional regulator
HN014_RS00880	COG0268	Binds directly to 16S ribosomal RNA
HN014_RS00895	COG0442	prolyl-tRNA aminoacylation
HN014_RS00915	COG0302	gtp cyclohydrolase
HN014_RS00920	COG0215	cysteine-tRNA ligase activity
HN014_RS00925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HN014_RS00930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HN014_RS00935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HN014_RS00995	COG4796	Type ii and iii secretion system protein
HN014_RS01000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HN014_RS01010	COG4968	Prepilin-type N-terminal cleavage methylation domain
HN014_RS01065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HN014_RS01075	COG1462	curli production assembly transport component CsgG
HN014_RS01115	COG3275	phosphorelay sensor kinase activity
HN014_RS01120	COG3279	Response regulator of the LytR AlgR family
HN014_RS01130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HN014_RS01190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN014_RS01240	COG1131	(ABC) transporter
HN014_RS01250	COG0215	cysteine-tRNA ligase activity
HN014_RS01255	COG4771	TonB-dependent receptor
HN014_RS01265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN014_RS01265	COG5549	protein import
HN014_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_RS01305	COG4771	TonB-dependent receptor
HN014_RS01365	COG3275	phosphorelay sensor kinase activity
HN014_RS01370	COG3279	Response regulator of the LytR AlgR family
HN014_RS01410	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HN014_RS01445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS01450	COG3275	phosphorelay sensor kinase activity
HN014_RS01465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS01480	COG2226	methyltransferase
HN014_RS01525	COG0604	alcohol dehydrogenase
HN014_RS01525	COG3321	synthase
HN014_RS01530	COG3321	synthase
HN014_RS01530	COG0604	alcohol dehydrogenase
HN014_RS01570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN014_RS01620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HN014_RS01645	COG1335	isochorismatase
HN014_RS01650	COG2095	MarC family integral membrane protein
HN014_RS01660	COG0753	catalase activity
HN014_RS01680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HN014_RS01690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HN014_RS01700	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HN014_RS01715	COG0076	glutamate decarboxylase activity
HN014_RS01720	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HN014_RS01750	COG4771	TonB-dependent receptor
HN014_RS01770	COG2264	protein methyltransferase activity
HN014_RS01775	COG0149	triose-phosphate isomerase activity
HN014_RS01795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HN014_RS01820	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HN014_RS01825	COG3279	Response regulator of the LytR AlgR family
HN014_RS01830	COG2972	Histidine kinase
HN014_RS01835	COG4771	TonB-dependent receptor
HN014_RS01840	COG1132	(ABC) transporter
HN014_RS01875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HN014_RS01880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HN014_RS01885	COG0018	arginyl-trna synthetase
HN014_RS01890	COG1959	2 iron, 2 sulfur cluster binding
HN014_RS01900	COG0010	Belongs to the arginase family
HN014_RS01910	COG0148	phosphopyruvate hydratase activity
HN014_RS01915	COG0505	Belongs to the CarA family
HN014_RS01920	COG0203	ribosomal protein L17
HN014_RS01925	COG0202	RNA polymerase activity
HN014_RS01930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HN014_RS01935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HN014_RS01940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HN014_RS01945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HN014_RS01950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HN014_RS01960	COG0200	Binds to the 23S rRNA
HN014_RS01965	COG1841	ribosomal large subunit assembly
HN014_RS01970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HN014_RS01975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HN014_RS01980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HN014_RS01985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HN014_RS01990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HN014_RS01995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HN014_RS02000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HN014_RS02005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HN014_RS02010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HN014_RS02015	COG0255	Belongs to the universal ribosomal protein uL29 family
HN014_RS02020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HN014_RS02025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HN014_RS02030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HN014_RS02035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HN014_RS02040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HN014_RS02045	COG0089	rRNA binding
HN014_RS02050	COG0088	Forms part of the polypeptide exit tunnel
HN014_RS02055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HN014_RS02060	COG0051	transcription antitermination factor activity, RNA binding
HN014_RS02065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HN014_RS02070	COG0049	tRNA binding
HN014_RS02075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HN014_RS02080	COG4771	TonB-dependent receptor
HN014_RS02095	COG4206	TonB-dependent receptor
HN014_RS02095	COG1629	transport
HN014_RS02105	COG4771	TonB-dependent receptor
HN014_RS02115	COG1629	transport
HN014_RS02115	COG4206	TonB-dependent receptor
HN014_RS02125	COG4771	TonB-dependent receptor
HN014_RS02130	COG0702	epimerase
HN014_RS02135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN014_RS02145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HN014_RS02175	COG2003	Belongs to the UPF0758 family
HN014_RS02190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HN014_RS02195	COG2373	Large extracellular alpha-helical protein
HN014_RS02205	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_RS02210	COG2207	Transcriptional regulator
HN014_RS02220	COG1045	serine acetyltransferase
HN014_RS02230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HN014_RS02235	COG0563	adenylate kinase activity
HN014_RS02240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HN014_RS02245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HN014_RS02290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HN014_RS02290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HN014_RS02320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HN014_RS02325	COG1127	ABC transporter
HN014_RS02370	COG2234	aminopeptidase activity
HN014_RS02375	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_RS02380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HN014_RS02390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN014_RS02395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HN014_RS02405	COG3537	Alpha-1,2-mannosidase
HN014_RS02410	COG0702	epimerase
HN014_RS02415	COG1629	transport
HN014_RS02460	COG0848	biopolymer transport protein
HN014_RS02465	COG0811	peptide transport
HN014_RS02470	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HN014_RS02480	COG1960	acyl-CoA dehydrogenase activity
HN014_RS02545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HN014_RS02575	COG0321	lipoyl(octanoyl) transferase activity
HN014_RS02590	COG2197	response regulator
HN014_RS02605	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HN014_RS02610	COG0523	cobalamin synthesis protein
HN014_RS02635	COG4682	membrane
HN014_RS02650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HN014_RS02655	COG1705	Flagellar rod assembly protein muramidase FlgJ
HN014_RS02655	COG1388	LysM domain
HN014_RS02715	COG1595	DNA-templated transcription, initiation
HN014_RS02760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HN014_RS02810	COG0793	Belongs to the peptidase S41A family
HN014_RS02840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HN014_RS02845	COG1690	Belongs to the RtcB family
HN014_RS02855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_RS02900	COG0629	single-stranded DNA binding
HN014_RS02915	COG2249	NAD(P)H dehydrogenase (quinone) activity
HN014_RS02930	COG0546	phosphoglycolate phosphatase activity
HN014_RS02935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HN014_RS02945	COG0489	protein tyrosine kinase activity
HN014_RS02950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN014_RS02960	COG1696	Membrane protein involved in D-alanine export
HN014_RS03000	COG0438	transferase activity, transferring glycosyl groups
HN014_RS03040	COG0546	phosphoglycolate phosphatase activity
HN014_RS03045	COG0022	dehydrogenase e1 component
HN014_RS03050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HN014_RS03055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_RS03075	COG2030	dehydratase
HN014_RS03075	COG1012	belongs to the aldehyde dehydrogenase family
HN014_RS03080	COG0183	Belongs to the thiolase family
HN014_RS03095	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_RS03100	COG1024	Enoyl-CoA hydratase
HN014_RS03105	COG2151	metal-sulfur cluster biosynthetic enzyme
HN014_RS03110	COG3396	Phenylacetate-CoA oxygenase
HN014_RS03115	COG3460	Phenylacetate-CoA oxygenase
HN014_RS03120	COG3396	Phenylacetate-CoA oxygenase
HN014_RS03125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HN014_RS03140	COG3186	Phenylalanine-4-hydroxylase
HN014_RS03155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HN014_RS03190	COG1160	GTP binding
HN014_RS03200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HN014_RS03205	COG0784	Response regulator, receiver
HN014_RS03215	COG4251	negative regulation of phosphorylation
HN014_RS03225	COG2205	protein histidine kinase activity
HN014_RS03235	COG3279	Response regulator of the LytR AlgR family
HN014_RS03280	COG0463	Glycosyl transferase, family 2
HN014_RS03285	COG1115	amino acid carrier protein
HN014_RS03355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN014_RS03365	COG2885	chlorophyll binding
HN014_RS03395	COG1629	transport
HN014_RS03395	COG4206	TonB-dependent receptor
HN014_RS03430	COG1858	cytochrome C peroxidase
HN014_RS03440	COG4771	TonB-dependent receptor
HN014_RS03465	COG3279	Response regulator of the LytR AlgR family
HN014_RS03470	COG2972	Histidine kinase
HN014_RS03480	COG2378	regulation of single-species biofilm formation
HN014_RS03490	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HN014_RS03505	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HN014_RS03510	COG4263	nitrous-oxide reductase activity
HN014_RS03535	COG1131	(ABC) transporter
HN014_RS03570	COG0315	cyclic pyranopterin monophosphate synthase activity
HN014_RS03585	COG0746	molybdenum cofactor guanylyltransferase activity
HN014_RS03595	COG2005	Transcriptional regulator
HN014_RS03600	COG0303	'Molybdopterin
HN014_RS03605	COG3005	denitrification pathway
HN014_RS03610	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HN014_RS03620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HN014_RS03645	COG0437	4 iron, 4 sulfur cluster binding
HN014_RS03670	COG4585	Histidine kinase
HN014_RS03675	COG4585	Histidine kinase
HN014_RS03895	COG3279	Response regulator of the LytR AlgR family
HN014_RS03900	COG2972	Histidine kinase
HN014_RS03900	COG0745	RESPONSE REGULATOR receiver
HN014_RS03955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HN014_RS03965	COG4968	Prepilin-type N-terminal cleavage methylation domain
HN014_RS04010	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HN014_RS04020	COG3586	endonuclease activity
HN014_RS04380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN014_RS04475	COG1846	Transcriptional regulator
HN014_RS04620	COG0823	Involved in the tonB-independent uptake of proteins
HN014_RS04640	COG0488	(ABC) transporter
HN014_RS04670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN014_RS04680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HN014_RS04680	COG1754	DNA topoisomerase type I activity
HN014_RS04690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN014_RS04715	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HN014_RS04720	COG0459	protein refolding
HN014_RS04745	COG2217	Heavy metal translocating P-type atpase
HN014_RS04760	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN014_RS04775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HN014_RS04790	COG1253	flavin adenine dinucleotide binding
HN014_RS04815	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HN014_RS04830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN014_RS04835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN014_RS04840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HN014_RS04845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN014_RS04855	COG1629	transport
HN014_RS04875	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HN014_RS04900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HN014_RS04925	COG0662	Cupin 2, conserved barrel domain protein
HN014_RS04990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HN014_RS05010	COG1215	transferase activity, transferring glycosyl groups
HN014_RS05020	COG1187	pseudouridine synthase activity
HN014_RS05055	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HN014_RS05060	COG1309	transcriptional regulator
HN014_RS05075	COG2081	HI0933 family
HN014_RS05080	COG0584	glycerophosphoryl diester phosphodiesterase
HN014_RS05095	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HN014_RS05100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HN014_RS05105	COG0228	four-way junction DNA binding
HN014_RS05150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HN014_RS05155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HN014_RS05175	COG2315	Protein conserved in bacteria
HN014_RS05180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HN014_RS05195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN014_RS05210	COG3938	Belongs to the proline racemase family
HN014_RS05215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN014_RS05220	COG0006	proline dipeptidase activity
HN014_RS05265	COG1999	signal sequence binding
HN014_RS05285	COG3279	Response regulator of the LytR AlgR family
HN014_RS05290	COG3275	phosphorelay sensor kinase activity
HN014_RS05295	COG4771	TonB-dependent receptor
HN014_RS05305	COG0363	glucosamine-6-phosphate deaminase activity
HN014_RS05310	COG1609	Transcriptional regulator
HN014_RS05315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HN014_RS05330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HN014_RS05345	COG0745	RESPONSE REGULATOR receiver
HN014_RS05365	COG1595	DNA-templated transcription, initiation
HN014_RS05375	COG4206	TonB-dependent receptor
HN014_RS05375	COG1629	transport
HN014_RS05410	COG4771	TonB-dependent receptor
HN014_RS05440	COG0513	Belongs to the DEAD box helicase family
HN014_RS05455	COG4206	TonB-dependent receptor
HN014_RS05455	COG1629	transport
HN014_RS05480	COG0589	response to stress
HN014_RS05490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HN014_RS05490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN014_RS05500	COG2217	Heavy metal translocating P-type atpase
HN014_RS05505	COG0259	pyridoxamine-phosphate oxidase activity
HN014_RS05515	COG3278	Belongs to the heme-copper respiratory oxidase family
HN014_RS05530	COG0348	domain, Protein
HN014_RS05555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HN014_RS05560	COG0589	response to stress
HN014_RS05565	COG0745	RESPONSE REGULATOR receiver
HN014_RS05570	COG5002	protein histidine kinase activity
HN014_RS05605	COG0489	protein tyrosine kinase activity
HN014_RS05620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HN014_RS05625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HN014_RS05630	COG5002	protein histidine kinase activity
HN014_RS05635	COG0745	RESPONSE REGULATOR receiver
HN014_RS05655	COG1629	transport
HN014_RS05665	COG0534	Mate efflux family protein
HN014_RS05695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HN014_RS05700	COG0702	epimerase
HN014_RS05710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN014_RS05715	COG0463	Glycosyl transferase, family 2
HN014_RS05730	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HN014_RS05735	COG2363	Small membrane protein
HN014_RS05745	COG1522	sequence-specific DNA binding
HN014_RS05765	COG0495	leucyl-tRNA aminoacylation
HN014_RS05770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HN014_RS05775	COG2177	Part of the ABC transporter FtsEX involved in
HN014_RS05780	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HN014_RS05795	COG1968	undecaprenyl-diphosphatase activity
HN014_RS05800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HN014_RS05820	COG0519	Catalyzes the synthesis of GMP from XMP
HN014_RS05825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HN014_RS05830	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HN014_RS05840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HN014_RS05845	COG3852	Histidine kinase
HN014_RS05865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HN014_RS05875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HN014_RS05880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HN014_RS05885	COG2022	thiamine diphosphate biosynthetic process
HN014_RS05890	COG0352	thiamine-phosphate diphosphorylase activity
HN014_RS05895	COG0351	phosphomethylpyrimidine kinase
HN014_RS05905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HN014_RS05920	COG2205	protein histidine kinase activity
HN014_RS05920	COG5002	protein histidine kinase activity
HN014_RS05920	COG0784	Response regulator, receiver
HN014_RS05925	COG2204	response regulator
HN014_RS05960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HN014_RS05970	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HN014_RS05975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HN014_RS05985	COG0612	Peptidase, M16
HN014_RS06015	COG1194	a g-specific adenine glycosylase
HN014_RS06020	COG0776	regulation of translation
HN014_RS06025	COG1530	ribonuclease E activity
HN014_RS06100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HN014_RS06105	COG0596	Alpha beta hydrolase
HN014_RS06110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HN014_RS06120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HN014_RS06125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HN014_RS06145	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HN014_RS06165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HN014_RS06170	COG0463	Glycosyl transferase, family 2
HN014_RS06180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HN014_RS06190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HN014_RS06200	COG0297	glycogen (starch) synthase activity
HN014_RS06205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HN014_RS06210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HN014_RS06225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HN014_RS06235	COG0667	Aldo Keto reductase
HN014_RS06250	COG4771	TonB-dependent receptor
HN014_RS06265	COG1360	Flagellar Motor Protein
HN014_RS06270	COG0708	Exodeoxyribonuclease III
HN014_RS06275	COG1137	ATPase activity
HN014_RS06295	COG0423	glycine-tRNA ligase activity
HN014_RS06305	COG1040	competence protein
HN014_RS06315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HN014_RS06320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HN014_RS06335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HN014_RS06340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HN014_RS06350	COG0189	ligase activity
HN014_RS06355	COG4067	protein conserved in archaea
HN014_RS06355	COG0189	ligase activity
HN014_RS06360	COG0322	excinuclease ABC activity
HN014_RS06365	COG1752	Esterase of the alpha-beta hydrolase superfamily
HN014_RS06370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HN014_RS06375	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HN014_RS06395	COG0166	Belongs to the GPI family
HN014_RS06420	COG0481	GTPase activity
HN014_RS06435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HN014_RS06440	COG0346	lactoylglutathione lyase activity
HN014_RS06490	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HN014_RS06500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HN014_RS06505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_RS06510	COG0511	ligase activity, forming carbon-carbon bonds
HN014_RS06515	COG0439	Biotin carboxylase
HN014_RS06540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HN014_RS06560	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HN014_RS06560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HN014_RS06585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HN014_RS06600	COG1435	thymidine kinase activity
HN014_RS06605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HN014_RS06610	COG1970	mechanosensitive ion channel activity
HN014_RS06615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HN014_RS06625	COG1505	serine-type exopeptidase activity
HN014_RS06630	COG3842	ATPase activity
HN014_RS06640	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN014_RS06650	COG0720	synthase
HN014_RS06655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HN014_RS06660	COG0534	Mate efflux family protein
HN014_RS06700	COG0210	DNA helicase
HN014_RS06735	COG0328	RNA-DNA hybrid ribonuclease activity
HN014_RS06735	COG3341	Caulimovirus viroplasmin
HN014_RS06745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN014_RS06750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HN014_RS06755	COG0571	ribonuclease III activity
HN014_RS06765	COG0469	pyruvate kinase activity
HN014_RS06780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HN014_RS06810	COG3279	Response regulator of the LytR AlgR family
HN014_RS06820	COG4447	cellulose binding
HN014_RS06825	COG0006	proline dipeptidase activity
HN014_RS06840	COG1114	Component of the transport system for branched-chain amino acids
HN014_RS06855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HN014_RS06880	COG1858	cytochrome C peroxidase
HN014_RS06885	COG0316	Belongs to the HesB IscA family
HN014_RS06890	COG0719	Fe-S assembly protein
HN014_RS06900	COG0396	ATPase activity
HN014_RS06905	COG0719	Fe-S assembly protein
HN014_RS06910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HN014_RS06930	COG2166	iron-sulfur cluster assembly
HN014_RS06935	COG2151	metal-sulfur cluster biosynthetic enzyme
HN014_RS06960	COG0454	-acetyltransferase
HN014_RS06970	COG0519	Catalyzes the synthesis of GMP from XMP
HN014_RS06975	COG1073	alpha beta
HN014_RS06980	COG0583	DNA-binding transcription factor activity
HN014_RS07000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN014_RS07015	COG0594	ribonuclease P activity
HN014_RS07020	COG0793	Belongs to the peptidase S41A family
HN014_RS07030	COG0698	ribose 5-phosphate isomerase
HN014_RS07045	COG0557	exoribonuclease II activity
HN014_RS07065	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HN014_RS07070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN014_RS07080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN014_RS07085	COG3239	Fatty acid desaturase
HN014_RS07095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HN014_RS07100	COG0445	tRNA wobble uridine modification
HN014_RS07140	COG0657	acetylesterase activity
HN014_RS07155	COG0126	phosphoglycerate kinase activity
HN014_RS07160	COG0741	lytic transglycosylase activity
HN014_RS07160	COG1388	LysM domain
HN014_RS07175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HN014_RS07180	COG0739	heme binding
HN014_RS07200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HN014_RS07205	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HN014_RS07215	COG1091	dTDP-4-dehydrorhamnose reductase activity
HN014_RS07220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HN014_RS07250	COG1215	transferase activity, transferring glycosyl groups
HN014_RS07255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN014_RS07260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HN014_RS07265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN014_RS07275	COG0151	Belongs to the GarS family
HN014_RS07295	COG0859	PFAM glycosyl transferase family 9
HN014_RS07335	COG0356	it plays a direct role in the translocation of protons across the membrane
HN014_RS07340	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN014_RS07345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HN014_RS07350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN014_RS07355	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HN014_RS07360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HN014_RS07385	COG0756	dUTP diphosphatase activity
HN014_RS07415	COG0640	Transcriptional regulator
HN014_RS07420	COG1607	acyl-coa hydrolase
HN014_RS07440	COG1472	Belongs to the glycosyl hydrolase 3 family
HN014_RS07445	COG2897	thiosulfate sulfurtransferase activity
HN014_RS07455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HN014_RS07465	COG0662	Cupin 2, conserved barrel domain protein
HN014_RS07475	COG1012	belongs to the aldehyde dehydrogenase family
HN014_RS07505	COG4260	virion core protein, lumpy skin disease virus
HN014_RS07515	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HN014_RS07525	COG0754	glutathionylspermidine amidase activity
HN014_RS07530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HN014_RS07545	COG4221	oxidoreductase activity
HN014_RS07550	COG0714	Associated with various cellular activities
HN014_RS07565	COG2304	oxidoreductase activity
HN014_RS07570	COG2304	oxidoreductase activity
HN014_RS07600	COG0288	reversible hydration of carbon dioxide
HN014_RS07605	COG0659	secondary active sulfate transmembrane transporter activity
HN014_RS07635	COG1595	DNA-templated transcription, initiation
HN014_RS07660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HN014_RS07685	COG2201	protein-glutamate methylesterase activity
HN014_RS07710	COG1595	DNA-templated transcription, initiation
HN014_RS07720	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HN014_RS07730	COG1774	PSP1 C-terminal conserved region
HN014_RS07740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HN014_RS07745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HN014_RS07750	COG0450	alkyl hydroperoxide reductase
HN014_RS07760	COG4172	Belongs to the ABC transporter superfamily
HN014_RS07770	COG1024	Enoyl-CoA hydratase
HN014_RS07775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HN014_RS07780	COG0194	GDP metabolic process
HN014_RS07785	COG1561	YicC-like family, N-terminal region
HN014_RS07800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HN014_RS07815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HN014_RS07820	COG0181	hydroxymethylbilane synthase activity
HN014_RS07830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HN014_RS07835	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HN014_RS07840	COG0408	coproporphyrinogen oxidase activity
HN014_RS07880	COG1131	(ABC) transporter
HN014_RS07885	COG0113	porphobilinogen synthase activity
HN014_RS07890	COG4335	DNA alkylation repair
HN014_RS07920	COG1253	flavin adenine dinucleotide binding
HN014_RS08105	COG3023	N-Acetylmuramoyl-L-alanine amidase
HN014_RS08225	COG0626	cystathionine gamma-synthase activity
HN014_RS08235	COG1381	Involved in DNA repair and RecF pathway recombination
HN014_RS08240	COG4771	TonB-dependent receptor
HN014_RS08255	COG0346	lactoylglutathione lyase activity
HN014_RS08315	COG1418	mRNA catabolic process
HN014_RS08335	COG1446	asparaginase
HN014_RS08340	COG2373	Large extracellular alpha-helical protein
HN014_RS08350	COG4953	penicillin-binding protein 1C
HN014_RS08365	COG2954	triphosphatase activity
HN014_RS08370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HN014_RS08375	COG0436	Aminotransferase
HN014_RS08385	COG1053	succinate dehydrogenase
HN014_RS08390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HN014_RS08395	COG2234	aminopeptidase activity
HN014_RS08395	COG4935	Belongs to the peptidase S8 family
HN014_RS08420	COG0123	including yeast histone deacetylase and acetoin utilization protein
HN014_RS08425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN014_RS08425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN014_RS08450	COG1619	proteins homologs of microcin C7 resistance protein MccF
HN014_RS08455	COG0792	nuclease activity
HN014_RS08475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HN014_RS08485	COG0784	Response regulator, receiver
HN014_RS08485	COG2205	protein histidine kinase activity
HN014_RS08505	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HN014_RS08520	COG0527	aspartate kinase activity
HN014_RS08530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HN014_RS08565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN014_RS08570	COG0662	Cupin 2, conserved barrel domain protein
HN014_RS08575	COG2239	Acts as a magnesium transporter
HN014_RS08580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HN014_RS08595	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HN014_RS08600	COG0583	DNA-binding transcription factor activity
HN014_RS08620	COG0196	riboflavin kinase activity
HN014_RS08625	COG0193	aminoacyl-tRNA hydrolase activity
HN014_RS08630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HN014_RS08635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN014_RS08645	COG3433	isochorismatase activity
HN014_RS08645	COG2226	methyltransferase
HN014_RS08645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN014_RS08680	COG3433	isochorismatase activity
HN014_RS08680	COG2226	methyltransferase
HN014_RS08680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN014_RS08695	COG1131	(ABC) transporter
HN014_RS08705	COG1629	transport
HN014_RS08730	COG0668	transmembrane transport
HN014_RS08745	COG0793	Belongs to the peptidase S41A family
HN014_RS08760	COG2095	MarC family integral membrane protein
HN014_RS08775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HN014_RS08775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HN014_RS08780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HN014_RS08785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HN014_RS08810	COG1278	Cold shock
HN014_RS08825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HN014_RS08830	COG1629	transport
HN014_RS08830	COG4206	TonB-dependent receptor
HN014_RS08840	COG0517	IMP dehydrogenase activity
HN014_RS09005	COG1309	transcriptional regulator
HN014_RS09035	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_RS09055	COG3104	oligopeptide transport
HN014_RS09060	COG3104	oligopeptide transport
HN014_RS09075	COG2333	competence protein COMEC
HN014_RS09075	COG0658	competence protein
HN014_RS09080	COG0791	NLP P60 protein
HN014_RS09085	COG2205	protein histidine kinase activity
HN014_RS09085	COG0784	Response regulator, receiver
HN014_RS09095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN014_RS09105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HN014_RS09115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN014_RS09130	COG0772	Belongs to the SEDS family
HN014_RS09135	COG0768	penicillin binding
HN014_RS09150	COG1077	Cell shape determining protein MreB Mrl
HN014_RS09155	COG0138	bifunctional purine biosynthesis protein purh
HN014_RS09185	COG0084	hydrolase, TatD family'
HN014_RS09190	COG0252	asparaginase activity
HN014_RS09200	COG0811	peptide transport
HN014_RS09250	COG4585	Histidine kinase
HN014_RS09280	COG0702	epimerase
HN014_RS09290	COG0702	epimerase
HN014_RS09295	COG4771	TonB-dependent receptor
HN014_RS09310	COG0295	cytidine deaminase activity
HN014_RS09335	COG2255	four-way junction helicase activity
HN014_RS09350	COG1842	Phage shock protein A
HN014_RS09360	COG1396	sequence-specific DNA binding
HN014_RS09370	COG0017	Asparaginyl-tRNA synthetase
HN014_RS09385	COG0233	cytoplasmic translational termination
HN014_RS09390	COG0528	UMP kinase activity
HN014_RS09395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HN014_RS09400	COG0052	Belongs to the universal ribosomal protein uS2 family
HN014_RS09405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HN014_RS09410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HN014_RS09420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN014_RS09420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN014_RS09455	COG0589	response to stress
HN014_RS09460	COG0779	Required for maturation of 30S ribosomal subunits
HN014_RS09465	COG0195	Participates in both transcription termination and antitermination
HN014_RS09470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HN014_RS09485	COG0437	4 iron, 4 sulfur cluster binding
HN014_RS09510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN014_RS09515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN014_RS09520	COG2255	four-way junction helicase activity
HN014_RS09525	COG2124	cytochrome p450
HN014_RS09530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HN014_RS09535	COG0280	phosphate acetyltransferase
HN014_RS09535	COG0281	malic enzyme
HN014_RS09540	COG0632	four-way junction helicase activity
HN014_RS09550	COG0509	glycine decarboxylation via glycine cleavage system
HN014_RS09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN014_RS09575	COG0109	protoheme IX farnesyltransferase activity
HN014_RS09580	COG1845	cytochrome c oxidase, subunit III
HN014_RS09600	COG1999	signal sequence binding
HN014_RS09605	COG2322	membrane
HN014_RS09615	COG1136	(ABC) transporter
HN014_RS09620	COG1136	(ABC) transporter
HN014_RS09620	COG0577	efflux transmembrane transporter activity
HN014_RS09625	COG0577	efflux transmembrane transporter activity
HN014_RS09625	COG1136	(ABC) transporter
HN014_RS09630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN014_RS09640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN014_RS09645	COG1214	PFAM Peptidase M22, glycoprotease
HN014_RS09660	COG1331	Highly conserved protein containing a thioredoxin domain
HN014_RS09685	COG0745	RESPONSE REGULATOR receiver
HN014_RS09685	COG2972	Histidine kinase
HN014_RS09690	COG3279	Response regulator of the LytR AlgR family
HN014_RS09695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HN014_RS09715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HN014_RS09725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HN014_RS09735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HN014_RS09740	COG0596	Alpha beta hydrolase
HN014_RS09755	COG1950	PFAM Membrane protein of
HN014_RS09760	COG0544	peptidyl-prolyl cis-trans isomerase activity
HN014_RS09770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HN014_RS09825	COG0076	glutamate decarboxylase activity
HN014_RS09855	COG1428	Deoxynucleoside kinase
HN014_RS09860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN014_RS09865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HN014_RS09915	COG2161	toxin-antitoxin pair type II binding
HN014_RS09920	COG4115	mRNA cleavage
HN014_RS10030	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HN014_RS10065	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HN014_RS10070	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HN014_RS10080	COG0022	dehydrogenase e1 component
HN014_RS10080	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_RS10085	COG2086	electron transfer activity
HN014_RS10090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HN014_RS10100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HN014_RS10105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HN014_RS10120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HN014_RS10130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HN014_RS10135	COG0402	S-adenosylhomocysteine deaminase activity
HN014_RS10140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HN014_RS10165	COG1428	Deoxynucleoside kinase
HN014_RS10205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HN014_RS10215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HN014_RS10220	COG0460	homoserine dehydrogenase
HN014_RS10220	COG0527	aspartate kinase activity
HN014_RS10225	COG1765	OsmC-like protein
HN014_RS10250	COG0175	sulfate reduction
HN014_RS10260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HN014_RS10265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HN014_RS10270	COG1648	precorrin-2 dehydrogenase activity
HN014_RS10270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HN014_RS10275	COG0492	ferredoxin-NADP+ reductase activity
HN014_RS10280	COG0633	Ferredoxin
HN014_RS10285	COG0646	methionine synthase
HN014_RS10285	COG1410	methionine synthase
HN014_RS10295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HN014_RS10310	COG1131	(ABC) transporter
HN014_RS10320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN014_RS10325	COG0156	8-amino-7-oxononanoate synthase activity
HN014_RS10330	COG0077	Prephenate dehydratase
HN014_RS10330	COG1605	Chorismate mutase
HN014_RS10335	COG0436	Aminotransferase
HN014_RS10340	COG0287	Prephenate dehydrogenase
HN014_RS10345	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HN014_RS10350	COG1162	GTPase activity
HN014_RS10355	COG1490	D-aminoacyl-tRNA deacylase activity
HN014_RS10375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HN014_RS10385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HN014_RS10415	COG0358	DNA primase activity
HN014_RS10425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HN014_RS10440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HN014_RS10445	COG2267	carboxylic ester hydrolase activity
HN014_RS10450	COG2001	Belongs to the MraZ family
HN014_RS10455	COG0275	rRNA processing
HN014_RS10465	COG0768	penicillin binding
HN014_RS10470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HN014_RS10475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HN014_RS10480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HN014_RS10485	COG0772	Belongs to the SEDS family
HN014_RS10490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HN014_RS10495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HN014_RS10510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HN014_RS10515	COG1610	YqeY-like protein
HN014_RS10595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN014_RS10925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN014_RS10940	COG4771	TonB-dependent receptor
HN014_RS10945	COG0702	epimerase
HN014_RS11015	COG3279	Response regulator of the LytR AlgR family
HN014_RS11020	COG3275	phosphorelay sensor kinase activity
HN014_RS11105	COG3971	2-oxopent-4-enoate hydratase activity
HN014_RS11150	COG0436	Aminotransferase
HN014_RS11155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HN014_RS11165	COG5441	Belongs to the UPF0261 family
HN014_RS11170	COG0531	amino acid
HN014_RS11180	COG1228	amidohydrolase
HN014_RS11185	COG4771	TonB-dependent receptor
HN014_RS11195	COG0745	RESPONSE REGULATOR receiver
HN014_RS11195	COG3292	Two component regulator propeller
HN014_RS11195	COG2205	protein histidine kinase activity
HN014_RS11205	COG4771	TonB-dependent receptor
HN014_RS11210	COG0702	epimerase
HN014_RS11240	COG0583	DNA-binding transcription factor activity
HN014_RS11265	COG1629	transport
HN014_RS11305	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_RS11310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_RS11315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_RS11335	COG4591	ABC-type transport system involved in lipoprotein release permease component
HN014_RS11340	COG0577	efflux transmembrane transporter activity
HN014_RS11340	COG1136	(ABC) transporter
HN014_RS11355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_RS11360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_RS11365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_RS11370	COG1073	alpha beta
HN014_RS11405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN014_RS11420	COG2211	Major facilitator Superfamily
HN014_RS11425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HN014_RS11445	COG1733	regulation of RNA biosynthetic process
HN014_RS11450	COG0655	NAD(P)H dehydrogenase (quinone) activity
HN014_RS11485	COG1595	DNA-templated transcription, initiation
HN014_RS11505	COG4585	Histidine kinase
HN014_RS11530	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HN014_RS11535	COG2224	Isocitrate lyase
HN014_RS11545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HN014_RS11550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HN014_RS11555	COG1185	polyribonucleotide nucleotidyltransferase activity
HN014_RS11560	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HN014_RS11570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HN014_RS11575	COG0191	fructose-bisphosphate aldolase activity
HN014_RS11595	COG2226	methyltransferase
HN014_RS11600	COG0569	domain protein
HN014_RS11615	COG0436	Aminotransferase
HN014_RS11620	COG3239	Fatty acid desaturase
HN014_RS11625	COG0357	Ribosomal RNA small subunit methyltransferase G
HN014_RS11635	COG1012	belongs to the aldehyde dehydrogenase family
HN014_RS11650	COG2967	ApaG domain
HN014_RS11665	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HN014_RS11670	COG1805	sodium ion transport
HN014_RS11675	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HN014_RS11680	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HN014_RS11685	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HN014_RS11695	COG4585	Histidine kinase
HN014_RS11700	COG2197	response regulator
HN014_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_RS11720	COG1309	transcriptional regulator
HN014_RS11740	COG1477	protein flavinylation
HN014_RS11745	COG2226	methyltransferase
HN014_RS11760	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HN014_RS11765	COG0501	Belongs to the peptidase M48B family
HN014_RS11815	COG0463	Glycosyl transferase, family 2
HN014_RS11825	COG2066	Belongs to the glutaminase family
HN014_RS11830	COG3340	Belongs to the peptidase S51 family
HN014_RS11850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HN014_RS11855	COG1404	Belongs to the peptidase S8 family
HN014_RS11865	COG3844	kynureninase activity
HN014_RS11885	COG4977	sequence-specific DNA binding
HN014_RS11890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN014_RS11895	COG1012	belongs to the aldehyde dehydrogenase family
HN014_RS11930	COG0433	COG0433 Predicted ATPase
HN014_RS11935	COG0251	oxidation-reduction process
HN014_RS11940	COG0602	queuosine metabolic process
HN014_RS11950	COG0367	asparagine synthase
HN014_RS11960	COG0187	DNA topoisomerase II activity
HN014_RS11975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HN014_RS11985	COG4452	Inner membrane protein CreD
HN014_RS12020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HN014_RS12035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN014_RS12045	COG2884	Cell division ATP-binding protein ftsE
HN014_RS12060	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HN014_RS12115	COG2197	response regulator
HN014_RS12120	COG4585	Histidine kinase
HN014_RS12125	COG3876	Protein conserved in bacteria
HN014_RS12155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HN014_RS12160	COG1115	amino acid carrier protein
HN014_RS12170	COG1960	acyl-CoA dehydrogenase activity
HN014_RS12175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HN014_RS12180	COG4974	Belongs to the 'phage' integrase family
HN014_RS12230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HN014_RS12235	COG0081	regulation of translation
HN014_RS12240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HN014_RS12245	COG0222	ribosome binding
HN014_RS12250	COG0085	RNA polymerase activity
HN014_RS12255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HN014_RS12270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HN014_RS12285	COG2885	chlorophyll binding
HN014_RS12290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HN014_RS12300	COG1482	cell wall glycoprotein biosynthetic process
HN014_RS12330	COG0561	phosphatase activity
HN014_RS12360	COG0326	Molecular chaperone. Has ATPase activity
HN014_RS12365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN014_RS12380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN014_RS12385	COG1136	(ABC) transporter
HN014_RS12430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HN014_RS12435	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HN014_RS12445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HN014_RS12460	COG0612	Peptidase, M16
HN014_RS12465	COG0339	signal peptide processing
HN014_RS12475	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HN014_RS12495	COG0519	Catalyzes the synthesis of GMP from XMP
HN014_RS12495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HN014_RS12500	COG3942	CHAP domain
HN014_RS12500	COG1388	LysM domain
HN014_RS12510	COG3530	Putative quorum-sensing-regulated virulence factor
HN014_RS12515	COG0019	diaminopimelate decarboxylase activity
HN014_RS12520	COG0045	succinate-CoA ligase (ADP-forming) activity
HN014_RS12545	COG0071	Belongs to the small heat shock protein (HSP20) family
HN014_RS12550	COG2201	protein-glutamate methylesterase activity
HN014_RS12555	COG0784	Response regulator, receiver
HN014_RS12555	COG2205	protein histidine kinase activity
HN014_RS12590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN014_RS12660	COG0300	oxidoreductase activity
HN014_RS12720	COG0840	transmembrane signaling receptor activity
HN014_RS12740	COG0488	(ABC) transporter
HN014_RS12745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HN014_RS12750	COG1183	phosphatidylcholine synthase activity
HN014_RS12755	COG1137	ATPase activity
HN014_RS12760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HN014_RS12765	COG0805	protein transport
HN014_RS12770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HN014_RS12770	COG0517	IMP dehydrogenase activity
HN014_RS12775	COG0514	ATP-dependent DNA helicase (RecQ)
HN014_RS12780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HN014_RS12800	COG1132	(ABC) transporter
HN014_RS12810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN014_RS12820	COG1862	Preprotein translocase
HN014_RS12825	COG0668	transmembrane transport
HN014_RS12830	COG2195	Cleaves the N-terminal amino acid of tripeptides
HN014_RS12850	COG0789	Transcriptional regulator
HN014_RS12860	COG0167	dihydroorotate dehydrogenase activity
HN014_RS12900	COG1840	ABC-type Fe3 transport system, periplasmic component
HN014_RS12910	COG3842	ATPase activity
HN014_RS12915	COG1528	Iron-storage protein
HN014_RS12920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS12940	COG0516	GMP reductase activity
HN014_RS12940	COG0517	IMP dehydrogenase activity
HN014_RS12945	COG4977	sequence-specific DNA binding
HN014_RS12945	COG1917	Cupin 2, conserved barrel domain protein
HN014_RS12960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN014_RS12970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN014_RS12975	COG0714	Associated with various cellular activities
HN014_RS12995	COG2885	chlorophyll binding
HN014_RS13000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HN014_RS13005	COG1051	belongs to the nudix hydrolase family
HN014_RS13005	COG1056	cytidyltransferase-related domain
HN014_RS13010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN014_RS13015	COG1397	ADP-ribosylglycohydrolase
HN014_RS13020	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HN014_RS13080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS13100	COG3275	phosphorelay sensor kinase activity
HN014_RS13105	COG3279	Response regulator of the LytR AlgR family
HN014_RS13170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN014_RS13205	COG0778	Nitroreductase
HN014_RS13210	COG1733	regulation of RNA biosynthetic process
HN014_RS13235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_RS13315	COG2207	Transcriptional regulator
HN014_RS13315	COG1609	Transcriptional regulator
HN014_RS13370	COG3279	Response regulator of the LytR AlgR family
HN014_RS13385	COG0284	orotidine-5'-phosphate decarboxylase activity
HN014_RS13390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HN014_RS13415	COG0788	formyltetrahydrofolate deformylase activity
HN014_RS13420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_RS13420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_RS13420	COG1703	isobutyryl-CoA mutase activity
HN014_RS13430	COG2972	Histidine kinase
HN014_RS13435	COG2204	response regulator
HN014_RS13445	COG1522	sequence-specific DNA binding
HN014_RS13455	COG1115	amino acid carrier protein
HN014_RS13460	COG2311	Membrane
HN014_RS13465	COG1595	DNA-templated transcription, initiation
HN014_RS13480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HN014_RS13515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HN014_RS13525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HN014_RS13525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN014_RS13530	COG1090	epimerase
HN014_RS13540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HN014_RS13545	COG0484	heat shock protein binding
HN014_RS13550	COG4152	abc transporter atp-binding protein
HN014_RS13560	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HN014_RS13560	COG3264	Mechanosensitive ion channel
HN014_RS13580	COG2326	polyphosphate kinase activity
HN014_RS13590	COG3781	membrane
HN014_RS13595	COG1506	peptidase
HN014_RS13600	COG1629	transport
HN014_RS13630	COG1595	DNA-templated transcription, initiation
HN014_RS13645	COG4771	TonB-dependent receptor
HN014_RS13675	COG0534	Mate efflux family protein
HN014_RS13685	COG0671	phosphoesterase, PA-phosphatase related
HN014_RS13695	COG0010	Belongs to the arginase family
HN014_RS13710	COG1703	isobutyryl-CoA mutase activity
HN014_RS13715	COG1764	response to oxidative stress
HN014_RS13760	COG0716	FMN binding
HN014_RS13775	COG1595	DNA-templated transcription, initiation
HN014_RS13785	COG0653	protein targeting
HN014_RS13805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HN014_RS13810	COG1216	Glycosyl transferase, family 2
HN014_RS13815	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN014_RS13820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN014_RS13825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN014_RS13830	COG1121	(ABC) transporter
HN014_RS13835	COG0803	Belongs to the bacterial solute-binding protein 9 family
HN014_RS13840	COG1321	iron dependent repressor
HN014_RS13840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN014_RS13850	COG0179	Fumarylacetoacetate (FAA) hydrolase
HN014_RS13860	COG1546	Belongs to the CinA family
HN014_RS13860	COG1058	Belongs to the CinA family
HN014_RS13865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HN014_RS13870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HN014_RS13880	COG0552	protein localization to endoplasmic reticulum
HN014_RS13885	COG0154	amidase activity
HN014_RS13890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN014_RS13910	COG3958	Transketolase
HN014_RS13920	COG0343	queuine tRNA-ribosyltransferase activity
HN014_RS13935	COG0825	malonyl-CoA metabolic process
HN014_RS13940	COG0305	Participates in initiation and elongation during chromosome replication
HN014_RS13960	COG1228	amidohydrolase
HN014_RS13975	COG2195	Cleaves the N-terminal amino acid of tripeptides
HN014_RS13990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HN014_RS14000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HN014_RS14005	COG0105	UTP biosynthetic process
HN014_RS14035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HN014_RS14045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HN014_RS14055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HN014_RS14085	COG0681	Belongs to the peptidase S26 family
HN014_RS14090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HN014_RS14100	COG1475	DNA binding
HN014_RS14105	COG1192	Involved in chromosome partitioning
HN014_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_RS14115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_RS14115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_RS14125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_RS14125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HN014_RS14135	COG0572	uridine kinase
HN014_RS14175	COG4232	protein-disulfide reductase activity
HN014_RS14180	COG4771	TonB-dependent receptor
HN014_RS14185	COG1271	oxidase subunit
HN014_RS14245	COG4771	TonB-dependent receptor
HN014_RS14260	COG2207	Transcriptional regulator
HN014_RS14265	COG2860	membrane
HN014_RS14350	COG3152	Membrane
HN014_RS14430	COG0714	Associated with various cellular activities
HN014_RS14480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HN014_RS14495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HN014_RS14530	COG2819	hydrolase of the alpha beta superfamily
HN014_RS14580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_RS14595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN014_RS14600	COG1741	Belongs to the pirin family
HN014_RS14615	COG0436	Aminotransferase
HN014_RS14620	COG2423	ornithine cyclodeaminase activity
HN014_RS14635	COG4977	sequence-specific DNA binding
HN014_RS14640	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HN014_RS14670	COG0519	Catalyzes the synthesis of GMP from XMP
HN014_RS14685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_RS14705	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_RS14770	COG3275	phosphorelay sensor kinase activity
HN014_RS14775	COG4555	ABC transporter
HN014_RS14790	COG1473	amidohydrolase
HN014_RS14830	COG0523	cobalamin synthesis protein
HN014_RS14835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HN014_RS14860	COG0456	acetyltransferase
HN014_RS14880	COG2382	esterase
HN014_RS14895	COG1280	lysine exporter protein (LysE YggA)
HN014_RS14910	COG1131	(ABC) transporter
HN014_RS14915	COG3655	Transcriptional regulator
HN014_RS15075	COG0024	Methionine aminopeptidase
HN014_RS15090	COG0596	Alpha beta hydrolase
HN014_RS15185	COG4941	Belongs to the sigma-70 factor family
HN014_RS15225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_RS15280	COG1231	oxidoreductase activity
HN014_RS15300	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_RS15325	COG4974	Belongs to the 'phage' integrase family
HN014_RS15355	COG0784	Response regulator, receiver
HN014_RS15355	COG2198	Histidine kinase
HN014_RS15355	COG5002	protein histidine kinase activity
HN014_RS15405	COG1629	transport
HN014_RS15405	COG4206	TonB-dependent receptor
HN014_RS15425	COG1960	acyl-CoA dehydrogenase activity
HN014_RS15430	COG0183	Belongs to the thiolase family
HN014_RS15435	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_RS15435	COG1024	Enoyl-CoA hydratase
HN014_RS15440	COG1846	Transcriptional regulator
HN014_RS15445	COG1022	Amp-dependent synthetase and ligase
HN014_RS15465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HN014_RS15465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN014_RS15485	COG1595	DNA-templated transcription, initiation
HN014_RS15490	COG1132	(ABC) transporter
HN014_RS15495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HN014_RS15500	COG0463	Glycosyl transferase, family 2
HN014_RS15510	COG0254	rRNA binding
HN014_RS15520	COG0747	negative chemotaxis
HN014_RS15525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN014_RS15555	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HN014_RS15560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HN014_RS15595	COG1120	ATPase activity
HN014_RS15600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HN014_RS15615	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HN014_RS15625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HN014_RS15630	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HN014_RS15650	COG1595	DNA-templated transcription, initiation
HN014_RS15680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HN014_RS15715	COG2885	chlorophyll binding
HN014_RS15730	COG0513	Belongs to the DEAD box helicase family
HN014_RS15745	COG0300	oxidoreductase activity
HN014_RS15750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HN014_RS15760	COG0488	(ABC) transporter
HN014_RS15790	COG0280	phosphate acetyltransferase
HN014_RS15790	COG0857	belongs to the CobB CobQ family
HN014_RS15795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HN014_RS15855	COG2356	endonuclease I
HN014_RS15860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HN014_RS15885	COG0069	glutamate synthase activity
HN014_RS15890	COG1473	amidohydrolase
HN014_RS15915	COG0009	L-threonylcarbamoyladenylate synthase
HN014_RS15945	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_RS15950	COG0626	cystathionine gamma-synthase activity
HN014_RS15955	COG1522	sequence-specific DNA binding
HN014_RS15985	COG1393	Belongs to the ArsC family
HN014_RS16005	COG3422	double-strand break repair
HN014_RS16010	COG2885	chlorophyll binding
HN014_RS16015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HN014_RS16030	COG0156	8-amino-7-oxononanoate synthase activity
HN014_RS16105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HN014_RS16120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HN014_RS16125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HN014_RS16195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN014_RS16220	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HN014_RS16225	COG3142	Participates in the control of copper homeostasis
HN014_RS16255	COG1136	(ABC) transporter
HN014_RS16265	COG0302	gtp cyclohydrolase
HN014_RS16290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN014_RS16295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HN014_RS16305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HN014_RS16315	COG4771	TonB-dependent receptor
HN014_RS16320	COG0012	GTP binding
HN014_RS16330	COG5002	protein histidine kinase activity
HN014_RS16330	COG2198	Histidine kinase
HN014_RS16330	COG0784	Response regulator, receiver
HN014_RS16380	COG0697	spore germination
HN014_RS16390	COG1017	nitric oxide dioxygenase activity
HN014_RS16390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HN014_RS16400	COG3279	Response regulator of the LytR AlgR family
HN014_RS16405	COG3275	phosphorelay sensor kinase activity
HN014_RS16470	COG0668	transmembrane transport
HN014_RS16485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HN014_RS16490	COG0861	Integral membrane protein TerC family
HN014_RS16510	COG1522	sequence-specific DNA binding
HN014_RS16515	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HN014_RS16610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HN014_RS16615	COG0583	DNA-binding transcription factor activity
HN014_RS16630	COG1169	isochorismate synthase
HN014_RS16635	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HN014_RS16645	COG2996	Protein conserved in bacteria
HN014_RS16685	COG1611	Belongs to the LOG family
HN014_RS16690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HN014_RS16715	COG0471	metal ion transport
HN014_RS16725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HN014_RS16745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HN014_RS16780	COG2204	response regulator
HN014_RS16785	COG1078	dGTPase activity
HN014_RS16790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN014_RS16795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN014_RS16795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HN014_RS16800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN014_RS16805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HN014_RS16815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HN014_RS16820	COG0612	Peptidase, M16
HN014_RS16825	COG1028	Short-chain dehydrogenase reductase Sdr
HN014_RS16845	COG2885	chlorophyll binding
HN014_RS16850	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HN014_RS16855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HN014_RS16860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HN014_RS16865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HN014_RS16865	COG0131	Imidazoleglycerol-phosphate dehydratase
HN014_RS16875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HN014_RS16880	COG0107	imidazoleglycerol-phosphate synthase activity
HN014_RS16885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HN014_RS16885	COG0140	phosphoribosyl-ATP diphosphatase activity
HN014_RS16905	COG0539	negative regulation of cytoplasmic translation
HN014_RS16910	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HN014_RS16915	COG0540	Belongs to the ATCase OTCase family
HN014_RS16925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS16930	COG1234	tRNA 3'-trailer cleavage
HN014_RS16935	COG0259	pyridoxamine-phosphate oxidase activity
HN014_RS16950	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HN014_RS17015	COG3279	Response regulator of the LytR AlgR family
HN014_RS17020	COG0438	transferase activity, transferring glycosyl groups
HN014_RS17045	COG0247	lactate metabolic process
HN014_RS17045	COG0277	FAD linked oxidase domain protein
HN014_RS17060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HN014_RS17065	COG1301	dicarboxylic acid transport
HN014_RS17075	COG3011	Protein conserved in bacteria
HN014_RS17085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HN014_RS17100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HN014_RS17105	COG0083	homoserine kinase activity
HN014_RS17110	COG0460	homoserine dehydrogenase
HN014_RS17110	COG0527	aspartate kinase activity
HN014_RS17120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HN014_RS17130	COG4974	Belongs to the 'phage' integrase family
HN014_RS17145	COG1404	Belongs to the peptidase S8 family
HN014_RS17150	COG1404	Belongs to the peptidase S8 family
HN014_RS17155	COG1404	Belongs to the peptidase S8 family
HN014_RS17165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HN014_RS17170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN014_RS17210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HN014_RS17215	COG1360	Flagellar Motor Protein
HN014_RS17245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HN014_RS17255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS17260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HN014_RS17270	COG1187	pseudouridine synthase activity
HN014_RS17285	COG0640	Transcriptional regulator
HN014_RS17295	COG1280	lysine exporter protein (LysE YggA)
HN014_RS17305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HN014_RS17365	COG3279	Response regulator of the LytR AlgR family
HN014_RS17385	COG1131	(ABC) transporter
HN014_RS17390	COG2972	Histidine kinase
HN014_RS17395	COG3279	Response regulator of the LytR AlgR family
HN014_RS17425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HN014_RS17445	COG0583	DNA-binding transcription factor activity
HN014_RS17450	COG2079	MmgE PrpD family protein
HN014_RS17465	COG2204	response regulator
HN014_RS17475	COG1136	(ABC) transporter
HN014_RS17485	COG0577	efflux transmembrane transporter activity
HN014_RS17545	COG2972	Histidine kinase
HN014_RS17575	COG3279	Response regulator of the LytR AlgR family
HN014_RS17585	COG3537	Alpha-1,2-mannosidase
HN014_RS17595	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HN014_RS17610	COG3537	Alpha-1,2-mannosidase
HN014_RS17615	COG1446	asparaginase
HN014_RS17620	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HN014_RS17665	COG1629	transport
HN014_RS17700	COG0596	Alpha beta hydrolase
HN014_RS17715	COG0823	Involved in the tonB-independent uptake of proteins
HN014_RS17715	COG1506	peptidase
HN014_RS17715	COG4946	Tricorn protease homolog
HN014_RS17755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HN014_RS17770	COG4221	oxidoreductase activity
HN014_RS17805	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HN014_RS17815	COG0640	Transcriptional regulator
HN014_RS17820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN014_RS17820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HN014_RS17825	COG2814	Major facilitator Superfamily
HN014_RS17830	COG1104	cysteine desulfurase activity
HN014_RS17840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN014_RS17845	COG2274	protein secretion by the type I secretion system
HN014_RS17865	COG2205	protein histidine kinase activity
HN014_RS17865	COG2198	Histidine kinase
HN014_RS17865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN014_RS17865	COG0784	Response regulator, receiver
HN014_RS17885	COG3047	cAMP biosynthetic process
HN014_RS17890	COG4733	cellulase activity
HN014_RS17890	COG5297	Belongs to the glycosyl hydrolase family 6
HN014_RS17910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HN014_RS17920	COG1846	Transcriptional regulator
HN014_RS17990	COG3279	Response regulator of the LytR AlgR family
HN014_RS18005	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HN014_RS18020	COG4628	conserved protein (DUF2132)
HN014_RS18040	COG3279	Response regulator of the LytR AlgR family
HN014_RS18045	COG2972	Histidine kinase
HN014_RS18080	COG4821	SIS domain
HN014_RS18150	COG0730	response to heat
HN014_RS18155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HN014_RS18165	COG1522	sequence-specific DNA binding
HN014_RS18205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN014_RS18210	COG2885	chlorophyll binding
HN014_RS18225	COG2270	Major facilitator Superfamily
HN014_RS18265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HN014_RS18270	COG0076	glutamate decarboxylase activity
HN014_RS18285	COG0488	(ABC) transporter
HN014_RS18295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HN014_RS18305	COG2304	oxidoreductase activity
HN014_RS18410	COG2072	flavoprotein involved in K transport
HN014_RS18415	COG1595	DNA-templated transcription, initiation
HN014_RS18460	COG3011	Protein conserved in bacteria
HN014_RS18475	COG4948	Mandelate Racemase Muconate Lactonizing
HN014_RS18480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HN014_RS18485	COG1575	Belongs to the MenA family. Type 1 subfamily
HN014_RS18505	COG0668	transmembrane transport
HN014_RS18515	COG1480	7TM receptor with intracellular HD hydrolase
HN014_RS18520	COG0183	Belongs to the thiolase family
HN014_RS18525	COG0791	NLP P60 protein
HN014_RS18535	COG1609	Transcriptional regulator
HN014_RS18550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HN014_RS18560	COG1045	serine acetyltransferase
HN014_RS18570	COG0514	ATP-dependent DNA helicase (RecQ)
HN014_RS18585	COG2823	Periplasmic or secreted lipoprotein
HN014_RS18585	COG1652	LysM domain
HN014_RS18605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HN014_RS18610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HN014_RS18655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HN014_RS18660	COG1696	Membrane protein involved in D-alanine export
HN014_RS18670	COG0110	maltose O-acetyltransferase activity
HN014_RS18675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN014_RS18695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HN014_RS18700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN014_RS18715	COG0438	transferase activity, transferring glycosyl groups
HN014_RS18720	COG5434	Belongs to the glycosyl hydrolase 28 family
HN014_RS18725	COG0367	asparagine synthase
HN014_RS18730	COG1442	glycosyl transferase family 8
HN014_RS18730	COG1216	Glycosyl transferase, family 2
HN014_RS18745	COG0438	transferase activity, transferring glycosyl groups
HN014_RS18765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HN014_RS18770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN014_RS18775	COG0022	dehydrogenase e1 component
HN014_RS18815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HN014_RS18820	COG1193	negative regulation of DNA recombination
HN014_RS18825	COG4935	Belongs to the peptidase S8 family
HN014_RS18825	COG1404	Belongs to the peptidase S8 family
HN014_RS18830	COG1573	uracil-dna glycosylase
HN014_RS18850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN014_RS18855	COG0673	inositol 2-dehydrogenase activity
HN014_RS18865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HN014_RS18880	COG0415	Belongs to the DNA photolyase family
HN014_RS18885	COG0583	DNA-binding transcription factor activity
HN014_RS18890	COG2986	histidine ammonia-lyase
HN014_RS18900	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HN014_RS18905	COG0010	Belongs to the arginase family
HN014_RS18930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HN014_RS18950	COG0514	ATP-dependent DNA helicase (RecQ)
HN014_RS18955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HN014_RS18965	COG1678	Uncharacterized ACR, COG1678
HN014_RS18970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HN014_RS18995	COG3292	Two component regulator propeller
HN014_RS18995	COG2205	protein histidine kinase activity
HN014_RS18995	COG0745	RESPONSE REGULATOR receiver
HN014_RS19040	COG2311	Membrane
HN014_RS19055	COG2205	protein histidine kinase activity
HN014_RS19060	COG3279	Response regulator of the LytR AlgR family
HN014_RS19080	COG0076	glutamate decarboxylase activity
HN014_RS19115	COG3279	Response regulator of the LytR AlgR family
HN014_RS19120	COG3275	phosphorelay sensor kinase activity
HN014_RS19125	COG3275	phosphorelay sensor kinase activity
HN014_RS19135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN014_RS19180	COG2207	Transcriptional regulator
HN014_RS19180	COG0662	Cupin 2, conserved barrel domain protein
HN014_RS19190	COG4585	Histidine kinase
HN014_RS19200	COG0124	histidyl-tRNA synthetase
HN014_RS19205	COG0577	efflux transmembrane transporter activity
HN014_RS19220	COG0359	binds to the 23S rRNA
HN014_RS19225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HN014_RS19230	COG0360	Binds together with S18 to 16S ribosomal RNA
HN014_RS19235	COG3279	Response regulator of the LytR AlgR family
HN014_RS19240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HN014_RS19265	COG1295	ribonuclease BN
HN014_RS19275	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HN014_RS19285	COG0424	maF-like protein
HN014_RS19295	COG2154	pterin-4-alpha-carbinolamine dehydratase
HN014_RS19300	COG0217	transcriptional regulatory protein
HN014_RS19315	COG1012	belongs to the aldehyde dehydrogenase family
HN014_RS19330	COG0318	PFAM AMP-dependent synthetase and ligase
HN014_RS19335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN014_RS19360	COG1454	alcohol dehydrogenase
HN014_RS19370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN014_RS19410	COG1472	Belongs to the glycosyl hydrolase 3 family
HN014_RS19420	COG0247	lactate metabolic process
HN014_RS19420	COG2181	nitrate reductase activity
HN014_RS19430	COG2181	nitrate reductase activity
HN014_RS19430	COG0247	lactate metabolic process
HN014_RS19435	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HN014_RS19440	COG0860	N-Acetylmuramoyl-L-alanine amidase
HN014_RS19450	COG0251	oxidation-reduction process
HN014_RS19460	COG0753	catalase activity
HN014_RS19475	COG3256	nitric oxide reductase
HN014_RS19480	COG0205	6-phosphofructokinase activity
HN014_RS19490	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HN014_RS19500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HN014_RS19525	COG0628	permease
HN014_RS19580	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HN014_RS19590	COG1473	amidohydrolase
HN014_RS19605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN014_RS19605	COG0723	plastoquinol--plastocyanin reductase activity
HN014_RS19620	COG0302	gtp cyclohydrolase
HN014_RS19625	COG1136	(ABC) transporter
HN014_RS19645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HN014_RS19710	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HN014_RS19725	COG0386	Belongs to the glutathione peroxidase family
HN014_RS19780	COG0688	phosphatidylethanolamine metabolic process
HN014_RS19805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HN014_RS19810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HN014_RS19820	COG0826	peptidase U32
HN014_RS19840	COG1492	cobalamin metabolic process
HN014_RS19875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN014_RS19880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HN014_RS19880	COG1648	precorrin-2 dehydrogenase activity
HN014_RS19895	COG1797	cobyrinic acid a,c-diamide synthase activity
HN014_RS19900	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HN014_RS19995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HN014_RS20010	COG1191	sigma factor activity
HN014_RS20030	COG1233	COG1233 Phytoene dehydrogenase and related
HN014_RS20065	COG3275	phosphorelay sensor kinase activity
HN014_RS20080	COG3279	Response regulator of the LytR AlgR family
HN014_RS20105	COG1733	regulation of RNA biosynthetic process
HN014_RS20115	COG3279	Response regulator of the LytR AlgR family
HN014_RS20140	COG1522	sequence-specific DNA binding
HN014_RS20150	COG1280	lysine exporter protein (LysE YggA)
HN014_RS20185	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HN014_RS20210	COG0778	Nitroreductase
HN014_RS20225	COG2096	Adenosyltransferase
HN014_RS20240	COG2949	membrane
HN014_RS20245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HN014_RS20245	COG1333	cytochrome c biogenesis protein
HN014_RS20260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HN014_RS20275	COG1607	acyl-coa hydrolase
HN014_RS20280	COG0778	Nitroreductase
HN014_RS20285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS20290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HN014_RS20295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN014_RS20295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN014_RS20310	COG1674	ftsk spoiiie
HN014_RS20315	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HN014_RS20335	COG0450	alkyl hydroperoxide reductase
HN014_RS20340	COG2205	protein histidine kinase activity
HN014_RS20340	COG0784	Response regulator, receiver
HN014_RS20345	COG0626	cystathionine gamma-synthase activity
HN014_RS20350	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HN014_RS20365	COG2234	aminopeptidase activity
HN014_RS20410	COG0791	NLP P60 protein
HN014_RS20430	COG0784	Response regulator, receiver
HN014_RS20430	COG2205	protein histidine kinase activity
HN014_RS20435	COG2205	protein histidine kinase activity
HN014_RS20435	COG0784	Response regulator, receiver
HN014_RS20450	COG0542	response to heat
HN014_RS20485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HN014_RS20490	COG0542	response to heat
HN014_RS20500	COG1418	mRNA catabolic process
HN014_RS20520	COG0562	UDP-galactopyranose mutase
HN014_RS20525	COG0438	transferase activity, transferring glycosyl groups
HN014_RS20530	COG0739	heme binding
HN014_RS20540	COG1104	cysteine desulfurase activity
HN014_RS20580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN014_RS20605	COG0116	Belongs to the methyltransferase superfamily
HN014_RS20655	COG1363	Peptidase, m42
HN014_RS20660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HN014_RS20665	COG0745	RESPONSE REGULATOR receiver
HN014_RS20670	COG5002	protein histidine kinase activity
HN014_RS20675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN014_RS20700	COG0783	Belongs to the Dps family
HN014_RS20730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN014_RS20735	COG0705	Rhomboid family
HN014_RS20745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HN014_RS20760	COG0405	Gamma-glutamyltransferase
HN014_RS20780	COG0443	Heat shock 70 kDa protein
HN014_RS20785	COG1760	l-serine dehydratase
HN014_RS20800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HN014_RS20805	COG0564	pseudouridine synthase activity
HN014_RS20835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HN014_RS20840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HN014_RS20845	COG0066	3-isopropylmalate dehydratase activity
HN014_RS20850	COG0473	3-isopropylmalate dehydrogenase activity
HN014_RS20855	COG2363	Small membrane protein
HN014_RS20885	COG3012	SEC-C Motif Domain Protein
HN014_RS20910	COG4251	negative regulation of phosphorylation
HN014_RS20920	COG0745	RESPONSE REGULATOR receiver
HN014_RS20925	COG2201	protein-glutamate methylesterase activity
HN014_RS20935	COG0511	ligase activity, forming carbon-carbon bonds
HN014_RS20940	COG0439	Biotin carboxylase
HN014_RS20945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HN014_RS20955	COG0165	Argininosuccinate lyase
HN014_RS20965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HN014_RS20975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN014_RS20985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HN014_RS20990	COG0137	argininosuccinate synthase activity
HN014_RS21000	COG1506	peptidase
HN014_RS21005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HN014_RS21010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HN014_RS21020	COG0028	Belongs to the TPP enzyme family
HN014_RS21025	COG0129	dihydroxy-acid dehydratase activity
HN014_RS21030	COG2197	response regulator
HN014_RS21035	COG4585	Histidine kinase
HN014_RS21055	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HN014_RS21060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HN014_RS21065	COG1914	H( )-stimulated, divalent metal cation uptake system
HN014_RS21075	COG1222	aaa ATPase
HN014_RS21135	COG3501	Rhs element vgr protein
HN014_RS21255	COG0673	inositol 2-dehydrogenase activity
HN014_RS21260	COG3292	Two component regulator propeller
HN014_RS21260	COG2205	protein histidine kinase activity
HN014_RS21260	COG0745	RESPONSE REGULATOR receiver
HN014_RS21265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HN014_RS21270	COG1702	phosphate starvation-inducible protein PhoH
HN014_RS21295	COG0592	DNA-directed DNA polymerase activity
HN014_RS21325	COG0069	glutamate synthase activity
HN014_RS21325	COG0070	glutamate synthase
HN014_RS21325	COG0067	glutamate synthase
HN014_RS21335	COG0004	ammonium transporteR
HN014_RS21340	COG0784	Response regulator, receiver
HN014_RS21340	COG2205	protein histidine kinase activity
HN014_RS21340	COG5002	protein histidine kinase activity
HN014_RS21345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HN014_RS21355	COG0641	radical SAM
HN014_RS21400	COG0612	Peptidase, M16
HN014_RS21410	COG0606	chelatase, subunit chli
HN014_RS21415	COG0527	aspartate kinase activity
HN014_RS21430	COG3590	peptidase
HN014_RS21455	COG2205	protein histidine kinase activity
HN014_RS21455	COG4999	Histidine kinase
HN014_RS21455	COG3437	response regulator, receiver
HN014_RS21455	COG3850	Histidine kinase
HN014_RS21485	COG0205	6-phosphofructokinase activity
HN014_RS21490	COG2274	protein secretion by the type I secretion system
HN014_RS21505	COG0784	Response regulator, receiver
HN014_RS21505	COG2198	Histidine kinase
HN014_RS21505	COG5002	protein histidine kinase activity
HN014_RS21525	COG0037	tRNA processing
HN014_RS21540	COG0431	NADPH-dependent FMN reductase
HN014_RS21545	COG0523	cobalamin synthesis protein
HN014_RS21565	COG0513	Belongs to the DEAD box helicase family
HN014_RS21570	COG1988	membrane-bound metal-dependent
HN014_RS21575	COG1132	(ABC) transporter
HN014_RS21600	COG4977	sequence-specific DNA binding
HN014_RS21605	COG0612	Peptidase, M16
HN014_RS21620	COG4771	TonB-dependent receptor
HN014_RS21645	COG0308	aminopeptidase N
HN014_RS21660	COG1522	sequence-specific DNA binding
HN014_RS21675	COG3279	Response regulator of the LytR AlgR family
HN014_RS21680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN014_RS21700	COG3279	Response regulator of the LytR AlgR family
HN014_RS21705	COG3275	phosphorelay sensor kinase activity
HN014_RS21715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HN014_RS21750	COG0542	response to heat
HN014_RS21760	COG1309	transcriptional regulator
HN014_RS21790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HN014_RS21795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HN014_RS21800	COG0673	inositol 2-dehydrogenase activity
HN014_RS21805	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN014_RS21825	COG2176	DNA-directed DNA polymerase activity
HN014_RS21830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN014_RS21835	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HN014_RS21865	COG4974	Belongs to the 'phage' integrase family
HN014_RS21955	COG0563	adenylate kinase activity
HN014_RS21995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HN014_RS22000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HN014_RS22005	COG0497	DNA recombination
HN014_RS22035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN014_RS22050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HN014_RS22060	COG2890	protein-(glutamine-N5) methyltransferase activity
HN014_RS22075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN014_RS22075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN014_RS22090	COG1739	Uncharacterized protein family UPF0029
HN014_RS22095	COG0824	Thioesterase
HN014_RS22130	COG1192	Involved in chromosome partitioning
HN014_RS22180	COG0629	single-stranded DNA binding
HN014_RS22285	COG1192	Involved in chromosome partitioning
HN014_RS22300	COG3328	transposase activity
HN014_RS22345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HN014_RS22530	COG2003	Belongs to the UPF0758 family