locus-tag	class	description
MW290_RS00040	COG5507	3-demethylubiquinone-9 3-methyltransferase
MW290_RS00050	COG4214	carbohydrate transport
MW290_RS00075	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS00080	COG3246	L-lysine catabolic process to acetate
MW290_RS00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
MW290_RS00090	COG0583	DNA-binding transcription factor activity
MW290_RS00095	COG2197	response regulator
MW290_RS00100	COG0583	DNA-binding transcription factor activity
MW290_RS00115	COG1335	isochorismatase
MW290_RS00125	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MW290_RS00155	COG2814	Major facilitator Superfamily
MW290_RS00190	COG2814	Major facilitator Superfamily
MW290_RS00195	COG2205	protein histidine kinase activity
MW290_RS00235	COG2223	nitrite transmembrane transporter activity
MW290_RS00260	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS00285	COG4608	Belongs to the ABC transporter superfamily
MW290_RS00295	COG1473	amidohydrolase
MW290_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS00325	COG0583	DNA-binding transcription factor activity
MW290_RS00355	COG0583	DNA-binding transcription factor activity
MW290_RS00365	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS00370	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS00375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MW290_RS00390	COG0066	3-isopropylmalate dehydratase activity
MW290_RS00395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MW290_RS00405	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS00430	COG1595	DNA-templated transcription, initiation
MW290_RS00450	COG0840	transmembrane signaling receptor activity
MW290_RS00455	COG0753	catalase activity
MW290_RS00460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MW290_RS00480	COG2010	Cytochrome c
MW290_RS00480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MW290_RS00485	COG2267	carboxylic ester hydrolase activity
MW290_RS00505	COG1228	amidohydrolase
MW290_RS00510	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MW290_RS00535	COG0154	amidase activity
MW290_RS00585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MW290_RS00590	COG4191	Histidine kinase
MW290_RS00590	COG0784	Response regulator, receiver
MW290_RS00595	COG0673	inositol 2-dehydrogenase activity
MW290_RS00605	COG1879	ABC-type sugar transport system periplasmic component
MW290_RS00610	COG1172	Belongs to the binding-protein-dependent transport system permease family
MW290_RS00615	COG1129	ABC transporter
MW290_RS00620	COG1940	carbohydrate kinase activity
MW290_RS00635	COG0405	Gamma-glutamyltransferase
MW290_RS00645	COG0840	transmembrane signaling receptor activity
MW290_RS00650	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MW290_RS00655	COG1074	ATP-dependent DNA helicase activity
MW290_RS00660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MW290_RS00675	COG3550	peptidyl-serine autophosphorylation
MW290_RS00715	COG1309	transcriptional regulator
MW290_RS00725	COG0673	inositol 2-dehydrogenase activity
MW290_RS00750	COG2203	Gaf domain
MW290_RS00750	COG3706	GGDEF domain
MW290_RS00750	COG4251	negative regulation of phosphorylation
MW290_RS00750	COG5001	Diguanylate cyclase
MW290_RS00755	COG5001	Diguanylate cyclase
MW290_RS00755	COG3300	MHYT domain
MW290_RS00770	COG3002	Belongs to the UPF0753 family
MW290_RS00775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MW290_RS00810	COG4794	Type iii secretion
MW290_RS00825	COG4566	intracellular signal transduction
MW290_RS00870	COG4669	(LipO)protein
MW290_RS00895	COG4789	Type iii secretion
MW290_RS00900	COG0741	lytic transglycosylase activity
MW290_RS00935	COG5002	protein histidine kinase activity
MW290_RS00950	COG3493	citrate carrier protein
MW290_RS00955	COG2843	Capsule synthesis protein
MW290_RS00990	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MW290_RS00995	COG2204	response regulator
MW290_RS01010	COG5002	protein histidine kinase activity
MW290_RS01010	COG0784	Response regulator, receiver
MW290_RS01010	COG2205	protein histidine kinase activity
MW290_RS01025	COG0583	DNA-binding transcription factor activity
MW290_RS01035	COG0583	DNA-binding transcription factor activity
MW290_RS01040	COG0523	cobalamin synthesis protein
MW290_RS01060	COG0840	transmembrane signaling receptor activity
MW290_RS01065	COG2200	EAL domain
MW290_RS01065	COG2199	diguanylate cyclase activity
MW290_RS01165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS01170	COG2205	protein histidine kinase activity
MW290_RS01180	COG3459	Glycosyltransferase 36 associated
MW290_RS01215	COG3243	poly(R)-hydroxyalkanoic acid synthase
MW290_RS01220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MW290_RS01230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MW290_RS01235	COG0842	Transport permease protein
MW290_RS01235	COG1129	ABC transporter
MW290_RS01240	COG0842	Transport permease protein
MW290_RS01250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MW290_RS01285	COG0840	transmembrane signaling receptor activity
MW290_RS01300	COG1595	DNA-templated transcription, initiation
MW290_RS01305	COG3712	iron ion homeostasis
MW290_RS01325	COG3486	L-lysine 6-monooxygenase (NADPH) activity
MW290_RS01365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MW290_RS01405	COG1595	DNA-templated transcription, initiation
MW290_RS01415	COG1404	Belongs to the peptidase S8 family
MW290_RS01420	COG0174	glutamine synthetase
MW290_RS01425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS01435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MW290_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS01455	COG3842	ATPase activity
MW290_RS01460	COG1176	ABC-type spermidine putrescine transport system, permease component I
MW290_RS01465	COG1177	transmembrane transport
MW290_RS01480	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS01495	COG1309	transcriptional regulator
MW290_RS01530	COG1475	DNA binding
MW290_RS01540	COG3039	Transposase
MW290_RS01545	COG2197	response regulator
MW290_RS01585	COG2003	Belongs to the UPF0758 family
MW290_RS01615	COG4974	Belongs to the 'phage' integrase family
MW290_RS01620	COG0582	viral genome integration into host DNA
MW290_RS01625	COG4974	Belongs to the 'phage' integrase family
MW290_RS01660	COG0596	Alpha beta hydrolase
MW290_RS01695	COG1234	tRNA 3'-trailer cleavage
MW290_RS01715	COG0583	DNA-binding transcription factor activity
MW290_RS01815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS01840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MW290_RS01850	COG0542	response to heat
MW290_RS01855	COG0071	Belongs to the small heat shock protein (HSP20) family
MW290_RS01875	COG0840	transmembrane signaling receptor activity
MW290_RS01905	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MW290_RS01910	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MW290_RS01915	COG0583	DNA-binding transcription factor activity
MW290_RS01930	COG0582	viral genome integration into host DNA
MW290_RS01940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MW290_RS01950	COG0776	regulation of translation
MW290_RS01970	COG0322	excinuclease ABC activity
MW290_RS01980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MW290_RS01985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS01985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MW290_RS01995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MW290_RS02000	COG0167	dihydroorotate dehydrogenase activity
MW290_RS02020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MW290_RS02035	COG1454	alcohol dehydrogenase
MW290_RS02040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MW290_RS02045	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS02070	COG4566	intracellular signal transduction
MW290_RS02095	COG3132	Protein of unknown function, DUF480
MW290_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS02120	COG1072	(Pantothenic acid kinase))
MW290_RS02130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MW290_RS02135	COG0509	glycine decarboxylation via glycine cleavage system
MW290_RS02140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MW290_RS02140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MW290_RS02145	COG1760	l-serine dehydratase
MW290_RS02175	COG0515	serine threonine protein kinase
MW290_RS02175	COG2815	serine threonine protein kinase
MW290_RS02245	COG0473	3-isopropylmalate dehydrogenase activity
MW290_RS02275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MW290_RS02305	COG3842	ATPase activity
MW290_RS02315	COG1349	DNA-binding transcription factor activity
MW290_RS02340	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MW290_RS02345	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MW290_RS02360	COG2326	polyphosphate kinase activity
MW290_RS02375	COG4948	Mandelate Racemase Muconate Lactonizing
MW290_RS02380	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS02405	COG3618	amidohydrolase
MW290_RS02415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MW290_RS02435	COG1396	sequence-specific DNA binding
MW290_RS02440	COG3550	peptidyl-serine autophosphorylation
MW290_RS02450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MW290_RS02455	COG1024	Enoyl-CoA hydratase
MW290_RS02510	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MW290_RS02515	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MW290_RS02520	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MW290_RS02525	COG1063	alcohol dehydrogenase
MW290_RS02530	COG0500	methyltransferase
MW290_RS02535	COG0142	geranyltranstransferase activity
MW290_RS02550	COG5001	Diguanylate cyclase
MW290_RS02550	COG4251	negative regulation of phosphorylation
MW290_RS02550	COG3706	GGDEF domain
MW290_RS02550	COG2203	Gaf domain
MW290_RS02555	COG0840	transmembrane signaling receptor activity
MW290_RS02585	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MW290_RS02590	COG1562	ergosterol biosynthetic process
MW290_RS02595	COG1233	COG1233 Phytoene dehydrogenase and related
MW290_RS02615	COG0861	Integral membrane protein TerC family
MW290_RS02620	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MW290_RS02640	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MW290_RS02645	COG0644	oxidoreductase
MW290_RS02650	COG2211	Major facilitator Superfamily
MW290_RS02655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MW290_RS02690	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MW290_RS02695	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
MW290_RS02700	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
MW290_RS02730	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MW290_RS02750	COG1429	ligase activity, forming nitrogen-metal bonds
MW290_RS02760	COG0784	Response regulator, receiver
MW290_RS02760	COG4191	Histidine kinase
MW290_RS02775	COG2172	sigma factor antagonist activity
MW290_RS02780	COG1366	Belongs to the anti-sigma-factor antagonist family
MW290_RS02785	COG1366	Belongs to the anti-sigma-factor antagonist family
MW290_RS02795	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS02800	COG0784	Response regulator, receiver
MW290_RS02800	COG4191	Histidine kinase
MW290_RS02850	COG2205	protein histidine kinase activity
MW290_RS02880	COG1024	Enoyl-CoA hydratase
MW290_RS02890	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS02900	COG1960	acyl-CoA dehydrogenase activity
MW290_RS02905	COG1960	acyl-CoA dehydrogenase activity
MW290_RS02910	COG0604	alcohol dehydrogenase
MW290_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS02925	COG0371	Dehydrogenase
MW290_RS02930	COG3958	Transketolase
MW290_RS02935	COG3959	Transketolase, thiamine diphosphate binding domain
MW290_RS02950	COG1172	Belongs to the binding-protein-dependent transport system permease family
MW290_RS02955	COG0559	Belongs to the binding-protein-dependent transport system permease family
MW290_RS02965	COG0596	Alpha beta hydrolase
MW290_RS03030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MW290_RS03045	COG0702	epimerase
MW290_RS03120	COG2948	multi-organism process
MW290_RS03150	COG1254	Belongs to the acylphosphatase family
MW290_RS03190	COG4372	Transposase
MW290_RS03210	COG2304	oxidoreductase activity
MW290_RS03225	COG0583	DNA-binding transcription factor activity
MW290_RS03255	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS03260	COG1960	acyl-CoA dehydrogenase activity
MW290_RS03275	COG5002	protein histidine kinase activity
MW290_RS03275	COG2205	protein histidine kinase activity
MW290_RS03275	COG0784	Response regulator, receiver
MW290_RS03280	COG2205	protein histidine kinase activity
MW290_RS03280	COG3437	response regulator, receiver
MW290_RS03280	COG3850	Histidine kinase
MW290_RS03280	COG4999	Histidine kinase
MW290_RS03320	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS03325	COG1250	3-hydroxyacyl-CoA dehydrogenase
MW290_RS03325	COG1024	Enoyl-CoA hydratase
MW290_RS03330	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS03415	COG0625	glutathione transferase activity
MW290_RS03450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MW290_RS03490	COG2982	Protein involved in outer membrane biogenesis
MW290_RS03500	COG0784	Response regulator, receiver
MW290_RS03500	COG2198	Histidine kinase
MW290_RS03500	COG2205	protein histidine kinase activity
MW290_RS03565	COG3436	PFAM IS66 Orf2 family protein
MW290_RS03570	COG4372	Transposase
MW290_RS03575	COG3012	SEC-C Motif Domain Protein
MW290_RS03605	COG0789	Transcriptional regulator
MW290_RS03630	COG0723	plastoquinol--plastocyanin reductase activity
MW290_RS03635	COG2326	polyphosphate kinase activity
MW290_RS03640	COG2217	Heavy metal translocating P-type atpase
MW290_RS03645	COG2132	Multicopper oxidase
MW290_RS03655	COG0477	Major facilitator Superfamily
MW290_RS03710	COG2433	Pfam Transposase IS66
MW290_RS03760	COG2194	sulfuric ester hydrolase activity
MW290_RS03780	COG0789	Transcriptional regulator
MW290_RS03880	COG1136	(ABC) transporter
MW290_RS03885	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MW290_RS03900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MW290_RS03910	COG2217	Heavy metal translocating P-type atpase
MW290_RS03920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MW290_RS03925	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MW290_RS03935	COG4716	Myosin-crossreactive antigen
MW290_RS03940	COG0789	Transcriptional regulator
MW290_RS03945	COG4869	propanediol catabolic process
MW290_RS03955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MW290_RS04000	COG3174	membrane
MW290_RS04040	COG2132	Multicopper oxidase
MW290_RS04075	COG3344	reverse transcriptase
MW290_RS04095	COG5002	protein histidine kinase activity
MW290_RS04115	COG0789	Transcriptional regulator
MW290_RS04120	COG2217	Heavy metal translocating P-type atpase
MW290_RS04130	COG0789	Transcriptional regulator
MW290_RS04160	COG0798	PFAM Bile acid sodium symporter
MW290_RS04225	COG0642	Histidine kinase
MW290_RS04235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MW290_RS04245	COG2847	Copper chaperone PCu(A)C
MW290_RS04250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MW290_RS04265	COG0789	Transcriptional regulator
MW290_RS04345	COG1139	Iron-sulfur cluster binding protein
MW290_RS04350	COG0247	lactate metabolic process
MW290_RS04355	COG1620	l-lactate permease
MW290_RS04360	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MW290_RS04365	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MW290_RS04370	COG1294	oxidase, subunit
MW290_RS04375	COG1271	oxidase subunit
MW290_RS04385	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS04390	COG0183	Belongs to the thiolase family
MW290_RS04395	COG3243	poly(R)-hydroxyalkanoic acid synthase
MW290_RS04400	COG1252	NADH dehydrogenase
MW290_RS04405	COG0596	Alpha beta hydrolase
MW290_RS04410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MW290_RS04415	COG0508	dehydrogenase complex catalyzes the overall conversion of
MW290_RS04425	COG2186	Transcriptional regulator
MW290_RS04430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MW290_RS04470	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS04470	COG3321	synthase
MW290_RS04470	COG0604	alcohol dehydrogenase
MW290_RS04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS04500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MW290_RS04515	COG0071	Belongs to the small heat shock protein (HSP20) family
MW290_RS04560	COG3436	PFAM IS66 Orf2 family protein
MW290_RS04565	COG4372	Transposase
MW290_RS04585	COG3039	Transposase
MW290_RS04630	COG1652	LysM domain
MW290_RS04635	COG3039	Transposase
MW290_RS04650	COG2205	protein histidine kinase activity
MW290_RS04650	COG5002	protein histidine kinase activity
MW290_RS04650	COG0784	Response regulator, receiver
MW290_RS04670	COG3039	Transposase
MW290_RS04690	COG3685	Protein conserved in bacteria
MW290_RS04700	COG4372	Transposase
MW290_RS04735	COG2826	transposase and inactivated derivatives, IS30 family
MW290_RS04770	COG0840	transmembrane signaling receptor activity
MW290_RS04795	COG5001	Diguanylate cyclase
MW290_RS04825	COG3039	Transposase
MW290_RS04835	COG3256	nitric oxide reductase
MW290_RS04840	COG1959	2 iron, 2 sulfur cluster binding
MW290_RS04845	COG2151	metal-sulfur cluster biosynthetic enzyme
MW290_RS04865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MW290_RS04880	COG3300	MHYT domain
MW290_RS04880	COG5001	Diguanylate cyclase
MW290_RS04900	COG0840	transmembrane signaling receptor activity
MW290_RS04915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW290_RS04940	COG2204	response regulator
MW290_RS04955	COG3609	addiction module antidote protein, CC2985 family
MW290_RS05035	COG3039	Transposase
MW290_RS05155	COG0181	hydroxymethylbilane synthase activity
MW290_RS05160	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MW290_RS05175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MW290_RS05180	COG1360	Flagellar Motor Protein
MW290_RS05190	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MW290_RS05225	COG1191	sigma factor activity
MW290_RS05235	COG1070	Carbohydrate kinase
MW290_RS05240	COG0545	Peptidyl-prolyl cis-trans isomerase
MW290_RS05245	COG0626	cystathionine gamma-synthase activity
MW290_RS05255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MW290_RS05265	COG2814	Major facilitator Superfamily
MW290_RS05270	COG2040	homocysteine
MW290_RS05280	COG0165	Argininosuccinate lyase
MW290_RS05285	COG3275	phosphorelay sensor kinase activity
MW290_RS05300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MW290_RS05305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MW290_RS05310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS05315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS05320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MW290_RS05345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MW290_RS05350	COG0583	DNA-binding transcription factor activity
MW290_RS05360	COG1309	transcriptional regulator
MW290_RS05370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MW290_RS05395	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MW290_RS05400	COG4969	Belongs to the N-Me-Phe pilin family
MW290_RS05410	COG0747	negative chemotaxis
MW290_RS05425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MW290_RS05430	COG0058	SHG alpha-glucan phosphorylase activity
MW290_RS05435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MW290_RS05440	COG0297	glycogen (starch) synthase activity
MW290_RS05450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MW290_RS05475	COG0729	surface antigen
MW290_RS05510	COG4948	Mandelate Racemase Muconate Lactonizing
MW290_RS05535	COG2814	Major facilitator Superfamily
MW290_RS05550	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS05575	COG2205	protein histidine kinase activity
MW290_RS05580	COG2188	Transcriptional regulator
MW290_RS05595	COG0402	S-adenosylhomocysteine deaminase activity
MW290_RS05605	COG0745	RESPONSE REGULATOR receiver
MW290_RS05610	COG2205	protein histidine kinase activity
MW290_RS05640	COG0596	Alpha beta hydrolase
MW290_RS05655	COG0840	transmembrane signaling receptor activity
MW290_RS05685	COG3852	Histidine kinase
MW290_RS05690	COG0745	RESPONSE REGULATOR receiver
MW290_RS05710	COG3706	GGDEF domain
MW290_RS05720	COG3447	MASE1 domain protein
MW290_RS05720	COG5001	Diguanylate cyclase
MW290_RS05720	COG5002	protein histidine kinase activity
MW290_RS05725	COG1178	ABC-type Fe3 transport system permease component
MW290_RS05730	COG3842	ATPase activity
MW290_RS05735	COG0793	Belongs to the peptidase S41A family
MW290_RS05740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MW290_RS05755	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MW290_RS05765	COG0010	Belongs to the arginase family
MW290_RS05810	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS05830	COG1201	RNA secondary structure unwinding
MW290_RS05845	COG3447	MASE1 domain protein
MW290_RS05845	COG5001	Diguanylate cyclase
MW290_RS05845	COG5002	protein histidine kinase activity
MW290_RS05855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS05870	COG2986	histidine ammonia-lyase
MW290_RS05875	COG2188	Transcriptional regulator
MW290_RS05890	COG0402	S-adenosylhomocysteine deaminase activity
MW290_RS05910	COG1505	serine-type exopeptidase activity
MW290_RS05920	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS05970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MW290_RS05975	COG0835	chemotaxis
MW290_RS05980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MW290_RS05985	COG1674	ftsk spoiiie
MW290_RS05990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MW290_RS05995	COG0492	ferredoxin-NADP+ reductase activity
MW290_RS06000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MW290_RS06005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MW290_RS06015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MW290_RS06015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MW290_RS06025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MW290_RS06030	COG0180	Tryptophanyl-tRNA synthetase
MW290_RS06040	COG0534	Mate efflux family protein
MW290_RS06075	COG1960	acyl-CoA dehydrogenase activity
MW290_RS06080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MW290_RS06085	COG1024	Enoyl-CoA hydratase
MW290_RS06090	COG4770	biotin carboxylase activity
MW290_RS06105	COG1024	Enoyl-CoA hydratase
MW290_RS06135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MW290_RS06140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MW290_RS06145	COG1047	Peptidyl-prolyl cis-trans
MW290_RS06150	COG2003	Belongs to the UPF0758 family
MW290_RS06160	COG2346	COG2346, Truncated hemoglobins
MW290_RS06175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MW290_RS06180	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MW290_RS06185	COG2201	protein-glutamate methylesterase activity
MW290_RS06195	COG0583	DNA-binding transcription factor activity
MW290_RS06200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MW290_RS06205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MW290_RS06210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MW290_RS06215	COG0631	protein serine/threonine phosphatase activity
MW290_RS06225	COG1561	YicC-like family, N-terminal region
MW290_RS06260	COG4178	(ABC) transporter
MW290_RS06290	COG0840	transmembrane signaling receptor activity
MW290_RS06320	COG3046	protein related to deoxyribodipyrimidine photolyase
MW290_RS06345	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
MW290_RS06350	COG0784	Response regulator, receiver
MW290_RS06350	COG4191	Histidine kinase
MW290_RS06355	COG0835	chemotaxis
MW290_RS06375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MW290_RS06385	COG3384	dioxygenase
MW290_RS06425	COG4603	Belongs to the binding-protein-dependent transport system permease family
MW290_RS06430	COG3845	ABC transporter
MW290_RS06435	COG2252	PERMEase
MW290_RS06440	COG0402	S-adenosylhomocysteine deaminase activity
MW290_RS06455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MW290_RS06460	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MW290_RS06460	COG3608	succinylglutamate desuccinylase aspartoacylase
MW290_RS06470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MW290_RS06475	COG2354	Protein conserved in bacteria
MW290_RS06485	COG0339	signal peptide processing
MW290_RS06495	COG0583	DNA-binding transcription factor activity
MW290_RS06520	COG1609	Transcriptional regulator
MW290_RS06535	COG3842	ATPase activity
MW290_RS06540	COG1653	transport
MW290_RS06545	COG1175	transmembrane transport
MW290_RS06560	COG0673	inositol 2-dehydrogenase activity
MW290_RS06570	COG0583	DNA-binding transcription factor activity
MW290_RS06575	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS06615	COG2764	glyoxalase bleomycin resistance protein dioxygenase
MW290_RS06625	COG1183	phosphatidylcholine synthase activity
MW290_RS06650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MW290_RS06670	COG4638	Rieske (2fe-2S)
MW290_RS06690	COG0154	amidase activity
MW290_RS06725	COG0583	DNA-binding transcription factor activity
MW290_RS06750	COG0191	fructose-bisphosphate aldolase activity
MW290_RS06755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MW290_RS06760	COG3954	Phosphoribulokinase
MW290_RS06765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MW290_RS06775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MW290_RS06785	COG0464	growth
MW290_RS06795	COG1850	ribulose-bisphosphate carboxylase activity
MW290_RS06830	COG0714	Associated with various cellular activities
MW290_RS06845	COG2197	response regulator
MW290_RS06885	COG2010	Cytochrome c
MW290_RS06970	COG0535	radical SAM domain protein
MW290_RS06985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MW290_RS06995	COG4585	Histidine kinase
MW290_RS07020	COG0840	transmembrane signaling receptor activity
MW290_RS07030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MW290_RS07030	COG0512	Glutamine amidotransferase of anthranilate synthase
MW290_RS07045	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
MW290_RS07050	COG1229	Formylmethanofuran dehydrogenase subunit A
MW290_RS07085	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
MW290_RS07095	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MW290_RS07100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MW290_RS07105	COG2264	protein methyltransferase activity
MW290_RS07110	COG1511	domain protein
MW290_RS07110	COG3264	Mechanosensitive ion channel
MW290_RS07115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MW290_RS07120	COG1910	domain protein
MW290_RS07125	COG0252	asparaginase activity
MW290_RS07135	COG0829	nickel cation binding
MW290_RS07140	COG0837	glucose binding
MW290_RS07180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MW290_RS07200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS07210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MW290_RS07245	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS07260	COG0673	inositol 2-dehydrogenase activity
MW290_RS07280	COG0784	Response regulator, receiver
MW290_RS07280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW290_RS07280	COG2198	Histidine kinase
MW290_RS07280	COG2205	protein histidine kinase activity
MW290_RS07285	COG2197	response regulator
MW290_RS07320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MW290_RS07325	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS07335	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS07345	COG1174	glycine betaine transport
MW290_RS07350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MW290_RS07355	COG1252	NADH dehydrogenase
MW290_RS07360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MW290_RS07375	COG1192	Involved in chromosome partitioning
MW290_RS07385	COG5002	protein histidine kinase activity
MW290_RS07385	COG2198	Histidine kinase
MW290_RS07385	COG0784	Response regulator, receiver
MW290_RS07390	COG2205	protein histidine kinase activity
MW290_RS07390	COG0784	Response regulator, receiver
MW290_RS07400	COG0784	Response regulator, receiver
MW290_RS07400	COG5002	protein histidine kinase activity
MW290_RS07415	COG0589	response to stress
MW290_RS07440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MW290_RS07445	COG0583	DNA-binding transcription factor activity
MW290_RS07455	COG1917	Cupin 2, conserved barrel domain protein
MW290_RS07455	COG2207	Transcriptional regulator
MW290_RS07460	COG4638	Rieske (2fe-2S)
MW290_RS07465	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
MW290_RS07470	COG2146	nitrite reductase [NAD(P)H] activity
MW290_RS07525	COG3473	Maleate cis-trans isomerase
MW290_RS07535	COG0179	Fumarylacetoacetate (FAA) hydrolase
MW290_RS07575	COG1233	COG1233 Phytoene dehydrogenase and related
MW290_RS07580	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MW290_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS07610	COG1609	Transcriptional regulator
MW290_RS07615	COG1595	DNA-templated transcription, initiation
MW290_RS07625	COG4774	siderophore transport
MW290_RS07630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW290_RS07650	COG2072	flavoprotein involved in K transport
MW290_RS07655	COG2207	Transcriptional regulator
MW290_RS07655	COG3708	Transcriptional regulator
MW290_RS07680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MW290_RS07690	COG4804	nuclease activity
MW290_RS07695	COG0765	amino acid transport
MW290_RS07700	COG0765	amino acid transport
MW290_RS07705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW290_RS07710	COG1126	abc transporter atp-binding protein
MW290_RS07720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MW290_RS07735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MW290_RS07740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW290_RS07740	COG2205	protein histidine kinase activity
MW290_RS07750	COG2204	response regulator
MW290_RS07755	COG5002	protein histidine kinase activity
MW290_RS07775	COG0514	ATP-dependent DNA helicase (RecQ)
MW290_RS07780	COG0028	Belongs to the TPP enzyme family
MW290_RS07795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MW290_RS07800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MW290_RS07800	COG2755	lipolytic protein G-D-S-L family
MW290_RS07820	COG1116	anion transmembrane transporter activity
MW290_RS07825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS07835	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MW290_RS07860	COG0179	Fumarylacetoacetate (FAA) hydrolase
MW290_RS07870	COG0583	DNA-binding transcription factor activity
MW290_RS07900	COG2188	Transcriptional regulator
MW290_RS07915	COG3383	formate dehydrogenase (NAD+) activity
MW290_RS07925	COG2154	pterin-4-alpha-carbinolamine dehydratase
MW290_RS07935	COG0702	epimerase
MW290_RS07945	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
MW290_RS07950	COG0189	ligase activity
MW290_RS07960	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
MW290_RS07970	COG3284	Transcriptional regulator
MW290_RS08000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MW290_RS08020	COG4453	Protein conserved in bacteria
MW290_RS08030	COG0745	RESPONSE REGULATOR receiver
MW290_RS08065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MW290_RS08120	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MW290_RS08125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MW290_RS08140	COG4251	negative regulation of phosphorylation
MW290_RS08145	COG0693	protein deglycase activity
MW290_RS08170	COG3039	Transposase
MW290_RS08195	COG0583	DNA-binding transcription factor activity
MW290_RS08200	COG1473	amidohydrolase
MW290_RS08235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MW290_RS08240	COG2366	antibiotic biosynthetic process
MW290_RS08300	COG0745	RESPONSE REGULATOR receiver
MW290_RS08305	COG2205	protein histidine kinase activity
MW290_RS08340	COG1136	(ABC) transporter
MW290_RS08355	COG0596	Alpha beta hydrolase
MW290_RS08360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MW290_RS08365	COG0583	DNA-binding transcription factor activity
MW290_RS08370	COG0583	DNA-binding transcription factor activity
MW290_RS08380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MW290_RS08385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MW290_RS08395	COG3386	PFAM SMP-30 Gluconolaconase
MW290_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS08420	COG2192	nodulation
MW290_RS08430	COG0297	glycogen (starch) synthase activity
MW290_RS08435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MW290_RS08460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS08485	COG3546	catalase activity
MW290_RS08490	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MW290_RS08495	COG2124	cytochrome p450
MW290_RS08500	COG0243	molybdopterin cofactor binding
MW290_RS08505	COG4628	conserved protein (DUF2132)
MW290_RS08510	COG2900	Belongs to the SlyX family
MW290_RS08565	COG0643	Histidine kinase
MW290_RS08565	COG2198	Histidine kinase
MW290_RS08570	COG0745	RESPONSE REGULATOR receiver
MW290_RS08620	COG1338	Plays a role in the flagellum-specific transport system
MW290_RS08630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MW290_RS08670	COG1766	The M ring may be actively involved in energy transduction
MW290_RS08675	COG1677	Flagellar hook-basal body complex protein FliE
MW290_RS08680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MW290_RS08700	COG0346	lactoylglutathione lyase activity
MW290_RS08710	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MW290_RS08715	COG1518	maintenance of DNA repeat elements
MW290_RS08720	COG1468	defense response to virus
MW290_RS08750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MW290_RS08755	COG1706	bacterial-type flagellum-dependent cell motility
MW290_RS08760	COG1705	Flagellar rod assembly protein muramidase FlgJ
MW290_RS08760	COG3951	Flagellar rod assembly protein muramidase FlgJ
MW290_RS08775	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MW290_RS08800	COG4251	negative regulation of phosphorylation
MW290_RS08835	COG1136	(ABC) transporter
MW290_RS08850	COG1121	(ABC) transporter
MW290_RS08870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MW290_RS08875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MW290_RS08890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MW290_RS08890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MW290_RS08915	COG2165	general secretion pathway protein
MW290_RS08925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MW290_RS08930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MW290_RS08935	COG0741	lytic transglycosylase activity
MW290_RS08940	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MW290_RS08955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MW290_RS08965	COG4771	TonB-dependent receptor
MW290_RS08970	COG0259	pyridoxamine-phosphate oxidase activity
MW290_RS08975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MW290_RS08990	COG0800	Aldolase
MW290_RS08995	COG0346	lactoylglutathione lyase activity
MW290_RS09010	COG2119	membrane
MW290_RS09015	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS09055	COG4993	Dehydrogenase
MW290_RS09060	COG0753	catalase activity
MW290_RS09070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MW290_RS09075	COG0583	DNA-binding transcription factor activity
MW290_RS09085	COG4948	Mandelate Racemase Muconate Lactonizing
MW290_RS09090	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS09095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MW290_RS09105	COG2197	response regulator
MW290_RS09110	COG2205	protein histidine kinase activity
MW290_RS09110	COG2202	Pas domain
MW290_RS09130	COG3706	GGDEF domain
MW290_RS09140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MW290_RS09145	COG0366	Alpha amylase catalytic
MW290_RS09150	COG0366	Alpha amylase catalytic
MW290_RS09215	COG1295	ribonuclease BN
MW290_RS09225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS09230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MW290_RS09235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS09260	COG0450	alkyl hydroperoxide reductase
MW290_RS09265	COG0625	glutathione transferase activity
MW290_RS09280	COG1045	serine acetyltransferase
MW290_RS09290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MW290_RS09295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MW290_RS09310	COG1464	Belongs to the NlpA lipoprotein family
MW290_RS09315	COG1116	anion transmembrane transporter activity
MW290_RS09320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS09325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS09330	COG1464	Belongs to the NlpA lipoprotein family
MW290_RS09335	COG2011	ABC-type metal ion transport system permease component
MW290_RS09360	COG1116	anion transmembrane transporter activity
MW290_RS09365	COG4521	taurine ABC transporter
MW290_RS09370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS09375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS09380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS09390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MW290_RS09405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS09420	COG0747	negative chemotaxis
MW290_RS09430	COG0584	glycerophosphoryl diester phosphodiesterase
MW290_RS09440	COG0121	glutamine amidotransferase
MW290_RS09470	COG1464	Belongs to the NlpA lipoprotein family
MW290_RS09475	COG4608	Belongs to the ABC transporter superfamily
MW290_RS09480	COG0444	Belongs to the ABC transporter superfamily
MW290_RS09485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MW290_RS09495	COG0747	negative chemotaxis
MW290_RS09520	COG1116	anion transmembrane transporter activity
MW290_RS09525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS09535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MW290_RS09555	COG1404	Belongs to the peptidase S8 family
MW290_RS09565	COG1595	DNA-templated transcription, initiation
MW290_RS09580	COG1858	cytochrome C peroxidase
MW290_RS09600	COG3284	Transcriptional regulator
MW290_RS09610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS09610	COG1116	anion transmembrane transporter activity
MW290_RS09615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS09650	COG0745	RESPONSE REGULATOR receiver
MW290_RS09660	COG3550	peptidyl-serine autophosphorylation
MW290_RS09670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MW290_RS09675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS09695	COG1253	flavin adenine dinucleotide binding
MW290_RS09705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS09710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS09715	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MW290_RS09720	COG3265	gluconokinase activity
MW290_RS09725	COG1609	Transcriptional regulator
MW290_RS09730	COG1595	DNA-templated transcription, initiation
MW290_RS09760	COG3483	tryptophan 2,3-dioxygenase activity
MW290_RS09765	COG0657	acetylesterase activity
MW290_RS09770	COG1063	alcohol dehydrogenase
MW290_RS09775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS09810	COG0840	transmembrane signaling receptor activity
MW290_RS09815	COG0683	leucine binding
MW290_RS09820	COG0436	Aminotransferase
MW290_RS09825	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MW290_RS09830	COG1185	polyribonucleotide nucleotidyltransferase activity
MW290_RS09835	COG3321	synthase
MW290_RS09835	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS09835	COG0604	alcohol dehydrogenase
MW290_RS09840	COG0149	triose-phosphate isomerase activity
MW290_RS09855	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MW290_RS09860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MW290_RS09865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MW290_RS09870	COG0649	NAD binding
MW290_RS09875	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MW290_RS09880	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MW290_RS09885	COG1034	ATP synthesis coupled electron transport
MW290_RS09890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MW290_RS09895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MW290_RS09905	COG0713	ATP synthesis coupled electron transport
MW290_RS09920	COG1007	ATP synthesis coupled electron transport
MW290_RS09930	COG0494	nUDIX hydrolase
MW290_RS09960	COG1706	bacterial-type flagellum-dependent cell motility
MW290_RS09970	COG4786	Flagellar basal body rod
MW290_RS09985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MW290_RS09990	COG1558	bacterial-type flagellum-dependent cell motility
MW290_RS10000	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
MW290_RS10005	COG3951	Flagellar rod assembly protein muramidase FlgJ
MW290_RS10005	COG1705	Flagellar rod assembly protein muramidase FlgJ
MW290_RS10020	COG1360	Flagellar Motor Protein
MW290_RS10025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MW290_RS10030	COG1191	sigma factor activity
MW290_RS10075	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MW290_RS10095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MW290_RS10105	COG1987	bacterial-type flagellum assembly
MW290_RS10115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MW290_RS10135	COG3039	Transposase
MW290_RS10190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MW290_RS10195	COG1819	glycosyl
MW290_RS10275	COG4221	oxidoreductase activity
MW290_RS10290	COG1131	(ABC) transporter
MW290_RS10310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MW290_RS10315	COG2828	Protein conserved in bacteria
MW290_RS10325	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
MW290_RS10350	COG1086	Polysaccharide biosynthesis protein
MW290_RS10355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MW290_RS10360	COG1083	cytidylyl-transferase
MW290_RS10385	COG2089	acid synthase
MW290_RS10400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MW290_RS10410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MW290_RS10420	COG1280	lysine exporter protein (LysE YggA)
MW290_RS10425	COG0277	FAD linked oxidase domain protein
MW290_RS10435	COG1295	ribonuclease BN
MW290_RS10450	COG2267	carboxylic ester hydrolase activity
MW290_RS10465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MW290_RS10510	COG0583	DNA-binding transcription factor activity
MW290_RS10580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MW290_RS10585	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MW290_RS10590	COG2080	2 iron, 2 sulfur cluster binding
MW290_RS10600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MW290_RS10610	COG1473	amidohydrolase
MW290_RS10620	COG0071	Belongs to the small heat shock protein (HSP20) family
MW290_RS10665	COG1191	sigma factor activity
MW290_RS10685	COG0210	DNA helicase
MW290_RS10695	COG5001	Diguanylate cyclase
MW290_RS10715	COG0625	glutathione transferase activity
MW290_RS10770	COG4941	Belongs to the sigma-70 factor family
MW290_RS10785	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MW290_RS10795	COG2423	ornithine cyclodeaminase activity
MW290_RS10815	COG0840	transmembrane signaling receptor activity
MW290_RS10820	COG1953	Uracil, thiamine, allantoin
MW290_RS10845	COG0392	lysyltransferase activity
MW290_RS10860	COG1125	glycine betaine transport
MW290_RS10860	COG0517	IMP dehydrogenase activity
MW290_RS10875	COG0640	Transcriptional regulator
MW290_RS10880	COG0861	Integral membrane protein TerC family
MW290_RS10895	COG4191	Histidine kinase
MW290_RS10895	COG0784	Response regulator, receiver
MW290_RS10930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS10935	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MW290_RS10940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MW290_RS10945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS10950	COG1414	Transcriptional regulator
MW290_RS10970	COG0596	Alpha beta hydrolase
MW290_RS10975	COG5001	Diguanylate cyclase
MW290_RS10975	COG5002	protein histidine kinase activity
MW290_RS11000	COG1609	Transcriptional regulator
MW290_RS11005	COG1172	Belongs to the binding-protein-dependent transport system permease family
MW290_RS11015	COG1129	ABC transporter
MW290_RS11020	COG1172	Belongs to the binding-protein-dependent transport system permease family
MW290_RS11025	COG2376	Dihydroxyacetone kinase
MW290_RS11030	COG1461	Dihydroxyacetone kinase
MW290_RS11080	COG1744	ABC transporter substrate-binding protein PnrA-like
MW290_RS11090	COG0494	nUDIX hydrolase
MW290_RS11100	COG0583	DNA-binding transcription factor activity
MW290_RS11120	COG2198	Histidine kinase
MW290_RS11120	COG5002	protein histidine kinase activity
MW290_RS11120	COG0784	Response regulator, receiver
MW290_RS11130	COG3734	2-keto-3-deoxy-galactonokinase
MW290_RS11135	COG0800	Aldolase
MW290_RS11140	COG0477	Major facilitator Superfamily
MW290_RS11150	COG1672	PFAM Archaeal ATPase
MW290_RS11150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MW290_RS11155	COG3179	chitinase
MW290_RS11165	COG0693	protein deglycase activity
MW290_RS11190	COG1609	Transcriptional regulator
MW290_RS11195	COG1414	Transcriptional regulator
MW290_RS11200	COG0477	Major facilitator Superfamily
MW290_RS11205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MW290_RS11220	COG3246	L-lysine catabolic process to acetate
MW290_RS11225	COG0702	epimerase
MW290_RS11235	COG1196	nuclear chromosome segregation
MW290_RS11280	COG2733	membrane
MW290_RS11285	COG2207	Transcriptional regulator
MW290_RS11290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MW290_RS11295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MW290_RS11300	COG0842	Transport permease protein
MW290_RS11305	COG1131	(ABC) transporter
MW290_RS11310	COG0586	Pfam SNARE associated Golgi protein
MW290_RS11360	COG2808	Putative FMN-binding domain
MW290_RS11370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MW290_RS11375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MW290_RS11445	COG3210	domain, Protein
MW290_RS11450	COG2831	hemolysin activation secretion protein
MW290_RS11475	COG1404	Belongs to the peptidase S8 family
MW290_RS11490	COG0251	oxidation-reduction process
MW290_RS11525	COG0840	transmembrane signaling receptor activity
MW290_RS11545	COG0583	DNA-binding transcription factor activity
MW290_RS11600	COG0745	RESPONSE REGULATOR receiver
MW290_RS11605	COG0642	Histidine kinase
MW290_RS11615	COG4221	oxidoreductase activity
MW290_RS11625	COG1022	Amp-dependent synthetase and ligase
MW290_RS11645	COG3733	amine oxidase
MW290_RS11655	COG3851	Histidine kinase
MW290_RS11685	COG1414	Transcriptional regulator
MW290_RS11690	COG3842	ATPase activity
MW290_RS11695	COG1176	ABC-type spermidine putrescine transport system, permease component I
MW290_RS11700	COG1177	transmembrane transport
MW290_RS11715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS11730	COG5383	Protein conserved in bacteria
MW290_RS11735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW290_RS11765	COG1228	amidohydrolase
MW290_RS11775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS11780	COG0129	dihydroxy-acid dehydratase activity
MW290_RS11790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MW290_RS11795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS11810	COG2205	protein histidine kinase activity
MW290_RS11810	COG2198	Histidine kinase
MW290_RS11810	COG0784	Response regulator, receiver
MW290_RS11835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MW290_RS11850	COG1215	transferase activity, transferring glycosyl groups
MW290_RS11890	COG3118	belongs to the thioredoxin family
MW290_RS11900	COG0840	transmembrane signaling receptor activity
MW290_RS11950	COG3300	MHYT domain
MW290_RS11950	COG5001	Diguanylate cyclase
MW290_RS11965	COG0625	glutathione transferase activity
MW290_RS11990	COG1024	Enoyl-CoA hydratase
MW290_RS12060	COG4397	Mu-like prophage major head subunit gpT
MW290_RS12085	COG4383	Mu-like prophage protein gp29
MW290_RS12090	COG4373	Mu-like prophage FluMu protein gp28
MW290_RS12110	COG0582	viral genome integration into host DNA
MW290_RS12180	COG0436	Aminotransferase
MW290_RS12185	COG0583	DNA-binding transcription factor activity
MW290_RS12200	COG0795	lipopolysaccharide-transporting ATPase activity
MW290_RS12205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MW290_RS12225	COG4651	solute:proton antiporter activity
MW290_RS12225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MW290_RS12235	COG0513	Belongs to the DEAD box helicase family
MW290_RS12260	COG0183	Belongs to the thiolase family
MW290_RS12270	COG2175	clavaminate synthase activity
MW290_RS12295	COG3622	Belongs to the hyi family
MW290_RS12305	COG0235	Class ii aldolase
MW290_RS12310	COG3395	kinase activity
MW290_RS12315	COG2084	Dehydrogenase
MW290_RS12320	COG2610	gluconate transmembrane transporter activity
MW290_RS12325	COG2186	Transcriptional regulator
MW290_RS12335	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS12355	COG4654	Cytochrome c, class I
MW290_RS12390	COG1797	cobyrinic acid a,c-diamide synthase activity
MW290_RS12415	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
MW290_RS12445	COG3411	Ferredoxin
MW290_RS12450	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
MW290_RS12460	COG3609	addiction module antidote protein, CC2985 family
MW290_RS12490	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MW290_RS12495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW290_RS12500	COG0765	amino acid transport
MW290_RS12510	COG0840	transmembrane signaling receptor activity
MW290_RS12515	COG0438	transferase activity, transferring glycosyl groups
MW290_RS12545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MW290_RS12550	COG1595	DNA-templated transcription, initiation
MW290_RS12560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS12570	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS12575	COG0154	amidase activity
MW290_RS12715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MW290_RS12735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MW290_RS12740	COG2072	flavoprotein involved in K transport
MW290_RS12755	COG2144	transferase activity, transferring acyl groups
MW290_RS12780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW290_RS12785	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MW290_RS12795	COG4558	Periplasmic binding protein
MW290_RS12815	COG1629	transport
MW290_RS12865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MW290_RS12870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS12875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS12965	COG1737	Transcriptional regulator
MW290_RS12965	COG0837	glucose binding
MW290_RS12970	COG0366	Alpha amylase catalytic
MW290_RS12975	COG3833	ABC-type maltose transport systems, permease component
MW290_RS12980	COG1175	transmembrane transport
MW290_RS12990	COG3842	ATPase activity
MW290_RS12995	COG0366	Alpha amylase catalytic
MW290_RS13015	COG0779	Required for maturation of 30S ribosomal subunits
MW290_RS13020	COG2251	uridine kinase activity
MW290_RS13020	COG0195	Participates in both transcription termination and antitermination
MW290_RS13025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MW290_RS13030	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MW290_RS13035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MW290_RS13040	COG1217	gtp-binding protein TYPA
MW290_RS13055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MW290_RS13060	COG1752	Esterase of the alpha-beta hydrolase superfamily
MW290_RS13085	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS13095	COG1177	transmembrane transport
MW290_RS13100	COG1176	ABC-type spermidine putrescine transport system, permease component I
MW290_RS13105	COG3842	ATPase activity
MW290_RS13125	COG0174	glutamine synthetase
MW290_RS13130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MW290_RS13135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS13140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MW290_RS13145	COG1522	sequence-specific DNA binding
MW290_RS13150	COG0512	Glutamine amidotransferase of anthranilate synthase
MW290_RS13150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MW290_RS13155	COG2224	Isocitrate lyase
MW290_RS13160	COG0657	acetylesterase activity
MW290_RS13185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MW290_RS13190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MW290_RS13205	COG0084	hydrolase, TatD family'
MW290_RS13240	COG2205	protein histidine kinase activity
MW290_RS13245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MW290_RS13250	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MW290_RS13255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MW290_RS13280	COG3447	MASE1 domain protein
MW290_RS13280	COG5001	Diguanylate cyclase
MW290_RS13280	COG5002	protein histidine kinase activity
MW290_RS13285	COG1960	acyl-CoA dehydrogenase activity
MW290_RS13290	COG0583	DNA-binding transcription factor activity
MW290_RS13320	COG3710	Transcriptional regulator
MW290_RS13340	COG1506	peptidase
MW290_RS13340	COG0823	Involved in the tonB-independent uptake of proteins
MW290_RS13365	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MW290_RS13380	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MW290_RS13385	COG1845	cytochrome c oxidase, subunit III
MW290_RS13390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MW290_RS13395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MW290_RS13400	COG0477	Major facilitator Superfamily
MW290_RS13405	COG0488	(ABC) transporter
MW290_RS13410	COG0513	Belongs to the DEAD box helicase family
MW290_RS13425	COG3022	response to hydroperoxide
MW290_RS13445	COG0784	Response regulator, receiver
MW290_RS13445	COG2205	protein histidine kinase activity
MW290_RS13460	COG0642	Histidine kinase
MW290_RS13470	COG1162	GTPase activity
MW290_RS13495	COG1846	Transcriptional regulator
MW290_RS13505	COG4191	Histidine kinase
MW290_RS13515	COG1301	dicarboxylic acid transport
MW290_RS13520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MW290_RS13560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MW290_RS13585	COG0747	negative chemotaxis
MW290_RS13590	COG4172	Belongs to the ABC transporter superfamily
MW290_RS13595	COG1446	asparaginase
MW290_RS13620	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS13630	COG2207	Transcriptional regulator
MW290_RS13640	COG0246	Mannitol dehydrogenase
MW290_RS13645	COG3842	ATPase activity
MW290_RS13650	COG0395	ABC-type sugar transport system, permease component
MW290_RS13655	COG1175	transmembrane transport
MW290_RS13670	COG2197	response regulator
MW290_RS13685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MW290_RS13685	COG2146	nitrite reductase [NAD(P)H] activity
MW290_RS13690	COG3707	response regulator
MW290_RS13695	COG2116	formate transmembrane transporter activity
MW290_RS13700	COG0515	serine threonine protein kinase
MW290_RS13700	COG2815	serine threonine protein kinase
MW290_RS13710	COG0784	Response regulator, receiver
MW290_RS13710	COG4191	Histidine kinase
MW290_RS13715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MW290_RS13750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MW290_RS13760	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS13765	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS13775	COG0596	Alpha beta hydrolase
MW290_RS13795	COG0363	glucosamine-6-phosphate deaminase activity
MW290_RS13805	COG2080	2 iron, 2 sulfur cluster binding
MW290_RS13810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MW290_RS13815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MW290_RS13820	COG0840	transmembrane signaling receptor activity
MW290_RS13835	COG2885	chlorophyll binding
MW290_RS13845	COG3920	Histidine kinase
MW290_RS13855	COG2375	cellular response to nickel ion
MW290_RS13865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MW290_RS13895	COG2159	amidohydrolase
MW290_RS13900	COG0583	DNA-binding transcription factor activity
MW290_RS13915	COG0840	transmembrane signaling receptor activity
MW290_RS13930	COG3384	dioxygenase
MW290_RS13945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS13950	COG0583	DNA-binding transcription factor activity
MW290_RS13955	COG0492	ferredoxin-NADP+ reductase activity
MW290_RS13960	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS13965	COG1024	Enoyl-CoA hydratase
MW290_RS13975	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS13985	COG2951	lytic endotransglycosylase activity
MW290_RS14030	COG1228	amidohydrolase
MW290_RS14045	COG1522	sequence-specific DNA binding
MW290_RS14070	COG0745	RESPONSE REGULATOR receiver
MW290_RS14075	COG2205	protein histidine kinase activity
MW290_RS14140	COG3437	response regulator, receiver
MW290_RS14155	COG5001	Diguanylate cyclase
MW290_RS14155	COG4251	negative regulation of phosphorylation
MW290_RS14155	COG3706	GGDEF domain
MW290_RS14155	COG2203	Gaf domain
MW290_RS14170	COG2017	converts alpha-aldose to the beta-anomer
MW290_RS14175	COG3386	PFAM SMP-30 Gluconolaconase
MW290_RS14190	COG1879	ABC-type sugar transport system periplasmic component
MW290_RS14195	COG1129	ABC transporter
MW290_RS14200	COG1172	Belongs to the binding-protein-dependent transport system permease family
MW290_RS14205	COG1172	Belongs to the binding-protein-dependent transport system permease family
MW290_RS14220	COG4948	Mandelate Racemase Muconate Lactonizing
MW290_RS14255	COG2433	Pfam Transposase IS66
MW290_RS14260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MW290_RS14275	COG3177	Filamentation induced by cAMP protein fic
MW290_RS14285	COG0602	queuosine metabolic process
MW290_RS14290	COG0720	synthase
MW290_RS14320	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
MW290_RS14325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MW290_RS14335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MW290_RS14345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MW290_RS14360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS14390	COG1073	alpha beta
MW290_RS14410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS14415	COG2814	Major facilitator Superfamily
MW290_RS14425	COG4221	oxidoreductase activity
MW290_RS14430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MW290_RS14445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MW290_RS14455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MW290_RS14465	COG0745	RESPONSE REGULATOR receiver
MW290_RS14470	COG2205	protein histidine kinase activity
MW290_RS14495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MW290_RS14495	COG0543	2 iron, 2 sulfur cluster binding
MW290_RS14535	COG3795	YCII-related domain
MW290_RS14540	COG4941	Belongs to the sigma-70 factor family
MW290_RS14550	COG1573	uracil-dna glycosylase
MW290_RS14565	COG0489	protein tyrosine kinase activity
MW290_RS14575	COG3409	Peptidoglycan-binding domain 1 protein
MW290_RS14575	COG3267	Type II secretory pathway component ExeA
MW290_RS14620	COG0367	asparagine synthase
MW290_RS14635	COG0438	transferase activity, transferring glycosyl groups
MW290_RS14655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MW290_RS14670	COG1215	transferase activity, transferring glycosyl groups
MW290_RS14715	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS14735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MW290_RS14740	COG1902	pentaerythritol trinitrate reductase activity
MW290_RS14745	COG3180	Ammonia monooxygenase
MW290_RS14750	COG2258	MOSC domain
MW290_RS14755	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MW290_RS14780	COG1595	DNA-templated transcription, initiation
MW290_RS14825	COG1280	lysine exporter protein (LysE YggA)
MW290_RS14835	COG1607	acyl-coa hydrolase
MW290_RS14845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MW290_RS14865	COG0386	Belongs to the glutathione peroxidase family
MW290_RS14870	COG1448	Aminotransferase
MW290_RS14895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MW290_RS14905	COG0444	Belongs to the ABC transporter superfamily
MW290_RS14910	COG4608	Belongs to the ABC transporter superfamily
MW290_RS14915	COG0747	negative chemotaxis
MW290_RS14920	COG0154	amidase activity
MW290_RS14935	COG0625	glutathione transferase activity
MW290_RS14945	COG2132	Multicopper oxidase
MW290_RS14965	COG2203	Gaf domain
MW290_RS14965	COG2200	EAL domain
MW290_RS14965	COG2199	diguanylate cyclase activity
MW290_RS14970	COG1653	transport
MW290_RS15000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MW290_RS15035	COG0583	DNA-binding transcription factor activity
MW290_RS15040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS15055	COG0653	protein targeting
MW290_RS15075	COG1279	arginine transmembrane transporter activity
MW290_RS15080	COG0443	Heat shock 70 kDa protein
MW290_RS15095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS15110	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS15115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MW290_RS15140	COG0484	heat shock protein binding
MW290_RS15155	COG0514	ATP-dependent DNA helicase (RecQ)
MW290_RS15175	COG2205	protein histidine kinase activity
MW290_RS15175	COG0784	Response regulator, receiver
MW290_RS15190	COG3128	pkhd-type hydroxylase
MW290_RS15195	COG4774	siderophore transport
MW290_RS15215	COG1950	PFAM Membrane protein of
MW290_RS15220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MW290_RS15230	COG4783	chaperone-mediated protein folding
MW290_RS15235	COG0315	cyclic pyranopterin monophosphate synthase activity
MW290_RS15240	COG3307	-O-antigen
MW290_RS15255	COG1234	tRNA 3'-trailer cleavage
MW290_RS15270	COG0631	protein serine/threonine phosphatase activity
MW290_RS15280	COG0861	Integral membrane protein TerC family
MW290_RS15285	COG0861	Integral membrane protein TerC family
MW290_RS15290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MW290_RS15295	COG0045	succinate-CoA ligase (ADP-forming) activity
MW290_RS15300	COG2137	regulation of response to DNA damage stimulus
MW290_RS15305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MW290_RS15315	COG0642	Histidine kinase
MW290_RS15320	COG0772	Belongs to the SEDS family
MW290_RS15325	COG0768	penicillin binding
MW290_RS15335	COG1792	Involved in formation and maintenance of cell shape
MW290_RS15340	COG1077	Cell shape determining protein MreB Mrl
MW290_RS15345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MW290_RS15350	COG0154	amidase activity
MW290_RS15355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MW290_RS15365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MW290_RS15385	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MW290_RS15400	COG2223	nitrite transmembrane transporter activity
MW290_RS15420	COG4166	transmembrane transport
MW290_RS15435	COG0601	transmembrane transport
MW290_RS15445	COG4172	Belongs to the ABC transporter superfamily
MW290_RS15465	COG0284	orotidine-5'-phosphate decarboxylase activity
MW290_RS15480	COG4269	membrane
MW290_RS15490	COG3845	ABC transporter
MW290_RS15495	COG4603	Belongs to the binding-protein-dependent transport system permease family
MW290_RS15500	COG1079	Belongs to the binding-protein-dependent transport system permease family
MW290_RS15515	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS15525	COG3851	Histidine kinase
MW290_RS15535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS15540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS15545	COG1116	anion transmembrane transporter activity
MW290_RS15545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS15550	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MW290_RS15560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MW290_RS15565	COG0402	S-adenosylhomocysteine deaminase activity
MW290_RS15570	COG0625	glutathione transferase activity
MW290_RS15575	COG0069	glutamate synthase activity
MW290_RS15580	COG0625	glutathione transferase activity
MW290_RS15585	COG2814	Major facilitator Superfamily
MW290_RS15590	COG0789	Transcriptional regulator
MW290_RS15595	COG2217	Heavy metal translocating P-type atpase
MW290_RS15625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MW290_RS15630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MW290_RS15630	COG2813	Specifically methylates the guanine in position
MW290_RS15635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MW290_RS15640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MW290_RS15645	COG3047	cAMP biosynthetic process
MW290_RS15655	COG3284	Transcriptional regulator
MW290_RS15665	COG0628	permease
MW290_RS15670	COG0625	glutathione transferase activity
MW290_RS15695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MW290_RS15715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MW290_RS15735	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MW290_RS15750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MW290_RS15755	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MW290_RS15760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MW290_RS15765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MW290_RS15770	COG1404	Belongs to the peptidase S8 family
MW290_RS15780	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MW290_RS15780	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MW290_RS15815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MW290_RS15845	COG0583	DNA-binding transcription factor activity
MW290_RS15850	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MW290_RS15860	COG0850	regulation of cytokinetic process
MW290_RS15865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MW290_RS15885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MW290_RS15895	COG5000	phosphorelay sensor kinase activity
MW290_RS15900	COG2204	response regulator
MW290_RS15930	COG0189	ligase activity
MW290_RS15930	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MW290_RS15935	COG0189	ligase activity
MW290_RS15935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MW290_RS15940	COG1132	(ABC) transporter
MW290_RS15950	COG0326	Molecular chaperone. Has ATPase activity
MW290_RS15955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MW290_RS15970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MW290_RS15975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MW290_RS15980	COG0316	Belongs to the HesB IscA family
MW290_RS15985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MW290_RS15990	COG0739	heme binding
MW290_RS15995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MW290_RS16000	COG1490	D-aminoacyl-tRNA deacylase activity
MW290_RS16010	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS16025	COG1522	sequence-specific DNA binding
MW290_RS16050	COG0656	L-ascorbic acid biosynthetic process
MW290_RS16055	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MW290_RS16080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MW290_RS16085	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MW290_RS16120	COG0583	DNA-binding transcription factor activity
MW290_RS16125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW290_RS16130	COG0765	amino acid transport
MW290_RS16135	COG0765	amino acid transport
MW290_RS16140	COG1126	abc transporter atp-binding protein
MW290_RS16145	COG0418	dihydroorotase activity
MW290_RS16165	COG2814	Major facilitator Superfamily
MW290_RS16170	COG5002	protein histidine kinase activity
MW290_RS16170	COG2205	protein histidine kinase activity
MW290_RS16170	COG0784	Response regulator, receiver
MW290_RS16195	COG1473	amidohydrolase
MW290_RS16200	COG0243	molybdopterin cofactor binding
MW290_RS16220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MW290_RS16225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MW290_RS16240	COG2010	Cytochrome c
MW290_RS16240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MW290_RS16245	COG2080	2 iron, 2 sulfur cluster binding
MW290_RS16250	COG1335	isochorismatase
MW290_RS16270	COG0683	leucine binding
MW290_RS16300	COG1309	transcriptional regulator
MW290_RS16320	COG1131	(ABC) transporter
MW290_RS16325	COG0842	Transport permease protein
MW290_RS16340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MW290_RS16345	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MW290_RS16350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MW290_RS16365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MW290_RS16370	COG0131	Imidazoleglycerol-phosphate dehydratase
MW290_RS16380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MW290_RS16385	COG0107	imidazoleglycerol-phosphate synthase activity
MW290_RS16390	COG0742	ribosomal rna small subunit methyltransferase
MW290_RS16395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MW290_RS16400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MW290_RS16410	COG0193	aminoacyl-tRNA hydrolase activity
MW290_RS16415	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MW290_RS16420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MW290_RS16430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MW290_RS16445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MW290_RS16465	COG1660	Displays ATPase and GTPase activities
MW290_RS16475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MW290_RS16480	COG1420	regulation of RNA biosynthetic process
MW290_RS16520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MW290_RS16525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MW290_RS16595	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS16600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MW290_RS16630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW290_RS16650	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MW290_RS16655	COG3706	GGDEF domain
MW290_RS16720	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MW290_RS16725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MW290_RS16730	COG1765	OsmC-like protein
MW290_RS16735	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MW290_RS16755	COG0601	transmembrane transport
MW290_RS16760	COG0747	negative chemotaxis
MW290_RS16765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MW290_RS16775	COG4608	Belongs to the ABC transporter superfamily
MW290_RS16790	COG1965	Belongs to the frataxin family
MW290_RS16830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MW290_RS16840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MW290_RS16850	COG0067	glutamate synthase
MW290_RS16850	COG0069	glutamate synthase activity
MW290_RS16850	COG0070	glutamate synthase
MW290_RS16860	COG1127	ABC transporter
MW290_RS16865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MW290_RS16870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MW290_RS16895	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MW290_RS16900	COG1840	ABC-type Fe3 transport system, periplasmic component
MW290_RS16915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MW290_RS16920	COG0166	Belongs to the GPI family
MW290_RS16950	COG5002	protein histidine kinase activity
MW290_RS16985	COG0789	Transcriptional regulator
MW290_RS16995	COG0288	reversible hydration of carbon dioxide
MW290_RS17000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MW290_RS17005	COG0183	Belongs to the thiolase family
MW290_RS17015	COG1960	acyl-CoA dehydrogenase activity
MW290_RS17055	COG3045	CreA protein
MW290_RS17085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MW290_RS17105	COG4221	oxidoreductase activity
MW290_RS17110	COG0583	DNA-binding transcription factor activity
MW290_RS17115	COG3485	protocatechuate 3,4-dioxygenase
MW290_RS17120	COG3485	protocatechuate 3,4-dioxygenase
MW290_RS17165	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS17180	COG1802	Transcriptional regulator
MW290_RS17185	COG2205	protein histidine kinase activity
MW290_RS17185	COG3850	Histidine kinase
MW290_RS17185	COG4999	Histidine kinase
MW290_RS17185	COG3437	response regulator, receiver
MW290_RS17190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MW290_RS17200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MW290_RS17205	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MW290_RS17210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MW290_RS17215	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MW290_RS17220	COG1333	cytochrome c biogenesis protein
MW290_RS17230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MW290_RS17240	COG0459	protein refolding
MW290_RS17245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MW290_RS17275	COG3604	Transcriptional regulator
MW290_RS17285	COG1733	regulation of RNA biosynthetic process
MW290_RS17305	COG3228	Belongs to the MtfA family
MW290_RS17355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MW290_RS17385	COG2721	sulfolactate sulfo-lyase activity
MW290_RS17395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MW290_RS17400	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS17405	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MW290_RS17415	COG0583	DNA-binding transcription factor activity
MW290_RS17425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MW290_RS17430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MW290_RS17440	COG0066	3-isopropylmalate dehydratase activity
MW290_RS17445	COG2080	2 iron, 2 sulfur cluster binding
MW290_RS17450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MW290_RS17450	COG2010	Cytochrome c
MW290_RS17465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS17475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS17485	COG2186	Transcriptional regulator
MW290_RS17490	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS17500	COG2084	Dehydrogenase
MW290_RS17525	COG0613	PHP domain protein
MW290_RS17530	COG2133	pyrroloquinoline quinone binding
MW290_RS17535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MW290_RS17550	COG1136	(ABC) transporter
MW290_RS17560	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MW290_RS17575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS17595	COG0425	Belongs to the sulfur carrier protein TusA family
MW290_RS17610	COG0525	valine-tRNA ligase activity
MW290_RS17615	COG0516	GMP reductase activity
MW290_RS17620	COG2814	Major facilitator Superfamily
MW290_RS17635	COG0210	DNA helicase
MW290_RS17660	COG0154	amidase activity
MW290_RS17675	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MW290_RS17685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MW290_RS17685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MW290_RS17705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MW290_RS17715	COG0248	Ppx GppA phosphatase
MW290_RS17745	COG1722	exodeoxyribonuclease VII activity
MW290_RS17750	COG0142	geranyltranstransferase activity
MW290_RS17755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MW290_RS17770	COG3177	Filamentation induced by cAMP protein fic
MW290_RS17785	COG0840	transmembrane signaling receptor activity
MW290_RS17815	COG0583	DNA-binding transcription factor activity
MW290_RS17820	COG0840	transmembrane signaling receptor activity
MW290_RS17825	COG1620	l-lactate permease
MW290_RS17830	COG1304	FMN binding
MW290_RS17835	COG0277	FAD linked oxidase domain protein
MW290_RS17840	COG0277	FAD linked oxidase domain protein
MW290_RS17845	COG0247	lactate metabolic process
MW290_RS17870	COG0784	Response regulator, receiver
MW290_RS17870	COG2198	Histidine kinase
MW290_RS17870	COG2205	protein histidine kinase activity
MW290_RS17900	COG0659	secondary active sulfate transmembrane transporter activity
MW290_RS17910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MW290_RS17910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MW290_RS17920	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MW290_RS17925	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MW290_RS17930	COG0489	protein tyrosine kinase activity
MW290_RS17935	COG1404	Belongs to the peptidase S8 family
MW290_RS17960	COG0717	Belongs to the dCTP deaminase family
MW290_RS17965	COG2321	neutral zinc metallopeptidase
MW290_RS17995	COG1558	bacterial-type flagellum-dependent cell motility
MW290_RS18000	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MW290_RS18020	COG1666	GTP binding
MW290_RS18025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MW290_RS18045	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS18050	COG0564	pseudouridine synthase activity
MW290_RS18060	COG4771	TonB-dependent receptor
MW290_RS18100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW290_RS18120	COG1597	lipid kinase activity
MW290_RS18135	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MW290_RS18155	COG1132	(ABC) transporter
MW290_RS18165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MW290_RS18180	COG1752	Esterase of the alpha-beta hydrolase superfamily
MW290_RS18190	COG3275	phosphorelay sensor kinase activity
MW290_RS18205	COG0433	COG0433 Predicted ATPase
MW290_RS18215	COG0217	transcriptional regulatory protein
MW290_RS18220	COG0151	Belongs to the GarS family
MW290_RS18225	COG0408	coproporphyrinogen oxidase activity
MW290_RS18230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MW290_RS18235	COG0799	negative regulation of ribosome biogenesis
MW290_RS18240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MW290_RS18245	COG0424	maF-like protein
MW290_RS18280	COG0625	glutathione transferase activity
MW290_RS18295	COG1132	(ABC) transporter
MW290_RS18300	COG0823	Involved in the tonB-independent uptake of proteins
MW290_RS18315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MW290_RS18355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MW290_RS18360	COG0277	FAD linked oxidase domain protein
MW290_RS18375	COG1393	Belongs to the ArsC family
MW290_RS18385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MW290_RS18390	COG1793	dna ligase
MW290_RS18400	COG2925	Exonuclease
MW290_RS18440	COG0039	L-malate dehydrogenase activity
MW290_RS18455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MW290_RS18460	COG1053	succinate dehydrogenase
MW290_RS18465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MW290_RS18470	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MW290_RS18475	COG0372	Belongs to the citrate synthase family
MW290_RS18490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MW290_RS18495	COG0066	3-isopropylmalate dehydratase activity
MW290_RS18500	COG0473	3-isopropylmalate dehydrogenase activity
MW290_RS18505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MW290_RS18515	COG0101	tRNA pseudouridine synthase activity
MW290_RS18520	COG0135	phosphoribosylanthranilate isomerase activity
MW290_RS18525	COG0133	tryptophan synthase activity
MW290_RS18530	COG0159	tryptophan synthase activity
MW290_RS18535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MW290_RS18540	COG0285	dihydrofolate synthase activity
MW290_RS18560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MW290_RS18595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MW290_RS18600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MW290_RS18620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MW290_RS18625	COG2855	membrane
MW290_RS18630	COG2188	Transcriptional regulator
MW290_RS18635	COG2721	sulfolactate sulfo-lyase activity
MW290_RS18640	COG2721	sulfolactate sulfo-lyase activity
MW290_RS18645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MW290_RS18650	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MW290_RS18660	COG0697	spore germination
MW290_RS18765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MW290_RS18770	COG1309	transcriptional regulator
MW290_RS18780	COG1968	undecaprenyl-diphosphatase activity
MW290_RS18785	COG0625	glutathione transferase activity
MW290_RS18790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MW290_RS18795	COG0589	response to stress
MW290_RS18800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS18820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS18825	COG0583	DNA-binding transcription factor activity
MW290_RS18865	COG0484	heat shock protein binding
MW290_RS18915	COG4197	protein conserved in bacteria, prophage-related
MW290_RS18960	COG4381	Mu-like prophage protein gp46
MW290_RS18995	COG2369	cell adhesion
MW290_RS19005	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MW290_RS19040	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS19055	COG1176	ABC-type spermidine putrescine transport system, permease component I
MW290_RS19065	COG3842	ATPase activity
MW290_RS19070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MW290_RS19075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW290_RS19080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MW290_RS19085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MW290_RS19090	COG0756	dUTP diphosphatase activity
MW290_RS19100	COG2850	peptidyl-arginine hydroxylation
MW290_RS19145	COG2199	diguanylate cyclase activity
MW290_RS19145	COG2203	Gaf domain
MW290_RS19145	COG2200	EAL domain
MW290_RS19170	COG1278	Cold shock
MW290_RS19175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MW290_RS19180	COG0542	response to heat
MW290_RS19185	COG3228	Belongs to the MtfA family
MW290_RS19190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MW290_RS19205	COG0215	cysteine-tRNA ligase activity
MW290_RS19220	COG0037	tRNA processing
MW290_RS19240	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MW290_RS19245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MW290_RS19265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MW290_RS19270	COG1070	Carbohydrate kinase
MW290_RS19280	COG4214	carbohydrate transport
MW290_RS19310	COG0351	phosphomethylpyrimidine kinase
MW290_RS19330	COG0352	thiamine-phosphate diphosphorylase activity
MW290_RS19345	COG3119	arylsulfatase activity
MW290_RS19355	COG2176	DNA-directed DNA polymerase activity
MW290_RS19365	COG0583	DNA-binding transcription factor activity
MW290_RS19370	COG0492	ferredoxin-NADP+ reductase activity
MW290_RS19375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MW290_RS19385	COG2895	sulfate adenylyltransferase (ATP) activity
MW290_RS19390	COG0175	sulfate reduction
MW290_RS19395	COG0175	sulfate reduction
MW290_RS19410	COG0730	response to heat
MW290_RS19415	COG1752	Esterase of the alpha-beta hydrolase superfamily
MW290_RS19425	COG0123	including yeast histone deacetylase and acetoin utilization protein
MW290_RS19430	COG0824	Thioesterase
MW290_RS19430	COG1250	3-hydroxyacyl-CoA dehydrogenase
MW290_RS19470	COG0826	peptidase U32
MW290_RS19475	COG0156	8-amino-7-oxononanoate synthase activity
MW290_RS19490	COG1393	Belongs to the ArsC family
MW290_RS19500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MW290_RS19505	COG4566	intracellular signal transduction
MW290_RS19515	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MW290_RS19520	COG0508	dehydrogenase complex catalyzes the overall conversion of
MW290_RS19525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MW290_RS19575	COG0625	glutathione transferase activity
MW290_RS19590	COG3243	poly(R)-hydroxyalkanoic acid synthase
MW290_RS19595	COG0183	Belongs to the thiolase family
MW290_RS19600	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS19610	COG2918	glutathione biosynthetic process
MW290_RS19615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MW290_RS19620	COG0024	Methionine aminopeptidase
MW290_RS19625	COG0047	phosphoribosylformylglycinamidine synthase activity
MW290_RS19625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MW290_RS19650	COG2059	Chromate
MW290_RS19660	COG2814	Major facilitator Superfamily
MW290_RS19665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MW290_RS19685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MW290_RS19695	COG1764	response to oxidative stress
MW290_RS19700	COG1846	Transcriptional regulator
MW290_RS19705	COG0488	(ABC) transporter
MW290_RS19710	COG2890	protein-(glutamine-N5) methyltransferase activity
MW290_RS19715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MW290_RS19725	COG2171	N-acyltransferase activity
MW290_RS19735	COG0596	Alpha beta hydrolase
MW290_RS19740	COG0473	3-isopropylmalate dehydrogenase activity
MW290_RS19750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MW290_RS19755	COG1196	nuclear chromosome segregation
MW290_RS19775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MW290_RS19780	COG0242	peptide deformylase activity
MW290_RS19795	COG4181	ATPase activity
MW290_RS19800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MW290_RS19810	COG2917	probably involved in intracellular septation
MW290_RS19815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MW290_RS19825	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS19845	COG0411	ABC transporter
MW290_RS19855	COG1024	Enoyl-CoA hydratase
MW290_RS19855	COG1250	3-hydroxyacyl-CoA dehydrogenase
MW290_RS19860	COG0183	Belongs to the thiolase family
MW290_RS19865	COG1960	acyl-CoA dehydrogenase activity
MW290_RS19885	COG2130	NADP-dependent
MW290_RS19890	COG2153	protein acetylation
MW290_RS19910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MW290_RS19910	COG1042	CoA-binding domain protein
MW290_RS19910	COG0045	succinate-CoA ligase (ADP-forming) activity
MW290_RS19915	COG0123	including yeast histone deacetylase and acetoin utilization protein
MW290_RS19925	COG2183	response to ionizing radiation
MW290_RS19930	COG0438	transferase activity, transferring glycosyl groups
MW290_RS19935	COG1649	PFAM Uncharacterised BCR, COG1649
MW290_RS19935	COG0726	polysaccharide deacetylase
MW290_RS19940	COG2032	superoxide dismutase activity
MW290_RS19945	COG2943	transferase activity, transferring hexosyl groups
MW290_RS19975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MW290_RS19980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MW290_RS19985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MW290_RS19990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MW290_RS19995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MW290_RS20000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MW290_RS20000	COG0072	phenylalanine-tRNA ligase activity
MW290_RS20005	COG0776	regulation of translation
MW290_RS20025	COG1918	ferrous iron import across plasma membrane
MW290_RS20025	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MW290_RS20040	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
MW290_RS20045	COG0308	aminopeptidase N
MW290_RS20055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MW290_RS20070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MW290_RS20080	COG0667	Aldo Keto reductase
MW290_RS20090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MW290_RS20095	COG0251	oxidation-reduction process
MW290_RS20105	COG0009	L-threonylcarbamoyladenylate synthase
MW290_RS20110	COG2198	Histidine kinase
MW290_RS20110	COG0784	Response regulator, receiver
MW290_RS20110	COG5002	protein histidine kinase activity
MW290_RS20135	COG2304	oxidoreductase activity
MW290_RS20145	COG0714	Associated with various cellular activities
MW290_RS20150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS20155	COG0084	hydrolase, TatD family'
MW290_RS20170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MW290_RS20175	COG0784	Response regulator, receiver
MW290_RS20175	COG5002	protein histidine kinase activity
MW290_RS20205	COG0697	spore germination
MW290_RS20210	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS20220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MW290_RS20225	COG0583	DNA-binding transcription factor activity
MW290_RS20230	COG0697	spore germination
MW290_RS20250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MW290_RS20295	COG3609	addiction module antidote protein, CC2985 family
MW290_RS20305	COG0840	transmembrane signaling receptor activity
MW290_RS20315	COG0583	DNA-binding transcription factor activity
MW290_RS20325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MW290_RS20330	COG1253	flavin adenine dinucleotide binding
MW290_RS20345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MW290_RS20350	COG0612	Peptidase, M16
MW290_RS20355	COG2202	Pas domain
MW290_RS20355	COG2205	protein histidine kinase activity
MW290_RS20370	COG1024	Enoyl-CoA hydratase
MW290_RS20375	COG1022	Amp-dependent synthetase and ligase
MW290_RS20385	COG1960	acyl-CoA dehydrogenase activity
MW290_RS20390	COG4691	Plasmid stability protein
MW290_RS20410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MW290_RS20430	COG1250	3-hydroxyacyl-CoA dehydrogenase
MW290_RS20450	COG1309	transcriptional regulator
MW290_RS20475	COG0579	oxidoreductase
MW290_RS20490	COG0463	Glycosyl transferase, family 2
MW290_RS20525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MW290_RS20560	COG3278	Belongs to the heme-copper respiratory oxidase family
MW290_RS20580	COG0137	argininosuccinate synthase activity
MW290_RS20585	COG1396	sequence-specific DNA binding
MW290_RS20605	COG0392	lysyltransferase activity
MW290_RS20610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MW290_RS20615	COG3568	Endonuclease Exonuclease Phosphatase
MW290_RS20655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS20660	COG0534	Mate efflux family protein
MW290_RS20685	COG0642	Histidine kinase
MW290_RS20690	COG0400	carboxylic ester hydrolase activity
MW290_RS20700	COG0840	transmembrane signaling receptor activity
MW290_RS20705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MW290_RS20710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MW290_RS20720	COG0268	Binds directly to 16S ribosomal RNA
MW290_RS20725	COG0728	peptidoglycan biosynthetic process
MW290_RS20730	COG2912	Transglutaminase-like superfamily
MW290_RS20745	COG0617	tRNA 3'-terminal CCA addition
MW290_RS20755	COG1428	Deoxynucleoside kinase
MW290_RS20765	COG0306	phosphate transporter
MW290_RS20780	COG0228	four-way junction DNA binding
MW290_RS20785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MW290_RS20790	COG0336	Belongs to the RNA methyltransferase TrmD family
MW290_RS20795	COG0335	large ribosomal subunit rRNA binding
MW290_RS20810	COG1162	GTPase activity
MW290_RS20815	COG0501	Belongs to the peptidase M48B family
MW290_RS20820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MW290_RS20825	COG0513	Belongs to the DEAD box helicase family
MW290_RS20830	COG3344	reverse transcriptase
MW290_RS20840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MW290_RS20845	COG0583	DNA-binding transcription factor activity
MW290_RS20850	COG1741	Belongs to the pirin family
MW290_RS20865	COG1054	Belongs to the UPF0176 family
MW290_RS20895	COG0438	transferase activity, transferring glycosyl groups
MW290_RS20905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MW290_RS20910	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MW290_RS20915	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MW290_RS20920	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MW290_RS20925	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MW290_RS20935	COG0776	regulation of translation
MW290_RS20945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MW290_RS20950	COG0287	Prephenate dehydrogenase
MW290_RS20955	COG0077	Prephenate dehydratase
MW290_RS20955	COG1605	Chorismate mutase
MW290_RS20975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MW290_RS20990	COG0582	viral genome integration into host DNA
MW290_RS21070	COG5642	Protein of unknown function (DUF2384)
MW290_RS21090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MW290_RS21095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MW290_RS21105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MW290_RS21110	COG0589	response to stress
MW290_RS21115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MW290_RS21120	COG1414	Transcriptional regulator
MW290_RS21150	COG1546	Belongs to the CinA family
MW290_RS21150	COG1058	Belongs to the CinA family
MW290_RS21155	COG0174	glutamine synthetase
MW290_RS21165	COG3852	Histidine kinase
MW290_RS21210	COG0840	transmembrane signaling receptor activity
MW290_RS21215	COG0402	S-adenosylhomocysteine deaminase activity
MW290_RS21245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MW290_RS21250	COG0300	oxidoreductase activity
MW290_RS21255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS21260	COG1335	isochorismatase
MW290_RS21265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS21300	COG2010	Cytochrome c
MW290_RS21300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MW290_RS21305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MW290_RS21315	COG0625	glutathione transferase activity
MW290_RS21330	COG0483	inositol monophosphate 1-phosphatase activity
MW290_RS21345	COG1473	amidohydrolase
MW290_RS21370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS21385	COG1522	sequence-specific DNA binding
MW290_RS21395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MW290_RS21405	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS21415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS21425	COG0601	transmembrane transport
MW290_RS21450	COG2204	response regulator
MW290_RS21465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MW290_RS21500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS21515	COG0438	transferase activity, transferring glycosyl groups
MW290_RS21545	COG1335	isochorismatase
MW290_RS21550	COG4251	negative regulation of phosphorylation
MW290_RS21575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW290_RS21580	COG1522	sequence-specific DNA binding
MW290_RS21585	COG3706	GGDEF domain
MW290_RS21605	COG3250	beta-galactosidase activity
MW290_RS21615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MW290_RS21620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS21640	COG0840	transmembrane signaling receptor activity
MW290_RS21645	COG0745	RESPONSE REGULATOR receiver
MW290_RS21655	COG0643	Histidine kinase
MW290_RS21655	COG2198	Histidine kinase
MW290_RS21660	COG0643	Histidine kinase
MW290_RS21660	COG0784	Response regulator, receiver
MW290_RS21660	COG2198	Histidine kinase
MW290_RS21665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MW290_RS21675	COG2201	protein-glutamate methylesterase activity
MW290_RS21685	COG0840	transmembrane signaling receptor activity
MW290_RS21685	COG3290	protein histidine kinase activity
MW290_RS21690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MW290_RS21725	COG0438	transferase activity, transferring glycosyl groups
MW290_RS21730	COG2835	tetraacyldisaccharide 4'-kinase activity
MW290_RS21740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MW290_RS21745	COG0438	transferase activity, transferring glycosyl groups
MW290_RS21750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MW290_RS21760	COG4555	ABC transporter
MW290_RS21770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MW290_RS21790	COG0438	transferase activity, transferring glycosyl groups
MW290_RS21795	COG0438	transferase activity, transferring glycosyl groups
MW290_RS21805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MW290_RS21855	COG3795	YCII-related domain
MW290_RS21875	COG3781	membrane
MW290_RS21880	COG0628	permease
MW290_RS21910	COG1408	metallophosphoesterase
MW290_RS21920	COG5002	protein histidine kinase activity
MW290_RS21920	COG2205	protein histidine kinase activity
MW290_RS21920	COG0784	Response regulator, receiver
MW290_RS21930	COG4771	TonB-dependent receptor
MW290_RS21950	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MW290_RS21955	COG1522	sequence-specific DNA binding
MW290_RS21960	COG4335	DNA alkylation repair
MW290_RS21965	COG2233	PERMEase
MW290_RS22025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MW290_RS22095	COG2076	Multidrug Resistance protein
MW290_RS22145	COG2433	Pfam Transposase IS66
MW290_RS22170	COG0587	DNA-directed DNA polymerase activity
MW290_RS22235	COG1132	(ABC) transporter
MW290_RS22245	COG1538	Outer membrane efflux protein
MW290_RS22250	COG1566	PFAM secretion protein HlyD family protein
MW290_RS22255	COG2814	Major facilitator Superfamily
MW290_RS22260	COG3706	GGDEF domain
MW290_RS22275	COG1136	(ABC) transporter
MW290_RS22280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MW290_RS22285	COG2814	Major facilitator Superfamily
MW290_RS22300	COG0840	transmembrane signaling receptor activity
MW290_RS22310	COG0745	RESPONSE REGULATOR receiver
MW290_RS22315	COG2205	protein histidine kinase activity
MW290_RS22320	COG4452	Inner membrane protein CreD
MW290_RS22330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MW290_RS22335	COG0586	Pfam SNARE associated Golgi protein
MW290_RS22345	COG0860	N-Acetylmuramoyl-L-alanine amidase
MW290_RS22350	COG0802	atpase or kinase
MW290_RS22355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MW290_RS22370	COG4974	Belongs to the 'phage' integrase family
MW290_RS22380	COG2095	MarC family integral membrane protein
MW290_RS22385	COG0765	amino acid transport
MW290_RS22395	COG2833	Protein of unknown function (DUF455)
MW290_RS22400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MW290_RS22410	COG3201	nicotinamide mononucleotide transporter
MW290_RS22415	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MW290_RS22420	COG0148	phosphopyruvate hydratase activity
MW290_RS22430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
MW290_RS22435	COG0504	CTP synthase activity
MW290_RS22440	COG2267	carboxylic ester hydrolase activity
MW290_RS22450	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MW290_RS22460	COG0483	inositol monophosphate 1-phosphatase activity
MW290_RS22470	COG1045	serine acetyltransferase
MW290_RS22480	COG0521	Mo-molybdopterin cofactor biosynthetic process
MW290_RS22485	COG3028	Belongs to the UPF0307 family
MW290_RS22490	COG0312	modulator of DNA gyrase
MW290_RS22495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MW290_RS22515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS22535	COG4974	Belongs to the 'phage' integrase family
MW290_RS22540	COG0517	IMP dehydrogenase activity
MW290_RS22565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MW290_RS22570	COG2081	HI0933 family
MW290_RS22575	COG0569	domain protein
MW290_RS22580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MW290_RS22585	COG0840	transmembrane signaling receptor activity
MW290_RS22600	COG0643	Histidine kinase
MW290_RS22600	COG2198	Histidine kinase
MW290_RS22620	COG0835	chemotaxis
MW290_RS22645	COG5001	Diguanylate cyclase
MW290_RS22645	COG3300	MHYT domain
MW290_RS22655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MW290_RS22660	COG0243	molybdopterin cofactor binding
MW290_RS22675	COG0730	response to heat
MW290_RS22695	COG4206	TonB-dependent receptor
MW290_RS22705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MW290_RS22710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MW290_RS22725	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MW290_RS22730	COG1492	cobalamin metabolic process
MW290_RS22735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MW290_RS22740	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MW290_RS22755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MW290_RS22760	COG2878	Part of a membrane complex involved in electron transport
MW290_RS22775	COG0556	nucleotide-excision repair
MW290_RS22780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MW290_RS22785	COG1959	2 iron, 2 sulfur cluster binding
MW290_RS22790	COG1104	cysteine desulfurase activity
MW290_RS22795	COG0822	iron-sulfur transferase activity
MW290_RS22810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MW290_RS22815	COG0443	Heat shock 70 kDa protein
MW290_RS22820	COG0633	Ferredoxin
MW290_RS22830	COG1116	anion transmembrane transporter activity
MW290_RS22835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS22840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS22845	COG3707	response regulator
MW290_RS22850	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MW290_RS22865	COG0583	DNA-binding transcription factor activity
MW290_RS22870	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS22895	COG2944	sequence-specific DNA binding
MW290_RS22900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MW290_RS22920	COG1451	nucleotide metabolic process
MW290_RS22945	COG0513	Belongs to the DEAD box helicase family
MW290_RS22955	COG2199	diguanylate cyclase activity
MW290_RS22955	COG2200	EAL domain
MW290_RS22955	COG2202	Pas domain
MW290_RS22985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MW290_RS23010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MW290_RS23020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MW290_RS23030	COG3842	ATPase activity
MW290_RS23035	COG1840	ABC-type Fe3 transport system, periplasmic component
MW290_RS23070	COG1619	proteins homologs of microcin C7 resistance protein MccF
MW290_RS23080	COG0601	transmembrane transport
MW290_RS23090	COG4172	Belongs to the ABC transporter superfamily
MW290_RS23100	COG4206	TonB-dependent receptor
MW290_RS23115	COG0563	adenylate kinase activity
MW290_RS23120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MW290_RS23125	COG2835	tetraacyldisaccharide 4'-kinase activity
MW290_RS23130	COG1663	tetraacyldisaccharide 4'-kinase activity
MW290_RS23140	COG0811	peptide transport
MW290_RS23145	COG1570	exodeoxyribonuclease VII activity
MW290_RS23150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MW290_RS23160	COG1309	transcriptional regulator
MW290_RS23170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MW290_RS23180	COG2194	sulfuric ester hydrolase activity
MW290_RS23195	COG0642	Histidine kinase
MW290_RS23205	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MW290_RS23205	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MW290_RS23210	COG1703	isobutyryl-CoA mutase activity
MW290_RS23215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MW290_RS23220	COG4770	biotin carboxylase activity
MW290_RS23225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MW290_RS23275	COG0446	pyridine nucleotide-disulphide oxidoreductase
MW290_RS23280	COG2186	Transcriptional regulator
MW290_RS23285	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS23295	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MW290_RS23320	COG1879	ABC-type sugar transport system periplasmic component
MW290_RS23325	COG1129	ABC transporter
MW290_RS23330	COG1172	Belongs to the binding-protein-dependent transport system permease family
MW290_RS23340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MW290_RS23345	COG1869	D-ribose catabolic process
MW290_RS23375	COG0642	Histidine kinase
MW290_RS23395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MW290_RS23430	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MW290_RS23450	COG1538	Outer membrane efflux protein
MW290_RS23455	COG0745	RESPONSE REGULATOR receiver
MW290_RS23460	COG2205	protein histidine kinase activity
MW290_RS23480	COG2205	protein histidine kinase activity
MW290_RS23485	COG0745	RESPONSE REGULATOR receiver
MW290_RS23490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MW290_RS23495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MW290_RS23505	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS23510	COG2010	Cytochrome c
MW290_RS23510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MW290_RS23520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS23525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS23530	COG1116	anion transmembrane transporter activity
MW290_RS23545	COG0864	Transcriptional regulator
MW290_RS23565	COG1802	Transcriptional regulator
MW290_RS23575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MW290_RS23595	COG0129	dihydroxy-acid dehydratase activity
MW290_RS23600	COG3622	Belongs to the hyi family
MW290_RS23605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS23630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MW290_RS23630	COG0519	Catalyzes the synthesis of GMP from XMP
MW290_RS23655	COG2914	Belongs to the UPF0125 (RnfH) family
MW290_RS23660	COG2867	negative regulation of translational initiation
MW290_RS23665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MW290_RS23670	COG0626	cystathionine gamma-synthase activity
MW290_RS23675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MW290_RS23695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MW290_RS23700	COG0725	ABC transporter, periplasmic molybdate-binding protein
MW290_RS23705	COG4149	molybdate abc transporter
MW290_RS23710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MW290_RS23725	COG4948	Mandelate Racemase Muconate Lactonizing
MW290_RS23730	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS23735	COG1609	Transcriptional regulator
MW290_RS23755	COG3958	Transketolase
MW290_RS23760	COG3959	Transketolase, thiamine diphosphate binding domain
MW290_RS23765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS23775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS23780	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS23785	COG0583	DNA-binding transcription factor activity
MW290_RS23790	COG1802	Transcriptional regulator
MW290_RS23815	COG0778	Nitroreductase
MW290_RS23825	COG0583	DNA-binding transcription factor activity
MW290_RS23855	COG0784	Response regulator, receiver
MW290_RS23855	COG2198	Histidine kinase
MW290_RS23855	COG5002	protein histidine kinase activity
MW290_RS23880	COG0174	glutamine synthetase
MW290_RS23885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MW290_RS23900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MW290_RS23910	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS23940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MW290_RS23940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MW290_RS23945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MW290_RS23950	COG3384	dioxygenase
MW290_RS23960	COG1733	regulation of RNA biosynthetic process
MW290_RS23965	COG0251	oxidation-reduction process
MW290_RS23970	COG0840	transmembrane signaling receptor activity
MW290_RS23975	COG0560	Phosphoserine phosphatase
MW290_RS23985	COG1643	Atp-dependent helicase
MW290_RS23990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MW290_RS23990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MW290_RS23995	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
MW290_RS24000	COG1840	ABC-type Fe3 transport system, periplasmic component
MW290_RS24020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MW290_RS24030	COG2202	Pas domain
MW290_RS24030	COG2205	protein histidine kinase activity
MW290_RS24035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MW290_RS24050	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS24060	COG0642	Histidine kinase
MW290_RS24070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MW290_RS24075	COG0443	Heat shock 70 kDa protein
MW290_RS24080	COG0484	heat shock protein binding
MW290_RS24100	COG0359	binds to the 23S rRNA
MW290_RS24105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MW290_RS24110	COG2965	DNA replication, synthesis of RNA primer
MW290_RS24115	COG0360	Binds together with S18 to 16S ribosomal RNA
MW290_RS24120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MW290_RS24130	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MW290_RS24135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MW290_RS24140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MW290_RS24145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MW290_RS24150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MW290_RS24155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MW290_RS24160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MW290_RS24175	COG0750	zinc metalloprotease
MW290_RS24180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MW290_RS24185	COG0575	Belongs to the CDS family
MW290_RS24195	COG0233	cytoplasmic translational termination
MW290_RS24200	COG0528	UMP kinase activity
MW290_RS24205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MW290_RS24210	COG0052	Belongs to the universal ribosomal protein uS2 family
MW290_RS24215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS24220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MW290_RS24220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MW290_RS24225	COG0557	exoribonuclease II activity
MW290_RS24240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MW290_RS24245	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MW290_RS24250	COG0330	HflC and HflK could
MW290_RS24255	COG0330	HflC and HflK could
MW290_RS24260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MW290_RS24265	COG1923	regulation of RNA biosynthetic process
MW290_RS24270	COG1160	GTP binding
MW290_RS24285	COG0124	histidyl-tRNA synthetase
MW290_RS24290	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MW290_RS24305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MW290_RS24310	COG0105	UTP biosynthetic process
MW290_RS24315	COG1187	pseudouridine synthase activity
MW290_RS24320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MW290_RS24325	COG0564	pseudouridine synthase activity
MW290_RS24335	COG1199	ATP-dependent helicase activity
MW290_RS24355	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MW290_RS24360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MW290_RS24365	COG0508	dehydrogenase complex catalyzes the overall conversion of
MW290_RS24370	COG0567	Dehydrogenase, E1 component
MW290_RS24380	COG2201	protein-glutamate methylesterase activity
MW290_RS24390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MW290_RS24395	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MW290_RS24400	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
MW290_RS24405	COG3639	organic phosphonate transmembrane transporter activity
MW290_RS24410	COG3639	organic phosphonate transmembrane transporter activity
MW290_RS24415	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
MW290_RS24420	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
MW290_RS24430	COG2202	Pas domain
MW290_RS24430	COG2205	protein histidine kinase activity
MW290_RS24435	COG3437	response regulator, receiver
MW290_RS24450	COG0437	4 iron, 4 sulfur cluster binding
MW290_RS24455	COG2864	formate dehydrogenase
MW290_RS24465	COG1921	L-seryl-tRNASec selenium transferase activity
MW290_RS24470	COG3276	selenocysteine insertion sequence binding
MW290_RS24480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MW290_RS24485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MW290_RS24500	COG3433	isochorismatase activity
MW290_RS24500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MW290_RS24500	COG2226	methyltransferase
MW290_RS24515	COG1522	sequence-specific DNA binding
MW290_RS24520	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS24525	COG0667	Aldo Keto reductase
MW290_RS24530	COG0071	Belongs to the small heat shock protein (HSP20) family
MW290_RS24535	COG0071	Belongs to the small heat shock protein (HSP20) family
MW290_RS24540	COG3549	Plasmid maintenance system killer
MW290_RS24550	COG4636	protein conserved in cyanobacteria
MW290_RS24555	COG2030	dehydratase
MW290_RS24555	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS24560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MW290_RS24565	COG2151	metal-sulfur cluster biosynthetic enzyme
MW290_RS24570	COG3396	Phenylacetate-CoA oxygenase
MW290_RS24575	COG3460	Phenylacetate-CoA oxygenase
MW290_RS24580	COG3396	Phenylacetate-CoA oxygenase
MW290_RS24585	COG1024	Enoyl-CoA hydratase
MW290_RS24590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MW290_RS24615	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS24650	COG3179	chitinase
MW290_RS24810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MW290_RS24815	COG1522	sequence-specific DNA binding
MW290_RS24820	COG0697	spore germination
MW290_RS24835	COG0028	Belongs to the TPP enzyme family
MW290_RS24860	COG4772	TonB-dependent receptor
MW290_RS24885	COG0542	response to heat
MW290_RS24895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MW290_RS24900	COG0314	molybdopterin synthase activity
MW290_RS24905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MW290_RS24910	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MW290_RS24915	COG0303	'Molybdopterin
MW290_RS24920	COG1763	Mo-molybdopterin cofactor biosynthetic process
MW290_RS24935	COG0436	Aminotransferase
MW290_RS24945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MW290_RS24950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MW290_RS24955	COG0840	transmembrane signaling receptor activity
MW290_RS24960	COG0339	signal peptide processing
MW290_RS24970	COG0791	NLP P60 protein
MW290_RS24980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MW290_RS24985	COG0746	molybdenum cofactor guanylyltransferase activity
MW290_RS24990	COG0456	acetyltransferase
MW290_RS24995	COG0328	RNA-DNA hybrid ribonuclease activity
MW290_RS25005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MW290_RS25010	COG0741	lytic transglycosylase activity
MW290_RS25010	COG1388	LysM domain
MW290_RS25015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MW290_RS25020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MW290_RS25025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MW290_RS25030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MW290_RS25050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MW290_RS25055	COG0254	rRNA binding
MW290_RS25065	COG5002	protein histidine kinase activity
MW290_RS25070	COG0745	RESPONSE REGULATOR receiver
MW290_RS25080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MW290_RS25085	COG0581	inorganic phosphate transmembrane transporter activity
MW290_RS25090	COG0573	inorganic phosphate transmembrane transporter activity
MW290_RS25095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MW290_RS25100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MW290_RS25110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MW290_RS25115	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MW290_RS25120	COG1534	Rna-binding protein
MW290_RS25130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MW290_RS25135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MW290_RS25145	COG0505	Belongs to the CarA family
MW290_RS25150	COG3193	protein, possibly involved in utilization of glycolate and propanediol
MW290_RS25155	COG0670	Belongs to the BI1 family
MW290_RS25160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MW290_RS25175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MW290_RS25180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MW290_RS25185	COG2130	NADP-dependent
MW290_RS25190	COG2197	response regulator
MW290_RS25225	COG2226	methyltransferase
MW290_RS25235	COG1960	acyl-CoA dehydrogenase activity
MW290_RS25250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MW290_RS25265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MW290_RS25285	COG2831	hemolysin activation secretion protein
MW290_RS25350	COG2226	methyltransferase
MW290_RS25390	COG0631	protein serine/threonine phosphatase activity
MW290_RS25430	COG3161	chorismate lyase activity
MW290_RS25635	COG0629	single-stranded DNA binding
MW290_RS25695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MW290_RS25700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MW290_RS25705	COG0740	serine-type endopeptidase activity
MW290_RS25710	COG0544	peptidyl-prolyl cis-trans isomerase activity
MW290_RS25720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MW290_RS25740	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
MW290_RS25750	COG1414	Transcriptional regulator
MW290_RS25760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MW290_RS25765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MW290_RS25770	COG1183	phosphatidylcholine synthase activity
MW290_RS25775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MW290_RS25780	COG0440	acetolactate synthase activity
MW290_RS25785	COG0028	Belongs to the TPP enzyme family
MW290_RS25820	COG0347	Belongs to the P(II) protein family
MW290_RS25830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MW290_RS25840	COG5002	protein histidine kinase activity
MW290_RS25840	COG2205	protein histidine kinase activity
MW290_RS25840	COG0784	Response regulator, receiver
MW290_RS25845	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MW290_RS25855	COG2205	protein histidine kinase activity
MW290_RS25870	COG0784	Response regulator, receiver
MW290_RS25870	COG2205	protein histidine kinase activity
MW290_RS25870	COG5002	protein histidine kinase activity
MW290_RS25880	COG0436	Aminotransferase
MW290_RS25890	COG0459	protein refolding
MW290_RS25895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MW290_RS25900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS25945	COG3220	belongs to the UPF0276 family
MW290_RS25955	COG1595	DNA-templated transcription, initiation
MW290_RS25965	COG4770	biotin carboxylase activity
MW290_RS25970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MW290_RS25975	COG4336	lyase activity
MW290_RS25980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MW290_RS25985	COG2814	Major facilitator Superfamily
MW290_RS25990	COG1802	Transcriptional regulator
MW290_RS25995	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MW290_RS26035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MW290_RS26045	COG0668	transmembrane transport
MW290_RS26050	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MW290_RS26055	COG1960	acyl-CoA dehydrogenase activity
MW290_RS26060	COG1960	acyl-CoA dehydrogenase activity
MW290_RS26065	COG0584	glycerophosphoryl diester phosphodiesterase
MW290_RS26070	COG3191	aminopeptidase activity
MW290_RS26075	COG1187	pseudouridine synthase activity
MW290_RS26080	COG0196	riboflavin kinase activity
MW290_RS26095	COG0395	ABC-type sugar transport system, permease component
MW290_RS26100	COG1175	transmembrane transport
MW290_RS26105	COG1653	transport
MW290_RS26115	COG0642	Histidine kinase
MW290_RS26135	COG2199	diguanylate cyclase activity
MW290_RS26135	COG2203	Gaf domain
MW290_RS26150	COG2205	protein histidine kinase activity
MW290_RS26150	COG4999	Histidine kinase
MW290_RS26150	COG3850	Histidine kinase
MW290_RS26150	COG3437	response regulator, receiver
MW290_RS26155	COG2816	NAD+ diphosphatase activity
MW290_RS26160	COG0154	amidase activity
MW290_RS26170	COG3609	addiction module antidote protein, CC2985 family
MW290_RS26180	COG4580	involved in the transport of maltose and maltodextrins
MW290_RS26190	COG1175	transmembrane transport
MW290_RS26195	COG0395	ABC-type sugar transport system, permease component
MW290_RS26200	COG3842	ATPase activity
MW290_RS26230	COG5002	protein histidine kinase activity
MW290_RS26230	COG2198	Histidine kinase
MW290_RS26230	COG0784	Response regulator, receiver
MW290_RS26235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MW290_RS26240	COG0564	pseudouridine synthase activity
MW290_RS26245	COG1054	Belongs to the UPF0176 family
MW290_RS26255	COG2094	Belongs to the DNA glycosylase MPG family
MW290_RS26270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS26290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS26295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MW290_RS26300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS26310	COG4948	Mandelate Racemase Muconate Lactonizing
MW290_RS26320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS26325	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS26335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MW290_RS26340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MW290_RS26345	COG0583	DNA-binding transcription factor activity
MW290_RS26350	COG0129	dihydroxy-acid dehydratase activity
MW290_RS26395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MW290_RS26400	COG1320	monovalent cation:proton antiporter activity
MW290_RS26405	COG2212	antiporter activity
MW290_RS26415	COG0651	ATP synthesis coupled electron transport
MW290_RS26420	COG1006	Multisubunit Na H antiporter MnhC subunit
MW290_RS26425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MW290_RS26425	COG2111	Na H antiporter
MW290_RS26450	COG0668	transmembrane transport
MW290_RS26455	COG0123	including yeast histone deacetylase and acetoin utilization protein
MW290_RS26460	COG0714	Associated with various cellular activities
MW290_RS26475	COG2951	lytic endotransglycosylase activity
MW290_RS26480	COG3550	peptidyl-serine autophosphorylation
MW290_RS26485	COG1396	sequence-specific DNA binding
MW290_RS26495	COG2308	Evidence 4 Homologs of previously reported genes of
MW290_RS26540	COG1349	DNA-binding transcription factor activity
MW290_RS26550	COG4251	negative regulation of phosphorylation
MW290_RS26590	COG2084	Dehydrogenase
MW290_RS26595	COG3622	Belongs to the hyi family
MW290_RS26600	COG3960	tartronate-semialdehyde synthase activity
MW290_RS26605	COG1301	dicarboxylic acid transport
MW290_RS26610	COG2204	response regulator
MW290_RS26615	COG4191	Histidine kinase
MW290_RS26625	COG2186	Transcriptional regulator
MW290_RS26630	COG1301	dicarboxylic acid transport
MW290_RS26640	COG0583	DNA-binding transcription factor activity
MW290_RS26675	COG1346	cytolysis
MW290_RS26685	COG2233	PERMEase
MW290_RS26715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MW290_RS26725	COG3437	response regulator, receiver
MW290_RS26725	COG3850	Histidine kinase
MW290_RS26725	COG4999	Histidine kinase
MW290_RS26725	COG2205	protein histidine kinase activity
MW290_RS26730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS26735	COG1116	anion transmembrane transporter activity
MW290_RS26740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS26745	COG0194	GDP metabolic process
MW290_RS26750	COG1758	RNA polymerase activity
MW290_RS26755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MW290_RS26765	COG2982	Protein involved in outer membrane biogenesis
MW290_RS26775	COG2995	paraquat-inducible protein a
MW290_RS26820	COG2197	response regulator
MW290_RS26835	COG5487	UPF0391 membrane protein
MW290_RS26870	COG1295	ribonuclease BN
MW290_RS26880	COG2111	Na H antiporter
MW290_RS26880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MW290_RS26885	COG1006	Multisubunit Na H antiporter MnhC subunit
MW290_RS26890	COG0651	ATP synthesis coupled electron transport
MW290_RS26900	COG2212	antiporter activity
MW290_RS26905	COG1320	monovalent cation:proton antiporter activity
MW290_RS26910	COG3409	Peptidoglycan-binding domain 1 protein
MW290_RS26910	COG3267	Type II secretory pathway component ExeA
MW290_RS26950	COG0840	transmembrane signaling receptor activity
MW290_RS26955	COG0784	Response regulator, receiver
MW290_RS26955	COG2205	protein histidine kinase activity
MW290_RS26955	COG2198	Histidine kinase
MW290_RS26960	COG0745	RESPONSE REGULATOR receiver
MW290_RS26965	COG2205	protein histidine kinase activity
MW290_RS26990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MW290_RS26995	COG0033	Phosphoglucomutase
MW290_RS27000	COG2814	Major facilitator Superfamily
MW290_RS27025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MW290_RS27035	COG0583	DNA-binding transcription factor activity
MW290_RS27050	COG0831	urea catabolic process
MW290_RS27060	COG0832	Belongs to the urease beta subunit family
MW290_RS27065	COG0804	urea catabolic process
MW290_RS27075	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MW290_RS27080	COG0830	nickel cation binding
MW290_RS27085	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MW290_RS27090	COG1652	LysM domain
MW290_RS27105	COG0598	Magnesium transport protein CorA
MW290_RS27115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MW290_RS27115	COG0616	signal peptide processing
MW290_RS27130	COG0564	pseudouridine synthase activity
MW290_RS27135	COG1530	ribonuclease E activity
MW290_RS27140	COG1472	Belongs to the glycosyl hydrolase 3 family
MW290_RS27145	COG0736	holo-[acyl-carrier-protein] synthase activity
MW290_RS27150	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MW290_RS27155	COG1381	Involved in DNA repair and RecF pathway recombination
MW290_RS27160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MW290_RS27165	COG0571	ribonuclease III activity
MW290_RS27175	COG0681	Belongs to the peptidase S26 family
MW290_RS27180	COG0481	GTPase activity
MW290_RS27185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS27190	COG3026	antisigma factor binding
MW290_RS27210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MW290_RS27215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MW290_RS27220	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS27225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MW290_RS27230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MW290_RS27235	COG0416	fatty acid biosynthetic process
MW290_RS27240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MW290_RS27245	COG1399	metal-binding, possibly nucleic acid-binding protein
MW290_RS27250	COG0424	maF-like protein
MW290_RS27260	COG0513	Belongs to the DEAD box helicase family
MW290_RS27265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MW290_RS27305	COG3959	Transketolase, thiamine diphosphate binding domain
MW290_RS27310	COG3958	Transketolase
MW290_RS27325	COG0110	maltose O-acetyltransferase activity
MW290_RS27360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MW290_RS27370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MW290_RS27375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MW290_RS27390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MW290_RS27395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MW290_RS27460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MW290_RS27475	COG1024	Enoyl-CoA hydratase
MW290_RS27500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MW290_RS27510	COG1741	Belongs to the pirin family
MW290_RS27515	COG0012	GTP binding
MW290_RS27520	COG2205	protein histidine kinase activity
MW290_RS27520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MW290_RS27525	COG0840	transmembrane signaling receptor activity
MW290_RS27535	COG1999	signal sequence binding
MW290_RS27540	COG0109	protoheme IX farnesyltransferase activity
MW290_RS27545	COG1612	heme a metabolic process
MW290_RS27575	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MW290_RS27600	COG2226	methyltransferase
MW290_RS27610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MW290_RS27615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MW290_RS27620	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MW290_RS27625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MW290_RS27630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MW290_RS27635	COG0588	phosphoglycerate mutase activity
MW290_RS27640	COG0204	Acyl-transferase
MW290_RS27650	COG0540	Belongs to the ATCase OTCase family
MW290_RS27655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MW290_RS27660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MW290_RS27665	COG1678	Uncharacterized ACR, COG1678
MW290_RS27675	COG0415	Belongs to the DNA photolyase family
MW290_RS27680	COG2198	Histidine kinase
MW290_RS27680	COG0643	Histidine kinase
MW290_RS27685	COG0840	transmembrane signaling receptor activity
MW290_RS27705	COG1773	rubredoxin
MW290_RS27715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MW290_RS27730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MW290_RS27740	COG3150	esterase
MW290_RS27745	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS27750	COG0557	exoribonuclease II activity
MW290_RS27760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MW290_RS27765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MW290_RS27775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MW290_RS27780	COG0511	ligase activity, forming carbon-carbon bonds
MW290_RS27785	COG0439	Biotin carboxylase
MW290_RS27790	COG2264	protein methyltransferase activity
MW290_RS27800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MW290_RS27820	COG3023	N-Acetylmuramoyl-L-alanine amidase
MW290_RS27845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MW290_RS27975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MW290_RS28025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MW290_RS28150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MW290_RS28190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MW290_RS28200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MW290_RS28205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MW290_RS28210	COG2890	protein-(glutamine-N5) methyltransferase activity
MW290_RS28220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MW290_RS28230	COG0741	lytic transglycosylase activity
MW290_RS28240	COG0442	prolyl-tRNA aminoacylation
MW290_RS28245	COG0494	nUDIX hydrolase
MW290_RS28250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MW290_RS28255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MW290_RS28260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MW290_RS28265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MW290_RS28270	COG0142	geranyltranstransferase activity
MW290_RS28290	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MW290_RS28300	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MW290_RS28305	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MW290_RS28310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MW290_RS28320	COG2204	response regulator
MW290_RS28325	COG0583	DNA-binding transcription factor activity
MW290_RS28380	COG4251	negative regulation of phosphorylation
MW290_RS28385	COG0784	Response regulator, receiver
MW290_RS28410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MW290_RS28415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MW290_RS28420	COG1793	dna ligase
MW290_RS28420	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MW290_RS28430	COG1793	dna ligase
MW290_RS28430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MW290_RS28435	COG3152	Membrane
MW290_RS28440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MW290_RS28450	COG0494	nUDIX hydrolase
MW290_RS28455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MW290_RS28470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MW290_RS28480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MW290_RS28490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MW290_RS28500	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MW290_RS28530	COG0438	transferase activity, transferring glycosyl groups
MW290_RS28540	COG0438	transferase activity, transferring glycosyl groups
MW290_RS28570	COG2894	cell division
MW290_RS28590	COG2226	methyltransferase
MW290_RS28610	COG1653	transport
MW290_RS28615	COG1175	transmembrane transport
MW290_RS28620	COG0395	ABC-type sugar transport system, permease component
MW290_RS28630	COG0584	glycerophosphoryl diester phosphodiesterase
MW290_RS28640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MW290_RS28645	COG0653	protein targeting
MW290_RS28660	COG2433	Pfam Transposase IS66
MW290_RS28685	COG2969	positive regulation of protein catabolic process
MW290_RS28690	COG0625	glutathione transferase activity
MW290_RS28695	COG2857	Cytochrome c1
MW290_RS28700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MW290_RS28705	COG0723	plastoquinol--plastocyanin reductase activity
MW290_RS28710	COG1970	mechanosensitive ion channel activity
MW290_RS28720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MW290_RS28730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MW290_RS28735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS28740	COG0805	protein transport
MW290_RS28745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MW290_RS28750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MW290_RS28765	COG0140	phosphoribosyl-ATP diphosphatase activity
MW290_RS28770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MW290_RS28775	COG0494	nUDIX hydrolase
MW290_RS28790	COG1309	transcriptional regulator
MW290_RS28805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MW290_RS28820	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MW290_RS28825	COG1238	metal cluster binding
MW290_RS28830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MW290_RS28835	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MW290_RS28840	COG0138	bifunctional purine biosynthesis protein purh
MW290_RS28855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MW290_RS28865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MW290_RS28875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MW290_RS28900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MW290_RS28905	COG1181	Belongs to the D-alanine--D-alanine ligase family
MW290_RS28910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MW290_RS28915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MW290_RS28925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MW290_RS28930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MW290_RS28935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MW290_RS28940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MW290_RS28955	COG0275	rRNA processing
MW290_RS28960	COG2001	Belongs to the MraZ family
MW290_RS28980	COG2197	response regulator
MW290_RS28985	COG0784	Response regulator, receiver
MW290_RS28985	COG2205	protein histidine kinase activity
MW290_RS28995	COG3344	reverse transcriptase
MW290_RS29005	COG0798	PFAM Bile acid sodium symporter
MW290_RS29015	COG0431	NADPH-dependent FMN reductase
MW290_RS29020	COG0583	DNA-binding transcription factor activity
MW290_RS29025	COG2814	Major facilitator Superfamily
MW290_RS29030	COG0656	L-ascorbic acid biosynthetic process
MW290_RS29080	COG1012	belongs to the aldehyde dehydrogenase family
MW290_RS29085	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
MW290_RS29090	COG0028	Belongs to the TPP enzyme family
MW290_RS29100	COG1414	Transcriptional regulator
MW290_RS29115	COG1028	Short-chain dehydrogenase reductase Sdr
MW290_RS29120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS29125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MW290_RS29145	COG3833	ABC-type maltose transport systems, permease component
MW290_RS29150	COG1176	ABC-type spermidine putrescine transport system, permease component I
MW290_RS29160	COG3842	ATPase activity
MW290_RS29190	COG2274	protein secretion by the type I secretion system
MW290_RS29205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MW290_RS29210	COG0751	glycine-tRNA ligase activity
MW290_RS29215	COG0752	glycyl-tRNA synthetase alpha subunit
MW290_RS29220	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MW290_RS29230	COG0523	cobalamin synthesis protein
MW290_RS29245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MW290_RS29250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MW290_RS29255	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MW290_RS29260	COG5265	(ABC) transporter
MW290_RS29275	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MW290_RS29280	COG3387	PFAM Glycoside hydrolase 15-related
MW290_RS29290	COG0668	transmembrane transport
MW290_RS29295	COG3039	Transposase
MW290_RS29310	COG1024	Enoyl-CoA hydratase
MW290_RS29315	COG0183	Belongs to the thiolase family
MW290_RS29320	COG1024	Enoyl-CoA hydratase
MW290_RS29320	COG1250	3-hydroxyacyl-CoA dehydrogenase
MW290_RS29330	COG1960	acyl-CoA dehydrogenase activity
MW290_RS29345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS29365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MW290_RS29365	COG2010	Cytochrome c
MW290_RS29380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MW290_RS29400	COG1538	Outer membrane efflux protein
MW290_RS29405	COG0688	phosphatidylethanolamine metabolic process
MW290_RS29410	COG0235	Class ii aldolase
MW290_RS29415	COG1942	4-Oxalocrotonate Tautomerase
MW290_RS29430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MW290_RS29435	COG0321	lipoyl(octanoyl) transferase activity
MW290_RS29445	COG2921	Belongs to the UPF0250 family
MW290_RS29455	COG1686	Belongs to the peptidase S11 family
MW290_RS29520	COG1981	membrane
MW290_RS29530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MW290_RS29535	COG1702	phosphate starvation-inducible protein PhoH
MW290_RS29545	COG2197	response regulator
MW290_RS29550	COG0632	four-way junction helicase activity
MW290_RS29575	COG0583	DNA-binding transcription factor activity
MW290_RS29605	COG2255	four-way junction helicase activity
MW290_RS29650	COG1881	PFAM PEBP family protein
MW290_RS29675	COG1522	sequence-specific DNA binding
MW290_RS29695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MW290_RS29705	COG0183	Belongs to the thiolase family
MW290_RS29710	COG1414	Transcriptional regulator
MW290_RS29715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MW290_RS29750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MW290_RS29760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MW290_RS29770	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MW290_RS29775	COG0735	belongs to the Fur family
MW290_RS29780	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MW290_RS29785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MW290_RS29800	COG0495	leucyl-tRNA aminoacylation
MW290_RS29815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MW290_RS29820	COG1546	Belongs to the CinA family
MW290_RS29825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MW290_RS29865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MW290_RS29870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MW290_RS29875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MW290_RS29880	COG3178	'Phosphotransferase
MW290_RS29890	COG0584	glycerophosphoryl diester phosphodiesterase
MW290_RS29895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MW290_RS29900	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MW290_RS29930	COG2267	carboxylic ester hydrolase activity
MW290_RS29935	COG3800	Transcriptional regulator
MW290_RS29935	COG1396	sequence-specific DNA binding
MW290_RS29950	COG1024	Enoyl-CoA hydratase
MW290_RS29965	COG4977	sequence-specific DNA binding
MW290_RS29970	COG2814	Major facilitator Superfamily
MW290_RS29985	COG3162	membrane
MW290_RS30015	COG1764	response to oxidative stress
MW290_RS30030	COG4989	oxidoreductase activity
MW290_RS30035	COG0515	serine threonine protein kinase
MW290_RS30080	COG1522	sequence-specific DNA binding
MW290_RS30095	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
MW290_RS30105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MW290_RS30110	COG1560	Kdo2-lipid A biosynthetic process
MW290_RS30120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MW290_RS30125	COG3647	Membrane
MW290_RS30130	COG3214	Protein conserved in bacteria
MW290_RS30150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MW290_RS30185	COG3070	regulator of competence-specific genes
MW290_RS30195	COG0583	DNA-binding transcription factor activity
MW290_RS30200	COG0741	lytic transglycosylase activity
MW290_RS30210	COG0617	tRNA 3'-terminal CCA addition
MW290_RS30235	COG0037	tRNA processing
MW290_RS30250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MW290_RS30255	COG1573	uracil-dna glycosylase
MW290_RS30270	COG2027	D-alanyl-D-alanine carboxypeptidase
MW290_RS30280	COG0009	L-threonylcarbamoyladenylate synthase
MW290_RS30285	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MW290_RS30290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MW290_RS30305	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MW290_RS30320	COG0469	pyruvate kinase activity
MW290_RS30325	COG0281	malic enzyme
MW290_RS30325	COG0280	phosphate acetyltransferase
MW290_RS30330	COG0126	phosphoglycerate kinase activity
MW290_RS30350	COG0501	Belongs to the peptidase M48B family
MW290_RS30355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MW290_RS30360	COG0242	peptide deformylase activity
MW290_RS30370	COG0758	DNA mediated transformation
MW290_RS30375	COG2922	Belongs to the Smg family
MW290_RS30385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MW290_RS30390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MW290_RS30395	COG1862	Preprotein translocase
MW290_RS30405	COG0203	ribosomal protein L17
MW290_RS30410	COG0202	RNA polymerase activity
MW290_RS30415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MW290_RS30420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MW290_RS30425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MW290_RS30430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MW290_RS30440	COG0201	protein transport
MW290_RS30445	COG0200	Binds to the 23S rRNA
MW290_RS30450	COG1841	ribosomal large subunit assembly
MW290_RS30455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MW290_RS30460	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MW290_RS30465	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MW290_RS30470	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MW290_RS30475	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MW290_RS30480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MW290_RS30485	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MW290_RS30490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MW290_RS30495	COG0678	peroxiredoxin activity
MW290_RS30500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MW290_RS30505	COG0255	Belongs to the universal ribosomal protein uL29 family
MW290_RS30510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MW290_RS30515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MW290_RS30520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MW290_RS30525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MW290_RS30530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MW290_RS30535	COG0089	rRNA binding
MW290_RS30540	COG0088	Forms part of the polypeptide exit tunnel
MW290_RS30545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MW290_RS30550	COG0051	transcription antitermination factor activity, RNA binding
MW290_RS30555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MW290_RS30560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MW290_RS30565	COG0049	tRNA binding
MW290_RS30570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MW290_RS30580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MW290_RS30585	COG0085	RNA polymerase activity
MW290_RS30590	COG0222	ribosome binding
MW290_RS30595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MW290_RS30600	COG0081	regulation of translation
MW290_RS30605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MW290_RS30625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MW290_RS30645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MW290_RS30650	COG0134	indole-3-glycerol-phosphate synthase activity
MW290_RS30655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MW290_RS30665	COG0512	Glutamine amidotransferase of anthranilate synthase
MW290_RS30675	COG0210	DNA helicase
MW290_RS30685	COG2972	Histidine kinase
MW290_RS30690	COG2353	YceI-like domain
MW290_RS30700	COG3038	cytochrome b561
MW290_RS30715	COG0697	spore germination
MW290_RS30720	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MW290_RS30720	COG0506	proline dehydrogenase activity
MW290_RS30720	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
MW290_RS30725	COG0583	DNA-binding transcription factor activity
MW290_RS30740	COG0010	Belongs to the arginase family
MW290_RS30755	COG1522	sequence-specific DNA binding
MW290_RS30770	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MW290_RS30780	COG2967	ApaG domain
MW290_RS30795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MW290_RS30815	COG0546	phosphoglycolate phosphatase activity
MW290_RS30820	COG0583	DNA-binding transcription factor activity
MW290_RS30840	COG2301	Belongs to the HpcH HpaI aldolase family
MW290_RS30845	COG2079	MmgE PrpD family protein
MW290_RS30855	COG1960	acyl-CoA dehydrogenase activity
MW290_RS30860	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
MW290_RS30880	COG0179	Fumarylacetoacetate (FAA) hydrolase
MW290_RS30885	COG3791	Glutathione-dependent formaldehyde-activating
MW290_RS30890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MW290_RS30895	COG1027	Aspartate ammonia-lyase
MW290_RS30905	COG0765	amino acid transport
MW290_RS30910	COG4598	ABC transporter
MW290_RS30930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MW290_RS30935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MW290_RS30945	COG1704	LemA family
MW290_RS30965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MW290_RS30970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MW290_RS30975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MW290_RS30980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MW290_RS30985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MW290_RS30990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MW290_RS31000	COG0356	it plays a direct role in the translocation of protons across the membrane
MW290_RS31040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MW290_RS31050	COG0384	phenazine biosynthesis protein PhzF
MW290_RS31055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MW290_RS31060	COG1794	racemase activity, acting on amino acids and derivatives
MW290_RS31065	COG0697	spore germination
MW290_RS31085	COG0488	(ABC) transporter
MW290_RS31090	COG0737	Belongs to the 5'-nucleotidase family
MW290_RS31100	COG2974	May be involved in recombination
MW290_RS31115	COG4771	TonB-dependent receptor
MW290_RS31120	COG1739	Uncharacterized protein family UPF0029
MW290_RS31125	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MW290_RS31135	COG0189	ligase activity
MW290_RS31140	COG3135	benzoate transporter
MW290_RS31145	COG3158	transport of potassium into the cell
MW290_RS31160	COG0004	ammonium transporteR
MW290_RS31200	COG0646	methionine synthase
MW290_RS31200	COG1410	methionine synthase
MW290_RS31225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MW290_RS31260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MW290_RS31265	COG0697	spore germination
MW290_RS31275	COG3237	CsbD-like
MW290_RS31290	COG0395	ABC-type sugar transport system, permease component
MW290_RS31305	COG3842	ATPase activity
MW290_RS31320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MW290_RS31330	COG0612	Peptidase, M16
MW290_RS31335	COG0431	NADPH-dependent FMN reductase
MW290_RS31340	COG2204	response regulator
MW290_RS31345	COG5002	protein histidine kinase activity
MW290_RS31350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MW290_RS31395	COG2175	clavaminate synthase activity
MW290_RS31405	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MW290_RS31410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MW290_RS31455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MW290_RS31465	COG4208	sulfate ABC transporter
MW290_RS31470	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MW290_RS31490	COG0121	glutamine amidotransferase
MW290_RS31500	COG0644	oxidoreductase
MW290_RS31510	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MW290_RS31515	COG0583	DNA-binding transcription factor activity
MW290_RS31530	COG0018	arginyl-trna synthetase
MW290_RS31545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MW290_RS31550	COG1137	ATPase activity
MW290_RS31555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MW290_RS31565	COG4302	ethanolamine ammonia-lyase activity
MW290_RS31570	COG4303	Ethanolamine ammonia lyase large subunit
MW290_RS31575	COG1113	amino acid transport
MW290_RS31590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MW290_RS31595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MW290_RS31600	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS31625	COG0482	sulfurtransferase activity
MW290_RS31630	COG0583	DNA-binding transcription factor activity
MW290_RS31645	COG0343	queuine tRNA-ribosyltransferase activity
MW290_RS31650	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MW290_RS31655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MW290_RS31665	COG0783	Belongs to the Dps family
MW290_RS31670	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MW290_RS31680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MW290_RS31705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MW290_RS31710	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS31780	COG2823	Periplasmic or secreted lipoprotein
MW290_RS31785	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MW290_RS31795	COG0792	nuclease activity
MW290_RS31805	COG0312	modulator of DNA gyrase
MW290_RS31810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MW290_RS31830	COG3181	Tripartite tricarboxylate transporter family receptor
MW290_RS31835	COG0318	PFAM AMP-dependent synthetase and ligase
MW290_RS31850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MW290_RS31855	COG1024	Enoyl-CoA hydratase
MW290_RS31860	COG1960	acyl-CoA dehydrogenase activity
MW290_RS31865	COG1960	acyl-CoA dehydrogenase activity
MW290_RS31870	COG0183	Belongs to the thiolase family
MW290_RS31880	COG0583	DNA-binding transcription factor activity
MW290_RS31895	COG2096	Adenosyltransferase
MW290_RS31900	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MW290_RS31905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MW290_RS31910	COG0277	FAD linked oxidase domain protein
MW290_RS31920	COG2719	SpoVR family
MW290_RS31925	COG2718	Belongs to the UPF0229 family
MW290_RS31930	COG2766	serine protein kinase
MW290_RS31935	COG1475	DNA binding
MW290_RS31945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MW290_RS31955	COG1192	Involved in chromosome partitioning
MW290_RS31960	COG0587	DNA-directed DNA polymerase activity
MW290_RS31980	COG0357	Ribosomal RNA small subunit methyltransferase G
MW290_RS31985	COG0445	tRNA wobble uridine modification
MW290_RS32015	COG2197	response regulator
MW290_RS32025	COG1668	transmembrane transport
MW290_RS32030	COG4555	ABC transporter
MW290_RS32050	COG1881	PFAM PEBP family protein
MW290_RS32070	COG4251	negative regulation of phosphorylation
MW290_RS32075	COG2095	MarC family integral membrane protein
MW290_RS32085	COG0724	RNA recognition motif
MW290_RS32090	COG4221	oxidoreductase activity
MW290_RS32100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MW290_RS32105	COG0517	IMP dehydrogenase activity
MW290_RS32105	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MW290_RS32120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MW290_RS32125	COG0706	membrane insertase activity
MW290_RS32130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MW290_RS32140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MW290_RS32245	COG4974	Belongs to the 'phage' integrase family
MW290_RS32270	COG5002	protein histidine kinase activity
MW290_RS32270	COG5001	Diguanylate cyclase
MW290_RS32270	COG3447	MASE1 domain protein
MW290_RS32285	COG4974	Belongs to the 'phage' integrase family
MW290_RS32310	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MW290_RS32330	COG1192	Involved in chromosome partitioning
MW290_RS32375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MW290_RS32410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MW290_RS32415	COG1017	nitric oxide dioxygenase activity
MW290_RS32415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MW290_RS32420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MW290_RS32430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MW290_RS32475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MW290_RS32515	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MW290_RS32515	COG2111	Na H antiporter
MW290_RS32520	COG2111	Na H antiporter
MW290_RS32530	COG0651	ATP synthesis coupled electron transport
MW290_RS32535	COG1863	multisubunit Na H antiporter MnhE subunit
MW290_RS32545	COG1320	monovalent cation:proton antiporter activity
MW290_RS32570	COG2205	protein histidine kinase activity
MW290_RS32570	COG0784	Response regulator, receiver
MW290_RS32575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MW290_RS32630	COG1917	Cupin 2, conserved barrel domain protein
MW290_RS32630	COG2169	Transcriptional regulator
MW290_RS32635	COG1484	DNA-dependent DNA replication
MW290_RS32665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MW290_RS32680	COG0517	IMP dehydrogenase activity
MW290_RS32680	COG0617	tRNA 3'-terminal CCA addition
MW290_RS32680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MW290_RS32685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MW290_RS32720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MW290_RS32725	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MW290_RS32735	COG1752	Esterase of the alpha-beta hydrolase superfamily
MW290_RS32805	COG0789	Transcriptional regulator
MW290_RS32810	COG1742	UPF0060 membrane protein
MW290_RS32825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MW290_RS32830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MW290_RS32835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MW290_RS32865	COG0784	Response regulator, receiver
MW290_RS32865	COG5002	protein histidine kinase activity
MW290_RS32960	COG3344	reverse transcriptase