locus-tag	class	description
HC341_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC341_RS00010	COG0592	DNA-directed DNA polymerase activity
HC341_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC341_RS00020	COG0187	DNA topoisomerase II activity
HC341_RS00030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HC341_RS00035	COG0751	glycine-tRNA ligase activity
HC341_RS00045	COG0482	sulfurtransferase activity
HC341_RS00050	COG0425	Belongs to the sulfur carrier protein TusA family
HC341_RS00055	COG0174	glutamine synthetase
HC341_RS00065	COG3852	Histidine kinase
HC341_RS00070	COG2204	response regulator
HC341_RS00075	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS00080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC341_RS00085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC341_RS00090	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HC341_RS00095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC341_RS00100	COG4942	peptidase
HC341_RS00105	COG0793	Belongs to the peptidase S41A family
HC341_RS00135	COG1946	Acyl-CoA thioesterase
HC341_RS00140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HC341_RS00150	COG2226	methyltransferase
HC341_RS00160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HC341_RS00165	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HC341_RS00170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HC341_RS00180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC341_RS00200	COG0165	Argininosuccinate lyase
HC341_RS00205	COG2972	Histidine kinase
HC341_RS00205	COG0745	RESPONSE REGULATOR receiver
HC341_RS00215	COG0181	hydroxymethylbilane synthase activity
HC341_RS00220	COG1587	Uroporphyrinogen-III synthase
HC341_RS00225	COG2959	enzyme of heme biosynthesis
HC341_RS00240	COG0281	malic enzyme
HC341_RS00240	COG0280	phosphate acetyltransferase
HC341_RS00245	COG0596	Alpha beta hydrolase
HC341_RS00250	COG2902	Dehydrogenase
HC341_RS00260	COG2267	carboxylic ester hydrolase activity
HC341_RS00265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC341_RS00270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC341_RS00275	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC341_RS00280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HC341_RS00310	COG0009	L-threonylcarbamoyladenylate synthase
HC341_RS00320	COG2922	Belongs to the Smg family
HC341_RS00325	COG0758	DNA mediated transformation
HC341_RS00335	COG0242	peptide deformylase activity
HC341_RS00340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC341_RS00355	COG5000	phosphorelay sensor kinase activity
HC341_RS00360	COG2204	response regulator
HC341_RS00365	COG0569	domain protein
HC341_RS00370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC341_RS00390	COG1490	D-aminoacyl-tRNA deacylase activity
HC341_RS00395	COG0131	Imidazoleglycerol-phosphate dehydratase
HC341_RS00400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC341_RS00405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HC341_RS00410	COG0107	imidazoleglycerol-phosphate synthase activity
HC341_RS00415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC341_RS00420	COG0140	phosphoribosyl-ATP diphosphatase activity
HC341_RS00425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC341_RS00430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC341_RS00435	COG0805	protein transport
HC341_RS00460	COG0604	alcohol dehydrogenase
HC341_RS00470	COG0372	Belongs to the citrate synthase family
HC341_RS00475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC341_RS00480	COG2828	Protein conserved in bacteria
HC341_RS00490	COG1764	response to oxidative stress
HC341_RS00515	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HC341_RS00520	COG1012	belongs to the aldehyde dehydrogenase family
HC341_RS00525	COG1309	transcriptional regulator
HC341_RS00540	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HC341_RS00550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HC341_RS00565	COG4206	TonB-dependent receptor
HC341_RS00585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC341_RS00590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC341_RS00595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HC341_RS00610	COG1492	cobalamin metabolic process
HC341_RS00620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC341_RS00635	COG1166	arginine decarboxylase activity
HC341_RS00640	COG2084	Dehydrogenase
HC341_RS00655	COG0018	arginyl-trna synthetase
HC341_RS00670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC341_RS00680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HC341_RS00695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC341_RS00700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC341_RS00700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC341_RS00705	COG3001	Fructosamine kinase
HC341_RS00720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HC341_RS00725	COG5001	Diguanylate cyclase
HC341_RS00725	COG3447	MASE1 domain protein
HC341_RS00725	COG5002	protein histidine kinase activity
HC341_RS00730	COG0543	2 iron, 2 sulfur cluster binding
HC341_RS00730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC341_RS00735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC341_RS00740	COG4774	siderophore transport
HC341_RS00755	COG1196	nuclear chromosome segregation
HC341_RS00800	COG2161	toxin-antitoxin pair type II binding
HC341_RS00815	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HC341_RS00820	COG0732	type I restriction modification DNA specificity domain
HC341_RS00870	COG0708	Exodeoxyribonuclease III
HC341_RS00875	COG0537	adenosine 5'-monophosphoramidase activity
HC341_RS00905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC341_RS00955	COG1309	transcriptional regulator
HC341_RS00975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC341_RS00985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC341_RS00990	COG0494	nUDIX hydrolase
HC341_RS00995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HC341_RS01000	COG0493	'glutamate synthase
HC341_RS01005	COG0067	glutamate synthase
HC341_RS01005	COG0069	glutamate synthase activity
HC341_RS01005	COG0070	glutamate synthase
HC341_RS01015	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HC341_RS01020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HC341_RS01025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC341_RS01065	COG0372	Belongs to the citrate synthase family
HC341_RS01070	COG0254	rRNA binding
HC341_RS01085	COG0277	FAD linked oxidase domain protein
HC341_RS01090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC341_RS01105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC341_RS01110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC341_RS01115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC341_RS01120	COG1561	YicC-like family, N-terminal region
HC341_RS01125	COG0194	GDP metabolic process
HC341_RS01130	COG1758	RNA polymerase activity
HC341_RS01135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC341_RS01150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC341_RS01155	COG3161	chorismate lyase activity
HC341_RS01160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HC341_RS01165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC341_RS01170	COG3707	response regulator
HC341_RS01175	COG1116	anion transmembrane transporter activity
HC341_RS01175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC341_RS01180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC341_RS01185	COG1116	anion transmembrane transporter activity
HC341_RS01190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC341_RS01200	COG0243	molybdopterin cofactor binding
HC341_RS01205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC341_RS01205	COG1648	precorrin-2 dehydrogenase activity
HC341_RS01260	COG2433	Pfam Transposase IS66
HC341_RS01290	COG0501	Belongs to the peptidase M48B family
HC341_RS01300	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS01325	COG0513	Belongs to the DEAD box helicase family
HC341_RS01335	COG1686	Belongs to the peptidase S11 family
HC341_RS01355	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HC341_RS01360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC341_RS01365	COG2183	response to ionizing radiation
HC341_RS01390	COG0739	heme binding
HC341_RS01420	COG0006	proline dipeptidase activity
HC341_RS01425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC341_RS01430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC341_RS01435	COG2204	response regulator
HC341_RS01435	COG5564	TIM-barrel signal transduction protein
HC341_RS01465	COG2433	Pfam Transposase IS66
HC341_RS01485	COG5441	Belongs to the UPF0261 family
HC341_RS01490	COG5564	TIM-barrel signal transduction protein
HC341_RS01500	COG2268	Band 7 protein
HC341_RS01505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC341_RS01520	COG1178	ABC-type Fe3 transport system permease component
HC341_RS01525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC341_RS01530	COG0509	glycine decarboxylation via glycine cleavage system
HC341_RS01535	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC341_RS01540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC341_RS01545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC341_RS01550	COG1960	acyl-CoA dehydrogenase activity
HC341_RS01555	COG0436	Aminotransferase
HC341_RS01565	COG0683	leucine binding
HC341_RS01595	COG0741	lytic transglycosylase activity
HC341_RS01605	COG2096	Adenosyltransferase
HC341_RS01615	COG1793	dna ligase
HC341_RS01630	COG1201	RNA secondary structure unwinding
HC341_RS01645	COG0583	DNA-binding transcription factor activity
HC341_RS01655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC341_RS01660	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HC341_RS01665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HC341_RS01685	COG1522	sequence-specific DNA binding
HC341_RS01690	COG1346	cytolysis
HC341_RS01705	COG0494	nUDIX hydrolase
HC341_RS01735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC341_RS01740	COG0316	Belongs to the HesB IscA family
HC341_RS01745	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HC341_RS01750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC341_RS01780	COG1362	aminopeptidase activity
HC341_RS01790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HC341_RS01805	COG2135	peptidase activity
HC341_RS01810	COG0584	glycerophosphoryl diester phosphodiesterase
HC341_RS01855	COG0659	secondary active sulfate transmembrane transporter activity
HC341_RS01860	COG0788	formyltetrahydrofolate deformylase activity
HC341_RS01875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC341_RS01875	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC341_RS01890	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC341_RS01895	COG2218	PFAM glutamate synthase alpha subunit domain protein
HC341_RS01900	COG0069	glutamate synthase activity
HC341_RS01935	COG1597	lipid kinase activity
HC341_RS01950	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HC341_RS01955	COG2943	transferase activity, transferring hexosyl groups
HC341_RS01965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC341_RS01970	COG2040	homocysteine
HC341_RS01980	COG1309	transcriptional regulator
HC341_RS01985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC341_RS01990	COG0583	DNA-binding transcription factor activity
HC341_RS02000	COG2311	Membrane
HC341_RS02005	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC341_RS02030	COG0583	DNA-binding transcription factor activity
HC341_RS02035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC341_RS02040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC341_RS02065	COG0756	dUTP diphosphatase activity
HC341_RS02095	COG1525	nuclease
HC341_RS02115	COG3568	Endonuclease Exonuclease Phosphatase
HC341_RS02115	COG1555	photosystem II stabilization
HC341_RS02135	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC341_RS02140	COG2135	peptidase activity
HC341_RS02195	COG0582	viral genome integration into host DNA
HC341_RS02205	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HC341_RS02210	COG0602	queuosine metabolic process
HC341_RS02225	COG0823	Involved in the tonB-independent uptake of proteins
HC341_RS02245	COG0824	Thioesterase
HC341_RS02250	COG2204	response regulator
HC341_RS02260	COG2205	protein histidine kinase activity
HC341_RS02265	COG2255	four-way junction helicase activity
HC341_RS02270	COG0632	four-way junction helicase activity
HC341_RS02275	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HC341_RS02280	COG0217	transcriptional regulatory protein
HC341_RS02300	COG4177	L-phenylalanine transmembrane transporter activity
HC341_RS02320	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS02335	COG0183	Belongs to the thiolase family
HC341_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS02370	COG2716	regulation of RNA biosynthetic process
HC341_RS02375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC341_RS02380	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HC341_RS02390	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS02405	COG0129	dihydroxy-acid dehydratase activity
HC341_RS02410	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HC341_RS02420	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC341_RS02435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC341_RS02440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HC341_RS02475	COG0824	Thioesterase
HC341_RS02505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC341_RS02510	COG0540	Belongs to the ATCase OTCase family
HC341_RS02515	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HC341_RS02520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC341_RS02525	COG1678	Uncharacterized ACR, COG1678
HC341_RS02560	COG0840	transmembrane signaling receptor activity
HC341_RS02570	COG0643	Histidine kinase
HC341_RS02570	COG0784	Response regulator, receiver
HC341_RS02570	COG2198	Histidine kinase
HC341_RS02575	COG2201	protein-glutamate methylesterase activity
HC341_RS02585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC341_RS02590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HC341_RS02595	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HC341_RS02600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC341_RS02615	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC341_RS02620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC341_RS02625	COG0126	phosphoglycerate kinase activity
HC341_RS02630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC341_RS02675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC341_RS02685	COG1022	Amp-dependent synthetase and ligase
HC341_RS02690	COG4221	oxidoreductase activity
HC341_RS02695	COG1335	isochorismatase
HC341_RS02705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC341_RS02780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC341_RS02795	COG3665	Urea carboxylase-associated protein
HC341_RS02800	COG0439	Biotin carboxylase
HC341_RS02825	COG0625	glutathione transferase activity
HC341_RS02845	COG0346	lactoylglutathione lyase activity
HC341_RS02860	COG0505	Belongs to the CarA family
HC341_RS02865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC341_RS02870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC341_RS02885	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HC341_RS02895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC341_RS02900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC341_RS02905	COG0149	triose-phosphate isomerase activity
HC341_RS02920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC341_RS02925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC341_RS02930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC341_RS02935	COG0649	NAD binding
HC341_RS02950	COG1034	ATP synthesis coupled electron transport
HC341_RS02950	COG1034	ATP synthesis coupled electron transport
HC341_RS02955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HC341_RS02960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC341_RS02970	COG0713	ATP synthesis coupled electron transport
HC341_RS02985	COG1007	ATP synthesis coupled electron transport
HC341_RS03010	COG0577	efflux transmembrane transporter activity
HC341_RS03010	COG1136	(ABC) transporter
HC341_RS03045	COG0385	Bile acid
HC341_RS03055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC341_RS03060	COG0183	Belongs to the thiolase family
HC341_RS03065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC341_RS03090	COG2205	protein histidine kinase activity
HC341_RS03095	COG0745	RESPONSE REGULATOR receiver
HC341_RS03115	COG3038	cytochrome b561
HC341_RS03120	COG2353	YceI-like domain
HC341_RS03125	COG0842	Transport permease protein
HC341_RS03130	COG1131	(ABC) transporter
HC341_RS03135	COG0778	Nitroreductase
HC341_RS03140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC341_RS03145	COG1335	isochorismatase
HC341_RS03160	COG3321	synthase
HC341_RS03160	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS03160	COG0604	alcohol dehydrogenase
HC341_RS03170	COG2200	EAL domain
HC341_RS03175	COG3706	GGDEF domain
HC341_RS03180	COG1643	Atp-dependent helicase
HC341_RS03205	COG0488	(ABC) transporter
HC341_RS03210	COG0189	ligase activity
HC341_RS03215	COG4067	protein conserved in archaea
HC341_RS03215	COG0189	ligase activity
HC341_RS03220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC341_RS03225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC341_RS03230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC341_RS03230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC341_RS03250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC341_RS03260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC341_RS03270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC341_RS03295	COG0011	TIGRFAM Protein of
HC341_RS03300	COG2733	membrane
HC341_RS03310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC341_RS03315	COG1121	(ABC) transporter
HC341_RS03320	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC341_RS03325	COG0346	lactoylglutathione lyase activity
HC341_RS03350	COG2738	Putative neutral zinc metallopeptidase
HC341_RS03375	COG2239	Acts as a magnesium transporter
HC341_RS03385	COG1309	transcriptional regulator
HC341_RS03390	COG1024	Enoyl-CoA hydratase
HC341_RS03400	COG2030	dehydratase
HC341_RS03435	COG1309	transcriptional regulator
HC341_RS03440	COG2918	glutathione biosynthetic process
HC341_RS03445	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS03445	COG3321	synthase
HC341_RS03445	COG0604	alcohol dehydrogenase
HC341_RS03460	COG0473	3-isopropylmalate dehydrogenase activity
HC341_RS03490	COG0436	Aminotransferase
HC341_RS03495	COG1024	Enoyl-CoA hydratase
HC341_RS03500	COG1024	Enoyl-CoA hydratase
HC341_RS03505	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS03510	COG1832	CoA-binding protein
HC341_RS03530	COG1309	transcriptional regulator
HC341_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS03540	COG0709	Synthesizes selenophosphate from selenide and ATP
HC341_RS03550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HC341_RS03555	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HC341_RS03560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HC341_RS03565	COG3639	organic phosphonate transmembrane transporter activity
HC341_RS03575	COG0517	IMP dehydrogenase activity
HC341_RS03590	COG2234	aminopeptidase activity
HC341_RS03595	COG0228	four-way junction DNA binding
HC341_RS03600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC341_RS03605	COG0336	Belongs to the RNA methyltransferase TrmD family
HC341_RS03610	COG0335	large ribosomal subunit rRNA binding
HC341_RS03640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HC341_RS03655	COG1454	alcohol dehydrogenase
HC341_RS03660	COG0560	Phosphoserine phosphatase
HC341_RS03660	COG3830	Belongs to the UPF0237 family
HC341_RS03675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC341_RS03680	COG0028	Belongs to the TPP enzyme family
HC341_RS03690	COG0326	Molecular chaperone. Has ATPase activity
HC341_RS03695	COG0850	regulation of cytokinetic process
HC341_RS03700	COG2894	cell division
HC341_RS03705	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HC341_RS03710	COG0741	lytic transglycosylase activity
HC341_RS03710	COG1388	LysM domain
HC341_RS03715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC341_RS03725	COG0328	RNA-DNA hybrid ribonuclease activity
HC341_RS03735	COG1011	Hydrolase
HC341_RS03790	COG4227	nucleotidyltransferase activity
HC341_RS03810	COG2003	Belongs to the UPF0758 family
HC341_RS03820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC341_RS03830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC341_RS03835	COG3842	ATPase activity
HC341_RS03865	COG1116	anion transmembrane transporter activity
HC341_RS03865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC341_RS03950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC341_RS03990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC341_RS04005	COG2353	YceI-like domain
HC341_RS04020	COG3311	Transcriptional regulator
HC341_RS04035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC341_RS04040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HC341_RS04065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HC341_RS04080	COG1271	oxidase subunit
HC341_RS04085	COG1294	oxidase, subunit
HC341_RS04165	COG0277	FAD linked oxidase domain protein
HC341_RS04165	COG0247	lactate metabolic process
HC341_RS04170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HC341_RS04200	COG2433	Pfam Transposase IS66
HC341_RS04260	COG1484	DNA-dependent DNA replication
HC341_RS04265	COG4584	PFAM Integrase catalytic
HC341_RS04300	COG1192	Involved in chromosome partitioning
HC341_RS04310	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC341_RS04315	COG2070	2-Nitropropane dioxygenase
HC341_RS04345	COG0251	oxidation-reduction process
HC341_RS04350	COG2826	transposase and inactivated derivatives, IS30 family
HC341_RS04360	COG0765	amino acid transport
HC341_RS04365	COG1126	abc transporter atp-binding protein
HC341_RS04375	COG0784	Response regulator, receiver
HC341_RS04375	COG4191	Histidine kinase
HC341_RS04385	COG0596	Alpha beta hydrolase
HC341_RS04400	COG0523	cobalamin synthesis protein
HC341_RS04430	COG2610	gluconate transmembrane transporter activity
HC341_RS04500	COG2267	carboxylic ester hydrolase activity
HC341_RS04510	COG1309	transcriptional regulator
HC341_RS04535	COG1126	abc transporter atp-binding protein
HC341_RS04540	COG0765	amino acid transport
HC341_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC341_RS04565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC341_RS04585	COG3088	subunit of a heme lyase
HC341_RS04590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC341_RS04600	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HC341_RS04620	COG4133	protoheme IX ABC transporter activity
HC341_RS04625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC341_RS04630	COG2267	carboxylic ester hydrolase activity
HC341_RS04670	COG0779	Required for maturation of 30S ribosomal subunits
HC341_RS04675	COG0195	Participates in both transcription termination and antitermination
HC341_RS04675	COG2251	uridine kinase activity
HC341_RS04680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC341_RS04685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC341_RS04690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC341_RS04695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HC341_RS04700	COG1185	polyribonucleotide nucleotidyltransferase activity
HC341_RS04710	COG0429	hydrolase of the alpha beta-hydrolase fold
HC341_RS04715	COG5002	protein histidine kinase activity
HC341_RS04725	COG0745	RESPONSE REGULATOR receiver
HC341_RS04730	COG1024	Enoyl-CoA hydratase
HC341_RS04765	COG1022	Amp-dependent synthetase and ligase
HC341_RS04770	COG1960	acyl-CoA dehydrogenase activity
HC341_RS04795	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS04810	COG0142	geranyltranstransferase activity
HC341_RS04815	COG1722	exodeoxyribonuclease VII activity
HC341_RS04830	COG0501	Belongs to the peptidase M48B family
HC341_RS04835	COG5001	Diguanylate cyclase
HC341_RS04835	COG3300	MHYT domain
HC341_RS04845	COG1509	lysine 2,3-aminomutase activity
HC341_RS04850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC341_RS04855	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HC341_RS04860	COG2719	SpoVR family
HC341_RS04865	COG2718	Belongs to the UPF0229 family
HC341_RS04870	COG2766	serine protein kinase
HC341_RS04875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC341_RS04880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC341_RS04885	COG5007	Belongs to the BolA IbaG family
HC341_RS04890	COG2350	Protein conserved in bacteria
HC341_RS04895	COG0009	L-threonylcarbamoyladenylate synthase
HC341_RS04900	COG0180	Tryptophanyl-tRNA synthetase
HC341_RS04910	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC341_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS04940	COG1562	ergosterol biosynthetic process
HC341_RS04950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC341_RS04955	COG0402	S-adenosylhomocysteine deaminase activity
HC341_RS04960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HC341_RS04985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HC341_RS04990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC341_RS05000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC341_RS05005	COG0287	Prephenate dehydrogenase
HC341_RS05010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC341_RS05025	COG0776	regulation of translation
HC341_RS05035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HC341_RS05040	COG0284	orotidine-5'-phosphate decarboxylase activity
HC341_RS05060	COG0573	inorganic phosphate transmembrane transporter activity
HC341_RS05065	COG0581	inorganic phosphate transmembrane transporter activity
HC341_RS05070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC341_RS05075	COG0704	Plays a role in the regulation of phosphate uptake
HC341_RS05095	COG0745	RESPONSE REGULATOR receiver
HC341_RS05100	COG3639	organic phosphonate transmembrane transporter activity
HC341_RS05105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HC341_RS05115	COG0438	transferase activity, transferring glycosyl groups
HC341_RS05125	COG3842	ATPase activity
HC341_RS05135	COG1840	ABC-type Fe3 transport system, periplasmic component
HC341_RS05150	COG1178	ABC-type Fe3 transport system permease component
HC341_RS05185	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS05190	COG0183	Belongs to the thiolase family
HC341_RS05195	COG1024	Enoyl-CoA hydratase
HC341_RS05195	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC341_RS05205	COG0702	epimerase
HC341_RS05210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC341_RS05215	COG1024	Enoyl-CoA hydratase
HC341_RS05230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HC341_RS05235	COG2937	Belongs to the GPAT DAPAT family
HC341_RS05245	COG1309	transcriptional regulator
HC341_RS05280	COG0154	amidase activity
HC341_RS05310	COG2816	NAD+ diphosphatase activity
HC341_RS05325	COG0697	spore germination
HC341_RS05335	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HC341_RS05360	COG0688	phosphatidylethanolamine metabolic process
HC341_RS05365	COG1999	signal sequence binding
HC341_RS05375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC341_RS05380	COG2814	Major facilitator Superfamily
HC341_RS05385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HC341_RS05390	COG0066	3-isopropylmalate dehydratase activity
HC341_RS05395	COG0473	3-isopropylmalate dehydrogenase activity
HC341_RS05415	COG0135	phosphoribosylanthranilate isomerase activity
HC341_RS05420	COG0133	tryptophan synthase activity
HC341_RS05425	COG0159	tryptophan synthase activity
HC341_RS05430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC341_RS05435	COG0285	dihydrofolate synthase activity
HC341_RS05445	COG1286	toxin biosynthetic process
HC341_RS05460	COG2379	hydroxypyruvate reductase
HC341_RS05475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HC341_RS05480	COG3153	acetyltransferase
HC341_RS05480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC341_RS05485	COG0288	reversible hydration of carbon dioxide
HC341_RS05515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC341_RS05520	COG4660	Part of a membrane complex involved in electron transport
HC341_RS05530	COG4659	FMN binding
HC341_RS05540	COG4656	Part of a membrane complex involved in electron transport
HC341_RS05545	COG2878	Part of a membrane complex involved in electron transport
HC341_RS05555	COG4657	Part of a membrane complex involved in electron transport
HC341_RS05560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC341_RS05560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC341_RS05565	COG0116	Belongs to the methyltransferase superfamily
HC341_RS05565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC341_RS05580	COG0717	Belongs to the dCTP deaminase family
HC341_RS05595	COG5001	Diguanylate cyclase
HC341_RS05595	COG4251	negative regulation of phosphorylation
HC341_RS05595	COG3706	GGDEF domain
HC341_RS05595	COG2203	Gaf domain
HC341_RS05610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC341_RS05615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC341_RS05645	COG1959	2 iron, 2 sulfur cluster binding
HC341_RS05645	COG1295	ribonuclease BN
HC341_RS05650	COG1254	Belongs to the acylphosphatase family
HC341_RS05675	COG0746	molybdenum cofactor guanylyltransferase activity
HC341_RS05750	COG0437	4 iron, 4 sulfur cluster binding
HC341_RS05770	COG3243	poly(R)-hydroxyalkanoic acid synthase
HC341_RS05775	COG3174	membrane
HC341_RS05815	COG0745	RESPONSE REGULATOR receiver
HC341_RS05830	COG3706	GGDEF domain
HC341_RS05835	COG3683	transport system, periplasmic component
HC341_RS05860	COG3275	phosphorelay sensor kinase activity
HC341_RS05870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC341_RS05875	COG0156	8-amino-7-oxononanoate synthase activity
HC341_RS05880	COG2027	D-alanyl-D-alanine carboxypeptidase
HC341_RS05910	COG0121	glutamine amidotransferase
HC341_RS05920	COG3842	ATPase activity
HC341_RS05935	COG0651	ATP synthesis coupled electron transport
HC341_RS05940	COG0651	ATP synthesis coupled electron transport
HC341_RS05945	COG0651	ATP synthesis coupled electron transport
HC341_RS05960	COG1320	monovalent cation:proton antiporter activity
HC341_RS05975	COG0402	S-adenosylhomocysteine deaminase activity
HC341_RS05985	COG2239	Acts as a magnesium transporter
HC341_RS05990	COG0085	RNA polymerase activity
HC341_RS05995	COG1418	mRNA catabolic process
HC341_RS06005	COG1320	monovalent cation:proton antiporter activity
HC341_RS06010	COG2212	antiporter activity
HC341_RS06030	COG2111	Na H antiporter
HC341_RS06040	COG1830	Aldolase
HC341_RS06125	COG0477	Major facilitator Superfamily
HC341_RS06160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HC341_RS06180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC341_RS06190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC341_RS06195	COG1131	(ABC) transporter
HC341_RS06200	COG0842	Transport permease protein
HC341_RS06205	COG0842	Transport permease protein
HC341_RS06210	COG2217	Heavy metal translocating P-type atpase
HC341_RS06295	COG0723	plastoquinol--plastocyanin reductase activity
HC341_RS06330	COG0010	Belongs to the arginase family
HC341_RS06360	COG0765	amino acid transport
HC341_RS06385	COG3093	addiction module antidote protein HigA
HC341_RS06405	COG3311	Transcriptional regulator
HC341_RS06440	COG0840	transmembrane signaling receptor activity
HC341_RS06445	COG5001	Diguanylate cyclase
HC341_RS06450	COG0745	RESPONSE REGULATOR receiver
HC341_RS06460	COG5002	protein histidine kinase activity
HC341_RS06465	COG5002	protein histidine kinase activity
HC341_RS06480	COG2433	Pfam Transposase IS66
HC341_RS06500	COG3706	GGDEF domain
HC341_RS06515	COG1484	DNA-dependent DNA replication
HC341_RS06520	COG5002	protein histidine kinase activity
HC341_RS06520	COG5001	Diguanylate cyclase
HC341_RS06520	COG3447	MASE1 domain protein
HC341_RS06530	COG2363	Small membrane protein
HC341_RS06535	COG0784	Response regulator, receiver
HC341_RS06535	COG4191	Histidine kinase
HC341_RS06565	COG0640	Transcriptional regulator
HC341_RS06570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC341_RS06575	COG0798	PFAM Bile acid sodium symporter
HC341_RS06595	COG0431	NADPH-dependent FMN reductase
HC341_RS06605	COG0183	Belongs to the thiolase family
HC341_RS06610	COG1047	Peptidyl-prolyl cis-trans
HC341_RS06625	COG0437	4 iron, 4 sulfur cluster binding
HC341_RS06630	COG0243	molybdopterin cofactor binding
HC341_RS06645	COG4191	Histidine kinase
HC341_RS06650	COG2204	response regulator
HC341_RS06670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC341_RS06695	COG2059	Chromate
HC341_RS06700	COG3842	ATPase activity
HC341_RS06705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC341_RS06710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC341_RS06715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HC341_RS06720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC341_RS06730	COG0418	dihydroorotase activity
HC341_RS06755	COG0137	argininosuccinate synthase activity
HC341_RS06760	COG5001	Diguanylate cyclase
HC341_RS06760	COG5002	protein histidine kinase activity
HC341_RS06780	COG1960	acyl-CoA dehydrogenase activity
HC341_RS06785	COG0183	Belongs to the thiolase family
HC341_RS06795	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS06815	COG2267	carboxylic ester hydrolase activity
HC341_RS06835	COG1959	2 iron, 2 sulfur cluster binding
HC341_RS06840	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HC341_RS06845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC341_RS06855	COG1333	cytochrome c biogenesis protein
HC341_RS06860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC341_RS06875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC341_RS06875	COG2111	Na H antiporter
HC341_RS06880	COG0651	ATP synthesis coupled electron transport
HC341_RS06895	COG1320	monovalent cation:proton antiporter activity
HC341_RS06920	COG3278	Belongs to the heme-copper respiratory oxidase family
HC341_RS06935	COG2010	Cytochrome c
HC341_RS06955	COG2217	Heavy metal translocating P-type atpase
HC341_RS06960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC341_RS06965	COG2770	Histidine kinase
HC341_RS06965	COG2208	phosphoserine phosphatase activity
HC341_RS06980	COG2203	Gaf domain
HC341_RS06980	COG4251	negative regulation of phosphorylation
HC341_RS06980	COG5001	Diguanylate cyclase
HC341_RS06980	COG3706	GGDEF domain
HC341_RS07010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HC341_RS07030	COG0415	Belongs to the DNA photolyase family
HC341_RS07045	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC341_RS07090	COG2433	Pfam Transposase IS66
HC341_RS07095	COG0436	Aminotransferase
HC341_RS07115	COG2963	transposase activity
HC341_RS07150	COG2129	metallophosphoesterase
HC341_RS07175	COG3541	Predicted nucleotidyltransferase
HC341_RS07235	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC341_RS07245	COG2129	metallophosphoesterase
HC341_RS07255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC341_RS07345	COG0582	viral genome integration into host DNA
HC341_RS07370	COG2226	methyltransferase
HC341_RS07375	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HC341_RS07380	COG1074	ATP-dependent DNA helicase activity
HC341_RS07385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC341_RS07435	COG0436	Aminotransferase
HC341_RS07440	COG0556	nucleotide-excision repair
HC341_RS07445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC341_RS07455	COG1846	Transcriptional regulator
HC341_RS07460	COG1566	PFAM secretion protein HlyD family protein
HC341_RS07465	COG0477	Major facilitator Superfamily
HC341_RS07475	COG3453	Protein conserved in bacteria
HC341_RS07475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC341_RS07500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC341_RS07525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HC341_RS07550	COG2204	response regulator
HC341_RS07555	COG4191	Histidine kinase
HC341_RS07600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC341_RS07600	COG1116	anion transmembrane transporter activity
HC341_RS07615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC341_RS07635	COG1132	(ABC) transporter
HC341_RS07640	COG0037	tRNA processing
HC341_RS07655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HC341_RS07660	COG0343	queuine tRNA-ribosyltransferase activity
HC341_RS07665	COG1862	Preprotein translocase
HC341_RS07670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC341_RS07675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC341_RS07695	COG1309	transcriptional regulator
HC341_RS07710	COG0724	RNA recognition motif
HC341_RS07750	COG0316	Belongs to the HesB IscA family
HC341_RS07755	COG0105	UTP biosynthetic process
HC341_RS07760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC341_RS07765	COG3063	Type IV pilus biogenesis stability protein PilW
HC341_RS07775	COG0124	histidyl-tRNA synthetase
HC341_RS07780	COG2976	Protein conserved in bacteria
HC341_RS07800	COG0563	adenylate kinase activity
HC341_RS07810	COG0259	pyridoxamine-phosphate oxidase activity
HC341_RS07815	COG2814	Major facilitator Superfamily
HC341_RS07830	COG0842	Transport permease protein
HC341_RS07835	COG1131	(ABC) transporter
HC341_RS07845	COG0435	Glutathione S-transferase
HC341_RS07850	COG0739	heme binding
HC341_RS07855	COG1570	exodeoxyribonuclease VII activity
HC341_RS07865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC341_RS07865	COG0519	Catalyzes the synthesis of GMP from XMP
HC341_RS07875	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HC341_RS07890	COG1233	COG1233 Phytoene dehydrogenase and related
HC341_RS07905	COG1136	(ABC) transporter
HC341_RS07910	COG0523	cobalamin synthesis protein
HC341_RS07915	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC341_RS07915	COG1024	Enoyl-CoA hydratase
HC341_RS07920	COG0183	Belongs to the thiolase family
HC341_RS07925	COG1802	Transcriptional regulator
HC341_RS07935	COG1366	Belongs to the anti-sigma-factor antagonist family
HC341_RS07940	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HC341_RS07945	COG1116	anion transmembrane transporter activity
HC341_RS07950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC341_RS07955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC341_RS07955	COG1116	anion transmembrane transporter activity
HC341_RS07960	COG3707	response regulator
HC341_RS07965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC341_RS07970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC341_RS07975	COG1968	undecaprenyl-diphosphatase activity
HC341_RS07985	COG1408	metallophosphoesterase
HC341_RS08020	COG2951	lytic endotransglycosylase activity
HC341_RS08040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HC341_RS08060	COG1073	alpha beta
HC341_RS08080	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HC341_RS08085	COG0330	HflC and HflK could
HC341_RS08095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC341_RS08100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HC341_RS08105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC341_RS08115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC341_RS08120	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HC341_RS08125	COG2137	regulation of response to DNA damage stimulus
HC341_RS08130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC341_RS08135	COG0527	aspartate kinase activity
HC341_RS08140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC341_RS08165	COG3706	GGDEF domain
HC341_RS08175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC341_RS08180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC341_RS08185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC341_RS08190	COG1162	GTPase activity
HC341_RS08205	COG0247	lactate metabolic process
HC341_RS08210	COG0277	FAD linked oxidase domain protein
HC341_RS08215	COG0277	FAD linked oxidase domain protein
HC341_RS08225	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HC341_RS08250	COG0714	Associated with various cellular activities
HC341_RS08255	COG0745	RESPONSE REGULATOR receiver
HC341_RS08260	COG0739	heme binding
HC341_RS08270	COG2885	chlorophyll binding
HC341_RS08280	COG3300	MHYT domain
HC341_RS08280	COG5001	Diguanylate cyclase
HC341_RS08320	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC341_RS08325	COG0733	neurotransmitter:sodium symporter activity
HC341_RS08340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC341_RS08345	COG0735	belongs to the Fur family
HC341_RS08350	COG0497	DNA recombination
HC341_RS08355	COG1420	regulation of RNA biosynthetic process
HC341_RS08360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC341_RS08365	COG0443	Heat shock 70 kDa protein
HC341_RS08370	COG0484	heat shock protein binding
HC341_RS08375	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC341_RS08380	COG0697	spore germination
HC341_RS08385	COG0697	spore germination
HC341_RS08395	COG3706	GGDEF domain
HC341_RS08420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC341_RS08440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC341_RS08455	COG2433	Pfam Transposase IS66
HC341_RS08460	COG3436	PFAM IS66 Orf2 family protein
HC341_RS08480	COG2826	transposase and inactivated derivatives, IS30 family
HC341_RS08495	COG1487	ribonuclease activity
HC341_RS08505	COG1715	Restriction endonuclease
HC341_RS08520	COG0463	Glycosyl transferase, family 2
HC341_RS08565	COG4584	PFAM Integrase catalytic
HC341_RS08570	COG1484	DNA-dependent DNA replication
HC341_RS08585	COG1484	DNA-dependent DNA replication
HC341_RS08600	COG0640	Transcriptional regulator
HC341_RS08615	COG3118	belongs to the thioredoxin family
HC341_RS08620	COG0492	ferredoxin-NADP+ reductase activity
HC341_RS08625	COG0121	glutamine amidotransferase
HC341_RS08630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC341_RS08635	COG2814	Major facilitator Superfamily
HC341_RS08645	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HC341_RS08655	COG2353	YceI-like domain
HC341_RS08670	COG5001	Diguanylate cyclase
HC341_RS08670	COG3447	MASE1 domain protein
HC341_RS08670	COG5002	protein histidine kinase activity
HC341_RS08675	COG3706	GGDEF domain
HC341_RS08710	COG2135	peptidase activity
HC341_RS08730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC341_RS08735	COG1454	alcohol dehydrogenase
HC341_RS08745	COG2135	peptidase activity
HC341_RS08800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC341_RS08805	COG0656	L-ascorbic acid biosynthetic process
HC341_RS08830	COG3239	Fatty acid desaturase
HC341_RS08840	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC341_RS08890	COG1360	Flagellar Motor Protein
HC341_RS08905	COG2832	Protein of unknown function (DUF454)
HC341_RS08910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC341_RS08925	COG3706	GGDEF domain
HC341_RS08935	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HC341_RS08945	COG0583	DNA-binding transcription factor activity
HC341_RS08965	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HC341_RS08975	COG0471	metal ion transport
HC341_RS09015	COG1671	Belongs to the UPF0178 family
HC341_RS09035	COG1959	2 iron, 2 sulfur cluster binding
HC341_RS09040	COG5002	protein histidine kinase activity
HC341_RS09040	COG2176	DNA-directed DNA polymerase activity
HC341_RS09060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC341_RS09075	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC341_RS09085	COG3300	MHYT domain
HC341_RS09085	COG5001	Diguanylate cyclase
HC341_RS09095	COG2211	Major facilitator Superfamily
HC341_RS09110	COG2133	pyrroloquinoline quinone binding
HC341_RS09115	COG1966	Carbon starvation protein
HC341_RS09125	COG0003	Pfam Anion-transporting ATPase
HC341_RS09140	COG0625	glutathione transferase activity
HC341_RS09145	COG0564	pseudouridine synthase activity
HC341_RS09160	COG5265	(ABC) transporter
HC341_RS09165	COG2081	HI0933 family
HC341_RS09185	COG1272	protein, Hemolysin III
HC341_RS09195	COG0432	Pfam Uncharacterised protein family UPF0047
HC341_RS09215	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC341_RS09220	COG1846	Transcriptional regulator
HC341_RS09245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC341_RS09250	COG2329	Antibiotic biosynthesis monooxygenase
HC341_RS09255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC341_RS09260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC341_RS09265	COG4988	ABC transporter
HC341_RS09270	COG1294	oxidase, subunit
HC341_RS09275	COG1271	oxidase subunit
HC341_RS09285	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC341_RS09290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC341_RS09295	COG1294	oxidase, subunit
HC341_RS09300	COG1271	oxidase subunit
HC341_RS09310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC341_RS09335	COG0513	Belongs to the DEAD box helicase family
HC341_RS09365	COG2900	Belongs to the SlyX family
HC341_RS09370	COG0488	(ABC) transporter
HC341_RS09375	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC341_RS09375	COG1902	pentaerythritol trinitrate reductase activity
HC341_RS09385	COG0514	ATP-dependent DNA helicase (RecQ)
HC341_RS09400	COG1127	ABC transporter
HC341_RS09405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HC341_RS09410	COG0613	PHP domain protein
HC341_RS09470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC341_RS09475	COG1620	l-lactate permease
HC341_RS09485	COG1139	Iron-sulfur cluster binding protein
HC341_RS09490	COG0247	lactate metabolic process
HC341_RS09495	COG2154	pterin-4-alpha-carbinolamine dehydratase
HC341_RS09535	COG2915	High frequency lysogenization protein hflD homolog
HC341_RS09540	COG0482	sulfurtransferase activity
HC341_RS09550	COG0583	DNA-binding transcription factor activity
HC341_RS09555	COG2224	Isocitrate lyase
HC341_RS09560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HC341_RS09565	COG0542	response to heat
HC341_RS09570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HC341_RS09575	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HC341_RS09580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HC341_RS09590	COG1674	ftsk spoiiie
HC341_RS09595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HC341_RS09600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC341_RS09605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC341_RS09615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC341_RS09615	COG1648	precorrin-2 dehydrogenase activity
HC341_RS09625	COG1960	acyl-CoA dehydrogenase activity
HC341_RS09630	COG5001	Diguanylate cyclase
HC341_RS09630	COG3300	MHYT domain
HC341_RS09650	COG1643	Atp-dependent helicase
HC341_RS09660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC341_RS09680	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HC341_RS09695	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HC341_RS09720	COG3086	response to oxidative stress
HC341_RS09725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC341_RS09730	COG0481	GTPase activity
HC341_RS09735	COG0681	Belongs to the peptidase S26 family
HC341_RS09745	COG0571	ribonuclease III activity
HC341_RS09750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC341_RS09755	COG1381	Involved in DNA repair and RecF pathway recombination
HC341_RS09760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HC341_RS09770	COG5002	protein histidine kinase activity
HC341_RS09770	COG0784	Response regulator, receiver
HC341_RS09770	COG2205	protein histidine kinase activity
HC341_RS09785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC341_RS09790	COG0494	nUDIX hydrolase
HC341_RS09825	COG1573	uracil-dna glycosylase
HC341_RS09830	COG0322	excinuclease ABC activity
HC341_RS09835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC341_RS09860	COG0469	pyruvate kinase activity
HC341_RS09890	COG0733	neurotransmitter:sodium symporter activity
HC341_RS09900	COG0515	serine threonine protein kinase
HC341_RS09910	COG0022	dehydrogenase e1 component
HC341_RS09920	COG1104	cysteine desulfurase activity
HC341_RS09925	COG0084	hydrolase, TatD family'
HC341_RS09935	COG0470	DNA polymerase III
HC341_RS09940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC341_RS09945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC341_RS09955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC341_RS09960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC341_RS09970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC341_RS09975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC341_RS09980	COG0416	fatty acid biosynthetic process
HC341_RS09985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HC341_RS09990	COG1399	metal-binding, possibly nucleic acid-binding protein
HC341_RS09995	COG0424	maF-like protein
HC341_RS10005	COG0564	pseudouridine synthase activity
HC341_RS10010	COG1530	ribonuclease E activity
HC341_RS10015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC341_RS10020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HC341_RS10025	COG1663	tetraacyldisaccharide 4'-kinase activity
HC341_RS10030	COG0848	biopolymer transport protein
HC341_RS10035	COG0811	peptide transport
HC341_RS10040	COG2333	competence protein COMEC
HC341_RS10040	COG0658	competence protein
HC341_RS10050	COG1136	(ABC) transporter
HC341_RS10055	COG4591	ABC-type transport system involved in lipoprotein release permease component
HC341_RS10060	COG1489	DNA binding
HC341_RS10065	COG2957	Belongs to the agmatine deiminase family
HC341_RS10070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC341_RS10075	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HC341_RS10080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC341_RS10095	COG3956	TIGRFAM MazG family protein
HC341_RS10100	COG1309	transcriptional regulator
HC341_RS10110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC341_RS10115	COG0351	phosphomethylpyrimidine kinase
HC341_RS10115	COG0352	thiamine-phosphate diphosphorylase activity
HC341_RS10120	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS10125	COG0084	hydrolase, TatD family'
HC341_RS10150	COG1388	LysM domain
HC341_RS10150	COG1376	ErfK ybiS ycfS ynhG family protein
HC341_RS10155	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC341_RS10190	COG0167	dihydroorotate dehydrogenase activity
HC341_RS10230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC341_RS10240	COG3409	Peptidoglycan-binding domain 1 protein
HC341_RS10240	COG3267	Type II secretory pathway component ExeA
HC341_RS10275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC341_RS10285	COG2267	carboxylic ester hydrolase activity
HC341_RS10295	COG0308	aminopeptidase N
HC341_RS10305	COG5001	Diguanylate cyclase
HC341_RS10305	COG5002	protein histidine kinase activity
HC341_RS10310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC341_RS10320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC341_RS10330	COG0436	Aminotransferase
HC341_RS10345	COG4942	peptidase
HC341_RS10345	COG1388	LysM domain
HC341_RS10350	COG1238	metal cluster binding
HC341_RS10355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HC341_RS10360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HC341_RS10365	COG2840	Smr protein MutS2
HC341_RS10370	COG0585	pseudouridine synthase activity
HC341_RS10375	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HC341_RS10380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC341_RS10385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HC341_RS10390	COG0148	phosphopyruvate hydratase activity
HC341_RS10395	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HC341_RS10400	COG0504	CTP synthase activity
HC341_RS10405	COG0037	tRNA processing
HC341_RS10410	COG0825	malonyl-CoA metabolic process
HC341_RS10415	COG0587	DNA-directed DNA polymerase activity
HC341_RS10420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HC341_RS10435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC341_RS10440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HC341_RS10445	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HC341_RS10450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC341_RS10455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HC341_RS10475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC341_RS10485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC341_RS10490	COG0233	cytoplasmic translational termination
HC341_RS10495	COG0528	UMP kinase activity
HC341_RS10500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC341_RS10505	COG0052	Belongs to the universal ribosomal protein uS2 family
HC341_RS10510	COG0024	Methionine aminopeptidase
HC341_RS10525	COG2171	N-acyltransferase activity
HC341_RS10530	COG1393	Belongs to the ArsC family
HC341_RS10535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC341_RS10545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC341_RS10550	COG2391	methyltransferase activity
HC341_RS10565	COG0604	alcohol dehydrogenase
HC341_RS10570	COG1444	tRNA N-acetyltransferase activity
HC341_RS10585	COG1720	tRNA m6t6A37 methyltransferase activity
HC341_RS10590	COG0210	DNA helicase
HC341_RS10600	COG1111	helicase
HC341_RS10600	COG1205	dead DEAH box helicase
HC341_RS10605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC341_RS10610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HC341_RS10620	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC341_RS10630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC341_RS10635	COG0826	peptidase U32
HC341_RS10640	COG0826	peptidase U32
HC341_RS10645	COG3154	lipid carrier protein
HC341_RS10695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC341_RS10705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC341_RS10715	COG0589	response to stress
HC341_RS10725	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC341_RS10725	COG1024	Enoyl-CoA hydratase
HC341_RS10730	COG1458	PINc domain ribonuclease
HC341_RS10740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC341_RS10750	COG3268	Saccharopine dehydrogenase
HC341_RS10805	COG3300	MHYT domain
HC341_RS10805	COG5001	Diguanylate cyclase
HC341_RS10830	COG2414	aldehyde ferredoxin oxidoreductase
HC341_RS10835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HC341_RS10850	COG1192	Involved in chromosome partitioning
HC341_RS10860	COG2198	Histidine kinase
HC341_RS10860	COG0643	Histidine kinase
HC341_RS10865	COG0745	RESPONSE REGULATOR receiver
HC341_RS10870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HC341_RS10880	COG2201	protein-glutamate methylesterase activity
HC341_RS10890	COG3290	protein histidine kinase activity
HC341_RS10890	COG0840	transmembrane signaling receptor activity
HC341_RS10900	COG5001	Diguanylate cyclase
HC341_RS10900	COG5002	protein histidine kinase activity
HC341_RS10905	COG0745	RESPONSE REGULATOR receiver
HC341_RS10920	COG0745	RESPONSE REGULATOR receiver
HC341_RS10925	COG2205	protein histidine kinase activity
HC341_RS10925	COG0784	Response regulator, receiver
HC341_RS10925	COG2198	Histidine kinase
HC341_RS10935	COG3266	domain, Protein
HC341_RS10940	COG3706	GGDEF domain
HC341_RS10960	COG0835	chemotaxis
HC341_RS10970	COG1192	Involved in chromosome partitioning
HC341_RS10975	COG2201	protein-glutamate methylesterase activity
HC341_RS10980	COG2198	Histidine kinase
HC341_RS10980	COG0784	Response regulator, receiver
HC341_RS10980	COG0643	Histidine kinase
HC341_RS10985	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HC341_RS11010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC341_RS11080	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC341_RS11150	COG0248	Ppx GppA phosphatase
HC341_RS11155	COG2062	phosphohistidine phosphatase, SixA
HC341_RS11175	COG0729	surface antigen
HC341_RS11180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC341_RS11185	COG1472	Belongs to the glycosyl hydrolase 3 family
HC341_RS11195	COG2954	triphosphatase activity
HC341_RS11205	COG0588	phosphoglycerate mutase activity
HC341_RS11235	COG4176	ABC-type proline glycine betaine transport system permease component
HC341_RS11240	COG4175	Glycine betaine
HC341_RS11250	COG3105	Protein conserved in bacteria
HC341_RS11280	COG0315	cyclic pyranopterin monophosphate synthase activity
HC341_RS11290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC341_RS11340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC341_RS11340	COG2169	Transcriptional regulator
HC341_RS11345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC341_RS11350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC341_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS11355	COG0604	alcohol dehydrogenase
HC341_RS11355	COG3321	synthase
HC341_RS11375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HC341_RS11390	COG1960	acyl-CoA dehydrogenase activity
HC341_RS11400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC341_RS11410	COG3795	YCII-related domain
HC341_RS11415	COG3795	YCII-related domain
HC341_RS11420	COG4941	Belongs to the sigma-70 factor family
HC341_RS11430	COG1024	Enoyl-CoA hydratase
HC341_RS11450	COG2161	toxin-antitoxin pair type II binding
HC341_RS11455	COG2161	toxin-antitoxin pair type II binding
HC341_RS11460	COG4115	mRNA cleavage
HC341_RS11475	COG0303	'Molybdopterin
HC341_RS11490	COG2181	nitrate reductase activity
HC341_RS11495	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC341_RS11505	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC341_RS11545	COG3850	Histidine kinase
HC341_RS11550	COG2197	response regulator
HC341_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS11600	COG0789	Transcriptional regulator
HC341_RS11605	COG1960	acyl-CoA dehydrogenase activity
HC341_RS11610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC341_RS11615	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC341_RS11630	COG1760	l-serine dehydratase
HC341_RS11645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC341_RS11655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC341_RS11670	COG0631	protein serine/threonine phosphatase activity
HC341_RS11730	COG3246	L-lysine catabolic process to acetate
HC341_RS11760	COG1960	acyl-CoA dehydrogenase activity
HC341_RS11790	COG5654	RES domain protein
HC341_RS11815	COG2433	Pfam Transposase IS66
HC341_RS11820	COG3436	PFAM IS66 Orf2 family protein
HC341_RS11830	COG4942	peptidase
HC341_RS11870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC341_RS11895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC341_RS11915	COG0438	transferase activity, transferring glycosyl groups
HC341_RS11930	COG0438	transferase activity, transferring glycosyl groups
HC341_RS11950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC341_RS11970	COG1484	DNA-dependent DNA replication
HC341_RS11975	COG4584	PFAM Integrase catalytic
HC341_RS12065	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HC341_RS12085	COG3436	PFAM IS66 Orf2 family protein
HC341_RS12090	COG2433	Pfam Transposase IS66
HC341_RS12185	COG3436	PFAM IS66 Orf2 family protein
HC341_RS12190	COG2433	Pfam Transposase IS66
HC341_RS12260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC341_RS12280	COG0438	transferase activity, transferring glycosyl groups
HC341_RS12295	COG1215	transferase activity, transferring glycosyl groups
HC341_RS12455	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HC341_RS12480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC341_RS12485	COG0517	IMP dehydrogenase activity
HC341_RS12485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HC341_RS12490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HC341_RS12495	COG0572	uridine kinase
HC341_RS12515	COG1850	ribulose-bisphosphate carboxylase activity
HC341_RS12520	COG0662	Cupin 2, conserved barrel domain protein
HC341_RS12525	COG1943	Transposase
HC341_RS12540	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HC341_RS12545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HC341_RS12560	COG0385	Bile acid
HC341_RS12565	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS12585	COG3938	Belongs to the proline racemase family
HC341_RS12665	COG3046	protein related to deoxyribodipyrimidine photolyase
HC341_RS12680	COG1160	GTP binding
HC341_RS12685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC341_RS12690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC341_RS12710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC341_RS12715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC341_RS12720	COG0740	serine-type endopeptidase activity
HC341_RS12725	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC341_RS12735	COG1538	Outer membrane efflux protein
HC341_RS12755	COG2814	Major facilitator Superfamily
HC341_RS12760	COG1199	ATP-dependent helicase activity
HC341_RS12790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC341_RS12805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC341_RS12815	COG0359	binds to the 23S rRNA
HC341_RS12825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC341_RS12835	COG0360	Binds together with S18 to 16S ribosomal RNA
HC341_RS12840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC341_RS12845	COG0557	exoribonuclease II activity
HC341_RS12855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HC341_RS12860	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HC341_RS12870	COG0330	HflC and HflK could
HC341_RS12875	COG0330	HflC and HflK could
HC341_RS12880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC341_RS12885	COG1923	regulation of RNA biosynthetic process
HC341_RS12890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC341_RS12895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HC341_RS12900	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC341_RS12905	COG0802	atpase or kinase
HC341_RS12910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HC341_RS12910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC341_RS12925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC341_RS12930	COG1428	Deoxynucleoside kinase
HC341_RS12940	COG0617	tRNA 3'-terminal CCA addition
HC341_RS12955	COG0795	lipopolysaccharide-transporting ATPase activity
HC341_RS12960	COG0795	lipopolysaccharide-transporting ATPase activity
HC341_RS12965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC341_RS12980	COG0525	valine-tRNA ligase activity
HC341_RS12990	COG0456	acetyltransferase
HC341_RS12995	COG1573	uracil-dna glycosylase
HC341_RS13000	COG1183	phosphatidylcholine synthase activity
HC341_RS13005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HC341_RS13020	COG0442	prolyl-tRNA aminoacylation
HC341_RS13030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC341_RS13040	COG0489	protein tyrosine kinase activity
HC341_RS13055	COG2032	superoxide dismutase activity
HC341_RS13060	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC341_RS13065	COG0314	molybdopterin synthase activity
HC341_RS13075	COG2166	iron-sulfur cluster assembly
HC341_RS13085	COG2130	NADP-dependent
HC341_RS13090	COG1960	acyl-CoA dehydrogenase activity
HC341_RS13100	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS13120	COG1214	PFAM Peptidase M22, glycoprotease
HC341_RS13135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC341_RS13140	COG1917	Cupin 2, conserved barrel domain protein
HC341_RS13145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC341_RS13170	COG0583	DNA-binding transcription factor activity
HC341_RS13185	COG2311	Membrane
HC341_RS13195	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS13210	COG1199	ATP-dependent helicase activity
HC341_RS13220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC341_RS13225	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HC341_RS13245	COG0719	Fe-S assembly protein
HC341_RS13250	COG0396	ATPase activity
HC341_RS13255	COG0719	Fe-S assembly protein
HC341_RS13270	COG2715	membrane protein required for spore maturation
HC341_RS13305	COG4566	intracellular signal transduction
HC341_RS13310	COG4191	Histidine kinase
HC341_RS13315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC341_RS13320	COG0398	Pfam SNARE associated Golgi protein
HC341_RS13345	COG0469	pyruvate kinase activity
HC341_RS13350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC341_RS13355	COG0800	Aldolase
HC341_RS13360	COG1737	Transcriptional regulator
HC341_RS13360	COG0837	glucose binding
HC341_RS13400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC341_RS13415	COG0693	protein deglycase activity
HC341_RS13425	COG0431	NADPH-dependent FMN reductase
HC341_RS13435	COG1741	Belongs to the pirin family
HC341_RS13440	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HC341_RS13460	COG0776	regulation of translation
HC341_RS13470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC341_RS13480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC341_RS13490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC341_RS13495	COG4251	negative regulation of phosphorylation
HC341_RS13495	COG2203	Gaf domain
HC341_RS13495	COG3706	GGDEF domain
HC341_RS13495	COG5001	Diguanylate cyclase
HC341_RS13500	COG3706	GGDEF domain
HC341_RS13525	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC341_RS13570	COG0668	transmembrane transport
HC341_RS13585	COG1704	LemA family
HC341_RS13590	COG0501	Belongs to the peptidase M48B family
HC341_RS13600	COG0542	response to heat
HC341_RS13630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HC341_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS13645	COG1960	acyl-CoA dehydrogenase activity
HC341_RS13650	COG0277	FAD linked oxidase domain protein
HC341_RS13670	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC341_RS13675	COG3115	cell septum assembly
HC341_RS13690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HC341_RS13700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC341_RS13720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC341_RS13735	COG2258	MOSC domain
HC341_RS13740	COG5001	Diguanylate cyclase
HC341_RS13755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC341_RS13760	COG1256	bacterial-type flagellum assembly
HC341_RS13765	COG3951	Flagellar rod assembly protein muramidase FlgJ
HC341_RS13765	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC341_RS13770	COG1706	bacterial-type flagellum-dependent cell motility
HC341_RS13775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HC341_RS13800	COG1558	bacterial-type flagellum-dependent cell motility
HC341_RS13805	COG1815	bacterial-type flagellum-dependent cell motility
HC341_RS13815	COG0835	chemotaxis
HC341_RS13815	COG0784	Response regulator, receiver
HC341_RS13840	COG2814	Major facilitator Superfamily
HC341_RS13850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC341_RS13865	COG2133	pyrroloquinoline quinone binding
HC341_RS13875	COG4772	TonB-dependent receptor
HC341_RS13895	COG0587	DNA-directed DNA polymerase activity
HC341_RS13900	COG0215	cysteine-tRNA ligase activity
HC341_RS13905	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HC341_RS13910	COG2197	response regulator
HC341_RS13935	COG0028	Belongs to the TPP enzyme family
HC341_RS13940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HC341_RS13955	COG0735	belongs to the Fur family
HC341_RS13960	COG1538	Outer membrane efflux protein
HC341_RS13985	COG1121	(ABC) transporter
HC341_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS14020	COG0183	Belongs to the thiolase family
HC341_RS14025	COG1960	acyl-CoA dehydrogenase activity
HC341_RS14030	COG1960	acyl-CoA dehydrogenase activity
HC341_RS14035	COG1960	acyl-CoA dehydrogenase activity
HC341_RS14040	COG0235	Class ii aldolase
HC341_RS14045	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC341_RS14050	COG0822	iron-sulfur transferase activity
HC341_RS14065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HC341_RS14065	COG3608	succinylglutamate desuccinylase aspartoacylase
HC341_RS14095	COG3279	Response regulator of the LytR AlgR family
HC341_RS14095	COG5000	phosphorelay sensor kinase activity
HC341_RS14105	COG2133	pyrroloquinoline quinone binding
HC341_RS14115	COG2205	protein histidine kinase activity
HC341_RS14120	COG0596	Alpha beta hydrolase
HC341_RS14125	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HC341_RS14135	COG3402	PFAM membrane-flanked domain
HC341_RS14140	COG1714	RDD family
HC341_RS14165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC341_RS14170	COG4137	Cytochrome C assembly protein
HC341_RS14175	COG4536	flavin adenine dinucleotide binding
HC341_RS14180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HC341_RS14185	COG4535	Mg2 and Co2 transporter CorC
HC341_RS14190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC341_RS14195	COG1702	phosphate starvation-inducible protein PhoH
HC341_RS14200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC341_RS14205	COG0268	Binds directly to 16S ribosomal RNA
HC341_RS14210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC341_RS14215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC341_RS14220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC341_RS14225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC341_RS14230	COG0142	geranyltranstransferase activity
HC341_RS14265	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HC341_RS14275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HC341_RS14280	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS14285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC341_RS14300	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC341_RS14310	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HC341_RS14315	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HC341_RS14320	COG0352	thiamine-phosphate diphosphorylase activity
HC341_RS14325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HC341_RS14330	COG0653	protein targeting
HC341_RS14340	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HC341_RS14345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC341_RS14355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC341_RS14360	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC341_RS14365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC341_RS14370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC341_RS14375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC341_RS14380	COG0772	Belongs to the SEDS family
HC341_RS14385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC341_RS14390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC341_RS14395	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC341_RS14400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC341_RS14415	COG0275	rRNA processing
HC341_RS14420	COG2001	Belongs to the MraZ family
HC341_RS14425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC341_RS14430	COG3107	peptidoglycan biosynthetic process
HC341_RS14435	COG0792	nuclease activity
HC341_RS14440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HC341_RS14450	COG2969	positive regulation of protein catabolic process
HC341_RS14455	COG0625	glutathione transferase activity
HC341_RS14460	COG2857	Cytochrome c1
HC341_RS14465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC341_RS14470	COG0723	plastoquinol--plastocyanin reductase activity
HC341_RS14475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC341_RS14485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC341_RS14490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC341_RS14495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HC341_RS14500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC341_RS14515	COG2854	intermembrane phospholipid transfer
HC341_RS14520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HC341_RS14525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HC341_RS14530	COG1127	ABC transporter
HC341_RS14535	COG0530	calcium, potassium:sodium antiporter activity
HC341_RS14545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HC341_RS14560	COG1137	ATPase activity
HC341_RS14580	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HC341_RS14585	COG1660	Displays ATPase and GTPase activities
HC341_RS14595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC341_RS14605	COG0312	modulator of DNA gyrase
HC341_RS14610	COG0312	modulator of DNA gyrase
HC341_RS14625	COG1530	ribonuclease E activity
HC341_RS14630	COG0424	maF-like protein
HC341_RS14635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HC341_RS14645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC341_RS14650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC341_RS14655	COG1466	dna polymerase III delta subunit
HC341_RS14665	COG0495	leucyl-tRNA aminoacylation
HC341_RS14685	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HC341_RS14725	COG1607	acyl-coa hydrolase
HC341_RS14730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC341_RS14740	COG0346	lactoylglutathione lyase activity
HC341_RS14745	COG2130	NADP-dependent
HC341_RS14780	COG3360	Dodecin
HC341_RS14785	COG3189	MarR family transcriptional regulator
HC341_RS14800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC341_RS14800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC341_RS14815	COG2133	pyrroloquinoline quinone binding
HC341_RS14820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC341_RS14825	COG0542	response to heat
HC341_RS14835	COG1960	acyl-CoA dehydrogenase activity
HC341_RS14845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HC341_RS14850	COG0183	Belongs to the thiolase family
HC341_RS14865	COG1024	Enoyl-CoA hydratase
HC341_RS14870	COG1024	Enoyl-CoA hydratase
HC341_RS14875	COG1960	acyl-CoA dehydrogenase activity
HC341_RS14915	COG1022	Amp-dependent synthetase and ligase
HC341_RS14920	COG0629	single-stranded DNA binding
HC341_RS14925	COG2814	Major facilitator Superfamily
HC341_RS14930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC341_RS14935	COG0039	L-malate dehydrogenase activity
HC341_RS14950	COG0203	ribosomal protein L17
HC341_RS14955	COG0202	RNA polymerase activity
HC341_RS14960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC341_RS14965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC341_RS14970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC341_RS14975	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC341_RS14980	COG0201	protein transport
HC341_RS14985	COG0200	Binds to the 23S rRNA
HC341_RS14990	COG1841	ribosomal large subunit assembly
HC341_RS14995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HC341_RS15000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC341_RS15005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC341_RS15010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC341_RS15015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC341_RS15020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC341_RS15025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HC341_RS15030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC341_RS15035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC341_RS15040	COG0255	Belongs to the universal ribosomal protein uL29 family
HC341_RS15045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC341_RS15050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HC341_RS15055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HC341_RS15065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC341_RS15070	COG0089	rRNA binding
HC341_RS15075	COG0088	Forms part of the polypeptide exit tunnel
HC341_RS15080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC341_RS15085	COG0051	transcription antitermination factor activity, RNA binding
HC341_RS15090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC341_RS15095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC341_RS15100	COG0049	tRNA binding
HC341_RS15105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC341_RS15110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC341_RS15115	COG0085	RNA polymerase activity
HC341_RS15120	COG0222	ribosome binding
HC341_RS15125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC341_RS15130	COG0081	regulation of translation
HC341_RS15135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HC341_RS15155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC341_RS15175	COG0517	IMP dehydrogenase activity
HC341_RS15175	COG0617	tRNA 3'-terminal CCA addition
HC341_RS15175	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC341_RS15180	COG0840	transmembrane signaling receptor activity
HC341_RS15190	COG0012	GTP binding
HC341_RS15195	COG0193	aminoacyl-tRNA hydrolase activity
HC341_RS15200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC341_RS15205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC341_RS15215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC341_RS15220	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HC341_RS15230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HC341_RS15235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC341_RS15240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC341_RS15245	COG1121	(ABC) transporter
HC341_RS15255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC341_RS15260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HC341_RS15265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC341_RS15270	COG2835	tetraacyldisaccharide 4'-kinase activity
HC341_RS15275	COG2890	protein-(glutamine-N5) methyltransferase activity
HC341_RS15280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC341_RS15285	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HC341_RS15290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC341_RS15295	COG0154	amidase activity
HC341_RS15300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC341_RS15305	COG1077	Cell shape determining protein MreB Mrl
HC341_RS15310	COG1792	Involved in formation and maintenance of cell shape
HC341_RS15315	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC341_RS15320	COG0768	penicillin binding
HC341_RS15325	COG0772	Belongs to the SEDS family
HC341_RS15330	COG2951	lytic endotransglycosylase activity
HC341_RS15340	COG1686	Belongs to the peptidase S11 family
HC341_RS15345	COG2921	Belongs to the UPF0250 family
HC341_RS15350	COG0321	lipoyl(octanoyl) transferase activity
HC341_RS15360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC341_RS15370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HC341_RS15375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC341_RS15380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HC341_RS15385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC341_RS15390	COG0589	response to stress
HC341_RS15395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC341_RS15400	COG2967	ApaG domain
HC341_RS15405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC341_RS15410	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HC341_RS15420	COG1331	Highly conserved protein containing a thioredoxin domain
HC341_RS15430	COG0151	Belongs to the GarS family
HC341_RS15460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HC341_RS15465	COG0205	6-phosphofructokinase activity
HC341_RS15475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC341_RS15490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC341_RS15495	COG0352	thiamine-phosphate diphosphorylase activity
HC341_RS15500	COG1773	rubredoxin
HC341_RS15510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC341_RS15520	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HC341_RS15520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC341_RS15530	COG4991	sh3 domain protein
HC341_RS15545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HC341_RS15560	COG0415	Belongs to the DNA photolyase family
HC341_RS15570	COG2200	EAL domain
HC341_RS15575	COG0302	gtp cyclohydrolase
HC341_RS15580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC341_RS15595	COG3263	regulation of cellular component size
HC341_RS15635	COG0564	pseudouridine synthase activity
HC341_RS15655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC341_RS15660	COG0045	succinate-CoA ligase (ADP-forming) activity
HC341_RS15705	COG3706	GGDEF domain
HC341_RS15710	COG2433	Pfam Transposase IS66
HC341_RS15735	COG0316	Belongs to the HesB IscA family
HC341_RS15740	COG4566	intracellular signal transduction
HC341_RS15745	COG4191	Histidine kinase
HC341_RS15750	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS15760	COG0589	response to stress
HC341_RS15765	COG1960	acyl-CoA dehydrogenase activity
HC341_RS15780	COG0330	HflC and HflK could
HC341_RS15815	COG3549	Plasmid maintenance system killer
HC341_RS15830	COG2986	histidine ammonia-lyase
HC341_RS15840	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS15855	COG3267	Type II secretory pathway component ExeA
HC341_RS15855	COG3409	Peptidoglycan-binding domain 1 protein
HC341_RS15900	COG1216	Glycosyl transferase, family 2
HC341_RS15910	COG2327	Polysaccharide pyruvyl transferase
HC341_RS15920	COG1132	(ABC) transporter
HC341_RS15945	COG2433	Pfam Transposase IS66
HC341_RS15950	COG0463	Glycosyl transferase, family 2
HC341_RS15950	COG1216	Glycosyl transferase, family 2
HC341_RS15955	COG1216	Glycosyl transferase, family 2
HC341_RS15975	COG2433	Pfam Transposase IS66
HC341_RS15990	COG0367	asparagine synthase
HC341_RS15995	COG0438	transferase activity, transferring glycosyl groups
HC341_RS16045	COG1215	transferase activity, transferring glycosyl groups
HC341_RS16065	COG4372	Transposase
HC341_RS16090	COG2198	Histidine kinase
HC341_RS16090	COG0643	Histidine kinase
HC341_RS16095	COG2204	response regulator
HC341_RS16115	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HC341_RS16120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC341_RS16125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC341_RS16130	COG3706	GGDEF domain
HC341_RS16155	COG0300	oxidoreductase activity
HC341_RS16180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC341_RS16185	COG2226	methyltransferase
HC341_RS16195	COG1595	DNA-templated transcription, initiation
HC341_RS16200	COG2226	methyltransferase
HC341_RS16220	COG3713	MltA-interacting MipA family protein
HC341_RS16235	COG1131	(ABC) transporter
HC341_RS16245	COG0175	sulfate reduction
HC341_RS16265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC341_RS16285	COG4969	Belongs to the N-Me-Phe pilin family
HC341_RS16320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC341_RS16335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC341_RS16340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC341_RS16345	COG0196	riboflavin kinase activity
HC341_RS16350	COG0728	peptidoglycan biosynthetic process
HC341_RS16400	COG0166	Belongs to the GPI family
HC341_RS16415	COG1218	3'(2'),5'-bisphosphate nucleotidase
HC341_RS16420	COG0529	Catalyzes the synthesis of activated sulfate
HC341_RS16420	COG2046	Belongs to the sulfate adenylyltransferase family
HC341_RS16425	COG3273	potassium ion transport
HC341_RS16425	COG0471	metal ion transport
HC341_RS16440	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HC341_RS16455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HC341_RS16460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC341_RS16470	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HC341_RS16475	COG1765	OsmC-like protein
HC341_RS16485	COG0134	indole-3-glycerol-phosphate synthase activity
HC341_RS16490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC341_RS16505	COG0546	phosphoglycolate phosphatase activity
HC341_RS16510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC341_RS16520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HC341_RS16530	COG1309	transcriptional regulator
HC341_RS16545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC341_RS16555	COG0616	signal peptide processing
HC341_RS16575	COG0425	Belongs to the sulfur carrier protein TusA family
HC341_RS16590	COG1028	Short-chain dehydrogenase reductase Sdr
HC341_RS16600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC341_RS16600	COG1042	CoA-binding domain protein
HC341_RS16600	COG0045	succinate-CoA ligase (ADP-forming) activity
HC341_RS16605	COG0840	transmembrane signaling receptor activity
HC341_RS16615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC341_RS16625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HC341_RS16635	COG0484	heat shock protein binding
HC341_RS16645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HC341_RS16650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC341_RS16660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC341_RS16680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC341_RS16700	COG4067	protein conserved in archaea
HC341_RS16700	COG0189	ligase activity
HC341_RS16715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HC341_RS16720	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC341_RS16725	COG2983	Belongs to the UPF0260 family
HC341_RS16730	COG2204	response regulator
HC341_RS16735	COG4191	Histidine kinase
HC341_RS16745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC341_RS16755	COG2885	chlorophyll binding
HC341_RS16760	COG0109	protoheme IX farnesyltransferase activity
HC341_RS16765	COG1612	heme a metabolic process
HC341_RS16795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC341_RS16800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC341_RS16815	COG2226	methyltransferase
HC341_RS16820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HC341_RS16825	COG1040	competence protein
HC341_RS16835	COG1595	DNA-templated transcription, initiation
HC341_RS16855	COG0668	transmembrane transport
HC341_RS16865	COG0281	malic enzyme
HC341_RS16865	COG0280	phosphate acetyltransferase
HC341_RS16885	COG0438	transferase activity, transferring glycosyl groups
HC341_RS16900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC341_RS16900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC341_RS16905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC341_RS16925	COG0501	Belongs to the peptidase M48B family
HC341_RS16930	COG3706	GGDEF domain
HC341_RS16935	COG2267	carboxylic ester hydrolase activity
HC341_RS16970	COG3501	Rhs element vgr protein
HC341_RS17020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC341_RS17060	COG2165	general secretion pathway protein
HC341_RS17090	COG0494	nUDIX hydrolase
HC341_RS17105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HC341_RS17115	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC341_RS17130	COG2030	dehydratase
HC341_RS17135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HC341_RS17140	COG4181	ATPase activity
HC341_RS17150	COG2974	May be involved in recombination
HC341_RS17155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC341_RS17160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC341_RS17185	COG3243	poly(R)-hydroxyalkanoic acid synthase
HC341_RS17195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC341_RS17210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC341_RS17215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC341_RS17220	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HC341_RS17250	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HC341_RS17255	COG1194	a g-specific adenine glycosylase
HC341_RS17280	COG2022	thiamine diphosphate biosynthetic process
HC341_RS17285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC341_RS17290	COG0667	Aldo Keto reductase
HC341_RS17300	COG1515	deoxyribonuclease V activity
HC341_RS17305	COG2204	response regulator
HC341_RS17330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC341_RS17340	COG0492	ferredoxin-NADP+ reductase activity
HC341_RS17350	COG0708	Exodeoxyribonuclease III
HC341_RS17355	COG0183	Belongs to the thiolase family
HC341_RS17365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HC341_RS17370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC341_RS17375	COG1073	alpha beta
HC341_RS17380	COG2267	carboxylic ester hydrolase activity
HC341_RS17385	COG0205	6-phosphofructokinase activity
HC341_RS17395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HC341_RS17405	COG0756	dUTP diphosphatase activity
HC341_RS17410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC341_RS17415	COG2003	Belongs to the UPF0758 family
HC341_RS17430	COG2177	Part of the ABC transporter FtsEX involved in
HC341_RS17435	COG2884	Cell division ATP-binding protein ftsE
HC341_RS17440	COG0552	protein localization to endoplasmic reticulum
HC341_RS17445	COG0612	Peptidase, M16
HC341_RS17450	COG0612	Peptidase, M16
HC341_RS17455	COG0742	ribosomal rna small subunit methyltransferase
HC341_RS17460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC341_RS17465	COG0405	Gamma-glutamyltransferase
HC341_RS17485	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HC341_RS17510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC341_RS17535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC341_RS17540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HC341_RS17545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC341_RS17550	COG0071	Belongs to the small heat shock protein (HSP20) family
HC341_RS17565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC341_RS17570	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HC341_RS17575	COG0848	biopolymer transport protein
HC341_RS17580	COG0848	biopolymer transport protein
HC341_RS17585	COG0811	peptide transport
HC341_RS17605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HC341_RS17610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC341_RS17615	COG1519	Transferase
HC341_RS17620	COG0859	PFAM glycosyl transferase family 9
HC341_RS17625	COG3642	lipopolysaccharide core region biosynthetic process
HC341_RS17630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HC341_RS17630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HC341_RS17635	COG1560	Kdo2-lipid A biosynthetic process
HC341_RS17690	COG0438	transferase activity, transferring glycosyl groups
HC341_RS17700	COG0457	Tetratricopeptide repeat
HC341_RS17705	COG0438	transferase activity, transferring glycosyl groups
HC341_RS17720	COG1132	(ABC) transporter
HC341_RS17735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HC341_RS17740	COG0459	protein refolding
HC341_RS17745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HC341_RS17750	COG1324	tolerance protein
HC341_RS17755	COG4232	protein-disulfide reductase activity
HC341_RS17760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC341_RS17765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HC341_RS17770	COG0511	ligase activity, forming carbon-carbon bonds
HC341_RS17775	COG0439	Biotin carboxylase
HC341_RS17785	COG0730	response to heat
HC341_RS17795	COG0617	tRNA 3'-terminal CCA addition
HC341_RS17810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC341_RS17825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HC341_RS17830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC341_RS17835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HC341_RS17840	COG1610	YqeY-like protein
HC341_RS17845	COG0358	DNA primase activity
HC341_RS17915	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HC341_RS17925	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC341_RS17935	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HC341_RS17960	COG4608	Belongs to the ABC transporter superfamily
HC341_RS17965	COG0444	Belongs to the ABC transporter superfamily
HC341_RS17990	COG0735	belongs to the Fur family
HC341_RS18070	COG0004	ammonium transporteR
HC341_RS18075	COG0347	Belongs to the P(II) protein family
HC341_RS18115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HC341_RS18120	COG0830	nickel cation binding
HC341_RS18125	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HC341_RS18130	COG0804	urea catabolic process
HC341_RS18135	COG0832	Belongs to the urease beta subunit family
HC341_RS18140	COG0831	urea catabolic process
HC341_RS18145	COG0829	nickel cation binding
HC341_RS18175	COG0318	PFAM AMP-dependent synthetase and ligase
HC341_RS18210	COG1473	amidohydrolase
HC341_RS18220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HC341_RS18265	COG0583	DNA-binding transcription factor activity
HC341_RS18275	COG5001	Diguanylate cyclase
HC341_RS18275	COG5002	protein histidine kinase activity
HC341_RS18355	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC341_RS18360	COG0523	cobalamin synthesis protein
HC341_RS18370	COG0523	cobalamin synthesis protein
HC341_RS18395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC341_RS18440	COG0842	Transport permease protein
HC341_RS18445	COG1131	(ABC) transporter
HC341_RS18455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC341_RS18475	COG0596	Alpha beta hydrolase
HC341_RS18480	COG1024	Enoyl-CoA hydratase
HC341_RS18490	COG1960	acyl-CoA dehydrogenase activity
HC341_RS18500	COG2308	Evidence 4 Homologs of previously reported genes of
HC341_RS18520	COG2308	Evidence 4 Homologs of previously reported genes of
HC341_RS18530	COG2826	transposase and inactivated derivatives, IS30 family
HC341_RS18560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC341_RS18565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC341_RS18570	COG1333	cytochrome c biogenesis protein
HC341_RS18580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HC341_RS18605	COG0210	DNA helicase
HC341_RS18615	COG0745	RESPONSE REGULATOR receiver
HC341_RS18620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC341_RS18625	COG0589	response to stress
HC341_RS18630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC341_RS18635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HC341_RS18640	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC341_RS18650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC341_RS18655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC341_RS18660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC341_RS18670	COG0356	it plays a direct role in the translocation of protons across the membrane
HC341_RS18680	COG1475	DNA binding
HC341_RS18685	COG1192	Involved in chromosome partitioning
HC341_RS18690	COG0357	Ribosomal RNA small subunit methyltransferase G
HC341_RS18695	COG0445	tRNA wobble uridine modification
HC341_RS18705	COG0706	membrane insertase activity
HC341_RS18710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC341_RS18715	COG0594	ribonuclease P activity
HC341_RS18720	COG0230	Belongs to the bacterial ribosomal protein bL34 family