locus-tag	class	description
GSR16_RS00010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GSR16_RS00040	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GSR16_RS00050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GSR16_RS00055	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
GSR16_RS00075	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GSR16_RS00095	COG0495	leucyl-tRNA aminoacylation
GSR16_RS00105	COG1466	dna polymerase III delta subunit
GSR16_RS00115	COG1196	nuclear chromosome segregation
GSR16_RS00115	COG0741	lytic transglycosylase activity
GSR16_RS00115	COG0739	heme binding
GSR16_RS00125	COG0450	alkyl hydroperoxide reductase
GSR16_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GSR16_RS00150	COG0799	negative regulation of ribosome biogenesis
GSR16_RS00155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GSR16_RS00160	COG0288	reversible hydration of carbon dioxide
GSR16_RS00180	COG0640	Transcriptional regulator
GSR16_RS00185	COG2391	methyltransferase activity
GSR16_RS00200	COG4783	chaperone-mediated protein folding
GSR16_RS00210	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSR16_RS00215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSR16_RS00230	COG1473	amidohydrolase
GSR16_RS00235	COG1957	nucleoside hydrolase
GSR16_RS00255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GSR16_RS00265	COG0138	bifunctional purine biosynthesis protein purh
GSR16_RS00285	COG0009	L-threonylcarbamoyladenylate synthase
GSR16_RS00295	COG0697	spore germination
GSR16_RS00300	COG2188	Transcriptional regulator
GSR16_RS00305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GSR16_RS00310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSR16_RS00315	COG1263	PTS System
GSR16_RS00315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSR16_RS00315	COG2190	(PTS) system
GSR16_RS00320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GSR16_RS00325	COG1522	sequence-specific DNA binding
GSR16_RS00330	COG0745	RESPONSE REGULATOR receiver
GSR16_RS00345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GSR16_RS00350	COG3945	hemerythrin HHE cation binding domain
GSR16_RS00360	COG3158	transport of potassium into the cell
GSR16_RS00365	COG0442	prolyl-tRNA aminoacylation
GSR16_RS00375	COG1914	H( )-stimulated, divalent metal cation uptake system
GSR16_RS00380	COG1846	Transcriptional regulator
GSR16_RS00405	COG0028	Belongs to the TPP enzyme family
GSR16_RS00410	COG0440	acetolactate synthase activity
GSR16_RS00415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GSR16_RS00420	COG1183	phosphatidylcholine synthase activity
GSR16_RS00425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSR16_RS00430	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GSR16_RS00445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GSR16_RS00450	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GSR16_RS00480	COG1612	heme a metabolic process
GSR16_RS00485	COG0109	protoheme IX farnesyltransferase activity
GSR16_RS00490	COG1999	signal sequence binding
GSR16_RS00495	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GSR16_RS00500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GSR16_RS00505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GSR16_RS00510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSR16_RS00515	COG0131	Imidazoleglycerol-phosphate dehydratase
GSR16_RS00520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GSR16_RS00525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GSR16_RS00530	COG0107	imidazoleglycerol-phosphate synthase activity
GSR16_RS00535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GSR16_RS00540	COG0140	phosphoribosyl-ATP diphosphatase activity
GSR16_RS00550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSR16_RS00555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSR16_RS00600	COG1538	Outer membrane efflux protein
GSR16_RS00605	COG0840	transmembrane signaling receptor activity
GSR16_RS00610	COG0084	hydrolase, TatD family'
GSR16_RS00680	COG0582	viral genome integration into host DNA
GSR16_RS00700	COG0792	nuclease activity
GSR16_RS00705	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GSR16_RS00710	COG2823	Periplasmic or secreted lipoprotein
GSR16_RS00715	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GSR16_RS00725	COG1720	tRNA m6t6A37 methyltransferase activity
GSR16_RS00735	COG0445	tRNA wobble uridine modification
GSR16_RS00740	COG0357	Ribosomal RNA small subunit methyltransferase G
GSR16_RS00745	COG1192	Involved in chromosome partitioning
GSR16_RS00760	COG0356	it plays a direct role in the translocation of protons across the membrane
GSR16_RS00770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GSR16_RS00775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSR16_RS00780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GSR16_RS00785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GSR16_RS00790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GSR16_RS00795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GSR16_RS00800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GSR16_RS00805	COG1349	DNA-binding transcription factor activity
GSR16_RS00810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GSR16_RS00820	COG1396	sequence-specific DNA binding
GSR16_RS00830	COG3238	Protein conserved in bacteria
GSR16_RS00835	COG0477	Major facilitator Superfamily
GSR16_RS00860	COG0583	DNA-binding transcription factor activity
GSR16_RS00865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GSR16_RS00870	COG3706	GGDEF domain
GSR16_RS00875	COG0408	coproporphyrinogen oxidase activity
GSR16_RS00885	COG2205	protein histidine kinase activity
GSR16_RS00890	COG0745	RESPONSE REGULATOR receiver
GSR16_RS00895	COG1966	Carbon starvation protein
GSR16_RS00900	COG2879	small protein
GSR16_RS00905	COG2855	membrane
GSR16_RS00910	COG0583	DNA-binding transcription factor activity
GSR16_RS00915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GSR16_RS00925	COG1611	Belongs to the LOG family
GSR16_RS00960	COG2814	Major facilitator Superfamily
GSR16_RS00965	COG1566	PFAM secretion protein HlyD family protein
GSR16_RS00970	COG1538	Outer membrane efflux protein
GSR16_RS00975	COG1846	Transcriptional regulator
GSR16_RS00980	COG1393	Belongs to the ArsC family
GSR16_RS00985	COG2814	Major facilitator Superfamily
GSR16_RS01015	COG0583	DNA-binding transcription factor activity
GSR16_RS01020	COG1960	acyl-CoA dehydrogenase activity
GSR16_RS01025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GSR16_RS01030	COG0477	Major facilitator Superfamily
GSR16_RS01035	COG1024	Enoyl-CoA hydratase
GSR16_RS01040	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSR16_RS01055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GSR16_RS01060	COG1242	4 iron, 4 sulfur cluster binding
GSR16_RS01070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GSR16_RS01075	COG2813	Specifically methylates the guanine in position
GSR16_RS01075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GSR16_RS01080	COG2814	Major facilitator Superfamily
GSR16_RS01090	COG2223	nitrite transmembrane transporter activity
GSR16_RS01095	COG2207	Transcriptional regulator
GSR16_RS01110	COG1959	2 iron, 2 sulfur cluster binding
GSR16_RS01110	COG1295	ribonuclease BN
GSR16_RS01125	COG1648	precorrin-2 dehydrogenase activity
GSR16_RS01125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSR16_RS01135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSR16_RS01140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSR16_RS01145	COG0859	PFAM glycosyl transferase family 9
GSR16_RS01150	COG0438	transferase activity, transferring glycosyl groups
GSR16_RS01165	COG0297	glycogen (starch) synthase activity
GSR16_RS01170	COG1132	(ABC) transporter
GSR16_RS01180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GSR16_RS01185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSR16_RS01220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSR16_RS01225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSR16_RS01235	COG1538	Outer membrane efflux protein
GSR16_RS01240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSR16_RS01245	COG1283	sodium-dependent phosphate transmembrane transporter activity
GSR16_RS01270	COG0142	geranyltranstransferase activity
GSR16_RS01275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GSR16_RS01280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GSR16_RS01285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GSR16_RS01295	COG4215	(ABC) transporter
GSR16_RS01300	COG4160	amino acid transport
GSR16_RS01335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSR16_RS01355	COG1196	nuclear chromosome segregation
GSR16_RS01365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSR16_RS01380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSR16_RS01390	COG0840	transmembrane signaling receptor activity
GSR16_RS01425	COG3501	Rhs element vgr protein
GSR16_RS01440	COG1349	DNA-binding transcription factor activity
GSR16_RS01445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GSR16_RS01470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GSR16_RS01475	COG0339	signal peptide processing
GSR16_RS01485	COG2194	sulfuric ester hydrolase activity
GSR16_RS01490	COG0708	Exodeoxyribonuclease III
GSR16_RS01495	COG2226	methyltransferase
GSR16_RS01510	COG0473	3-isopropylmalate dehydrogenase activity
GSR16_RS01515	COG0438	transferase activity, transferring glycosyl groups
GSR16_RS01535	COG0745	RESPONSE REGULATOR receiver
GSR16_RS01540	COG0642	Histidine kinase
GSR16_RS01560	COG0318	PFAM AMP-dependent synthetase and ligase
GSR16_RS01590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSR16_RS01600	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS01605	COG2197	response regulator
GSR16_RS01610	COG0583	DNA-binding transcription factor activity
GSR16_RS01630	COG3094	Invasion gene expression up-regulator, SirB
GSR16_RS01635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GSR16_RS01640	COG1074	ATP-dependent DNA helicase activity
GSR16_RS01655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GSR16_RS01675	COG2205	protein histidine kinase activity
GSR16_RS01675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS01680	COG2193	ferroxidase activity
GSR16_RS01695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GSR16_RS01700	COG0114	fumarate hydratase activity
GSR16_RS01745	COG1917	Cupin 2, conserved barrel domain protein
GSR16_RS01745	COG2169	Transcriptional regulator
GSR16_RS01760	COG3245	cytochrome
GSR16_RS01770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GSR16_RS01780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GSR16_RS01790	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GSR16_RS01795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GSR16_RS01805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GSR16_RS01810	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GSR16_RS01815	COG0193	aminoacyl-tRNA hydrolase activity
GSR16_RS01820	COG0012	GTP binding
GSR16_RS01845	COG1022	Amp-dependent synthetase and ligase
GSR16_RS01850	COG0626	cystathionine gamma-synthase activity
GSR16_RS01860	COG1982	Orn Lys Arg decarboxylase major
GSR16_RS01870	COG0069	glutamate synthase activity
GSR16_RS01870	COG0070	glutamate synthase
GSR16_RS01870	COG0067	glutamate synthase
GSR16_RS01880	COG0493	'glutamate synthase
GSR16_RS01890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GSR16_RS01900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GSR16_RS01935	COG3958	Transketolase
GSR16_RS01940	COG3959	Transketolase, thiamine diphosphate binding domain
GSR16_RS01955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GSR16_RS01965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GSR16_RS01980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GSR16_RS01985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSR16_RS01995	COG0459	protein refolding
GSR16_RS02000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GSR16_RS02005	COG0723	plastoquinol--plastocyanin reductase activity
GSR16_RS02010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GSR16_RS02015	COG2857	Cytochrome c1
GSR16_RS02020	COG0625	glutathione transferase activity
GSR16_RS02025	COG2969	positive regulation of protein catabolic process
GSR16_RS02035	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GSR16_RS02040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GSR16_RS02045	COG2203	Gaf domain
GSR16_RS02045	COG4251	negative regulation of phosphorylation
GSR16_RS02045	COG5001	Diguanylate cyclase
GSR16_RS02045	COG3706	GGDEF domain
GSR16_RS02050	COG1879	ABC-type sugar transport system periplasmic component
GSR16_RS02055	COG1522	sequence-specific DNA binding
GSR16_RS02065	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GSR16_RS02075	COG0625	glutathione transferase activity
GSR16_RS02090	COG0561	phosphatase activity
GSR16_RS02110	COG0583	DNA-binding transcription factor activity
GSR16_RS02115	COG1301	dicarboxylic acid transport
GSR16_RS02125	COG2095	MarC family integral membrane protein
GSR16_RS02145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GSR16_RS02155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GSR16_RS02160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GSR16_RS02165	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GSR16_RS02170	COG0813	purine-nucleoside phosphorylase activity
GSR16_RS02180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GSR16_RS02185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GSR16_RS02195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GSR16_RS02200	COG0316	Belongs to the HesB IscA family
GSR16_RS02205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GSR16_RS02210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS02215	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GSR16_RS02235	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GSR16_RS02240	COG0123	including yeast histone deacetylase and acetoin utilization protein
GSR16_RS02245	COG0714	Associated with various cellular activities
GSR16_RS02260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSR16_RS02270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GSR16_RS02275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GSR16_RS02280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GSR16_RS02290	COG0045	succinate-CoA ligase (ADP-forming) activity
GSR16_RS02290	COG1042	CoA-binding domain protein
GSR16_RS02290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSR16_RS02295	COG0228	four-way junction DNA binding
GSR16_RS02300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GSR16_RS02305	COG0336	Belongs to the RNA methyltransferase TrmD family
GSR16_RS02310	COG0335	large ribosomal subunit rRNA binding
GSR16_RS02315	COG4974	Belongs to the 'phage' integrase family
GSR16_RS02320	COG0542	response to heat
GSR16_RS02325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GSR16_RS02330	COG1278	Cold shock
GSR16_RS02360	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GSR16_RS02375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GSR16_RS02380	COG0584	glycerophosphoryl diester phosphodiesterase
GSR16_RS02385	COG4095	Psort location CytoplasmicMembrane, score
GSR16_RS02405	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GSR16_RS02420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSR16_RS02425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSR16_RS02430	COG1959	2 iron, 2 sulfur cluster binding
GSR16_RS02435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSR16_RS02435	COG1017	nitric oxide dioxygenase activity
GSR16_RS02440	COG0840	transmembrane signaling receptor activity
GSR16_RS02455	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS02480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GSR16_RS02480	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSR16_RS02490	COG0477	Major facilitator Superfamily
GSR16_RS02500	COG2113	Glycine betaine
GSR16_RS02520	COG1902	pentaerythritol trinitrate reductase activity
GSR16_RS02520	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSR16_RS02525	COG2181	nitrate reductase activity
GSR16_RS02525	COG0247	lactate metabolic process
GSR16_RS02530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GSR16_RS02545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSR16_RS02550	COG4175	Glycine betaine
GSR16_RS02595	COG3383	formate dehydrogenase (NAD+) activity
GSR16_RS02615	COG3539	Fimbrial protein
GSR16_RS02635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSR16_RS02645	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GSR16_RS02650	COG2610	gluconate transmembrane transporter activity
GSR16_RS02660	COG0572	uridine kinase
GSR16_RS02665	COG0625	glutathione transferase activity
GSR16_RS02675	COG0633	Ferredoxin
GSR16_RS02680	COG0443	Heat shock 70 kDa protein
GSR16_RS02685	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GSR16_RS02695	COG0822	iron-sulfur transferase activity
GSR16_RS02700	COG1104	cysteine desulfurase activity
GSR16_RS02715	COG0747	negative chemotaxis
GSR16_RS02720	COG0601	transmembrane transport
GSR16_RS02725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSR16_RS02730	COG0444	Belongs to the ABC transporter superfamily
GSR16_RS02735	COG4608	Belongs to the ABC transporter superfamily
GSR16_RS02740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GSR16_RS02755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSR16_RS02785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSR16_RS02790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS02795	COG0174	glutamine synthetase
GSR16_RS02800	COG0494	nUDIX hydrolase
GSR16_RS02805	COG0187	DNA topoisomerase II activity
GSR16_RS02810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSR16_RS02815	COG0564	pseudouridine synthase activity
GSR16_RS02820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GSR16_RS02820	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GSR16_RS02830	COG0728	peptidoglycan biosynthetic process
GSR16_RS02835	COG0268	Binds directly to 16S ribosomal RNA
GSR16_RS02840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GSR16_RS02850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GSR16_RS02865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GSR16_RS02875	COG0450	alkyl hydroperoxide reductase
GSR16_RS02885	COG3706	GGDEF domain
GSR16_RS02895	COG4181	ATPase activity
GSR16_RS02900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GSR16_RS02910	COG2807	transmembrane transport
GSR16_RS02915	COG2186	Transcriptional regulator
GSR16_RS02925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GSR16_RS02930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GSR16_RS02935	COG0470	DNA polymerase III
GSR16_RS02945	COG0084	hydrolase, TatD family'
GSR16_RS02950	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GSR16_RS02950	COG0321	lipoyl(octanoyl) transferase activity
GSR16_RS02960	COG3045	CreA protein
GSR16_RS02975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GSR16_RS02985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSR16_RS03005	COG0288	reversible hydration of carbon dioxide
GSR16_RS03010	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS03010	COG1454	alcohol dehydrogenase
GSR16_RS03040	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS03045	COG1024	Enoyl-CoA hydratase
GSR16_RS03050	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSR16_RS03060	COG3396	Phenylacetate-CoA oxygenase
GSR16_RS03065	COG3460	Phenylacetate-CoA oxygenase
GSR16_RS03070	COG3396	Phenylacetate-CoA oxygenase
GSR16_RS03075	COG2151	metal-sulfur cluster biosynthetic enzyme
GSR16_RS03080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSR16_RS03090	COG1024	Enoyl-CoA hydratase
GSR16_RS03095	COG0183	Belongs to the thiolase family
GSR16_RS03105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GSR16_RS03115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSR16_RS03120	COG2132	Multicopper oxidase
GSR16_RS03125	COG1937	Protein conserved in bacteria
GSR16_RS03135	COG0360	Binds together with S18 to 16S ribosomal RNA
GSR16_RS03145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GSR16_RS03150	COG0359	binds to the 23S rRNA
GSR16_RS03155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS03195	COG1335	isochorismatase
GSR16_RS03200	COG0277	FAD linked oxidase domain protein
GSR16_RS03200	COG0247	lactate metabolic process
GSR16_RS03205	COG0456	acetyltransferase
GSR16_RS03210	COG0456	acetyltransferase
GSR16_RS03225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GSR16_RS03230	COG3300	MHYT domain
GSR16_RS03230	COG5001	Diguanylate cyclase
GSR16_RS03235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GSR16_RS03245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GSR16_RS03245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSR16_RS03255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GSR16_RS03260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GSR16_RS03265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GSR16_RS03270	COG0560	Phosphoserine phosphatase
GSR16_RS03285	COG0494	nUDIX hydrolase
GSR16_RS03310	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GSR16_RS03315	COG3161	chorismate lyase activity
GSR16_RS03325	COG1346	cytolysis
GSR16_RS03335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GSR16_RS03340	COG0583	DNA-binding transcription factor activity
GSR16_RS03350	COG3852	Histidine kinase
GSR16_RS03375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSR16_RS03380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSR16_RS03385	COG2239	Acts as a magnesium transporter
GSR16_RS03395	COG1047	Peptidyl-prolyl cis-trans
GSR16_RS03400	COG2850	peptidyl-arginine hydroxylation
GSR16_RS03410	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GSR16_RS03415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSR16_RS03420	COG0488	(ABC) transporter
GSR16_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS03430	COG0583	DNA-binding transcription factor activity
GSR16_RS03435	COG0175	sulfate reduction
GSR16_RS03455	COG0196	riboflavin kinase activity
GSR16_RS03460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GSR16_RS03465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GSR16_RS03470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GSR16_RS03480	COG3960	tartronate-semialdehyde synthase activity
GSR16_RS03485	COG3622	Belongs to the hyi family
GSR16_RS03490	COG2084	Dehydrogenase
GSR16_RS03515	COG3648	Uricase
GSR16_RS03515	COG3195	allantoin biosynthetic process
GSR16_RS03525	COG4266	Belongs to the allantoicase family
GSR16_RS03535	COG2233	PERMEase
GSR16_RS03545	COG0326	Molecular chaperone. Has ATPase activity
GSR16_RS03565	COG0583	DNA-binding transcription factor activity
GSR16_RS03570	COG1742	UPF0060 membrane protein
GSR16_RS03575	COG0625	glutathione transferase activity
GSR16_RS03600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GSR16_RS03605	COG0583	DNA-binding transcription factor activity
GSR16_RS03610	COG0531	amino acid
GSR16_RS03620	COG2224	Isocitrate lyase
GSR16_RS03625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GSR16_RS03630	COG0443	Heat shock 70 kDa protein
GSR16_RS03635	COG0484	heat shock protein binding
GSR16_RS03660	COG0583	DNA-binding transcription factor activity
GSR16_RS03665	COG0473	3-isopropylmalate dehydrogenase activity
GSR16_RS03690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSR16_RS03700	COG1063	alcohol dehydrogenase
GSR16_RS03705	COG0752	glycyl-tRNA synthetase alpha subunit
GSR16_RS03720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GSR16_RS03745	COG0400	carboxylic ester hydrolase activity
GSR16_RS03750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GSR16_RS03755	COG1280	lysine exporter protein (LysE YggA)
GSR16_RS03760	COG0745	RESPONSE REGULATOR receiver
GSR16_RS03760	COG3706	GGDEF domain
GSR16_RS03770	COG0560	Phosphoserine phosphatase
GSR16_RS03785	COG3220	belongs to the UPF0276 family
GSR16_RS03800	COG0602	queuosine metabolic process
GSR16_RS03805	COG0720	synthase
GSR16_RS03810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GSR16_RS03815	COG1597	lipid kinase activity
GSR16_RS03825	COG1902	pentaerythritol trinitrate reductase activity
GSR16_RS03830	COG0778	Nitroreductase
GSR16_RS03835	COG1309	transcriptional regulator
GSR16_RS03865	COG4969	Belongs to the N-Me-Phe pilin family
GSR16_RS03870	COG1454	alcohol dehydrogenase
GSR16_RS03900	COG4968	Prepilin-type N-terminal cleavage methylation domain
GSR16_RS03905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GSR16_RS03915	COG2885	chlorophyll binding
GSR16_RS03945	COG1122	ATPase activity
GSR16_RS03950	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GSR16_RS03955	COG0310	cobalt ion transport
GSR16_RS03970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSR16_RS04010	COG0726	polysaccharide deacetylase
GSR16_RS04030	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS04035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSR16_RS04040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSR16_RS04045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSR16_RS04060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GSR16_RS04075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GSR16_RS04090	COG5001	Diguanylate cyclase
GSR16_RS04090	COG3300	MHYT domain
GSR16_RS04100	COG0004	ammonium transporteR
GSR16_RS04105	COG1252	NADH dehydrogenase
GSR16_RS04110	COG0583	DNA-binding transcription factor activity
GSR16_RS04135	COG1335	isochorismatase
GSR16_RS04150	COG2203	Gaf domain
GSR16_RS04150	COG5001	Diguanylate cyclase
GSR16_RS04150	COG4251	negative regulation of phosphorylation
GSR16_RS04150	COG3706	GGDEF domain
GSR16_RS04170	COG1671	Belongs to the UPF0178 family
GSR16_RS04190	COG0590	tRNA wobble adenosine to inosine editing
GSR16_RS04215	COG0463	Glycosyl transferase, family 2
GSR16_RS04230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GSR16_RS04230	COG0519	Catalyzes the synthesis of GMP from XMP
GSR16_RS04240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GSR16_RS04250	COG2914	Belongs to the UPF0125 (RnfH) family
GSR16_RS04255	COG3706	GGDEF domain
GSR16_RS04260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GSR16_RS04265	COG0148	phosphopyruvate hydratase activity
GSR16_RS04270	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GSR16_RS04275	COG0504	CTP synthase activity
GSR16_RS04280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GSR16_RS04285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GSR16_RS04295	COG1573	uracil-dna glycosylase
GSR16_RS04300	COG0456	acetyltransferase
GSR16_RS04305	COG1214	PFAM Peptidase M22, glycoprotease
GSR16_RS04310	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GSR16_RS04315	COG2198	Histidine kinase
GSR16_RS04315	COG0643	Histidine kinase
GSR16_RS04320	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GSR16_RS04325	COG0745	RESPONSE REGULATOR receiver
GSR16_RS04330	COG0835	chemotaxis
GSR16_RS04330	COG0784	Response regulator, receiver
GSR16_RS04335	COG0835	chemotaxis
GSR16_RS04335	COG0784	Response regulator, receiver
GSR16_RS04340	COG2205	protein histidine kinase activity
GSR16_RS04350	COG0840	transmembrane signaling receptor activity
GSR16_RS04355	COG0745	RESPONSE REGULATOR receiver
GSR16_RS04360	COG2198	Histidine kinase
GSR16_RS04360	COG0643	Histidine kinase
GSR16_RS04370	COG0840	transmembrane signaling receptor activity
GSR16_RS04375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GSR16_RS04380	COG2201	protein-glutamate methylesterase activity
GSR16_RS04385	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GSR16_RS04395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSR16_RS04400	COG0531	amino acid
GSR16_RS04405	COG2235	arginine
GSR16_RS04410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSR16_RS04420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GSR16_RS04425	COG0509	glycine decarboxylation via glycine cleavage system
GSR16_RS04430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSR16_RS04430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSR16_RS04435	COG3300	MHYT domain
GSR16_RS04435	COG5001	Diguanylate cyclase
GSR16_RS04440	COG0747	negative chemotaxis
GSR16_RS04465	COG1704	LemA family
GSR16_RS04475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GSR16_RS04485	COG0424	maF-like protein
GSR16_RS04490	COG1399	metal-binding, possibly nucleic acid-binding protein
GSR16_RS04495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GSR16_RS04500	COG0416	fatty acid biosynthetic process
GSR16_RS04505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GSR16_RS04510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GSR16_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS04520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSR16_RS04525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSR16_RS04530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GSR16_RS04535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSR16_RS04540	COG2200	EAL domain
GSR16_RS04540	COG2199	diguanylate cyclase activity
GSR16_RS04550	COG0287	Prephenate dehydrogenase
GSR16_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS04610	COG3501	Rhs element vgr protein
GSR16_RS04670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS04680	COG0023	Translation Initiation Factor
GSR16_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS04700	COG2211	Major facilitator Superfamily
GSR16_RS04705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSR16_RS04705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSR16_RS04710	COG1105	Belongs to the carbohydrate kinase PfkB family
GSR16_RS04715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSR16_RS04715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSR16_RS04720	COG1609	Transcriptional regulator
GSR16_RS04725	COG0583	DNA-binding transcription factor activity
GSR16_RS04735	COG3038	cytochrome b561
GSR16_RS04745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GSR16_RS04750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GSR16_RS04760	COG0776	regulation of translation
GSR16_RS04770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GSR16_RS04775	COG0284	orotidine-5'-phosphate decarboxylase activity
GSR16_RS04785	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GSR16_RS04785	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GSR16_RS04790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSR16_RS04810	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS04815	COG4689	acetoacetate decarboxylase
GSR16_RS04820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GSR16_RS04830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GSR16_RS04845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSR16_RS04860	COG0395	ABC-type sugar transport system, permease component
GSR16_RS04875	COG3842	ATPase activity
GSR16_RS04880	COG4948	Mandelate Racemase Muconate Lactonizing
GSR16_RS04885	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS04900	COG5001	Diguanylate cyclase
GSR16_RS04900	COG1716	ATPase activity
GSR16_RS04910	COG0583	DNA-binding transcription factor activity
GSR16_RS04940	COG0517	IMP dehydrogenase activity
GSR16_RS04975	COG1648	precorrin-2 dehydrogenase activity
GSR16_RS04975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSR16_RS04980	COG2010	Cytochrome c
GSR16_RS04985	COG3256	nitric oxide reductase
GSR16_RS04990	COG1845	cytochrome c oxidase, subunit III
GSR16_RS05000	COG0714	Associated with various cellular activities
GSR16_RS05080	COG2194	sulfuric ester hydrolase activity
GSR16_RS05090	COG4774	siderophore transport
GSR16_RS05095	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GSR16_RS05120	COG1120	ATPase activity
GSR16_RS05130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GSR16_RS05135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GSR16_RS05140	COG3706	GGDEF domain
GSR16_RS05145	COG2197	response regulator
GSR16_RS05150	COG3850	Histidine kinase
GSR16_RS05160	COG2223	nitrite transmembrane transporter activity
GSR16_RS05175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GSR16_RS05180	COG1140	nitrate reductase beta subunit
GSR16_RS05185	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GSR16_RS05190	COG2181	nitrate reductase activity
GSR16_RS05195	COG0583	DNA-binding transcription factor activity
GSR16_RS05200	COG2723	6-phospho-beta-galactosidase activity
GSR16_RS05205	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GSR16_RS05210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSR16_RS05225	COG2354	Protein conserved in bacteria
GSR16_RS05235	COG3186	Phenylalanine-4-hydroxylase
GSR16_RS05240	COG3706	GGDEF domain
GSR16_RS05240	COG0745	RESPONSE REGULATOR receiver
GSR16_RS05260	COG3437	response regulator, receiver
GSR16_RS05260	COG4999	Histidine kinase
GSR16_RS05260	COG2205	protein histidine kinase activity
GSR16_RS05260	COG3850	Histidine kinase
GSR16_RS05300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSR16_RS05305	COG4208	sulfate ABC transporter
GSR16_RS05310	COG3842	ATPase activity
GSR16_RS05315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GSR16_RS05325	COG1522	sequence-specific DNA binding
GSR16_RS05330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS05335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GSR16_RS05345	COG4566	intracellular signal transduction
GSR16_RS05360	COG1741	Belongs to the pirin family
GSR16_RS05375	COG1802	Transcriptional regulator
GSR16_RS05400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GSR16_RS05405	COG0788	formyltetrahydrofolate deformylase activity
GSR16_RS05425	COG1968	undecaprenyl-diphosphatase activity
GSR16_RS05450	COG2308	Evidence 4 Homologs of previously reported genes of
GSR16_RS05490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSR16_RS05495	COG2137	regulation of response to DNA damage stimulus
GSR16_RS05500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GSR16_RS05505	COG1420	regulation of RNA biosynthetic process
GSR16_RS05510	COG2951	lytic endotransglycosylase activity
GSR16_RS05515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GSR16_RS05520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GSR16_RS05530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GSR16_RS05535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSR16_RS05545	COG2095	MarC family integral membrane protein
GSR16_RS05550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSR16_RS05555	COG1393	Belongs to the ArsC family
GSR16_RS05565	COG0318	PFAM AMP-dependent synthetase and ligase
GSR16_RS05570	COG0779	Required for maturation of 30S ribosomal subunits
GSR16_RS05575	COG2251	uridine kinase activity
GSR16_RS05575	COG0195	Participates in both transcription termination and antitermination
GSR16_RS05580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GSR16_RS05585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GSR16_RS05590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GSR16_RS05595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GSR16_RS05600	COG1185	polyribonucleotide nucleotidyltransferase activity
GSR16_RS05605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GSR16_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS05625	COG3724	N-succinylarginine dihydrolase activity
GSR16_RS05630	COG0559	Belongs to the binding-protein-dependent transport system permease family
GSR16_RS05640	COG0411	ABC transporter
GSR16_RS05655	COG1058	Belongs to the CinA family
GSR16_RS05655	COG1546	Belongs to the CinA family
GSR16_RS05680	COG1024	Enoyl-CoA hydratase
GSR16_RS05685	COG1024	Enoyl-CoA hydratase
GSR16_RS05690	COG1960	acyl-CoA dehydrogenase activity
GSR16_RS05700	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSR16_RS05705	COG0789	Transcriptional regulator
GSR16_RS05710	COG0183	Belongs to the thiolase family
GSR16_RS05715	COG0628	permease
GSR16_RS05730	COG3174	membrane
GSR16_RS05735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GSR16_RS05740	COG0142	geranyltranstransferase activity
GSR16_RS05745	COG1722	exodeoxyribonuclease VII activity
GSR16_RS05750	COG0300	oxidoreductase activity
GSR16_RS05790	COG4221	oxidoreductase activity
GSR16_RS05805	COG0525	valine-tRNA ligase activity
GSR16_RS05810	COG0745	RESPONSE REGULATOR receiver
GSR16_RS05810	COG3706	GGDEF domain
GSR16_RS05825	COG0583	DNA-binding transcription factor activity
GSR16_RS05830	COG0625	glutathione transferase activity
GSR16_RS05835	COG2261	transglycosylase associated protein
GSR16_RS05840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSR16_RS05850	COG3706	GGDEF domain
GSR16_RS05855	COG0756	dUTP diphosphatase activity
GSR16_RS05860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GSR16_RS05865	COG2003	Belongs to the UPF0758 family
GSR16_RS05890	COG0121	glutamine amidotransferase
GSR16_RS05895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSR16_RS05905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSR16_RS05910	COG0697	spore germination
GSR16_RS05915	COG2070	2-Nitropropane dioxygenase
GSR16_RS05920	COG1335	isochorismatase
GSR16_RS05935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GSR16_RS05940	COG0833	amino acid
GSR16_RS05960	COG1454	alcohol dehydrogenase
GSR16_RS05965	COG0583	DNA-binding transcription factor activity
GSR16_RS05990	COG2995	paraquat-inducible protein a
GSR16_RS05995	COG2995	paraquat-inducible protein a
GSR16_RS06000	COG3008	intermembrane lipid transfer
GSR16_RS06000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GSR16_RS06015	COG0697	spore germination
GSR16_RS06020	COG1187	pseudouridine synthase activity
GSR16_RS06025	COG2267	carboxylic ester hydrolase activity
GSR16_RS06050	COG0183	Belongs to the thiolase family
GSR16_RS06055	COG3243	poly(R)-hydroxyalkanoic acid synthase
GSR16_RS06060	COG0179	Fumarylacetoacetate (FAA) hydrolase
GSR16_RS06065	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GSR16_RS06070	COG2814	Major facilitator Superfamily
GSR16_RS06080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GSR16_RS06090	COG0066	3-isopropylmalate dehydratase activity
GSR16_RS06095	COG2226	methyltransferase
GSR16_RS06100	COG0473	3-isopropylmalate dehydrogenase activity
GSR16_RS06125	COG0101	tRNA pseudouridine synthase activity
GSR16_RS06135	COG0133	tryptophan synthase activity
GSR16_RS06140	COG0159	tryptophan synthase activity
GSR16_RS06145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GSR16_RS06150	COG0277	FAD linked oxidase domain protein
GSR16_RS06155	COG0488	(ABC) transporter
GSR16_RS06160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GSR16_RS06165	COG1765	OsmC-like protein
GSR16_RS06170	COG1815	bacterial-type flagellum-dependent cell motility
GSR16_RS06175	COG1558	bacterial-type flagellum-dependent cell motility
GSR16_RS06180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GSR16_RS06185	COG1749	Flagellar hook protein flgE
GSR16_RS06195	COG4786	Flagellar basal body rod
GSR16_RS06200	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GSR16_RS06205	COG1706	bacterial-type flagellum-dependent cell motility
GSR16_RS06210	COG3951	Flagellar rod assembly protein muramidase FlgJ
GSR16_RS06210	COG1705	Flagellar rod assembly protein muramidase FlgJ
GSR16_RS06215	COG1256	bacterial-type flagellum assembly
GSR16_RS06225	COG2988	succinylglutamate desuccinylase activity
GSR16_RS06230	COG1024	Enoyl-CoA hydratase
GSR16_RS06230	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSR16_RS06240	COG2200	EAL domain
GSR16_RS06250	COG3842	ATPase activity
GSR16_RS06255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS06260	COG1166	arginine decarboxylase activity
GSR16_RS06265	COG0531	amino acid
GSR16_RS06280	COG0482	sulfurtransferase activity
GSR16_RS06310	COG1914	H( )-stimulated, divalent metal cation uptake system
GSR16_RS06320	COG0251	oxidation-reduction process
GSR16_RS06325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GSR16_RS06330	COG2925	Exonuclease
GSR16_RS06335	COG1435	thymidine kinase activity
GSR16_RS06345	COG0586	Pfam SNARE associated Golgi protein
GSR16_RS06350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSR16_RS06355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSR16_RS06360	COG1862	Preprotein translocase
GSR16_RS06365	COG0343	queuine tRNA-ribosyltransferase activity
GSR16_RS06375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GSR16_RS06380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GSR16_RS06385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GSR16_RS06390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GSR16_RS06395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GSR16_RS06400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSR16_RS06400	COG0072	phenylalanine-tRNA ligase activity
GSR16_RS06405	COG0776	regulation of translation
GSR16_RS06470	COG1196	nuclear chromosome segregation
GSR16_RS06515	COG3023	N-Acetylmuramoyl-L-alanine amidase
GSR16_RS06530	COG3447	MASE1 domain protein
GSR16_RS06530	COG5001	Diguanylate cyclase
GSR16_RS06530	COG5002	protein histidine kinase activity
GSR16_RS06550	COG0798	PFAM Bile acid sodium symporter
GSR16_RS06555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSR16_RS06575	COG0583	DNA-binding transcription factor activity
GSR16_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS06605	COG0840	transmembrane signaling receptor activity
GSR16_RS06625	COG2198	Histidine kinase
GSR16_RS06625	COG2205	protein histidine kinase activity
GSR16_RS06625	COG0784	Response regulator, receiver
GSR16_RS06630	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS06660	COG1970	mechanosensitive ion channel activity
GSR16_RS06680	COG0354	folic acid binding
GSR16_RS06695	COG2866	Carboxypeptidase
GSR16_RS06710	COG3226	Transcriptional regulator
GSR16_RS06725	COG1538	Outer membrane efflux protein
GSR16_RS06730	COG1120	ATPase activity
GSR16_RS06735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSR16_RS06750	COG2819	hydrolase of the alpha beta superfamily
GSR16_RS06755	COG4774	siderophore transport
GSR16_RS06755	COG1629	transport
GSR16_RS06760	COG1538	Outer membrane efflux protein
GSR16_RS06770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSR16_RS06775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSR16_RS06795	COG1764	response to oxidative stress
GSR16_RS06805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSR16_RS06815	COG0457	Tetratricopeptide repeat
GSR16_RS06820	COG0726	polysaccharide deacetylase
GSR16_RS06820	COG1649	PFAM Uncharacterised BCR, COG1649
GSR16_RS06825	COG1215	transferase activity, transferring glycosyl groups
GSR16_RS06835	COG0840	transmembrane signaling receptor activity
GSR16_RS06840	COG2318	DinB family
GSR16_RS06855	COG2204	response regulator
GSR16_RS06875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GSR16_RS06905	COG1773	rubredoxin
GSR16_RS06910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSR16_RS06955	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GSR16_RS06985	COG2453	phosphatase
GSR16_RS06985	COG0671	phosphoesterase, PA-phosphatase related
GSR16_RS06990	COG2267	carboxylic ester hydrolase activity
GSR16_RS07000	COG4589	Belongs to the CDS family
GSR16_RS07005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GSR16_RS07010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSR16_RS07015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSR16_RS07025	COG2350	Protein conserved in bacteria
GSR16_RS07030	COG2917	probably involved in intracellular septation
GSR16_RS07035	COG0330	HflC and HflK could
GSR16_RS07045	COG1739	Uncharacterized protein family UPF0029
GSR16_RS07055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSR16_RS07065	COG0516	GMP reductase activity
GSR16_RS07070	COG0840	transmembrane signaling receptor activity
GSR16_RS07080	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GSR16_RS07095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GSR16_RS07110	COG2096	Adenosyltransferase
GSR16_RS07120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GSR16_RS07125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GSR16_RS07135	COG0492	ferredoxin-NADP+ reductase activity
GSR16_RS07145	COG1309	transcriptional regulator
GSR16_RS07150	COG0859	PFAM glycosyl transferase family 9
GSR16_RS07165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GSR16_RS07175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSR16_RS07180	COG0312	modulator of DNA gyrase
GSR16_RS07185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS07190	COG0583	DNA-binding transcription factor activity
GSR16_RS07200	COG0745	RESPONSE REGULATOR receiver
GSR16_RS07205	COG2205	protein histidine kinase activity
GSR16_RS07225	COG3706	GGDEF domain
GSR16_RS07260	COG1185	polyribonucleotide nucleotidyltransferase activity
GSR16_RS07290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSR16_RS07325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GSR16_RS07350	COG1278	Cold shock
GSR16_RS07360	COG0643	Histidine kinase
GSR16_RS07360	COG2198	Histidine kinase
GSR16_RS07365	COG0412	Dienelactone hydrolase
GSR16_RS07380	COG3123	guanosine phosphorylase activity
GSR16_RS07385	COG2771	luxR family
GSR16_RS07385	COG2200	EAL domain
GSR16_RS07390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GSR16_RS07405	COG1289	transmembrane transporter activity
GSR16_RS07415	COG1566	PFAM secretion protein HlyD family protein
GSR16_RS07470	COG0778	Nitroreductase
GSR16_RS07475	COG1797	cobyrinic acid a,c-diamide synthase activity
GSR16_RS07505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSR16_RS07505	COG1648	precorrin-2 dehydrogenase activity
GSR16_RS07510	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
GSR16_RS07540	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GSR16_RS07550	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GSR16_RS07555	COG1492	cobalamin metabolic process
GSR16_RS07575	COG2072	flavoprotein involved in K transport
GSR16_RS07595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSR16_RS07600	COG0436	Aminotransferase
GSR16_RS07605	COG0583	DNA-binding transcription factor activity
GSR16_RS07640	COG0210	DNA helicase
GSR16_RS07705	COG2814	Major facilitator Superfamily
GSR16_RS07745	COG0583	DNA-binding transcription factor activity
GSR16_RS07750	COG2814	Major facilitator Superfamily
GSR16_RS07760	COG1760	l-serine dehydratase
GSR16_RS07770	COG0583	DNA-binding transcription factor activity
GSR16_RS07775	COG2040	homocysteine
GSR16_RS07780	COG0840	transmembrane signaling receptor activity
GSR16_RS07785	COG4521	taurine ABC transporter
GSR16_RS07790	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GSR16_RS07795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSR16_RS07800	COG2175	clavaminate synthase activity
GSR16_RS07805	COG0513	Belongs to the DEAD box helicase family
GSR16_RS07810	COG0840	transmembrane signaling receptor activity
GSR16_RS07825	COG0583	DNA-binding transcription factor activity
GSR16_RS07835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS07850	COG0688	phosphatidylethanolamine metabolic process
GSR16_RS07855	COG3706	GGDEF domain
GSR16_RS07855	COG0745	RESPONSE REGULATOR receiver
GSR16_RS07895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSR16_RS07905	COG0481	GTPase activity
GSR16_RS07920	COG0571	ribonuclease III activity
GSR16_RS07925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GSR16_RS07935	COG1381	Involved in DNA repair and RecF pathway recombination
GSR16_RS07940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GSR16_RS07945	COG0736	holo-[acyl-carrier-protein] synthase activity
GSR16_RS07950	COG1472	Belongs to the glycosyl hydrolase 3 family
GSR16_RS07960	COG3437	response regulator, receiver
GSR16_RS07960	COG2770	Histidine kinase
GSR16_RS07965	COG1643	Atp-dependent helicase
GSR16_RS07975	COG2831	hemolysin activation secretion protein
GSR16_RS08030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GSR16_RS08085	COG1619	proteins homologs of microcin C7 resistance protein MccF
GSR16_RS08095	COG0175	sulfate reduction
GSR16_RS08100	COG2895	sulfate adenylyltransferase (ATP) activity
GSR16_RS08105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GSR16_RS08110	COG0564	pseudouridine synthase activity
GSR16_RS08150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GSR16_RS08195	COG1215	transferase activity, transferring glycosyl groups
GSR16_RS08205	COG1045	serine acetyltransferase
GSR16_RS08250	COG0840	transmembrane signaling receptor activity
GSR16_RS08275	COG1294	oxidase, subunit
GSR16_RS08285	COG0583	DNA-binding transcription factor activity
GSR16_RS08290	COG4221	oxidoreductase activity
GSR16_RS08315	COG0656	L-ascorbic acid biosynthetic process
GSR16_RS08320	COG2814	Major facilitator Superfamily
GSR16_RS08325	COG0583	DNA-binding transcription factor activity
GSR16_RS08330	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
GSR16_RS08340	COG3040	lipid binding
GSR16_RS08345	COG3046	protein related to deoxyribodipyrimidine photolyase
GSR16_RS08370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GSR16_RS08380	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
GSR16_RS08380	COG0493	'glutamate synthase
GSR16_RS08385	COG1309	transcriptional regulator
GSR16_RS08400	COG3938	Belongs to the proline racemase family
GSR16_RS08445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSR16_RS08450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GSR16_RS08460	COG0667	Aldo Keto reductase
GSR16_RS08475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSR16_RS08485	COG1538	Outer membrane efflux protein
GSR16_RS08500	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS08510	COG3938	Belongs to the proline racemase family
GSR16_RS08515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSR16_RS08525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS08540	COG0473	3-isopropylmalate dehydrogenase activity
GSR16_RS08545	COG0583	DNA-binding transcription factor activity
GSR16_RS08550	COG0583	DNA-binding transcription factor activity
GSR16_RS08560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GSR16_RS08570	COG2707	UPF0756 membrane protein
GSR16_RS08580	COG0745	RESPONSE REGULATOR receiver
GSR16_RS08580	COG3706	GGDEF domain
GSR16_RS08610	COG0745	RESPONSE REGULATOR receiver
GSR16_RS08615	COG5002	protein histidine kinase activity
GSR16_RS08630	COG2205	protein histidine kinase activity
GSR16_RS08630	COG0784	Response regulator, receiver
GSR16_RS08645	COG4191	Histidine kinase
GSR16_RS08655	COG0840	transmembrane signaling receptor activity
GSR16_RS08705	COG0004	ammonium transporteR
GSR16_RS08720	COG2267	carboxylic ester hydrolase activity
GSR16_RS08730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSR16_RS08735	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS08750	COG1176	ABC-type spermidine putrescine transport system, permease component I
GSR16_RS08760	COG3842	ATPase activity
GSR16_RS08770	COG2188	Transcriptional regulator
GSR16_RS08775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GSR16_RS08785	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GSR16_RS08795	COG0679	Auxin Efflux Carrier
GSR16_RS08805	COG1802	Transcriptional regulator
GSR16_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS08815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GSR16_RS08825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GSR16_RS08845	COG3052	prosthetic group binding
GSR16_RS08890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GSR16_RS08895	COG1686	Belongs to the peptidase S11 family
GSR16_RS08900	COG2921	Belongs to the UPF0250 family
GSR16_RS08905	COG0321	lipoyl(octanoyl) transferase activity
GSR16_RS08910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GSR16_RS08930	COG1278	Cold shock
GSR16_RS08940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSR16_RS08945	COG0420	3'-5' exonuclease activity
GSR16_RS08950	COG0419	ATPase involved in DNA repair
GSR16_RS08980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GSR16_RS08985	COG2197	response regulator
GSR16_RS08995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSR16_RS09000	COG1136	(ABC) transporter
GSR16_RS09000	COG0577	efflux transmembrane transporter activity
GSR16_RS09005	COG1538	Outer membrane efflux protein
GSR16_RS09010	COG2814	Major facilitator Superfamily
GSR16_RS09015	COG1566	PFAM secretion protein HlyD family protein
GSR16_RS09020	COG1538	Outer membrane efflux protein
GSR16_RS09035	COG0174	glutamine synthetase
GSR16_RS09040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSR16_RS09045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GSR16_RS09055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GSR16_RS09065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GSR16_RS09100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GSR16_RS09110	COG0840	transmembrane signaling receptor activity
GSR16_RS09115	COG3437	response regulator, receiver
GSR16_RS09125	COG0513	Belongs to the DEAD box helicase family
GSR16_RS09130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GSR16_RS09145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GSR16_RS09150	COG4149	molybdate abc transporter
GSR16_RS09160	COG0436	Aminotransferase
GSR16_RS09180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GSR16_RS09185	COG1215	transferase activity, transferring glycosyl groups
GSR16_RS09230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GSR16_RS09260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GSR16_RS09275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GSR16_RS09290	COG1024	Enoyl-CoA hydratase
GSR16_RS09305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GSR16_RS09310	COG1674	ftsk spoiiie
GSR16_RS09315	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GSR16_RS09325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GSR16_RS09330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GSR16_RS09345	COG0667	Aldo Keto reductase
GSR16_RS09350	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GSR16_RS09360	COG1309	transcriptional regulator
GSR16_RS09365	COG1538	Outer membrane efflux protein
GSR16_RS09370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSR16_RS09375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSR16_RS09380	COG0747	negative chemotaxis
GSR16_RS09395	COG2130	NADP-dependent
GSR16_RS09400	COG2217	Heavy metal translocating P-type atpase
GSR16_RS09415	COG0346	lactoylglutathione lyase activity
GSR16_RS09445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GSR16_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS09485	COG1741	Belongs to the pirin family
GSR16_RS09500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GSR16_RS09500	COG0047	phosphoribosylformylglycinamidine synthase activity
GSR16_RS09525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GSR16_RS09525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSR16_RS09540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSR16_RS09595	COG3550	peptidyl-serine autophosphorylation
GSR16_RS09615	COG3042	response to heat
GSR16_RS09630	COG0582	viral genome integration into host DNA
GSR16_RS09710	COG1131	(ABC) transporter
GSR16_RS09730	COG3245	cytochrome
GSR16_RS09765	COG4263	nitrous-oxide reductase activity
GSR16_RS09770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSR16_RS09800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSR16_RS09810	COG0583	DNA-binding transcription factor activity
GSR16_RS09815	COG2318	DinB family
GSR16_RS09830	COG0243	molybdopterin cofactor binding
GSR16_RS09840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSR16_RS09845	COG2223	nitrite transmembrane transporter activity
GSR16_RS09855	COG3707	response regulator
GSR16_RS09860	COG2197	response regulator
GSR16_RS09865	COG3781	membrane
GSR16_RS09870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GSR16_RS09875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GSR16_RS09885	COG1294	oxidase, subunit
GSR16_RS09895	COG0243	molybdopterin cofactor binding
GSR16_RS09900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSR16_RS09910	COG3437	response regulator, receiver
GSR16_RS09940	COG0583	DNA-binding transcription factor activity
GSR16_RS09945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GSR16_RS09950	COG3002	Belongs to the UPF0753 family
GSR16_RS09955	COG0009	L-threonylcarbamoyladenylate synthase
GSR16_RS09990	COG0534	Mate efflux family protein
GSR16_RS09995	COG2824	Alkylphosphonate utilization operon protein PhnA
GSR16_RS10010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS10015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GSR16_RS10025	COG2119	membrane
GSR16_RS10035	COG0583	DNA-binding transcription factor activity
GSR16_RS10040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSR16_RS10065	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GSR16_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS10080	COG2197	response regulator
GSR16_RS10105	COG4977	sequence-specific DNA binding
GSR16_RS10130	COG0123	including yeast histone deacetylase and acetoin utilization protein
GSR16_RS10135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSR16_RS10145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GSR16_RS10150	COG0497	DNA recombination
GSR16_RS10190	COG1876	peptidase activity
GSR16_RS10215	COG3501	Rhs element vgr protein
GSR16_RS10340	COG2205	protein histidine kinase activity
GSR16_RS10340	COG0784	Response regulator, receiver
GSR16_RS10340	COG2198	Histidine kinase
GSR16_RS10345	COG2197	response regulator
GSR16_RS10350	COG3850	Histidine kinase
GSR16_RS10350	COG5002	protein histidine kinase activity
GSR16_RS10355	COG3842	ATPase activity
GSR16_RS10365	COG1176	ABC-type spermidine putrescine transport system, permease component I
GSR16_RS10370	COG1177	transmembrane transport
GSR16_RS10380	COG3706	GGDEF domain
GSR16_RS10395	COG1763	Mo-molybdopterin cofactor biosynthetic process
GSR16_RS10415	COG4598	ABC transporter
GSR16_RS10420	COG4160	amino acid transport
GSR16_RS10425	COG4215	(ABC) transporter
GSR16_RS10435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GSR16_RS10440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GSR16_RS10445	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GSR16_RS10450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSR16_RS10455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GSR16_RS10475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GSR16_RS10480	COG0575	Belongs to the CDS family
GSR16_RS10485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GSR16_RS10490	COG0233	cytoplasmic translational termination
GSR16_RS10495	COG0528	UMP kinase activity
GSR16_RS10500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GSR16_RS10505	COG0052	Belongs to the universal ribosomal protein uS2 family
GSR16_RS10520	COG0477	Major facilitator Superfamily
GSR16_RS10530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GSR16_RS10535	COG2816	NAD+ diphosphatase activity
GSR16_RS10545	COG0166	Belongs to the GPI family
GSR16_RS10550	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GSR16_RS10555	COG0501	Belongs to the peptidase M48B family
GSR16_RS10560	COG2154	pterin-4-alpha-carbinolamine dehydratase
GSR16_RS10570	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS10575	COG1956	GAF domain-containing protein
GSR16_RS10585	COG0745	RESPONSE REGULATOR receiver
GSR16_RS10590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSR16_RS10600	COG0443	Heat shock 70 kDa protein
GSR16_RS10610	COG2321	neutral zinc metallopeptidase
GSR16_RS10615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GSR16_RS10620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GSR16_RS10625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSR16_RS10630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GSR16_RS10640	COG0307	riboflavin synthase, alpha
GSR16_RS10645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GSR16_RS10660	COG1063	alcohol dehydrogenase
GSR16_RS10665	COG0842	Transport permease protein
GSR16_RS10670	COG0842	Transport permease protein
GSR16_RS10670	COG1129	ABC transporter
GSR16_RS10675	COG1131	(ABC) transporter
GSR16_RS10680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSR16_RS10710	COG3447	MASE1 domain protein
GSR16_RS10710	COG5002	protein histidine kinase activity
GSR16_RS10710	COG5001	Diguanylate cyclase
GSR16_RS10730	COG0583	DNA-binding transcription factor activity
GSR16_RS10740	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GSR16_RS10745	COG0745	RESPONSE REGULATOR receiver
GSR16_RS10765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GSR16_RS10770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSR16_RS10775	COG1045	serine acetyltransferase
GSR16_RS10785	COG1464	Belongs to the NlpA lipoprotein family
GSR16_RS10790	COG2011	ABC-type metal ion transport system permease component
GSR16_RS10795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GSR16_RS10805	COG1116	anion transmembrane transporter activity
GSR16_RS10810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSR16_RS10815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSR16_RS10820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GSR16_RS10825	COG0431	NADPH-dependent FMN reductase
GSR16_RS10830	COG1113	amino acid transport
GSR16_RS10850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GSR16_RS10870	COG3501	Rhs element vgr protein
GSR16_RS10895	COG2159	amidohydrolase
GSR16_RS10900	COG3384	dioxygenase
GSR16_RS10910	COG2828	Protein conserved in bacteria
GSR16_RS10915	COG0583	DNA-binding transcription factor activity
GSR16_RS10950	COG1473	amidohydrolase
GSR16_RS10955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSR16_RS10960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSR16_RS10990	COG2198	Histidine kinase
GSR16_RS10990	COG0784	Response regulator, receiver
GSR16_RS10990	COG2205	protein histidine kinase activity
GSR16_RS11005	COG0280	phosphate acetyltransferase
GSR16_RS11005	COG0281	malic enzyme
GSR16_RS11035	COG5002	protein histidine kinase activity
GSR16_RS11035	COG2205	protein histidine kinase activity
GSR16_RS11035	COG0784	Response regulator, receiver
GSR16_RS11045	COG3243	poly(R)-hydroxyalkanoic acid synthase
GSR16_RS11065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSR16_RS11100	COG0450	alkyl hydroperoxide reductase
GSR16_RS11105	COG2175	clavaminate synthase activity
GSR16_RS11110	COG0679	Auxin Efflux Carrier
GSR16_RS11120	COG0477	Major facilitator Superfamily
GSR16_RS11135	COG2814	Major facilitator Superfamily
GSR16_RS11150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSR16_RS11165	COG3501	Rhs element vgr protein
GSR16_RS11170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSR16_RS11195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSR16_RS11205	COG1082	Xylose isomerase domain protein TIM barrel
GSR16_RS11225	COG0667	Aldo Keto reductase
GSR16_RS11255	COG2159	amidohydrolase
GSR16_RS11260	COG2828	Protein conserved in bacteria
GSR16_RS11275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSR16_RS11280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GSR16_RS11285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSR16_RS11305	COG2822	iron ion transport
GSR16_RS11315	COG4773	Receptor
GSR16_RS11325	COG2203	Gaf domain
GSR16_RS11325	COG2199	diguanylate cyclase activity
GSR16_RS11330	COG2372	response to copper ion
GSR16_RS11335	COG1276	copper resistance
GSR16_RS11340	COG1064	alcohol dehydrogenase
GSR16_RS11345	COG2207	Transcriptional regulator
GSR16_RS11365	COG3706	GGDEF domain
GSR16_RS11370	COG2203	Gaf domain
GSR16_RS11370	COG2199	diguanylate cyclase activity
GSR16_RS11385	COG1959	2 iron, 2 sulfur cluster binding
GSR16_RS11395	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSR16_RS11425	COG0583	DNA-binding transcription factor activity
GSR16_RS11430	COG2814	Major facilitator Superfamily
GSR16_RS11455	COG2205	protein histidine kinase activity
GSR16_RS11455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS11470	COG0583	DNA-binding transcription factor activity
GSR16_RS11485	COG0583	DNA-binding transcription factor activity
GSR16_RS11545	COG0411	ABC transporter
GSR16_RS11555	COG0559	Belongs to the binding-protein-dependent transport system permease family
GSR16_RS11565	COG2072	flavoprotein involved in K transport
GSR16_RS11570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS11575	COG0765	amino acid transport
GSR16_RS11585	COG0410	ABC transporter
GSR16_RS11620	COG0431	NADPH-dependent FMN reductase
GSR16_RS11625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GSR16_RS11635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSR16_RS11655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSR16_RS11655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSR16_RS11675	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS11700	COG2011	ABC-type metal ion transport system permease component
GSR16_RS11730	COG4221	oxidoreductase activity
GSR16_RS11745	COG1733	regulation of RNA biosynthetic process
GSR16_RS11750	COG0583	DNA-binding transcription factor activity
GSR16_RS11755	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS11765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSR16_RS11770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSR16_RS11775	COG2113	Glycine betaine
GSR16_RS11780	COG4176	ABC-type proline glycine betaine transport system permease component
GSR16_RS11805	COG4319	ketosteroid isomerase
GSR16_RS11840	COG3501	Rhs element vgr protein
GSR16_RS11865	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GSR16_RS11940	COG3848	Pyruvate phosphate dikinase
GSR16_RS11940	COG0574	Belongs to the PEP-utilizing enzyme family
GSR16_RS11945	COG1309	transcriptional regulator
GSR16_RS11955	COG0702	epimerase
GSR16_RS11960	COG0300	oxidoreductase activity
GSR16_RS11985	COG1942	4-Oxalocrotonate Tautomerase
GSR16_RS12000	COG4569	acetaldehyde dehydrogenase (acetylating) activity
GSR16_RS12025	COG1538	Outer membrane efflux protein
GSR16_RS12035	COG1566	PFAM secretion protein HlyD family protein
GSR16_RS12040	COG3193	protein, possibly involved in utilization of glycolate and propanediol
GSR16_RS12060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSR16_RS12065	COG0583	DNA-binding transcription factor activity
GSR16_RS12070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GSR16_RS12080	COG1811	Na channel or pump
GSR16_RS12085	COG3787	Belongs to the UPF0306 family
GSR16_RS12095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSR16_RS12170	COG3596	GTP binding
GSR16_RS12200	COG3237	CsbD-like
GSR16_RS12215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GSR16_RS12280	COG1215	transferase activity, transferring glycosyl groups
GSR16_RS12285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GSR16_RS12295	COG2801	Transposase and inactivated derivatives
GSR16_RS12310	COG0583	DNA-binding transcription factor activity
GSR16_RS12325	COG4533	DNA binding
GSR16_RS12335	COG3311	Transcriptional regulator
GSR16_RS12355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSR16_RS12355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GSR16_RS12365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GSR16_RS12375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GSR16_RS12380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GSR16_RS12385	COG1024	Enoyl-CoA hydratase
GSR16_RS12395	COG0803	Belongs to the bacterial solute-binding protein 9 family
GSR16_RS12400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSR16_RS12405	COG1121	(ABC) transporter
GSR16_RS12415	COG0523	cobalamin synthesis protein
GSR16_RS12420	COG0735	belongs to the Fur family
GSR16_RS12440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GSR16_RS12450	COG3622	Belongs to the hyi family
GSR16_RS12455	COG0513	Belongs to the DEAD box helicase family
GSR16_RS12490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GSR16_RS12515	COG1522	sequence-specific DNA binding
GSR16_RS12520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GSR16_RS12530	COG1278	Cold shock
GSR16_RS12540	COG2957	Belongs to the agmatine deiminase family
GSR16_RS12550	COG0154	amidase activity
GSR16_RS12555	COG0006	proline dipeptidase activity
GSR16_RS12560	COG0018	arginyl-trna synthetase
GSR16_RS12565	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GSR16_RS12575	COG1177	transmembrane transport
GSR16_RS12580	COG1176	ABC-type spermidine putrescine transport system, permease component I
GSR16_RS12610	COG2833	Protein of unknown function (DUF455)
GSR16_RS12615	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GSR16_RS12620	COG2818	Glycosylase
GSR16_RS12630	COG0733	neurotransmitter:sodium symporter activity
GSR16_RS12665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GSR16_RS12670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GSR16_RS12675	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSR16_RS12685	COG5002	protein histidine kinase activity
GSR16_RS12685	COG5001	Diguanylate cyclase
GSR16_RS12690	COG5265	(ABC) transporter
GSR16_RS12695	COG2967	ApaG domain
GSR16_RS12700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GSR16_RS12705	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS12710	COG0546	phosphoglycolate phosphatase activity
GSR16_RS12725	COG1196	nuclear chromosome segregation
GSR16_RS12725	COG0739	heme binding
GSR16_RS12725	COG0741	lytic transglycosylase activity
GSR16_RS12735	COG0617	tRNA 3'-terminal CCA addition
GSR16_RS12750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSR16_RS12765	COG1360	Flagellar Motor Protein
GSR16_RS12780	COG0174	glutamine synthetase
GSR16_RS12785	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GSR16_RS12790	COG1917	Cupin 2, conserved barrel domain protein
GSR16_RS12790	COG1396	sequence-specific DNA binding
GSR16_RS12795	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS12800	COG0840	transmembrane signaling receptor activity
GSR16_RS12805	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GSR16_RS12810	COG1666	GTP binding
GSR16_RS12815	COG1737	Transcriptional regulator
GSR16_RS12815	COG0837	glucose binding
GSR16_RS12825	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS12830	COG1454	alcohol dehydrogenase
GSR16_RS12835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GSR16_RS12845	COG1280	lysine exporter protein (LysE YggA)
GSR16_RS12855	COG0137	argininosuccinate synthase activity
GSR16_RS12860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSR16_RS12870	COG1199	ATP-dependent helicase activity
GSR16_RS12885	COG0024	Methionine aminopeptidase
GSR16_RS12890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GSR16_RS12895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GSR16_RS12905	COG3411	Ferredoxin
GSR16_RS12910	COG0305	Participates in initiation and elongation during chromosome replication
GSR16_RS12915	COG2081	HI0933 family
GSR16_RS12920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GSR16_RS12925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSR16_RS12945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GSR16_RS12950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GSR16_RS12955	COG0740	serine-type endopeptidase activity
GSR16_RS12960	COG0544	peptidyl-prolyl cis-trans isomerase activity
GSR16_RS12975	COG0037	tRNA processing
GSR16_RS12980	COG0825	malonyl-CoA metabolic process
GSR16_RS13045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GSR16_RS13055	COG0312	modulator of DNA gyrase
GSR16_RS13060	COG3028	Belongs to the UPF0307 family
GSR16_RS13065	COG0521	Mo-molybdopterin cofactor biosynthetic process
GSR16_RS13070	COG0429	hydrolase of the alpha beta-hydrolase fold
GSR16_RS13075	COG0134	indole-3-glycerol-phosphate synthase activity
GSR16_RS13080	COG1752	Esterase of the alpha-beta hydrolase superfamily
GSR16_RS13090	COG0183	Belongs to the thiolase family
GSR16_RS13095	COG1024	Enoyl-CoA hydratase
GSR16_RS13095	COG1250	3-hydroxyacyl-CoA dehydrogenase
GSR16_RS13110	COG1960	acyl-CoA dehydrogenase activity
GSR16_RS13130	COG1286	toxin biosynthetic process
GSR16_RS13135	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GSR16_RS13140	COG0285	dihydrofolate synthase activity
GSR16_RS13160	COG0791	NLP P60 protein
GSR16_RS13190	COG0542	response to heat
GSR16_RS13205	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GSR16_RS13210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS13210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GSR16_RS13220	COG0730	response to heat
GSR16_RS13235	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GSR16_RS13240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GSR16_RS13245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GSR16_RS13250	COG2205	protein histidine kinase activity
GSR16_RS13255	COG0745	RESPONSE REGULATOR receiver
GSR16_RS13260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GSR16_RS13265	COG1181	Belongs to the D-alanine--D-alanine ligase family
GSR16_RS13280	COG2356	endonuclease I
GSR16_RS13295	COG2271	Major facilitator Superfamily
GSR16_RS13310	COG0183	Belongs to the thiolase family
GSR16_RS13320	COG0583	DNA-binding transcription factor activity
GSR16_RS13355	COG2814	Major facilitator Superfamily
GSR16_RS13360	COG2134	cdp-diacylglycerol pyrophosphatase
GSR16_RS13385	COG2223	nitrite transmembrane transporter activity
GSR16_RS13390	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS13395	COG0038	chloride channel
GSR16_RS13405	COG0501	Belongs to the peptidase M48B family
GSR16_RS13410	COG0583	DNA-binding transcription factor activity
GSR16_RS13425	COG0686	Belongs to the AlaDH PNT family
GSR16_RS13440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GSR16_RS13445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSR16_RS13450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GSR16_RS13455	COG0006	proline dipeptidase activity
GSR16_RS13460	COG0217	transcriptional regulatory protein
GSR16_RS13465	COG1684	flagellar biosynthetic protein fliR
GSR16_RS13470	COG1987	bacterial-type flagellum assembly
GSR16_RS13490	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GSR16_RS13520	COG3842	ATPase activity
GSR16_RS13530	COG1157	protein secretion by the type III secretion system
GSR16_RS13545	COG1766	The M ring may be actively involved in energy transduction
GSR16_RS13550	COG1677	Flagellar hook-basal body complex protein FliE
GSR16_RS13555	COG2204	response regulator
GSR16_RS13560	COG2201	protein-glutamate methylesterase activity
GSR16_RS13565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSR16_RS13570	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GSR16_RS13590	COG0583	DNA-binding transcription factor activity
GSR16_RS13600	COG0556	nucleotide-excision repair
GSR16_RS13645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSR16_RS13655	COG0531	amino acid
GSR16_RS13660	COG4303	Ethanolamine ammonia lyase large subunit
GSR16_RS13665	COG4302	ethanolamine ammonia-lyase activity
GSR16_RS13685	COG0784	Response regulator, receiver
GSR16_RS13685	COG0835	chemotaxis
GSR16_RS13690	COG0784	Response regulator, receiver
GSR16_RS13690	COG0835	chemotaxis
GSR16_RS13695	COG0745	RESPONSE REGULATOR receiver
GSR16_RS13700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GSR16_RS13715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSR16_RS13730	COG1538	Outer membrane efflux protein
GSR16_RS13735	COG0697	spore germination
GSR16_RS13745	COG2902	Dehydrogenase
GSR16_RS13760	COG4215	(ABC) transporter
GSR16_RS13780	COG4191	Histidine kinase
GSR16_RS13810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GSR16_RS13835	COG0280	phosphate acetyltransferase
GSR16_RS13835	COG0281	malic enzyme
GSR16_RS13845	COG2990	Protein conserved in bacteria
GSR16_RS13850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GSR16_RS13860	COG4178	(ABC) transporter
GSR16_RS13870	COG1522	sequence-specific DNA binding
GSR16_RS13870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSR16_RS13875	COG2313	pseudouridylate synthase activity
GSR16_RS13880	COG1418	mRNA catabolic process
GSR16_RS13890	COG1464	Belongs to the NlpA lipoprotein family
GSR16_RS13895	COG2011	ABC-type metal ion transport system permease component
GSR16_RS13905	COG3568	Endonuclease Exonuclease Phosphatase
GSR16_RS13925	COG0671	phosphoesterase, PA-phosphatase related
GSR16_RS13940	COG4566	intracellular signal transduction
GSR16_RS13945	COG1511	domain protein
GSR16_RS13945	COG3264	Mechanosensitive ion channel
GSR16_RS13950	COG1136	(ABC) transporter
GSR16_RS13965	COG0791	NLP P60 protein
GSR16_RS13990	COG1595	DNA-templated transcription, initiation
GSR16_RS14005	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS14010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GSR16_RS14020	COG1562	ergosterol biosynthetic process
GSR16_RS14055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSR16_RS14075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GSR16_RS14080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GSR16_RS14085	COG1376	ErfK ybiS ycfS ynhG family protein
GSR16_RS14090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSR16_RS14120	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS14125	COG1177	transmembrane transport
GSR16_RS14130	COG1176	ABC-type spermidine putrescine transport system, permease component I
GSR16_RS14135	COG3842	ATPase activity
GSR16_RS14140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GSR16_RS14145	COG0583	DNA-binding transcription factor activity
GSR16_RS14155	COG1530	ribonuclease E activity
GSR16_RS14180	COG1360	Flagellar Motor Protein
GSR16_RS14190	COG0167	dihydroorotate dehydrogenase activity
GSR16_RS14200	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GSR16_RS14205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GSR16_RS14215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GSR16_RS14220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GSR16_RS14225	COG2719	SpoVR family
GSR16_RS14230	COG2718	Belongs to the UPF0229 family
GSR16_RS14235	COG2766	serine protein kinase
GSR16_RS14245	COG0494	nUDIX hydrolase
GSR16_RS14255	COG1960	acyl-CoA dehydrogenase activity
GSR16_RS14260	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS14280	COG3618	amidohydrolase
GSR16_RS14285	COG3254	rhamnose metabolic process
GSR16_RS14290	COG4948	Mandelate Racemase Muconate Lactonizing
GSR16_RS14300	COG3012	SEC-C Motif Domain Protein
GSR16_RS14300	COG3318	Belongs to the UPF0149 family
GSR16_RS14305	COG0318	PFAM AMP-dependent synthetase and ligase
GSR16_RS14315	COG1960	acyl-CoA dehydrogenase activity
GSR16_RS14320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GSR16_RS14340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSR16_RS14355	COG0254	rRNA binding
GSR16_RS14360	COG0215	cysteine-tRNA ligase activity
GSR16_RS14365	COG0205	6-phosphofructokinase activity
GSR16_RS14370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSR16_RS14380	COG1032	radical SAM domain protein
GSR16_RS14385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GSR16_RS14390	COG0659	secondary active sulfate transmembrane transporter activity
GSR16_RS14405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GSR16_RS14410	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GSR16_RS14415	COG0840	transmembrane signaling receptor activity
GSR16_RS14420	COG1620	l-lactate permease
GSR16_RS14425	COG1802	Transcriptional regulator
GSR16_RS14430	COG0246	Mannitol dehydrogenase
GSR16_RS14435	COG0477	Major facilitator Superfamily
GSR16_RS14440	COG1063	alcohol dehydrogenase
GSR16_RS14445	COG4948	Mandelate Racemase Muconate Lactonizing
GSR16_RS14450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GSR16_RS14460	COG0583	DNA-binding transcription factor activity
GSR16_RS14465	COG3162	membrane
GSR16_RS14475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSR16_RS14480	COG3781	membrane
GSR16_RS14495	COG2878	Part of a membrane complex involved in electron transport
GSR16_RS14510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GSR16_RS14515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSR16_RS14520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GSR16_RS14530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GSR16_RS14535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GSR16_RS14540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GSR16_RS14555	COG0617	tRNA 3'-terminal CCA addition
GSR16_RS14570	COG0534	Mate efflux family protein
GSR16_RS14575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GSR16_RS14600	COG3706	GGDEF domain
GSR16_RS14600	COG0745	RESPONSE REGULATOR receiver
GSR16_RS14615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GSR16_RS14625	COG4172	Belongs to the ABC transporter superfamily
GSR16_RS14630	COG4239	(ABC) transporter, permease
GSR16_RS14635	COG4174	ABC transporter (Permease)
GSR16_RS14640	COG4166	transmembrane transport
GSR16_RS14655	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS14665	COG1846	Transcriptional regulator
GSR16_RS14675	COG1113	amino acid transport
GSR16_RS14690	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS14695	COG2207	Transcriptional regulator
GSR16_RS14715	COG1012	belongs to the aldehyde dehydrogenase family
GSR16_RS14720	COG3384	dioxygenase
GSR16_RS14730	COG2814	Major facilitator Superfamily
GSR16_RS14740	COG3971	2-oxopent-4-enoate hydratase activity
GSR16_RS14760	COG1960	acyl-CoA dehydrogenase activity
GSR16_RS14765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GSR16_RS14770	COG0784	Response regulator, receiver
GSR16_RS14770	COG2205	protein histidine kinase activity
GSR16_RS14770	COG2198	Histidine kinase
GSR16_RS14770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS14785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GSR16_RS14795	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GSR16_RS14795	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GSR16_RS14795	COG0506	proline dehydrogenase activity
GSR16_RS14800	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GSR16_RS14810	COG2204	response regulator
GSR16_RS14820	COG2205	protein histidine kinase activity
GSR16_RS14850	COG0557	exoribonuclease II activity
GSR16_RS14870	COG0477	Major facilitator Superfamily
GSR16_RS14885	COG4702	Belongs to the UPF0303 family
GSR16_RS14890	COG0673	inositol 2-dehydrogenase activity
GSR16_RS14895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GSR16_RS14900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GSR16_RS14905	COG0330	HflC and HflK could
GSR16_RS14910	COG0330	HflC and HflK could
GSR16_RS14915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GSR16_RS14920	COG1923	regulation of RNA biosynthetic process
GSR16_RS14925	COG1160	GTP binding
GSR16_RS14930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GSR16_RS14940	COG0124	histidyl-tRNA synthetase
GSR16_RS14945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GSR16_RS14950	COG1426	Protein conserved in bacteria
GSR16_RS14960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GSR16_RS14965	COG0105	UTP biosynthetic process
GSR16_RS14980	COG3718	enzyme involved in inositol metabolism
GSR16_RS15005	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSR16_RS15010	COG1129	ABC transporter
GSR16_RS15025	COG3962	Belongs to the TPP enzyme family
GSR16_RS15030	COG1609	Transcriptional regulator
GSR16_RS15035	COG1082	Xylose isomerase domain protein TIM barrel
GSR16_RS15045	COG0673	inositol 2-dehydrogenase activity
GSR16_RS15050	COG0673	inositol 2-dehydrogenase activity
GSR16_RS15055	COG0673	inositol 2-dehydrogenase activity
GSR16_RS15075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSR16_RS15080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSR16_RS15110	COG1047	Peptidyl-prolyl cis-trans
GSR16_RS15135	COG0582	viral genome integration into host DNA
GSR16_RS15185	COG2974	May be involved in recombination
GSR16_RS15195	COG3384	dioxygenase
GSR16_RS15200	COG0167	dihydroorotate dehydrogenase activity
GSR16_RS15205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GSR16_RS15215	COG0717	Belongs to the dCTP deaminase family
GSR16_RS15225	COG3012	SEC-C Motif Domain Protein
GSR16_RS15240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSR16_RS15245	COG1929	Belongs to the glycerate kinase type-1 family
GSR16_RS15260	COG1448	Aminotransferase
GSR16_RS15275	COG3539	Fimbrial protein
GSR16_RS15290	COG3188	usher protein
GSR16_RS15295	COG3188	usher protein
GSR16_RS15335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GSR16_RS15340	COG0322	excinuclease ABC activity
GSR16_RS15375	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GSR16_RS15385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GSR16_RS15385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GSR16_RS15390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GSR16_RS15395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSR16_RS15405	COG0625	glutathione transferase activity
GSR16_RS15410	COG0129	dihydroxy-acid dehydratase activity
GSR16_RS15415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GSR16_RS15420	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GSR16_RS15430	COG3639	organic phosphonate transmembrane transporter activity
GSR16_RS15435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS15440	COG0765	amino acid transport
GSR16_RS15445	COG0765	amino acid transport
GSR16_RS15465	COG2217	Heavy metal translocating P-type atpase
GSR16_RS15470	COG0598	Magnesium transport protein CorA
GSR16_RS15475	COG0248	Ppx GppA phosphatase
GSR16_RS15480	COG0704	Plays a role in the regulation of phosphate uptake
GSR16_RS15485	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GSR16_RS15490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GSR16_RS15495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GSR16_RS15505	COG0328	RNA-DNA hybrid ribonuclease activity
GSR16_RS15510	COG2226	methyltransferase
GSR16_RS15515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSR16_RS15520	COG0741	lytic transglycosylase activity
GSR16_RS15520	COG1388	LysM domain
GSR16_RS15525	COG1490	D-aminoacyl-tRNA deacylase activity
GSR16_RS15530	COG0384	phenazine biosynthesis protein PhzF
GSR16_RS15535	COG3022	response to hydroperoxide
GSR16_RS15540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSR16_RS15560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSR16_RS15560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSR16_RS15570	COG0489	protein tyrosine kinase activity
GSR16_RS15590	COG0436	Aminotransferase
GSR16_RS15605	COG2169	Transcriptional regulator
GSR16_RS15605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSR16_RS15610	COG3145	DNA-N1-methyladenine dioxygenase activity
GSR16_RS15615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GSR16_RS15620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSR16_RS15630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GSR16_RS15645	COG0308	aminopeptidase N
GSR16_RS15655	COG3278	Belongs to the heme-copper respiratory oxidase family
GSR16_RS15690	COG3033	Beta-eliminating lyase
GSR16_RS15700	COG3104	oligopeptide transport
GSR16_RS15705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GSR16_RS15710	COG0463	Glycosyl transferase, family 2
GSR16_RS15725	COG0564	pseudouridine synthase activity
GSR16_RS15730	COG1607	acyl-coa hydrolase
GSR16_RS15740	COG1346	cytolysis
GSR16_RS15745	COG1380	Effector of murein hydrolase LrgA
GSR16_RS15750	COG0583	DNA-binding transcription factor activity
GSR16_RS15770	COG0045	succinate-CoA ligase (ADP-forming) activity
GSR16_RS15775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSR16_RS15785	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSR16_RS15790	COG0567	Dehydrogenase, E1 component
GSR16_RS15800	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GSR16_RS15805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GSR16_RS15820	COG2009	succinate dehydrogenase
GSR16_RS15830	COG0039	L-malate dehydrogenase activity
GSR16_RS15840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GSR16_RS15910	COG0210	DNA helicase
GSR16_RS15930	COG0402	S-adenosylhomocysteine deaminase activity
GSR16_RS15935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GSR16_RS15950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GSR16_RS15955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GSR16_RS15960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GSR16_RS15975	COG1191	sigma factor activity
GSR16_RS15980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GSR16_RS15985	COG1199	ATP-dependent helicase activity
GSR16_RS15985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GSR16_RS16015	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GSR16_RS16020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GSR16_RS16030	COG0583	DNA-binding transcription factor activity
GSR16_RS16045	COG0850	regulation of cytokinetic process
GSR16_RS16055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GSR16_RS16060	COG0583	DNA-binding transcription factor activity
GSR16_RS16065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSR16_RS16085	COG1187	pseudouridine synthase activity
GSR16_RS16090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GSR16_RS16100	COG0583	DNA-binding transcription factor activity
GSR16_RS16110	COG0180	Tryptophanyl-tRNA synthetase
GSR16_RS16115	COG1994	Peptidase M50
GSR16_RS16120	COG0009	L-threonylcarbamoyladenylate synthase
GSR16_RS16125	COG0613	PHP domain protein
GSR16_RS16145	COG0252	asparaginase activity
GSR16_RS16160	COG2188	Transcriptional regulator
GSR16_RS16180	COG3842	ATPase activity
GSR16_RS16200	COG0861	Integral membrane protein TerC family
GSR16_RS16205	COG1914	H( )-stimulated, divalent metal cation uptake system
GSR16_RS16210	COG0330	HflC and HflK could
GSR16_RS16215	COG0330	HflC and HflK could
GSR16_RS16245	COG0583	DNA-binding transcription factor activity
GSR16_RS16270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GSR16_RS16280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GSR16_RS16285	COG1137	ATPase activity
GSR16_RS16290	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GSR16_RS16295	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GSR16_RS16305	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GSR16_RS16310	COG1660	Displays ATPase and GTPase activities
GSR16_RS16330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS16330	COG4191	Histidine kinase
GSR16_RS16335	COG0784	Response regulator, receiver
GSR16_RS16335	COG3437	response regulator, receiver
GSR16_RS16340	COG1272	protein, Hemolysin III
GSR16_RS16345	COG0563	adenylate kinase activity
GSR16_RS16350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GSR16_RS16355	COG2835	tetraacyldisaccharide 4'-kinase activity
GSR16_RS16360	COG1663	tetraacyldisaccharide 4'-kinase activity
GSR16_RS16365	COG0848	biopolymer transport protein
GSR16_RS16370	COG0811	peptide transport
GSR16_RS16375	COG1570	exodeoxyribonuclease VII activity
GSR16_RS16385	COG0640	Transcriptional regulator
GSR16_RS16390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GSR16_RS16395	COG4942	peptidase
GSR16_RS16400	COG0793	Belongs to the peptidase S41A family
GSR16_RS16405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GSR16_RS16405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GSR16_RS16410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GSR16_RS16425	COG0488	(ABC) transporter
GSR16_RS16440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GSR16_RS16465	COG0527	aspartate kinase activity
GSR16_RS16470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GSR16_RS16480	COG0437	4 iron, 4 sulfur cluster binding
GSR16_RS16485	COG2864	formate dehydrogenase
GSR16_RS16505	COG2198	Histidine kinase
GSR16_RS16505	COG0643	Histidine kinase
GSR16_RS16520	COG0835	chemotaxis
GSR16_RS16525	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GSR16_RS16530	COG2201	protein-glutamate methylesterase activity
GSR16_RS16535	COG5001	Diguanylate cyclase
GSR16_RS16535	COG4251	negative regulation of phosphorylation
GSR16_RS16535	COG2203	Gaf domain
GSR16_RS16535	COG3706	GGDEF domain
GSR16_RS16550	COG1921	L-seryl-tRNASec selenium transferase activity
GSR16_RS16560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GSR16_RS16565	COG3276	selenocysteine insertion sequence binding
GSR16_RS16585	COG0247	lactate metabolic process
GSR16_RS16590	COG1139	Iron-sulfur cluster binding protein
GSR16_RS16600	COG0513	Belongs to the DEAD box helicase family
GSR16_RS16605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GSR16_RS16645	COG0436	Aminotransferase
GSR16_RS16665	COG2610	gluconate transmembrane transporter activity
GSR16_RS16670	COG1028	Short-chain dehydrogenase reductase Sdr
GSR16_RS16685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GSR16_RS16700	COG2226	methyltransferase
GSR16_RS16710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GSR16_RS16715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GSR16_RS16720	COG0511	ligase activity, forming carbon-carbon bonds
GSR16_RS16725	COG0439	Biotin carboxylase
GSR16_RS16730	COG2264	protein methyltransferase activity
GSR16_RS16750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GSR16_RS16760	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GSR16_RS16775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GSR16_RS16780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GSR16_RS16800	COG0583	DNA-binding transcription factor activity
GSR16_RS16820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GSR16_RS16835	COG0019	diaminopimelate decarboxylase activity
GSR16_RS16840	COG0583	DNA-binding transcription factor activity
GSR16_RS16845	COG0840	transmembrane signaling receptor activity
GSR16_RS16865	COG1301	dicarboxylic acid transport
GSR16_RS16890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GSR16_RS16895	COG2022	thiamine diphosphate biosynthetic process
GSR16_RS16905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GSR16_RS16910	COG1758	RNA polymerase activity
GSR16_RS16915	COG0194	GDP metabolic process
GSR16_RS16920	COG2252	PERMEase
GSR16_RS16925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSR16_RS16935	COG1695	Transcriptional regulator
GSR16_RS16950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSR16_RS16955	COG2235	arginine
GSR16_RS16970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSR16_RS16970	COG0543	2 iron, 2 sulfur cluster binding
GSR16_RS16980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GSR16_RS16985	COG0386	Belongs to the glutathione peroxidase family
GSR16_RS16995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSR16_RS17010	COG0586	Pfam SNARE associated Golgi protein
GSR16_RS17015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GSR16_RS17020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSR16_RS17030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GSR16_RS17035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GSR16_RS17040	COG1534	Rna-binding protein
GSR16_RS17070	COG1960	acyl-CoA dehydrogenase activity
GSR16_RS17085	COG2030	dehydratase
GSR16_RS17100	COG0802	atpase or kinase
GSR16_RS17105	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSR16_RS17110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GSR16_RS17115	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GSR16_RS17120	COG0237	dephospho-CoA kinase activity
GSR16_RS17145	COG0415	Belongs to the DNA photolyase family
GSR16_RS17150	COG1596	polysaccharide export
GSR16_RS17150	COG1555	photosystem II stabilization
GSR16_RS17160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GSR16_RS17180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GSR16_RS17200	COG0347	Belongs to the P(II) protein family
GSR16_RS17205	COG0004	ammonium transporteR
GSR16_RS17210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GSR16_RS17220	COG1560	Kdo2-lipid A biosynthetic process
GSR16_RS17230	COG1007	ATP synthesis coupled electron transport
GSR16_RS17245	COG0713	ATP synthesis coupled electron transport
GSR16_RS17255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSR16_RS17260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GSR16_RS17265	COG1034	ATP synthesis coupled electron transport
GSR16_RS17275	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GSR16_RS17280	COG0649	NAD binding
GSR16_RS17285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSR16_RS17290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSR16_RS17295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GSR16_RS17305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSR16_RS17310	COG0149	triose-phosphate isomerase activity
GSR16_RS17325	COG0581	inorganic phosphate transmembrane transporter activity
GSR16_RS17330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSR16_RS17335	COG0306	phosphate transporter
GSR16_RS17340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GSR16_RS17365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSR16_RS17370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GSR16_RS17380	COG0109	protoheme IX farnesyltransferase activity
GSR16_RS17400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GSR16_RS17405	COG0840	transmembrane signaling receptor activity
GSR16_RS17410	COG0745	RESPONSE REGULATOR receiver
GSR16_RS17415	COG2205	protein histidine kinase activity
GSR16_RS17425	COG3591	Belongs to the peptidase S1B family
GSR16_RS17430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GSR16_RS17435	COG0631	protein serine/threonine phosphatase activity
GSR16_RS17440	COG2815	serine threonine protein kinase
GSR16_RS17440	COG0515	serine threonine protein kinase
GSR16_RS17445	COG1561	YicC-like family, N-terminal region
GSR16_RS17470	COG3813	Protein conserved in bacteria
GSR16_RS17475	COG2084	Dehydrogenase
GSR16_RS17480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GSR16_RS17515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GSR16_RS17520	COG1216	Glycosyl transferase, family 2
GSR16_RS17520	COG0438	transferase activity, transferring glycosyl groups
GSR16_RS17525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSR16_RS17575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GSR16_RS17580	COG1678	Uncharacterized ACR, COG1678
GSR16_RS17590	COG2223	nitrite transmembrane transporter activity
GSR16_RS17605	COG2353	YceI-like domain
GSR16_RS17610	COG3038	cytochrome b561
GSR16_RS17615	COG1846	Transcriptional regulator
GSR16_RS17620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GSR16_RS17630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GSR16_RS17640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSR16_RS17655	COG0477	Major facilitator Superfamily
GSR16_RS17660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GSR16_RS17665	COG3530	Putative quorum-sensing-regulated virulence factor
GSR16_RS17695	COG1414	Transcriptional regulator
GSR16_RS17710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GSR16_RS17725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSR16_RS17730	COG1538	Outer membrane efflux protein
GSR16_RS17735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GSR16_RS17765	COG1683	Conserved Protein
GSR16_RS17800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GSR16_RS17805	COG0514	ATP-dependent DNA helicase (RecQ)
GSR16_RS17815	COG1192	Involved in chromosome partitioning
GSR16_RS17820	COG2205	protein histidine kinase activity
GSR16_RS17835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GSR16_RS17850	COG2900	Belongs to the SlyX family
GSR16_RS17870	COG2171	N-acyltransferase activity
GSR16_RS17875	COG1127	ABC transporter
GSR16_RS17880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GSR16_RS17885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GSR16_RS17910	COG0840	transmembrane signaling receptor activity
GSR16_RS17915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSR16_RS17920	COG0271	Belongs to the BolA IbaG family
GSR16_RS17925	COG0842	Transport permease protein
GSR16_RS17930	COG1131	(ABC) transporter
GSR16_RS17970	COG3047	cAMP biosynthetic process
GSR16_RS17975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GSR16_RS17980	COG3171	Protein conserved in bacteria
GSR16_RS18000	COG1027	Aspartate ammonia-lyase
GSR16_RS18005	COG0406	alpha-ribazole phosphatase activity
GSR16_RS18010	COG0583	DNA-binding transcription factor activity
GSR16_RS18015	COG3706	GGDEF domain
GSR16_RS18025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GSR16_RS18030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GSR16_RS18050	COG0297	glycogen (starch) synthase activity
GSR16_RS18095	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GSR16_RS18100	COG0037	tRNA processing
GSR16_RS18130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GSR16_RS18135	COG1187	pseudouridine synthase activity
GSR16_RS18155	COG1879	ABC-type sugar transport system periplasmic component
GSR16_RS18160	COG1172	Belongs to the binding-protein-dependent transport system permease family
GSR16_RS18165	COG1129	ABC transporter
GSR16_RS18170	COG1869	D-ribose catabolic process
GSR16_RS18175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSR16_RS18185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSR16_RS18200	COG1702	phosphate starvation-inducible protein PhoH
GSR16_RS18205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GSR16_RS18210	COG4535	Mg2 and Co2 transporter CorC
GSR16_RS18215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GSR16_RS18220	COG0840	transmembrane signaling receptor activity
GSR16_RS18225	COG0633	Ferredoxin
GSR16_RS18225	COG3217	Mosc domain protein beta barrel domain protein
GSR16_RS18230	COG0203	ribosomal protein L17
GSR16_RS18235	COG0202	RNA polymerase activity
GSR16_RS18240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GSR16_RS18245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GSR16_RS18250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GSR16_RS18255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GSR16_RS18260	COG0201	protein transport
GSR16_RS18265	COG0200	Binds to the 23S rRNA
GSR16_RS18270	COG1841	ribosomal large subunit assembly
GSR16_RS18275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GSR16_RS18280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GSR16_RS18285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GSR16_RS18290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GSR16_RS18295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GSR16_RS18300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GSR16_RS18305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GSR16_RS18310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GSR16_RS18315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GSR16_RS18320	COG0255	Belongs to the universal ribosomal protein uL29 family
GSR16_RS18325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GSR16_RS18330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GSR16_RS18335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GSR16_RS18340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GSR16_RS18345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GSR16_RS18350	COG0089	rRNA binding
GSR16_RS18355	COG0088	Forms part of the polypeptide exit tunnel
GSR16_RS18360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GSR16_RS18365	COG0051	transcription antitermination factor activity, RNA binding
GSR16_RS18370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GSR16_RS18375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GSR16_RS18380	COG0049	tRNA binding
GSR16_RS18385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GSR16_RS18390	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GSR16_RS18395	COG0085	RNA polymerase activity
GSR16_RS18400	COG0222	ribosome binding
GSR16_RS18405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GSR16_RS18415	COG0081	regulation of translation
GSR16_RS18420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GSR16_RS18440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GSR16_RS18460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GSR16_RS18465	COG0742	ribosomal rna small subunit methyltransferase
GSR16_RS18475	COG0612	Peptidase, M16
GSR16_RS18485	COG2884	Cell division ATP-binding protein ftsE
GSR16_RS18495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSR16_RS18500	COG3307	-O-antigen
GSR16_RS18510	COG4969	Belongs to the N-Me-Phe pilin family
GSR16_RS18530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GSR16_RS18540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GSR16_RS18540	COG0519	Catalyzes the synthesis of GMP from XMP
GSR16_RS18545	COG2255	four-way junction helicase activity
GSR16_RS18550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSR16_RS18555	COG0632	four-way junction helicase activity
GSR16_RS18565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GSR16_RS18580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GSR16_RS18585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSR16_RS18590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GSR16_RS18600	COG0625	glutathione transferase activity
GSR16_RS18610	COG1253	flavin adenine dinucleotide binding
GSR16_RS18635	COG0708	Exodeoxyribonuclease III
GSR16_RS18640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GSR16_RS18685	COG1324	tolerance protein
GSR16_RS18695	COG1872	DUF167
GSR16_RS18700	COG0783	Belongs to the Dps family
GSR16_RS18715	COG0824	Thioesterase
GSR16_RS18720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSR16_RS18725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GSR16_RS18730	COG2204	response regulator
GSR16_RS18735	COG5000	phosphorelay sensor kinase activity
GSR16_RS18750	COG0501	Belongs to the peptidase M48B family
GSR16_RS18755	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSR16_RS18760	COG0242	peptide deformylase activity
GSR16_RS18770	COG0758	DNA mediated transformation
GSR16_RS18775	COG2922	Belongs to the Smg family
GSR16_RS18805	COG0189	ligase activity
GSR16_RS18825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSR16_RS18830	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSR16_RS18830	COG1902	pentaerythritol trinitrate reductase activity
GSR16_RS18840	COG2267	carboxylic ester hydrolase activity
GSR16_RS18850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSR16_RS18855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GSR16_RS18865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GSR16_RS18880	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GSR16_RS18885	COG2885	chlorophyll binding
GSR16_RS18890	COG0823	Involved in the tonB-independent uptake of proteins
GSR16_RS18930	COG0210	DNA helicase
GSR16_RS18945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GSR16_RS18965	COG1045	serine acetyltransferase
GSR16_RS18970	COG1530	ribonuclease E activity
GSR16_RS18975	COG0424	maF-like protein
GSR16_RS18980	COG0653	protein targeting
GSR16_RS18990	COG1116	anion transmembrane transporter activity
GSR16_RS19000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GSR16_RS19005	COG4208	sulfate ABC transporter
GSR16_RS19010	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GSR16_RS19025	COG0840	transmembrane signaling receptor activity
GSR16_RS19030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSR16_RS19050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GSR16_RS19075	COG0174	glutamine synthetase
GSR16_RS19080	COG0405	Gamma-glutamyltransferase
GSR16_RS19090	COG0589	response to stress
GSR16_RS19100	COG3132	Protein of unknown function, DUF480
GSR16_RS19120	COG1505	serine-type exopeptidase activity
GSR16_RS19145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GSR16_RS19150	COG0501	Belongs to the peptidase M48B family
GSR16_RS19155	COG4608	Belongs to the ABC transporter superfamily
GSR16_RS19165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSR16_RS19170	COG0601	transmembrane transport
GSR16_RS19175	COG4166	transmembrane transport
GSR16_RS19180	COG0418	dihydroorotase activity
GSR16_RS19210	COG0315	cyclic pyranopterin monophosphate synthase activity
GSR16_RS19220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GSR16_RS19235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GSR16_RS19240	COG1181	Belongs to the D-alanine--D-alanine ligase family
GSR16_RS19245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GSR16_RS19250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSR16_RS19255	COG0772	Belongs to the SEDS family
GSR16_RS19260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GSR16_RS19265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSR16_RS19270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GSR16_RS19275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GSR16_RS19285	COG3116	cell division
GSR16_RS19290	COG0275	rRNA processing
GSR16_RS19295	COG2001	Belongs to the MraZ family
GSR16_RS19300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSR16_RS19305	COG0154	amidase activity
GSR16_RS19310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSR16_RS19315	COG1077	Cell shape determining protein MreB Mrl
GSR16_RS19320	COG1792	Involved in formation and maintenance of cell shape
GSR16_RS19325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GSR16_RS19330	COG0768	penicillin binding
GSR16_RS19335	COG0772	Belongs to the SEDS family
GSR16_RS19350	COG3791	Glutathione-dependent formaldehyde-activating
GSR16_RS19365	COG2847	Copper chaperone PCu(A)C
GSR16_RS19375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSR16_RS19380	COG0625	glutathione transferase activity
GSR16_RS19385	COG1752	Esterase of the alpha-beta hydrolase superfamily
GSR16_RS19390	COG2226	methyltransferase
GSR16_RS19395	COG2267	carboxylic ester hydrolase activity
GSR16_RS19405	COG0156	8-amino-7-oxononanoate synthase activity
GSR16_RS19410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GSR16_RS19415	COG1040	competence protein
GSR16_RS19420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GSR16_RS19430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GSR16_RS19435	COG2010	Cytochrome c
GSR16_RS19440	COG1333	cytochrome c biogenesis protein
GSR16_RS19445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GSR16_RS19450	COG1253	flavin adenine dinucleotide binding
GSR16_RS19465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSR16_RS19480	COG0166	Belongs to the GPI family
GSR16_RS19490	COG0837	glucose binding
GSR16_RS19500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GSR16_RS19505	COG0129	dihydroxy-acid dehydratase activity
GSR16_RS19510	COG0800	Aldolase
GSR16_RS19520	COG2205	protein histidine kinase activity
GSR16_RS19535	COG0395	ABC-type sugar transport system, permease component
GSR16_RS19540	COG3842	ATPase activity
GSR16_RS19545	COG4989	oxidoreductase activity
GSR16_RS19555	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GSR16_RS19560	COG3706	GGDEF domain
GSR16_RS19560	COG0745	RESPONSE REGULATOR receiver
GSR16_RS19575	COG2200	EAL domain
GSR16_RS19580	COG0165	Argininosuccinate lyase
GSR16_RS19595	COG3275	phosphorelay sensor kinase activity
GSR16_RS19620	COG0028	Belongs to the TPP enzyme family
GSR16_RS19625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GSR16_RS19630	COG0181	hydroxymethylbilane synthase activity
GSR16_RS19640	COG2959	enzyme of heme biosynthesis
GSR16_RS19655	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GSR16_RS19660	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GSR16_RS19665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GSR16_RS19675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GSR16_RS19680	COG0706	membrane insertase activity
GSR16_RS19685	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GSR16_RS19690	COG0594	ribonuclease P activity
GSR16_RS19695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GSR16_RS19700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GSR16_RS19745	COG1858	cytochrome C peroxidase
GSR16_RS19770	COG5001	Diguanylate cyclase
GSR16_RS19770	COG3706	GGDEF domain
GSR16_RS19770	COG2203	Gaf domain
GSR16_RS19770	COG4251	negative regulation of phosphorylation
GSR16_RS19780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSR16_RS19790	COG1132	(ABC) transporter
GSR16_RS19815	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GSR16_RS19820	COG0583	DNA-binding transcription factor activity
GSR16_RS19825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GSR16_RS19850	COG0259	pyridoxamine-phosphate oxidase activity
GSR16_RS19855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GSR16_RS19860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GSR16_RS19865	COG0583	DNA-binding transcription factor activity
GSR16_RS19870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS19870	COG2205	protein histidine kinase activity
GSR16_RS19875	COG2201	protein-glutamate methylesterase activity
GSR16_RS19925	COG2153	protein acetylation
GSR16_RS19935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GSR16_RS19940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GSR16_RS19945	COG0126	phosphoglycerate kinase activity
GSR16_RS19950	COG1280	lysine exporter protein (LysE YggA)
GSR16_RS19965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GSR16_RS19970	COG0314	molybdopterin synthase activity
GSR16_RS19975	COG0746	molybdenum cofactor guanylyltransferase activity
GSR16_RS19980	COG0583	DNA-binding transcription factor activity
GSR16_RS19990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GSR16_RS19995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GSR16_RS20000	COG4654	Cytochrome c, class I
GSR16_RS20005	COG0762	integral membrane protein
GSR16_RS20035	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GSR16_RS20040	COG1126	abc transporter atp-binding protein
GSR16_RS20045	COG0765	amino acid transport
GSR16_RS20050	COG0765	amino acid transport
GSR16_RS20055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GSR16_RS20060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GSR16_RS20065	COG1238	metal cluster binding
GSR16_RS20080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSR16_RS20100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GSR16_RS20105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSR16_RS20120	COG4783	chaperone-mediated protein folding
GSR16_RS20125	COG1773	rubredoxin
GSR16_RS20130	COG0351	phosphomethylpyrimidine kinase
GSR16_RS20135	COG0352	thiamine-phosphate diphosphorylase activity
GSR16_RS20140	COG0583	DNA-binding transcription factor activity
GSR16_RS20155	COG0842	Transport permease protein
GSR16_RS20160	COG0842	Transport permease protein
GSR16_RS20165	COG1131	(ABC) transporter
GSR16_RS20170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GSR16_RS20180	COG1519	Transferase
GSR16_RS20185	COG0859	PFAM glycosyl transferase family 9
GSR16_RS20210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GSR16_RS20210	COG4651	solute:proton antiporter activity
GSR16_RS20215	COG1253	flavin adenine dinucleotide binding
GSR16_RS20220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GSR16_RS20230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GSR16_RS20235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GSR16_RS20240	COG1953	Uracil, thiamine, allantoin
GSR16_RS20255	COG3214	Protein conserved in bacteria
GSR16_RS20265	COG0826	peptidase U32
GSR16_RS20295	COG4628	conserved protein (DUF2132)
GSR16_RS20310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GSR16_RS20315	COG0668	transmembrane transport
GSR16_RS20335	COG0540	Belongs to the ATCase OTCase family
GSR16_RS20340	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GSR16_RS20345	COG1247	-acetyltransferase
GSR16_RS20380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSR16_RS20405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GSR16_RS20415	COG0676	glucose-6-phosphate 1-epimerase activity
GSR16_RS20420	COG2188	Transcriptional regulator
GSR16_RS20425	COG1968	undecaprenyl-diphosphatase activity
GSR16_RS20430	COG1228	amidohydrolase
GSR16_RS20435	COG0010	Belongs to the arginase family
GSR16_RS20440	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GSR16_RS20445	COG2986	histidine ammonia-lyase
GSR16_RS20450	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GSR16_RS20460	COG1573	uracil-dna glycosylase
GSR16_RS20515	COG0469	pyruvate kinase activity
GSR16_RS20525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GSR16_RS20530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GSR16_RS20570	COG0579	oxidoreductase
GSR16_RS20575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSR16_RS20580	COG3135	benzoate transporter
GSR16_RS20600	COG0006	proline dipeptidase activity
GSR16_RS20610	COG1522	sequence-specific DNA binding
GSR16_RS20615	COG0697	spore germination
GSR16_RS20645	COG3842	ATPase activity
GSR16_RS20650	COG1176	ABC-type spermidine putrescine transport system, permease component I
GSR16_RS20655	COG1177	transmembrane transport
GSR16_RS20660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GSR16_RS20680	COG1279	arginine transmembrane transporter activity
GSR16_RS20685	COG0069	glutamate synthase activity
GSR16_RS20700	COG2205	protein histidine kinase activity
GSR16_RS20705	COG0745	RESPONSE REGULATOR receiver
GSR16_RS20735	COG5002	protein histidine kinase activity
GSR16_RS20735	COG0784	Response regulator, receiver
GSR16_RS20740	COG3150	esterase
GSR16_RS20755	COG2199	diguanylate cyclase activity
GSR16_RS20755	COG2203	Gaf domain
GSR16_RS20760	COG2841	Protein conserved in bacteria
GSR16_RS20765	COG1132	(ABC) transporter
GSR16_RS20770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GSR16_RS20785	COG1451	nucleotide metabolic process
GSR16_RS20795	COG1522	sequence-specific DNA binding
GSR16_RS20805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GSR16_RS20815	COG4681	YaeQ
GSR16_RS20825	COG0513	Belongs to the DEAD box helicase family
GSR16_RS20840	COG3706	GGDEF domain
GSR16_RS20845	COG2207	Transcriptional regulator
GSR16_RS20850	COG1881	PFAM PEBP family protein
GSR16_RS20855	COG0745	RESPONSE REGULATOR receiver
GSR16_RS20855	COG3706	GGDEF domain
GSR16_RS20875	COG0783	Belongs to the Dps family
GSR16_RS20885	COG0840	transmembrane signaling receptor activity
GSR16_RS20890	COG3128	pkhd-type hydroxylase
GSR16_RS20895	COG4774	siderophore transport
GSR16_RS20915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GSR16_RS20920	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GSR16_RS20975	COG4968	Prepilin-type N-terminal cleavage methylation domain
GSR16_RS20980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process