locus-tag	class	description
DKK66_RS00010	COG0037	tRNA processing
DKK66_RS00015	COG0825	malonyl-CoA metabolic process
DKK66_RS00040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DKK66_RS00050	COG0312	modulator of DNA gyrase
DKK66_RS00055	COG3028	Belongs to the UPF0307 family
DKK66_RS00060	COG0521	Mo-molybdopterin cofactor biosynthetic process
DKK66_RS00065	COG0429	hydrolase of the alpha beta-hydrolase fold
DKK66_RS00070	COG0134	indole-3-glycerol-phosphate synthase activity
DKK66_RS00075	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKK66_RS00085	COG0183	Belongs to the thiolase family
DKK66_RS00090	COG1024	Enoyl-CoA hydratase
DKK66_RS00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKK66_RS00105	COG1960	acyl-CoA dehydrogenase activity
DKK66_RS00125	COG1286	toxin biosynthetic process
DKK66_RS00130	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DKK66_RS00135	COG0285	dihydrofolate synthase activity
DKK66_RS00150	COG0488	(ABC) transporter
DKK66_RS00155	COG0791	NLP P60 protein
DKK66_RS00190	COG0542	response to heat
DKK66_RS00205	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DKK66_RS00210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS00210	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DKK66_RS00220	COG0730	response to heat
DKK66_RS00235	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DKK66_RS00240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DKK66_RS00245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DKK66_RS00250	COG2205	protein histidine kinase activity
DKK66_RS00255	COG0745	RESPONSE REGULATOR receiver
DKK66_RS00265	COG1181	Belongs to the D-alanine--D-alanine ligase family
DKK66_RS00280	COG2356	endonuclease I
DKK66_RS00285	COG1609	Transcriptional regulator
DKK66_RS00295	COG2271	Major facilitator Superfamily
DKK66_RS00305	COG0183	Belongs to the thiolase family
DKK66_RS00320	COG1349	DNA-binding transcription factor activity
DKK66_RS00325	COG0583	DNA-binding transcription factor activity
DKK66_RS00345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DKK66_RS00350	COG0830	nickel cation binding
DKK66_RS00360	COG0804	urea catabolic process
DKK66_RS00365	COG0832	Belongs to the urease beta subunit family
DKK66_RS00370	COG0831	urea catabolic process
DKK66_RS00395	COG0559	Belongs to the binding-protein-dependent transport system permease family
DKK66_RS00415	COG0789	Transcriptional regulator
DKK66_RS00420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKK66_RS00430	COG2198	Histidine kinase
DKK66_RS00430	COG0784	Response regulator, receiver
DKK66_RS00430	COG5002	protein histidine kinase activity
DKK66_RS00445	COG2814	Major facilitator Superfamily
DKK66_RS00450	COG2134	cdp-diacylglycerol pyrophosphatase
DKK66_RS00470	COG4948	Mandelate Racemase Muconate Lactonizing
DKK66_RS00475	COG2223	nitrite transmembrane transporter activity
DKK66_RS00480	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS00485	COG0038	chloride channel
DKK66_RS00495	COG0501	Belongs to the peptidase M48B family
DKK66_RS00500	COG0583	DNA-binding transcription factor activity
DKK66_RS00515	COG0686	Belongs to the AlaDH PNT family
DKK66_RS00530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKK66_RS00535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKK66_RS00540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKK66_RS00545	COG0006	proline dipeptidase activity
DKK66_RS00550	COG0217	transcriptional regulatory protein
DKK66_RS00555	COG1684	flagellar biosynthetic protein fliR
DKK66_RS00560	COG1987	bacterial-type flagellum assembly
DKK66_RS00580	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DKK66_RS00610	COG3842	ATPase activity
DKK66_RS00620	COG1157	protein secretion by the type III secretion system
DKK66_RS00635	COG1766	The M ring may be actively involved in energy transduction
DKK66_RS00640	COG1677	Flagellar hook-basal body complex protein FliE
DKK66_RS00650	COG2201	protein-glutamate methylesterase activity
DKK66_RS00655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKK66_RS00660	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DKK66_RS00675	COG0840	transmembrane signaling receptor activity
DKK66_RS00690	COG0583	DNA-binding transcription factor activity
DKK66_RS00700	COG0556	nucleotide-excision repair
DKK66_RS00745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKK66_RS00755	COG0531	amino acid
DKK66_RS00760	COG4303	Ethanolamine ammonia lyase large subunit
DKK66_RS00765	COG4302	ethanolamine ammonia-lyase activity
DKK66_RS00780	COG0784	Response regulator, receiver
DKK66_RS00780	COG0835	chemotaxis
DKK66_RS00785	COG0784	Response regulator, receiver
DKK66_RS00785	COG0835	chemotaxis
DKK66_RS00790	COG0745	RESPONSE REGULATOR receiver
DKK66_RS00795	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DKK66_RS00805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS00815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKK66_RS00820	COG3938	Belongs to the proline racemase family
DKK66_RS00860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DKK66_RS00895	COG2188	Transcriptional regulator
DKK66_RS00900	COG1840	ABC-type Fe3 transport system, periplasmic component
DKK66_RS00910	COG3842	ATPase activity
DKK66_RS00915	COG1177	transmembrane transport
DKK66_RS00930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS00935	COG0583	DNA-binding transcription factor activity
DKK66_RS00940	COG0473	3-isopropylmalate dehydrogenase activity
DKK66_RS00960	COG0640	Transcriptional regulator
DKK66_RS00965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKK66_RS01005	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKK66_RS01030	COG1538	Outer membrane efflux protein
DKK66_RS01040	COG2902	Dehydrogenase
DKK66_RS01055	COG4215	(ABC) transporter
DKK66_RS01075	COG4191	Histidine kinase
DKK66_RS01105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DKK66_RS01130	COG0281	malic enzyme
DKK66_RS01130	COG0280	phosphate acetyltransferase
DKK66_RS01140	COG2990	Protein conserved in bacteria
DKK66_RS01145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKK66_RS01155	COG4178	(ABC) transporter
DKK66_RS01165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKK66_RS01165	COG1522	sequence-specific DNA binding
DKK66_RS01170	COG2313	pseudouridylate synthase activity
DKK66_RS01175	COG1418	mRNA catabolic process
DKK66_RS01190	COG2011	ABC-type metal ion transport system permease component
DKK66_RS01195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKK66_RS01215	COG0671	phosphoesterase, PA-phosphatase related
DKK66_RS01220	COG2059	Chromate
DKK66_RS01230	COG4566	intracellular signal transduction
DKK66_RS01235	COG3264	Mechanosensitive ion channel
DKK66_RS01235	COG1511	domain protein
DKK66_RS01240	COG1136	(ABC) transporter
DKK66_RS01255	COG0791	NLP P60 protein
DKK66_RS01280	COG1595	DNA-templated transcription, initiation
DKK66_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS01300	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DKK66_RS01310	COG1562	ergosterol biosynthetic process
DKK66_RS01345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DKK66_RS01365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DKK66_RS01370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DKK66_RS01375	COG1376	ErfK ybiS ycfS ynhG family protein
DKK66_RS01380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DKK66_RS01425	COG4735	regulation of single-species biofilm formation
DKK66_RS01465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DKK66_RS01510	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS01515	COG1177	transmembrane transport
DKK66_RS01520	COG1176	ABC-type spermidine putrescine transport system, permease component I
DKK66_RS01525	COG3842	ATPase activity
DKK66_RS01530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DKK66_RS01535	COG0583	DNA-binding transcription factor activity
DKK66_RS01545	COG1530	ribonuclease E activity
DKK66_RS01570	COG1360	Flagellar Motor Protein
DKK66_RS01580	COG0167	dihydroorotate dehydrogenase activity
DKK66_RS01590	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DKK66_RS01595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DKK66_RS01605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DKK66_RS01610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DKK66_RS01615	COG4139	cobalamin transport
DKK66_RS01620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DKK66_RS01625	COG2719	SpoVR family
DKK66_RS01630	COG2718	Belongs to the UPF0229 family
DKK66_RS01635	COG2766	serine protein kinase
DKK66_RS01655	COG1960	acyl-CoA dehydrogenase activity
DKK66_RS01660	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS01680	COG3618	amidohydrolase
DKK66_RS01685	COG3254	rhamnose metabolic process
DKK66_RS01690	COG4948	Mandelate Racemase Muconate Lactonizing
DKK66_RS01700	COG3318	Belongs to the UPF0149 family
DKK66_RS01700	COG3012	SEC-C Motif Domain Protein
DKK66_RS01705	COG0318	PFAM AMP-dependent synthetase and ligase
DKK66_RS01715	COG1960	acyl-CoA dehydrogenase activity
DKK66_RS01720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DKK66_RS01745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKK66_RS01760	COG0254	rRNA binding
DKK66_RS01765	COG0215	cysteine-tRNA ligase activity
DKK66_RS01770	COG0205	6-phosphofructokinase activity
DKK66_RS01775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKK66_RS01785	COG1032	radical SAM domain protein
DKK66_RS01790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DKK66_RS01795	COG0659	secondary active sulfate transmembrane transporter activity
DKK66_RS01815	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKK66_RS01820	COG0840	transmembrane signaling receptor activity
DKK66_RS01825	COG1620	l-lactate permease
DKK66_RS01830	COG0246	Mannitol dehydrogenase
DKK66_RS01835	COG0477	Major facilitator Superfamily
DKK66_RS01840	COG1063	alcohol dehydrogenase
DKK66_RS01845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DKK66_RS01855	COG0583	DNA-binding transcription factor activity
DKK66_RS01860	COG3162	membrane
DKK66_RS01870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKK66_RS01875	COG3781	membrane
DKK66_RS01895	COG2878	Part of a membrane complex involved in electron transport
DKK66_RS01900	COG4656	Part of a membrane complex involved in electron transport
DKK66_RS01905	COG4658	electron transport chain
DKK66_RS01910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DKK66_RS01915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKK66_RS01920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DKK66_RS01930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DKK66_RS01935	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DKK66_RS01940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DKK66_RS01955	COG0617	tRNA 3'-terminal CCA addition
DKK66_RS01970	COG0534	Mate efflux family protein
DKK66_RS01975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DKK66_RS02015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DKK66_RS02025	COG4172	Belongs to the ABC transporter superfamily
DKK66_RS02030	COG4239	(ABC) transporter, permease
DKK66_RS02035	COG4174	ABC transporter (Permease)
DKK66_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS02065	COG1846	Transcriptional regulator
DKK66_RS02075	COG1113	amino acid transport
DKK66_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS02095	COG2207	Transcriptional regulator
DKK66_RS02115	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS02120	COG3384	dioxygenase
DKK66_RS02130	COG2814	Major facilitator Superfamily
DKK66_RS02140	COG3971	2-oxopent-4-enoate hydratase activity
DKK66_RS02160	COG1960	acyl-CoA dehydrogenase activity
DKK66_RS02165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKK66_RS02185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DKK66_RS02200	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DKK66_RS02210	COG2204	response regulator
DKK66_RS02220	COG2205	protein histidine kinase activity
DKK66_RS02250	COG0557	exoribonuclease II activity
DKK66_RS02270	COG0477	Major facilitator Superfamily
DKK66_RS02280	COG1858	cytochrome C peroxidase
DKK66_RS02290	COG0673	inositol 2-dehydrogenase activity
DKK66_RS02295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DKK66_RS02300	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DKK66_RS02305	COG0330	HflC and HflK could
DKK66_RS02310	COG0330	HflC and HflK could
DKK66_RS02315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DKK66_RS02320	COG1923	regulation of RNA biosynthetic process
DKK66_RS02325	COG1160	GTP binding
DKK66_RS02340	COG0124	histidyl-tRNA synthetase
DKK66_RS02345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DKK66_RS02350	COG1426	Protein conserved in bacteria
DKK66_RS02360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DKK66_RS02365	COG0105	UTP biosynthetic process
DKK66_RS02380	COG3718	enzyme involved in inositol metabolism
DKK66_RS02405	COG1172	Belongs to the binding-protein-dependent transport system permease family
DKK66_RS02410	COG1129	ABC transporter
DKK66_RS02425	COG3962	Belongs to the TPP enzyme family
DKK66_RS02430	COG1609	Transcriptional regulator
DKK66_RS02435	COG1082	Xylose isomerase domain protein TIM barrel
DKK66_RS02445	COG0673	inositol 2-dehydrogenase activity
DKK66_RS02465	COG0673	inositol 2-dehydrogenase activity
DKK66_RS02470	COG0673	inositol 2-dehydrogenase activity
DKK66_RS02490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKK66_RS02495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKK66_RS02520	COG2974	May be involved in recombination
DKK66_RS02530	COG3384	dioxygenase
DKK66_RS02535	COG0167	dihydroorotate dehydrogenase activity
DKK66_RS02540	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DKK66_RS02550	COG0717	Belongs to the dCTP deaminase family
DKK66_RS02560	COG3012	SEC-C Motif Domain Protein
DKK66_RS02575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKK66_RS02580	COG1929	Belongs to the glycerate kinase type-1 family
DKK66_RS02595	COG1448	Aminotransferase
DKK66_RS02620	COG3188	usher protein
DKK66_RS02655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DKK66_RS02660	COG0322	excinuclease ABC activity
DKK66_RS02680	COG0596	Alpha beta hydrolase
DKK66_RS02690	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DKK66_RS02700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKK66_RS02700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DKK66_RS02705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DKK66_RS02710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DKK66_RS02720	COG0625	glutathione transferase activity
DKK66_RS02725	COG0129	dihydroxy-acid dehydratase activity
DKK66_RS02730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DKK66_RS02735	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DKK66_RS02745	COG3639	organic phosphonate transmembrane transporter activity
DKK66_RS02750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKK66_RS02755	COG0765	amino acid transport
DKK66_RS02760	COG0765	amino acid transport
DKK66_RS02780	COG2217	Heavy metal translocating P-type atpase
DKK66_RS02785	COG0598	Magnesium transport protein CorA
DKK66_RS02790	COG0248	Ppx GppA phosphatase
DKK66_RS02795	COG0704	Plays a role in the regulation of phosphate uptake
DKK66_RS02800	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DKK66_RS02805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DKK66_RS02810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DKK66_RS02820	COG0328	RNA-DNA hybrid ribonuclease activity
DKK66_RS02825	COG2226	methyltransferase
DKK66_RS02830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKK66_RS02835	COG1388	LysM domain
DKK66_RS02835	COG0741	lytic transglycosylase activity
DKK66_RS02840	COG1490	D-aminoacyl-tRNA deacylase activity
DKK66_RS02845	COG0384	phenazine biosynthesis protein PhzF
DKK66_RS02850	COG3022	response to hydroperoxide
DKK66_RS02855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DKK66_RS02875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKK66_RS02875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKK66_RS02885	COG0489	protein tyrosine kinase activity
DKK66_RS02900	COG2732	(Barnase) inhibitor
DKK66_RS02905	COG0436	Aminotransferase
DKK66_RS02920	COG2169	Transcriptional regulator
DKK66_RS02920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DKK66_RS02925	COG3145	DNA-N1-methyladenine dioxygenase activity
DKK66_RS02930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKK66_RS02935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKK66_RS02945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DKK66_RS02960	COG0308	aminopeptidase N
DKK66_RS02970	COG3278	Belongs to the heme-copper respiratory oxidase family
DKK66_RS02985	COG2010	Cytochrome c
DKK66_RS02990	COG0348	domain, Protein
DKK66_RS03005	COG3033	Beta-eliminating lyase
DKK66_RS03010	COG3104	oligopeptide transport
DKK66_RS03020	COG0463	Glycosyl transferase, family 2
DKK66_RS03035	COG0564	pseudouridine synthase activity
DKK66_RS03040	COG1607	acyl-coa hydrolase
DKK66_RS03055	COG1380	Effector of murein hydrolase LrgA
DKK66_RS03060	COG0583	DNA-binding transcription factor activity
DKK66_RS03080	COG0045	succinate-CoA ligase (ADP-forming) activity
DKK66_RS03085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKK66_RS03095	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKK66_RS03100	COG0567	Dehydrogenase, E1 component
DKK66_RS03110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DKK66_RS03115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DKK66_RS03120	COG1053	succinate dehydrogenase
DKK66_RS03130	COG2009	succinate dehydrogenase
DKK66_RS03140	COG0039	L-malate dehydrogenase activity
DKK66_RS03150	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DKK66_RS03160	COG0402	S-adenosylhomocysteine deaminase activity
DKK66_RS03165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DKK66_RS03180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DKK66_RS03185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DKK66_RS03190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DKK66_RS03205	COG1191	sigma factor activity
DKK66_RS03210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DKK66_RS03215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DKK66_RS03215	COG1199	ATP-dependent helicase activity
DKK66_RS03240	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DKK66_RS03245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DKK66_RS03255	COG0583	DNA-binding transcription factor activity
DKK66_RS03270	COG0850	regulation of cytokinetic process
DKK66_RS03280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DKK66_RS03285	COG0583	DNA-binding transcription factor activity
DKK66_RS03290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKK66_RS03310	COG1187	pseudouridine synthase activity
DKK66_RS03315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DKK66_RS03325	COG0583	DNA-binding transcription factor activity
DKK66_RS03335	COG0180	Tryptophanyl-tRNA synthetase
DKK66_RS03340	COG1994	Peptidase M50
DKK66_RS03345	COG0009	L-threonylcarbamoyladenylate synthase
DKK66_RS03350	COG0613	PHP domain protein
DKK66_RS03375	COG0252	asparaginase activity
DKK66_RS03390	COG2188	Transcriptional regulator
DKK66_RS03410	COG3842	ATPase activity
DKK66_RS03425	COG0861	Integral membrane protein TerC family
DKK66_RS03430	COG1914	H( )-stimulated, divalent metal cation uptake system
DKK66_RS03435	COG0330	HflC and HflK could
DKK66_RS03440	COG0330	HflC and HflK could
DKK66_RS03455	COG0583	DNA-binding transcription factor activity
DKK66_RS03490	COG0154	amidase activity
DKK66_RS03500	COG2957	Belongs to the agmatine deiminase family
DKK66_RS03525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DKK66_RS03535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DKK66_RS03540	COG1137	ATPase activity
DKK66_RS03545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DKK66_RS03550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DKK66_RS03560	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DKK66_RS03565	COG1660	Displays ATPase and GTPase activities
DKK66_RS03575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DKK66_RS03575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DKK66_RS03585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKK66_RS03585	COG4191	Histidine kinase
DKK66_RS03590	COG3437	response regulator, receiver
DKK66_RS03590	COG0784	Response regulator, receiver
DKK66_RS03595	COG1272	protein, Hemolysin III
DKK66_RS03600	COG0563	adenylate kinase activity
DKK66_RS03605	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DKK66_RS03610	COG2835	tetraacyldisaccharide 4'-kinase activity
DKK66_RS03615	COG1663	tetraacyldisaccharide 4'-kinase activity
DKK66_RS03620	COG0848	biopolymer transport protein
DKK66_RS03625	COG0811	peptide transport
DKK66_RS03630	COG1570	exodeoxyribonuclease VII activity
DKK66_RS03645	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DKK66_RS03650	COG4942	peptidase
DKK66_RS03655	COG0793	Belongs to the peptidase S41A family
DKK66_RS03660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DKK66_RS03660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DKK66_RS03665	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DKK66_RS03680	COG0488	(ABC) transporter
DKK66_RS03690	COG4942	peptidase
DKK66_RS03695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DKK66_RS03725	COG0527	aspartate kinase activity
DKK66_RS03730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DKK66_RS03735	COG3383	formate dehydrogenase (NAD+) activity
DKK66_RS03735	COG0243	molybdopterin cofactor binding
DKK66_RS03740	COG3383	formate dehydrogenase (NAD+) activity
DKK66_RS03740	COG0243	molybdopterin cofactor binding
DKK66_RS03745	COG0437	4 iron, 4 sulfur cluster binding
DKK66_RS03750	COG2864	formate dehydrogenase
DKK66_RS03760	COG0745	RESPONSE REGULATOR receiver
DKK66_RS03770	COG2198	Histidine kinase
DKK66_RS03770	COG0643	Histidine kinase
DKK66_RS03790	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DKK66_RS03795	COG2201	protein-glutamate methylesterase activity
DKK66_RS03800	COG3706	GGDEF domain
DKK66_RS03800	COG5001	Diguanylate cyclase
DKK66_RS03800	COG2203	Gaf domain
DKK66_RS03800	COG4251	negative regulation of phosphorylation
DKK66_RS03805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKK66_RS03815	COG1921	L-seryl-tRNASec selenium transferase activity
DKK66_RS03830	COG3276	selenocysteine insertion sequence binding
DKK66_RS03850	COG0247	lactate metabolic process
DKK66_RS03855	COG1139	Iron-sulfur cluster binding protein
DKK66_RS03865	COG0513	Belongs to the DEAD box helicase family
DKK66_RS03870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DKK66_RS03905	COG0436	Aminotransferase
DKK66_RS03915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKK66_RS03925	COG2610	gluconate transmembrane transporter activity
DKK66_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS03945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DKK66_RS03960	COG2226	methyltransferase
DKK66_RS03970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DKK66_RS03975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DKK66_RS03980	COG0511	ligase activity, forming carbon-carbon bonds
DKK66_RS03985	COG0439	Biotin carboxylase
DKK66_RS03990	COG2264	protein methyltransferase activity
DKK66_RS04010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DKK66_RS04020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DKK66_RS04035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DKK66_RS04040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DKK66_RS04055	COG2059	Chromate
DKK66_RS04060	COG0583	DNA-binding transcription factor activity
DKK66_RS04080	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DKK66_RS04100	COG0583	DNA-binding transcription factor activity
DKK66_RS04105	COG0840	transmembrane signaling receptor activity
DKK66_RS04125	COG1301	dicarboxylic acid transport
DKK66_RS04145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DKK66_RS04150	COG2022	thiamine diphosphate biosynthetic process
DKK66_RS04160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKK66_RS04165	COG1758	RNA polymerase activity
DKK66_RS04170	COG0194	GDP metabolic process
DKK66_RS04175	COG2252	PERMEase
DKK66_RS04180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DKK66_RS04190	COG1695	Transcriptional regulator
DKK66_RS04205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DKK66_RS04210	COG2235	arginine
DKK66_RS04225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKK66_RS04225	COG0543	2 iron, 2 sulfur cluster binding
DKK66_RS04235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DKK66_RS04240	COG0386	Belongs to the glutathione peroxidase family
DKK66_RS04250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DKK66_RS04265	COG0586	Pfam SNARE associated Golgi protein
DKK66_RS04270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKK66_RS04275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DKK66_RS04285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKK66_RS04290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DKK66_RS04295	COG1534	Rna-binding protein
DKK66_RS04325	COG1960	acyl-CoA dehydrogenase activity
DKK66_RS04340	COG2030	dehydratase
DKK66_RS04355	COG0802	atpase or kinase
DKK66_RS04360	COG0860	N-Acetylmuramoyl-L-alanine amidase
DKK66_RS04365	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DKK66_RS04370	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DKK66_RS04375	COG0237	dephospho-CoA kinase activity
DKK66_RS04380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DKK66_RS04400	COG0415	Belongs to the DNA photolyase family
DKK66_RS04405	COG1596	polysaccharide export
DKK66_RS04405	COG1555	photosystem II stabilization
DKK66_RS04410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DKK66_RS04415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DKK66_RS04435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DKK66_RS04455	COG0347	Belongs to the P(II) protein family
DKK66_RS04460	COG0004	ammonium transporteR
DKK66_RS04465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DKK66_RS04475	COG1560	Kdo2-lipid A biosynthetic process
DKK66_RS04485	COG1007	ATP synthesis coupled electron transport
DKK66_RS04500	COG0713	ATP synthesis coupled electron transport
DKK66_RS04510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKK66_RS04515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DKK66_RS04520	COG1034	ATP synthesis coupled electron transport
DKK66_RS04530	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DKK66_RS04535	COG0649	NAD binding
DKK66_RS04540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKK66_RS04545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKK66_RS04550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DKK66_RS04560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DKK66_RS04565	COG0149	triose-phosphate isomerase activity
DKK66_RS04585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DKK66_RS04590	COG0306	phosphate transporter
DKK66_RS04595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DKK66_RS04620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DKK66_RS04625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DKK66_RS04630	COG0109	protoheme IX farnesyltransferase activity
DKK66_RS04650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DKK66_RS04655	COG0840	transmembrane signaling receptor activity
DKK66_RS04660	COG0745	RESPONSE REGULATOR receiver
DKK66_RS04665	COG2205	protein histidine kinase activity
DKK66_RS04675	COG3591	Belongs to the peptidase S1B family
DKK66_RS04680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DKK66_RS04685	COG0631	protein serine/threonine phosphatase activity
DKK66_RS04690	COG1357	PFAM Pentapeptide repeats (8 copies)
DKK66_RS04690	COG0515	serine threonine protein kinase
DKK66_RS04695	COG1561	YicC-like family, N-terminal region
DKK66_RS04715	COG3813	Protein conserved in bacteria
DKK66_RS04720	COG2084	Dehydrogenase
DKK66_RS04725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DKK66_RS04760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DKK66_RS04765	COG1216	Glycosyl transferase, family 2
DKK66_RS04765	COG0438	transferase activity, transferring glycosyl groups
DKK66_RS04770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DKK66_RS04790	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS04795	COG0318	PFAM AMP-dependent synthetase and ligase
DKK66_RS04815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DKK66_RS04820	COG1678	Uncharacterized ACR, COG1678
DKK66_RS04830	COG2223	nitrite transmembrane transporter activity
DKK66_RS04840	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DKK66_RS04845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DKK66_RS04855	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DKK66_RS04865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKK66_RS04870	COG1846	Transcriptional regulator
DKK66_RS04875	COG3038	cytochrome b561
DKK66_RS04880	COG2353	YceI-like domain
DKK66_RS04900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DKK66_RS04935	COG1414	Transcriptional regulator
DKK66_RS04945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DKK66_RS04960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKK66_RS04965	COG1538	Outer membrane efflux protein
DKK66_RS04970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKK66_RS05035	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DKK66_RS05040	COG0514	ATP-dependent DNA helicase (RecQ)
DKK66_RS05050	COG1192	Involved in chromosome partitioning
DKK66_RS05055	COG2205	protein histidine kinase activity
DKK66_RS05070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DKK66_RS05085	COG2900	Belongs to the SlyX family
DKK66_RS05105	COG2171	N-acyltransferase activity
DKK66_RS05110	COG1127	ABC transporter
DKK66_RS05115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DKK66_RS05120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DKK66_RS05135	COG2853	Lipoprotein
DKK66_RS05140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DKK66_RS05150	COG0842	Transport permease protein
DKK66_RS05155	COG1131	(ABC) transporter
DKK66_RS05195	COG3047	cAMP biosynthetic process
DKK66_RS05200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DKK66_RS05205	COG3171	Protein conserved in bacteria
DKK66_RS05225	COG1027	Aspartate ammonia-lyase
DKK66_RS05230	COG0406	alpha-ribazole phosphatase activity
DKK66_RS05235	COG0583	DNA-binding transcription factor activity
DKK66_RS05250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKK66_RS05255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DKK66_RS05280	COG0297	glycogen (starch) synthase activity
DKK66_RS05325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DKK66_RS05330	COG0037	tRNA processing
DKK66_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS05360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DKK66_RS05365	COG1187	pseudouridine synthase activity
DKK66_RS05385	COG1879	ABC-type sugar transport system periplasmic component
DKK66_RS05390	COG1172	Belongs to the binding-protein-dependent transport system permease family
DKK66_RS05395	COG1129	ABC transporter
DKK66_RS05400	COG1869	D-ribose catabolic process
DKK66_RS05405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKK66_RS05415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DKK66_RS05430	COG1702	phosphate starvation-inducible protein PhoH
DKK66_RS05435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DKK66_RS05440	COG4535	Mg2 and Co2 transporter CorC
DKK66_RS05445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DKK66_RS05450	COG0840	transmembrane signaling receptor activity
DKK66_RS05455	COG0633	Ferredoxin
DKK66_RS05455	COG3217	Mosc domain protein beta barrel domain protein
DKK66_RS05460	COG0203	ribosomal protein L17
DKK66_RS05465	COG0202	RNA polymerase activity
DKK66_RS05470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DKK66_RS05475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DKK66_RS05480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DKK66_RS05485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DKK66_RS05490	COG0201	protein transport
DKK66_RS05495	COG0200	Binds to the 23S rRNA
DKK66_RS05500	COG1841	ribosomal large subunit assembly
DKK66_RS05505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DKK66_RS05510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DKK66_RS05515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DKK66_RS05520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DKK66_RS05525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DKK66_RS05530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DKK66_RS05535	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DKK66_RS05540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DKK66_RS05545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DKK66_RS05550	COG0255	Belongs to the universal ribosomal protein uL29 family
DKK66_RS05555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DKK66_RS05560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DKK66_RS05565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DKK66_RS05570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DKK66_RS05575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DKK66_RS05580	COG0089	rRNA binding
DKK66_RS05585	COG0088	Forms part of the polypeptide exit tunnel
DKK66_RS05590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DKK66_RS05595	COG0051	transcription antitermination factor activity, RNA binding
DKK66_RS05600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKK66_RS05605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DKK66_RS05610	COG0049	tRNA binding
DKK66_RS05615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DKK66_RS05620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DKK66_RS05625	COG0085	RNA polymerase activity
DKK66_RS05630	COG0222	ribosome binding
DKK66_RS05635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DKK66_RS05645	COG0081	regulation of translation
DKK66_RS05650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DKK66_RS05670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DKK66_RS05690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DKK66_RS05695	COG0742	ribosomal rna small subunit methyltransferase
DKK66_RS05705	COG0612	Peptidase, M16
DKK66_RS05715	COG2884	Cell division ATP-binding protein ftsE
DKK66_RS05725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DKK66_RS05730	COG3307	-O-antigen
DKK66_RS05745	COG4969	Belongs to the N-Me-Phe pilin family
DKK66_RS05760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DKK66_RS05775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKK66_RS05775	COG0519	Catalyzes the synthesis of GMP from XMP
DKK66_RS05780	COG2255	four-way junction helicase activity
DKK66_RS05785	COG0632	four-way junction helicase activity
DKK66_RS05795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DKK66_RS05800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DKK66_RS05810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DKK66_RS05815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKK66_RS05820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DKK66_RS05830	COG0625	glutathione transferase activity
DKK66_RS05840	COG1253	flavin adenine dinucleotide binding
DKK66_RS05865	COG0708	Exodeoxyribonuclease III
DKK66_RS05870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DKK66_RS05905	COG1324	tolerance protein
DKK66_RS05915	COG1872	DUF167
DKK66_RS05920	COG0783	Belongs to the Dps family
DKK66_RS05935	COG0824	Thioesterase
DKK66_RS05940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKK66_RS05945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DKK66_RS05950	COG2204	response regulator
DKK66_RS05955	COG5000	phosphorelay sensor kinase activity
DKK66_RS05970	COG0501	Belongs to the peptidase M48B family
DKK66_RS05975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DKK66_RS05980	COG0242	peptide deformylase activity
DKK66_RS05990	COG0758	DNA mediated transformation
DKK66_RS05995	COG2922	Belongs to the Smg family
DKK66_RS06025	COG0189	ligase activity
DKK66_RS06040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKK66_RS06045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKK66_RS06050	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKK66_RS06050	COG1902	pentaerythritol trinitrate reductase activity
DKK66_RS06060	COG2267	carboxylic ester hydrolase activity
DKK66_RS06065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKK66_RS06070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DKK66_RS06075	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DKK66_RS06090	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DKK66_RS06095	COG2885	chlorophyll binding
DKK66_RS06100	COG0823	Involved in the tonB-independent uptake of proteins
DKK66_RS06140	COG0210	DNA helicase
DKK66_RS06155	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DKK66_RS06175	COG1045	serine acetyltransferase
DKK66_RS06180	COG1530	ribonuclease E activity
DKK66_RS06185	COG0424	maF-like protein
DKK66_RS06190	COG0653	protein targeting
DKK66_RS06200	COG1116	anion transmembrane transporter activity
DKK66_RS06215	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DKK66_RS06220	COG4208	sulfate ABC transporter
DKK66_RS06240	COG0840	transmembrane signaling receptor activity
DKK66_RS06245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DKK66_RS06265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DKK66_RS06295	COG0174	glutamine synthetase
DKK66_RS06300	COG0405	Gamma-glutamyltransferase
DKK66_RS06310	COG0589	response to stress
DKK66_RS06320	COG3132	Protein of unknown function, DUF480
DKK66_RS06340	COG1505	serine-type exopeptidase activity
DKK66_RS06365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DKK66_RS06370	COG0501	Belongs to the peptidase M48B family
DKK66_RS06375	COG4608	Belongs to the ABC transporter superfamily
DKK66_RS06385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKK66_RS06390	COG0601	transmembrane transport
DKK66_RS06395	COG4166	transmembrane transport
DKK66_RS06400	COG0418	dihydroorotase activity
DKK66_RS06430	COG0315	cyclic pyranopterin monophosphate synthase activity
DKK66_RS06440	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DKK66_RS06455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DKK66_RS06460	COG1181	Belongs to the D-alanine--D-alanine ligase family
DKK66_RS06465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKK66_RS06470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DKK66_RS06475	COG0772	Belongs to the SEDS family
DKK66_RS06480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DKK66_RS06485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DKK66_RS06490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DKK66_RS06495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DKK66_RS06505	COG3116	cell division
DKK66_RS06510	COG0275	rRNA processing
DKK66_RS06515	COG2001	Belongs to the MraZ family
DKK66_RS06520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKK66_RS06525	COG0154	amidase activity
DKK66_RS06530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DKK66_RS06535	COG1077	Cell shape determining protein MreB Mrl
DKK66_RS06540	COG1792	Involved in formation and maintenance of cell shape
DKK66_RS06545	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DKK66_RS06550	COG0768	penicillin binding
DKK66_RS06555	COG0772	Belongs to the SEDS family
DKK66_RS06570	COG3791	Glutathione-dependent formaldehyde-activating
DKK66_RS06585	COG2847	Copper chaperone PCu(A)C
DKK66_RS06595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DKK66_RS06600	COG0625	glutathione transferase activity
DKK66_RS06605	COG1752	Esterase of the alpha-beta hydrolase superfamily
DKK66_RS06610	COG2226	methyltransferase
DKK66_RS06615	COG2267	carboxylic ester hydrolase activity
DKK66_RS06620	COG5001	Diguanylate cyclase
DKK66_RS06620	COG3300	MHYT domain
DKK66_RS06625	COG0156	8-amino-7-oxononanoate synthase activity
DKK66_RS06630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DKK66_RS06635	COG1040	competence protein
DKK66_RS06640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DKK66_RS06650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DKK66_RS06660	COG1333	cytochrome c biogenesis protein
DKK66_RS06665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DKK66_RS06670	COG1253	flavin adenine dinucleotide binding
DKK66_RS06675	COG2827	Endonuclease containing a URI domain
DKK66_RS06685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKK66_RS06700	COG0166	Belongs to the GPI family
DKK66_RS06710	COG0837	glucose binding
DKK66_RS06720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DKK66_RS06725	COG0129	dihydroxy-acid dehydratase activity
DKK66_RS06730	COG0800	Aldolase
DKK66_RS06750	COG1175	transmembrane transport
DKK66_RS06755	COG0395	ABC-type sugar transport system, permease component
DKK66_RS06760	COG3842	ATPase activity
DKK66_RS06765	COG4989	oxidoreductase activity
DKK66_RS06775	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DKK66_RS06790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DKK66_RS06795	COG2200	EAL domain
DKK66_RS06800	COG0165	Argininosuccinate lyase
DKK66_RS06815	COG3275	phosphorelay sensor kinase activity
DKK66_RS06830	COG1902	pentaerythritol trinitrate reductase activity
DKK66_RS06830	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKK66_RS06850	COG0028	Belongs to the TPP enzyme family
DKK66_RS06855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DKK66_RS06860	COG0181	hydroxymethylbilane synthase activity
DKK66_RS06870	COG2959	enzyme of heme biosynthesis
DKK66_RS06890	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DKK66_RS06905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DKK66_RS06910	COG0706	membrane insertase activity
DKK66_RS06915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DKK66_RS06920	COG0594	ribonuclease P activity
DKK66_RS06925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DKK66_RS06930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DKK66_RS06945	COG5002	protein histidine kinase activity
DKK66_RS06985	COG2197	response regulator
DKK66_RS07000	COG0438	transferase activity, transferring glycosyl groups
DKK66_RS07010	COG3177	Filamentation induced by cAMP protein fic
DKK66_RS07015	COG3177	Filamentation induced by cAMP protein fic
DKK66_RS07085	COG2066	Belongs to the glutaminase family
DKK66_RS07100	COG1858	cytochrome C peroxidase
DKK66_RS07120	COG4251	negative regulation of phosphorylation
DKK66_RS07120	COG2203	Gaf domain
DKK66_RS07120	COG5001	Diguanylate cyclase
DKK66_RS07120	COG3706	GGDEF domain
DKK66_RS07130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS07140	COG0583	DNA-binding transcription factor activity
DKK66_RS07150	COG1132	(ABC) transporter
DKK66_RS07185	COG1917	Cupin 2, conserved barrel domain protein
DKK66_RS07200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DKK66_RS07205	COG4569	acetaldehyde dehydrogenase (acetylating) activity
DKK66_RS07210	COG3971	2-oxopent-4-enoate hydratase activity
DKK66_RS07215	COG0583	DNA-binding transcription factor activity
DKK66_RS07230	COG0583	DNA-binding transcription factor activity
DKK66_RS07235	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DKK66_RS07265	COG0259	pyridoxamine-phosphate oxidase activity
DKK66_RS07270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DKK66_RS07275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DKK66_RS07280	COG0583	DNA-binding transcription factor activity
DKK66_RS07290	COG2201	protein-glutamate methylesterase activity
DKK66_RS07345	COG2153	protein acetylation
DKK66_RS07355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DKK66_RS07360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DKK66_RS07365	COG0126	phosphoglycerate kinase activity
DKK66_RS07370	COG1280	lysine exporter protein (LysE YggA)
DKK66_RS07385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DKK66_RS07390	COG0314	molybdopterin synthase activity
DKK66_RS07395	COG0746	molybdenum cofactor guanylyltransferase activity
DKK66_RS07400	COG0583	DNA-binding transcription factor activity
DKK66_RS07410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DKK66_RS07420	COG4654	Cytochrome c, class I
DKK66_RS07425	COG0762	integral membrane protein
DKK66_RS07455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DKK66_RS07460	COG1126	abc transporter atp-binding protein
DKK66_RS07465	COG0765	amino acid transport
DKK66_RS07470	COG0765	amino acid transport
DKK66_RS07475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKK66_RS07480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKK66_RS07485	COG1238	metal cluster binding
DKK66_RS07490	COG1965	Belongs to the frataxin family
DKK66_RS07495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DKK66_RS07510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DKK66_RS07515	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DKK66_RS07520	COG2954	triphosphatase activity
DKK66_RS07525	COG1981	membrane
DKK66_RS07530	COG4783	chaperone-mediated protein folding
DKK66_RS07535	COG1773	rubredoxin
DKK66_RS07540	COG0351	phosphomethylpyrimidine kinase
DKK66_RS07545	COG0352	thiamine-phosphate diphosphorylase activity
DKK66_RS07560	COG0842	Transport permease protein
DKK66_RS07565	COG0842	Transport permease protein
DKK66_RS07570	COG1131	(ABC) transporter
DKK66_RS07575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKK66_RS07585	COG1519	Transferase
DKK66_RS07590	COG0859	PFAM glycosyl transferase family 9
DKK66_RS07610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKK66_RS07610	COG4651	solute:proton antiporter activity
DKK66_RS07615	COG1253	flavin adenine dinucleotide binding
DKK66_RS07620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DKK66_RS07630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DKK66_RS07635	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DKK66_RS07650	COG3214	Protein conserved in bacteria
DKK66_RS07665	COG0826	peptidase U32
DKK66_RS07695	COG4628	conserved protein (DUF2132)
DKK66_RS07710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DKK66_RS07715	COG0668	transmembrane transport
DKK66_RS07735	COG0540	Belongs to the ATCase OTCase family
DKK66_RS07740	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DKK66_RS07745	COG1247	-acetyltransferase
DKK66_RS07810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DKK66_RS07820	COG0676	glucose-6-phosphate 1-epimerase activity
DKK66_RS07825	COG2188	Transcriptional regulator
DKK66_RS07830	COG1968	undecaprenyl-diphosphatase activity
DKK66_RS07835	COG1228	amidohydrolase
DKK66_RS07840	COG0010	Belongs to the arginase family
DKK66_RS07845	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DKK66_RS07850	COG2986	histidine ammonia-lyase
DKK66_RS07855	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DKK66_RS07890	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DKK66_RS07895	COG2267	carboxylic ester hydrolase activity
DKK66_RS07905	COG0469	pyruvate kinase activity
DKK66_RS07910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DKK66_RS07915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DKK66_RS07950	COG0579	oxidoreductase
DKK66_RS07955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKK66_RS07960	COG3135	benzoate transporter
DKK66_RS07975	COG2707	UPF0756 membrane protein
DKK66_RS07980	COG0006	proline dipeptidase activity
DKK66_RS07990	COG1522	sequence-specific DNA binding
DKK66_RS07995	COG0697	spore germination
DKK66_RS08025	COG3842	ATPase activity
DKK66_RS08030	COG1176	ABC-type spermidine putrescine transport system, permease component I
DKK66_RS08035	COG1177	transmembrane transport
DKK66_RS08050	COG0069	glutamate synthase activity
DKK66_RS08105	COG3150	esterase
DKK66_RS08115	COG0646	methionine synthase
DKK66_RS08115	COG1410	methionine synthase
DKK66_RS08120	COG2203	Gaf domain
DKK66_RS08120	COG2199	diguanylate cyclase activity
DKK66_RS08125	COG2841	Protein conserved in bacteria
DKK66_RS08130	COG1132	(ABC) transporter
DKK66_RS08135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DKK66_RS08140	COG2199	diguanylate cyclase activity
DKK66_RS08140	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DKK66_RS08150	COG0657	acetylesterase activity
DKK66_RS08155	COG1451	nucleotide metabolic process
DKK66_RS08165	COG1522	sequence-specific DNA binding
DKK66_RS08175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKK66_RS08195	COG0513	Belongs to the DEAD box helicase family
DKK66_RS08240	COG0783	Belongs to the Dps family
DKK66_RS08245	COG0840	transmembrane signaling receptor activity
DKK66_RS08250	COG0840	transmembrane signaling receptor activity
DKK66_RS08255	COG3128	pkhd-type hydroxylase
DKK66_RS08260	COG4774	siderophore transport
DKK66_RS08280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DKK66_RS08285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DKK66_RS08345	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DKK66_RS08355	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DKK66_RS08385	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DKK66_RS08395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DKK66_RS08410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKK66_RS08425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DKK66_RS08440	COG0495	leucyl-tRNA aminoacylation
DKK66_RS08450	COG1466	dna polymerase III delta subunit
DKK66_RS08460	COG1196	nuclear chromosome segregation
DKK66_RS08460	COG0739	heme binding
DKK66_RS08460	COG0741	lytic transglycosylase activity
DKK66_RS08465	COG3753	Protein conserved in bacteria
DKK66_RS08490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DKK66_RS08495	COG0799	negative regulation of ribosome biogenesis
DKK66_RS08500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DKK66_RS08505	COG0288	reversible hydration of carbon dioxide
DKK66_RS08525	COG0640	Transcriptional regulator
DKK66_RS08530	COG2391	methyltransferase activity
DKK66_RS08545	COG4783	chaperone-mediated protein folding
DKK66_RS08555	COG0508	dehydrogenase complex catalyzes the overall conversion of
DKK66_RS08560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DKK66_RS08575	COG1473	amidohydrolase
DKK66_RS08585	COG0477	Major facilitator Superfamily
DKK66_RS08610	COG0138	bifunctional purine biosynthesis protein purh
DKK66_RS08630	COG0009	L-threonylcarbamoyladenylate synthase
DKK66_RS08640	COG0697	spore germination
DKK66_RS08645	COG2188	Transcriptional regulator
DKK66_RS08650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DKK66_RS08655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DKK66_RS08660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DKK66_RS08660	COG2190	(PTS) system
DKK66_RS08660	COG1263	PTS System
DKK66_RS08665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DKK66_RS08670	COG1522	sequence-specific DNA binding
DKK66_RS08675	COG0745	RESPONSE REGULATOR receiver
DKK66_RS08680	COG5002	protein histidine kinase activity
DKK66_RS08690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DKK66_RS08695	COG3945	hemerythrin HHE cation binding domain
DKK66_RS08705	COG3158	transport of potassium into the cell
DKK66_RS08710	COG0442	prolyl-tRNA aminoacylation
DKK66_RS08715	COG0741	lytic transglycosylase activity
DKK66_RS08720	COG1914	H( )-stimulated, divalent metal cation uptake system
DKK66_RS08725	COG1846	Transcriptional regulator
DKK66_RS08750	COG0028	Belongs to the TPP enzyme family
DKK66_RS08755	COG0440	acetolactate synthase activity
DKK66_RS08760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DKK66_RS08765	COG1183	phosphatidylcholine synthase activity
DKK66_RS08770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DKK66_RS08775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DKK66_RS08790	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DKK66_RS08830	COG1999	signal sequence binding
DKK66_RS08835	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DKK66_RS08840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DKK66_RS08845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DKK66_RS08850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DKK66_RS08855	COG0131	Imidazoleglycerol-phosphate dehydratase
DKK66_RS08860	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DKK66_RS08865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DKK66_RS08870	COG0107	imidazoleglycerol-phosphate synthase activity
DKK66_RS08875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DKK66_RS08880	COG0140	phosphoribosyl-ATP diphosphatase activity
DKK66_RS08890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DKK66_RS08895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DKK66_RS08915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKK66_RS08940	COG1538	Outer membrane efflux protein
DKK66_RS08950	COG0084	hydrolase, TatD family'
DKK66_RS08985	COG2856	Zn peptidase
DKK66_RS09030	COG0582	viral genome integration into host DNA
DKK66_RS09050	COG0792	nuclease activity
DKK66_RS09055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DKK66_RS09060	COG2823	Periplasmic or secreted lipoprotein
DKK66_RS09065	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DKK66_RS09075	COG1720	tRNA m6t6A37 methyltransferase activity
DKK66_RS09085	COG0445	tRNA wobble uridine modification
DKK66_RS09090	COG0357	Ribosomal RNA small subunit methyltransferase G
DKK66_RS09095	COG1192	Involved in chromosome partitioning
DKK66_RS09110	COG0356	it plays a direct role in the translocation of protons across the membrane
DKK66_RS09120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DKK66_RS09125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DKK66_RS09130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DKK66_RS09135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DKK66_RS09140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DKK66_RS09145	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DKK66_RS09150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DKK66_RS09155	COG1349	DNA-binding transcription factor activity
DKK66_RS09160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DKK66_RS09190	COG0477	Major facilitator Superfamily
DKK66_RS09215	COG0583	DNA-binding transcription factor activity
DKK66_RS09220	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DKK66_RS09225	COG5001	Diguanylate cyclase
DKK66_RS09225	COG3447	MASE1 domain protein
DKK66_RS09225	COG5002	protein histidine kinase activity
DKK66_RS09230	COG0408	coproporphyrinogen oxidase activity
DKK66_RS09240	COG2205	protein histidine kinase activity
DKK66_RS09245	COG0745	RESPONSE REGULATOR receiver
DKK66_RS09250	COG1966	Carbon starvation protein
DKK66_RS09255	COG2879	small protein
DKK66_RS09260	COG2855	membrane
DKK66_RS09265	COG0583	DNA-binding transcription factor activity
DKK66_RS09270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DKK66_RS09280	COG1611	Belongs to the LOG family
DKK66_RS09285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DKK66_RS09285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DKK66_RS09345	COG2814	Major facilitator Superfamily
DKK66_RS09350	COG1566	PFAM secretion protein HlyD family protein
DKK66_RS09355	COG1538	Outer membrane efflux protein
DKK66_RS09360	COG1846	Transcriptional regulator
DKK66_RS09365	COG1393	Belongs to the ArsC family
DKK66_RS09400	COG2329	Antibiotic biosynthesis monooxygenase
DKK66_RS09410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DKK66_RS09415	COG1242	4 iron, 4 sulfur cluster binding
DKK66_RS09425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKK66_RS09430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DKK66_RS09430	COG2813	Specifically methylates the guanine in position
DKK66_RS09435	COG2814	Major facilitator Superfamily
DKK66_RS09445	COG2223	nitrite transmembrane transporter activity
DKK66_RS09450	COG2207	Transcriptional regulator
DKK66_RS09465	COG1295	ribonuclease BN
DKK66_RS09465	COG1959	2 iron, 2 sulfur cluster binding
DKK66_RS09480	COG1648	precorrin-2 dehydrogenase activity
DKK66_RS09480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DKK66_RS09490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKK66_RS09495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DKK66_RS09500	COG0859	PFAM glycosyl transferase family 9
DKK66_RS09505	COG0438	transferase activity, transferring glycosyl groups
DKK66_RS09515	COG0438	transferase activity, transferring glycosyl groups
DKK66_RS09520	COG1132	(ABC) transporter
DKK66_RS09530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DKK66_RS09535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DKK66_RS09570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKK66_RS09575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKK66_RS09590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DKK66_RS09595	COG1283	sodium-dependent phosphate transmembrane transporter activity
DKK66_RS09600	COG2755	lipolytic protein G-D-S-L family
DKK66_RS09600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DKK66_RS09615	COG0142	geranyltranstransferase activity
DKK66_RS09620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DKK66_RS09625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DKK66_RS09630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DKK66_RS09645	COG4160	amino acid transport
DKK66_RS09650	COG4598	ABC transporter
DKK66_RS09680	COG1196	nuclear chromosome segregation
DKK66_RS09690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DKK66_RS09705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DKK66_RS09715	COG0840	transmembrane signaling receptor activity
DKK66_RS09755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DKK66_RS09760	COG0339	signal peptide processing
DKK66_RS09765	COG2194	sulfuric ester hydrolase activity
DKK66_RS09770	COG0708	Exodeoxyribonuclease III
DKK66_RS09775	COG2226	methyltransferase
DKK66_RS09790	COG0473	3-isopropylmalate dehydrogenase activity
DKK66_RS09795	COG0438	transferase activity, transferring glycosyl groups
DKK66_RS09805	COG0745	RESPONSE REGULATOR receiver
DKK66_RS09810	COG0642	Histidine kinase
DKK66_RS09860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DKK66_RS09870	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS09875	COG2197	response regulator
DKK66_RS09880	COG0583	DNA-binding transcription factor activity
DKK66_RS09885	COG3154	lipid carrier protein
DKK66_RS09890	COG0826	peptidase U32
DKK66_RS09895	COG0826	peptidase U32
DKK66_RS09905	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DKK66_RS09910	COG1074	ATP-dependent DNA helicase activity
DKK66_RS09925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DKK66_RS09940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKK66_RS09940	COG2205	protein histidine kinase activity
DKK66_RS09945	COG2193	ferroxidase activity
DKK66_RS09960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DKK66_RS10000	COG3245	cytochrome
DKK66_RS10010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DKK66_RS10020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DKK66_RS10030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DKK66_RS10035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DKK66_RS10045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DKK66_RS10050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DKK66_RS10055	COG0193	aminoacyl-tRNA hydrolase activity
DKK66_RS10060	COG0012	GTP binding
DKK66_RS10075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKK66_RS10080	COG0765	amino acid transport
DKK66_RS10085	COG1022	Amp-dependent synthetase and ligase
DKK66_RS10090	COG0626	cystathionine gamma-synthase activity
DKK66_RS10105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKK66_RS10110	COG0067	glutamate synthase
DKK66_RS10110	COG0069	glutamate synthase activity
DKK66_RS10110	COG0070	glutamate synthase
DKK66_RS10120	COG0493	'glutamate synthase
DKK66_RS10130	COG0546	phosphoglycolate phosphatase activity
DKK66_RS10130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DKK66_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS10185	COG1216	Glycosyl transferase, family 2
DKK66_RS10195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DKK66_RS10215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DKK66_RS10225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DKK66_RS10240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DKK66_RS10250	COG0459	protein refolding
DKK66_RS10260	COG0723	plastoquinol--plastocyanin reductase activity
DKK66_RS10265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DKK66_RS10270	COG2857	Cytochrome c1
DKK66_RS10275	COG0625	glutathione transferase activity
DKK66_RS10280	COG2969	positive regulation of protein catabolic process
DKK66_RS10290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DKK66_RS10295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DKK66_RS10300	COG4251	negative regulation of phosphorylation
DKK66_RS10300	COG3706	GGDEF domain
DKK66_RS10300	COG5001	Diguanylate cyclase
DKK66_RS10300	COG2203	Gaf domain
DKK66_RS10305	COG1879	ABC-type sugar transport system periplasmic component
DKK66_RS10310	COG1522	sequence-specific DNA binding
DKK66_RS10320	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DKK66_RS10330	COG0625	glutathione transferase activity
DKK66_RS10345	COG0561	phosphatase activity
DKK66_RS10365	COG0583	DNA-binding transcription factor activity
DKK66_RS10370	COG1301	dicarboxylic acid transport
DKK66_RS10380	COG2095	MarC family integral membrane protein
DKK66_RS10390	COG1194	a g-specific adenine glycosylase
DKK66_RS10395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DKK66_RS10405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DKK66_RS10410	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DKK66_RS10415	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DKK66_RS10420	COG0813	purine-nucleoside phosphorylase activity
DKK66_RS10430	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DKK66_RS10435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DKK66_RS10445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DKK66_RS10450	COG0316	Belongs to the HesB IscA family
DKK66_RS10460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS10465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DKK66_RS10485	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DKK66_RS10490	COG0123	including yeast histone deacetylase and acetoin utilization protein
DKK66_RS10495	COG0714	Associated with various cellular activities
DKK66_RS10510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DKK66_RS10520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DKK66_RS10525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DKK66_RS10530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DKK66_RS10535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DKK66_RS10535	COG0045	succinate-CoA ligase (ADP-forming) activity
DKK66_RS10535	COG1042	CoA-binding domain protein
DKK66_RS10540	COG0228	four-way junction DNA binding
DKK66_RS10545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DKK66_RS10550	COG0336	Belongs to the RNA methyltransferase TrmD family
DKK66_RS10555	COG0335	large ribosomal subunit rRNA binding
DKK66_RS10560	COG4974	Belongs to the 'phage' integrase family
DKK66_RS10565	COG0542	response to heat
DKK66_RS10570	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DKK66_RS10575	COG1278	Cold shock
DKK66_RS10580	COG0477	Major facilitator Superfamily
DKK66_RS10590	COG0538	isocitrate dehydrogenase activity
DKK66_RS10605	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
DKK66_RS10620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DKK66_RS10630	COG1271	oxidase subunit
DKK66_RS10635	COG1294	oxidase, subunit
DKK66_RS10640	COG0584	glycerophosphoryl diester phosphodiesterase
DKK66_RS10645	COG4095	Psort location CytoplasmicMembrane, score
DKK66_RS10660	COG2814	Major facilitator Superfamily
DKK66_RS10670	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DKK66_RS10685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKK66_RS10690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DKK66_RS10695	COG1959	2 iron, 2 sulfur cluster binding
DKK66_RS10700	COG1017	nitric oxide dioxygenase activity
DKK66_RS10700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKK66_RS10720	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS10775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DKK66_RS10775	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKK66_RS10785	COG0477	Major facilitator Superfamily
DKK66_RS10795	COG2113	Glycine betaine
DKK66_RS10810	COG1902	pentaerythritol trinitrate reductase activity
DKK66_RS10810	COG0446	pyridine nucleotide-disulphide oxidoreductase
DKK66_RS10815	COG2181	nitrate reductase activity
DKK66_RS10815	COG0247	lactate metabolic process
DKK66_RS10820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DKK66_RS10835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKK66_RS10840	COG4175	Glycine betaine
DKK66_RS10900	COG3383	formate dehydrogenase (NAD+) activity
DKK66_RS10935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DKK66_RS10940	COG0251	oxidation-reduction process
DKK66_RS10945	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DKK66_RS10950	COG2610	gluconate transmembrane transporter activity
DKK66_RS10960	COG0572	uridine kinase
DKK66_RS10965	COG0625	glutathione transferase activity
DKK66_RS10975	COG0633	Ferredoxin
DKK66_RS10980	COG0443	Heat shock 70 kDa protein
DKK66_RS10985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DKK66_RS10995	COG0822	iron-sulfur transferase activity
DKK66_RS11000	COG1104	cysteine desulfurase activity
DKK66_RS11015	COG0747	negative chemotaxis
DKK66_RS11020	COG0601	transmembrane transport
DKK66_RS11025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DKK66_RS11030	COG0444	Belongs to the ABC transporter superfamily
DKK66_RS11035	COG4608	Belongs to the ABC transporter superfamily
DKK66_RS11040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DKK66_RS11055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKK66_RS11085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKK66_RS11090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS11095	COG0174	glutamine synthetase
DKK66_RS11100	COG0494	nUDIX hydrolase
DKK66_RS11110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DKK66_RS11115	COG0564	pseudouridine synthase activity
DKK66_RS11120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DKK66_RS11120	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DKK66_RS11125	COG0728	peptidoglycan biosynthetic process
DKK66_RS11130	COG0268	Binds directly to 16S ribosomal RNA
DKK66_RS11145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DKK66_RS11160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DKK66_RS11165	COG0450	alkyl hydroperoxide reductase
DKK66_RS11170	COG3706	GGDEF domain
DKK66_RS11185	COG4181	ATPase activity
DKK66_RS11190	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DKK66_RS11200	COG2807	transmembrane transport
DKK66_RS11205	COG2186	Transcriptional regulator
DKK66_RS11215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DKK66_RS11220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DKK66_RS11225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DKK66_RS11230	COG0470	DNA polymerase III
DKK66_RS11240	COG0084	hydrolase, TatD family'
DKK66_RS11245	COG0321	lipoyl(octanoyl) transferase activity
DKK66_RS11245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DKK66_RS11260	COG0156	8-amino-7-oxononanoate synthase activity
DKK66_RS11295	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKK66_RS11300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DKK66_RS11310	COG1216	Glycosyl transferase, family 2
DKK66_RS11350	COG0300	oxidoreductase activity
DKK66_RS11355	COG1368	sulfuric ester hydrolase activity
DKK66_RS11365	COG3045	CreA protein
DKK66_RS11380	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DKK66_RS11390	COG1538	Outer membrane efflux protein
DKK66_RS11395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKK66_RS11400	COG2274	protein secretion by the type I secretion system
DKK66_RS11405	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
DKK66_RS11425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKK66_RS11445	COG0288	reversible hydration of carbon dioxide
DKK66_RS11450	COG1454	alcohol dehydrogenase
DKK66_RS11450	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS11465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DKK66_RS11475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKK66_RS11480	COG2132	Multicopper oxidase
DKK66_RS11485	COG1937	Protein conserved in bacteria
DKK66_RS11495	COG0360	Binds together with S18 to 16S ribosomal RNA
DKK66_RS11505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DKK66_RS11510	COG0359	binds to the 23S rRNA
DKK66_RS11515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS11535	COG1335	isochorismatase
DKK66_RS11540	COG0277	FAD linked oxidase domain protein
DKK66_RS11540	COG0247	lactate metabolic process
DKK66_RS11545	COG0456	acetyltransferase
DKK66_RS11550	COG0456	acetyltransferase
DKK66_RS11565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DKK66_RS11570	COG1716	ATPase activity
DKK66_RS11570	COG5001	Diguanylate cyclase
DKK66_RS11575	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DKK66_RS11580	COG0038	chloride channel
DKK66_RS11585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DKK66_RS11585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DKK66_RS11595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DKK66_RS11600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DKK66_RS11605	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DKK66_RS11620	COG0697	spore germination
DKK66_RS11625	COG0494	nUDIX hydrolase
DKK66_RS11635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DKK66_RS11640	COG3161	chorismate lyase activity
DKK66_RS11650	COG1346	cytolysis
DKK66_RS11660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DKK66_RS11665	COG0583	DNA-binding transcription factor activity
DKK66_RS11675	COG3852	Histidine kinase
DKK66_RS11690	COG0174	glutamine synthetase
DKK66_RS11700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DKK66_RS11705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DKK66_RS11710	COG2239	Acts as a magnesium transporter
DKK66_RS11720	COG1047	Peptidyl-prolyl cis-trans
DKK66_RS11725	COG2850	peptidyl-arginine hydroxylation
DKK66_RS11735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DKK66_RS11740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DKK66_RS11745	COG0488	(ABC) transporter
DKK66_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS11755	COG0583	DNA-binding transcription factor activity
DKK66_RS11760	COG0175	sulfate reduction
DKK66_RS11780	COG0196	riboflavin kinase activity
DKK66_RS11785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DKK66_RS11790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DKK66_RS11795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DKK66_RS11805	COG3960	tartronate-semialdehyde synthase activity
DKK66_RS11810	COG3622	Belongs to the hyi family
DKK66_RS11815	COG2084	Dehydrogenase
DKK66_RS11835	COG3648	Uricase
DKK66_RS11835	COG3195	allantoin biosynthetic process
DKK66_RS11845	COG4266	Belongs to the allantoicase family
DKK66_RS11850	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DKK66_RS11855	COG2233	PERMEase
DKK66_RS11865	COG0326	Molecular chaperone. Has ATPase activity
DKK66_RS11880	COG0583	DNA-binding transcription factor activity
DKK66_RS11885	COG1742	UPF0060 membrane protein
DKK66_RS11890	COG0625	glutathione transferase activity
DKK66_RS11900	COG1122	ATPase activity
DKK66_RS11915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DKK66_RS11920	COG0583	DNA-binding transcription factor activity
DKK66_RS11925	COG0531	amino acid
DKK66_RS11935	COG2224	Isocitrate lyase
DKK66_RS11940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DKK66_RS11945	COG0443	Heat shock 70 kDa protein
DKK66_RS11950	COG0484	heat shock protein binding
DKK66_RS11970	COG0583	DNA-binding transcription factor activity
DKK66_RS11990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DKK66_RS12000	COG1063	alcohol dehydrogenase
DKK66_RS12010	COG0752	glycyl-tRNA synthetase alpha subunit
DKK66_RS12025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DKK66_RS12050	COG0400	carboxylic ester hydrolase activity
DKK66_RS12055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DKK66_RS12070	COG0560	Phosphoserine phosphatase
DKK66_RS12085	COG3220	belongs to the UPF0276 family
DKK66_RS12100	COG0602	queuosine metabolic process
DKK66_RS12105	COG0720	synthase
DKK66_RS12110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DKK66_RS12115	COG1597	lipid kinase activity
DKK66_RS12125	COG1902	pentaerythritol trinitrate reductase activity
DKK66_RS12130	COG0778	Nitroreductase
DKK66_RS12135	COG1309	transcriptional regulator
DKK66_RS12170	COG1454	alcohol dehydrogenase
DKK66_RS12175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DKK66_RS12185	COG2885	chlorophyll binding
DKK66_RS12200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS12210	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS12215	COG0784	Response regulator, receiver
DKK66_RS12215	COG2205	protein histidine kinase activity
DKK66_RS12215	COG5002	protein histidine kinase activity
DKK66_RS12225	COG0864	Transcriptional regulator
DKK66_RS12230	COG1122	ATPase activity
DKK66_RS12235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DKK66_RS12240	COG0310	cobalt ion transport
DKK66_RS12255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKK66_RS12265	COG0318	PFAM AMP-dependent synthetase and ligase
DKK66_RS12295	COG0726	polysaccharide deacetylase
DKK66_RS12300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKK66_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS12320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DKK66_RS12325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKK66_RS12330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKK66_RS12345	COG4797	methyltransferase
DKK66_RS12345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DKK66_RS12350	COG0778	Nitroreductase
DKK66_RS12360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DKK66_RS12380	COG0004	ammonium transporteR
DKK66_RS12385	COG1252	NADH dehydrogenase
DKK66_RS12390	COG0583	DNA-binding transcription factor activity
DKK66_RS12415	COG1335	isochorismatase
DKK66_RS12430	COG2203	Gaf domain
DKK66_RS12430	COG3706	GGDEF domain
DKK66_RS12430	COG4251	negative regulation of phosphorylation
DKK66_RS12430	COG5001	Diguanylate cyclase
DKK66_RS12450	COG1671	Belongs to the UPF0178 family
DKK66_RS12495	COG0463	Glycosyl transferase, family 2
DKK66_RS12505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKK66_RS12505	COG0519	Catalyzes the synthesis of GMP from XMP
DKK66_RS12515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DKK66_RS12520	COG2867	negative regulation of translational initiation
DKK66_RS12525	COG2914	Belongs to the UPF0125 (RnfH) family
DKK66_RS12535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DKK66_RS12540	COG0148	phosphopyruvate hydratase activity
DKK66_RS12545	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DKK66_RS12550	COG0504	CTP synthase activity
DKK66_RS12555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DKK66_RS12560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DKK66_RS12565	COG0519	Catalyzes the synthesis of GMP from XMP
DKK66_RS12565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DKK66_RS12570	COG1573	uracil-dna glycosylase
DKK66_RS12575	COG0456	acetyltransferase
DKK66_RS12580	COG1214	PFAM Peptidase M22, glycoprotease
DKK66_RS12585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DKK66_RS12590	COG0643	Histidine kinase
DKK66_RS12590	COG0784	Response regulator, receiver
DKK66_RS12590	COG2198	Histidine kinase
DKK66_RS12595	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DKK66_RS12600	COG0745	RESPONSE REGULATOR receiver
DKK66_RS12605	COG0835	chemotaxis
DKK66_RS12605	COG0784	Response regulator, receiver
DKK66_RS12610	COG0784	Response regulator, receiver
DKK66_RS12610	COG0835	chemotaxis
DKK66_RS12615	COG3852	Histidine kinase
DKK66_RS12625	COG0840	transmembrane signaling receptor activity
DKK66_RS12635	COG2198	Histidine kinase
DKK66_RS12635	COG0643	Histidine kinase
DKK66_RS12645	COG0840	transmembrane signaling receptor activity
DKK66_RS12650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DKK66_RS12655	COG2201	protein-glutamate methylesterase activity
DKK66_RS12660	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DKK66_RS12670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKK66_RS12675	COG0531	amino acid
DKK66_RS12680	COG2235	arginine
DKK66_RS12685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DKK66_RS12695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DKK66_RS12700	COG0509	glycine decarboxylation via glycine cleavage system
DKK66_RS12710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DKK66_RS12710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DKK66_RS12720	COG0747	negative chemotaxis
DKK66_RS12745	COG1704	LemA family
DKK66_RS12755	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DKK66_RS12765	COG0424	maF-like protein
DKK66_RS12770	COG1399	metal-binding, possibly nucleic acid-binding protein
DKK66_RS12775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DKK66_RS12780	COG0416	fatty acid biosynthetic process
DKK66_RS12785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DKK66_RS12790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DKK66_RS12795	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS12800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DKK66_RS12805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DKK66_RS12810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DKK66_RS12815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DKK66_RS12820	COG2200	EAL domain
DKK66_RS12820	COG2199	diguanylate cyclase activity
DKK66_RS12835	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS12875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKK66_RS12885	COG3501	Rhs element vgr protein
DKK66_RS12945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS12955	COG0023	Translation Initiation Factor
DKK66_RS12960	COG1472	Belongs to the glycosyl hydrolase 3 family
DKK66_RS12965	COG2211	Major facilitator Superfamily
DKK66_RS12970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKK66_RS12970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DKK66_RS12975	COG1105	Belongs to the carbohydrate kinase PfkB family
DKK66_RS12980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DKK66_RS12980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DKK66_RS12985	COG1609	Transcriptional regulator
DKK66_RS12990	COG0583	DNA-binding transcription factor activity
DKK66_RS12995	COG0477	Major facilitator Superfamily
DKK66_RS13000	COG3038	cytochrome b561
DKK66_RS13010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DKK66_RS13015	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DKK66_RS13025	COG0776	regulation of translation
DKK66_RS13035	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DKK66_RS13040	COG0284	orotidine-5'-phosphate decarboxylase activity
DKK66_RS13045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DKK66_RS13045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DKK66_RS13050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DKK66_RS13065	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS13070	COG4689	acetoacetate decarboxylase
DKK66_RS13075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DKK66_RS13085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DKK66_RS13100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKK66_RS13115	COG0395	ABC-type sugar transport system, permease component
DKK66_RS13120	COG1175	transmembrane transport
DKK66_RS13130	COG3842	ATPase activity
DKK66_RS13135	COG4948	Mandelate Racemase Muconate Lactonizing
DKK66_RS13140	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS13155	COG2814	Major facilitator Superfamily
DKK66_RS13215	COG1648	precorrin-2 dehydrogenase activity
DKK66_RS13215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DKK66_RS13220	COG2010	Cytochrome c
DKK66_RS13225	COG3256	nitric oxide reductase
DKK66_RS13230	COG1845	cytochrome c oxidase, subunit III
DKK66_RS13240	COG0714	Associated with various cellular activities
DKK66_RS13285	COG1522	sequence-specific DNA binding
DKK66_RS13295	COG0535	radical SAM domain protein
DKK66_RS13305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKK66_RS13310	COG4774	siderophore transport
DKK66_RS13315	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DKK66_RS13340	COG1120	ATPase activity
DKK66_RS13350	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DKK66_RS13355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DKK66_RS13360	COG3706	GGDEF domain
DKK66_RS13365	COG2197	response regulator
DKK66_RS13370	COG3850	Histidine kinase
DKK66_RS13380	COG2223	nitrite transmembrane transporter activity
DKK66_RS13395	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DKK66_RS13400	COG1140	nitrate reductase beta subunit
DKK66_RS13405	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DKK66_RS13410	COG2181	nitrate reductase activity
DKK66_RS13415	COG3706	GGDEF domain
DKK66_RS13420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DKK66_RS13440	COG2354	Protein conserved in bacteria
DKK66_RS13450	COG3186	Phenylalanine-4-hydroxylase
DKK66_RS13465	COG2205	protein histidine kinase activity
DKK66_RS13465	COG5002	protein histidine kinase activity
DKK66_RS13465	COG0784	Response regulator, receiver
DKK66_RS13470	COG0745	RESPONSE REGULATOR receiver
DKK66_RS13475	COG0784	Response regulator, receiver
DKK66_RS13475	COG2205	protein histidine kinase activity
DKK66_RS13485	COG5001	Diguanylate cyclase
DKK66_RS13530	COG3842	ATPase activity
DKK66_RS13535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DKK66_RS13550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS13555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DKK66_RS13565	COG4566	intracellular signal transduction
DKK66_RS13580	COG1741	Belongs to the pirin family
DKK66_RS13590	COG0583	DNA-binding transcription factor activity
DKK66_RS13595	COG1802	Transcriptional regulator
DKK66_RS13620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DKK66_RS13625	COG0788	formyltetrahydrofolate deformylase activity
DKK66_RS13645	COG1968	undecaprenyl-diphosphatase activity
DKK66_RS13675	COG2308	Evidence 4 Homologs of previously reported genes of
DKK66_RS13715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DKK66_RS13720	COG2137	regulation of response to DNA damage stimulus
DKK66_RS13725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DKK66_RS13730	COG1420	regulation of RNA biosynthetic process
DKK66_RS13735	COG2951	lytic endotransglycosylase activity
DKK66_RS13740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DKK66_RS13745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DKK66_RS13755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DKK66_RS13760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKK66_RS13770	COG2095	MarC family integral membrane protein
DKK66_RS13775	COG2217	Heavy metal translocating P-type atpase
DKK66_RS13800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKK66_RS13805	COG1393	Belongs to the ArsC family
DKK66_RS13815	COG0318	PFAM AMP-dependent synthetase and ligase
DKK66_RS13820	COG0779	Required for maturation of 30S ribosomal subunits
DKK66_RS13825	COG2251	uridine kinase activity
DKK66_RS13825	COG0195	Participates in both transcription termination and antitermination
DKK66_RS13830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DKK66_RS13835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DKK66_RS13840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DKK66_RS13845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DKK66_RS13850	COG1185	polyribonucleotide nucleotidyltransferase activity
DKK66_RS13855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DKK66_RS13870	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS13875	COG3724	N-succinylarginine dihydrolase activity
DKK66_RS13880	COG0559	Belongs to the binding-protein-dependent transport system permease family
DKK66_RS13905	COG1546	Belongs to the CinA family
DKK66_RS13905	COG1058	Belongs to the CinA family
DKK66_RS13920	COG1024	Enoyl-CoA hydratase
DKK66_RS13925	COG1024	Enoyl-CoA hydratase
DKK66_RS13930	COG1960	acyl-CoA dehydrogenase activity
DKK66_RS13940	COG1250	3-hydroxyacyl-CoA dehydrogenase
DKK66_RS13945	COG0789	Transcriptional regulator
DKK66_RS13950	COG0183	Belongs to the thiolase family
DKK66_RS13955	COG0628	permease
DKK66_RS13980	COG3174	membrane
DKK66_RS13985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DKK66_RS13990	COG0142	geranyltranstransferase activity
DKK66_RS13995	COG1722	exodeoxyribonuclease VII activity
DKK66_RS14000	COG0300	oxidoreductase activity
DKK66_RS14025	COG1943	Transposase
DKK66_RS14035	COG0525	valine-tRNA ligase activity
DKK66_RS14055	COG0583	DNA-binding transcription factor activity
DKK66_RS14075	COG0625	glutathione transferase activity
DKK66_RS14085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKK66_RS14100	COG0756	dUTP diphosphatase activity
DKK66_RS14105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DKK66_RS14110	COG2003	Belongs to the UPF0758 family
DKK66_RS14135	COG0121	glutamine amidotransferase
DKK66_RS14140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKK66_RS14150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DKK66_RS14160	COG1522	sequence-specific DNA binding
DKK66_RS14165	COG2070	2-Nitropropane dioxygenase
DKK66_RS14170	COG1335	isochorismatase
DKK66_RS14185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DKK66_RS14190	COG0833	amino acid
DKK66_RS14210	COG1454	alcohol dehydrogenase
DKK66_RS14240	COG2995	paraquat-inducible protein a
DKK66_RS14245	COG3008	intermembrane lipid transfer
DKK66_RS14255	COG0697	spore germination
DKK66_RS14260	COG1187	pseudouridine synthase activity
DKK66_RS14290	COG0183	Belongs to the thiolase family
DKK66_RS14295	COG3243	poly(R)-hydroxyalkanoic acid synthase
DKK66_RS14300	COG0179	Fumarylacetoacetate (FAA) hydrolase
DKK66_RS14305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DKK66_RS14310	COG2814	Major facilitator Superfamily
DKK66_RS14320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DKK66_RS14330	COG0066	3-isopropylmalate dehydratase activity
DKK66_RS14335	COG2226	methyltransferase
DKK66_RS14340	COG0473	3-isopropylmalate dehydrogenase activity
DKK66_RS14365	COG0101	tRNA pseudouridine synthase activity
DKK66_RS14375	COG0133	tryptophan synthase activity
DKK66_RS14380	COG0159	tryptophan synthase activity
DKK66_RS14385	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DKK66_RS14390	COG0277	FAD linked oxidase domain protein
DKK66_RS14395	COG0488	(ABC) transporter
DKK66_RS14400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DKK66_RS14405	COG1765	OsmC-like protein
DKK66_RS14410	COG1815	bacterial-type flagellum-dependent cell motility
DKK66_RS14415	COG1558	bacterial-type flagellum-dependent cell motility
DKK66_RS14420	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DKK66_RS14425	COG1749	Flagellar hook protein flgE
DKK66_RS14430	COG4787	bacterial-type flagellum-dependent cell motility
DKK66_RS14440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DKK66_RS14445	COG1706	bacterial-type flagellum-dependent cell motility
DKK66_RS14450	COG3951	Flagellar rod assembly protein muramidase FlgJ
DKK66_RS14450	COG1705	Flagellar rod assembly protein muramidase FlgJ
DKK66_RS14465	COG2988	succinylglutamate desuccinylase activity
DKK66_RS14470	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DKK66_RS14480	COG2200	EAL domain
DKK66_RS14485	COG3842	ATPase activity
DKK66_RS14490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS14495	COG1166	arginine decarboxylase activity
DKK66_RS14500	COG0531	amino acid
DKK66_RS14515	COG0482	sulfurtransferase activity
DKK66_RS14550	COG1914	H( )-stimulated, divalent metal cation uptake system
DKK66_RS14555	COG0251	oxidation-reduction process
DKK66_RS14560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DKK66_RS14565	COG2925	Exonuclease
DKK66_RS14570	COG1435	thymidine kinase activity
DKK66_RS14580	COG0586	Pfam SNARE associated Golgi protein
DKK66_RS14585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKK66_RS14590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DKK66_RS14595	COG1862	Preprotein translocase
DKK66_RS14600	COG0343	queuine tRNA-ribosyltransferase activity
DKK66_RS14610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DKK66_RS14615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DKK66_RS14620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DKK66_RS14625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DKK66_RS14630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DKK66_RS14635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DKK66_RS14635	COG0072	phenylalanine-tRNA ligase activity
DKK66_RS14640	COG0776	regulation of translation
DKK66_RS14670	COG2205	protein histidine kinase activity
DKK66_RS14670	COG2198	Histidine kinase
DKK66_RS14670	COG0784	Response regulator, receiver
DKK66_RS14675	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS14705	COG1970	mechanosensitive ion channel activity
DKK66_RS14740	COG2866	Carboxypeptidase
DKK66_RS14770	COG4977	sequence-specific DNA binding
DKK66_RS14770	COG1917	Cupin 2, conserved barrel domain protein
DKK66_RS14775	COG1764	response to oxidative stress
DKK66_RS14785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DKK66_RS14795	COG2318	DinB family
DKK66_RS14815	COG2204	response regulator
DKK66_RS14835	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DKK66_RS14855	COG1773	rubredoxin
DKK66_RS14865	COG1773	rubredoxin
DKK66_RS14870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DKK66_RS14920	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DKK66_RS14925	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DKK66_RS14950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKK66_RS14955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKK66_RS14965	COG2350	Protein conserved in bacteria
DKK66_RS14970	COG2917	probably involved in intracellular septation
DKK66_RS14985	COG1739	Uncharacterized protein family UPF0029
DKK66_RS14995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DKK66_RS15005	COG0516	GMP reductase activity
DKK66_RS15010	COG0840	transmembrane signaling receptor activity
DKK66_RS15020	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DKK66_RS15035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DKK66_RS15050	COG2096	Adenosyltransferase
DKK66_RS15060	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DKK66_RS15065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DKK66_RS15075	COG0492	ferredoxin-NADP+ reductase activity
DKK66_RS15095	COG1309	transcriptional regulator
DKK66_RS15100	COG0859	PFAM glycosyl transferase family 9
DKK66_RS15115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DKK66_RS15125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKK66_RS15130	COG0312	modulator of DNA gyrase
DKK66_RS15140	COG0583	DNA-binding transcription factor activity
DKK66_RS15150	COG0745	RESPONSE REGULATOR receiver
DKK66_RS15180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKK66_RS15215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DKK66_RS15240	COG1278	Cold shock
DKK66_RS15255	COG0412	Dienelactone hydrolase
DKK66_RS15270	COG3123	guanosine phosphorylase activity
DKK66_RS15275	COG2771	luxR family
DKK66_RS15275	COG2200	EAL domain
DKK66_RS15280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DKK66_RS15295	COG1289	transmembrane transporter activity
DKK66_RS15315	COG3706	GGDEF domain
DKK66_RS15355	COG0583	DNA-binding transcription factor activity
DKK66_RS15360	COG0778	Nitroreductase
DKK66_RS15365	COG1797	cobyrinic acid a,c-diamide synthase activity
DKK66_RS15390	COG2875	Belongs to the precorrin methyltransferase family
DKK66_RS15400	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DKK66_RS15430	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DKK66_RS15440	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DKK66_RS15445	COG1492	cobalamin metabolic process
DKK66_RS15450	COG3437	response regulator, receiver
DKK66_RS15450	COG3850	Histidine kinase
DKK66_RS15450	COG4999	Histidine kinase
DKK66_RS15450	COG2205	protein histidine kinase activity
DKK66_RS15460	COG2072	flavoprotein involved in K transport
DKK66_RS15480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKK66_RS15485	COG0436	Aminotransferase
DKK66_RS15490	COG0583	DNA-binding transcription factor activity
DKK66_RS15500	COG2814	Major facilitator Superfamily
DKK66_RS15540	COG0583	DNA-binding transcription factor activity
DKK66_RS15545	COG2814	Major facilitator Superfamily
DKK66_RS15550	COG1760	l-serine dehydratase
DKK66_RS15565	COG2040	homocysteine
DKK66_RS15570	COG0840	transmembrane signaling receptor activity
DKK66_RS15575	COG4521	taurine ABC transporter
DKK66_RS15580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DKK66_RS15585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKK66_RS15590	COG2175	clavaminate synthase activity
DKK66_RS15595	COG0513	Belongs to the DEAD box helicase family
DKK66_RS15600	COG0840	transmembrane signaling receptor activity
DKK66_RS15605	COG2081	HI0933 family
DKK66_RS15615	COG0583	DNA-binding transcription factor activity
DKK66_RS15625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKK66_RS15640	COG0688	phosphatidylethanolamine metabolic process
DKK66_RS15645	COG3706	GGDEF domain
DKK66_RS15685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DKK66_RS15695	COG0481	GTPase activity
DKK66_RS15700	COG0681	Belongs to the peptidase S26 family
DKK66_RS15710	COG0571	ribonuclease III activity
DKK66_RS15715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DKK66_RS15725	COG1381	Involved in DNA repair and RecF pathway recombination
DKK66_RS15730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DKK66_RS15735	COG1988	membrane-bound metal-dependent
DKK66_RS15740	COG0736	holo-[acyl-carrier-protein] synthase activity
DKK66_RS15745	COG1472	Belongs to the glycosyl hydrolase 3 family
DKK66_RS15760	COG1643	Atp-dependent helicase
DKK66_RS15790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DKK66_RS15835	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DKK66_RS15870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DKK66_RS15885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DKK66_RS15895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DKK66_RS15950	COG1619	proteins homologs of microcin C7 resistance protein MccF
DKK66_RS15960	COG0175	sulfate reduction
DKK66_RS15965	COG2895	sulfate adenylyltransferase (ATP) activity
DKK66_RS15975	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DKK66_RS15980	COG0564	pseudouridine synthase activity
DKK66_RS15985	COG1744	ABC transporter substrate-binding protein PnrA-like
DKK66_RS15990	COG3845	ABC transporter
DKK66_RS15995	COG4603	Belongs to the binding-protein-dependent transport system permease family
DKK66_RS16000	COG1079	Belongs to the binding-protein-dependent transport system permease family
DKK66_RS16050	COG1294	oxidase, subunit
DKK66_RS16070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DKK66_RS16075	COG0583	DNA-binding transcription factor activity
DKK66_RS16080	COG4221	oxidoreductase activity
DKK66_RS16090	COG0667	Aldo Keto reductase
DKK66_RS16105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKK66_RS16115	COG1538	Outer membrane efflux protein
DKK66_RS16130	COG1621	beta-fructofuranosidase activity
DKK66_RS16140	COG1609	Transcriptional regulator
DKK66_RS16145	COG0583	DNA-binding transcription factor activity
DKK66_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS16160	COG0583	DNA-binding transcription factor activity
DKK66_RS16180	COG3243	poly(R)-hydroxyalkanoic acid synthase
DKK66_RS16185	COG2431	L-lysine efflux transmembrane transporter activity
DKK66_RS16195	COG2814	Major facilitator Superfamily
DKK66_RS16200	COG0583	DNA-binding transcription factor activity
DKK66_RS16210	COG0625	glutathione transferase activity
DKK66_RS16215	COG2378	regulation of single-species biofilm formation
DKK66_RS16220	COG0583	DNA-binding transcription factor activity
DKK66_RS16245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKK66_RS16270	COG0497	DNA recombination
DKK66_RS16275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DKK66_RS16285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DKK66_RS16290	COG0123	including yeast histone deacetylase and acetoin utilization protein
DKK66_RS16320	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS16330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DKK66_RS16350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKK66_RS16355	COG0583	DNA-binding transcription factor activity
DKK66_RS16365	COG2119	membrane
DKK66_RS16375	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DKK66_RS16380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DKK66_RS16400	COG2824	Alkylphosphonate utilization operon protein PhnA
DKK66_RS16405	COG0534	Mate efflux family protein
DKK66_RS16435	COG0415	Belongs to the DNA photolyase family
DKK66_RS16440	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
DKK66_RS16455	COG3046	protein related to deoxyribodipyrimidine photolyase
DKK66_RS16460	COG0415	Belongs to the DNA photolyase family
DKK66_RS16475	COG4221	oxidoreductase activity
DKK66_RS16485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DKK66_RS16495	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DKK66_RS16500	COG1309	transcriptional regulator
DKK66_RS16505	COG0765	amino acid transport
DKK66_RS16510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKK66_RS16555	COG0583	DNA-binding transcription factor activity
DKK66_RS16570	COG0583	DNA-binding transcription factor activity
DKK66_RS16575	COG2200	EAL domain
DKK66_RS16575	COG3287	FIST C domain
DKK66_RS16575	COG2199	diguanylate cyclase activity
DKK66_RS16580	COG0009	L-threonylcarbamoyladenylate synthase
DKK66_RS16585	COG3002	Belongs to the UPF0753 family
DKK66_RS16590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DKK66_RS16595	COG0583	DNA-binding transcription factor activity
DKK66_RS16605	COG3284	Transcriptional regulator
DKK66_RS16610	COG0145	ligase activity
DKK66_RS16615	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
DKK66_RS16620	COG4647	ligase activity
DKK66_RS16625	COG3707	response regulator
DKK66_RS16630	COG1116	anion transmembrane transporter activity
DKK66_RS16630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DKK66_RS16635	COG2223	nitrite transmembrane transporter activity
DKK66_RS16640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DKK66_RS16650	COG0243	molybdopterin cofactor binding
DKK66_RS16670	COG0583	DNA-binding transcription factor activity
DKK66_RS16680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DKK66_RS16690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DKK66_RS16790	COG4983	Phage plasmid primase, P4 family domain protein
DKK66_RS16845	COG0582	viral genome integration into host DNA
DKK66_RS16870	COG3550	peptidyl-serine autophosphorylation
DKK66_RS16915	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKK66_RS16930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DKK66_RS16930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DKK66_RS16955	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DKK66_RS16955	COG0047	phosphoribosylformylglycinamidine synthase activity
DKK66_RS16975	COG1741	Belongs to the pirin family
DKK66_RS16985	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS16990	COG1335	isochorismatase
DKK66_RS16995	COG1335	isochorismatase
DKK66_RS17020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DKK66_RS17030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DKK66_RS17070	COG0346	lactoylglutathione lyase activity
DKK66_RS17085	COG2217	Heavy metal translocating P-type atpase
DKK66_RS17100	COG1217	gtp-binding protein TYPA
DKK66_RS17105	COG0747	negative chemotaxis
DKK66_RS17115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DKK66_RS17125	COG1309	transcriptional regulator
DKK66_RS17135	COG0667	Aldo Keto reductase
DKK66_RS17150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DKK66_RS17160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DKK66_RS17170	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DKK66_RS17175	COG1674	ftsk spoiiie
DKK66_RS17180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DKK66_RS17195	COG1024	Enoyl-CoA hydratase
DKK66_RS17210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DKK66_RS17225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DKK66_RS17245	COG4122	O-methyltransferase activity
DKK66_RS17255	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DKK66_RS17300	COG1215	transferase activity, transferring glycosyl groups
DKK66_RS17305	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DKK66_RS17310	COG0840	transmembrane signaling receptor activity
DKK66_RS17315	COG0436	Aminotransferase
DKK66_RS17320	COG1522	sequence-specific DNA binding
DKK66_RS17330	COG2390	Transcriptional regulator
DKK66_RS17345	COG1175	transmembrane transport
DKK66_RS17360	COG3842	ATPase activity
DKK66_RS17365	COG0246	Mannitol dehydrogenase
DKK66_RS17370	COG1070	Carbohydrate kinase
DKK66_RS17375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DKK66_RS17385	COG0725	ABC transporter, periplasmic molybdate-binding protein
DKK66_RS17390	COG4149	molybdate abc transporter
DKK66_RS17395	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DKK66_RS17410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DKK66_RS17415	COG0513	Belongs to the DEAD box helicase family
DKK66_RS17425	COG3437	response regulator, receiver
DKK66_RS17430	COG0840	transmembrane signaling receptor activity
DKK66_RS17440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKK66_RS17475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DKK66_RS17495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DKK66_RS17500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DKK66_RS17505	COG0174	glutamine synthetase
DKK66_RS17520	COG1538	Outer membrane efflux protein
DKK66_RS17525	COG1566	PFAM secretion protein HlyD family protein
DKK66_RS17530	COG2814	Major facilitator Superfamily
DKK66_RS17535	COG1538	Outer membrane efflux protein
DKK66_RS17540	COG1136	(ABC) transporter
DKK66_RS17540	COG0577	efflux transmembrane transporter activity
DKK66_RS17545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKK66_RS17555	COG2197	response regulator
DKK66_RS17560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DKK66_RS17585	COG0419	ATPase involved in DNA repair
DKK66_RS17590	COG0420	3'-5' exonuclease activity
DKK66_RS17600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DKK66_RS17610	COG1278	Cold shock
DKK66_RS17635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DKK66_RS17640	COG0321	lipoyl(octanoyl) transferase activity
DKK66_RS17645	COG2921	Belongs to the UPF0250 family
DKK66_RS17650	COG1686	Belongs to the peptidase S11 family
DKK66_RS17655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DKK66_RS17700	COG3052	prosthetic group binding
DKK66_RS17720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DKK66_RS17735	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS17740	COG1802	Transcriptional regulator
DKK66_RS17750	COG0679	Auxin Efflux Carrier
DKK66_RS17760	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DKK66_RS17770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DKK66_RS17790	COG0577	efflux transmembrane transporter activity
DKK66_RS17790	COG1136	(ABC) transporter
DKK66_RS17795	COG0604	alcohol dehydrogenase
DKK66_RS17795	COG3321	synthase
DKK66_RS17795	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS17805	COG0004	ammonium transporteR
DKK66_RS17835	COG4191	Histidine kinase
DKK66_RS17935	COG2205	protein histidine kinase activity
DKK66_RS17935	COG2198	Histidine kinase
DKK66_RS17935	COG0784	Response regulator, receiver
DKK66_RS17945	COG2831	hemolysin activation secretion protein
DKK66_RS17950	COG2197	response regulator
DKK66_RS17960	COG3842	ATPase activity
DKK66_RS17970	COG1176	ABC-type spermidine putrescine transport system, permease component I
DKK66_RS17975	COG1177	transmembrane transport
DKK66_RS17985	COG3706	GGDEF domain
DKK66_RS18000	COG1763	Mo-molybdopterin cofactor biosynthetic process
DKK66_RS18020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DKK66_RS18025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKK66_RS18030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKK66_RS18035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DKK66_RS18040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DKK66_RS18060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DKK66_RS18070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DKK66_RS18075	COG0233	cytoplasmic translational termination
DKK66_RS18080	COG0528	UMP kinase activity
DKK66_RS18085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DKK66_RS18090	COG0052	Belongs to the universal ribosomal protein uS2 family
DKK66_RS18105	COG0477	Major facilitator Superfamily
DKK66_RS18115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DKK66_RS18120	COG2816	NAD+ diphosphatase activity
DKK66_RS18130	COG0166	Belongs to the GPI family
DKK66_RS18135	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DKK66_RS18140	COG0501	Belongs to the peptidase M48B family
DKK66_RS18145	COG2154	pterin-4-alpha-carbinolamine dehydratase
DKK66_RS18155	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS18160	COG1956	GAF domain-containing protein
DKK66_RS18170	COG0745	RESPONSE REGULATOR receiver
DKK66_RS18180	COG4974	Belongs to the 'phage' integrase family
DKK66_RS18185	COG0443	Heat shock 70 kDa protein
DKK66_RS18195	COG2321	neutral zinc metallopeptidase
DKK66_RS18200	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DKK66_RS18210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DKK66_RS18215	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DKK66_RS18225	COG0307	riboflavin synthase, alpha
DKK66_RS18235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DKK66_RS18250	COG0842	Transport permease protein
DKK66_RS18255	COG0842	Transport permease protein
DKK66_RS18255	COG1129	ABC transporter
DKK66_RS18260	COG1131	(ABC) transporter
DKK66_RS18265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DKK66_RS18295	COG3447	MASE1 domain protein
DKK66_RS18295	COG5001	Diguanylate cyclase
DKK66_RS18295	COG5002	protein histidine kinase activity
DKK66_RS18310	COG0583	DNA-binding transcription factor activity
DKK66_RS18320	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DKK66_RS18340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DKK66_RS18345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DKK66_RS18350	COG1045	serine acetyltransferase
DKK66_RS18365	COG2011	ABC-type metal ion transport system permease component
DKK66_RS18370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DKK66_RS18380	COG1116	anion transmembrane transporter activity
DKK66_RS18385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DKK66_RS18390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKK66_RS18395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DKK66_RS18400	COG0431	NADPH-dependent FMN reductase
DKK66_RS18415	COG4191	Histidine kinase
DKK66_RS18430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DKK66_RS18435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DKK66_RS18450	COG2822	iron ion transport
DKK66_RS18455	COG0672	)-iron permease
DKK66_RS18470	COG2203	Gaf domain
DKK66_RS18470	COG2199	diguanylate cyclase activity
DKK66_RS18475	COG2372	response to copper ion
DKK66_RS18480	COG1276	copper resistance
DKK66_RS18495	COG2249	NAD(P)H dehydrogenase (quinone) activity
DKK66_RS18505	COG1979	alcohol dehydrogenase
DKK66_RS18515	COG2207	Transcriptional regulator
DKK66_RS18520	COG0348	domain, Protein
DKK66_RS18540	COG0450	alkyl hydroperoxide reductase
DKK66_RS18545	COG2175	clavaminate synthase activity
DKK66_RS18550	COG0679	Auxin Efflux Carrier
DKK66_RS18560	COG0477	Major facilitator Superfamily
DKK66_RS18575	COG2814	Major facilitator Superfamily
DKK66_RS18590	COG1053	succinate dehydrogenase
DKK66_RS18595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DKK66_RS18600	COG1053	succinate dehydrogenase
DKK66_RS18610	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DKK66_RS18610	COG1082	Xylose isomerase domain protein TIM barrel
DKK66_RS18615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DKK66_RS18625	COG1082	Xylose isomerase domain protein TIM barrel
DKK66_RS18630	COG0583	DNA-binding transcription factor activity
DKK66_RS18645	COG0667	Aldo Keto reductase
DKK66_RS18675	COG2159	amidohydrolase
DKK66_RS18680	COG2828	Protein conserved in bacteria
DKK66_RS18690	COG0840	transmembrane signaling receptor activity
DKK66_RS18690	COG3290	protein histidine kinase activity
DKK66_RS18695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DKK66_RS18740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DKK66_RS18755	COG1473	amidohydrolase
DKK66_RS18760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKK66_RS18765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DKK66_RS18795	COG2205	protein histidine kinase activity
DKK66_RS18795	COG0784	Response regulator, receiver
DKK66_RS18795	COG2198	Histidine kinase
DKK66_RS18800	COG5001	Diguanylate cyclase
DKK66_RS18800	COG3300	MHYT domain
DKK66_RS18810	COG0280	phosphate acetyltransferase
DKK66_RS18810	COG0281	malic enzyme
DKK66_RS18815	COG0840	transmembrane signaling receptor activity
DKK66_RS18825	COG0583	DNA-binding transcription factor activity
DKK66_RS18890	COG0488	(ABC) transporter
DKK66_RS18935	COG1858	cytochrome C peroxidase
DKK66_RS18955	COG1595	DNA-templated transcription, initiation
DKK66_RS18960	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DKK66_RS18970	COG1294	oxidase, subunit
DKK66_RS18985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DKK66_RS18990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DKK66_RS18995	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DKK66_RS19005	COG2188	Transcriptional regulator
DKK66_RS19015	COG0765	amino acid transport
DKK66_RS19020	COG0765	amino acid transport
DKK66_RS19025	COG1126	abc transporter atp-binding protein
DKK66_RS19030	COG4266	Belongs to the allantoicase family
DKK66_RS19035	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DKK66_RS19045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DKK66_RS19050	COG0798	PFAM Bile acid sodium symporter
DKK66_RS19065	COG1917	Cupin 2, conserved barrel domain protein
DKK66_RS19065	COG2169	Transcriptional regulator
DKK66_RS19100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DKK66_RS19140	COG0803	Belongs to the bacterial solute-binding protein 9 family
DKK66_RS19150	COG0523	cobalamin synthesis protein
DKK66_RS19175	COG1960	acyl-CoA dehydrogenase activity
DKK66_RS19205	COG0270	DNA (cytosine-5-)-methyltransferase activity
DKK66_RS19240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DKK66_RS19240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DKK66_RS19250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DKK66_RS19260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DKK66_RS19265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DKK66_RS19270	COG3023	N-Acetylmuramoyl-L-alanine amidase
DKK66_RS19275	COG1024	Enoyl-CoA hydratase
DKK66_RS19285	COG0803	Belongs to the bacterial solute-binding protein 9 family
DKK66_RS19290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DKK66_RS19295	COG1121	(ABC) transporter
DKK66_RS19300	COG0523	cobalamin synthesis protein
DKK66_RS19305	COG0735	belongs to the Fur family
DKK66_RS19325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DKK66_RS19335	COG3622	Belongs to the hyi family
DKK66_RS19340	COG0513	Belongs to the DEAD box helicase family
DKK66_RS19345	COG0006	proline dipeptidase activity
DKK66_RS19350	COG0018	arginyl-trna synthetase
DKK66_RS19360	COG1177	transmembrane transport
DKK66_RS19365	COG1176	ABC-type spermidine putrescine transport system, permease component I
DKK66_RS19375	COG0826	peptidase U32
DKK66_RS19390	COG2833	Protein of unknown function (DUF455)
DKK66_RS19395	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DKK66_RS19400	COG2818	Glycosylase
DKK66_RS19410	COG0733	neurotransmitter:sodium symporter activity
DKK66_RS19415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DKK66_RS19445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DKK66_RS19450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DKK66_RS19455	COG2195	Cleaves the N-terminal amino acid of tripeptides
DKK66_RS19465	COG5001	Diguanylate cyclase
DKK66_RS19465	COG5002	protein histidine kinase activity
DKK66_RS19470	COG5265	(ABC) transporter
DKK66_RS19475	COG2967	ApaG domain
DKK66_RS19480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DKK66_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
DKK66_RS19490	COG0546	phosphoglycolate phosphatase activity
DKK66_RS19510	COG0741	lytic transglycosylase activity
DKK66_RS19510	COG1196	nuclear chromosome segregation
DKK66_RS19510	COG0739	heme binding
DKK66_RS19520	COG0617	tRNA 3'-terminal CCA addition
DKK66_RS19535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DKK66_RS19550	COG1360	Flagellar Motor Protein
DKK66_RS19565	COG0174	glutamine synthetase
DKK66_RS19570	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DKK66_RS19575	COG1396	sequence-specific DNA binding
DKK66_RS19575	COG1917	Cupin 2, conserved barrel domain protein
DKK66_RS19580	COG1012	belongs to the aldehyde dehydrogenase family
DKK66_RS19585	COG0840	transmembrane signaling receptor activity
DKK66_RS19590	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DKK66_RS19595	COG1666	GTP binding
DKK66_RS19600	COG1280	lysine exporter protein (LysE YggA)
DKK66_RS19610	COG0137	argininosuccinate synthase activity
DKK66_RS19615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DKK66_RS19625	COG1199	ATP-dependent helicase activity
DKK66_RS19645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DKK66_RS19650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DKK66_RS19660	COG3411	Ferredoxin
DKK66_RS19670	COG2081	HI0933 family
DKK66_RS19675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DKK66_RS19680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DKK66_RS19700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DKK66_RS19705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DKK66_RS19710	COG0740	serine-type endopeptidase activity
DKK66_RS19715	COG0544	peptidyl-prolyl cis-trans isomerase activity
DKK66_RS19770	COG3831	ATPase activity
DKK66_RS19775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DKK66_RS19990	COG0305	Participates in initiation and elongation during chromosome replication